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Ian A. Wilson, D. Phil., D.Sc. - Publications

Affiliations: 
Molecular Biology Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Structural biology, immunology, X-ray crystallography
Website:
http://www.scripps.edu/mb/wilson/

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 He WT, Yuan M, Callaghan S, Musharrafieh R, Song G, Silva M, Beutler N, Lee WH, Yong P, Torres JL, Melo M, Zhou P, Zhao F, Zhu X, Peng L, ... ... Wilson IA, et al. Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. Science Translational Medicine. 14: eabl9605. PMID 35947674 DOI: 10.1126/scitranslmed.abl9605  0.329
2022 van Schooten J, Farokhi E, Schorcht A, van den Kerkhof TLGM, Gao H, van der Woude P, Burger JA, Meesters TGR, Bijl T, Ghalaiyini R, Turner HL, Dorning J, van Schaik BDC, van Kampen AHC, Labranche CC, ... ... Wilson IA, et al. Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein. Nature Communications. 13: 4515. PMID 35922441 DOI: 10.1038/s41467-022-32208-0  0.807
2022 Liu H, Kaku CI, Song G, Yuan M, Andrabi R, Burton DR, Walker LM, Wilson IA. Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including Omicron. Communications Biology. 5: 766. PMID 35906394 DOI: 10.1038/s42003-022-03700-6  0.327
2022 Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, ... ... Wilson IA, et al. Broadly neutralizing antibodies target the coronavirus fusion peptide. Science (New York, N.Y.). eabq3773. PMID 35857439 DOI: 10.1126/science.abq3773  0.301
2022 Yuan M, Zhu X, He WT, Zhou P, Kaku CI, Capozzola T, Zhu CY, Yu X, Liu H, Yu W, Hua Y, Tien H, Peng L, Song G, Cottrell CA, ... ... Wilson IA, et al. A broad and potent neutralization epitope in SARS-related coronaviruses. Proceedings of the National Academy of Sciences of the United States of America. 119: e2205784119. PMID 35767670 DOI: 10.1073/pnas.2205784119  0.311
2022 Xiang Y, Huang W, Liu H, Sang Z, Nambulli S, Tubiana J, Williams KL, Duprex WP, Schneidman-Duhovny D, Wilson IA, Taylor DJ, Shi Y. Superimmunity by pan-sarbecovirus nanobodies. Cell Reports. 111004. PMID 35738279 DOI: 10.1016/j.celrep.2022.111004  0.34
2022 Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, ... ... Wilson IA, et al. Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Proceedings of the National Academy of Sciences of the United States of America. 119: e2120976119. PMID 35549549 DOI: 10.1073/pnas.2120976119  0.336
2022 Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, ... ... Wilson IA, et al. Broadly neutralizing antibodies target the coronavirus fusion peptide. Biorxiv : the Preprint Server For Biology. PMID 35441178 DOI: 10.1101/2022.04.11.487879  0.303
2022 Beutler N, Pholcharee T, Oyen D, Flores-Garcia Y, MacGill RS, Garcia E, Calla J, Parren M, Yang L, Volkmuth W, Locke E, Regules JA, Dutta S, Emerling D, Early AM, ... ... Wilson IA, et al. A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. Plos Pathogens. 18: e1010409. PMID 35344575 DOI: 10.1371/journal.ppat.1010409  0.314
2022 Cao L, Coventry B, Goreshnik I, Huang B, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, ... ... Wilson IA, et al. Design of protein binding proteins from target structure alone. Nature. PMID 35332283 DOI: 10.1038/s41586-022-04654-9  0.513
2022 Yuan M, Zhu X, He WT, Zhou P, Kaku CI, Capozzola T, Zhu CY, Yu X, Liu H, Yu W, Hua Y, Tien H, Peng L, Song G, Cottrell CA, ... ... Wilson IA, et al. A broad and potent neutralization epitope in SARS-related coronaviruses. Biorxiv : the Preprint Server For Biology. PMID 35313576 DOI: 10.1101/2022.03.13.484037  0.318
2021 Omorodion O, Wilson IA. Structural and Biochemical Characterization of Cysteinylation in Broadly Neutralizing Antibodies to HIV-1. Journal of Molecular Biology. 167303. PMID 34666044 DOI: 10.1016/j.jmb.2021.167303  0.308
2021 Kumar S, Lin X, Ngo T, Shapero B, Sou C, Allen JD, Copps J, Zhang L, Ozorowski G, He L, Crispin M, Ward AB, Wilson IA, Zhu J. Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles. Mbio. e0042921. PMID 34156262 DOI: 10.1128/mBio.00429-21  0.535
2021 Yuan M, Huang D, Lee CD, Wu NC, Jackson AM, Zhu X, Liu H, Peng L, van Gils MJ, Sanders RW, Burton DR, Reincke SM, Prüss H, Kreye J, Nemazee D, ... ... Wilson IA, et al. Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. Science (New York, N.Y.). PMID 34016740 DOI: 10.1126/science.abh1139  0.305
2021 He L, Chaudhary A, Lin X, Sou C, Alkutkar T, Kumar S, Ngo T, Kosviner E, Ozorowski G, Stanfield RL, Ward AB, Wilson IA, Zhu J. Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines. Nature Communications. 12: 2633. PMID 33976149 DOI: 10.1038/s41467-021-22867-w  0.52
2021 Zhou X, Ma F, Xie J, Yuan M, Li Y, Shaabani N, Zhao F, Huang D, Wu NC, Lee CD, Liu H, Li J, Chen Z, Hong Y, Liu WH, ... ... Wilson IA, et al. Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. Cell Reports. 109109. PMID 33932326 DOI: 10.1016/j.celrep.2021.109109  0.314
2021 Lee CD, Watanabe Y, Wu NC, Han J, Kumar S, Pholcharee T, Seabright GE, Allen JD, Lin CW, Yang JR, Liu MT, Wu CY, Ward AB, Crispin M, Wilson IA. A cross-neutralizing antibody between HIV-1 and influenza virus. Plos Pathogens. 17: e1009407. PMID 33750987 DOI: 10.1371/journal.ppat.1009407  0.537
2021 Pholcharee T, Oyen D, Flores-Garcia Y, Gonzalez-Paez G, Han Z, Williams KL, Volkmuth W, Emerling D, Locke E, Richter King C, Zavala F, Wilson IA. Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum. Nature Communications. 12: 1063. PMID 33594061 DOI: 10.1038/s41467-021-21221-4  0.308
2020 Liu H, Wu NC, Yuan M, Bangaru S, Torres JL, Caniels TG, van Schooten J, Zhu X, Lee CD, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA. Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity. Immunity. PMID 33242394 DOI: 10.1016/j.immuni.2020.10.023  0.338
2020 Wu NC, Yuan M, Liu H, Lee CD, Zhu X, Bangaru S, Torres JL, Caniels TG, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA. An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain. Cell Reports. 108274. PMID 33027617 DOI: 10.1016/j.celrep.2020.108274  0.303
2020 Kumar S, Ju B, Shapero B, Lin X, Ren L, Zhang L, Li D, Zhou Z, Feng Y, Sou C, Mann CJ, Hao Y, Sarkar A, Hou J, Nunnally C, ... ... Wilson IA, et al. A V1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite. Science Advances. 6. PMID 32938661 DOI: 10.1126/Sciadv.Abb1328  0.814
2020 Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, ... ... Wilson IA, et al. Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathogens. 16: e1008753. PMID 32866207 DOI: 10.1371/Journal.Ppat.1008753  0.405
2020 Liu H, Wu NC, Yuan M, Bangaru S, Torres JL, Caniels TG, van Schooten J, Zhu X, Lee CD, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA. Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity. Biorxiv : the Preprint Server For Biology. PMID 32793906 DOI: 10.1101/2020.08.02.233536  0.338
2020 Thai E, Costa G, Weyrich A, Murugan R, Oyen D, Flores-Garcia Y, Prieto K, Bosch A, Valleriani A, Wu NC, Pholcharee T, Scally SW, Wilson IA, Wardemann H, Julien JP, et al. A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity. The Journal of Experimental Medicine. 217. PMID 32790871 DOI: 10.1084/Jem.20200061  0.387
2020 Tzarum N, Giang E, Kadam RU, Chen F, Nagy K, Augestad EH, Velázquez-Moctezuma R, Keck ZY, Hua Y, Stanfield RL, Dreux M, Prentoe J, Foung SKH, Bukh J, Wilson IA, et al. An alternate conformation of HCV E2 neutralizing face as an additional vaccine target. Science Advances. 6: eabb5642. PMID 32754640 DOI: 10.1126/Sciadv.Abb5642  0.372
2020 Wu NC, Yuan M, Liu H, Lee CD, Zhu X, Bangaru S, Torres JL, Caniels TG, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA. An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain. Biorxiv : the Preprint Server For Biology. PMID 32743580 DOI: 10.1101/2020.07.26.222232  0.303
2020 Yao Y, Kadam RU, Lee CD, Woehl JL, Wu NC, Zhu X, Kitamura S, Wilson IA, Wolan DW. An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690700 DOI: 10.1073/Pnas.2006893117  0.664
2020 Yuan M, Liu H, Wu NC, Lee CD, Zhu X, Zhao F, Huang D, Yu W, Hua Y, Tien H, Rogers TF, Landais E, Sok D, Jardine JG, Burton DR, ... Wilson IA, et al. Structural basis of a shared antibody response to SARS-CoV-2. Science (New York, N.Y.). PMID 32661058 DOI: 10.1126/Science.Abd2321  0.45
2020 Yan NL, Santos-Martins D, Rennella E, Sanchez BB, Chen JS, Kay LE, Wilson IA, Morgan GJ, Forli S, Kelly JW. Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins. Bioorganic & Medicinal Chemistry Letters. 30: 127356. PMID 32631553 DOI: 10.1016/J.Bmcl.2020.127356  0.355
2020 Wu NC, Andrews SF, Raab JE, O'Connell S, Schramm CA, Ding X, Chambers MJ, Leung K, Wang L, Zhang Y, Mascola JR, Douek DC, Ledgerwood JE, McDermott AB, Wilson IA. Convergent Evolution in Breadth of Two V6-1-Encoded Influenza Antibody Clonotypes from a Single Donor. Cell Host & Microbe. PMID 32619441 DOI: 10.1016/J.Chom.2020.06.003  0.372
2020 Yuan M, Liu H, Wu NC, Lee CD, Zhu X, Zhao F, Huang D, Yu W, Hua Y, Tien H, Rogers TF, Landais E, Sok D, Jardine JG, Burton DR, ... Wilson IA, et al. Structural basis of a public antibody response to SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 32577642 DOI: 10.1101/2020.06.08.141267  0.338
2020 Wu NC, Thompson AJ, Lee JM, Su W, Arlian BM, Xie J, Lerner RA, Yen HL, Bloom JD, Wilson IA. Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses. Science (New York, N.Y.). 368: 1335-1340. PMID 32554590 DOI: 10.1126/Science.Aaz5143  0.305
2020 Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, ... ... Wilson IA, et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science (New York, N.Y.). PMID 32540903 DOI: 10.1126/Science.Abc7520  0.381
2020 Stanfield RL, Berndsen ZT, Huang R, Sok D, Warner G, Torres JL, Burton DR, Ward AB, Wilson IA, Smider VV. Structural basis of broad HIV neutralization by a vaccine-induced cow antibody. Science Advances. 6: eaba0468. PMID 32518821 DOI: 10.1126/Sciadv.Aba0468  0.423
2020 Meng B, Lan K, Xie J, Lerner RA, Wilson IA, Yang B. Inhibitory antibodies identify unique sites of therapeutic vulnerability in rhinovirus and other enteroviruses. Proceedings of the National Academy of Sciences of the United States of America. PMID 32467165 DOI: 10.1073/Pnas.1918844117  0.361
2020 Watanabe Y, Berndsen ZT, Raghwani J, Seabright GE, Allen JD, Pybus OG, McLellan JS, Wilson IA, Bowden TA, Ward AB, Crispin M. Vulnerabilities in coronavirus glycan shields despite extensive glycosylation. Nature Communications. 11: 2688. PMID 32461612 DOI: 10.1038/S41467-020-16567-0  0.353
2020 Lv H, Wu NC, Tak-Yin Tsang O, Yuan M, Perera RAPM, Leung WS, So RTY, Chun Chan JM, Yip GK, Hong Chik TS, Wang Y, Chung Choi CY, Lin Y, Ng WW, Zhao J, ... ... Wilson IA, et al. Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections. Cell Reports. 107725. PMID 32426212 DOI: 10.1016/J.Celrep.2020.107725  0.358
2020 Ward AB, Wilson IA. Innovations in structure-based antigen design and immune monitoring for next generation vaccines. Current Opinion in Immunology. 65: 50-56. PMID 32387642 DOI: 10.1016/J.Coi.2020.03.013  0.36
2020 Rantalainen K, Berndsen ZT, Antanasijevic A, Schiffner T, Zhang X, Lee WH, Torres JL, Zhang L, Irimia A, Copps J, Zhou KH, Kwon YD, Law WH, Schramm CA, Verardi R, ... ... Wilson IA, et al. HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies. Cell Reports. 31: 107583. PMID 32348769 DOI: 10.1016/J.Celrep.2020.107583  0.418
2020 Perera RA, Mok CK, Tsang OT, Lv H, Ko RL, Wu NC, Yuan M, Leung WS, Chan JM, Chik TS, Choi CY, Leung K, Chan KH, Chan KC, Li KC, ... ... Wilson IA, et al. Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin. 25. PMID 32347204 DOI: 10.2807/1560-7917.Es.2020.25.16.2000421  0.307
2020 Yuan M, Wu NC, Zhu X, Lee CD, So RTY, Lv H, Mok CKP, Wilson IA. A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV. Science (New York, N.Y.). PMID 32245784 DOI: 10.1126/Science.Abb7269  0.435
2020 Oyen D, Torres JL, Aoto PC, Flores-Garcia Y, Binter S, Pholcharee T, Carroll S, Reponen S, Wash R, Liang Q, Lemiale F, Locke E, Bradley A, King CR, Emerling D, ... ... Wilson IA, et al. Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein. Plos Pathogens. 16: e1008373. PMID 32150583 DOI: 10.1371/Journal.Ppat.1008373  0.413
2020 Wu NC, Otwinowski J, Thompson AJ, Nycholat CM, Nourmohammad A, Wilson IA. Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape. Nature Communications. 11: 1233. PMID 32144244 DOI: 10.1038/S41467-020-15102-5  0.348
2020 Nguyen DN, Redman RL, Horiya S, Bailey JK, Xu B, Stanfield RL, Temme JS, LaBranche CC, Wang S, Rodal AA, Montefiori DC, Wilson IA, Krauss IJ. The impact of sustained immunization regimens on the antibody response to oligomannose glycans. Acs Chemical Biology. PMID 32109354 DOI: 10.1021/Acschembio.0C00053  0.389
2020 Yang YR, McCoy LE, van Gils MJ, Andrabi R, Turner HL, Yuan M, Cottrell CA, Ozorowski G, Voss J, Pauthner M, Polveroni TM, Messmer T, Wilson IA, Sanders RW, Burton DR, et al. Autologous neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits. Journal of Virology. PMID 31941772 DOI: 10.1128/Jvi.01861-19  0.374
2019 Pholcharee T, Oyen D, Torres JL, Flores-Garcia Y, Martin GM, Gonzalez-Paez G, Emerling D, Volkmuth W, Locke E, King CR, Zavala F, Ward AB, Wilson IA. Diverse antibody responses to conserved structural motifs in Plasmodium falciparum circumsporozoite protein. Journal of Molecular Biology. PMID 31883801 DOI: 10.1016/J.Jmb.2019.12.029  0.41
2019 Zost SJ, Lee J, Gumina ME, Parkhouse K, Henry C, Wu NC, Lee CD, Wilson IA, Wilson PC, Bloom JD, Hensley SE. Identification of Antibodies Targeting the H3N2 Hemagglutinin Receptor Binding Site following Vaccination of Humans. Cell Reports. 29: 4460-4470.e8. PMID 31875553 DOI: 10.1016/J.Celrep.2019.11.084  0.394
2019 Wu NC, Wilson IA. Influenza Hemagglutinin Structures and Antibody Recognition. Cold Spring Harbor Perspectives in Medicine. PMID 31871236 DOI: 10.1101/Cshperspect.A038778  0.39
2019 Ringe RP, Cruz Portillo VM, Dosenovic P, Ketas TJ, Ozorowski G, Nogal B, Perez L, LaBranche CC, Lim J, Francomano E, Wilson IA, Sanders RW, Ward AB, Montefiori DC, Nussenzweig MC, et al. Neutralizing antibody induction by HIV-1 Envelope glycoprotein SOSIP trimers on iron oxide nanoparticles may be impaired by mannose binding lectin. Journal of Virology. PMID 31852794 DOI: 10.1128/Jvi.01883-19  0.35
2019 Zhang L, Irimia A, He L, Landais E, Rantalainen K, Leaman DP, Vollbrecht T, Stano A, Sands DI, Kim AS, Poignard P, Burton DR, Murrell B, Ward AB, ... ... Wilson IA, et al. An MPER antibody neutralizes HIV-1 using germline features shared among donors. Nature Communications. 10: 5389. PMID 31772165 DOI: 10.1038/S41467-019-12973-1  0.424
2019 Gilchuk IM, Bangaru S, Gilchuk P, Irving RP, Kose N, Bombardi RG, Thornburg NJ, Creech CB, Edwards KM, Li S, Turner HL, Yu W, Zhu X, Wilson IA, Ward AB, et al. Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice. Cell Host & Microbe. PMID 31757769 DOI: 10.1016/J.Chom.2019.10.003  0.36
2019 Zhu X, Turner HL, Lang S, McBride R, Bangaru S, Gilchuk IM, Yu W, Paulson JC, Crowe JE, Ward AB, Wilson IA. Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies. Cell Host & Microbe. PMID 31757767 DOI: 10.1016/J.Chom.2019.10.002  0.405
2019 Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, ... ... Wilson IA, et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science (New York, N.Y.). PMID 31672916 DOI: 10.1126/Science.Aax4380  0.406
2019 Stadlbauer D, Zhu X, McMahon M, Turner JS, Wohlbold TJ, Schmitz AJ, Strohmeier S, Yu W, Nachbagauer R, Mudd PA, Wilson IA, Ellebedy AH, Krammer F. Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Science (New York, N.Y.). 366: 499-504. PMID 31649200 DOI: 10.1126/Science.Aay0678  0.379
2019 Xu Q, Biancalana M, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA. Structures of single-layer β-sheet proteins evolved from β-hairpin repeats. Protein Science : a Publication of the Protein Society. PMID 31306512 DOI: 10.1002/Pro.3683  0.301
2019 Adhikary R, Zimmermann J, Stanfield RL, Wilson IA, Yu W, Oda M, Romesberg FE. Structure and Dynamics of Stacking Interactions in an Antibody Binding Site. Biochemistry. PMID 31243995 DOI: 10.1021/acs.biochem.9b00119  0.381
2019 Yuan M, Cottrell CA, Ozorowski G, van Gils MJ, Kumar S, Wu NC, Sarkar A, Torres JL, de Val N, Copps J, Moore JP, Sanders RW, Ward AB, Wilson IA. Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies. Cell Host & Microbe. 25: 873-883.e5. PMID 31194940 DOI: 10.1016/J.Chom.2019.04.011  0.816
