| Year |
Citation |
Score |
| 2020 |
Hsu JW, Bai M, Li K, Yang JS, Chu N, Cole PA, Eck MJ, Li J, Hsu VW. The protein kinase Akt acts as a coat adaptor in endocytic recycling. Nature Cell Biology. PMID 32541877 DOI: 10.1038/s41556-020-0530-z |
0.32 |
|
| 2019 |
De Clercq DJH, Heppner DE, To C, Jang J, Park E, Yun CH, Mushajiang M, Shin BH, Gero TW, Scott DA, Jänne PA, Eck MJ, Gray NS. Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. Acs Medicinal Chemistry Letters. 10: 1549-1553. PMID 31749909 DOI: 10.1021/acsmedchemlett.9b00381 |
0.44 |
|
| 2019 |
Park E, Rawson S, Li K, Kim BW, Ficarro SB, Pino GG, Sharif H, Marto JA, Jeon H, Eck MJ. Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature. PMID 31581174 DOI: 10.1038/s41586-019-1660-y |
0.4 |
|
| 2019 |
McNally R, Li Q, Li K, Dekker C, Vangrevelinghe E, Jones M, Chene P, Machauer R, Radimerski T, Eck MJ. Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain. Acs Chemical Biology. PMID 30763067 DOI: 10.1021/acschembio.8b00722 |
0.96 |
|
| 2017 |
Zhang J, Gao X, Schmit F, Adelmant G, Eck MJ, Marto JA, Zhao JJ, Roberts TM. CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells. Cell Reports. 20: 549-557. PMID 28723560 DOI: 10.1016/j.celrep.2017.06.054 |
0.36 |
|
| 2016 |
Ficarro SB, Browne CM, Card JD, Alexander WM, Zhang T, Park E, McNally R, Dhe-Paganon S, Seo HS, Lamberto I, Eck MJ, Buhrlage SJ, Gray NS, Marto JA. Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes. Analytical Chemistry. 88: 12248-12254. PMID 28193034 DOI: 10.1021/acs.analchem.6b03394 |
0.96 |
|
| 2016 |
Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T, Zhang H, Palakurthi S, Jang J, Lelais G, DiDonato M, Bursulaya B, ... ... Eck MJ, et al. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature. 534: 129-32. PMID 27251290 DOI: 10.1038/nature17960 |
1 |
|
| 2016 |
McNally R, Toms AV, Eck MJ. Crystal Structure of the FERM-SH2 Module of Human Jak2. Plos One. 11: e0156218. PMID 27227461 DOI: 10.1371/journal.pone.0156218 |
0.96 |
|
| 2016 |
Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Eck MJ, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/ncomms10882 |
0.84 |
|
| 2016 |
Fischer ES, Park E, Eck MJ, Thomä NH. SPLINTS: small-molecule protein ligand interface stabilizers. Current Opinion in Structural Biology. 37: 115-122. PMID 26829757 DOI: 10.1016/j.sbi.2016.01.004 |
1 |
|
| 2015 |
Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC. EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nature Structural & Molecular Biology. PMID 26551075 DOI: 10.1038/nsmb.3117 |
0.44 |
|
| 2015 |
Park E, Kim N, Ficarro SB, Zhang Y, Lee BI, Cho A, Kim K, Park AK, Park WY, Murray B, Meyerson M, Beroukhim R, Marto JA, Cho J, Eck MJ. Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nature Structural & Molecular Biology. 22: 703-11. PMID 26280531 DOI: 10.1038/nsmb.3074 |
0.44 |
|
| 2015 |
Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella KM, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, ... ... Eck MJ, et al. Development of Selective Covalent JAK3 Inhibitors. Journal of Medicinal Chemistry. PMID 26258521 DOI: 10.1021/acs.jmedchem.5b00710 |
0.96 |
|
| 2015 |
Wu SC, Li LS, Kopp N, Montero J, Chapuy B, Yoda A, Christie AL, Liu H, Christodoulou A, van Bodegom D, van der Zwet J, Layer JV, Tivey T, Lane AA, Ryan JA, ... ... Eck MJ, et al. Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia. Cancer Cell. 28: 29-41. PMID 26175414 DOI: 10.1016/j.ccell.2015.06.005 |
1 |
|
| 2015 |
Wu H, Hu C, Wang A, Weisberg EL, Chen Y, Yun CH, Wang W, Liu Y, Liu X, Tian B, Wang J, Zhao Z, Liang Y, Li B, Wang L, ... ... Eck MJ, et al. Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. PMID 26165234 DOI: 10.1038/leu.2015.180 |
0.56 |
|
| 2015 |
Park E, Graziano BR, Zheng W, Garabedian M, Goode BL, Eck MJ. Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif. Structure (London, England : 1993). PMID 26118535 DOI: 10.1016/j.str.2015.05.015 |
