Robert J. Fletterick - Publications

Biochemistry University of California, San Francisco, San Francisco, CA 
X-ray crystal structures of nuclear receptors, kinesin molecular motors, clathrin, and many enzymes

250 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM. Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell Chemical Biology. PMID 30853418 DOI: 10.1016/j.chembiol.2019.02.002  0.56
2018 Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nature Communications. 9: 4055. PMID 30305617 DOI: 10.1038/s41467-018-06137-w  0.6
2017 Cortez FJ, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. Development of 5N-Bicalutamide, A High-affinity Reversible Covalent Antiandrogen. Acs Chemical Biology. PMID 28981251 DOI: 10.1021/acschembio.7b00702  0.56
2016 de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). Plos One. 11: e0159316. PMID 27467220 DOI: 10.1371/journal.pone.0159316  0.56
2016 Proudfoot A, Axelrod HL, Geralt M, Fletterick RJ, Yumoto F, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K, Serrano P. Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. Journal of Molecular Biology. 428: 1130-1141. PMID 26829219 DOI: 10.1016/j.jmb.2016.01.023  0.44
2015 Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. A gene-expression screen identifies a non-toxic sumoylation inhibitor that Mimics SUMO-less human LRH-1 in liver. Elife. 4. PMID 26653140 DOI: 10.7554/eLife.09003  0.56
2015 Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ. Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. Journal of Structural Biology. PMID 26416531 DOI: 10.1016/j.jsb.2015.09.012  1
2015 Storer Samaniego C, Suh JH, Chattopadhyay A, Olivares K, Guy N, Sivils JC, Dey P, Yumoto F, Fletterick RJ, Strom AM, Gustafsson JÅ, Webb P, Cox MB. The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. Plos One. 10: e0134015. PMID 26207810 DOI: 10.1371/journal.pone.0134015  0.56
2015 Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, ... ... Fletterick RJ, et al. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 4666-71. PMID 25825768 DOI: 10.1073/pnas.1502855112  1
2015 Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG. Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nature Communications. 6: 6204. PMID 25686748 DOI: 10.1038/ncomms7204  1
2015 Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proceedings of the National Academy of Sciences of the United States of America. 112: 2467-72. PMID 25675535 DOI: 10.1073/pnas.1500978112  1
2015 Gallastegui N, Mackinnon JA, Fletterick RJ, Estébanez-Perpiñá E. Advances in our structural understanding of orphan nuclear receptors. Trends in Biochemical Sciences. 40: 25-35. PMID 25499868 DOI: 10.1016/j.tibs.2014.11.002  1
2014 Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proceedings of the National Academy of Sciences of the United States of America. 111: 15054-9. PMID 25288771 DOI: 10.1073/pnas.1416740111  1
2014 Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable. Plos One. 9: e99440. PMID 24936658 DOI: 10.1371/journal.pone.0099440  1
2014 Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÃ…, Fletterick RJ, Jacobson RH, Webb P. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proceedings of the National Academy of Sciences of the United States of America. 111: 9103-8. PMID 24927529 DOI: 10.1073/pnas.1408293111  1
2014 Nagavalli S, Fletterick RJ, Ford G, Boston BA, Gianoukakis AG. Computer modeling of a newly identified THRB gene mutation (S350L) associated with resistance to thyroid hormone in three unrelated patients. Thyroid : Official Journal of the American Thyroid Association. 24: 1430-1. PMID 24906004 DOI: 10.1089/thy.2014.0086  1
2013 Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE. Incidental identification of a thyroid hormone receptor beta (THRB) gene variant in a family with autoimmune thyroid disease Thyroid. 23: 1638-1643. PMID 23806029 DOI: 10.1089/thy.2013.0174  1
2013 Vinogradova MV, Malanina GG, Waitzman JS, Rice SE, Fletterick RJ. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. Plos One. 8: e66669. PMID 23805258 DOI: 10.1371/journal.pone.0066669  1
2013 Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. Structure-based discovery of antagonists of nuclear receptor LRH-1. The Journal of Biological Chemistry. 288: 19830-44. PMID 23667258 DOI: 10.1074/jbc.M112.411686  1