2019 Sliepen K, Han BW, Bontjer I, Mooij P, Garces F, Behrens AJ, Rantalainen K, Kumar S, Sarkar A, Brouwer PJM, Hua Y, Tolazzi M, Schermer E, Torres JL, Ozorowski G, ... ... Wilson IA, et al. Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence. Nature Communications. 10: 2355. PMID 31142746 DOI: 10.1038/S41467-019-10262-5  0.816
2019 Watanabe Y, Bowden TA, Wilson IA, Crispin M. Exploitation of glycosylation in enveloped virus pathobiology. Biochimica Et Biophysica Acta. General Subjects. PMID 31121217 DOI: 10.1016/J.Bbagen.2019.05.012  0.331
2019 Andrabi R, Pallesen J, Allen JD, Song G, Zhang J, de Val N, Gegg G, Porter K, Su CY, Pauthner M, Newman A, Bouton-Verville H, Garces F, Wilson IA, Crispin M, et al. The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template. Cell Reports. 27: 2426-2441.e6. PMID 31116986 DOI: 10.1016/J.Celrep.2019.04.082  0.365
2019 Bangaru S, Lang S, Schotsaert M, Vanderven HA, Zhu X, Kose N, Bombardi R, Finn JA, Kent SJ, Gilchuk P, Gilchuk I, Turner HL, García-Sastre A, Li S, Ward AB, ... Wilson IA, et al. A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface. Cell. 177: 1136-1152.e18. PMID 31100268 DOI: 10.1016/J.Cell.2019.04.011  0.341
2019 Hong S, Shi Y, Wu NC, Grande G, Douthit L, Wang H, Zhou W, Sharpless KB, Wilson IA, Xie J, Wu P. Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification. Nature Communications. 10: 1799. PMID 30996301 DOI: 10.1038/S41467-019-09608-W  0.3
2019 Xia S, Yan L, Xu W, Agrawal AS, Algaissi A, Tseng CK, Wang Q, Du L, Tan W, Wilson IA, Jiang S, Yang B, Lu L. A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Science Advances. 5: eaav4580. PMID 30989115 DOI: 10.1126/Sciadv.Aav4580  0.349
2019 Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, et al. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30971495 DOI: 10.1073/Pnas.1817567116  0.339
2019 Murin CD, Wilson IA, Ward AB. Antibody responses to viral infections: a structural perspective across three different enveloped viruses. Nature Microbiology. PMID 30886356 DOI: 10.1038/S41564-019-0392-Y  0.385
2019 Chen F, Tzarum N, Wilson IA, Law M. V1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design. Current Opinion in Virology. 34: 149-159. PMID 30884330 DOI: 10.1016/J.Coviro.2019.02.004  0.409
2019 van Dongen MJP, Kadam RU, Juraszek J, Lawson E, Brandenburg B, Schmitz F, Schepens WBG, Stoops B, van Diepen HA, Jongeneelen M, Tang C, Vermond J, van Eijgen-Obregoso Real A, Blokland S, Garg D, ... ... Wilson IA, et al. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science (New York, N.Y.). 363. PMID 30846569 DOI: 10.1126/Science.Aar6221  0.352
2019 Nguyen DN, Xu B, Stanfield RL, Bailey JK, Horiya S, Temme JS, Leon DR, LaBranche CC, Montefiori DC, Costello CE, Wilson IA, Krauss IJ. Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities. Acs Central Science. 5: 237-249. PMID 30834312 DOI: 10.1021/Acscentsci.8B00588  0.431
2019 Kumar S, Sarkar A, Pugach P, Sanders RW, Moore JP, Ward AB, Wilson IA. Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide. Nature Communications. 10: 763. PMID 30770829 DOI: 10.1038/s41467-019-08738-5  0.809
2019 de Taeye SW, Go EP, Sliepen K, Torrents de la Peña A, Badal K, Medina-Ramirez M, Lee WH, Desaire H, Wilson IA, Moore JP, Ward AB, Sanders RW. Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers. The Journal of Biological Chemistry. PMID 30728245 DOI: 10.1074/Jbc.Ra118.005396  0.387
2019 Turner HL, Pallesen J, Lang S, Bangaru S, Urata S, Li S, Cottrell CA, Bowman CA, Crowe JE, Wilson IA, Ward AB. Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains. Plos Biology. 17: e3000139. PMID 30716060 DOI: 10.1371/Journal.Pbio.3000139  0.409
2019 Sevy AM, Wu NC, Gilchuk IM, Parrish EH, Burger S, Yousif D, Nagel MBM, Schey KL, Wilson IA, Crowe JE, Meiler J. Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses. Proceedings of the National Academy of Sciences of the United States of America. PMID 30642961 DOI: 10.1073/pnas.1806004116  0.404
2019 Tzarum N, Giang E, Kong L, He L, Prentoe J, Augestad E, Hua Y, Castillo S, Lauer GM, Bukh J, Zhu J, Wilson IA, Law M. Genetic and structural insights into broad neutralization of hepatitis C virus by human V1-69 antibodies. Science Advances. 5: eaav1882. PMID 30613781 DOI: 10.1126/Sciadv.Aav1882  0.332
2019 Kumar S, Sarkar A, Pugach P, Sanders RW, Moore JP, Ward AB, Wilson IA. Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide. Nature Communications. 10: 763-763. DOI: 10.2210/Pdb6Mco/Pdb  0.814
2018 Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, ... ... Wilson IA, et al. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers. Immunity. PMID 30552025 DOI: 10.1016/J.Immuni.2018.11.011  0.368
2018 Zost SJ, Wu NC, Hensley SE, Wilson IA. Immunodominance and antigenic variation of influenza virus hemagglutinin: implications for design of universal vaccine immunogens. The Journal of Infectious Diseases. PMID 30535315 DOI: 10.1093/Infdis/Jiy696  0.396
2018 Ringe RP, Pugach P, Cottrell CA, LaBranche CC, Seabright GE, Ketas TJ, Ozorowski G, Kumar S, Schorcht A, van Gils MJ, Crispin M, Montefiori DC, Wilson IA, Ward AB, Sanders RW, et al. Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes. Journal of Virology. PMID 30487280 DOI: 10.1128/Jvi.01656-18  0.612
2018 He L, Kumar S, Allen JD, Huang D, Lin X, Mann CJ, Saye-Francisco KL, Copps J, Sarkar A, Blizard GS, Ozorowski G, Sok D, Crispin M, Ward AB, Nemazee D, ... ... Wilson IA, et al. HIV-1 vaccine design through minimizing envelope metastability. Science Advances. 4: eaau6769. PMID 30474059 DOI: 10.1126/Sciadv.Aau6769  0.795
2018 Laursen NS, Friesen RHE, Zhu X, Jongeneelen M, Blokland S, Vermond J, van Eijgen A, Tang C, van Diepen H, Obmolova G, van der Neut Kolfschoten M, Zuijdgeest D, Straetemans R, Hoffman RMB, Nieusma T, ... ... Wilson IA, et al. Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science (New York, N.Y.). 362: 598-602. PMID 30385580 DOI: 10.1126/Science.Aaq0620  0.382
2018 Credille CV, Dick B, Morrison CN, Stokes RW, Adamek R, Wu NC, Wilson IA, Cohen SM. Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. Journal of Medicinal Chemistry. PMID 30351002 DOI: 10.1021/acs.jmedchem.8b01363  0.315
2018 Oyen D, Torres JL, Cottrell CA, Richter King C, Wilson IA, Ward AB. Cryo-EM structure of circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts. Science Advances. 4: eaau8529. PMID 30324137 DOI: 10.1126/sciadv.aau8529  0.303
2018 Zhang H, Zhu X, Pascual G, Wadia JS, Keogh E, Hoozemans JJ, Siregar B, Inganäs H, Stoop EJM, Goudsmit J, Apetri A, Koudstaal W, Wilson IA. Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody. Structure (London, England : 1993). PMID 30318466 DOI: 10.1016/J.Str.2018.08.012  0.352
2018 Wu NC, Yamayoshi S, Ito M, Uraki R, Kawaoka Y, Wilson IA. Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene. Cell Host & Microbe. 24: 569-578.e4. PMID 30308159 DOI: 10.1016/J.Chom.2018.09.010  0.349
2018 Yang K, Stanfield RL, Martinez-Yamout MA, Dyson HJ, Wilson IA, Wright PE. Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 30232260 DOI: 10.1073/pnas.1810397115  0.353
2018 Yan L, Meng B, Xiang J, Wilson IA, Yang B. Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 Å resolution. Acta Crystallographica. Section D, Structural Biology. 74: 841-851. PMID 30198895 DOI: 10.1107/S2059798318008318  0.369
2018 Bianchi M, Turner HL, Nogal B, Cottrell CA, Oyen D, Pauthner M, Bastidas R, Nedellec R, McCoy LE, Wilson IA, Burton DR, Ward AB, Hangartner L. Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization. Immunity. PMID 30097292 DOI: 10.1016/J.Immuni.2018.07.009  0.375
2018 Bangaru S, Zhang H, Gilchuk IM, Voss TG, Irving RP, Gilchuk P, Matta P, Zhu X, Lang S, Nieusma T, Richt JA, Albrecht RA, Vanderven HA, Bombardi R, Kent SJ, ... ... Wilson IA, et al. A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nature Communications. 9: 2669. PMID 29991715 DOI: 10.1038/S41467-018-04704-9  0.4
2018 Havenar-Daughton C, Sarkar A, Kulp DW, Toy L, Hu X, Deresa I, Kalyuzhniy O, Kaushik K, Upadhyay AA, Menis S, Landais E, Cao L, Diedrich JK, Kumar S, Schiffner T, ... ... Wilson IA, et al. The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. Science Translational Medicine. 10. PMID 29973404 DOI: 10.1126/Scitranslmed.Aat0381  0.785
2018 Aleman F, Tzarum N, Kong L, Nagy K, Zhu J, Wilson IA, Law M. Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. Proceedings of the National Academy of Sciences of the United States of America. PMID 29954862 DOI: 10.1073/Pnas.1802378115  0.365
2018 Tzarum N, Wilson IA, Law M. The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein. Frontiers in Immunology. 9: 1315. PMID 29951061 DOI: 10.3389/Fimmu.2018.01315  0.384
2018 Rantalainen K, Berndsen ZT, Murrell S, Cao L, Omorodion O, Torres JL, Wu M, Umotoy J, Copps J, Poignard P, Landais E, Paulson JC, Wilson IA, Ward AB. Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Reports. 23: 3249-3261. PMID 29898396 DOI: 10.1016/J.Celrep.2018.05.046  0.414
2018 Oyen D, Torres JL, Wille-Reece U, Ockenhouse CF, Emerling D, Glanville J, Volkmuth W, Flores-Garcia Y, Zavala F, Ward AB, King CR, Wilson IA. Erratum: Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (E10438–E10445) DOI: 10.1073/pnas.1715812114) Proceedings of the National Academy of Sciences of the United States of America. 115. PMID 29891667 DOI: 10.1073/Pnas.1808460115  0.339
2018 Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, Zhang H, Keogh E, Holland T, Wadia J, Verveen H, Siregar B, Mrosek M, Taggenbrock R, Ameijde J, ... ... Wilson IA, et al. A common antigenic motif recognized by naturally occurring human V5-51/V4-1 anti-tau antibodies with distinct functionalities. Acta Neuropathologica Communications. 6: 43. PMID 29855358 DOI: 10.1186/S40478-018-0543-Z  0.362
2018 Sarkar A, Bale S, Behrens AJ, Kumar S, Sharma SK, de Val N, Pallesen J, Irimia A, Diwanji DC, Stanfield RL, Ward AB, Crispin M, Wyatt RT, Wilson IA. Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. Nature Communications. 9: 1956. PMID 29769533 DOI: 10.1038/S41467-018-04272-Y  0.823
2018 Kadam RU, Wilson IA. A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America. PMID 29610325 DOI: 10.2210/Pdb6Cf5/Pdb  0.392
2018 Gunn RJ, Herrin BR, Acharya S, Cooper MD, Wilson IA. VLR recognition of TLR5 expands the molecular characterization of protein antigen binding by non-Ig-based antibodies. Journal of Molecular Biology. PMID 29596914 DOI: 10.1016/J.Jmb.2018.03.016  0.408
2018 Crispin M, Ward AB, Wilson IA. Structure and Immune Recognition of the HIV Glycan Shield. Annual Review of Biophysics. PMID 29595997 DOI: 10.1146/Annurev-Biophys-060414-034156  0.414
2018 Wu NC, Thompson AJ, Xie J, Lin CW, Nycholat CM, Zhu X, Lerner RA, Paulson JC, Wilson IA. A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nature Communications. 9: 1264. PMID 29593268 DOI: 10.1038/S41467-018-03663-5  0.351
2018 Tan J, Sack BK, Oyen D, Zenklusen I, Piccoli L, Barbieri S, Foglierini M, Fregni CS, Marcandalli J, Jongo S, Abdulla S, Perez L, Corradin G, Varani L, Sallusto F, ... ... Wilson IA, et al. A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein. Nature Medicine. PMID 29554084 DOI: 10.1038/Nm.4513  0.405
2018 Klasse PJ, Ketas TJ, Cottrell CA, Ozorowski G, Debnath G, Camara D, Francomano E, Pugach P, Ringe RP, LaBranche CC, van Gils MJ, Bricault CA, Barouch DH, Crotty S, Silvestri G, ... ... Wilson IA, et al. Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques. Plos Pathogens. 14: e1006913. PMID 29474444 DOI: 10.1371/Journal.Ppat.1006913  0.414
2018 Stanfield RL, Haakenson J, Deiss TC, Criscitiello MF, Wilson IA, Smider VV. The Unusual Genetics and Biochemistry of Bovine Immunoglobulins. Advances in Immunology. 137: 135-164. PMID 29455846 DOI: 10.1016/Bs.Ai.2017.12.004  0.405
2018 Behrens AJ, Kumar A, Medina-Ramirez M, Cupo A, Marshall K, Cruz Portillo VM, Harvey DJ, Ozorowski G, Zitzmann N, Wilson IA, Ward AB, Struwe WB, Moore JP, Sanders RW, Crispin M. Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages. Journal of Proteome Research. PMID 29420040 DOI: 10.1021/Acs.Jproteome.7B00639  0.366
2018 Wu NC, Wilson IA. Structural insights into the design of novel anti-influenza therapies. Nature Structural & Molecular Biology. PMID 29396418 DOI: 10.1038/S41594-018-0025-9  0.375
2018 Oyen D, Torres JL, Cottrell CA, King CR, Wilson IA, Ward AB. Cryo-EM structure ofP. falciparumcircumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts. Science Advances. 4. DOI: 10.2210/Pdb6Mhg/Pdb  0.415
2018 Wu NC, Yamayoshi S, Ito M, Uraki R, Kawaoka Y, Wilson IA. The D3-9 gene segment encodes for recurring and adaptable binding motifs in broadly neutralizing antibodies to influenza virus Cell Host & Microbe. DOI: 10.2210/Pdb6E3H/Pdb  0.344
2018 Wilson IA. Structure-assisted design of universal vaccines and therapeutics against influenza virus Acta Crystallographica Section a Foundations and Advances. 74: a114-a114. DOI: 10.1107/S0108767318098859  0.311
2018 Stanfield RL, Nguyen DN, Krauss IJ, Wilson IA. Synthetic glycopeptide selected by directed evolution in complex with anti-HIV-1 Fab 2G12 Acta Crystallographica Section a Foundations and Advances. 74: a178-a178. DOI: 10.1107/S0108767318098215  0.302
2017 Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society. PMID 29265822 DOI: 10.1021/Jacs.7B08366  0.315
2017 Gopal R, Jackson K, Tzarum N, Kong L, Ettenger A, Guest J, Pfaff JM, Barnes T, Honda A, Giang E, Davidson E, Wilson IA, Doranz BJ, Law M. Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis. Plos Pathogens. 13: e1006735. PMID 29253863 DOI: 10.1371/Journal.Ppat.1006735  0.378
2017 de Taeye SW, Torrents de la Peña A, Vecchione A, Scutigliani E, Sliepen K, Burger JA, van der Woude P, Schorcht A, Schermer EE, van Gils MJ, LaBranche CC, Montefiori DC, Wilson IA, Moore JP, Ward AB, et al. Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers. The Journal of Biological Chemistry. PMID 29222332 DOI: 10.1074/Jbc.Ra117.000709  0.373
2017 Collins BC, Nakahara H, Acharya S, Cooper MD, Herrin BR, Wilson IA. Crystal structure of an anti-idiotype variable lymphocyte receptor. Acta Crystallographica. Section F, Structural Biology Communications. 73: 682-687. PMID 29199989 DOI: 10.1107/S2053230X1701620X  0.414
2017 Landais E, Murrell B, Briney B, Murrell S, Rantalainen K, Berndsen ZT, Ramos A, Wickramasinghe L, Smith ML, Eren K, de Val N, Wu M, Cappelletti A, Umotoy J, Lie Y, ... ... Wilson IA, et al. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity. 47: 990-1003.e9. PMID 29166592 DOI: 10.1016/J.Immuni.2017.11.002  0.385
2017 Dey AK, Cupo A, Ozorowski G, Sharma VK, Behrens AJ, Go EP, Ketas TJ, Yasmeen A, Klasse PJ, Sayeed E, Desaire H, Crispin M, Wilson IA, Sanders RW, Hassell T, et al. cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate. Biotechnology and Bioengineering. PMID 29150937 DOI: 10.1002/Bit.26498  0.377
2017 Pantophlet R, Trattnig N, Murrell S, Lu N, Chau D, Rempel C, Wilson IA, Kosma P. Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity. Nature Communications. 8: 1601. PMID 29150603 DOI: 10.1038/S41467-017-01640-Y  0.425
2017 Oyen D, Torres JL, Wille-Reece U, Ockenhouse CF, Emerling D, Glanville J, Volkmuth W, Flores-Garcia Y, Zavala F, Ward AB, King CR, Wilson IA. Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein. Proceedings of the National Academy of Sciences of the United States of America. PMID 29138320 DOI: 10.1073/Pnas.1715812114  0.422
2017 Wu NC, Zost SJ, Thompson AJ, Oyen D, Nycholat CM, McBride R, Paulson JC, Hensley SE, Wilson IA. A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. Plos Pathogens. 13: e1006682. PMID 29059230 DOI: 10.1371/Journal.Ppat.1006682  0.371
2017 Collins BC, Gunn RJ, McKitrick TR, Cummings RD, Cooper MD, Herrin BR, Wilson IA. Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates. Structure (London, England : 1993). PMID 28988747 DOI: 10.1016/J.Str.2017.09.003  0.374
2017 Voss JE, Andrabi R, McCoy LE, de Val N, Fuller RP, Messmer T, Su CY, Sok D, Khan SN, Garces F, Pritchard LK, Wyatt RT, Ward AB, Crispin M, Wilson IA, et al. Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model. Cell Reports. 21: 222-235. PMID 28978475 DOI: 10.1016/J.Celrep.2017.09.024  0.4
2017 Kadam RU, Juraszek J, Brandenburg B, Buyck C, Schepens WBG, Kesteleyn B, Stoops B, Vreeken R, Vermond J, Goutier W, Tang C, Vogels R, Friesen RHE, Goudsmit J, van Dongen MJP, ... Wilson IA, et al. Potent peptidic fusion inhibitors of influenza virus. Science (New York, N.Y.). PMID 28971971 DOI: 10.1126/Science.Aan0516  0.34
