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Ian A. Wilson, D. Phil., D.Sc. - Publications

Affiliations: 
Molecular Biology Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Structural biology, immunology, X-ray crystallography
Website:
http://www.scripps.edu/mb/wilson/

323 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Adhikary R, Zimmermann J, Stanfield RL, Wilson IA, Yu W, Oda M, Romesberg FE. Structure and Dynamics of Stacking Interactions in an Antibody Binding Site. Biochemistry. PMID 31243995 DOI: 10.1021/acs.biochem.9b00119  1
2019 Yuan M, Cottrell CA, Ozorowski G, van Gils MJ, Kumar S, Wu NC, Sarkar A, Torres JL, de Val N, Copps J, Moore JP, Sanders RW, Ward AB, Wilson IA. Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies. Cell Host & Microbe. 25: 873-883.e5. PMID 31194940 DOI: 10.1016/j.chom.2019.04.011  0.36
2019 Broszeit F, Tzarum N, Zhu X, Nemanichvili N, Eggink D, Leenders T, Li Z, Liu L, Wolfert MA, Papanikolaou A, Martínez-Romero C, Gagarinov IA, Yu W, García-Sastre A, Wennekes T, ... ... Wilson IA, et al. N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses. Cell Reports. 27: 3284-3294.e6. PMID 31189111 DOI: 10.1016/j.celrep.2019.05.048  0.44
2019 Wu NC, Lv H, Thompson AJ, Wu DC, Ng WWS, Kadam RU, Lin CW, Nycholat CM, McBride R, Liang W, Paulson JC, Mok CKP, Wilson IA. Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility. Cell Host & Microbe. PMID 31151913 DOI: 10.1016/j.chom.2019.04.013  0.36
2019 Padayatti PS, Lee SC, Stanfield RL, Wen PC, Tajkhorshid E, Wilson IA, Zhang Q. Structural Insights into the Lipid A Transport Pathway in MsbA. Structure (London, England : 1993). PMID 31130486 DOI: 10.1016/j.str.2019.04.007  1
2019 Andrabi R, Pallesen J, Allen JD, Song G, Zhang J, de Val N, Gegg G, Porter K, Su CY, Pauthner M, Newman A, Bouton-Verville H, Garces F, Wilson IA, Crispin M, et al. The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template. Cell Reports. 27: 2426-2441.e6. PMID 31116986 DOI: 10.1016/j.celrep.2019.04.082  0.52
2019 Bangaru S, Lang S, Schotsaert M, Vanderven HA, Zhu X, Kose N, Bombardi R, Finn JA, Kent SJ, Gilchuk P, Gilchuk I, Turner HL, García-Sastre A, Li S, Ward AB, ... Wilson IA, et al. A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface. Cell. 177: 1136-1152.e18. PMID 31100268 DOI: 10.1016/j.cell.2019.04.011  0.44
2019 Hong S, Shi Y, Wu NC, Grande G, Douthit L, Wang H, Zhou W, Sharpless KB, Wilson IA, Xie J, Wu P. Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification. Nature Communications. 10: 1799. PMID 30996301 DOI: 10.1038/s41467-019-09608-w  0.36
2019 Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, et al. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30971495 DOI: 10.1073/pnas.1817567116  1
2019 Chen F, Tzarum N, Wilson IA, Law M. V1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design. Current Opinion in Virology. 34: 149-159. PMID 30884330 DOI: 10.1016/j.coviro.2019.02.004  0.32
2019 van Dongen MJP, Kadam RU, Juraszek J, Lawson E, Brandenburg B, Schmitz F, Schepens WBG, Stoops B, van Diepen HA, Jongeneelen M, Tang C, Vermond J, van Eijgen-Obregoso Real A, Blokland S, Garg D, ... ... Wilson IA, et al. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science (New York, N.Y.). 363. PMID 30846569 DOI: 10.1126/science.aar6221  0.36
2019 Nguyen DN, Xu B, Stanfield RL, Bailey JK, Horiya S, Temme JS, Leon DR, LaBranche CC, Montefiori DC, Costello CE, Wilson IA, Krauss IJ. Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities. Acs Central Science. 5: 237-249. PMID 30834312 DOI: 10.1021/acscentsci.8b00588  1
2019 Sevy AM, Wu NC, Gilchuk IM, Parrish EH, Burger S, Yousif D, Nagel MBM, Schey KL, Wilson IA, Crowe JE, Meiler J. Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses. Proceedings of the National Academy of Sciences of the United States of America. PMID 30642961 DOI: 10.1073/pnas.1806004116  0.36
2019 Tzarum N, Giang E, Kong L, He L, Prentoe J, Augestad E, Hua Y, Castillo S, Lauer GM, Bukh J, Zhu J, Wilson IA, Law M. Genetic and structural insights into broad neutralization of hepatitis C virus by human V1-69 antibodies. Science Advances. 5: eaav1882. PMID 30613781 DOI: 10.1126/sciadv.aav1882  0.44
2018 Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Abbink P, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, ... ... Wilson IA, et al. Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers. Immunity. PMID 30552025 DOI: 10.1016/j.immuni.2018.11.011  0.52
2018 Zost SJ, Wu NC, Hensley SE, Wilson IA. Immunodominance and antigenic variation of influenza virus hemagglutinin: implications for design of universal vaccine immunogens. The Journal of Infectious Diseases. PMID 30535315 DOI: 10.1093/infdis/jiy696  0.36
2018 He L, Kumar S, Allen JD, Huang D, Lin X, Mann CJ, Saye-Francisco KL, Copps J, Sarkar A, Blizard GS, Ozorowski G, Sok D, Crispin M, Ward AB, Nemazee D, ... ... Wilson IA, et al. HIV-1 vaccine design through minimizing envelope metastability. Science Advances. 4: eaau6769. PMID 30474059 DOI: 10.1126/sciadv.aau6769  0.52
2018 Laursen NS, Friesen RHE, Zhu X, Jongeneelen M, Blokland S, Vermond J, van Eijgen A, Tang C, van Diepen H, Obmolova G, van der Neut Kolfschoten M, Zuijdgeest D, Straetemans R, Hoffman RMB, Nieusma T, ... ... Wilson IA, et al. Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin. Science (New York, N.Y.). 362: 598-602. PMID 30385580 DOI: 10.1126/science.aaq0620  0.44
2018 Credille CV, Dick B, Morrison CN, Stokes RW, Adamek R, Wu NC, Wilson IA, Cohen SM. Structure-Activity Relationships in Metal-Binding Pharmacophores for Influenza Endonuclease. Journal of Medicinal Chemistry. PMID 30351002 DOI: 10.1021/acs.jmedchem.8b01363  0.36
2018 Zhang H, Zhu X, Pascual G, Wadia JS, Keogh E, Hoozemans JJ, Siregar B, Inganäs H, Stoop EJM, Goudsmit J, Apetri A, Koudstaal W, Wilson IA. Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody. Structure (London, England : 1993). PMID 30318466 DOI: 10.1016/j.str.2018.08.012  0.44
2018 Wu NC, Yamayoshi S, Ito M, Uraki R, Kawaoka Y, Wilson IA. Recurring and Adaptable Binding Motifs in Broadly Neutralizing Antibodies to Influenza Virus Are Encoded on the D3-9 Segment of the Ig Gene. Cell Host & Microbe. 24: 569-578.e4. PMID 30308159 DOI: 10.1016/j.chom.2018.09.010  0.36
2018 Yang K, Stanfield RL, Martinez-Yamout MA, Dyson HJ, Wilson IA, Wright PE. Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 30232260 DOI: 10.1073/pnas.1810397115  1
2018 Bianchi M, Turner HL, Nogal B, Cottrell CA, Oyen D, Pauthner M, Bastidas R, Nedellec R, McCoy LE, Wilson IA, Burton DR, Ward AB, Hangartner L. Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization. Immunity. PMID 30097292 DOI: 10.1016/j.immuni.2018.07.009  0.52
2018 Bangaru S, Zhang H, Gilchuk IM, Voss TG, Irving RP, Gilchuk P, Matta P, Zhu X, Lang S, Nieusma T, Richt JA, Albrecht RA, Vanderven HA, Bombardi R, Kent SJ, ... ... Wilson IA, et al. A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nature Communications. 9: 2669. PMID 29991715 DOI: 10.1038/s41467-018-04704-9  0.44
2018 Havenar-Daughton C, Sarkar A, Kulp DW, Toy L, Hu X, Deresa I, Kalyuzhniy O, Kaushik K, Upadhyay AA, Menis S, Landais E, Cao L, Diedrich JK, Kumar S, Schiffner T, ... ... Wilson IA, et al. The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen. Science Translational Medicine. 10. PMID 29973404 DOI: 10.1126/scitranslmed.aat0381  0.36
2018 Aleman F, Tzarum N, Kong L, Nagy K, Zhu J, Wilson IA, Law M. Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. Proceedings of the National Academy of Sciences of the United States of America. PMID 29954862 DOI: 10.1073/pnas.1802378115  0.44
2018 Tzarum N, Wilson IA, Law M. The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein. Frontiers in Immunology. 9: 1315. PMID 29951061 DOI: 10.3389/fimmu.2018.01315  0.32
2018 Rantalainen K, Berndsen ZT, Murrell S, Cao L, Omorodion O, Torres JL, Wu M, Umotoy J, Copps J, Poignard P, Landais E, Paulson JC, Wilson IA, Ward AB. Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Reports. 23: 3249-3261. PMID 29898396 DOI: 10.1016/j.celrep.2018.05.046  0.36
2018 Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, Zhang H, Keogh E, Holland T, Wadia J, Verveen H, Siregar B, Mrosek M, Taggenbrock R, Ameijde J, ... ... Wilson IA, et al. A common antigenic motif recognized by naturally occurring human V5-51/V4-1 anti-tau antibodies with distinct functionalities. Acta Neuropathologica Communications. 6: 43. PMID 29855358 DOI: 10.1186/s40478-018-0543-z  0.44
2018 Guan W, Wu NC, Lee HHY, Li Y, Jiang W, Shen L, Wu DC, Chen R, Zhong N, Wilson IA, Peiris M, Yang Z, Mok CKP. Clinical Correlations of Transcriptional Profile in Patients Infected with Avian Influenza H7N9 Virus. The Journal of Infectious Diseases. PMID 29846612 DOI: 10.1093/infdis/jiy317  0.36
2018 Sarkar A, Bale S, Behrens AJ, Kumar S, Sharma SK, de Val N, Pallesen J, Irimia A, Diwanji DC, Stanfield RL, Ward AB, Crispin M, Wyatt RT, Wilson IA. Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. Nature Communications. 9: 1956. PMID 29769533 DOI: 10.1038/s41467-018-04272-y  1
2018 Kadam RU, Wilson IA. A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin. Proceedings of the National Academy of Sciences of the United States of America. PMID 29610325 DOI: 10.1073/pnas.1801999115  0.36
2018 Gunn RJ, Herrin BR, Acharya S, Cooper MD, Wilson IA. VLR recognition of TLR5 expands the molecular characterization of protein antigen binding by non-Ig-based antibodies. Journal of Molecular Biology. PMID 29596914 DOI: 10.1016/j.jmb.2018.03.016  0.32
2018 Wu NC, Thompson AJ, Xie J, Lin CW, Nycholat CM, Zhu X, Lerner RA, Paulson JC, Wilson IA. A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nature Communications. 9: 1264. PMID 29593268 DOI: 10.1038/s41467-018-03663-5  0.44
2018 Stanfield RL, Haakenson J, Deiss TC, Criscitiello MF, Wilson IA, Smider VV. The Unusual Genetics and Biochemistry of Bovine Immunoglobulins. Advances in Immunology. 137: 135-164. PMID 29455846 DOI: 10.1016/bs.ai.2017.12.004  1