2012 Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, ... Fletterick RJ, et al. Structure of a novel winged-helix like domain from human NFRKB protein. Plos One. 7: e43761. PMID 22984442 DOI: 10.1371/journal.pone.0043761  1
2012 Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. Structural basis of coactivation of liver receptor homolog-1 by β-catenin. Proceedings of the National Academy of Sciences of the United States of America. 109: 143-8. PMID 22187462 DOI: 10.1073/pnas.1117036108  1
2012 Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E. A conserved surface on the ligand binding domain of nuclear receptors for allosteric control. Molecular and Cellular Endocrinology. 348: 394-402. PMID 21878368 DOI: 10.1016/j.mce.2011.08.012  1
2011 Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proceedings of the National Academy of Sciences of the United States of America. 108: 16927-31. PMID 21949357 DOI: 10.1073/pnas.1112047108  1
2011 De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, et al. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 11878-83. PMID 21730179 DOI: 10.1073/pnas.1105160108  1
2010 Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA. Decoration of microtubules in solution by the kinesin-14, Ncd. Acta Crystallographica. Section D, Biological Crystallography. 66: 1218-23. PMID 21041940 DOI: 10.1107/S0907444910021323  1
2010 Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Developmental Cell. 18: 841-8. PMID 20493816 DOI: 10.1016/j.devcel.2010.04.007  1
2010 Pfaff SJ, Fletterick RJ. Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled. The Journal of Biological Chemistry. 285: 15256-67. PMID 20335180 DOI: 10.1074/jbc.M110.108118  1
2010 Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallographica. Section D, Biological Crystallography. 66: 314-8. PMID 20179344 DOI: 10.1107/S0907444909054535  1
2009 Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ. Structure of the complex of a mitotic kinesin with its calcium binding regulator. Proceedings of the National Academy of Sciences of the United States of America. 106: 8175-9. PMID 19416847 DOI: 10.1073/pnas.0811131106  1
2009 Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Molecular Endocrinology (Baltimore, Md.). 23: 25-34. PMID 18988706 DOI: 10.1210/me.2007-0508  1
2009 Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ. Molecular basis for dimer formation of TRbeta variant D355R. Proteins. 75: 111-7. PMID 18798561 DOI: 10.1002/prot.22225  1
2009 Estébanez-Perpiñá E, Fletterick RJ. The androgen receptor coactivator-binding interface Androgen Action in Prostate Cancer. 297-311. DOI: 10.1007/978-0-387-69179-4_13  1
2008 Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proceedings of the National Academy of Sciences of the United States of America. 105: 18390-5. PMID 19015525 DOI: 10.1073/pnas.0808936105  1
2008 Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. The Journal of Biological Chemistry. 283: 32870-9. PMID 18790740 DOI: 10.1074/jbc.M802863200  1
2008 Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. Journal of Medicinal Chemistry. 51: 5856-60. PMID 18754610 DOI: 10.1021/jm701517b  1
2008 Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ. Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. Journal of Structural Biology. 163: 76-83. PMID 18513992 DOI: 10.1016/j.jsb.2008.04.004  1
2007 Estébanez-Perpiñá E, Jouravel N, Fletterick RJ. Perspectives on designs of antiandrogens for prostate cancer. Expert Opinion On Drug Discovery. 2: 1341-55. PMID 23484530 DOI: 10.1517/17460441.2.10.1341  1
2007 Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallographica. Section D, Biological Crystallography. 63: 1198-200. PMID 18007036 DOI: 10.1107/S0907444907045702  1
2007 Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. Journal of Medicinal Chemistry. 50: 5269-80. PMID 17918822 DOI: 10.1021/jm070556y  1
2007 Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proceedings of the National Academy of Sciences of the United States of America. 104: 16074-9. PMID 17911242 DOI: 10.1073/pnas.0708036104  0.56
2007 Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Molecular Endocrinology (Baltimore, Md.). 21: 2919-28. PMID 17823305 DOI: 10.1210/me.2007-0174  1
2007 Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure (London, England : 1993). 15: 535-43. PMID 17502099 DOI: 10.1016/j.str.2007.03.012  1