2017 Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, ... ... Wilson IA, et al. Massively parallel de novo protein design for targeted therapeutics. Nature. PMID 28953867 DOI: 10.1038/Nature23912  0.334
2017 Lang S, Xie J, Zhu X, Wu NC, Lerner RA, Wilson IA. Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem. Cell Reports. 20: 2935-2943. PMID 28930686 DOI: 10.1016/J.Celrep.2017.08.084  0.358
2017 Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof TLGM, Freund NT, Dosenovic P, Hua Y, Gitlin AD, ... ... Wilson IA, et al. Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo. The Journal of Experimental Medicine. PMID 28847869 DOI: 10.1084/Jem.20161160  0.471
2017 Torrents de la Peña A, Julien JP, de Taeye SW, Garces F, Guttman M, Ozorowski G, Pritchard LK, Behrens AJ, Go EP, Burger JA, Schermer EE, Sliepen K, Ketas TJ, Pugach P, Yasmeen A, ... ... Wilson IA, et al. Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization. Cell Reports. 20: 1805-1817. PMID 28834745 DOI: 10.1016/J.Celrep.2017.07.077  0.413
2017 Koch K, Kalusche S, Torres JL, Stanfield RL, Danquah W, Khazanehdari K, von Briesen H, Geertsma ER, Wilson IA, Wernery U, Koch-Nolte F, Ward AB, Dietrich U. Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers. Scientific Reports. 7: 8390. PMID 28827559 DOI: 10.1038/S41598-017-08273-7  0.377
2017 Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA. Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host & Microbe. 22: 247-248. PMID 28799910 DOI: 10.1016/J.Chom.2017.07.001  0.312
2017 Sok D, Le KM, Vadnais M, Saye-Francisco K, Jardine JG, Torres J, Berndsen ZT, Kong L, Stanfield R, Ruiz J, Ramos A, Liang CH, Chen PL, Criscitiello MF, Mwangi W, ... Wilson IA, et al. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows. Nature. PMID 28726771 DOI: 10.1038/Nature23301  0.388
2017 Ozorowski G, Pallesen J, de Val N, Lyumkis D, Cottrell CA, Torres JL, Copps J, Stanfield RL, Cupo A, Pugach P, Moore JP, Wilson IA, Ward AB. Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. Nature. PMID 28700571 DOI: 10.1038/Nature23010  0.434
2017 de Vries RP, Tzarum N, Peng W, Thompson AJ, Ambepitiya Wickramasinghe IN, de la Pena ATT, van Breemen MJ, Bouwman KM, Zhu X, McBride R, Yu W, Sanders RW, Verheije MH, Wilson IA, Paulson JC. A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors. Embo Molecular Medicine. PMID 28694323 DOI: 10.15252/Emmm.201707726  0.334
2017 Wright ZVF, Wu NC, Kadam RU, Wilson IA, Wolan DW. Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin. Bioorganic & Medicinal Chemistry Letters. PMID 28689973 DOI: 10.1016/J.Bmcl.2017.06.074  0.67
2017 Wu NC, Wilson IA. A perspective on the structural and functional constraints for immune evasion: Insights from the influenza virus. Journal of Molecular Biology. PMID 28648617 DOI: 10.1016/J.Jmb.2017.06.015  0.374
2017 Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, ... ... Wilson IA, et al. Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches. Immunity. 46: 1073-1088.e6. PMID 28636956 DOI: 10.1016/J.Immuni.2017.05.007  0.344
2017 Park S, Stanfield RL, Martinez-Yamout MA, Dyson HJ, Wilson IA, Wright PE. Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630323 DOI: 10.1073/Pnas.1703105114  0.319
2017 Connelly S, Mortenson DE, Choi S, Wilson IA, Powers ET, Kelly JW, Johnson SM. Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28625364 DOI: 10.1016/J.Bmcl.2017.05.080  0.312
2017 Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA. Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host & Microbe. 21: 742-753.e8. PMID 28618270 DOI: 10.1016/J.Chom.2017.05.011  0.352
2017 Luo X, Fu G, Wang RE, Zhu X, Zambaldo C, Liu R, Liu T, Lyu X, Du J, Xuan W, Yao A, Reed SA, Kang M, Zhang Y, Guo H, ... ... Wilson IA, et al. Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria. Nature Chemical Biology. PMID 28604693 DOI: 10.1038/Nchembio.2405  0.33
2017 Strauch EM, Bernard SM, La D, Bohn AJ, Lee PS, Anderson CE, Nieusma T, Holstein CA, Garcia NK, Hooper KA, Ravichandran R, Nelson JW, Sheffler W, Bloom JD, Lee KK, ... ... Wilson IA, et al. Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site. Nature Biotechnology. PMID 28604661 DOI: 10.1038/Nbt.3907  0.362
2017 Ringe RP, Ozorowski G, Rantalainen K, Struwe WB, Matthews K, Torres JL, Yasmeen A, Cottrell CA, Ketas TJ, LaBranche CC, Montefiori DC, Cupo A, Crispin M, Wilson IA, Ward AB, et al. Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 Env SOSIP trimers. Journal of Virology. PMID 28539451 DOI: 10.1128/Jvi.00677-17  0.426
2017 Guenaga J, Garces F, de Val N, Stanfield RL, Dubrovskaya V, Higgins B, Carrette B, Ward AB, Wilson IA, Wyatt RT. Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein. Immunity. 46: 792-803.e3. PMID 28514686 DOI: 10.1016/J.Immuni.2017.04.014  0.418
2017 Wu NC, Grande G, Turner HL, Ward AB, Xie J, Lerner RA, Wilson IA. In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity. Nature Communications. 8: 15371. PMID 28504265 DOI: 10.1038/Ncomms15371  0.389
2017 Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, ... Wilson IA, et al. A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure. Immunity. 46: 690-702. PMID 28423342 DOI: 10.1016/J.Immuni.2017.03.017  0.441
2017 Tzarum N, de Vries RP, Peng W, Thompson AJ, Bouwman KM, McBride R, Yu W, Zhu X, Verheije MH, Paulson JC, Wilson IA. The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus. Cell Reports. 19: 235-245. PMID 28402848 DOI: 10.1016/J.Celrep.2017.03.054  0.328
2017 Ringe RP, Ozorowski G, Yasmeen A, Cupo A, Cruz Portillo VM, Pugach P, Golabek M, Rantalainen K, Holden LG, Cottrell CA, Wilson IA, Sanders RW, Ward AB, Klasse PJ, Moore JP. Improving the expression and purification of soluble, recombinant native-like HIV-1 envelope glycoprotein trimers by targeted sequence changes. Journal of Virology. PMID 28381572 DOI: 10.1128/Jvi.00264-17  0.427
2017 Pascual G, Wadia JS, Zhu X, Keogh E, Kükrer B, van Ameijde J, Inganäs H, Siregar B, Perdok G, Diefenbach O, Nahar T, Sprengers I, Koldijk MH, der Linden EC, Peferoen LA, ... ... Wilson IA, et al. Immunological memory to hyperphosphorylated tau in asymptomatic individuals. Acta Neuropathologica. PMID 28341999 DOI: 10.1007/S00401-017-1705-Y  0.365
2017 Polonskaya Z, Deng S, Sarkar A, Kain L, Comellas-Aragones M, McKay CS, Kaczanowska K, Holt M, McBride R, Palomo V, Self KM, Taylor S, Irimia A, Mehta SR, Dan JM, ... ... Wilson IA, et al. T cells control the generation of nanomolar-affinity anti-glycan antibodies. The Journal of Clinical Investigation. PMID 28287405 DOI: 10.1172/Jci91192  0.749
2017 Irimia A, Serra AM, Sarkar A, Jacak R, Kalyuzhniy O, Sok D, Saye-Francisco KL, Schiffner T, Tingle R, Kubitz M, Adachi Y, Stanfield RL, Deller MC, Burton DR, Schief WR, ... Wilson IA, et al. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design. Plos Pathogens. 13: e1006212. PMID 28225819 DOI: 10.1371/Journal.Ppat.1006212  0.756
2017 Ward AB, Wilson IA. The HIV-1 envelope glycoprotein structure: nailing down a moving target. Immunological Reviews. 275: 21-32. PMID 28133813 DOI: 10.1111/Imr.12507  0.458
2016 Peng W, de Vries RP, Grant OC, Thompson AJ, McBride R, Tsogtbaatar B, Lee PS, Razi N, Wilson IA, Woods RJ, Paulson JC. Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity. Cell Host & Microbe. PMID 28017661 DOI: 10.1016/J.Chom.2016.11.004  0.308
2016 Kadam RU, Wilson IA. Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol. Proceedings of the National Academy of Sciences of the United States of America. PMID 28003465 DOI: 10.1073/Pnas.1617020114  0.383
2016 van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, ... ... Wilson IA, et al. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability. Nature Microbiology. 2: 16199. PMID 27841852 DOI: 10.1038/Nmicrobiol.2016.199  0.42
2016 Kong L, Lee DE, Kadam RU, Liu T, Giang E, Nieusma T, Garces F, Tzarum N, Woods VL, Ward AB, Li S, Wilson IA, Law M. Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791120 DOI: 10.1073/Pnas.1609780113  0.341
2016 Das N, Dewan V, Grace PM, Gunn RJ, Tamura R, Tzarum N, Watkins LR, Wilson IA, Yin H. HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia. Cell Reports. 17: 1128-1140. PMID 27760316 DOI: 10.1016/J.Celrep.2016.09.076  0.496
2016 Jardine JG, Sok D, Julien JP, Briney B, Sarkar A, Liang CH, Scherer EM, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, ... ... Wilson IA, et al. Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. Plos Pathogens. 12: e1005905. PMID 27627763 DOI: 10.1371/Journal.Ppat.1005905  0.747
2016 Klasse PJ, LaBranche CC, Ketas TJ, Ozorowski G, Cupo A, Pugach P, Ringe RP, Golabek M, van Gils MJ, Guttman M, Lee KK, Wilson IA, Butera ST, Ward AB, Montefiori DC, et al. Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C. Plos Pathogens. 12: e1005864. PMID 27627672 DOI: 10.1371/Journal.Ppat.1005864  0.342
2016 Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, ... ... Wilson IA, et al. HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity. PMID 27617678 DOI: 10.1016/J.Immuni.2016.08.016  0.383
2016 Briney B, Sok D, Jardine JG, Kulp DW, Skog P, Menis S, Jacak R, Kalyuzhniy O, de Val N, Sesterhenn F, Le KM, Ramos A, Jones M, Saye-Francisco KL, Blane TR, ... ... Wilson IA, et al. Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. Cell. 166: 1459-1470.e11. PMID 27610570 DOI: 10.1016/J.Cell.2016.08.005  0.771
2016 Stanfield RL, Wilson IA, Smider VV. Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies. Science Immunology. 1. PMID 27574710 DOI: 10.1126/Sciimmunol.Aaf7962  0.384
2016 Jardine JG, Sok D, Julien JP, Briney B, Sarkar A, Liang CH, Scherer EA, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, ... ... Wilson IA, et al. Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. Plos Pathogens. 12: e1005815. PMID 27560183 DOI: 10.1371/Journal.Ppat.1005815  0.758
2016 McCoy LE, van Gils MJ, Ozorowski G, Messmer T, Briney B, Voss JE, Kulp DW, Macauley MS, Sok D, Pauthner M, Menis S, Cottrell CA, Torres JL, Hsueh J, Schief WR, ... Wilson IA, et al. Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies. Cell Reports. PMID 27545891 DOI: 10.1016/J.Celrep.2016.07.074  0.404
2016 Sok D, Pauthner M, Briney B, Lee JH, Saye-Francisco KL, Hsueh J, Ramos A, Le KM, Jones M, Jardine JG, Bastidas R, Sarkar A, Liang CH, Shivatare SS, Wu CY, ... ... Wilson IA, et al. A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans. Immunity. 45: 31-45. PMID 27438765 DOI: 10.1016/J.Immuni.2016.06.026  0.787
2016 Proudfoot A, Geralt M, Elsliger MA, Wilson IA, Wüthrich K, Serrano P. Dynamic Local Polymorphisms in the Gbx1 Homeodomain Induced by DNA Binding. Structure (London, England : 1993). 24: 1372-9. PMID 27396829 DOI: 10.1016/J.Str.2016.05.013  0.302
2016 He L, de Val N, Morris CD, Vora N, Thinnes TC, Kong L, Azadnia P, Sok D, Zhou B, Burton DR, Wilson IA, Nemazee D, Ward AB, Zhu J. Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles. Nature Communications. 7: 12041. PMID 27349934 DOI: 10.1038/Ncomms12041  0.347
2016 Kong L, He L, de Val N, Vora N, Morris CD, Azadnia P, Sok D, Zhou B, Burton DR, Ward AB, Wilson IA, Zhu J. Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability. Nature Communications. 7: 12040. PMID 27349805 DOI: 10.1038/Ncomms12040  0.373
2016 MacLeod DT, Choi NM, Briney B, Garces F, Ver LS, Landais E, Murrell B, Wrin T, Kilembe W, Liang CH, Ramos A, Bian CB, Wickramasinghe L, Kong L, Eren K, ... ... Wilson IA, et al. Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch. Immunity. 44: 1215-1226. PMID 27192579 DOI: 10.1016/J.Immuni.2016.04.016  0.368
2016 Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/Jacs.6B02960  0.386
2016 Serrano P, Dutta SK, Proudfoot A, Mohanty B, Susac L, Martin B, Geralt M, Jaroszewski L, Godzik A, Elsliger M, Wilson IA, Wüthrich K. NMR in structural genomics to increase structural coverage of the protein universe: Delivered by Prof. Kurt Wüthrich on 7 July 2013 at the 38th FEBS Congress in St. Petersburg, Russia. The Febs Journal. 283: 3870-3881. PMID 27154589 DOI: 10.1111/Febs.13751  0.35
2016 Chen W, Kong L, Connelly S, Dendle JM, Liu Y, Wilson IA, Powers ET, Kelly JW. Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chemical Biology. PMID 27128252 DOI: 10.1021/Acschembio.5B01035  0.4
2016 Kong L, Ju B, Chen Y, He L, Ren L, Liu J, Hong K, Su B, Wang Z, Ozorowski G, Ji X, Hua Y, Chen Y, Deller MC, Hao Y, ... ... Wilson IA, et al. Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor. Immunity. PMID 27067056 DOI: 10.1016/J.Immuni.2016.03.006  0.435
2016 Xu Q, Shoji M, Shibata S, Naito M, Sato K, Elsliger MA, Grant JC, Axelrod HL, Chiu HJ, Farr CL, Jaroszewski L, Knuth MW, Deacon AM, Godzik A, Lesley SA, ... ... Wilson IA, et al. A Distinct Type of Pilus from the Human Microbiome. Cell. PMID 27062925 DOI: 10.1016/J.Cell.2016.03.016  0.373
2016 Stepanyuk GA, Serrano P, Peralta E, Farr CL, Axelrod HL, Geralt M, Das D, Chiu HJ, Jaroszewski L, Deacon AM, Lesley SA, Elsliger MA, Godzik A, Wilson IA, Wüthrich K, et al. UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex. Acta Crystallographica. Section D, Structural Biology. 72: 497-511. PMID 27050129 DOI: 10.1107/S2059798316001248  0.608
2016 Jardine JG, Kulp DW, Havenar-Daughton C, Sarkar A, Briney B, Sok D, Sesterhenn F, Ereño-Orbea J, Kalyuzhniy O, Deresa I, Hu X, Spencer S, Jones M, Georgeson E, Adachi Y, ... ... Wilson IA, et al. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen. Science (New York, N.Y.). 351: 1458-63. PMID 27013733 DOI: 10.1126/Science.Aad9195  0.768
2016 Behrens AJ, Vasiljevic S, Pritchard LK, Harvey DJ, Andev RS, Krumm SA, Struwe WB, Cupo A, Kumar A, Zitzmann N, Seabright GE, Kramer HB, Spencer DI, Royle L, Lee JH, ... ... Wilson IA, et al. Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein. Cell Reports. PMID 26972002 DOI: 10.1016/J.Celrep.2016.02.058  0.403
2016 Thornburg NJ, Zhang H, Bangaru S, Sapparapu G, Kose N, Lampley RM, Bombardi RG, Yu Y, Graham S, Branchizio A, Yoder SM, Rock MT, Creech CB, Edwards KM, Lee D, ... ... Wilson IA, et al. H7N9 influenza virus neutralizing antibodies that possess few somatic mutations. The Journal of Clinical Investigation. PMID 26950424 DOI: 10.1172/Jci85317  0.365
2016 McLuskey K, Grewal JS, Das D, Godzik A, Lesley SA, Deacon AM, Coombs GH, Elsliger MA, Wilson IA, Mottram JC. Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome. The Journal of Biological Chemistry. PMID 26940874 DOI: 10.1074/Jbc.M115.706143  0.612
2016 Koday MT, Nelson J, Chevalier A, Koday M, Kalinoski H, Stewart L, Carter L, Nieusma T, Lee PS, Ward AB, Wilson IA, Dagley A, Smee DF, Baker D, Fuller DH. A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response. Plos Pathogens. 12: e1005409. PMID 26845438 DOI: 10.1371/Journal.Ppat.1005409  0.326
2016 Irimia A, Sarkar A, Stanfield RL, Wilson IA. Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10. Immunity. 44: 21-31. PMID 26777395 DOI: 10.1016/J.Immuni.2015.12.001  0.761
2016 Kong L, Ju B, Ren L, Chen Y, Liu J, He L, Hong K, Su B, Wang Z, Ozorowski G, Ji X, Hua Y, Deller MC, Hao Y, Feng Y, ... ... Wilson IA, et al. Critical determinants in the emergence of broadly neutralizing CD4-binding site antibodies from an HIV-1-infected Chinese donor Immunity. DOI: 10.2210/Pdb5Cd3/Pdb  0.355
2015 de Taeye SW, Ozorowski G, Torrents de la Peña A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, ... ... Wilson IA, et al. Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes. Cell. 163: 1702-15. PMID 26687358 DOI: 10.1016/J.Cell.2015.11.056  0.391
2015 Garces F, Lee JH, de Val N, Torrents de la Pena A, Kong L, Puchades C, Hua Y, Stanfield RL, Burton DR, Moore JP, Sanders RW, Ward AB, Wilson IA. Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans. Immunity. 43: 1053-63. PMID 26682982 DOI: 10.1016/J.Immuni.2015.11.007  0.434
2015 Zhu X, Viswanathan K, Raman R, Yu W, Sasisekharan R, Wilson IA. Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Reports. PMID 26586437 DOI: 10.1016/J.Celrep.2015.10.027  0.348
2015 Kong L, Torrents de la Peña A, Deller MC, Garces F, Sliepen K, Hua Y, Stanfield RL, Sanders RW, Wilson IA. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer. Acta Crystallographica. Section D, Biological Crystallography. 71: 2099-108. PMID 26457433 DOI: 10.1107/S1399004715013917  0.453
2015 Lee JH, Leaman DP, Kim AS, Torrents de la Peña A, Sliepen K, Yasmeen A, Derking R, Ramos A, de Taeye SW, Ozorowski G, Klein F, Burton DR, Nussenzweig MC, Poignard P, Moore JP, ... ... Wilson IA, et al. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nature Communications. 6: 8167. PMID 26404402 DOI: 10.1038/Ncomms9167  0.413
