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Gavin Williams - Publications

Affiliations: 
2009- Chemistry North Carolina State University, Raleigh, NC 
Area:
Natural products, drug discovery, chemical biology
Website:
https://williamslab.wordpress.ncsu.edu/?page_id=13
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Calzini MA, Malico AA, Mitchler MM, Williams GJ. Protein engineering for natural product biosynthesis and synthetic biology applications. Protein Engineering, Design & Selection : Peds. 34. PMID 34137436 DOI: 10.1093/protein/gzab015  0.326
2021 Kalkreuter E, Bingham KS, Keeler AM, Lowell AN, Schmidt JJ, Sherman DH, Williams GJ. Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase. Nature Communications. 12: 2193. PMID 33850151 DOI: 10.1038/s41467-021-22497-2  0.306
2021 Mitchler MM, Garcia JM, Montero NE, Williams GJ. Transcription factor-based biosensors: a molecular-guided approach for natural product engineering. Current Opinion in Biotechnology. 69: 172-181. PMID 33493842 DOI: 10.1016/j.copbio.2021.01.008  0.329
2020 Malico AA, Calzini MA, Gayen AK, Williams GJ. Synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis of isoprenoids. Journal of Industrial Microbiology & Biotechnology. PMID 32880770 DOI: 10.1007/s10295-020-02306-3  0.337
2020 Zin PPK, Williams G, Fourches D. SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides Journal of Cheminformatics. 12. DOI: 10.1186/S13321-020-00427-6  0.321
2018 Zin PPK, Williams G, Fourches D. Cheminformatics-based enumeration and analysis of large libraries of macrolide scaffolds. Journal of Cheminformatics. 10: 53. PMID 30421084 DOI: 10.1186/S13321-018-0307-6  0.365
2017 Kasey C, Zerrad M, Li Y, Cropp TA, Williams GJ. Development of transcription factor-based designer macrolide biosensors for metabolic engineering and synthetic biology. Acs Synthetic Biology. PMID 28950701 DOI: 10.1021/acssynbio.7b00287  0.327
2017 Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ. Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. Acs Chemical Biology. 12: 114-123. PMID 28103677 DOI: 10.1021/Acschembio.6B00732  0.306
2013 Koryakina I, McArthur J, Randall S, Draelos MM, Musiol EM, Muddiman DC, Weber T, Williams GJ. Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases. Acs Chemical Biology. 8: 200-8. PMID 23083014 DOI: 10.1021/Cb3003489  0.317
2011 Parajuli N, Williams GJ. A high-throughput screen for directed evolution of aminocoumarin amide synthetases. Analytical Biochemistry. 419: 61-6. PMID 21867669 DOI: 10.1016/j.ab.2011.07.037  0.348
2011 Koryakina I, Neville J, Nonaka K, Van Lanen SG, Williams GJ. A high-throughput screen for directed evolution of the natural product sulfotransferase LipB. Journal of Biomolecular Screening. 16: 845-51. PMID 21753186 DOI: 10.1177/1087057111413273  0.316
2011 Williams GJ, Yang J, Zhang C, Thorson JS. Recombinant E. coli prototype strains for in vivo glycorandomization. Acs Chemical Biology. 6: 95-100. PMID 20886903 DOI: 10.1021/Cb100267K  0.615
2009 Williams GJ, Thorson JS. Natural product glycosyltransferases: properties and applications. Advances in Enzymology and Related Areas of Molecular Biology. 76: 55-119. PMID 18990828 DOI: 10.1002/9780470392881.Ch2  0.496
2008 Gantt RW, Goff RD, Williams GJ, Thorson JS. Probing the aglycon promiscuity of an engineered glycosyltransferase. Angewandte Chemie (International Ed. in English). 47: 8889-92. PMID 18924204 DOI: 10.1002/Anie.200803508  0.708
2008 Williams GJ, Gantt RW, Thorson JS. The impact of enzyme engineering upon natural product glycodiversification. Current Opinion in Chemical Biology. 12: 556-64. PMID 18678278 DOI: 10.1016/J.Cbpa.2008.07.013  0.579
2008 Williams GJ, Goff RD, Zhang C, Thorson JS. Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization. Chemistry & Biology. 15: 393-401. PMID 18420146 DOI: 10.1016/J.Chembiol.2008.02.017  0.687
2008 Williams GJ, Thorson JS. A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution. Nature Protocols. 3: 357-62. PMID 18323806 DOI: 10.1038/Nprot.2007.538  0.528
2007 Williams GJ, Zhang C, Thorson JS. Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution. Nature Chemical Biology. 3: 657-62. PMID 17828251 DOI: 10.1038/Nchembio.2007.28  0.656
2007 Nelson A, Williams G, Woodhall T, Farnsworth L, Berry A. Stereochemically Complementary Biocatalysts Created by Directed Evolution Synfacts. 2007: 0208-0208. DOI: 10.1055/S-2006-955791  0.563
2006 Williams GJ, Woodhall T, Farnsworth LM, Nelson A, Berry A. Creation of a pair of stereochemically complementary biocatalysts. Journal of the American Chemical Society. 128: 16238-47. PMID 17165777 DOI: 10.1021/ja065233q  0.605
2005 Williams GJ, Woodhall T, Nelson A, Berry A. Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis of sialic acid mimetics. Protein Engineering, Design & Selection : Peds. 18: 239-46. PMID 15897188 DOI: 10.1093/Protein/Gzi027  0.601
2005 Woodhall T, Williams G, Berry A, Nelson A. Synthesis of screening substrates for the directed evolution of sialic acid aldolase: towards tailored enzymes for the preparation of influenza A sialidase inhibitor analogues. Organic & Biomolecular Chemistry. 3: 1795-800. PMID 15858666 DOI: 10.1039/B501503K  0.576
2005 Woodhall T, Williams G, Berry A, Nelson A. Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics. Angewandte Chemie (International Ed. in English). 44: 2109-12. PMID 15742315 DOI: 10.1002/Anie.200462733  0.605
2003 Williams GJ, Domann S, Nelson A, Berry A. Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution. Proceedings of the National Academy of Sciences of the United States of America. 100: 3143-8. PMID 12626743 DOI: 10.1073/Pnas.0635924100  0.579
2003 Williams GJ, Berry A. Directed evolution: Creating new enzymes The Biochemist. 25: 13-15. DOI: 10.1042/bio02504013  0.575
2000 Williams G, Nelson A, Berry A. Engineering the Mechanisms of C-C Bond Forming Enzymes Biochemical Society Transactions. 28: A70-A70. DOI: 10.1042/Bst028A070  0.551
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