1 |
|
| 2015 |
Ercan D, Choi HG, Yun CH, Capelletti M, Xie T, Eck MJ, Gray NS, Janne PA. EGFR mutations and resistance to Irreversible pyrimidine based EGFR inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 25948633 DOI: 10.1158/1078-0432.CCR-14-2789 |
0.44 |
|
| 2015 |
Park E, Kim N, Ficarro SB, Zhang Y, Lee BI, Cho A, Kim K, Park AKJ, Park WY, Murray B, Meyerson M, Beroukhim R, Marto JA, Cho J, Eck MJ. Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6 Nature Structural and Molecular Biology. DOI: 10.1038/nsmb.3074 |
0.44 |
|
| 2014 |
Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discovery. 4: 1430-47. PMID 25252691 DOI: 10.1158/2159-8290.CD-13-0891 |
1 |
|
| 2014 |
Goñi GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska A, Martín MT, Eck MJ, Kremer L, Gräter F, Gervasio FL, Perez-Moreno M, Lietha D. Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proceedings of the National Academy of Sciences of the United States of America. 111: E3177-86. PMID 25049397 DOI: 10.1073/pnas.1317022111 |
1 |
|
| 2014 |
Cho J, Bass AJ, Lawrence MS, Cibulskis K, Cho A, Lee SN, Yamauchi M, Wagle N, Pochanard P, Kim N, Park AK, Won J, Hur HS, Greulich H, Ogino S, ... ... Eck MJ, et al. Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab. Molecular Cancer. 13: 141. PMID 24894453 DOI: 10.1186/1476-4598-13-141 |
1 |
|
| 2014 |
Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, et al. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 3: e01763. PMID 24844244 DOI: 10.7554/eLife.01763 |
1 |
|
| 2014 |
Eck M, Pham CV, Züfle S, Neukom M, Sessler M, Scheunemann D, Erdem E, Weber S, Borchert H, Ruhstaller B, Krüger M. Improved efficiency of bulk heterojunction hybrid solar cells by utilizing CdSe quantum dot-graphene nanocomposites. Physical Chemistry Chemical Physics : Pccp. 16: 12251-60. PMID 24820059 DOI: 10.1039/c4cp01566e |
1 |
|
| 2014 |
McNally R, Eck MJ. JAK-cytokine receptor recognition, unboxed. Nature Structural & Molecular Biology. 21: 431-3. PMID 24799036 DOI: 10.1038/nsmb.2824 |
1 |
|
| 2014 |
Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, ... ... Eck MJ, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discovery. 4: 452-65. PMID 24444711 DOI: 10.1158/2159-8290.CD-13-0646 |
1 |
|
| 2014 |
Yasuda H, Park E, Yun CH, Sng NJ, Lucena-Araujo AR, Yeo WL, Huberman MS, Cohen DW, Nakayama S, Ishioka K, Yamaguchi N, Hanna M, Oxnard GR, Lathan CS, Moran T, ... ... Eck MJ, et al. Structural, biochemical, and clinical characterization of Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutations in lung cancer (Science Translational Medicine (2014) 6, (225er1)) Science Translational Medicine. 6. DOI: 10.1126/scitranslmed.3008733 |
1 |
|
| 2014 |
Pham CV, Krueger M, Eck M, Weber S, Erdem E. Comparative electron paramagnetic resonance investigation of reduced graphene oxide and carbon nanotubes with different chemical functionalities for quantum dot attachment Applied Physics Letters. 104. DOI: 10.1063/1.4870297 |
1 |
|
| 2014 |
Eck M, Krueger M. Polymer-Nanocrystal Hybrid Solar Cells Organic Photovoltaics: Materials, Device Physics, and Manufacturing Technologies: Second Edition. 171-208. DOI: 10.1002/9783527656912.ch06 |
1 |
|
| 2013 |
Yasuda H, Park E, Yun CH, Sng NJ, Lucena-Araujo AR, Yeo WL, Huberman MS, Cohen DW, Nakayama S, Ishioka K, Yamaguchi N, Hanna M, Oxnard GR, Lathan CS, Moran T, ... ... Eck MJ, et al. Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Science Translational Medicine. 5: 216ra177. PMID 24353160 DOI: 10.1126/scitranslmed.3007205 |
1 |
|
| 2013 |
Cho J, Chen L, Sangji N, Okabe T, Yonesaka K, Francis JM, Flavin RJ, Johnson W, Kwon J, Yu S, Greulich H, Johnson BE, Eck MJ, Jänne PA, Wong KK, et al. Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization. Cancer Research. 73: 6770-9. PMID 24063894 DOI: 10.1158/0008-5472.CAN-13-1145 |
1 |
|
| 2013 |