2015 Xu Q, Mengin-Lecreulx D, Liu XW, Patin D, Farr CL, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Godzik A, Lesley SA, Elsliger MA, Deacon AM, Wilson IA. Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains. Mbio. 6. PMID 26374125 DOI: 10.1128/Mbio.02327-14  0.337
2015 Julien JP, Lee JH, Ozorowski G, Hua Y, Torrents de la Peña A, de Taeye SW, Nieusma T, Cupo A, Yasmeen A, Golabek M, Pugach P, Klasse PJ, Moore JP, Sanders RW, Ward AB, ... Wilson IA, et al. Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens. Proceedings of the National Academy of Sciences of the United States of America. PMID 26372963 DOI: 10.1073/Pnas.1507793112  0.429
2015 Ringe RP, Yasmeen A, Ozorowski G, Go EP, Pritchard LK, Guttman M, Ketas TA, Cottrell CA, Wilson IA, Sanders RW, Cupo A, Crispin M, Lee KK, Desaire H, Ward AB, et al. Influences on the design and purification of soluble, recombinant native-like HIV-1 envelope glycoprotein trimers. Journal of Virology. PMID 26311893 DOI: 10.1128/Jvi.01768-15  0.406
2015 Impagliazzo A, Milder F, Kuipers H, Wagner MV, Zhu X, Hoffman RM, van Meersbergen R, Huizingh J, Wanningen P, Verspuij J, de Man M, Ding Z, Apetri A, Kükrer B, Sneekes-Vriese E, ... ... Wilson IA, et al. A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. Science (New York, N.Y.). 349: 1301-6. PMID 26303961 DOI: 10.1126/Science.Aac7263  0.354
2015 Peng Y, Zeng W, Ye H, Han KH, Dharmarajan V, Novick S, Wilson IA, Griffin PR, Friedman JM, Lerner RA. A General Method for Insertion of Functional Proteins within Proteins via Combinatorial Selection of Permissive Junctions. Chemistry & Biology. 22: 1134-43. PMID 26278185 DOI: 10.1016/J.Chembiol.2015.07.011  0.312
2015 He L, Cheng Y, Kong L, Azadnia P, Giang E, Kim J, Wood MR, Wilson IA, Law M, Zhu J. Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding. Scientific Reports. 5: 12501. PMID 26238798 DOI: 10.1038/Srep12501  0.367
2015 Dutta SK, Serrano P, Geralt M, Axelrod HL, Xu Q, Lesley SA, Godzik A, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K. Cofactor-induced reversible folding of Flavodoxin-4 from Lactobacillus acidophilus. Protein Science : a Publication of the Protein Society. 24: 1600-8. PMID 26177955 DOI: 10.1002/Pro.2743  0.362
2015 Kong L, Kadam RU, Giang E, Ruwona TB, Nieusma T, Culhane JC, Stanfield RL, Dawson PE, Wilson IA, Law M. Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314-324 in complex with antibody IGH526. Journal of Molecular Biology. PMID 26135247 DOI: 10.1016/J.Jmb.2015.06.012  0.377
2015 Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L, Arendt H, Kim HJ, Lee JH, Pugach P, Williams M, ... ... Wilson IA, et al. HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers. Science (New York, N.Y.). 349: aac4223. PMID 26089353 DOI: 10.1126/Science.Aac4223  0.393
2015 Pritchard LK, Vasiljevic S, Ozorowski G, Seabright GE, Cupo A, Ringe R, Kim HJ, Sanders RW, Doores KJ, Burton DR, Wilson IA, Ward AB, Moore JP, Crispin M. Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers. Cell Reports. 11: 1604-13. PMID 26051934 DOI: 10.1016/J.Celrep.2015.05.017  0.448
2015 Willis JR, Sapparapu G, Murrell S, Julien JP, Singh V, King HG, Xia Y, Pickens JA, LaBranche CC, Slaughter JC, Montefiori DC, Wilson IA, Meiler J, Crowe JE. Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth. The Journal of Clinical Investigation. 125: 2523-31. PMID 25985274 DOI: 10.1172/Jci80693  0.405
2015 Lee PS, Zhu X, Yu W, Wilson IA. Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer. Journal of Virology. 89: 7417-20. PMID 25926650 DOI: 10.1128/Jvi.00808-15  0.333
2015 Deller MC, Johnson HA, Miller MD, Spraggon G, Elsliger MA, Wilson IA, Lesley SA. Crystal structure of a two-subunit TrkA octameric gating ring assembly. Plos One. 10: e0122512. PMID 25826626 DOI: 10.1371/Journal.Pone.0122512  0.33
2015 Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, ... ... Wilson IA, et al. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 4666-71. PMID 25825768 DOI: 10.1073/Pnas.1502855112  0.568
2015 Derking R, Ozorowski G, Sliepen K, Yasmeen A, Cupo A, Torres JL, Julien JP, Lee JH, van Montfort T, de Taeye SW, Connors M, Burton DR, Wilson IA, Klasse PJ, Ward AB, et al. Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer. Plos Pathogens. 11: e1004767. PMID 25807248 DOI: 10.1371/Journal.Ppat.1004767  0.435
2015 Zhang H, de Vries RP, Tzarum N, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA. A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors. Cell Host & Microbe. 17: 377-84. PMID 25766296 DOI: 10.1016/J.Chom.2015.02.006  0.318
2015 Tzarum N, de Vries RP, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA. Structure and receptor binding of the hemagglutinin from a human H6N1 influenza virus. Cell Host & Microbe. 17: 369-76. PMID 25766295 DOI: 10.1016/J.Chom.2015.02.005  0.334
2015 Adhikary R, Yu W, Oda M, Walker RC, Chen T, Stanfield RL, Wilson IA, Zimmermann J, Romesberg FE. Adaptive mutations alter antibody structure and dynamics during affinity maturation. Biochemistry. 54: 2085-93. PMID 25756188 DOI: 10.1021/Bi501417Q  0.359
2015 Lee PS, Arnell AJ, Wilson IA. Structure of the apo anti-influenza CH65 Fab. Acta Crystallographica. Section F, Structural Biology Communications. 71: 145-8. PMID 25664786 DOI: 10.1107/S2053230X14027599  0.406
2015 Guttman M, Cupo A, Julien JP, Sanders RW, Wilson IA, Moore JP, Lee KK. Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env. Nature Communications. 6: 6144. PMID 25652336 DOI: 10.1038/Ncomms7144  0.444
2015 Ward AB, Wilson IA. Insights into the trimeric HIV-1 envelope glycoprotein structure. Trends in Biochemical Sciences. 40: 101-7. PMID 25600289 DOI: 10.1016/J.Tibs.2014.12.006  0.429
2015 Pugach P, Ozorowski G, Cupo A, Ringe R, Yasmeen A, de Val N, Derking R, Kim HJ, Korzun J, Golabek M, de Los Reyes K, Ketas TJ, Julien JP, Burton DR, Wilson IA, et al. A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene. Journal of Virology. 89: 3380-95. PMID 25589637 DOI: 10.1128/Jvi.03473-14  0.428
2015 Kong L, Wilson IA, Kwong PD. Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262. Proteins. 83: 590-6. PMID 25546301 DOI: 10.1002/Prot.24747  0.401
2015 Stanfield RL, De Castro C, Marzaioli AM, Wilson IA, Pantophlet R. Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose. Glycobiology. 25: 412-9. PMID 25380763 DOI: 10.1093/Glycob/Cwu123  0.425
2015 Doores KJ, Kong L, Krumm SA, Le KM, Sok D, Laserson U, Garces F, Poignard P, Wilson IA, Burton DR. Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope. Journal of Virology. 89: 1105-18. PMID 25378488 DOI: 10.1128/Jvi.02905-14  0.443
2015 Lee PS, Wilson IA. Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies. Current Topics in Microbiology and Immunology. 386: 323-41. PMID 25037260 DOI: 10.1007/82_2014_413  0.415
2015 Jiménez-Dalmaroni MJ, Radcliffe CM, Harvey DJ, Wormald MR, Verdino P, Ainge GD, Larsen DS, Painter GF, Ulevitch R, Beutler B, Rudd PM, Dwek RA, Wilson IA. Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunity. 21: 175-93. PMID 24591200 DOI: 10.1177/1753425914524077  0.325
2014 Stanfield RL, Wilson IA. Antibody Structure. Microbiology Spectrum. 2. PMID 26105818 DOI: 10.1128/microbiolspec.AID-0012-2013  0.309
2014 Xu Q, Mengin-Lecreulx D, Patin D, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Godzik A, Lesley SA, Elsliger MA, Deacon AM, Wilson IA. Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family. Structure (London, England : 1993). 22: 1799-809. PMID 25465128 DOI: 10.1016/J.Str.2014.09.018  0.386
2014 Sok D, van Gils MJ, Pauthner M, Julien JP, Saye-Francisco KL, Hsueh J, Briney B, Lee JH, Le KM, Lee PS, Hua Y, Seaman MS, Moore JP, Ward AB, Wilson IA, et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. Proceedings of the National Academy of Sciences of the United States of America. 111: 17624-9. PMID 25422458 DOI: 10.1073/Pnas.1415789111  0.401
2014 Bird GH, Irimia A, Ofek G, Kwong PD, Wilson IA, Walensky LD. Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nature Structural & Molecular Biology. 21: 1058-67. PMID 25420104 DOI: 10.1038/Nsmb.2922  0.418
2014 Bowers PM, Verdino P, Wang Z, da Silva Correia J, Chhoa M, Macondray G, Do M, Neben TY, Horlick RA, Stanfield RL, Wilson IA, King DJ. Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. The Journal of Biological Chemistry. 289: 33557-67. PMID 25320089 DOI: 10.1074/Jbc.M114.607176  0.368
2014 Chiu HJ, Grant JC, Farr CL, Jaroszewski L, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA. Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications. Acta Crystallographica. Section D, Biological Crystallography. 70: 2640-51. PMID 25286848 DOI: 10.1107/S1399004714017052  0.361
2014 Garces F, Sok D, Kong L, McBride R, Kim HJ, Saye-Francisco KF, Julien JP, Hua Y, Cupo A, Moore JP, Paulson JC, Ward AB, Burton DR, Wilson IA. Structural evolution of glycan recognition by a family of potent HIV antibodies. Cell. 159: 69-79. PMID 25259921 DOI: 10.1016/J.Cell.2014.09.009  0.421
2014 Tan GS, Lee PS, Hoffman RM, Mazel-Sanchez B, Krammer F, Leon PE, Ward AB, Wilson IA, Palese P. Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin. Journal of Virology. 88: 13580-92. PMID 25210195 DOI: 10.1128/Jvi.02289-14  0.369
2014 Xu Q, Deller MC, Nielsen TK, Grant JC, Lesley SA, Elsliger MA, Deacon AM, Wilson IA. Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin. Plos One. 9: e107309. PMID 25197798 DOI: 10.1371/Journal.Pone.0107309  0.4
2014 Kumar A, Punta M, Axelrod HL, Das D, Farr CL, Grant JC, Chiu HJ, Miller MD, Coggill PC, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA. Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake. Protein Science : a Publication of the Protein Society. 23: 1380-91. PMID 25044324 DOI: 10.1002/Pro.2522  0.628
2014 Murin CD, Julien JP, Sok D, Stanfield RL, Khayat R, Cupo A, Moore JP, Burton DR, Wilson IA, Ward AB. Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy. Journal of Virology. 88: 10177-88. PMID 24965454 DOI: 10.1128/Jvi.01229-14  0.414
2014 Guttman M, Garcia NK, Cupo A, Matsui T, Julien JP, Sanders RW, Wilson IA, Moore JP, Lee KK. CD4-induced activation in a soluble HIV-1 Env trimer. Structure (London, England : 1993). 22: 974-84. PMID 24931470 DOI: 10.1016/J.Str.2014.05.001  0.33
2014 Collins B, Wilson IA. Crystal structure of the C-terminal domain of mouse TLR9. Proteins. 82: 2874-8. PMID 24888966 DOI: 10.1002/Prot.24616  0.326
2014 Fleischman NM, Das D, Kumar A, Xu Q, Chiu HJ, Jaroszewski L, Knuth MW, Klock HE, Miller MD, Elsliger MA, Godzik A, Lesley SA, Deacon AM, Wilson IA, Toney MD. Molecular characterization of novel pyridoxal-5'-phosphate-dependent enzymes from the human microbiome. Protein Science : a Publication of the Protein Society. 23: 1060-76. PMID 24888348 DOI: 10.1002/Pro.2493  0.559
2014 Yasmeen A, Ringe R, Derking R, Cupo A, Julien JP, Burton DR, Ward AB, Wilson IA, Sanders RW, Moore JP, Klasse PJ. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits. Retrovirology. 11: 41. PMID 24884783 DOI: 10.1186/1742-4690-11-41  0.411
2014 Sok D, Doores KJ, Briney B, Le KM, Saye-Francisco KL, Ramos A, Kulp DW, Julien JP, Menis S, Wickramasinghe L, Seaman MS, Schief WR, Wilson IA, Poignard P, Burton DR. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV. Science Translational Medicine. 6: 236ra63. PMID 24828077 DOI: 10.1126/Scitranslmed.3008104  0.379
2014 Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Peña AT, Cupo A, Julien JP, van Gils M, Lee PS, Peng W, Paulson JC, Poignard P, Burton DR, Moore JP, ... ... Wilson IA, et al. Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers. Immunity. 40: 669-80. PMID 24768348 DOI: 10.1016/J.Immuni.2014.04.008  0.423
2014 Falkowska E, Le KM, Ramos A, Doores KJ, Lee JH, Blattner C, Ramirez A, Derking R, van Gils MJ, Liang CH, Mcbride R, von Bredow B, Shivatare SS, Wu CY, Chan-Hui PY, ... ... Wilson IA, et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers. Immunity. 40: 657-68. PMID 24768347 DOI: 10.1016/J.Immuni.2014.04.009  0.404
2014 Chung NP, Matthews K, Kim HJ, Ketas TJ, Golabek M, de Los Reyes K, Korzun J, Yasmeen A, Sanders RW, Klasse PJ, Wilson IA, Ward AB, Marozsan AJ, Moore JP, Cupo A. Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies. Retrovirology. 11: 33. PMID 24767177 DOI: 10.1186/1742-4690-11-33  0.359
2014 Wyrzucki A, Dreyfus C, Kohler I, Steck M, Wilson IA, Hangartner L. Alternative recognition of the conserved stem epitope in influenza A virus hemagglutinin by a VH3-30-encoded heterosubtypic antibody. Journal of Virology. 88: 7083-92. PMID 24719426 DOI: 10.1128/Jvi.00178-14  0.392
2014 Lee PS, Ohshima N, Stanfield RL, Yu W, Iba Y, Okuno Y, Kurosawa Y, Wilson IA. Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus. Nature Communications. 5: 3614. PMID 24717798 DOI: 10.1038/Ncomms4614  0.386
2014 Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, et al. Complement is activated by IgG hexamers assembled at the cell surface. Science (New York, N.Y.). 343: 1260-3. PMID 24626930 DOI: 10.1126/Science.1248943  0.629
2014 Doria-Rose NA, Schramm CA, Gorman J, Moore PL, Bhiman JN, DeKosky BJ, Ernandes MJ, Georgiev IS, Kim HJ, Pancera M, Staupe RP, Altae-Tran HR, Bailer RT, Crooks ET, Cupo A, ... ... Wilson IA, et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature. 509: 55-62. PMID 24590074 DOI: 10.1038/Nature13036  0.405
2014 Tran K, Poulsen C, Guenaga J, de Val N, de Val Alda N, Wilson R, Sundling C, Li Y, Stanfield RL, Wilson IA, Ward AB, Karlsson Hedestam GB, Wyatt RT. Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign. Proceedings of the National Academy of Sciences of the United States of America. 111: E738-47. PMID 24550318 DOI: 10.1073/Pnas.1319512111  0.402
2014 Grover RK, Zhu X, Nieusma T, Jones T, Boero I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, ... ... Wilson IA, et al. A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union. Science (New York, N.Y.). 343: 656-61. PMID 24503852 DOI: 10.1126/Science.1246135  0.404
2014 Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC, Throsby M, Kwakkenbos MJ, ... ... Wilson IA, et al. A common solution to group 2 influenza virus neutralization. Proceedings of the National Academy of Sciences of the United States of America. 111: 445-50. PMID 24335589 DOI: 10.1073/Pnas.1319058110  0.37
2014 Das D, Chiu HJ, Farr CL, Grant JC, Jaroszewski L, Knuth MW, Miller MD, Tien HJ, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA. Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family. Proteins. 82: 1086-92. PMID 24174223 DOI: 10.1002/Prot.24455  0.585
2014 de Vries RP, Zhu X, McBride R, Rigter A, Hanson A, Zhong G, Hatta M, Xu R, Yu W, Kawaoka Y, de Haan CA, Wilson IA, Paulson JC. Hemagglutinin receptor specificity and structural analyses of respiratory droplet-transmissible H5N1 viruses. Journal of Virology. 88: 768-73. PMID 24173215 DOI: 10.1128/Jvi.02690-13  0.375
2014 Xu Q, Chiu HJ, Farr CL, Jaroszewski L, Knuth MW, Miller MD, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA. Structures of a bifunctional cell wall hydrolase CwlT containing a novel bacterial lysozyme and an NlpC/P60 DL-endopeptidase. Journal of Molecular Biology. 426: 169-84. PMID 24051416 DOI: 10.1016/J.Jmb.2013.09.011  0.357
2014 Xu Q, Grant J, Chiu HJ, Farr CL, Jaroszewski L, Knuth MW, Miller MD, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA. Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site. Proteins. 82: 164-70. PMID 23852666 DOI: 10.1002/Prot.24362  0.369
2014 Wilson I. Broad Neutralization of Viral Pathogens Acta Crystallographica Section a Foundations and Advances. 70: C245-C245. DOI: 10.1107/S205327331409754X  0.46
2014 Stanfield R, Smider V, Wilson I. Bovine antibodies with ultra long H3 Complementarity Determining Regions Acta Crystallographica Section a Foundations and Advances. 70: C255-C255. DOI: 10.1107/S2053273314097447  0.362
2014 Elsliger M, Deacon A, Godzik A, Lesley S, Hodgson K, Wooley J, Wüthrich K, Wilson I. JCSG – Adapting Structural Genomics to Eukaryotic Complexes Acta Crystallographica Section a Foundations and Advances. 70: C1148-C1148. DOI: 10.1107/S2053273314088512  0.322
2014 Das D, Yumoto F, Kuchenbecker K, Deacon A, Fletterick R, Wilson I. Understanding disease mutations from the crystal structure of SOX9 with DNA Acta Crystallographica Section a Foundations and Advances. 70: C1398-C1398. DOI: 10.1107/S205327331408601X  0.574
2014 Lee K, Guttman M, Julien J, Cupo A, Sanders R, Wilson I, Moore J. D-102 The potency of broadly neutralizing antibodies directly relates to their ability to recognize the closed pre-fusion form of HIV Env Jaids Journal of Acquired Immune Deficiency Syndromes. 67: 55. DOI: 10.1097/01.Qai.0000456127.20795.54  0.358