2018 Wu NC, Wilson IA. Structural insights into the design of novel anti-influenza therapies. Nature Structural & Molecular Biology. PMID 29396418 DOI: 10.1038/s41594-018-0025-9  0.36
2018 Voss JE, Andrabi R, McCoy LE, de Val N, Fuller RP, Messmer T, Su CY, Sok D, Khan SN, Garces F, Pritchard LK, Wyatt RT, Ward AB, Crispin M, Wilson IA, et al. Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model. Cell Reports. 22: 1103. PMID 29386130 DOI: 10.1016/j.celrep.2017.10.089  0.52
2017 Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society. PMID 29265822 DOI: 10.1021/jacs.7b08366  0.44
2017 Gopal R, Jackson K, Tzarum N, Kong L, Ettenger A, Guest J, Pfaff JM, Barnes T, Honda A, Giang E, Davidson E, Wilson IA, Doranz BJ, Law M. Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis. Plos Pathogens. 13: e1006735. PMID 29253863 DOI: 10.1371/journal.ppat.1006735  0.44
2017 Landais E, Murrell B, Briney B, Murrell S, Rantalainen K, Berndsen ZT, Ramos A, Wickramasinghe L, Smith ML, Eren K, de Val N, Wu M, Cappelletti A, Umotoy J, Lie Y, ... ... Wilson IA, et al. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity. 47: 990-1003.e9. PMID 29166592 DOI: 10.1016/j.immuni.2017.11.002  0.52
2017 Wu NC, Zost SJ, Thompson AJ, Oyen D, Nycholat CM, McBride R, Paulson JC, Hensley SE, Wilson IA. A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. Plos Pathogens. 13: e1006682. PMID 29059230 DOI: 10.1371/journal.ppat.1006682  0.36
2017 Collins BC, Gunn RJ, McKitrick TR, Cummings RD, Cooper MD, Herrin BR, Wilson IA. Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates. Structure (London, England : 1993). PMID 28988747 DOI: 10.1016/j.str.2017.09.003  0.32
2017 Voss JE, Andrabi R, McCoy LE, de Val N, Fuller RP, Messmer T, Su CY, Sok D, Khan SN, Garces F, Pritchard LK, Wyatt RT, Ward AB, Crispin M, Wilson IA, et al. Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model. Cell Reports. 21: 222-235. PMID 28978475 DOI: 10.1016/j.celrep.2017.09.024  0.52
2017 Kadam RU, Juraszek J, Brandenburg B, Buyck C, Schepens WBG, Kesteleyn B, Stoops B, Vreeken R, Vermond J, Goutier W, Tang C, Vogels R, Friesen RHE, Goudsmit J, van Dongen MJP, ... Wilson IA, et al. Potent peptidic fusion inhibitors of influenza virus. Science (New York, N.Y.). PMID 28971971 DOI: 10.1126/science.aan0516  0.36
2017 Lang S, Xie J, Zhu X, Wu NC, Lerner RA, Wilson IA. Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem. Cell Reports. 20: 2935-2943. PMID 28930686 DOI: 10.1016/j.celrep.2017.08.084  0.44
2017 Medina-Ramírez M, Garces F, Escolano A, Skog P, de Taeye SW, Del Moral-Sanchez I, McGuire AT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof TLGM, Freund NT, Dosenovic P, Hua Y, Gitlin AD, ... ... Wilson IA, et al. Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo. The Journal of Experimental Medicine. PMID 28847869 DOI: 10.1084/jem.20161160  1
2017 Koch K, Kalusche S, Torres JL, Stanfield RL, Danquah W, Khazanehdari K, von Briesen H, Geertsma ER, Wilson IA, Wernery U, Koch-Nolte F, Ward AB, Dietrich U. Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers. Scientific Reports. 7: 8390. PMID 28827559 DOI: 10.1038/s41598-017-08273-7  1
2017 Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA. Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host & Microbe. 22: 247-248. PMID 28799910 DOI: 10.1016/j.chom.2017.07.001  0.36
2017 Oyen D, Fenwick RB, Aoto PC, Stanfield RL, Wilson IA, Dyson HJ, Wright PE. Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase using NMR Relaxation Dispersion. Journal of the American Chemical Society. PMID 28737940 DOI: 10.1021/jacs.7b05958  1
2017 Sok D, Le KM, Vadnais M, Saye-Francisco K, Jardine JG, Torres J, Berndsen ZT, Kong L, Stanfield R, Ruiz J, Ramos A, Liang CH, Chen PL, Criscitiello MF, Mwangi W, ... Wilson IA, et al. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows. Nature. PMID 28726771 DOI: 10.1038/nature23301  0.52
2017 Ozorowski G, Pallesen J, de Val N, Lyumkis D, Cottrell CA, Torres JL, Copps J, Stanfield RL, Cupo A, Pugach P, Moore JP, Wilson IA, Ward AB. Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. Nature. PMID 28700571 DOI: 10.1038/nature23010  1
2017 de Vries RP, Tzarum N, Peng W, Thompson AJ, Ambepitiya Wickramasinghe IN, de la Pena ATT, van Breemen MJ, Bouwman KM, Zhu X, McBride R, Yu W, Sanders RW, Verheije MH, Wilson IA, Paulson JC. A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors. Embo Molecular Medicine. PMID 28694323 DOI: 10.15252/emmm.201707726  0.44
2017 Wright ZVF, Wu NC, Kadam RU, Wilson IA, Wolan DW. Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin. Bioorganic & Medicinal Chemistry Letters. PMID 28689973 DOI: 10.1016/j.bmcl.2017.06.074  0.4
2017 Wu NC, Wilson IA. A perspective on the structural and functional constraints for immune evasion: Insights from the influenza virus. Journal of Molecular Biology. PMID 28648617 DOI: 10.1016/j.jmb.2017.06.015  0.36
2017 Pauthner M, Havenar-Daughton C, Sok D, Nkolola JP, Bastidas R, Boopathy AV, Carnathan DG, Chandrashekar A, Cirelli KM, Cottrell CA, Eroshkin AM, Guenaga J, Kaushik K, Kulp DW, Liu J, ... ... Wilson IA, et al. Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches. Immunity. 46: 1073-1088.e6. PMID 28636956 DOI: 10.1016/j.immuni.2017.05.007  0.52
2017 Park S, Stanfield RL, Martinez-Yamout MA, Dyson HJ, Wilson IA, Wright PE. Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630323 DOI: 10.1073/pnas.1703105114  1
2017 Connelly S, Mortenson DE, Choi S, Wilson IA, Powers ET, Kelly JW, Johnson SM. Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28625364 DOI: 10.1016/j.bmcl.2017.05.080  0.44
2017 Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA. Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host & Microbe. 21: 742-753.e8. PMID 28618270 DOI: 10.1016/j.chom.2017.05.011  0.36
2017 de Vries RP, Peng W, Grant OC, Thompson AJ, Zhu X, Bouwman KM, de la Pena ATT, van Breemen MJ, Ambepitiya Wickramasinghe IN, de Haan CAM, Yu W, McBride R, Sanders RW, Woods RJ, Verheije MH, ... Wilson IA, et al. Three mutations switch H7N9 influenza to human-type receptor specificity. Plos Pathogens. 13: e1006390. PMID 28617868 DOI: 10.1371/journal.ppat.1006390  0.44
2017 Luo X, Fu G, Wang RE, Zhu X, Zambaldo C, Liu R, Liu T, Lyu X, Du J, Xuan W, Yao A, Reed SA, Kang M, Zhang Y, Guo H, ... ... Wilson IA, et al. Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria. Nature Chemical Biology. PMID 28604693 DOI: 10.1038/nchembio.2405  0.44
2017 Guenaga J, Garces F, de Val N, Stanfield RL, Dubrovskaya V, Higgins B, Carrette B, Ward AB, Wilson IA, Wyatt RT. Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein. Immunity. 46: 792-803.e3. PMID 28514686 DOI: 10.1016/j.immuni.2017.04.014  1
2017 Wu NC, Grande G, Turner HL, Ward AB, Xie J, Lerner RA, Wilson IA. In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity. Nature Communications. 8: 15371. PMID 28504265 DOI: 10.1038/ncomms15371  0.36
2017 Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, ... Wilson IA, et al. A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure. Immunity. 46: 690-702. PMID 28423342 DOI: 10.1016/j.immuni.2017.03.017  0.52
2017 Tzarum N, McBride R, Nycholat CM, Paulson JC, Wilson IA. Unique structural features of influenza H15 HA. Journal of Virology. PMID 28404848 DOI: 10.1128/JVI.00046-17  0.36
2017 Tzarum N, de Vries RP, Peng W, Thompson AJ, Bouwman KM, McBride R, Yu W, Zhu X, Verheije MH, Paulson JC, Wilson IA. The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus. Cell Reports. 19: 235-245. PMID 28402848 DOI: 10.1016/j.celrep.2017.03.054  0.44
2017 Pascual G, Wadia JS, Zhu X, Keogh E, Kükrer B, van Ameijde J, Inganäs H, Siregar B, Perdok G, Diefenbach O, Nahar T, Sprengers I, Koldijk MH, der Linden EC, Peferoen LA, ... ... Wilson IA, et al. Immunological memory to hyperphosphorylated tau in asymptomatic individuals. Acta Neuropathologica. PMID 28341999 DOI: 10.1007/s00401-017-1705-y  0.44
2017 Polonskaya Z, Deng S, Sarkar A, Kain L, Comellas-Aragones M, McKay CS, Kaczanowska K, Holt M, McBride R, Palomo V, Self KM, Taylor S, Irimia A, Mehta SR, Dan JM, ... ... Wilson IA, et al. T cells control the generation of nanomolar-affinity anti-glycan antibodies. The Journal of Clinical Investigation. PMID 28287405 DOI: 10.1172/JCI91192  0.36
2017 Irimia A, Serra AM, Sarkar A, Jacak R, Kalyuzhniy O, Sok D, Saye-Francisco KL, Schiffner T, Tingle R, Kubitz M, Adachi Y, Stanfield RL, Deller MC, Burton DR, Schief WR, ... Wilson IA, et al. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design. Plos Pathogens. 13: e1006212. PMID 28225819 DOI: 10.1371/journal.ppat.1006212  1
2016 Stanfield RL, Wilson IA, Smider VV. Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies. Science Immunology. 1: aaf7962. PMID 28783675 DOI: 10.1126/sciimmunol.aaf7962  1
2016 Peng W, de Vries RP, Grant OC, Thompson AJ, McBride R, Tsogtbaatar B, Lee PS, Razi N, Wilson IA, Woods RJ, Paulson JC. Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity. Cell Host & Microbe. PMID 28017661 DOI: 10.1016/j.chom.2016.11.004  0.36
2016 Kadam RU, Wilson IA. Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol. Proceedings of the National Academy of Sciences of the United States of America. PMID 28003465 DOI: 10.1073/pnas.1617020114  0.36
2016 van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, ... ... Wilson IA, et al. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability. Nature Microbiology. 2: 16199. PMID 27841852 DOI: 10.1038/nmicrobiol.2016.199  0.52
2016 Kong L, Lee DE, Kadam RU, Liu T, Giang E, Nieusma T, Garces F, Tzarum N, Woods VL, Ward AB, Li S, Wilson IA, Law M. Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791120 DOI: 10.1073/pnas.1609780113  0.44
2016 Das N, Dewan V, Grace PM, Gunn RJ, Tamura R, Tzarum N, Watkins LR, Wilson IA, Yin H. HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia. Cell Reports. 17: 1128-1140. PMID 27760316 DOI: 10.1016/j.celrep.2016.09.076  0.32