Red Brewer M, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W. Mechanism for activation of mutated epidermal growth factor receptors in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: E3595-604. PMID 24019492 DOI: 10.1073/pnas.1220050110 |
1 |
|
| 2013 |
Toms AV, Deshpande A, McNally R, Jeong Y, Rogers JM, Kim CU, Gruner SM, Ficarro SB, Marto JA, Sattler M, Griffin JD, Eck MJ. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nature Structural & Molecular Biology. 20: 1221-3. PMID 24013208 DOI: 10.1038/nsmb.2673 |
1 |
|
| 2013 |
Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. Acs Chemical Biology. 8: 1931-8. PMID 23841803 DOI: 10.1021/cb400376p |
0.44 |
|
| 2013 |
Tu D, Zhu Z, Zhou AY, Yun CH, Lee KE, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, ... ... Eck MJ, et al. Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Reports. 3: 747-58. PMID 23453972 DOI: 10.1016/j.celrep.2013.01.033 |
1 |
|
| 2013 |
Brewer MR, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W. Mechanism for activation of mutated epidermal growth factor receptors in lung cancer (Proceedings of the National Academy of Sciences of the United States of America (2013) 110, 38 (E3595-E3604) DOI: 10.1073/pnas.1220050110) Proceedings of the National Academy of Sciences of the United States of America. 110: 20344. DOI: 10.1073/pnas.1320849110 |
1 |
|
| 2013 |
Pham CV, Eck M, Krueger M. Thiol functionalized reduced graphene oxide as a base material for novel graphene-nanoparticle hybrid composites Chemical Engineering Journal. 231: 146-154. DOI: 10.1016/j.cej.2013.07.007 |
1 |
|
| 2013 |
Krueger M, Eck M, Zhou Y, Riehle FS. Semiconducting Nanocrystal/Conjugated Polymer Composites for Applications in Hybrid Polymer Solar Cells Semiconducting Polymer Composites: Principles, Morphologies, Properties and Applications. 361-397. DOI: 10.1002/9783527648689.ch13 |
1 |
|
| 2012 |
Tu D, Graziano BR, Park E, Zheng W, Li Y, Goode BL, Eck MJ. Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6. Proceedings of the National Academy of Sciences of the United States of America. 109: E3424-33. PMID 23161908 DOI: 10.1073/pnas.1203035109 |
1 |
|
| 2012 |
Greulich H, Kaplan B, Mertins P, Chen TH, Tanaka KE, Yun CH, Zhang X, Lee SH, Cho J, Ambrogio L, Liao R, Imielinski M, Banerji S, Berger AH, Lawrence MS, ... ... Eck MJ, et al. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proceedings of the National Academy of Sciences of the United States of America. 109: 14476-81. PMID 22908275 DOI: 10.1073/pnas.1203201109 |
1 |
|
| 2012 |
Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H. Cyclic di-GMP sensing via the innate immune signaling protein STING. Molecular Cell. 46: 735-45. PMID 22705373 DOI: 10.1016/j.molcel.2012.05.029 |
1 |
|
| 2012 |
Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discovery. 2: 425-33. PMID 22588880 DOI: 10.1158/2159-8290.CD-12-0003 |
1 |
|
| 2012 |
Eck MJ, Hahn WC. EGFR in limbo. Cell. 149: 735-7. PMID 22579278 DOI: 10.1016/j.cell.2012.04.015 |
1 |
|
| 2012 |
Weigert O, Lane AA, Bird L, Kopp N, Chapuy B, van Bodegom D, Toms AV, Marubayashi S, Christie AL, McKeown M, Paranal RM, Bradner JE, Yoda A, Gaul C, Vangrevelinghe E, ... ... Eck MJ, et al. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. The Journal of Experimental Medicine. 209: 259-73. PMID 22271575 DOI: 10.1084/jem.20111694 |
1 |
|
| 2012 |
He M, Capelletti M, Nafa K, Yun CH, Arcila ME, Miller VA, Ginsberg MS, Zhao B, Kris MG, Eck MJ, Jänne PA, Ladanyi M, Oxnard GR. EGFR exon 19 insertions: a new family of sensitizing EGFR mutations in lung adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 1790-7. PMID 22190593 DOI: 10.1158/1078-0432.CCR-11-2361 |
1 |
|
| 2011 |
Hammerman PS, Sos ML, Ramos AH, Xu C, Dutt A, Zhou W, Brace LE, Woods BA, Lin W, Zhang J, Deng X, Lim SM, Heynck S, Peifer M, Simard JR, ... ... Eck MJ, et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discovery. 1: 78-89. PMID 22328973 DOI: 10.1158/2159-8274.CD-11-0005 |