2013 Xu R, de Vries RP, Zhu X, Nycholat CM, McBride R, Yu W, Paulson JC, Wilson IA. Preferential recognition of avian-like receptors in human influenza A H7N9 viruses. Science (New York, N.Y.). 342: 1230-5. PMID 24311689 DOI: 10.1126/Science.1243761  0.322
2013 Kong L, Giang E, Nieusma T, Kadam RU, Cogburn KE, Hua Y, Dai X, Stanfield RL, Burton DR, Ward AB, Wilson IA, Law M. Hepatitis C virus E2 envelope glycoprotein core structure. Science (New York, N.Y.). 342: 1090-4. PMID 24288331 DOI: 10.1126/Science.1243876  0.343
2013 Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, ... ... Wilson IA, et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. Plos Pathogens. 9: e1003754. PMID 24278016 DOI: 10.1371/Journal.Ppat.1003754  0.427
2013 Suh EH, Liu Y, Connelly S, Genereux JC, Wilson IA, Kelly JW. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. Journal of the American Chemical Society. 135: 17869-80. PMID 24180271 DOI: 10.1021/Ja408230K  0.324
2013 Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science (New York, N.Y.). 342: 1484-90. PMID 24179160 DOI: 10.1126/Science.1245627  0.435
2013 Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, Deller MC, Klasse PJ, Burton DR, Sanders RW, Moore JP, Ward AB, Wilson IA. Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science (New York, N.Y.). 342: 1477-83. PMID 24179159 DOI: 10.1126/Science.1245625  0.43
2013 Xu R, Palmer SG, Porotto M, Palermo LM, Niewiesk S, Wilson IA, Moscona A. Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo. Mbio. 4: e00803-13. PMID 24149514 DOI: 10.1128/Mbio.00803-13  0.33
2013 Ringe RP, Sanders RW, Yasmeen A, Kim HJ, Lee JH, Cupo A, Korzun J, Derking R, van Montfort T, Julien JP, Wilson IA, Klasse PJ, Ward AB, Moore JP. Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation. Proceedings of the National Academy of Sciences of the United States of America. 110: 18256-61. PMID 24145402 DOI: 10.1073/Pnas.1314351110  0.384
2013 Das D, Hervé M, Elsliger MA, Kadam RU, Grant JC, Chiu HJ, Knuth MW, Klock HE, Miller MD, Godzik A, Lesley SA, Deacon AM, Mengin-Lecreulx D, Wilson IA. Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling. Journal of Bacteriology. 195: 5555-66. PMID 24123814 DOI: 10.1128/Jb.00900-13  0.622
2013 Bhabha G, Ekiert DC, Jennewein M, Zmasek CM, Tuttle LM, Kroon G, Dyson HJ, Godzik A, Wilson IA, Wright PE. Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nature Structural & Molecular Biology. 20: 1243-9. PMID 24077226 DOI: 10.1038/Nsmb.2676  0.305
2013 Sanders RW, Derking R, Cupo A, Julien JP, Yasmeen A, de Val N, Kim HJ, Blattner C, de la Peña AT, Korzun J, Golabek M, de Los Reyes K, Ketas TJ, van Gils MJ, King CR, ... Wilson IA, et al. A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. Plos Pathogens. 9: e1003618. PMID 24068931 DOI: 10.1371/Journal.Ppat.1003618  0.43
2013 Zhu X, Guo YH, Jiang T, Wang YD, Chan KH, Li XF, Yu W, McBride R, Paulson JC, Yuen KY, Qin CF, Che XY, Wilson IA. A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin. Journal of Virology. 87: 12619-35. PMID 24049169 DOI: 10.1128/Jvi.01577-13  0.4
2013 Hong M, Lee PS, Hoffman RM, Zhu X, Krause JC, Laursen NS, Yoon SI, Song L, Tussey L, Crowe JE, Ward AB, Wilson IA. Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site. Journal of Virology. 87: 12471-80. PMID 24027321 DOI: 10.1128/Jvi.01388-13  0.399
2013 Szent-Gyorgyi C, Stanfield RL, Andreko S, Dempsey A, Ahmed M, Capek S, Waggoner AS, Wilson IA, Bruchez MP. Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces. Journal of Molecular Biology. 425: 4595-613. PMID 23978698 DOI: 10.1016/J.Jmb.2013.08.014  0.373
2013 Talekar A, DeVito I, Salah Z, Palmer SG, Chattopadhyay A, Rose JK, Xu R, Wilson IA, Moscona A, Porotto M. Identification of a region in the stalk domain of the nipah virus receptor binding protein that is critical for fusion activation. Journal of Virology. 87: 10980-96. PMID 23903846 DOI: 10.1128/Jvi.01646-13  0.356
2013 Connelly S, DeMartino JK, Boger DL, Wilson IA. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase. Biochemistry. 52: 5133-44. PMID 23869564 DOI: 10.1021/Bi4005182  0.352
2013 Bale S, Julien JP, Bornholdt ZA, Krois AS, Wilson IA, Saphire EO. Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism. Journal of Virology. 87: 10385-8. PMID 23824825 DOI: 10.1128/Jvi.01452-13  0.587
2013 Klasse PJ, Depetris RS, Pejchal R, Julien JP, Khayat R, Lee JH, Marozsan AJ, Cupo A, Cocco N, Korzun J, Yasmeen A, Ward AB, Wilson IA, Sanders RW, Moore JP. Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein. Journal of Virology. 87: 9873-85. PMID 23824824 DOI: 10.1128/Jvi.01226-13  0.405
2013 Khayat R, Lee JH, Julien JP, Cupo A, Klasse PJ, Sanders RW, Moore JP, Wilson IA, Ward AB. Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers. Journal of Virology. 87: 9865-72. PMID 23824817 DOI: 10.1128/Jvi.01222-13  0.425
2013 Wang F, Ekiert DC, Ahmad I, Yu W, Zhang Y, Bazirgan O, Torkamani A, Raudsepp T, Mwangi W, Criscitiello MF, Wilson IA, Schultz PG, Smider VV. Reshaping antibody diversity. Cell. 153: 1379-93. PMID 23746848 DOI: 10.1016/J.Cell.2013.04.049  0.398
2013 Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, ... ... Wilson IA, et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nature Structural & Molecular Biology. 20: 796-803. PMID 23708606 DOI: 10.1038/Nsmb.2594  0.437
2013 Zhang H, Yea K, Xie J, Ruiz D, Wilson IA, Lerner RA. Selecting agonists from single cells infected with combinatorial antibody libraries. Chemistry & Biology. 20: 734-41. PMID 23706638 DOI: 10.1016/J.Chembiol.2013.04.012  0.34
2013 Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, ... ... Wilson IA, et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. Plos Pathogens. 9: e1003342. PMID 23658524 DOI: 10.1371/Journal.Ppat.1003342  0.452
2013 Laursen NS, Wilson IA. Broadly neutralizing antibodies against influenza viruses. Antiviral Research. 98: 476-83. PMID 23583287 DOI: 10.1016/J.Antiviral.2013.03.021  0.343
2013 Das D, Lee WS, Grant JC, Chiu HJ, Farr CL, Vance J, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Kornfeld S, Wilson IA. Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme. The Journal of Biological Chemistry. 288: 16789-99. PMID 23572527 DOI: 10.1074/Jbc.M112.434977  0.605
2013 Dreyfus C, Ekiert DC, Wilson IA. Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin. Journal of Virology. 87: 7149-54. PMID 23552413 DOI: 10.1128/Jvi.02975-12  0.398
2013 Jardine J, Julien JP, Menis S, Ota T, Kalyuzhniy O, McGuire A, Sok D, Huang PS, MacPherson S, Jones M, Nieusma T, Mathison J, Baker D, Ward AB, Burton DR, ... ... Wilson IA, et al. Rational HIV immunogen design to target specific germline B cell receptors. Science (New York, N.Y.). 340: 711-6. PMID 23539181 DOI: 10.1126/Science.1234150  0.39
2013 Wang F, Sen S, Zhang Y, Ahmad I, Zhu X, Wilson IA, Smider VV, Magliery TJ, Schultz PG. Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation. Proceedings of the National Academy of Sciences of the United States of America. 110: 4261-6. PMID 23440204 DOI: 10.1073/Pnas.1301810110  0.379
2013 Ward AB, Sali A, Wilson IA. Biochemistry. Integrative structural biology. Science (New York, N.Y.). 339: 913-5. PMID 23430643 DOI: 10.1126/Science.1228565  0.305
2013 Julien JP, Lee JH, Cupo A, Murin CD, Derking R, Hoffenberg S, Caulfield MJ, King CR, Marozsan AJ, Klasse PJ, Sanders RW, Moore JP, Wilson IA, Ward AB. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9. Proceedings of the National Academy of Sciences of the United States of America. 110: 4351-6. PMID 23426631 DOI: 10.1073/Pnas.1217537110  0.457
2013 Xu R, Krause JC, McBride R, Paulson JC, Crowe JE, Wilson IA. A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin. Nature Structural & Molecular Biology. 20: 363-70. PMID 23396351 DOI: 10.1038/Nsmb.2500  0.403
2013 Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. Journal of the American Chemical Society. 135: 5656-68. PMID 23350654 DOI: 10.1021/Ja311729D  0.332
2013 Zhu X, Yu W, McBride R, Li Y, Chen LM, Donis RO, Tong S, Paulson JC, Wilson IA. Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities. Proceedings of the National Academy of Sciences of the United States of America. 110: 1458-63. PMID 23297216 DOI: 10.1073/Pnas.1218509110  0.378
2013 Lee JY, Kim HS, Baek IW, Back JM, Han MR, Kong SY, Kim JH, Kirchdoerfer RN, Kim JO, Cooper MD, Wilson IA, Kim HJ, Han BW. Overexpression, crystallization and preliminary X-ray crystallographic analysis of the variable lymphocyte receptor 2913 ectodomain fused with internalin B. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 39-41. PMID 23295483 DOI: 10.1107/S1744309112045484  0.607
2012 Tsibane T, Ekiert DC, Krause JC, Martinez O, Crowe JE, Wilson IA, Basler CF. Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses. Plos Pathogens. 8: e1003067. PMID 23236279 DOI: 10.1371/Journal.Ppat.1003067  0.362
2012 Moeller A, Kirchdoerfer RN, Potter CS, Carragher B, Wilson IA. Organization of the influenza virus replication machinery. Science (New York, N.Y.). 338: 1631-4. PMID 23180774 DOI: 10.1126/Science.1227270  0.311
2012 Burton DR, Ahmed R, Barouch DH, Butera ST, Crotty S, Godzik A, Kaufmann DE, McElrath MJ, Nussenzweig MC, Pulendran B, Scanlan CN, Schief WR, Silvestri G, Streeck H, Walker BD, ... ... Wilson IA, et al. A Blueprint for HIV Vaccine Discovery. Cell Host & Microbe. 12: 396-407. PMID 23084910 DOI: 10.1016/J.Chom.2012.09.008  0.345
2012 Julien JP, Lee PS, Wilson IA. Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA. Immunological Reviews. 250: 180-98. PMID 23046130 DOI: 10.1111/Imr.12005  0.424
2012 Bale S, Julien JP, Bornholdt ZA, Kimberlin CR, Halfmann P, Zandonatti MA, Kunert J, Kroon GJ, Kawaoka Y, MacRae IJ, Wilson IA, Saphire EO. Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. Plos Pathogens. 8: e1002916. PMID 23028316 DOI: 10.1371/Journal.Ppat.1002916  0.625
2012 Lee PS, Yoshida R, Ekiert DC, Sakai N, Suzuki Y, Takada A, Wilson IA. Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity. Proceedings of the National Academy of Sciences of the United States of America. 109: 17040-5. PMID 23027945 DOI: 10.1073/Pnas.1212371109  0.398
2012 Zhang H, Wilson IA, Lerner RA. Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries. Proceedings of the National Academy of Sciences of the United States of America. 109: 15728-33. PMID 23019357 DOI: 10.1073/Pnas.1214275109  0.386
2012 Zhu X, McBride R, Nycholat CM, Yu W, Paulson JC, Wilson IA. Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors. Journal of Virology. 86: 13371-83. PMID 23015718 DOI: 10.1128/Jvi.01426-12  0.347
2012 Zhu X, Yang H, Guo Z, Yu W, Carney PJ, Li Y, Chen LM, Paulson JC, Donis RO, Tong S, Stevens J, Wilson IA. Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site. Proceedings of the National Academy of Sciences of the United States of America. 109: 18903-8. PMID 23012478 DOI: 10.1073/Pnas.1212579109  0.347
2012 Hong M, Yoon Si, Wilson IA. Recombinant expression of TLR5 proteins by ligand supplementation and a leucine-rich repeat hybrid technique Biochemical and Biophysical Research Communications. 427: 119-124. PMID 22989748 DOI: 10.1016/J.Bbrc.2012.09.021  0.302
2012 Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, ... ... Wilson IA, et al. Structure of a novel winged-helix like domain from human NFRKB protein. Plos One. 7: e43761. PMID 22984442 DOI: 10.1371/Journal.Pone.0043761  0.363
2012 Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, ... ... Wilson IA, et al. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature. 489: 526-32. PMID 22982990 DOI: 10.1038/Nature11414  0.44
2012 Kong L, Giang E, Nieusma T, Robbins JB, Deller MC, Stanfield RL, Wilson IA, Law M. Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412 to 423 in complex with antibody AP33. Journal of Virology. 86: 13085-8. PMID 22973046 DOI: 10.1128/Jvi.01939-12  0.371
2012 Buck-Koehntop BA, Stanfield RL, Ekiert DC, Martinez-Yamout MA, Dyson HJ, Wilson IA, Wright PE. Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proceedings of the National Academy of Sciences of the United States of America. 109: 15229-34. PMID 22949637 DOI: 10.1073/Pnas.1213726109  0.314
2012 Schneemann A, Speir JA, Tan GS, Khayat R, Ekiert DC, Matsuoka Y, Wilson IA. A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin. Journal of Virology. 86: 11686-97. PMID 22896619 DOI: 10.1128/Jvi.01694-12  0.383
2012 Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin Ö, ... ... Wilson IA, et al. Highly conserved protective epitopes on influenza B viruses. Science (New York, N.Y.). 337: 1343-8. PMID 22878502 DOI: 10.1126/Science.1222908  0.348
2012 Xu Q, van Wezel GP, Chiu HJ, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA. Structure of an MmyB-like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes. Plos One. 7: e41359. PMID 22844465 DOI: 10.1371/Journal.Pone.0041359  0.309
2012 Burton DR, Poignard P, Stanfield RL, Wilson IA. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science (New York, N.Y.). 337: 183-6. PMID 22798606 DOI: 10.1126/Science.1225416  0.408
2012 Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proceedings of the National Academy of Sciences of the United States of America. 109: 9629-34. PMID 22645360 DOI: 10.1073/Pnas.1121005109  0.332
2012 Depetris RS, Julien JP, Khayat R, Lee JH, Pejchal R, Katpally U, Cocco N, Kachare M, Massi E, David KB, Cupo A, Marozsan AJ, Olson WC, Ward AB, Wilson IA, et al. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers. The Journal of Biological Chemistry. 287: 24239-54. PMID 22645128 DOI: 10.1074/Jbc.M112.371898  0.496
2012 Whitehead TA, Chevalier A, Song Y, Dreyfus C, Fleishman SJ, De Mattos C, Myers CA, Kamisetty H, Blair P, Wilson IA, Baker D. Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nature Biotechnology. 30: 543-8. PMID 22634563 DOI: 10.1038/Nbt.2214  0.348
2012 Kong L, Giang E, Robbins JB, Stanfield RL, Burton DR, Wilson IA, Law M. Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1. Proceedings of the National Academy of Sciences of the United States of America. 109: 9499-504. PMID 22623528 DOI: 10.1073/Pnas.1202924109  0.314
2012 Ekiert DC, Wilson IA. Broadly neutralizing antibodies against influenza virus and prospects for universal therapies Current Opinion in Virology. 2: 134-141. PMID 22482710 DOI: 10.1016/J.Coviro.2012.02.005  0.364
2012 Xu Q, Göhler AK, Kosfeld A, Carlton D, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Jahreis K, Wilson IA. The structure of Mlc titration factor A (MtfA/YeeI) reveals a prototypical zinc metallopeptidase related to anthrax lethal factor. Journal of Bacteriology. 194: 2987-99. PMID 22467785 DOI: 10.1128/Jb.00038-12  0.385
2012 Porotto M, Salah Z, DeVito I, Talekar A, Palmer SG, Xu R, Wilson IA, Moscona A. The second receptor binding site of the globular head of the newcastle disease virus hemagglutinin-neuraminidase activates the stalk of multiple paramyxovirus receptor binding proteins to trigger fusion Journal of Virology. 86: 5730-5741. PMID 22438532 DOI: 10.1128/Jvi.06793-11  0.334
2012 Levisson M, Han GW, Deller MC, Xu Q, Biely P, Hendriks S, Ten Eyck LF, Flensburg C, Roversi P, Miller MD, McMullan D, von Delft F, Kreusch A, Deacon AM, van der Oost J, ... ... Wilson IA, et al. Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima. Proteins. 80: 1545-59. PMID 22411095 DOI: 10.1002/Prot.24041  0.346
2012 Kirchdoerfer RN, Herrin BR, Han BW, Turnbough CL, Cooper MD, Wilson IA. Variable lymphocyte receptor recognition of the immunodominant glycoprotein of Bacillus anthracis spores. Structure (London, England : 1993). 20: 479-86. PMID 22405006 DOI: 10.1016/J.Str.2012.01.009  0.589
2012 Hong M, Yoon SI, Wilson IA. Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator. Immunity. 36: 337-47. PMID 22386589 DOI: 10.1016/J.Immuni.2011.12.018  0.354
2012 Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural basis of TLR5-flagellin recognition and signaling. Science (New York, N.Y.). 335: 859-64. PMID 22344444 DOI: 10.1126/Science.1215584  0.311
2012 Fernandes RA, Shore DA, Vuong MT, Yu C, Zhu X, Pereira-Lopes S, Brouwer H, Fennelly JA, Jessup CM, Evans EJ, Wilson IA, Davis SJ. T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements. The Journal of Biological Chemistry. 287: 13324-35. PMID 22262845 DOI: 10.1074/Jbc.M111.332783  0.387