2016 Jardine JG, Sok D, Julien JP, Briney B, Sarkar A, Liang CH, Scherer EM, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, ... ... Wilson IA, et al. Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. Plos Pathogens. 12: e1005905. PMID 27627763 DOI: 10.1371/journal.ppat.1005905  1
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2016 Stanfield RL, Wilson IA, Smider VV. Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies. Science Immunology. 1. PMID 27574710 DOI: 10.1126/sciimmunol.aaf7962  1
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2016 Sok D, Pauthner M, Briney B, Lee JH, Saye-Francisco KL, Hsueh J, Ramos A, Le KM, Jones M, Jardine JG, Bastidas R, Sarkar A, Liang CH, Shivatare SS, Wu CY, ... ... Wilson IA, et al. A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans. Immunity. 45: 31-45. PMID 27438765 DOI: 10.1016/j.immuni.2016.06.026  0.52
2016 He L, de Val N, Morris CD, Vora N, Thinnes TC, Kong L, Azadnia P, Sok D, Zhou B, Burton DR, Wilson IA, Nemazee D, Ward AB, Zhu J. Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles. Nature Communications. 7: 12041. PMID 27349934 DOI: 10.1038/ncomms12041  1
2016 Kong L, He L, de Val N, Vora N, Morris CD, Azadnia P, Sok D, Zhou B, Burton DR, Ward AB, Wilson IA, Zhu J. Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability. Nature Communications. 7: 12040. PMID 27349805 DOI: 10.1038/ncomms12040  1
2016 MacLeod DT, Choi NM, Briney B, Garces F, Ver LS, Landais E, Murrell B, Wrin T, Kilembe W, Liang CH, Ramos A, Bian CB, Wickramasinghe L, Kong L, Eren K, ... ... Wilson IA, et al. Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch. Immunity. 44: 1215-1226. PMID 27192579 DOI: 10.1016/j.immuni.2016.04.016  1
2016 Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/jacs.6b02960  1
2016 Chen W, Kong L, Connelly S, Dendle JM, Liu Y, Wilson IA, Powers ET, Kelly JW. Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chemical Biology. PMID 27128252 DOI: 10.1021/acschembio.5b01035  1
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2016 Xu Q, Shoji M, Shibata S, Naito M, Sato K, Elsliger MA, Grant JC, Axelrod HL, Chiu HJ, Farr CL, Jaroszewski L, Knuth MW, Deacon AM, Godzik A, Lesley SA, ... ... Wilson IA, et al. A Distinct Type of Pilus from the Human Microbiome. Cell. PMID 27062925 DOI: 10.1016/j.cell.2016.03.016  1
2016 Jardine JG, Kulp DW, Havenar-Daughton C, Sarkar A, Briney B, Sok D, Sesterhenn F, Ereño-Orbea J, Kalyuzhniy O, Deresa I, Hu X, Spencer S, Jones M, Georgeson E, Adachi Y, ... ... Wilson IA, et al. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen. Science (New York, N.Y.). 351: 1458-63. PMID 27013733 DOI: 10.1126/science.aad9195  1
2016 Behrens AJ, Vasiljevic S, Pritchard LK, Harvey DJ, Andev RS, Krumm SA, Struwe WB, Cupo A, Kumar A, Zitzmann N, Seabright GE, Kramer HB, Spencer DI, Royle L, Lee JH, ... ... Wilson IA, et al. Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein. Cell Reports. PMID 26972002 DOI: 10.1016/j.celrep.2016.02.058  1
2016 Thornburg NJ, Zhang H, Bangaru S, Sapparapu G, Kose N, Lampley RM, Bombardi RG, Yu Y, Graham S, Branchizio A, Yoder SM, Rock MT, Creech CB, Edwards KM, Lee D, ... ... Wilson IA, et al. H7N9 influenza virus neutralizing antibodies that possess few somatic mutations. The Journal of Clinical Investigation. PMID 26950424 DOI: 10.1172/JCI85317  1
2016 Koday MT, Nelson J, Chevalier A, Koday M, Kalinoski H, Stewart L, Carter L, Nieusma T, Lee PS, Ward AB, Wilson IA, Dagley A, Smee DF, Baker D, Fuller DH. A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response. Plos Pathogens. 12: e1005409. PMID 26845438 DOI: 10.1371/journal.ppat.1005409  1
2016 Irimia A, Sarkar A, Stanfield RL, Wilson IA. Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10. Immunity. 44: 21-31. PMID 26777395 DOI: 10.1016/j.immuni.2015.12.001  1
2015 de Taeye SW, Ozorowski G, Torrents de la Peña A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, ... ... Wilson IA, et al. Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes. Cell. 163: 1702-15. PMID 26687358 DOI: 10.1016/j.cell.2015.11.056  1
2015 Garces F, Lee JH, de Val N, Torrents de la Pena A, Kong L, Puchades C, Hua Y, Stanfield RL, Burton DR, Moore JP, Sanders RW, Ward AB, Wilson IA. Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans. Immunity. 43: 1053-63. PMID 26682982 DOI: 10.1016/j.immuni.2015.11.007  1
2015 Bhowmik S, Chiu HP, Jones DH, Chiu HJ, Miller MD, Xu Q, Farr CL, Ridlon JM, Wells JE, Elsliger MA, Wilson IA, Hylemon PB, Lesley SA. Structure and Functional Characterization of a Bile Acid 7α Dehydratase BaiE in Secondary Bile Acid Synthesis. Proteins. PMID 26650892 DOI: 10.1002/prot.24971  1
2015 Zhu X, Viswanathan K, Raman R, Yu W, Sasisekharan R, Wilson IA. Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants. Cell Reports. PMID 26586437 DOI: 10.1016/j.celrep.2015.10.027  1
2015 Kong L, Torrents de la Peña A, Deller MC, Garces F, Sliepen K, Hua Y, Stanfield RL, Sanders RW, Wilson IA. Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer. Acta Crystallographica. Section D, Biological Crystallography. 71: 2099-108. PMID 26457433 DOI: 10.1107/S1399004715013917  1
2015 Lee JH, Leaman DP, Kim AS, Torrents de la Peña A, Sliepen K, Yasmeen A, Derking R, Ramos A, de Taeye SW, Ozorowski G, Klein F, Burton DR, Nussenzweig MC, Poignard P, Moore JP, ... ... Wilson IA, et al. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nature Communications. 6: 8167. PMID 26404402 DOI: 10.1038/ncomms9167  1
2015 Xu Q, Mengin-Lecreulx D, Liu XW, Patin D, Farr CL, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Godzik A, Lesley SA, Elsliger MA, Deacon AM, Wilson IA. Insights into Substrate Specificity of NlpC/P60 Cell Wall Hydrolases Containing Bacterial SH3 Domains. Mbio. 6. PMID 26374125 DOI: 10.1128/mBio.02327-14  1
2015 Julien JP, Lee JH, Ozorowski G, Hua Y, Torrents de la Peña A, de Taeye SW, Nieusma T, Cupo A, Yasmeen A, Golabek M, Pugach P, Klasse PJ, Moore JP, Sanders RW, Ward AB, ... Wilson IA, et al. Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens. Proceedings of the National Academy of Sciences of the United States of America. PMID 26372963 DOI: 10.1073/pnas.1507793112  1
2015 Ringe RP, Yasmeen A, Ozorowski G, Go EP, Pritchard LK, Guttman M, Ketas TA, Cottrell CA, Wilson IA, Sanders RW, Cupo A, Crispin M, Lee KK, Desaire H, Ward AB, et al. Influences on the design and purification of soluble, recombinant native-like HIV-1 envelope glycoprotein trimers. Journal of Virology. PMID 26311893 DOI: 10.1128/JVI.01768-15  1
2015 Impagliazzo A, Milder F, Kuipers H, Wagner MV, Zhu X, Hoffman RM, van Meersbergen R, Huizingh J, Wanningen P, Verspuij J, de Man M, Ding Z, Apetri A, Kükrer B, Sneekes-Vriese E, ... ... Wilson IA, et al. A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. Science (New York, N.Y.). 349: 1301-6. PMID 26303961 DOI: 10.1126/science.aac7263  1
2015 He L, Cheng Y, Kong L, Azadnia P, Giang E, Kim J, Wood MR, Wilson IA, Law M, Zhu J. Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding. Scientific Reports. 5: 12501. PMID 26238798 DOI: 10.1038/srep12501  1
2015 Kong L, Kadam RU, Giang E, Ruwona TB, Nieusma T, Culhane JC, Stanfield RL, Dawson PE, Wilson IA, Law M. Structure of hepatitis C virus envelope glycoprotein E1 antigenic site 314-324 in complex with antibody IGH526. Journal of Molecular Biology. PMID 26135247 DOI: 10.1016/j.jmb.2015.06.012  1
2015 Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L, Arendt H, Kim HJ, Lee JH, Pugach P, Williams M, ... ... Wilson IA, et al. HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers. Science (New York, N.Y.). 349: aac4223. PMID 26089353 DOI: 10.1126/science.aac4223  1
2015 Pritchard LK, Vasiljevic S, Ozorowski G, Seabright GE, Cupo A, Ringe R, Kim HJ, Sanders RW, Doores KJ, Burton DR, Wilson IA, Ward AB, Moore JP, Crispin M. Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers. Cell Reports. 11: 1604-13. PMID 26051934 DOI: 10.1016/j.celrep.2015.05.017  1
2015 Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW. A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. Journal of the American Chemical Society. 137: 7404-14. PMID 26051248 DOI: 10.1021/jacs.5b03042  1
2015 Willis JR, Sapparapu G, Murrell S, Julien JP, Singh V, King HG, Xia Y, Pickens JA, LaBranche CC, Slaughter JC, Montefiori DC, Wilson IA, Meiler J, Crowe JE. Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth. The Journal of Clinical Investigation. 125: 2523-31. PMID 25985274 DOI: 10.1172/JCI80693  1
2015 Doores KJ, Kong L, Krumm SA, Le KM, Sok D, Laserson U, Garces F, Poignard P, Wilson IA, Burton DR. Correction for Doores et al., Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope. Journal of Virology. 89: 6525. PMID 25979983 DOI: 10.1128/JVI.00593-15  1
2015 Kong L, Jackson KN, Wilson IA, Law M. Capitalizing on knowledge of hepatitis C virus neutralizing epitopes for rational vaccine design. Current Opinion in Virology. 11: 148-157. PMID 25932568 DOI: 10.1016/j.coviro.2015.04.001  1
2015 Lee PS, Zhu X, Yu W, Wilson IA. Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer. Journal of Virology. 89: 7417-20. PMID 25926650 DOI: 10.1128/JVI.00808-15  1
2015 Deller MC, Johnson HA, Miller MD, Spraggon G, Elsliger MA, Wilson IA, Lesley SA. Crystal structure of a two-subunit TrkA octameric gating ring assembly. Plos One. 10: e0122512. PMID 25826626 DOI: 10.1371/journal.pone.0122512  1
2015 Derking R, Ozorowski G, Sliepen K, Yasmeen A, Cupo A, Torres JL, Julien JP, Lee JH, van Montfort T, de Taeye SW, Connors M, Burton DR, Wilson IA, Klasse PJ, Ward AB, et al. Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer. Plos Pathogens. 11: e1004767. PMID 25807248 DOI: 10.1371/journal.ppat.1004767  1
2015 Zhang H, de Vries RP, Tzarum N, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA. A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors. Cell Host & Microbe. 17: 377-84. PMID 25766296 DOI: 10.1016/j.chom.2015.02.006  1
2015 Tzarum N, de Vries RP, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA. Structure and receptor binding of the hemagglutinin from a human H6N1 influenza virus. Cell Host & Microbe. 17: 369-76. PMID 25766295 DOI: 10.1016/j.chom.2015.02.005  1