1 |
|
| 2011 |
Chang F, Lemmon C, Lietha D, Eck M, Romer L. Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading. Plos One. 6: e28587. PMID 22163037 DOI: 10.1371/journal.pone.0028587 |
1 |
|
| 2011 |
Sasaki T, Koivunen J, Ogino A, Yanagita M, Nikiforow S, Zheng W, Lathan C, Marcoux JP, Du J, Okuda K, Capelletti M, Shimamura T, Ercan D, Stumpfova M, Xiao Y, ... ... Eck MJ, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Research. 71: 6051-60. PMID 21791641 DOI: 10.1158/0008-5472.CAN-11-1340 |
1 |
|
| 2011 |
Vizcarra CL, Kreutz B, Rodal AA, Toms AV, Lu J, Zheng W, Quinlan ME, Eck MJ. Structure and function of the interacting domains of Spire and Fmn-family formins. Proceedings of the National Academy of Sciences of the United States of America. 108: 11884-9. PMID 21730168 DOI: 10.1073/pnas.1105703108 |
1 |
|
| 2011 |
Tu D, Li Y, Song HK, Toms AV, Gould CJ, Ficarro SB, Marto JA, Goode BL, Eck MJ. Crystal structure of a coiled-coil domain from human ROCK I. Plos One. 6: e18080. PMID 21445309 DOI: 10.1371/journal.pone.0018080 |
1 |
|
| 2011 |
Krueger M, Zhou Y, Eck M. Inorganic-organic thin hybrid films for applications in bulk-heterojunction solar cells Aip Conference Proceedings. 1393: 19-22. DOI: 10.1063/1.3653598 |
1 |
|
| 2011 |
Albero J, Zhou Y, Eck M, Rauscher F, Niyamakom P, Dumsch I, Allard S, Scherf U, Krüger M, Palomares E. Photo-induced charge recombination kinetics in low bandgap PCPDTBT polymer:CdSe quantum dot bulk heterojunction solar cells Chemical Science. 2: 2396-2401. DOI: 10.1039/c1sc00514f |
1 |
|
| 2011 |
Zhou Y, Eck M, Men C, Rauscher F, Niyamakom P, Yilmaz S, Dumsch I, Allard S, Scherf U, Krüger M. Efficient polymer nanocrystal hybrid solar cells by improved nanocrystal composition Solar Energy Materials and Solar Cells. 95: 3227-3232. DOI: 10.1016/j.solmat.2011.07.015 |
1 |
|
| 2011 |
Zhou Y, Eck M, Veit C, Zimmermann B, Rauscher F, Niyamakom P, Yilmaz S, Dumsch I, Allard S, Scherf U, Krüger M. Efficiency enhancement for bulk-heterojunction hybrid solar cells based on acid treated CdSe quantum dots and low bandgap polymer PCPDTBT Solar Energy Materials and Solar Cells. 95: 1232-1237. DOI: 10.1016/j.solmat.2010.12.041 |
1 |
|
| 2010 |
Sasaki T, Okuda K, Zheng W, Butrynski J, Capelletti M, Wang L, Gray NS, Wilner K, Christensen JG, Demetri G, Shapiro GI, Rodig SJ, Eck MJ, Jänne PA. The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Research. 70: 10038-43. PMID 21030459 DOI: 10.1158/0008-5472.CAN-10-2956 |
1 |
|
| 2010 |
Frame MC, Patel H, Serrels B, Lietha D, Eck MJ. The FERM domain: organizing the structure and function of FAK. Nature Reviews. Molecular Cell Biology. 11: 802-14. PMID 20966971 DOI: 10.1038/nrm2996 |
1 |
|
| 2010 |
Nezami A, Poy F, Toms A, Zheng W, Eck MJ. Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins. Plos One. 5. PMID 20927338 DOI: 10.1371/journal.pone.0012992 |
1 |
|
| 2010 |
Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nature Structural & Molecular Biology. 17: 1175-81. PMID 20835240 DOI: 10.1038/nsmb.1907 |
1 |
|
| 2010 |
Smurnyy Y, Toms AV, Hickson GR, Eck MJ, Eggert US. Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. Acs Chemical Biology. 5: 1015-20. PMID 20804174 DOI: 10.1021/cb1001685 |
1 |
|
| 2010 |
Eck MJ, Yun CH. Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer. Biochimica Et Biophysica Acta. 1804: 559-66. PMID 20026433 DOI: 10.1016/j.bbapap.2009.12.010 |
1 |
|
| 2010 |
Zhou Y, Eck M, Krüger M. Bulk-heterojunction hybrid solar cells based on colloidal nanocrystals and conjugated polymers Energy and Environmental Science. 3: 1851-1864. DOI: 10.1039/c0ee00143k |
1 |
|
| 2009 |
Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 462: 1070-4. PMID 20033049 DOI: 10.1038/nature08622 |
1 |
|
| 2009 |
Eck MJ, Manley PW. The interplay of structural information and functional studies in kinase drug design: insights from BCR-Abl. Current Opinion in Cell Biology. 21: 288-95. PMID 19217274 DOI: 10.1016/j.ceb.2009.01.014 |