2012 Xu Q, Christen B, Chiu HJ, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Figurski DH, Shapiro L, Wilson IA. Structure of the pilus assembly protein TadZ from Eubacterium rectale: implications for polar localization. Molecular Microbiology. 83: 712-27. PMID 22211578 DOI: 10.1111/J.1365-2958.2011.07954.X  0.351
2012 Xu R, McBride R, Nycholat CM, Paulson JC, Wilson IA. Structural characterization of the hemagglutinin receptor specificity from the 2009 H1N1 influenza pandemic. Journal of Virology. 86: 982-90. PMID 22072785 DOI: 10.1128/Jvi.06322-11  0.379
2012 Julien J, Kong L, Pejchal R, Khayat R, Lee J, Stanfield R, Walker L, Doores K, Folkowska E, Poignard P, Depetris R, Sanders R, Koff W, Moore J, Ward A, ... ... Wilson I, et al. Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies Retrovirology. 9: P48. DOI: 10.1186/1742-4690-9-S2-P48  0.437
2012 Castro CD, Clark B, Auyeung K, Marzaioli A, Stanfield R, Wilson I, Pantophlet R. Antigenic mimicry of mammalian oligomannose by a naturally occurring bacterial oligosaccharide and its implications for HIV vaccine design Retrovirology. 9: 337. DOI: 10.1186/1742-4690-9-S2-P337  0.394
2011 Soundararajan V, Zheng S, Patel N, Warnock K, Raman R, Wilson IA, Raguram S, Sasisekharan V, Sasisekharan R. Networks link antigenic and receptor-binding sites of influenza hemagglutinin: mechanistic insight into fitter strain propagation. Scientific Reports. 1: 200. PMID 22355715 DOI: 10.1038/Srep00200  0.373
2011 Walker LM, Sok D, Nishimura Y, Donau O, Sadjadpour R, Gautam R, Shingai M, Pejchal R, Ramos A, Simek MD, Geng Y, Wilson IA, Poignard P, Martin MA, Burton DR. Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque. Proceedings of the National Academy of Sciences of the United States of America. 108: 20125-9. PMID 22123961 DOI: 10.1073/Pnas.1117531108  0.35
2011 McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, ... ... Wilson IA, et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 480: 336-43. PMID 22113616 DOI: 10.1038/Nature10696  0.389
2011 Stanfield RL, Julien JP, Pejchal R, Gach JS, Zwick MB, Wilson IA. Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope. Journal of Molecular Biology. 414: 460-76. PMID 22033480 DOI: 10.1016/J.Jmb.2011.10.014  0.404
2011 Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, ... ... Wilson IA, et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science (New York, N.Y.). 334: 1097-103. PMID 21998254 DOI: 10.1126/Science.1213256  0.456
2011 Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Science Translational Medicine. 3: 97ra81. PMID 21865539 DOI: 10.1126/Scitranslmed.3002473  0.315
2011 Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Ramos A, Chan-Hui PY, Moyle M, Mitcham JL, Hammond PW, Olsen OA, Phung P, Fling S, ... ... Wilson IA, et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature. 477: 466-70. PMID 21849977 DOI: 10.1038/Nature10373  0.402
2011 Xu Q, Rawlings ND, Chiu HJ, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA. Structural analysis of papain-like NlpC/P60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites. Plos One. 6: e22013. PMID 21799766 DOI: 10.1371/Journal.Pone.0022013  0.372
2011 Xu Q, Rawlings ND, Farr CL, Chiu HJ, Grant JC, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA. Structural and sequence analysis of Imelysin-Like proteins implicated in bacterial iron uptake Plos One. 6. PMID 21799754 DOI: 10.1371/Journal.Pone.0021875  0.372
2011 Ekiert DC, Friesen RH, Bhabha G, Kwaks T, Jongeneelen M, Yu W, Ophorst C, Cox F, Korse HJ, Brandenburg B, Vogels R, Brakenhoff JP, Kompier R, Koldijk MH, Cornelissen LA, ... ... Wilson IA, et al. A highly conserved neutralizing epitope on group 2 influenza A viruses. Science (New York, N.Y.). 333: 843-50. PMID 21737702 DOI: 10.1126/Science.1204839  0.363
2011 Harris A, Borgnia MJ, Shi D, Bartesaghi A, He H, Pejchal R, Kang Y, Depetris R, Marozsan AJ, Sanders RW, Klasse PJ, Milne JLS, Wilson IA, Olson WC, Moore JP, et al. Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures Proceedings of the National Academy of Sciences of the United States of America. 108: 11440-11445. PMID 21709254 DOI: 10.1073/Pnas.1101414108  0.372
2011 Hothorn M, Belkhadir Y, Dreux M, Dabi T, Noel JP, Wilson IA, Chory J. Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature. 474: 467-71. PMID 21666665 DOI: 10.1038/Nature10153  0.33
2011 Verdino P, Witherden DA, Podshivalova K, Rieder SE, Havran WL, Wilson IA. CDNA sequence and Fab crystal structure of HL4E10, a hamster igG lambda light chain antibody stimulatory for γδ T cells Plos One. 6. PMID 21629689 DOI: 10.1371/Journal.Pone.0019828  0.404
2011 Fleishman SJ, Whitehead TA, Ekiert DC, Dreyfus C, Corn JE, Strauch EM, Wilson IA, Baker D. Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science (New York, N.Y.). 332: 816-21. PMID 21566186 DOI: 10.1126/Science.1202617  0.353
2011 Han GW, Ko J, Farr CL, Deller MC, Xu Q, Chiu HJ, Miller MD, Sefcikova J, Somarowthu S, Beuning PJ, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA, et al. Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity. Proteins. 79: 2146-60. PMID 21538547 DOI: 10.1002/Prot.23035  0.325
2011 Kirchdoerfer RN, Garner AL, Flack CE, Mee JM, Horswill AR, Janda KD, Kaufmann GF, Wilson IA. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. The Journal of Biological Chemistry. 286: 17351-8. PMID 21454495 DOI: 10.1074/Jbc.M111.231258  0.387
2011 Das D, Hervé M, Feuerhelm J, Farr CL, Chiu HJ, Elsliger MA, Knuth MW, Klock HE, Miller MD, Godzik A, Lesley SA, Deacon AM, Mengin-Lecreulx D, Wilson IA. Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein. Plos One. 6: e17624. PMID 21445265 DOI: 10.1371/Journal.Pone.0017624  0.598
2011 Xu R, Wilson IA. Structural characterization of an early fusion intermediate of influenza virus hemagglutinin Journal of Virology. 85: 5172-5182. PMID 21367895 DOI: 10.1128/Jvi.02430-10  0.367
2011 Krause JC, Ekiert DC, Tumpey TM, Smith PB, Wilson IA, Crowe JE. An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody Mbio. 2. PMID 21304166 DOI: 10.1128/Mbio.00345-10  0.408
2011 Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon AM, Lee H, Choi WC, Kim KJ, Kim CH, Kang BS, Lee JO, Oh TK, Kim JW, Wilson IA, Kim MH. Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. The Journal of Biological Chemistry. 286: 12450-60. PMID 21247902 DOI: 10.1074/Jbc.M110.170803  0.376
2011 Verdino P, Witherden DA, Ferguson MS, Corper AL, Schiefner A, Havran WL, Wilson IA. Molecular Insights into γδ T Cell Costimulation by an Anti-JAML Antibody Structure. 19: 80-89. PMID 21220118 DOI: 10.1016/J.Str.2010.10.007  0.398
2011 Verdino P, Witherden DA, Ferguson, Corper AL, Schiefner A, Havran WL, Wilson IA. Molecular Insights into gamma delta T Cell Costimulation by an Anti-JAML Antibody Structure. 19: 80-89. DOI: 10.2210/Pdb3Mj9/Pdb  0.314
2011 Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon A, Lee H, Choi W, Kim K, Kim C, Kang BS, Lee J, Oh T, Kim JW, Wilson IA, Kim MH. Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor Journal of Biological Chemistry. 286: 12450. DOI: 10.2210/Pdb2Xmq/Pdb  0.349
2011 Wilson I. The Joint Center for Structural Genomics: exploration of the human gut microbiome Genome Biology. 12: 1-25. DOI: 10.1186/Gb-2011-12-S1-I18  0.319
2011 Das D, Hervé M, Mengin-Lecreulx D, Deacon A, Wilson IA. Crystal structures of an enzyme duo involved in bacterial cell wall recycling Acta Crystallographica Section a Foundations of Crystallography. 67: C588-C588. DOI: 10.1107/S0108767311085126  0.574
2010 Pejchal R, Wilson IA. Structure-based vaccine design in HIV: blind men and the elephant? Current Pharmaceutical Design. 16: 3744-53. PMID 21128885 DOI: 10.2174/138161210794079173  0.417
2010 Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An αß T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 1996. 274: 209-219. Journal of Immunology (Baltimore, Md. : 1950). 185: 6402-12. PMID 21084669  0.476
2010 Wang TT, Tan GS, Hai R, Pica N, Ngai L, Ekiert DC, Wilson IA, García-Sastre A, Moran TM, Palese P. Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proceedings of the National Academy of Sciences of the United States of America. 107: 18979-84. PMID 20956293 DOI: 10.1073/Pnas.1013387107  0.348
2010 Serrano P, Pedrini B, Geralt M, Jaudzems K, Mohanty B, Horst R, Herrmann T, Elsliger MA, Wilson IA, Wüthrich K. Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1393-405. PMID 20944236 DOI: 10.1107/S1744309110033658  0.385
2010 Mohanty B, Serrano P, Pedrini B, Jaudzems K, Geralt M, Horst R, Herrmann T, Elsliger MA, Wilson IA, Wüthrich K. Comparison of NMR and crystal structures for the proteins TM1112 and TM1367. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1381-92. PMID 20944235 DOI: 10.1107/S1744309110020956  0.357
2010 Jaudzems K, Geralt M, Serrano P, Mohanty B, Horst R, Pedrini B, Elsliger MA, Wilson IA, Wüthrich K. NMR structure of the protein NP_247299.1: comparison with the crystal structure. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1367-80. PMID 20944234 DOI: 10.1107/S1744309110005890  0.354
2010 Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das D, Deller MC, Duan L, Ellrott K, ... ... Wilson IA, et al. Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1354-64. PMID 20944232 DOI: 10.1107/S1744309110021214  0.588
2010 Axelrod HL, Kozbial P, McMullan D, Krishna SS, Miller MD, Abdubek P, Acosta C, Astakhova T, Carlton D, Caruthers J, Chiu HJ, Clayton T, Deller MC, Duan L, Elias Y, ... ... Wilson IA, et al. Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1347-53. PMID 20944231 DOI: 10.1107/S1744309109021988  0.378
2010 Axelrod HL, Das D, Abdubek P, Astakhova T, Bakolitsa C, Carlton D, Chen C, Chiu HJ, Clayton T, Deller MC, Duan L, Ellrott K, Farr CL, Feuerhelm J, Grant JC, ... ... Wilson IA, et al. Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved α+β core domain and an auxiliary C-terminal treble-clef zinc finger. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1335-46. PMID 20944230 DOI: 10.1107/S1744309110020166  0.605
2010 Chiu HJ, Abdubek P, Astakhova T, Axelrod HL, Carlton D, Clayton T, Das D, Deller MC, Duan L, Feuerhelm J, Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, ... ... Wilson IA, et al. The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1317-25. PMID 20944228 DOI: 10.1107/S1744309110021688  0.632
2010 Kumar A, Chiu HJ, Axelrod HL, Morse A, Elsliger MA, Wilson IA, Deacon A. Ligands in PSI structures. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1309-16. PMID 20944227 DOI: 10.1107/S1744309110008092  0.335
2010 Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L, Ellrott K, Farr CL, ... ... Wilson IA, et al. Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1297-305. PMID 20944225 DOI: 10.1107/S1744309110023055  0.584
2010 Yeh AP, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das D, Deller MC, Duan L, Ellrott K, ... ... Wilson IA, et al. Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 Å resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1287-96. PMID 20944224 DOI: 10.1107/S1744309110028228  0.625
2010 Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das D, Deller MC, Duan L, Ellrott K, ... ... Wilson IA, et al. A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Å resolution. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1281-6. PMID 20944223 DOI: 10.1107/S1744309110006548  0.596
2010 Bakolitsa C, Xu Q, Rife CL, Abdubek P, Astakhova T, Axelrod HL, Carlton D, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L, Ellrott K, Farr CL, ... ... Wilson IA, et al. Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1274-80. PMID 20944222 DOI: 10.1107/S1744309110032999  0.632
2010 Das D, Finn RD, Carlton D, Miller MD, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Chen C, Chiu HJ, Chiu M, Clayton T, Deller MC, Duan L, Ellrott K, ... ... Wilson IA, et al. The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1265-73. PMID 20944221 DOI: 10.1107/S1744309109046788  0.581
2010 Das D, Kozbial P, Han GW, Carlton D, Jaroszewski L, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Chen C, Chiu HJ, Chiu M, Clayton T, Deller MC, Duan L, ... ... Wilson IA, et al. The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1254-60. PMID 20944219 DOI: 10.1107/S1744309109018168  0.606
2010 Kumar A, Lomize A, Jin KK, Carlton D, Miller MD, Jaroszewski L, Abdubek P, Astakhova T, Axelrod HL, Chiu HJ, Clayton T, Das D, Deller MC, Duan L, Feuerhelm J, ... ... Wilson IA, et al. Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1245-53. PMID 20944218 DOI: 10.1107/S1744309109042481  0.607
2010 Han GW, Elsliger MA, Yeates TO, Xu Q, Murzin AG, Krishna SS, Jaroszewski L, Abdubek P, Astakhova T, Axelrod HL, Carlton D, Chen C, Chiu HJ, Clayton T, Das D, ... ... Wilson IA, et al. Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1237-44. PMID 20944217 DOI: 10.1107/S1744309110025534  0.633
2010 Xu Q, McMullan D, Jaroszewski L, Krishna SS, Elsliger MA, Yeh AP, Abdubek P, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, Duan L, Feuerhelm J, Grant J, ... ... Wilson IA, et al. Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 Å resolution. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1230-6. PMID 20944216 DOI: 10.1107/S1744309109022192  0.363
2010 Han GW, Bakolitsa C, Miller MD, Kumar A, Carlton D, Najmanovich RJ, Abdubek P, Astakhova T, Axelrod HL, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L, ... ... Wilson IA, et al. Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1218-25. PMID 20944214 DOI: 10.1107/S1744309109050416  0.617
2010 Bakolitsa C, Kumar A, McMullan D, Krishna SS, Miller MD, Carlton D, Najmanovich R, Abdubek P, Astakhova T, Chiu HJ, Clayton T, Deller MC, Duan L, Elias Y, Feuerhelm J, ... ... Wilson IA, et al. The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1211-7. PMID 20944213 DOI: 10.1107/S1744309109022684  0.353
2010 Bakolitsa C, Bateman A, Jin KK, McMullan D, Krishna SS, Miller MD, Abdubek P, Acosta C, Astakhova T, Axelrod HL, Burra P, Carlton D, Chiu HJ, Clayton T, Das D, ... ... Wilson IA, et al. The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1198-204. PMID 20944211 DOI: 10.1107/S1744309109025196  0.589
2010 Bakolitsa C, Kumar A, Jin KK, McMullan D, Krishna SS, Miller MD, Abdubek P, Acosta C, Astakhova T, Axelrod HL, Burra P, Carlton D, Chen C, Chiu HJ, Clayton T, ... ... Wilson IA, et al. Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1182-9. PMID 20944209 DOI: 10.1107/S1744309109050647  0.607
2010 Das D, Grishin NV, Kumar A, Carlton D, Bakolitsa C, Miller MD, Abdubek P, Astakhova T, Axelrod HL, Burra P, Chen C, Chiu HJ, Chiu M, Clayton T, Deller MC, ... ... Wilson IA, et al. The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1174-81. PMID 20944208 DOI: 10.1107/S1744309109022672  0.584
2010 Miller MD, Aravind L, Bakolitsa C, Rife CL, Carlton D, Abdubek P, Astakhova T, Axelrod HL, Chiu HJ, Clayton T, Deller MC, Duan L, Feuerhelm J, Grant JC, Han GW, ... ... Wilson IA, et al. Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1167-73. PMID 20944207 DOI: 10.1107/S1744309110007517  0.386
2010 Krishna SS, Aravind L, Bakolitsa C, Caruthers J, Carlton D, Miller MD, Abdubek P, Astakhova T, Axelrod HL, Chiu HJ, Clayton T, Deller MC, Duan L, Feuerhelm J, Grant JC, ... ... Wilson IA, et al. The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1160-6. PMID 20944206 DOI: 10.1107/S1744309110002514  0.359
2010 Chiu HJ, Bakolitsa C, Skerra A, Lomize A, Carlton D, Miller MD, Krishna SS, Abdubek P, Astakhova T, Axelrod HL, Clayton T, Deller MC, Duan L, Feuerhelm J, Grant JC, ... ... Wilson IA, et al. Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1153-9. PMID 20944205 DOI: 10.1107/S1744309109037749  0.321
2010 Krishna SS, Weekes D, Bakolitsa C, Elsliger MA, Wilson IA, Godzik A, Wooley J. TOPSAN: use of a collaborative environment for annotating, analyzing and disseminating data on JCSG and PSI structures. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1143-7. PMID 20944203 DOI: 10.1107/S1744309110035736  0.331
2010 Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wooley J, Wüthrich K, Wilson IA. The JCSG high-throughput structural biology pipeline. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1137-42. PMID 20944202 DOI: 10.1107/S1744309110038212  0.326
2010 Xu Q, Eguchi T, Mathews II, Rife CL, Chiu HJ, Farr CL, Feuerhelm J, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Weekes D, Elsliger MA, Deacon AM, Godzik A, ... ... Wilson IA, et al. Insights into substrate specificity of geranylgeranyl reductases revealed by the structure of digeranylgeranylglycerophospholipid reductase, an essential enzyme in the biosynthesis of archaeal membrane lipids. Journal of Molecular Biology. 404: 403-17. PMID 20869368 DOI: 10.1016/J.Jmb.2010.09.032  0.36