2015 Adhikary R, Yu W, Oda M, Walker RC, Chen T, Stanfield RL, Wilson IA, Zimmermann J, Romesberg FE. Adaptive mutations alter antibody structure and dynamics during affinity maturation. Biochemistry. 54: 2085-93. PMID 25756188 DOI: 10.1021/bi501417q  1
2015 Lee PS, Arnell AJ, Wilson IA. Structure of the apo anti-influenza CH65 Fab. Acta Crystallographica. Section F, Structural Biology Communications. 71: 145-8. PMID 25664786 DOI: 10.1107/S2053230X14027599  1
2015 Guttman M, Cupo A, Julien JP, Sanders RW, Wilson IA, Moore JP, Lee KK. Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env. Nature Communications. 6: 6144. PMID 25652336 DOI: 10.1038/ncomms7144  1
2015 Ward AB, Wilson IA. Insights into the trimeric HIV-1 envelope glycoprotein structure. Trends in Biochemical Sciences. 40: 101-7. PMID 25600289 DOI: 10.1016/j.tibs.2014.12.006  1
2015 Pugach P, Ozorowski G, Cupo A, Ringe R, Yasmeen A, de Val N, Derking R, Kim HJ, Korzun J, Golabek M, de Los Reyes K, Ketas TJ, Julien JP, Burton DR, Wilson IA, et al. A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene. Journal of Virology. 89: 3380-95. PMID 25589637 DOI: 10.1128/JVI.03473-14  1
2015 Kong L, Wilson IA, Kwong PD. Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262. Proteins. 83: 590-6. PMID 25546301 DOI: 10.1002/prot.24747  1
2015 Lockner JW, Eubanks LM, Choi JL, Lively JM, Schlosburg JE, Collins KC, Globisch D, Rosenfeld-Gunn RJ, Wilson IA, Janda KD. Flagellin as carrier and adjuvant in cocaine vaccine development. Molecular Pharmaceutics. 12: 653-62. PMID 25531528 DOI: 10.1021/mp500520r  0.48
2015 Stanfield RL, De Castro C, Marzaioli AM, Wilson IA, Pantophlet R. Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose. Glycobiology. 25: 412-9. PMID 25380763 DOI: 10.1093/glycob/cwu123  1
2015 Doores KJ, Kong L, Krumm SA, Le KM, Sok D, Laserson U, Garces F, Poignard P, Wilson IA, Burton DR. Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope. Journal of Virology. 89: 1105-18. PMID 25378488 DOI: 10.1128/JVI.02905-14  1
2015 Lee PS, Wilson IA. Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies. Current Topics in Microbiology and Immunology. 386: 323-41. PMID 25037260 DOI: 10.1007/82_2014_413  1
2015 Jiménez-Dalmaroni MJ, Radcliffe CM, Harvey DJ, Wormald MR, Verdino P, Ainge GD, Larsen DS, Painter GF, Ulevitch R, Beutler B, Rudd PM, Dwek RA, Wilson IA. Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunity. 21: 175-93. PMID 24591200 DOI: 10.1177/1753425914524077  1
2014 Stanfield RL, Wilson IA. Antibody Structure. Microbiology Spectrum. 2. PMID 26105818 DOI: 10.1128/microbiolspec.AID-0012-2013  1
2014 Xu Q, Mengin-Lecreulx D, Patin D, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Godzik A, Lesley SA, Elsliger MA, Deacon AM, Wilson IA. Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family. Structure (London, England : 1993). 22: 1799-809. PMID 25465128 DOI: 10.1016/j.str.2014.09.018  1
2014 Sok D, van Gils MJ, Pauthner M, Julien JP, Saye-Francisco KL, Hsueh J, Briney B, Lee JH, Le KM, Lee PS, Hua Y, Seaman MS, Moore JP, Ward AB, Wilson IA, et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. Proceedings of the National Academy of Sciences of the United States of America. 111: 17624-9. PMID 25422458 DOI: 10.1073/pnas.1415789111  1
2014 Bird GH, Irimia A, Ofek G, Kwong PD, Wilson IA, Walensky LD. Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nature Structural & Molecular Biology. 21: 1058-67. PMID 25420104 DOI: 10.1038/nsmb.2922  1
2014 Bowers PM, Verdino P, Wang Z, da Silva Correia J, Chhoa M, Macondray G, Do M, Neben TY, Horlick RA, Stanfield RL, Wilson IA, King DJ. Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. The Journal of Biological Chemistry. 289: 33557-67. PMID 25320089 DOI: 10.1074/jbc.M114.607176  1
2014 Chiu HJ, Grant JC, Farr CL, Jaroszewski L, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA. Structural analysis of arabinose-5-phosphate isomerase from Bacteroides fragilis and functional implications. Acta Crystallographica. Section D, Biological Crystallography. 70: 2640-51. PMID 25286848 DOI: 10.1107/S1399004714017052  1
2014 Garces F, Sok D, Kong L, McBride R, Kim HJ, Saye-Francisco KF, Julien JP, Hua Y, Cupo A, Moore JP, Paulson JC, Ward AB, Burton DR, Wilson IA. Structural evolution of glycan recognition by a family of potent HIV antibodies. Cell. 159: 69-79. PMID 25259921 DOI: 10.1016/j.cell.2014.09.009  1
2014 Tan GS, Lee PS, Hoffman RM, Mazel-Sanchez B, Krammer F, Leon PE, Ward AB, Wilson IA, Palese P. Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin. Journal of Virology. 88: 13580-92. PMID 25210195 DOI: 10.1128/JVI.02289-14  1
2014 Xu Q, Deller MC, Nielsen TK, Grant JC, Lesley SA, Elsliger MA, Deacon AM, Wilson IA. Structural insights into the recognition of phosphopeptide by the FHA domain of kanadaptin. Plos One. 9: e107309. PMID 25197798 DOI: 10.1371/journal.pone.0107309  1
2014 Kumar A, Punta M, Axelrod HL, Das D, Farr CL, Grant JC, Chiu HJ, Miller MD, Coggill PC, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA. Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake. Protein Science : a Publication of the Protein Society. 23: 1380-91. PMID 25044324 DOI: 10.1002/pro.2522  1
2014 Murin CD, Julien JP, Sok D, Stanfield RL, Khayat R, Cupo A, Moore JP, Burton DR, Wilson IA, Ward AB. Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy. Journal of Virology. 88: 10177-88. PMID 24965454 DOI: 10.1128/JVI.01229-14  1
2014 Yasmeen A, Ringe R, Derking R, Cupo A, Julien JP, Burton DR, Ward AB, Wilson IA, Sanders RW, Moore JP, Klasse PJ. Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits. Retrovirology. 11: 41. PMID 24884783 DOI: 10.1186/1742-4690-11-41  0.52
2014 Sok D, Doores KJ, Briney B, Le KM, Saye-Francisco KL, Ramos A, Kulp DW, Julien JP, Menis S, Wickramasinghe L, Seaman MS, Schief WR, Wilson IA, Poignard P, Burton DR. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV. Science Translational Medicine. 6: 236ra63. PMID 24828077 DOI: 10.1126/scitranslmed.3008104  0.52
2014 Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Peña AT, Cupo A, Julien JP, van Gils M, Lee PS, Peng W, Paulson JC, Poignard P, Burton DR, Moore JP, ... ... Wilson IA, et al. Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers. Immunity. 40: 669-80. PMID 24768348 DOI: 10.1016/j.immuni.2014.04.008  0.52
2014 Falkowska E, Le KM, Ramos A, Doores KJ, Lee JH, Blattner C, Ramirez A, Derking R, van Gils MJ, Liang CH, Mcbride R, von Bredow B, Shivatare SS, Wu CY, Chan-Hui PY, ... ... Wilson IA, et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers. Immunity. 40: 657-68. PMID 24768347 DOI: 10.1016/j.immuni.2014.04.009  0.52
2014 Lee PS, Ohshima N, Stanfield RL, Yu W, Iba Y, Okuno Y, Kurosawa Y, Wilson IA. Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus. Nature Communications. 5: 3614. PMID 24717798 DOI: 10.1038/ncomms4614  1
2014 Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, et al. Complement is activated by IgG hexamers assembled at the cell surface. Science (New York, N.Y.). 343: 1260-3. PMID 24626930 DOI: 10.1126/science.1248943  0.52
2014 Tran K, Poulsen C, Guenaga J, de Val N, de Val Alda N, Wilson R, Sundling C, Li Y, Stanfield RL, Wilson IA, Ward AB, Karlsson Hedestam GB, Wyatt RT. Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign. Proceedings of the National Academy of Sciences of the United States of America. 111: E738-47. PMID 24550318 DOI: 10.1073/pnas.1319512111  1
2014 Grover RK, Zhu X, Nieusma T, Jones T, Boero I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, ... ... Wilson IA, et al. A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union. Science (New York, N.Y.). 343: 656-61. PMID 24503852 DOI: 10.1126/science.1246135  0.44
2014 Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC, Throsby M, Kwakkenbos MJ, ... ... Wilson IA, et al. A common solution to group 2 influenza virus neutralization. Proceedings of the National Academy of Sciences of the United States of America. 111: 445-50. PMID 24335589 DOI: 10.1073/pnas.1319058110  0.32
2014 de Vries RP, Zhu X, McBride R, Rigter A, Hanson A, Zhong G, Hatta M, Xu R, Yu W, Kawaoka Y, de Haan CA, Wilson IA, Paulson JC. Hemagglutinin receptor specificity and structural analyses of respiratory droplet-transmissible H5N1 viruses. Journal of Virology. 88: 768-73. PMID 24173215 DOI: 10.1128/JVI.02690-13  0.44
2014 Baranczak A, Connelly S, Liu Y, Choi S, Grimster NP, Powers ET, Wilson IA, Kelly JW. Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn. Biopolymers. 101: 484-95. PMID 24105107 DOI: 10.1002/bip.22407  0.44
2014 Tian F, Lu Y, Manibusan A, Sellers A, Tran H, Sun Y, Phuong T, Barnett R, Hehli B, Song F, DeGuzman MJ, Ensari S, Pinkstaff JK, Sullivan LM, Biroc SL, et al. A single site secured Assay and Drug Development Technologies. 12: 200-201. DOI: 10.1089/adt.2014.1204.lr  0.44
2013 Xu R, de Vries RP, Zhu X, Nycholat CM, McBride R, Yu W, Paulson JC, Wilson IA. Preferential recognition of avian-like receptors in human influenza A H7N9 viruses. Science (New York, N.Y.). 342: 1230-5. PMID 24311689 DOI: 10.1126/science.1243761  0.44
2013 Kong L, Giang E, Nieusma T, Kadam RU, Cogburn KE, Hua Y, Dai X, Stanfield RL, Burton DR, Ward AB, Wilson IA, Law M. Hepatitis C virus E2 envelope glycoprotein core structure. Science (New York, N.Y.). 342: 1090-4. PMID 24288331 DOI: 10.1126/science.1243876  1
2013 Sok D, Laserson U, Laserson J, Liu Y, Vigneault F, Julien JP, Briney B, Ramos A, Saye KF, Le K, Mahan A, Wang S, Kardar M, Yaari G, Walker LM, ... ... Wilson IA, et al. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. Plos Pathogens. 9: e1003754. PMID 24278016 DOI: 10.1371/journal.ppat.1003754  0.52
2013 Suh EH, Liu Y, Connelly S, Genereux JC, Wilson IA, Kelly JW. Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. Journal of the American Chemical Society. 135: 17869-80. PMID 24180271 DOI: 10.1021/ja408230k  0.44
2013 Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science (New York, N.Y.). 342: 1484-90. PMID 24179160 DOI: 10.1126/science.1245627  0.52