1 |
|
| 2009 |
Paust N, Litterst C, Metz T, Eck M, Ziegler C, Zengerle R, Koltay P. Capillary-driven pumping for passive degassing and fuel supply in direct methanol fuel cells Microfluidics and Nanofluidics. 7: 531-543. DOI: 10.1007/s10404-009-0414-9 |
1 |
|
| 2008 |
Lietha D, Eck MJ. Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. Plos One. 3: e3800. PMID 19030106 DOI: 10.1371/journal.pone.0003800 |
1 |
|
| 2008 |
Swanson KD, Tang Y, Ceccarelli DF, Poy F, Sliwa JP, Neel BG, Eck MJ. The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch. Molecular Cell. 32: 564-75. PMID 19026786 DOI: 10.1016/j.molcel.2008.09.022 |
1 |
|
| 2008 |
Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proceedings of the National Academy of Sciences of the United States of America. 105: 2070-5. PMID 18227510 DOI: 10.1073/pnas.0709662105 |
1 |
|
| 2008 |
Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, Hahn KM, Eck MJ, Schaller MD. Spatial and temporal regulation of focal adhesion kinase activity in living cells. Molecular and Cellular Biology. 28: 201-14. PMID 17967873 DOI: 10.1128/MCB.01324-07 |
1 |
|
| 2007 |
Li D, Shimamura T, Ji H, Chen L, Haringsma HJ, McNamara K, Liang MC, Perera SA, Zaghlul S, Borgman CL, Kubo S, Takahashi M, Sun Y, Chirieac LR, Padera RF, ... ... Eck MJ, et al. Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell. 12: 81-93. PMID 17613438 DOI: 10.1016/j.ccr.2007.06.005 |
1 |
|
| 2007 |
Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. Structural basis for the autoinhibition of focal adhesion kinase. Cell. 129: 1177-87. PMID 17574028 DOI: 10.1016/j.cell.2007.05.041 |
1 |
|
| 2007 |
Lu J, Meng W, Poy F, Maiti S, Goode BL, Eck MJ. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. Journal of Molecular Biology. 369: 1258-69. PMID 17482208 DOI: 10.1016/j.jmb.2007.04.002 |
1 |
|
| 2007 |
Goode BL, Eck MJ. Mechanism and function of formins in the control of actin assembly. Annual Review of Biochemistry. 76: 593-627. PMID 17373907 DOI: 10.1146/annurev.biochem.75.103004.142647 |
1 |
|
| 2007 |
Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ. Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell. 11: 217-27. PMID 17349580 DOI: 10.1016/j.ccr.2006.12.017 |
1 |
|
| 2007 |
Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nature Chemical Biology. 3: 229-38. PMID 17334377 DOI: 10.1038/nchembio866 |
0.44 |
|
| 2006 |
Ji H, Zhao X, Yuza Y, Shimamura T, Li D, Protopopov A, Jung BL, McNamara K, Xia H, Glatt KA, Thomas RK, Sasaki H, Horner JW, Eck M, Mitchell A, et al. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 103: 7817-22. PMID 16672372 DOI: 10.1073/pnas.0510284103 |
1 |
|
| 2006 |
Nezami AG, Poy F, Eck MJ. Structure of the autoinhibitory switch in formin mDia1. Structure (London, England : 1993). 14: 257-63. PMID 16472745 DOI: 10.1016/j.str.2005.12.003 |
1 |
|
| 2006 |
Ceccarelli DF, Song HK, Poy F, Schaller MD, Eck MJ. Crystal structure of the FERM domain of focal adhesion kinase. The Journal of Biological Chemistry. 281: 252-9. PMID 16221668 DOI: 10.1074/jbc.M509188200 |
1 |
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| 2005 |
Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, ... ... Eck MJ, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 7: 387-97. PMID 15837627 DOI: 10.1016/j.ccr.2005.03.023 |
1 |
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| 2005 |
Boggon TJ, Li Y, Manley PW, Eck MJ. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood. 106: 996-1002. PMID 15831699 DOI: 10.1182/blood-2005-02-0707 |
1 |
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| 2005 |
Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. The New England Journal of Medicine. 352: 786-92. PMID 15728811 DOI: 10.1056/NEJMoa044238 |
1 |
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| 2004 |
Boggon TJ, Eck MJ. Structure and regulation of Src family kinases. Oncogene. 23: 7918-27. PMID 15489910 DOI: 10.1038/sj.onc.1208081 |