2010 Doores KJ, Fulton Z, Hong V, Patel MK, Scanlan CN, Wormald MR, Finn MG, Burton DR, Wilson IA, Davis BG. A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity. Proceedings of the National Academy of Sciences of the United States of America. 107: 17107-12. PMID 20852065 DOI: 10.1073/Pnas.1002717107  0.42
2010 Das D, Finn RD, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Deller MC, Duan L, Ellrott K, ... ... Wilson IA, et al. The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu. Protein Science : a Publication of the Protein Society. 19: 2131-40. PMID 20836087 DOI: 10.1002/Pro.497  0.594
2010 Verdino P, Witherden DA, Havran WL, Wilson IA. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science (New York, N.Y.). 329: 1210-4. PMID 20813955 DOI: 10.1126/Science.1187996  0.321
2010 Huber M, Le KM, Doores KJ, Fulton Z, Stanfield RL, Wilson IA, Burton DR. Very few substitutions in a germ line antibody are required to initiate significant domain exchange. Journal of Virology. 84: 10700-7. PMID 20702640 DOI: 10.1128/Jvi.01111-10  0.344
2010 Doores KJ, Fulton Z, Huber M, Wilson IA, Burton DR. Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged. Journal of Virology. 84: 10690-9. PMID 20702629 DOI: 10.1128/Jvi.01110-10  0.403
2010 Pejchal R, Walker LM, Stanfield RL, Phogat SK, Koff WC, Poignard P, Burton DR, Wilson IA. Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proceedings of the National Academy of Sciences of the United States of America. 107: 11483-8. PMID 20534513 DOI: 10.1073/Pnas.1004600107  0.466
2010 Dermoun Z, Foulon A, Miller MD, Harrington DJ, Deacon AM, Sebban-Kreuzer C, Roche P, Lafitte D, Bornet O, Wilson IA, Dolla A. TM0486 from the hyperthermophilic anaerobe Thermotoga maritima is a thiamin-binding protein involved in response of the cell to oxidative conditions. Journal of Molecular Biology. 400: 463-76. PMID 20471400 DOI: 10.1016/J.Jmb.2010.05.014  0.334
2010 Yoshida K, Corper AL, Herro R, Jabri B, Wilson IA, Teyton L. The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity. The Journal of Clinical Investigation. 120: 1578-90. PMID 20407212 DOI: 10.1172/Jci41502  0.327
2010 Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, ... Wilson IA, et al. Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. Structure (London, England : 1993). 18: 537-47. PMID 20399190 DOI: 10.1016/J.Str.2010.02.007  0.318
2010 Xu R, Ekiert DC, Krause JC, Hai R, Crowe JE, Wilson IA. Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. Science (New York, N.Y.). 328: 357-60. PMID 20339031 DOI: 10.1126/Science.1186430  0.355
2010 Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA. Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. Current Opinion in Structural Biology. 20: 54-62. PMID 20133122 DOI: 10.1016/J.Sbi.2009.12.009  0.328
2010 Das D, Moiani D, Axelrod HL, Miller MD, McMullan D, Jin KK, Abdubek P, Astakhova T, Burra P, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, Ernst D, ... ... Wilson IA, et al. Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair. Journal of Molecular Biology. 397: 647-63. PMID 20122942 DOI: 10.1016/J.Jmb.2010.01.049  0.571
2010 Choi S, Connelly S, Reixach N, Wilson IA, Kelly JW. Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nature Chemical Biology. 6: 133-9. PMID 20081815 DOI: 10.1038/Nchembio.281  0.348
2010 Scheeff ED, Axelrod HL, Miller MD, Chiu HJ, Deacon AM, Wilson IA, Manning G. Genomics, evolution, and crystal structure of a new family of bacterial spore kinases. Proteins. 78: 1470-82. PMID 20077512 DOI: 10.1002/Prot.22663  0.35
2010 Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. Journal of the American Chemical Society. 132: 1359-70. PMID 20043671 DOI: 10.1021/Ja908562Q  0.33
2010 Xu R, McBride R, Paulson JC, Basler CF, Wilson IA. Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic. Journal of Virology. 84: 1715-21. PMID 20007271 DOI: 10.1128/Jvi.02162-09  0.407
2010 Xu Q, Bateman A, Finn RD, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das D, Deller MC, Duan L, ... ... Wilson IA, et al. Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain. Journal of Molecular Biology. 396: 31-46. PMID 19913036 DOI: 10.1016/J.Jmb.2009.11.006  0.573
2010 Schiefner A, Wilson IA. Presentation of lipid antigens by CD1 glycoproteins. Current Pharmaceutical Design. 15: 3311-7. PMID 19860680 DOI: 10.2174/138161209789105108  0.368
2010 Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex Journal of Immunology. 185: 209-219. DOI: 10.1126/science.274.5285.209  0.489
2009 Zhu X, Tanaka F, Lerner RA, Barbas CF, Wilson IA. Direct observation of an enamine intermediate in amine catalysis. Journal of the American Chemical Society. 131: 18206-7. PMID 19968282 DOI: 10.1021/Ja907271A  0.388
2009 Landais E, Romagnoli PA, Corper AL, Shires J, Altman JD, Wilson IA, Garcia KC, Teyton L. New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation. Journal of Immunology (Baltimore, Md. : 1950). 183: 7949-57. PMID 19923463 DOI: 10.4049/Jimmunol.0902493  0.554
2009 Debler EW, Müller R, Hilvert D, Wilson IA. An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket. Proceedings of the National Academy of Sciences of the United States of America. 106: 18539-44. PMID 19846764 DOI: 10.1073/Pnas.0902700106  0.723
2009 Schiefner A, Fujio M, Wu D, Wong CH, Wilson IA. Structural evaluation of potent NKT cell agonists: implications for design of novel stimulatory ligands. Journal of Molecular Biology. 394: 71-82. PMID 19732779 DOI: 10.1016/J.Jmb.2009.08.061  0.322
2009 Xu Q, Traag BA, Willemse J, McMullan D, Miller MD, Elsliger MA, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Carlton D, Chen C, Chiu HJ, Chruszcz M, Clayton T, ... ... Wilson IA, et al. Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes. The Journal of Biological Chemistry. 284: 25268-79. PMID 19567872 DOI: 10.1074/Jbc.M109.018564  0.62
2009 Pejchal R, Gach JS, Brunel FM, Cardoso RM, Stanfield RL, Dawson PE, Burton DR, Zwick MB, Wilson IA. A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies. Journal of Virology. 83: 8451-62. PMID 19515770 DOI: 10.1128/Jvi.00685-09  0.452
2009 Xu Q, Carlton D, Miller MD, Elsliger MA, Krishna SS, Abdubek P, Astakhova T, Burra P, Chiu HJ, Clayton T, Deller MC, Duan L, Elias Y, Feuerhelm J, Grant JC, ... ... Wilson IA, et al. Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus. Journal of Molecular Biology. 390: 686-98. PMID 19450606 DOI: 10.1016/J.Jmb.2009.05.023  0.344
2009 Kwong PD, Wilson IA. HIV-1 and influenza antibodies: Seeing antigens in new ways Nature Immunology. 10: 573-578. PMID 19448659 DOI: 10.1038/Ni.1746  0.373
2009 An Y, Chen CY, Moyer B, Rotkiewicz P, Elsliger MA, Godzik A, Wilson IA, Balch WE. Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering. Journal of Molecular Biology. 391: 26-41. PMID 19414022 DOI: 10.1016/J.Jmb.2009.04.062  0.333
2009 Zheng M, Cooper DR, Grossoehme NE, Yu M, Hung LW, Cieslik M, Derewenda U, Lesley SA, Wilson IA, Giedroc DP, Derewenda ZS. Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains. Acta Crystallographica. Section D, Biological Crystallography. 65: 356-65. PMID 19307717 DOI: 10.1107/S0907444909004727  0.354
2009 Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. Antibody recognition of a highly conserved influenza virus epitope. Science (New York, N.Y.). 324: 246-51. PMID 19251591 DOI: 10.1126/Science.1171491  0.373
2009 Xu Q, Sudek S, McMullan D, Miller MD, Geierstanger B, Jones DH, Krishna SS, Spraggon G, Bursalay B, Abdubek P, Acosta C, Ambing E, Astakhova T, Axelrod HL, Carlton D, ... ... Wilson IA, et al. Structural basis of murein peptide specificity of a gamma-D-glutamyl-l-diamino acid endopeptidase. Structure (London, England : 1993). 17: 303-13. PMID 19217401 DOI: 10.1016/J.Str.2008.12.008  0.348
2009 Schwede T, Sali A, Honig B, Levitt M, Berman HM, Jones D, Brenner SE, Burley SK, Das R, Dokholyan NV, Dunbrack RL, Fidelis K, Fiser A, Godzik A, Huang YJ, ... ... Wilson IA, et al. Outcome of a workshop on applications of protein models in biomedical research. Structure (London, England : 1993). 17: 151-9. PMID 19217386 DOI: 10.1016/J.Str.2008.12.014  0.458
2009 Das D, Kozbial P, Axelrod HL, Miller MD, McMullan D, Krishna SS, Abdubek P, Acosta C, Astakhova T, Burra P, Carlton D, Chen C, Chiu HJ, Clayton T, Deller MC, ... ... Wilson IA, et al. Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 A resolution. Proteins. 75: 296-307. PMID 19173316 DOI: 10.1002/Prot.22360  0.605
2009 Das D, Krishna SS, McMullan D, Miller MD, Xu Q, Abdubek P, Acosta C, Astakhova T, Axelrod HL, Burra P, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, ... ... Wilson IA, et al. Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 A resolution. Proteins. 75: 264-71. PMID 19127588 DOI: 10.1002/Prot.22338  0.596
2009 Xu Q, Rife CL, Carlton D, Miller MD, Krishna SS, Elsliger MA, Abdubek P, Astakhova T, Chiu HJ, Clayton T, Duan L, Feuerhelm J, Grzechnik SK, Hale J, Han GW, ... ... Wilson IA, et al. Crystal structure of a novel archaeal AAA+ ATPase SSO1545 from Sulfolobus solfataricus. Proteins. 74: 1041-9. PMID 19089981 DOI: 10.1002/Prot.22325  0.373
2009 Xu Q, McMullan D, Abdubek P, Astakhova T, Carlton D, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L, Elsliger MA, Feuerhelm J, Hale J, Han GW, ... ... Wilson IA, et al. A structural basis for the regulatory inactivation of DnaA. Journal of Molecular Biology. 385: 368-80. PMID 19000695 DOI: 10.1016/J.Jmb.2008.10.059  0.623
2009 Fulton Z, Doores KJ, Scanlan CN, Wormald MR, Dwek RA, Wilson IA, Davis BG. P19-03. Molecular mechanisms for enhancing the antigenicity of the carbohydrate epitope of the broadly neutralizing anti-HIV-1 antibody 2G12 Retrovirology. 6: P323. DOI: 10.1186/1742-4690-6-S3-P323  0.315
2009 Doores KJ, Fulton Z, Scanlan CN, Wormald MR, Dwek RA, Wilson IA, Burton DR, Davis BG. P12-06. A 'non-self' mimic of the natural epitope of anti-HIV antibody 2G12 shows enhanced antigenicity Retrovirology. 6: P172. DOI: 10.1186/1742-4690-6-S3-P172  0.35
2008 Zajonc DM, Striegl H, Dascher CC, Wilson IA. The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1 Proceedings of the National Academy of Sciences of the United States of America. 105: 17925-17930. PMID 19004781 DOI: 10.1073/Pnas.0809814105  0.368
2008 Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure (London, England : 1993). 16: 1659-67. PMID 19000818 DOI: 10.1016/J.Str.2008.08.018  0.321
2008 Shore DA, Issafras H, Landais E, Teyton L, Wilson IA. The Crystal Structure of CD8 in Complex with YTS156.7.7 Fab and Interaction with Other CD8 Antibodies Define the Binding Mode of CD8 αβ to MHC Class I Journal of Molecular Biology. 384: 1190-1202. PMID 18929574 DOI: 10.1016/J.Jmb.2008.09.069  0.405
2008 Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science (New York, N.Y.). 321: 1834-7. PMID 18818359 DOI: 10.1126/Science.1162484  0.609
2008 Yu X, Tsibane T, McGraw PA, House FS, Keefer CJ, Hicar MD, Tumpey TM, Pappas C, Perrone LA, Martinez O, Stevens J, Wilson IA, Aguilar PV, Altschuler EL, Basler CF, et al. Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. Nature. 455: 532-6. PMID 18716625 DOI: 10.1038/Nature07231  0.363
2008 Xu X, Zhu X, Dwek RA, Stevens J, Wilson IA. Structural characterization of the 1918 influenza virus H1N1 neuraminidase. Journal of Virology. 82: 10493-501. PMID 18715929 DOI: 10.1128/Jvi.00959-08  0.332
2008 Verdino P, Aldag C, Hilvert D, Wilson IA. Closely related antibody receptors exploit fundamentally different strategies for steroid recognition Proceedings of the National Academy of Sciences of the United States of America. 105: 11725-11730. PMID 18689687 DOI: 10.1073/Pnas.0801783105  0.403
2008 Stevens J, Blixt O, Chen LM, Donis RO, Paulson JC, Wilson IA. Recent Avian H5N1 Viruses Exhibit Increased Propensity for Acquiring Human Receptor Specificity Journal of Molecular Biology. 381: 1382-1394. PMID 18672252 DOI: 10.1016/J.Jmb.2008.04.016  0.315
2008 Zhu X, Xu X, Wilson IA. Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects Acta Crystallographica Section D: Biological Crystallography. 64: 843-850. PMID 18645233 DOI: 10.1107/S0907444908016648  0.351
2008 Dhillon AK, Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA. Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set Acta Crystallographica Section D: Biological Crystallography. 64: 792-802. PMID 18566514 DOI: 10.1107/S0907444908013978  0.434
2008 Astronomo RD, Lee HK, Scanlan CN, Pantophlet R, Huang CY, Wilson IA, Blixt O, Dwek RA, Wong CH, Burton DR. A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120. Journal of Virology. 82: 6359-68. PMID 18434393 DOI: 10.1128/Jvi.00293-08  0.42
2008 Wei CJ, Xu L, Kong WP, Shi W, Canis K, Stevens J, Yang ZY, Dell A, Haslam SM, Wilson IA, Nabel GJ. Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus. Journal of Virology. 82: 6200-8. PMID 18417563 DOI: 10.1128/Jvi.00187-08  0.375
2008 Debler EW, Müller R, Hilvert D, Wilson IA. Conformational isomerism can limit antibody catalysis. The Journal of Biological Chemistry. 283: 16554-60. PMID 18417480 DOI: 10.1074/Jbc.M710256200  0.748
2008 Kozbial P, Xu Q, Chiu HJ, McMullan D, Krishna SS, Miller MD, Abdubek P, Acosta C, Astakhova T, Axelrod HL, Carlton D, Clayton T, Deller M, Duan L, Elias Y, ... ... Wilson IA, et al. Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold. Proteins. 71: 1589-96. PMID 18324683 DOI: 10.1002/Prot.22020  0.336
2008 Debler EW, Kaufmann GF, Meijler MM, Heine A, Mee JM, Pljevaljcic G, Di Bilio AJ, Schultz PG, Millar DP, Janda KD, Wilson IA, Gray HB, Lerner RA. Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (New York, N.Y.). 319: 1232-5. PMID 18309081 DOI: 10.1126/Science.1153445  0.717
2008 Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L. Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids Journal of Molecular Biology. 377: 1104-1116. PMID 18295796 DOI: 10.1016/J.Jmb.2008.01.061  0.345
2008 Xu Q, Kozbial P, McMullan D, Krishna SS, Brittain SM, Ficarro SB, DiDonato M, Miller MD, Abdubek P, Axelrod HL, Chiu HJ, Clayton T, Duan L, Elsliger MA, Feuerhelm J, ... ... Wilson IA, et al. Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution. Proteins. 71: 1546-52. PMID 18275082 DOI: 10.1002/Prot.21992  0.355
2008 Axelrod HL, McMullan D, Krishna SS, Miller MD, Elsliger MA, Abdubek P, Ambing E, Astakhova T, Carlton D, Chiu HJ, Clayton T, Duan L, Feuerhelm J, Grzechnik SK, Hale J, ... ... Wilson IA, et al. Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution. Proteins. 71: 1042-9. PMID 18260100 DOI: 10.1002/Prot.21967  0.337
2008 Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, ... ... Wilson IA, et al. Protein production and purification. Nature Methods. 5: 135-46. PMID 18235434 DOI: 10.1038/Nmeth.F.202  0.471
2008 Menendez A, Calarese DA, Stanfield RL, Chow KC, Scanlan CN, Kunert R, Katinger H, Burton DR, Wilson IA, Scott JK. A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1380-92. PMID 18198210 DOI: 10.1096/Fj.07-8983Com  0.809
2008 Burley SK, Joachimiak A, Montelione GT, Wilson IA. Contributions to the NIH-NIGMS Protein Structure Initiative from the PSI Production Centers Structure. 16: 5-11. PMID 18184575 DOI: 10.1016/J.Str.2007.12.002  0.516
2008 Johnson SM, Connelly S, Wilson IA, Kelly JW. Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. Journal of Medicinal Chemistry. 51: 260-70. PMID 18095641 DOI: 10.1021/Jm0708735  0.309
2008 Bell CH, Pantophlet R, Schiefner A, Cavacini LA, Stanfield RL, Burton DR, Wilson IA. Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization. Journal of Molecular Biology. 375: 969-78. PMID 18068724 DOI: 10.1016/J.Jmb.2007.11.013  0.436
2008 Mathews II, McMullan D, Miller MD, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, McPhillips TM, Morse AT, ... ... Wilson IA, et al. Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution. Proteins. 70: 603-8. PMID 18004772 DOI: 10.1002/Prot.21842  0.309
2007 Slabinski L, Jaroszewski L, Rodrigues APC, Rychlewski L, Wilson IA, Lesley SA, Godzik A. The challenge of protein structure determination - Lessons from structural genomics Protein Science. 16: 2472-2482. PMID 17962404 DOI: 10.1110/Ps.073037907  0.35
2007 Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD. Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science (New York, N.Y.). 317: 1930-4. PMID 17901336 DOI: 10.1126/Science.1145373  0.405