2013 Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, Deller MC, Klasse PJ, Burton DR, Sanders RW, Moore JP, Ward AB, Wilson IA. Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science (New York, N.Y.). 342: 1477-83. PMID 24179159 DOI: 10.1126/science.1245625  1
2013 Tong S, Zhu X, Li Y, Shi M, Zhang J, Bourgeois M, Yang H, Chen X, Recuenco S, Gomez J, Chen LM, Johnson A, Tao Y, Dreyfus C, Yu W, ... ... Wilson IA, et al. New world bats harbor diverse influenza A viruses. Plos Pathogens. 9: e1003657. PMID 24130481 DOI: 10.1371/journal.ppat.1003657  0.44
2013 Das D, Hervé M, Elsliger MA, Kadam RU, Grant JC, Chiu HJ, Knuth MW, Klock HE, Miller MD, Godzik A, Lesley SA, Deacon AM, Mengin-Lecreulx D, Wilson IA. Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling. Journal of Bacteriology. 195: 5555-66. PMID 24123814 DOI: 10.1128/JB.00900-13  0.36
2013 Bhabha G, Ekiert DC, Jennewein M, Zmasek CM, Tuttle LM, Kroon G, Dyson HJ, Godzik A, Wilson IA, Wright PE. Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nature Structural & Molecular Biology. 20: 1243-9. PMID 24077226 DOI: 10.1038/nsmb.2676  0.32
2013 Zhu X, Guo YH, Jiang T, Wang YD, Chan KH, Li XF, Yu W, McBride R, Paulson JC, Yuen KY, Qin CF, Che XY, Wilson IA. A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutinin. Journal of Virology. 87: 12619-35. PMID 24049169 DOI: 10.1128/JVI.01577-13  0.44
2013 Hong M, Lee PS, Hoffman RM, Zhu X, Krause JC, Laursen NS, Yoon SI, Song L, Tussey L, Crowe JE, Ward AB, Wilson IA. Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site. Journal of Virology. 87: 12471-80. PMID 24027321 DOI: 10.1128/JVI.01388-13  0.44
2013 Myung N, Connelly S, Kim B, Park SJ, Wilson IA, Kelly JW, Choi S. Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chemical Communications (Cambridge, England). 49: 9188-90. PMID 23989101 DOI: 10.1039/c3cc44667k  0.44
2013 Szent-Gyorgyi C, Stanfield RL, Andreko S, Dempsey A, Ahmed M, Capek S, Waggoner AS, Wilson IA, Bruchez MP. Malachite green mediates homodimerization of antibody VL domains to form a fluorescent ternary complex with singular symmetric interfaces. Journal of Molecular Biology. 425: 4595-613. PMID 23978698 DOI: 10.1016/j.jmb.2013.08.014  1
2013 Connelly S, DeMartino JK, Boger DL, Wilson IA. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase. Biochemistry. 52: 5133-44. PMID 23869564 DOI: 10.1021/bi4005182  0.44
2013 Bale S, Julien JP, Bornholdt ZA, Krois AS, Wilson IA, Saphire EO. Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism. Journal of Virology. 87: 10385-8. PMID 23824825 DOI: 10.1128/JVI.01452-13  0.52
2013 Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7. PMID 23716704 DOI: 10.1073/pnas.1300761110  0.44
2013 Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, ... ... Wilson IA, et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nature Structural & Molecular Biology. 20: 796-803. PMID 23708606 DOI: 10.1038/nsmb.2594  1
2013 Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, ... ... Wilson IA, et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. Plos Pathogens. 9: e1003342. PMID 23658524 DOI: 10.1371/journal.ppat.1003342  1
2013 Jardine J, Julien JP, Menis S, Ota T, Kalyuzhniy O, McGuire A, Sok D, Huang PS, MacPherson S, Jones M, Nieusma T, Mathison J, Baker D, Ward AB, Burton DR, ... ... Wilson IA, et al. Rational HIV immunogen design to target specific germline B cell receptors. Science (New York, N.Y.). 340: 711-6. PMID 23539181 DOI: 10.1126/science.1234150  0.52
2013 Wang F, Sen S, Zhang Y, Ahmad I, Zhu X, Wilson IA, Smider VV, Magliery TJ, Schultz PG. Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation. Proceedings of the National Academy of Sciences of the United States of America. 110: 4261-6. PMID 23440204 DOI: 10.1073/pnas.1301810110  0.44
2013 Xu R, Krause JC, McBride R, Paulson JC, Crowe JE, Wilson IA. A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin. Nature Structural & Molecular Biology. 20: 363-70. PMID 23396351 DOI: 10.1038/nsmb.2500  0.36
2013 Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. Journal of the American Chemical Society. 135: 5656-68. PMID 23350654 DOI: 10.1021/ja311729d  0.44
2013 Zhu X, Yu W, McBride R, Li Y, Chen LM, Donis RO, Tong S, Paulson JC, Wilson IA. Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities. Proceedings of the National Academy of Sciences of the United States of America. 110: 1458-63. PMID 23297216 DOI: 10.1073/pnas.1218509110  0.44
2013 Lee JY, Kim HS, Baek IW, Back JM, Han MR, Kong SY, Kim JH, Kirchdoerfer RN, Kim JO, Cooper MD, Wilson IA, Kim HJ, Han BW. Overexpression, crystallization and preliminary X-ray crystallographic analysis of the variable lymphocyte receptor 2913 ectodomain fused with internalin B. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 39-41. PMID 23295483 DOI: 10.1107/S1744309112045484  0.32
2013 Kong L, Stanfield RL, Wilson IA. Molecular recognition of HIV glycans by antibodies Hiv Glycans in Infection and Immunity. 117-141. DOI: 10.1007/978-1-4614-8872-9_5  1
2012 Moeller A, Kirchdoerfer RN, Potter CS, Carragher B, Wilson IA. Organization of the influenza virus replication machinery. Science (New York, N.Y.). 338: 1631-4. PMID 23180774 DOI: 10.1126/science.1227270  0.32
2012 Burton DR, Ahmed R, Barouch DH, Butera ST, Crotty S, Godzik A, Kaufmann DE, McElrath MJ, Nussenzweig MC, Pulendran B, Scanlan CN, Schief WR, Silvestri G, Streeck H, Walker BD, ... ... Wilson IA, et al. A Blueprint for HIV Vaccine Discovery. Cell Host & Microbe. 12: 396-407. PMID 23084910 DOI: 10.1016/j.chom.2012.09.008  0.52
2012 Bale S, Julien JP, Bornholdt ZA, Kimberlin CR, Halfmann P, Zandonatti MA, Kunert J, Kroon GJ, Kawaoka Y, MacRae IJ, Wilson IA, Saphire EO. Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. Plos Pathogens. 8: e1002916. PMID 23028316 DOI: 10.1371/journal.ppat.1002916  0.52
2012 Zhu X, McBride R, Nycholat CM, Yu W, Paulson JC, Wilson IA. Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors. Journal of Virology. 86: 13371-83. PMID 23015718 DOI: 10.1128/JVI.01426-12  0.44
2012 Zhu X, Yang H, Guo Z, Yu W, Carney PJ, Li Y, Chen LM, Paulson JC, Donis RO, Tong S, Stevens J, Wilson IA. Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site. Proceedings of the National Academy of Sciences of the United States of America. 109: 18903-8. PMID 23012478 DOI: 10.1073/pnas.1212579109  0.44
2012 Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, ... ... Wilson IA, et al. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature. 489: 526-32. PMID 22982990 DOI: 10.1038/nature11414  0.4
2012 Kong L, Giang E, Nieusma T, Robbins JB, Deller MC, Stanfield RL, Wilson IA, Law M. Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412 to 423 in complex with antibody AP33. Journal of Virology. 86: 13085-8. PMID 22973046 DOI: 10.1128/JVI.01939-12  1
2012 Buck-Koehntop BA, Stanfield RL, Ekiert DC, Martinez-Yamout MA, Dyson HJ, Wilson IA, Wright PE. Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proceedings of the National Academy of Sciences of the United States of America. 109: 15229-34. PMID 22949637 DOI: 10.1073/pnas.1213726109  1
2012 Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin Ö, ... ... Wilson IA, et al. Highly conserved protective epitopes on influenza B viruses. Science (New York, N.Y.). 337: 1343-8. PMID 22878502 DOI: 10.1126/science.1222908  0.32
2012 Schünemann K, Connelly S, Kowalczyk R, Sperry J, Wilson IA, Fraser JD, Brimble MA. A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 5018-24. PMID 22763202 DOI: 10.1016/j.bmcl.2012.06.015  0.44
2012 Xu R, Zhu X, McBride R, Nycholat CM, Yu W, Paulson JC, Wilson IA. Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic. Journal of Virology. 86: 9221-32. PMID 22718832 DOI: 10.1128/JVI.00697-12  0.44
2012 Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proceedings of the National Academy of Sciences of the United States of America. 109: 9629-34. PMID 22645360 DOI: 10.1073/pnas.1121005109  0.44
2012 Kong L, Giang E, Robbins JB, Stanfield RL, Burton DR, Wilson IA, Law M. Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1. Proceedings of the National Academy of Sciences of the United States of America. 109: 9499-504. PMID 22623528 DOI: 10.1073/pnas.1202924109  1
2012 Nycholat CM, McBride R, Ekiert DC, Xu R, Rangarajan J, Peng W, Razi N, Gilbert M, Wakarchuk W, Wilson IA, Paulson JC. Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza A virus hemagglutinins. Angewandte Chemie (International Ed. in English). 51: 4860-3. PMID 22505324 DOI: 10.1002/anie.201200596  0.36
2012 Kirchdoerfer RN, Herrin BR, Han BW, Turnbough CL, Cooper MD, Wilson IA. Variable lymphocyte receptor recognition of the immunodominant glycoprotein of Bacillus anthracis spores. Structure (London, England : 1993). 20: 479-86. PMID 22405006 DOI: 10.1016/j.str.2012.01.009  0.32
2012 Senutovitch N, Stanfield RL, Bhattacharyya S, Rule GS, Wilson IA, Armitage BA, Waggoner AS, Berget PB. A variable light domain fluorogen activating protein homodimerizes to activate dimethylindole red. Biochemistry. 51: 2471-85. PMID 22390683 DOI: 10.1021/bi201422g  1
2012 Fernandes RA, Shore DA, Vuong MT, Yu C, Zhu X, Pereira-Lopes S, Brouwer H, Fennelly JA, Jessup CM, Evans EJ, Wilson IA, Davis SJ. T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements. The Journal of Biological Chemistry. 287: 13324-35. PMID 22262845 DOI: 10.1074/jbc.M111.332783  0.44
2012 Xu R, McBride R, Nycholat CM, Paulson JC, Wilson IA. Structural characterization of the hemagglutinin receptor specificity from the 2009 H1N1 influenza pandemic. Journal of Virology. 86: 982-90. PMID 22072785 DOI: 10.1128/JVI.06322-11  0.36
2012 Burton DR, Poignard P, Stanfield RL, Wilson IA. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses Science. 337: 183-186. DOI: 10.1126/science.1225416  1
2012 Kong L, Julien JP, Calarese D, Scanlan C, Lee HK, Rudd P, Wong CH, Dwek RA, Burton DR, Wilson IA. Toward a carbohydrate-based HIV-1 vaccine Acs Symposium Series. 1102: 187-215. DOI: 10.1021/bk-2012-1102.ch007  1