1 |
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| 2004 |
Kung AL, Zabludoff SD, France DS, Freedman SJ, Tanner EA, Vieira A, Cornell-Kennon S, Lee J, Wang B, Wang J, Memmert K, Naegeli HU, Petersen F, Eck MJ, Bair KW, et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell. 6: 33-43. PMID 15261140 DOI: 10.1016/j.ccr.2004.06.009 |
1 |
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| 2004 |
Jiang J, Paez JG, Lee JC, Bo R, Stone RM, DeAngelo DJ, Galinsky I, Wolpin BM, Jonasova A, Herman P, Fox EA, Boggon TJ, Eck MJ, Weisberg E, Griffin JD, et al. Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML. Blood. 104: 1855-8. PMID 15178581 DOI: 10.1182/blood-2004-02-0712 |
1 |
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| 2004 |
Dunty JM, Gabarra-Niecko V, King ML, Ceccarelli DF, Eck MJ, Schaller MD. FERM domain interaction promotes FAK signaling. Molecular and Cellular Biology. 24: 5353-68. PMID 15169899 DOI: 10.1128/MCB.24.12.5353-5368.2004 |
1 |
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| 2004 |
Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science (New York, N.Y.). 304: 1497-500. PMID 15118125 DOI: 10.1126/science.1099314 |
1 |
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| 2004 |
Simarro M, Lanyi A, Howie D, Poy F, Bruggeman J, Choi M, Sumegi J, Eck MJ, Terhorst C. SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9. International Immunology. 16: 727-36. PMID 15096483 DOI: 10.1093/intimm/dxh074 |
1 |
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| 2004 |
Xu Y, Moseley JB, Sagot I, Poy F, Pellman D, Goode BL, Eck MJ. Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture. Cell. 116: 711-23. PMID 15006353 DOI: 10.1016/S0092-8674(04)00210-7 |
1 |
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| 2004 |
Moseley JB, Sagot I, Manning AL, Xu Y, Eck MJ, Pellman D, Goode BL. A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin. Molecular Biology of the Cell. 15: 896-907. PMID 14657240 DOI: 10.1091/mbc.E03-08-0621 |
1 |
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| 2003 |
Towbin H, Bair KW, DeCaprio JA, Eck MJ, Kim S, Kinder FR, Morollo A, Mueller DR, Schindler P, Song HK, van Oostrum J, Versace RW, Voshol H, Wood J, Zabludoff S, et al. Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. The Journal of Biological Chemistry. 278: 52964-71. PMID 14534293 DOI: 10.1074/jbc.M309039200 |
1 |
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| 2003 |
Engel P, Eck MJ, Terhorst C. The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nature Reviews. Immunology. 3: 813-21. PMID 14523387 DOI: 10.1038/nri1202 |
1 |
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| 2003 |
Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science (New York, N.Y.). 301: 1725-8. PMID 14500983 DOI: 10.1126/science.1085643 |
1 |
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| 2003 |
Song HK, Eck MJ. Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine. Molecular Cell. 12: 75-86. PMID 12887894 DOI: 10.1016/S1097-2765(03)00271-5 |
1 |
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| 2003 |
Wang JH, Eck MJ. Assembling atomic resolution views of the immunological synapse. Current Opinion in Immunology. 15: 286-93. PMID 12787753 DOI: 10.1016/S0952-7915(03)00055-4 |
1 |
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| 2003 |
Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G, Eck MJ. Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nature Structural Biology. 10: 504-12. PMID 12778114 DOI: 10.1038/nsb936 |
1 |
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| 2003 |
Stolt PC, Jeon H, Song HK, Herz J, Eck MJ, Blacklow SC. Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure (London, England : 1993). 11: 569-79. PMID 12737822 DOI: 10.1016/S0969-2126(03)00068-6 |
1 |
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| 2003 |
Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. The Journal of Biological Chemistry. 278: 13462-7. PMID 12556468 DOI: 10.1074/jbc.M210483200 |
1 |
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| 2003 |
Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ. SAP couples Fyn to SLAM immune receptors. Nature Cell Biology. 5: 155-60. PMID 12545174 DOI: 10.1038/ncb920 |
1 |
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| 2003 |
Summy JM, Sudol M, Eck MJ, Monteiro AN, Gatesman A, Flynn DC. Specificity in signaling by c-Yes. Frontiers in Bioscience : a Journal and Virtual Library. 8: s185-205. PMID 12456296 |
1 |
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| 2002 |
Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proceedings of the National Academy of Sciences of the United States of America. 99: 5367-72. PMID 11959990 DOI: 10.1073/pnas.082117899 |
1 |
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| 2001 |
Poy F, Lepourcelet M, Shivdasani RA, Eck MJ. Structure of a human Tcf4-beta-catenin complex. Nature Structural Biology. 8: 1053-7. PMID 11713476 DOI: 10.1038/nsb720 |
1 |
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| 2001 |
Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, et al. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. The Embo Journal. 20: 5840-52. PMID 11689425 DOI: 10.1093/emboj/20.21.5840 |
1 |
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| 2001 |
Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. The Journal of Biological Chemistry. 276: 36809-16. PMID 11477068 DOI: 10.1074/jbc.M101305200 |
1 |
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| 2001 |
Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nature Structural Biology. 8: 499-504. PMID 11373616 DOI: 10.1038/88556 |
1 |
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| 2001 |
Morollo AA, Eck MJ. Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium. Nature Structural Biology. 8: 243-7. PMID 11224570 DOI: 10.1038/84988 |
1 |
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| 2000 |
Sawasdikosol S, Pratt JC, Meng W, Eck MJ, Burakoff SJ. Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase. Biochimica Et Biophysica Acta. 1471: M1-M12. PMID 11004605 DOI: 10.1016/S0304-419X(00)00013-5 |
1 |
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| 2000 |
Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell. 102: 387-97. PMID 10975528 |
1 |
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| 2000 |
Huang X, Poy F, Zhang R, Joachimiak A, Sudol M, Eck MJ. Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan. Nature Structural Biology. 7: 634-8. PMID 10932245 DOI: 10.1038/77923 |
1 |
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| 1999 |
Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Molecular Cell. 4: 555-61. PMID 10549287 DOI: 10.1016/S1097-2765(00)80206-3 |
1 |
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| 1999 |
Lupher ML, Rao N, Eck MJ, Band H. The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. Immunology Today. 20: 375-82. PMID 10431158 DOI: 10.1016/S0167-5699(99)01484-X |
1 |
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| 1999 |
Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE. Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. Proceedings of the National Academy of Sciences of the United States of America. 96: 8378-83. PMID 10411883 DOI: 10.1073/pnas.96.15.8378 |
1 |
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| 1999 |
Xu W, Doshi A, Lei M, Eck MJ, Harrison SC. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Molecular Cell. 3: 629-38. PMID 10360179 DOI: 10.1016/S1097-2765(00)80356-1 |
1 |
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| 1999 |
Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature. 398: 84-90. PMID 10078535 DOI: 10.1038/18050 |
1 |
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| 1998 |