2007 Burton DR, Wilson IA. Immunology: Square-dancing antibodies Science. 317: 1507-1508. PMID 17872431 DOI: 10.1126/Science.1148905  0.323
2007 Stoll R, Lee BM, Debler EW, Laity JH, Wilson IA, Dyson HJ, Wright PE. Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA. Journal of Molecular Biology. 372: 1227-45. PMID 17716689 DOI: 10.1016/J.Jmb.2007.07.017  0.723
2007 Huang S, Romanchuk G, Pattridge K, Lesley SA, Wilson IA, Matthews RG, Ludwig M. Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269. Protein Science : a Publication of the Protein Society. 16: 1588-95. PMID 17656578 DOI: 10.1110/Ps.072936307  0.353
2007 Xu Q, Saikatendu KS, Krishna SS, McMullan D, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Elsliger MA, ... ... Wilson IA, et al. Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 angstroms resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate. Proteins. 69: 433-9. PMID 17654724 DOI: 10.1002/Prot.21602  0.355
2007 Zubieta C, Joseph R, Krishna SS, McMullan D, Kapoor M, Axelrod HL, Miller MD, Abdubek P, Acosta C, Astakhova T, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, ... ... Wilson IA, et al. Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA. Proteins. 69: 234-43. PMID 17654547 DOI: 10.1002/Prot.21673  0.372
2007 Zubieta C, Krishna SS, Kapoor M, Kozbial P, McMullan D, Axelrod HL, Miller MD, Abdubek P, Ambing E, Astakhova T, Carlton D, Chiu HJ, Clayton T, Deller MC, Duan L, ... ... Wilson IA, et al. Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif. Proteins. 69: 223-33. PMID 17654545 DOI: 10.1002/Prot.21550  0.401
2007 Krishna SS, Tautz L, Xu Q, McMullan D, Miller MD, Abdubek P, Ambing E, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Elsliger MA, ... ... Wilson IA, et al. Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 angstroms resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases. Proteins. 69: 415-21. PMID 17636569 DOI: 10.1002/Prot.21314  0.359
2007 Zajonc DM, Wilson IA. Architecture of CD1 proteins Current Topics in Microbiology and Immunology. 314: 27-50. PMID 17593656 DOI: 10.1007/978-3-540-69511-0_2  0.352
2007 Zubieta C, Krishna SS, McMullan D, Miller MD, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, Deller M, DiDonato M, Duan L, ... ... Wilson IA, et al. Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 A resolution. Proteins. 68: 999-1005. PMID 17546672 DOI: 10.1002/Prot.21208  0.301
2007 Sanguineti S, Centeno Crowley JM, Lodeiro Merlo MF, Cerutti ML, Wilson IA, Goldbaum FA, Stanfield RL, de Prat-Gay G. Specific Recognition of a DNA Immunogen by its Elicited Antibody Journal of Molecular Biology. 370: 183-195. PMID 17512945 DOI: 10.1016/J.Jmb.2007.04.046  0.392
2007 Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies. Journal of Molecular Biology. 369: 696-709. PMID 17445828 DOI: 10.1016/J.Jmb.2007.01.060  0.656
2007 Premkumar L, Rife CL, Sri Krishna S, McMullan D, Miller MD, Abdubek P, Ambing E, Astakhova T, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, ... ... Wilson IA, et al. Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function. Proteins. 68: 418-24. PMID 17444523 DOI: 10.1002/Prot.21436  0.328
2007 Debler EW, Kaufmann GF, Kirchdoerfer RN, Mee JM, Janda KD, Wilson IA. Crystal structures of a quorum-quenching antibody. Journal of Molecular Biology. 368: 1392-402. PMID 17400249 DOI: 10.1016/J.Jmb.2007.02.081  0.761
2007 Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. The Journal of Biological Chemistry. 282: 13033-46. PMID 17324932 DOI: 10.1074/Jbc.M607293200  0.36
2007 Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RM, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB. An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10. Journal of Virology. 81: 4033-43. PMID 17287272 DOI: 10.1128/Jvi.02588-06  0.405
2007 Law M, Cardoso RM, Wilson IA, Burton DR. Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy. Journal of Virology. 81: 4272-85. PMID 17267498 DOI: 10.1128/Jvi.02536-06  0.408
2007 Stanfield RL, Dooley H, Verdino P, Flajnik MF, Wilson IA. Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding. Journal of Molecular Biology. 367: 358-72. PMID 17258766 DOI: 10.1016/J.Jmb.2006.12.045  0.39
2007 Weekes D, Miller MD, Krishna SS, McMullan D, McPhillips TM, Acosta C, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, ... ... Wilson IA, et al. Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 A resolution. Proteins. 67: 247-52. PMID 17256761 DOI: 10.1002/Prot.21221  0.313
2007 Müller R, Debler EW, Steinmann M, Seebeck FP, Wilson IA, Hilvert D. Bifunctional catalysis of proton transfer at an antibody active site. Journal of the American Chemical Society. 129: 460-1. PMID 17226987 DOI: 10.1021/Ja066578B  0.749
2007 Cardoso RM, Brunel FM, Ferguson S, Zwick M, Burton DR, Dawson PE, Wilson IA. Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. Journal of Molecular Biology. 365: 1533-44. PMID 17125793 DOI: 10.1016/J.Jmb.2006.10.088  0.378
2007 Lazoura E, Lodding J, Farrugia W, Ramsland PA, Stevens J, Wilson IA, Pietersz GA, Apostolopoulos V. Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide. Immunology. 119: 306-16. PMID 17067310 DOI: 10.1111/J.1365-2567.2006.02434.X  0.336
2007 Wilson IA. High throughput structural genomics and its general applicability to structural biology Acta Crystallographica Section a Foundations of Crystallography. 63: s13-s13. DOI: 10.1107/S0108767307099734  0.327
2006 Tian F, Debler EW, Millar DP, Deniz AA, Wilson IA, Schultz PG. The effects of antibodies on stilbene excited-state energetics. Angewandte Chemie (International Ed. in English). 45: 7763-5. PMID 17089439 DOI: 10.1002/Anie.200602720  0.702
2006 Kosloff M, Han GW, Krishna SS, Schwarzenbacher R, Fasnacht M, Elsliger MA, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, ... ... Wilson IA, et al. Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution. Proteins. 65: 527-37. PMID 16988933 DOI: 10.1002/Prot.21130  0.363
2006 Zajonc DM, Ainge GD, Painter GF, Severn WB, Wilson IA. Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d. Journal of Immunology (Baltimore, Md. : 1950). 177: 4577-83. PMID 16982895 DOI: 10.4049/Jimmunol.177.7.4577  0.338
2006 Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Molecular Pharmacology. 70: 1885-91. PMID 16968810 DOI: 10.1124/Mol.106.025999  0.561
2006 Xu Q, Krishna SS, McMullan D, Schwarzenbacher R, Miller MD, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, ... ... Wilson IA, et al. Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins. 65: 777-82. PMID 16948158 DOI: 10.1002/Prot.21015  0.373
2006 Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Jaroszewski L, Miller MD, Abdubek P, Agarwalla S, Ambing E, Axelrod HL, Canaves JM, Carlton D, Chiu HJ, Clayton T, DiDonato M, ... ... Wilson IA, et al. Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution. Proteins. 65: 249-54. PMID 16865708 DOI: 10.1002/Prot.21024  0.326
2006 Schwarzenbacher R, McMullan D, Krishna SS, Xu Q, Miller MD, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, ... ... Wilson IA, et al. Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold. Proteins. 65: 243-8. PMID 16865707 DOI: 10.1002/Prot.21058  0.321
2006 Binley JM, Ngo-Abdalla S, Moore P, Bobardt M, Chatterji U, Gallay P, Burton DR, Wilson IA, Elder JH, de Parseval A. Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120. Retrovirology. 3: 39. PMID 16817962 DOI: 10.1186/1742-4690-3-39  0.391
2006 Xu Q, Schwarzenbacher R, Krishna SS, McMullan D, Agarwalla S, Quijano K, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Elsliger MA, Grittini C, Grzechnik SK, ... ... Wilson IA, et al. Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution. Proteins. 64: 808-13. PMID 16783794 DOI: 10.1002/Prot.20947  0.333
2006 Han GW, Sri Krishna S, Schwarzenbacher R, McMullan D, Ginalski K, Elsliger MA, Brittain SM, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod H, Canaves JM, Chiu HJ, DiDonato M, ... ... Wilson IA, et al. Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 A resolution. Proteins. 64: 1083-90. PMID 16779835 DOI: 10.1002/Prot.20950  0.345
2006 Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA. Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity. Journal of Virology. 80: 6093-105. PMID 16731948 DOI: 10.1128/Jvi.00205-06  0.406
2006 Johnson MA, Peti W, Herrmann T, Wilson IA, Wüthrich K. Solution structure of Asl1650, an acyl carrier protein from Anabaena sp. PCC 7120 with a variant phosphopantetheinylation-site sequence. Protein Science : a Publication of the Protein Society. 15: 1030-41. PMID 16597827 DOI: 10.1110/Ps.051964606  0.335
2006 Rudolph MG, Stanfield RL, Wilson IA. How TCRs bind MHCs, peptides, and coreceptors. Annual Review of Immunology. 24: 419-66. PMID 16551255 DOI: 10.1146/Annurev.Immunol.23.021704.115658  0.402
2006 Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hale J, ... ... Wilson IA, et al. Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution. Proteins. 63: 1106-11. PMID 16544324 DOI: 10.1002/Prot.20650  0.318
2006 Jin KK, Krishna SS, Schwarzenbacher R, McMullan D, Abdubek P, Agarwalla S, Ambing E, Axelrod H, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Feuerhelm J, Godzik A, ... ... Wilson IA, et al. Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 63: 1112-8. PMID 16544291 DOI: 10.1002/Prot.20894  0.356
2006 Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA. Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus Science. 312: 404-410. PMID 16543414 DOI: 10.1126/Science.1124513  0.319
2006 Wu D, Zajonc DM, Fujio M, Sullivan BA, Kinjo Y, Kronenberg M, Wilson IA, Wong CH. Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proceedings of the National Academy of Sciences of the United States of America. 103: 3972-7. PMID 16537470 DOI: 10.1073/Pnas.0600285103  0.353
2006 Zhu X, Wentworth P, Kyle RA, Lerner RA, Wilson IA. Cofactor-containing antibodies: crystal structure of the original yellow antibody. Proceedings of the National Academy of Sciences of the United States of America. 103: 3581-5. PMID 16537445 DOI: 10.1073/Pnas.0600251103  0.434
2006 Shore DA, Teyton L, Dwek RA, Rudd PM, Wilson IA. Crystal Structure of the TCR Co-receptor CD8αα in Complex with Monoclonal Antibody YTS 105.18 Fab Fragment at 2.88 Å Resolution Journal of Molecular Biology. 358: 347-354. PMID 16530222 DOI: 10.1016/J.Jmb.2006.02.016  0.427
2006 Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proceedings of the National Academy of Sciences of the United States of America. 103: 2788-93. PMID 16477002 DOI: 10.1073/Pnas.0511161103  0.672
2006 Zhu X, Dickerson TJ, Rogers CJ, Kaufmann GF, Mee JM, McKenzie KM, Janda KD, Wilson IA. Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure (London, England : 1993). 14: 205-16. PMID 16472740 DOI: 10.1016/J.Str.2005.10.014  0.326
2006 Brunel FM, Zwick MB, Cardoso RM, Nelson JD, Wilson IA, Burton DR, Dawson PE. Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody. Journal of Virology. 80: 1680-7. PMID 16439525 DOI: 10.1128/Jvi.80.4.1680-1687.2006  0.413
2006 DiDonato M, Krishna SS, Schwarzenbacher R, McMullan D, Jaroszewski L, Miller MD, Abdubek P, Agarwalla S, Ambing E, Axelrod H, Biorac T, Chiu HJ, Deacon AM, Elsliger MA, Feuerhelm J, ... ... Wilson IA, et al. Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 A resolution. Proteins. 63: 256-60. PMID 16435371 DOI: 10.1002/Prot.20841  0.347
2006 Scanlan C, Calarese D, Lee HK, Blixt O, Wong CH, Wilson I, Burton D, Dwek R, Rudd P. Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design. Advances in Experimental Medicine and Biology. 564: 7-8. PMID 16400800 DOI: 10.1007/0-387-25515-X_4  0.805
2006 Stevens J, Blixt O, Glaser L, Taubenberger JK, Palese P, Paulson JC, Wilson IA. Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities. Journal of Molecular Biology. 355: 1143-55. PMID 16343533 DOI: 10.1016/J.Jmb.2005.11.002  0.323
2006 Xu Q, Schwarzenbacher R, McMullan D, Abdubek P, Agarwalla S, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Wilson IA, et al. Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold. Proteins. 62: 292-6. PMID 16287129 DOI: 10.1002/Prot.20611  0.329
2006 Lesley SA, Wilson IA. Protein production and crystallization at the joint center for structural genomics. Journal of Structural and Functional Genomics. 6: 71-9. PMID 16211502 DOI: 10.1007/S10969-005-2897-2  0.32
2006 Stanfield RL, Wilson IA. Structural studies of human HIV-1 V3 antibodies Human Antibodies. 14: 73-80. DOI: 10.3233/Hab-2005-143-404  0.393
2006 Verdino P, Aldag C, Hilvert D, Wilson IA. Antibodies: specificity and promiscuity of ligand recognition Acta Crystallographica Section a Foundations of Crystallography. 62: s38-s38. DOI: 10.1107/S0108767306099247  0.432
2005 Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. The Journal of Experimental Medicine. 202: 1517-26. PMID 16314439 DOI: 10.1084/Jem.20051625  0.355
2005 Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD. Structural biology: Structure of a V3-containing HIV-1 gp120 core Science. 310: 1025-1028. PMID 16284180 DOI: 10.1126/Science.1118398  0.399
2005 Klock HE, Schwarzenbacher R, Xu Q, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Wilson IA, et al. Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold. Proteins. 61: 1132-6. PMID 16224779 DOI: 10.1002/Prot.20610  0.36
2005 Burton DR, Stanfield RL, Wilson IA. Antibody vs. HIV in a clash of evolutionary titans. Proceedings of the National Academy of Sciences of the United States of America. 102: 14943-8. PMID 16219699 DOI: 10.1073/Pnas.0505126102  0.421
2005 Calarese DA, Lee HK, Huang CY, Best MD, Astronomo RD, Stanfield RL, Katinger H, Burton DR, Wong CH, Wilson IA. Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proceedings of the National Academy of Sciences of the United States of America. 102: 13372-7. PMID 16174734 DOI: 10.1073/Pnas.0505763102  0.821
2005 Jaroszewski L, Schwarzenbacher R, McMullan D, Abdubek P, Agarwalla S, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Wilson IA, et al. Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 A resolution. Proteins. 61: 669-73. PMID 16167343 DOI: 10.1002/Prot.20542  0.331
2005 Luz JG, Yu M, Su Y, Wu Z, Zhou Z, Sun R, Wilson IA. Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A. Journal of Molecular Biology. 352: 1019-28. PMID 16140327 DOI: 10.1016/J.Jmb.2005.08.011  0.373
2005 Rife C, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, ... ... Wilson IA, et al. Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold. Proteins. 61: 444-8. PMID 16104019 DOI: 10.1002/Prot.20468  0.317
2005 Rife C, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, ... ... Wilson IA, et al. Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold. Proteins. 61: 449-53. PMID 16104018 DOI: 10.1002/Prot.20502  0.348
2005 Glaser L, Stevens J, Zamarin D, Wilson IA, García-Sastre A, Tumpey TM, Basler CF, Taubenberger JK, Palese P. A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. Journal of Virology. 79: 11533-6. PMID 16103207 DOI: 10.1128/Jvi.79.17.11533-11536.2005  0.328
2005 Zajonc DM, Cantu C, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nature Immunology. 6: 810-8. PMID 16007091 DOI: 10.1038/Ni1224  0.325
2005 Giabbai B, Sidobre S, Crispin MD, Sanchez-Ruìz Y, Bachi A, Kronenberg M, Wilson IA, Degano M. Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. Journal of Immunology (Baltimore, Md. : 1950). 175: 977-84. PMID 16002697 DOI: 10.4049/Jimmunol.175.2.977  0.372
2005 Han GW, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, ... ... Wilson IA, et al. Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution. Proteins. 60: 797-802. PMID 16001405 DOI: 10.1002/Prot.20467  0.313
2005 Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science (New York, N.Y.). 309: 581-5. PMID 15961631 DOI: 10.1126/Science.1115253  0.788
2005 Van Rhijn I, Zajonc DM, Wilson IA, Moody DB. T-cell activation by lipopeptide antigens. Current Opinion in Immunology. 17: 222-9. PMID 15886110 DOI: 10.1016/J.Coi.2005.04.006  0.307
2005 Moody DB, Zajonc DM, Wilson IA. Anatomy of CD1-lipid antigen complexes. Nature Reviews. Immunology. 5: 387-99. PMID 15864273 DOI: 10.1038/Nri1605  0.36
2005 Wilson IA, Stanfield RL. MHC restriction: slip-sliding away. Nature Immunology. 6: 434-5. PMID 15843798 DOI: 10.1038/Ni0505-434  0.336
2005 Zhang Y, Wang L, Schultz PG, Wilson IA. Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine. Protein Science : a Publication of the Protein Society. 14: 1340-9. PMID 15840835 DOI: 10.1110/Ps.041239305  0.376
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