2011 Walker LM, Sok D, Nishimura Y, Donau O, Sadjadpour R, Gautam R, Shingai M, Pejchal R, Ramos A, Simek MD, Geng Y, Wilson IA, Poignard P, Martin MA, Burton DR. Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque. Proceedings of the National Academy of Sciences of the United States of America. 108: 20125-9. PMID 22123961 DOI: 10.1073/pnas.1117531108  0.52
2011 McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, ... ... Wilson IA, et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 480: 336-43. PMID 22113616 DOI: 10.1038/nature10696  0.52
2011 Stanfield RL, Julien JP, Pejchal R, Gach JS, Zwick MB, Wilson IA. Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope. Journal of Molecular Biology. 414: 460-76. PMID 22033480 DOI: 10.1016/j.jmb.2011.10.014  1
2011 Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, ... ... Wilson IA, et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science (New York, N.Y.). 334: 1097-103. PMID 21998254 DOI: 10.1126/science.1213256  1
2011 Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Science Translational Medicine. 3: 97ra81. PMID 21865539 DOI: 10.1126/scitranslmed.3002473  0.44
2011 Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Ramos A, Chan-Hui PY, Moyle M, Mitcham JL, Hammond PW, Olsen OA, Phung P, Fling S, ... ... Wilson IA, et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature. 477: 466-70. PMID 21849977 DOI: 10.1038/nature10373  0.52
2011 Ekiert DC, Friesen RH, Bhabha G, Kwaks T, Jongeneelen M, Yu W, Ophorst C, Cox F, Korse HJ, Brandenburg B, Vogels R, Brakenhoff JP, Kompier R, Koldijk MH, Cornelissen LA, ... ... Wilson IA, et al. A highly conserved neutralizing epitope on group 2 influenza A viruses. Science (New York, N.Y.). 333: 843-50. PMID 21737702 DOI: 10.1126/science.1204839  0.32
2011 Bhabha G, Lee J, Ekiert DC, Gam J, Wilson IA, Dyson HJ, Benkovic SJ, Wright PE. A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. Science (New York, N.Y.). 332: 234-8. PMID 21474759 DOI: 10.1126/science.1198542  0.32
2011 Kirchdoerfer RN, Garner AL, Flack CE, Mee JM, Horswill AR, Janda KD, Kaufmann GF, Wilson IA. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. The Journal of Biological Chemistry. 286: 17351-8. PMID 21454495 DOI: 10.1074/jbc.M111.231258  0.48
2011 Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B, Klaus JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P, Buchmeier MJ. A structural analysis of M protein in coronavirus assembly and morphology. Journal of Structural Biology. 174: 11-22. PMID 21130884 DOI: 10.1016/j.jsb.2010.11.021  0.44
2010 Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An αß T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 1996. 274: 209-219. Journal of Immunology (Baltimore, Md. : 1950). 185: 6402-12. PMID 21084669  1
2010 Han GW, Elsliger MA, Yeates TO, Xu Q, Murzin AG, Krishna SS, Jaroszewski L, Abdubek P, Astakhova T, Axelrod HL, Carlton D, Chen C, Chiu HJ, Clayton T, Das D, ... ... Wilson IA, et al. Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1237-44. PMID 20944217 DOI: 10.1107/S1744309110025534  0.32
2010 Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex Journal of Immunology. 185: 209-219. DOI: 10.1126/science.274.5285.209  1
2010 Stauber DJ, Yu M, Wilson IA. Erythropoietin receptor as a paradigm for cytokine signaling Handbook of Cell Signaling, 2/E. 1: 245-252. DOI: 10.1016/B978-0-12-374145-5.00037-1  0.48
2010 Rudolph MG, Stanfield RL, Wilson IA. T cell receptor/pmhc complexes Handbook of Cell Signaling, 2/E. 1: 55-62. DOI: 10.1016/B978-0-12-374145-5.00009-7  1
2010 Stanfield RL, Wilson IA. Antibody-Antigen recognition and conformational changes Handbook of Cell Signaling, 2/E. 1: 29-36. DOI: 10.1016/B978-0-12-374145-5.00005-X  1
2009 Debler EW, Müller R, Hilvert D, Wilson IA. An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket. Proceedings of the National Academy of Sciences of the United States of America. 106: 18539-44. PMID 19846764 DOI: 10.1073/pnas.0902700106  0.8
2009 Haukkala J, Laitinen I, Luoto P, Iveson P, Wilson I, Karlsen H, Cuthbertson A, Laine J, Leppänen P, Ylä-Herttula S, Knuuti J, Roivainen A. 68Ga-DOTA-RGD peptide: Biodistribution and binding into atherosclerotic plaques in mice European Journal of Nuclear Medicine and Molecular Imaging. 36: 2058-2067. PMID 19629477 DOI: 10.1007/s00259-009-1220-z  1
2009 Kwong PD, Wilson IA. HIV-1 and influenza antibodies: Seeing antigens in new ways Nature Immunology. 10: 573-578. PMID 19448659 DOI: 10.1038/ni.1746  1
2009 Zheng M, Cooper DR, Grossoehme NE, Yu M, Hung LW, Cieslik M, Derewenda U, Lesley SA, Wilson IA, Giedroc DP, Derewenda ZS. Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains. Acta Crystallographica. Section D, Biological Crystallography. 65: 356-65. PMID 19307717 DOI: 10.1107/S0907444909004727  1
2009 Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. Antibody recognition of a highly conserved influenza virus epitope. Science (New York, N.Y.). 324: 246-51. PMID 19251591 DOI: 10.1126/science.1171491  1
2009 Schwede T, Sali A, Honig B, Levitt M, Berman HM, Jones D, Brenner SE, Burley SK, Das R, Dokholyan NV, Dunbrack RL, Fidelis K, Fiser A, Godzik A, Huang YJ, ... ... Wilson IA, et al. Outcome of a workshop on applications of protein models in biomedical research. Structure (London, England : 1993). 17: 151-9. PMID 19217386 DOI: 10.1016/j.str.2008.12.014  1
2009 Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. Journal of Medicinal Chemistry. 52: 1115-25. PMID 19191553 DOI: 10.1021/jm801347s  1
2009 Xu Q, Rife CL, Carlton D, Miller MD, Krishna SS, Elsliger MA, Abdubek P, Astakhova T, Chiu HJ, Clayton T, Duan L, Feuerhelm J, Grzechnik SK, Hale J, Han GW, ... ... Wilson IA, et al. Crystal structure of a novel archaeal AAA+ ATPase SSO1545 from Sulfolobus solfataricus. Proteins. 74: 1041-9. PMID 19089981 DOI: 10.1002/prot.22325  1
2009 Wang W, Fridman A, Blackledge W, Connely S, Wilson IA, Pilz R, Boss GR. The phosphatidylinositol 3-kinase/Akt cassette regulates purine nucleotide synthesis Journal of Biological Chemistry. 284: 3521-3528. PMID 19068483 DOI: 10.1074/jbc.M806707200  1
2009 Xu Q, McMullan D, Abdubek P, Astakhova T, Carlton D, Chen C, Chiu HJ, Clayton T, Das D, Deller MC, Duan L, Elsliger MA, Feuerhelm J, Hale J, Han GW, ... ... Wilson IA, et al. A structural basis for the regulatory inactivation of DnaA. Journal of Molecular Biology. 385: 368-80. PMID 19000695 DOI: 10.1016/j.jmb.2008.10.059  1
2009 Laitinen I, Marjamäki P, Någren K, Laine VJO, Wilson I, Leppänen P, Ylä-Herttuala S, Roivainen A, Knuuti J. Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques European Journal of Nuclear Medicine and Molecular Imaging. 36: 73-80. PMID 18712383 DOI: 10.1007/s00259-008-0919-6  1
2008 Zajonc DM, Striegl H, Dascher CC, Wilson IA. The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1 Proceedings of the National Academy of Sciences of the United States of America. 105: 17925-17930. PMID 19004781 DOI: 10.1073/pnas.0809814105  1
2008 Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure (London, England : 1993). 16: 1659-67. PMID 19000818 DOI: 10.1016/j.str.2008.08.018  1
2008 Shore DA, Issafras H, Landais E, Teyton L, Wilson IA. The Crystal Structure of CD8 in Complex with YTS156.7.7 Fab and Interaction with Other CD8 Antibodies Define the Binding Mode of CD8 αβ to MHC Class I Journal of Molecular Biology. 384: 1190-1202. PMID 18929574 DOI: 10.1016/j.jmb.2008.09.069  1
2008 Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science (New York, N.Y.). 321: 1834-7. PMID 18818359 DOI: 10.1126/science.1162484  1
2008 Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. Journal of Medicinal Chemistry. 51: 6348-58. PMID 18811132 DOI: 10.1021/jm800435s  1
2008 Yu X, Tsibane T, McGraw PA, House FS, Keefer CJ, Hicar MD, Tumpey TM, Pappas C, Perrone LA, Martinez O, Stevens J, Wilson IA, Aguilar PV, Altschuler EL, Basler CF, et al. Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. Nature. 455: 532-6. PMID 18716625 DOI: 10.1038/nature07231  1
2008 Xu X, Zhu X, Dwek RA, Stevens J, Wilson IA. Structural characterization of the 1918 influenza virus H1N1 neuraminidase. Journal of Virology. 82: 10493-501. PMID 18715929 DOI: 10.1128/JVI.00959-08  1
2008 Verdino P, Aldag C, Hilvert D, Wilson IA. Closely related antibody receptors exploit fundamentally different strategies for steroid recognition Proceedings of the National Academy of Sciences of the United States of America. 105: 11725-11730. PMID 18689687 DOI: 10.1073/pnas.0801783105  1
2008 DeMartino JK, Hwang I, Connelly S, Wilson IA, Boger DL. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. Journal of Medicinal Chemistry. 51: 5441-8. PMID 18686942 DOI: 10.1021/jm800555h  1
2008 Stevens J, Blixt O, Chen LM, Donis RO, Paulson JC, Wilson IA. Recent Avian H5N1 Viruses Exhibit Increased Propensity for Acquiring Human Receptor Specificity Journal of Molecular Biology. 381: 1382-1394. PMID 18672252 DOI: 10.1016/j.jmb.2008.04.016  1
2008 Zhu X, Xu X, Wilson IA. Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects Acta Crystallographica Section D: Biological Crystallography. 64: 843-850. PMID 18645233 DOI: 10.1107/S0907444908016648  1
2008 Dhillon AK, Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA. Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set Acta Crystallographica Section D: Biological Crystallography. 64: 792-802. PMID 18566514 DOI: 10.1107/S0907444908013978  1
2008 Relloso M, Cheng TY, Im JS, Parisini E, Roura-Mir C, DeBono C, Zajonc DM, Murga LF, Ondrechen MJ, Wilson IA, Porcelli SA, Moody DB. pH-dependent interdomain tethers of CD1b regulate its antigen capture. Immunity. 28: 774-86. PMID 18538591 DOI: 10.1016/j.immuni.2008.04.017  1
2008 Astronomo RD, Lee HK, Scanlan CN, Pantophlet R, Huang CY, Wilson IA, Blixt O, Dwek RA, Wong CH, Burton DR. A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120. Journal of Virology. 82: 6359-68. PMID 18434393 DOI: 10.1128/JVI.00293-08  1