Huse M, Eck MJ, Harrison SC. A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck. The Journal of Biological Chemistry. 273: 18729-33. PMID 9668045 DOI: 10.1074/jbc.273.30.18729 |
1 |
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| 1998 |
Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE. Crystal structure of the tyrosine phosphatase SHP-2. Cell. 92: 441-50. PMID 9491886 DOI: 10.1016/S0092-8674(00)80938-1 |
1 |
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| 1998 |
Sondhi D, Xu W, Songyang Z, Eck MJ, Cole PA. Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism. Biochemistry. 37: 165-72. PMID 9425036 DOI: 10.1021/bi9722960 |
1 |
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| 1997 |
Xu W, Harrison SC, Eck MJ. Three-dimensional structure of the tyrosine kinase c-Src. Nature. 385: 595-602. PMID 9024657 DOI: 10.1038/385595a0 |
1 |
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| 1996 |
Weissenhorn W, Eck MJ, Harrison SC, Wiley DC. Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro. European Journal of Biochemistry / Febs. 238: 440-5. PMID 8681956 |
1 |
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| 1996 |
Eck MJ, Dhe-Paganon S, Trüb T, Nolte RT, Shoelson SE. Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell. 85: 695-705. PMID 8646778 DOI: 10.1016/S0092-8674(00)81236-2 |
1 |
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| 1996 |
Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC. Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes. Nature Structural Biology. 3: 364-74. PMID 8599763 |
1 |
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| 1996 |
Eck MJ, Pluskey S, Trüb T, Harrison SC, Shoelson SE. Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature. 379: 277-80. PMID 8538796 DOI: 10.1038/379277a0 |
1 |
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| 1995 |
Songyang Z, Carraway KL, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature. 373: 536-9. PMID 7845468 DOI: 10.1038/373536a0 |
1 |
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| 1995 |
Eck MJ. A new flavor in phosphotyrosine recognition. Structure (London, England : 1993). 3: 421-4. PMID 7545066 DOI: 10.1016/S0969-2126(01)00173-3 |
1 |
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| 1995 |
Mayer BJ, Eck MJ. SH3 domains. Minding your p's and q's. Current Biology : Cb. 5: 364-7. PMID 7542990 DOI: 10.1016/S0960-9822(95)00073-X |
1 |
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| 1994 |
Rodseth LE, Brandhuber B, Devine TQ, Eck MJ, Hale K, Naismith JH, Sprang SR. Two crystal forms of the extracellular domain of type I tumor necrosis factor receptor. Journal of Molecular Biology. 239: 332-5. PMID 8196061 DOI: 10.1006/jmbi.1994.1371 |
1 |
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| 1994 |
Eck MJ, Atwell SK, Shoelson SE, Harrison SC. Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature. 368: 764-9. PMID 7512222 DOI: 10.1038/368764a0 |
1 |
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| 1993 |
Eck MJ, Shoelson SE, Harrison SC. Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature. 362: 87-91. PMID 7680435 DOI: 10.1038/362087a0 |
1 |
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| 1992 |
Eck MJ, Ultsch M, Rinderknecht E, de Vos AM, Sprang SR. The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution. The Journal of Biological Chemistry. 267: 2119-22. PMID 1733919 |
1 |
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| 1989 |
Eck MJ, Sprang SR. The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding. The Journal of Biological Chemistry. 264: 17595-605. PMID 2551905 |
1 |
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| 1988 |
Eck MJ, Beutler B, Kuo G, Merryweather JP, Sprang SR. Crystallization of trimeric recombinant human tumor necrosis factor (cachectin). The Journal of Biological Chemistry. 263: 12816-9. PMID 3417634 |
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