2007 Vinogradova MV, Stone DB, Malanina GG, Mendelson RA, Fletterick RJ. Ca ion and the troponin switch. Advances in Experimental Medicine and Biology. 592: 47-57. PMID 17278355 DOI: 10.1007/978-4-431-38453-3_6  1
2006 Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A. Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. Journal of Molecular Biology. 363: 75-97. PMID 16962610 DOI: 10.1016/j.jmb.2006.07.027  1
2006 Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proceedings of the National Academy of Sciences of the United States of America. 103: 11503-8. PMID 16864794 DOI: 10.1073/pnas.0600489103  1
2006 Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Science's Stke : Signal Transduction Knowledge Environment. 2006: pl3. PMID 16804159 DOI: 10.1126/stke.3412006pl3  1
2006 Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W. An atomic model of the thin filament in the relaxed and Ca2+-activated states. Journal of Molecular Biology. 357: 707-17. PMID 16469331 DOI: 10.1016/j.jmb.2005.12.050  1
2006 Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. Dynamics of the C-terminal region of TnI in the troponin complex in solution. Biophysical Journal. 90: 2436-44. PMID 16415057 DOI: 10.1529/biophysj.105.076216  1
2005 Fletterick RJ. Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer. Bju International. 96: 2-9. PMID 16359432 DOI: 10.1111/j.1464-410X.2005.05940.x  1
2005 Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. The Journal of Biological Chemistry. 280: 43048-55. PMID 16263725 DOI: 10.1074/jbc.M506693200  1
2005 Togashi M, Nguyen P, Fletterick R, Baxter JD, Webb P. Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5′,5-triiodo-L-thyronine and inhibit homodimer formation Journal of Biological Chemistry. 280: 25665-25673. PMID 15886199 DOI: 10.1074/jbc.M501615200  1
2005 Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P, Baxter JD. Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. The Journal of Steroid Biochemistry and Molecular Biology. 93: 127-37. PMID 15860255 DOI: 10.1016/j.jsbmb.2005.01.004  1
2005 Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex. The Journal of Biological Chemistry. 280: 21924-32. PMID 15826946 DOI: 10.1074/jbc.M500574200  1
2005 Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ. Ca(2+)-regulated structural changes in troponin. Proceedings of the National Academy of Sciences of the United States of America. 102: 5038-43. PMID 15784741 DOI: 10.1073/pnas.0408882102  1
2005 Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, ... ... Fletterick RJ, et al. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 120: 343-55. PMID 15707893 DOI: 10.1016/j.cell.2005.01.024  1
2005 Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. The Journal of Biological Chemistry. 280: 8060-8. PMID 15563469 DOI: 10.1074/jbc.M407046200  1
2004 Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD. Thyroxine-thyroid hormone receptor interactions. The Journal of Biological Chemistry. 279: 55801-8. PMID 15466465 DOI: 10.1074/jbc.M410124200  0.36
2004 Hur E, Pfaff SJ, Payne ES, Grøn H, Buehrer BM, Fletterick RJ. Recognition and accommodation at the androgen receptor coactivator binding interface. Plos Biology. 2: E274. PMID 15328534 DOI: 10.1371/journal.pbio.0020274  1
2004 Ruggles SW, Fletterick RJ, Craik CS. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. The Journal of Biological Chemistry. 279: 30751-9. PMID 15123647 DOI: 10.1074/jbc.M400949200  1
2004 Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, Fletterick R. Structure of a kinesin microtubule depolymerization machine Embo Journal. 23: 1422-1432. PMID 15029249 DOI: 10.1038/sj.emboj.7600165  1
2004 Vinogradova MV, Reddy VS, Reddy AS, Sablin EP, Fletterick RJ. Crystal structure of kinesin regulated by Ca(2+)-calmodulin. The Journal of Biological Chemistry. 279: 23504-9. PMID 14988396 DOI: 10.1074/jbc.M400741200  1
2004 Sablin EP, Fletterick RJ. Coordination between motor domains in processive kinesins. The Journal of Biological Chemistry. 279: 15707-10. PMID 14973135 DOI: 10.1074/jbc.R300036200  1
2003 Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, Webb P, Baxter JD, Scanlan TS, Fletterick RJ. Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proceedings of the National Academy of Sciences of the United States of America. 100: 15358-63. PMID 14673100 DOI: 10.1073/pnas.2136689100  1