2008 Wei CJ, Xu L, Kong WP, Shi W, Canis K, Stevens J, Yang ZY, Dell A, Haslam SM, Wilson IA, Nabel GJ. Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus. Journal of Virology. 82: 6200-8. PMID 18417563 DOI: 10.1128/JVI.00187-08  1
2008 Debler EW, Müller R, Hilvert D, Wilson IA. Conformational isomerism can limit antibody catalysis. The Journal of Biological Chemistry. 283: 16554-60. PMID 18417480 DOI: 10.1074/jbc.M710256200  1
2008 Kozbial P, Xu Q, Chiu HJ, McMullan D, Krishna SS, Miller MD, Abdubek P, Acosta C, Astakhova T, Axelrod HL, Carlton D, Clayton T, Deller M, Duan L, Elias Y, ... ... Wilson IA, et al. Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold. Proteins. 71: 1589-96. PMID 18324683 DOI: 10.1002/prot.22020  1
2008 Debler EW, Kaufmann GF, Meijler MM, Heine A, Mee JM, Pljevaljcic G, Di Bilio AJ, Schultz PG, Millar DP, Janda KD, Wilson IA, Gray HB, Lerner RA. Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (New York, N.Y.). 319: 1232-5. PMID 18309081 DOI: 10.1126/science.1153445  1
2008 Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L. Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids Journal of Molecular Biology. 377: 1104-1116. PMID 18295796 DOI: 10.1016/j.jmb.2008.01.061  1
2008 Xu Q, Kozbial P, McMullan D, Krishna SS, Brittain SM, Ficarro SB, DiDonato M, Miller MD, Abdubek P, Axelrod HL, Chiu HJ, Clayton T, Duan L, Elsliger MA, Feuerhelm J, ... ... Wilson IA, et al. Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution. Proteins. 71: 1546-52. PMID 18275082 DOI: 10.1002/prot.21992  1
2008 Axelrod HL, McMullan D, Krishna SS, Miller MD, Elsliger MA, Abdubek P, Ambing E, Astakhova T, Carlton D, Chiu HJ, Clayton T, Duan L, Feuerhelm J, Grzechnik SK, Hale J, ... ... Wilson IA, et al. Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution. Proteins. 71: 1042-9. PMID 18260100 DOI: 10.1002/prot.21967  1
2008 Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, ... ... Wilson IA, et al. Protein production and purification. Nature Methods. 5: 135-46. PMID 18235434 DOI: 10.1038/nmeth.f.202  1
2008 Menendez A, Calarese DA, Stanfield RL, Chow KC, Scanlan CN, Kunert R, Katinger H, Burton DR, Wilson IA, Scott JK. A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1380-92. PMID 18198210 DOI: 10.1096/fj.07-8983com  1
2008 Burley SK, Joachimiak A, Montelione GT, Wilson IA. Contributions to the NIH-NIGMS Protein Structure Initiative from the PSI Production Centers Structure. 16: 5-11. PMID 18184575 DOI: 10.1016/j.str.2007.12.002  1
2008 Johnson SM, Connelly S, Wilson IA, Kelly JW. Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. Journal of Medicinal Chemistry. 51: 260-70. PMID 18095641 DOI: 10.1021/jm0708735  1
2007 Slabinski L, Jaroszewski L, Rodrigues APC, Rychlewski L, Wilson IA, Lesley SA, Godzik A. The challenge of protein structure determination - Lessons from structural genomics Protein Science. 16: 2472-2482. PMID 17962404 DOI: 10.1110/ps.073037907  1
2007 Slabinski L, Jaroszewski L, Rychlewski L, Wilson IA, Lesley SA, Godzik A. XtalPred: A web server for prediction of protein crystallizability Bioinformatics. 23: 3403-3405. PMID 17921170 DOI: 10.1093/bioinformatics/btm477  1
2007 Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD. Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science (New York, N.Y.). 317: 1930-4. PMID 17901336 DOI: 10.1126/science.1145373  1
2007 Burton DR, Wilson IA. Immunology: Square-dancing antibodies Science. 317: 1507-1508. PMID 17872431 DOI: 10.1126/science.1148905  1
2007 Stoll R, Lee BM, Debler EW, Laity JH, Wilson IA, Dyson HJ, Wright PE. Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA. Journal of Molecular Biology. 372: 1227-45. PMID 17716689 DOI: 10.1016/j.jmb.2007.07.017  1
2007 Huang S, Romanchuk G, Pattridge K, Lesley SA, Wilson IA, Matthews RG, Ludwig M. Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269. Protein Science : a Publication of the Protein Society. 16: 1588-95. PMID 17656578 DOI: 10.1110/ps.072936307  1
2007 Krishna SS, Tautz L, Xu Q, McMullan D, Miller MD, Abdubek P, Ambing E, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, DiDonato M, Duan L, Elsliger MA, ... ... Wilson IA, et al. Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 angstroms resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases. Proteins. 69: 415-21. PMID 17636569 DOI: 10.1002/prot.21314  1
2007 Zajonc DM, Wilson IA. Architecture of CD1 proteins Current Topics in Microbiology and Immunology. 314: 27-50. PMID 17593656 DOI: 10.1007/978-3-540-69511-0-2  1
2007 Zubieta C, Krishna SS, McMullan D, Miller MD, Abdubek P, Agarwalla S, Ambing E, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, Deller M, DiDonato M, Duan L, ... ... Wilson IA, et al. Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 A resolution. Proteins. 68: 999-1005. PMID 17546672 DOI: 10.1002/prot.21208  1
2007 Sanguineti S, Centeno Crowley JM, Lodeiro Merlo MF, Cerutti ML, Wilson IA, Goldbaum FA, Stanfield RL, de Prat-Gay G. Specific Recognition of a DNA Immunogen by its Elicited Antibody Journal of Molecular Biology. 370: 183-195. PMID 17512945 DOI: 10.1016/j.jmb.2007.04.046  1
2007 Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies. Journal of Molecular Biology. 369: 696-709. PMID 17445828 DOI: 10.1016/j.jmb.2007.01.060  0.52
2007 Debler EW, Kaufmann GF, Kirchdoerfer RN, Mee JM, Janda KD, Wilson IA. Crystal structures of a quorum-quenching antibody. Journal of Molecular Biology. 368: 1392-402. PMID 17400249 DOI: 10.1016/j.jmb.2007.02.081  1
2007 Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. The Journal of Biological Chemistry. 282: 13033-46. PMID 17324932 DOI: 10.1074/jbc.M607293200  1
2007 Müller R, Debler EW, Steinmann M, Seebeck FP, Wilson IA, Hilvert D. Bifunctional catalysis of proton transfer at an antibody active site. Journal of the American Chemical Society. 129: 460-1. PMID 17226987 DOI: 10.1021/ja066578b  1
2007 Frank RA, Långström B, Antoni G, Montalto MC, Agdeppa ED, Mendizabal M, Wilson IA, Vanderheyden JL. The imaging continuum: Bench to biomarkers to diagnostics Journal of Labelled Compounds and Radiopharmaceuticals. 50: 746-769. DOI: 10.1002/jlcr.1444  1
2006 Tian F, Debler EW, Millar DP, Deniz AA, Wilson IA, Schultz PG. The effects of antibodies on stilbene excited-state energetics. Angewandte Chemie (International Ed. in English). 45: 7763-5. PMID 17089439 DOI: 10.1002/anie.200602720  1
2006 Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Molecular Pharmacology. 70: 1885-91. PMID 16968810 DOI: 10.1124/mol.106.025999  1
2006 Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proceedings of the National Academy of Sciences of the United States of America. 103: 2788-93. PMID 16477002 DOI: 10.1073/pnas.0511161103  1
2005 Calarese DA, Lee HK, Huang CY, Best MD, Astronomo RD, Stanfield RL, Katinger H, Burton DR, Wong CH, Wilson IA. Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proceedings of the National Academy of Sciences of the United States of America. 102: 13372-7. PMID 16174734 DOI: 10.1073/pnas.0505763102  1
2005 Choe J, Kelker MS, Wilson IA. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. Science (New York, N.Y.). 309: 581-5. PMID 15961631 DOI: 10.1126/science.1115253  1
2005 Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW. Kinetic stabilization of an oligomeric protein by a single ligand binding event. Journal of the American Chemical Society. 127: 5540-51. PMID 15826192 DOI: 10.1021/ja042929f  1
2005 Debler EW, Ito S, Seebeck FP, Heine A, Hilvert D, Wilson IA. Structural origins of efficient proton abstraction from carbon by a catalytic antibody. Proceedings of the National Academy of Sciences of the United States of America. 102: 4984-9. PMID 15788533 DOI: 10.1073/pnas.0409207102  1
2005 Foss TR, Kelker MS, Wiseman RL, Wilson IA, Kelly JW. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. Journal of Molecular Biology. 347: 841-54. PMID 15769474 DOI: 10.1016/j.jmb.2005.01.050  1
2004 Li C, Xu L, Wolan DW, Wilson IA, Olson AJ. Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors. Journal of Medicinal Chemistry. 47: 6681-90. PMID 15615517 DOI: 10.1021/jm049504o  1
2004 Kelker MS, Debler EW, Wilson IA. Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A. Journal of Molecular Biology. 344: 1175-81. PMID 15561137 DOI: 10.1016/j.jmb.2004.10.009  1
2004 Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wüthrich K, Wilson IA. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. Journal of Molecular Biology. 342: 1237-48. PMID 15351648 DOI: 10.1016/j.jmb.2004.07.089  1
2004 Bryan MC, Fazio F, Lee HK, Huang CY, Chang A, Best MD, Calarese DA, Blixt O, Paulson JC, Burton D, Wilson IA, Wong CH. Covalent display of oligosaccharide arrays in microtiter plates. Journal of the American Chemical Society. 126: 8640-1. PMID 15250702 DOI: 10.1021/ja048433f  1
2004 Larsen NA, de Prada P, Deng SX, Mittal A, Braskett M, Zhu X, Wilson IA, Landry DW. Crystallographic and biochemical analysis of cocaine-degrading antibody 15A10. Biochemistry. 43: 8067-76. PMID 15209502 DOI: 10.1021/bi049495l  1
2004 Lee HK, Scanlan CN, Huang CY, Chang AY, Calarese DA, Dwek RA, Rudd PM, Burton DR, Wilson IA, Wong CH. Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody. Angewandte Chemie (International Ed. in English). 43: 1000-3. PMID 14966891 DOI: 10.1002/anie.200353105  1
2004 Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. The Journal of Biological Chemistry. 279: 18034-45. PMID 14966129 DOI: 10.1074/jbc.M313691200  1
2004 Wolan DW, Cheong CG, Greasley SE, Wilson IA. Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. Biochemistry. 43: 1171-83. PMID 14756553 DOI: 10.1021/bi030162i  1
2003 Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Calarese D, Stanfield R, Wilson IA, Katinger H, Dwek RA, Burton DR, Rudd PM. The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12. Advances in Experimental Medicine and Biology. 535: 205-18. PMID 14714897  1
2003 Saphire EO, Stanfield RL, Crispin MD, Morris G, Zwick MB, Pantophlet RA, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA. Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design. Advances in Experimental Medicine and Biology. 535: 55-66. PMID 14714888  1
2003 Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Biochemistry. 42: 10904-14. PMID 12974624 DOI: 10.1021/bi030106h  1
2003 Calarese DA, Scanlan CN, Zwick MB, Deechongkit S, Mimura Y, Kunert R, Zhu P, Wormald MR, Stanfield RL, Roux KH, Kelly JW, Rudd PM, Dwek RA, Katinger H, Burton DR, ... Wilson IA, et al. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science (New York, N.Y.). 300: 2065-71. PMID 12829775 DOI: 10.1126/science.1083182  1
2003 Zwick MB, Parren PW, Saphire EO, Church S, Wang M, Scott JK, Dawson PE, Wilson IA, Burton DR. Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. Journal of Virology. 77: 5863-76. PMID 12719580 DOI: 10.1128/JVI.77.10.5863-5876.2003  1
2003 Redwan el-RM, Larsen NA, Zhou B, Wirsching P, Janda KD, Wilson IA. Expression and characterization of a humanized cocaine-binding antibody. Biotechnology and Bioengineering. 82: 612-8. PMID 12652485 DOI: 10.1002/bit.10598  1
2003 Rudolph MG, Kelker MS, Schneider TR, Yeates TO, Oseroff V, Heidary DK, Jennings PA, Wilson IA. Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta. Acta Crystallographica. Section D, Biological Crystallography. 59: 290-8. PMID 12554939 DOI: 10.1107/S0907444902021704  1
2003 Zhu X, Larsen NA, Basran A, Bruce NC, Wilson IA. Observation of an arsenic adduct in an acetyl esterase crystal structure. The Journal of Biological Chemistry. 278: 2008-14. PMID 12421810 DOI: 10.1074/jbc.M210103200  1
2002 Wolan DW, Greasley SE, Beardsley GP, Wilson IA. Structural insights into the avian AICAR transformylase mechanism. Biochemistry. 41: 15505-13. PMID 12501179 DOI: 10.1021/bi020505x  1
2002 Larsen NA, Heine A, de Prada P, Redwan el-R, Yeates TO, Landry DW, Wilson IA. Structure determination of a cocaine hydrolytic antibody from a pseudomerohedrally twinned crystal. Acta Crystallographica. Section D, Biological Crystallography. 58: 2055-9. PMID 12454464 DOI: 10.1107/S0907444902017420  1
2002 Turner JM, Larsen NA, Basran A, Barbas CF, Bruce NC, Wilson IA, Lerner RA. Biochemical characterization and structural analysis of a highly proficient cocaine esterase. Biochemistry. 41: 12297-307. PMID 12369817 DOI: 10.1021/bi026131p  1
2002 Saphire EO, Stanfield RL, Crispin MD, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA. Contrasting IgG structures reveal extreme asymmetry and flexibility. Journal of Molecular Biology. 319: 9-18. PMID 12051932 DOI: 10.1016/S0022-2836(02)00244-9  1
2002 Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nature Structural Biology. 9: 17-21. PMID 11742345 DOI: 10.1038/nsb742  1
2001 Larsen NA, Heine A, Crane L, Cravatt BF, Lerner RA, Wilson IA. Structural basis for a disfavored elimination reaction in catalytic antibody 1D4. Journal of Molecular Biology. 314: 93-102. PMID 11724535 DOI: 10.1006/jmbi.2001.5112  0.36
2001 Wentworth P, Jones LH, Wentworth AD, Zhu X, Larsen NA, Wilson IA, Xu X, Goddard WA, Janda KD, Eschenmoser A, Lerner RA. Antibody catalysis of the oxidation of water. Science (New York, N.Y.). 293: 1806-11. PMID 11546867 DOI: 10.1126/science.1062722  1
2001 Saphire EO, Parren PW, Pantophlet R, Zwick MB, Morris GM, Rudd PM, Dwek RA, Stanfield RL, Burton DR, Wilson IA. Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science (New York, N.Y.). 293: 1155-9. PMID 11498595 DOI: 10.1126/science.1061692  1
2001 Larsen NA, Zhou B, Heine A, Wirsching P, Janda KD, Wilson IA. Crystal structure of a cocaine-binding antibody. Journal of Molecular Biology. 311: 9-15. PMID 11469854 DOI: 10.1006/jmbi.2001.4839  1
2001 Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA. Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A. Nature Immunology. 2: 248-54. PMID 11224525 DOI: 10.1038/85311  1
2001 Saphire EO, Parren PW, Barbas CF, Burton DR, Wilson IA. Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1. Acta Crystallographica. Section D, Biological Crystallography. 57: 168-71. PMID 11134947 DOI: 10.1107/S0907444900017376  1
2000 Karlstrom A, Zhong G, Rader C, Larsen NA, Heine A, Fuller R, List B, Tanaka F, Wilson IA, Barbas CF, Lerner RA. Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task. Proceedings of the National Academy of Sciences of the United States of America. 97: 3878-83. PMID 10760259 DOI: 10.1073/pnas.97.8.3878  1
1995 Fremont DH, Stura EA, Matsumura M, Peterson PA, Wilson IA. Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove Proceedings of the National Academy of Sciences of the United States of America. 92: 2479-2483. PMID 7708669 DOI: 10.1073/pnas.92.7.2479  1
1994 Wilson IA, Stanfield RL, Jewell DA, Ghiara JB, Fremont DH, Stura EA. Immune recognition of viral antigens Infectious Agents and Disease. 3: 155-162. PMID 7812653  1
1993 Wilson IA, Fremont DH. Structural analysis of MHC class I molecules with bound peptide antigens. Seminars in Immunology. 5: 75-80. PMID 8504218 DOI: 10.1006/smim.1993.1011  1
1993 Fremont DH, Anderson DH, Wilson IA, Dennis EA, Xuong NH. Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association. Proceedings of the National Academy of Sciences of the United States of America. 90: 342-6. PMID 8419939  1
1992 Stura EA, Matsumura M, Fremont DH, Saito Y, Peterson PA, Wilson LA. Crystallization of murine major histocompatibility complex class I H-2Kb with single peptides Journal of Molecular Biology. 228: 975-982. PMID 1469730 DOI: 10.1016/0022-2836(92)90881-J  0.2
1992 Matsumura M, Fremont DH, Peterson PA, Wilson IA. Emerging principles for the recognition of peptide antigens by MHC class I molecules Science. 257: 927-934. PMID 1323878  1
1992 Fremont DH, Matsumura M, Stura EA, Peterson PA, Wilson IA. Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb Science. 257: 919-927. PMID 1323877  1
1991 Wilson IA, Stanfield RL, Rini JM, Arevalo JH, Schulze-Gahmen U, Fremont DH, Stura EA. Structural aspects of antibodies and antibody-antigen complexes. Ciba Foundation Symposium. 159: 13-28; discussion 28. PMID 1959445  1
1991 Wilson IA, Rini JM, Fremont DH, Fieser GG, Stura EA. X-ray crystallographic analysis of free and antigen-complexed Fab fragments to investigate structural basis of immune recognition. Methods in Enzymology. 203: 153-76. PMID 1762555  1
1987 Smith SG, Lewis M, Aschaffenburg R, Fenna RE, Wilson IA, Sundaralingam M, Stuart DI, Phillips DC. Crystallographic analysis of the three-dimensional structure of baboon alpha-lactalbumin at low resolution. Homology with lysozyme. The Biochemical Journal. 242: 353-60. PMID 3593255  0.68
1985 Skehel JJ, Brown E, Daniels RS, Douglas AR, Knossow M, Wilson IA, Wrigley NG, Wiley DC. Studies with monoclonal antibodies prepared against X-31 influenza virus haemagglutinin. Biochemical Society Transactions. 13: 12-4. PMID 2581826  0.4
1984 Skehel JJ, Stevens DJ, Daniels RS, Douglas AR, Knossow M, Wilson IA, Wiley DC. A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody. Proceedings of the National Academy of Sciences of the United States of America. 81: 1779-83. PMID 6584912  0.4
1983 Wilson IA, Ladner RC, Skehel JJ, Wiley DC. The structure and role of the carbohydrate moieties of influenza virus haemagglutinin. Biochemical Society Transactions. 11: 145-7. PMID 6873453  0.76
1983 Wilson IA, Ladner RC, Skehel JJ, Wiley DC. The structure and role of the carbohydrate moieties of influenza virus haemagglutinin. Biochemical Society Transactions. 11: 145-7. PMID 6662272  0.76
1983 Krystal M, Young JF, Palese P, Wilson IA, Skehel JJ, Wiley DC. Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains. Proceedings of the National Academy of Sciences of the United States of America. 80: 4527-31. PMID 6192436  0.76
1983 Rogers GN, Paulson JC, Daniels RS, Skehel JJ, Wilson IA, Wiley DC. Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature. 304: 76-8. PMID 6191220 DOI: 10.1038/304076a0  0.4
1982 Skehel JJ, Bayley PM, Brown EB, Martin SR, Waterfield MD, White JM, Wilson IA, Wiley DC. Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion. Proceedings of the National Academy of Sciences of the United States of America. 79: 968-72. PMID 6951181 DOI: 10.1073/pnas.79.4.968  0.4
1981 Wilson IA, Skehel JJ, Wiley DC. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature. 289: 366-73. PMID 7464906  0.76
1981 Wiley DC, Wilson IA, Skehel JJ. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature. 289: 373-8. PMID 6162101  0.76
1978 Petsko GA, Phillips DC, Williams RJ, Wilson IA. On the protein crystal chemistry of chloroplatinite ions: general principles and interactions with triose phosphate isomerase. Journal of Molecular Biology. 120: 345-59. PMID 650685 DOI: 10.1016/0022-2836(78)90423-0  0.68
1978 Phillips DC, Sternberg MJ, Thornton JM, Wilson IA. An analysis of the structure of triose phosphate isomerase and its comparison with lactate dehydrogenase. Journal of Molecular Biology. 119: 329-51. PMID 633372 DOI: 10.1016/0022-2836(78)90440-0  0.68
1977 Phillips DC, Rivers PS, Sternberg MJ, Thornton JM, Wilson IA. An analysis of the three-dimensional structure of chicken triose phosphate isomerase. Biochemical Society Transactions. 5: 642-7. PMID 902882  0.68
1976 Banner DW, Bloomer Ac, Petsko GA, Phillips DC, Wilson IA. Atomic coordinates for triose phosphate isomerase from chicken muscle. Biochemical and Biophysical Research Communications. 72: 146-55. PMID 985462 DOI: 10.1016/0006-291X(76)90963-3  0.68
1976 Browne CA, Campbell ID, Kiener PA, Phillips DC, Waley SG, Wilson IA. Studies of the histidine residues of triose phosphate isomerase by proton magnetic resonance and x-ray crystallography. Journal of Molecular Biology. 100: 319-43. PMID 3655 DOI: 10.1016/0002-9416(76)90098-1  0.68
1975 Banner DW, Bloomer AC, Petsko GA, Phillips DC, Pogson CI, Wilson IA, Corran PH, Furth AJ, Milman JD, Offord RE, Priddle JD, Waley SG. Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5 angstrom resolution using amino acid sequence data. Nature. 255: 609-14. PMID 1134550 DOI: 10.1038/255609a0  0.68
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