2003 Wang SX, Hur E, Sousa CA, Brinen L, Slivka EJ, Fletterick RJ. The extended interactions and Gla domain of blood coagulation factor Xa. Biochemistry. 42: 7959-66. PMID 12834348 DOI: 10.1021/bi027320a  1
2003 Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Molecular Cell. 11: 1575-85. PMID 12820970 DOI: 10.1016/S1097-2765(03)00236-3  1
2003 Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nature Structural Biology. 10: 527-34. PMID 12819769 DOI: 10.1038/nsb944  1
2003 Huber BR, Sandler B, West BL, Cunha Lima ST, Nguyen HT, Apriletti JW, Baxter JD, Fletterick RJ. Two resistance to thyroid hormone mutants with impaired hormone binding. Molecular Endocrinology (Baltimore, Md.). 17: 643-52. PMID 12554782 DOI: 10.1210/me.2002-0095  1
2003 Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ. Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain. Molecular Endocrinology (Baltimore, Md.). 17: 107-16. PMID 12511610 DOI: 10.1210/me.2002-0097  1
2003 Dawson JF, Sablin EP, Spudich JA, Fletterick RJ. Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing. The Journal of Biological Chemistry. 278: 1229-38. PMID 12356759 DOI: 10.1074/jbc.M209160200  1
2002 Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, et al. Design of thyroid hormone receptor antagonists from first principles. The Journal of Steroid Biochemistry and Molecular Biology. 83: 59-73. PMID 12650702 DOI: 10.1016/S0960-0760(02)00270-4  1
2002 Sindelar CV, Budny MJ, Rice S, Naber N, Fletterick R, Cooke R. Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nature Structural Biology. 9: 844-8. PMID 12368902 DOI: 10.1038/nsb852  1
2002 Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA. Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Molecular and Cellular Biology. 22: 7193-203. PMID 12242296 DOI: 10.1128/MCB.22.20.7193-7203.2002  1
2002 Ekstrom JL, Pauly TA, Carty MD, Soeller WC, Culp J, Danley DE, Hoover DJ, Treadway JL, Gibbs EM, Fletterick RJ, Day YS, Myszka DG, Rath VL. Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chemistry & Biology. 9: 915-24. PMID 12204691 DOI: 10.1016/S1074-5521(02)00186-2  1
2002 Sablin EP, Dawson JF, VanLoock MS, Spudich JA, Egelman EH, Fletterick RJ. How does ATP hydrolysis control actin's associations? Proceedings of the National Academy of Sciences of the United States of America. 99: 10945-7. PMID 12167670 DOI: 10.1073/pnas.152329899  1
2002 Walther M, Anton M, Wiedmann M, Fletterick R, Kuhn H. The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding Journal of Biological Chemistry. 277: 27360-27366. PMID 12004065 DOI: 10.1074/jbc.M203234200  1
2002 Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS. Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. The Journal of Biological Chemistry. 277: 26623-31. PMID 11959867 DOI: 10.1074/jbc.M203076200  1
2002 Marimuthu A, Feng W, Tagami T, Nguyen H, Jameson JL, Fletterick RJ, Baxter JD, West BL. TR surfaces and conformations required to bind nuclear receptor corepressor. Molecular Endocrinology (Baltimore, Md.). 16: 271-86. PMID 11818500 DOI: 10.1210/mend.16.2.0777  1
2002 Baxter JD, Goede P, Apriletti JW, West BL, Feng W, Mellstrom K, Fletterick RJ, Wagner RL, Kushner PJ, Ribeiro RC, Webb P, Scanlan TS, Nilsson S. Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology. 143: 517-24. PMID 11796506 DOI: 10.1210/endo.143.2.8617  1
2002 Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N. Cryo-EM and X-ray crystallographic studies on the monomeric kinesin motor KIF1A Microscopy and Microanalysis. 8: 210.  1
2001 Sablin EP, Fletterick RJ. Nucleotide switches in molecular motors: structural analysis of kinesins and myosins. Current Opinion in Structural Biology. 11: 716-24. PMID 11751053 DOI: 10.1016/S0959-440X(01)00265-2  1
2001 Martin MA, Rubio JC, Buchbinder J, Fernandez-Hojas R, Hoyo PD, Gamez J, Navarro C, Fernandez JM, Cabello A, Campos Y, Cervera C, Culebras JM, Andreu AL, Fletterick R, Arenas J. Molecular heterogeneity of myophosphorylase deficiency (McArdle's disease): A genotype-phenotype correlation study Annals of Neurology. 50: 574-581. PMID 11706962 DOI: 10.1002/ana.1225  1
2001 Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 40: 10038-46. PMID 11513582 DOI: 10.1021/bi010712h  1
2001 Kapila Y, Doan D, Tafolla E, Fletterick R. Three-dimensional structural analysis of fibronectin heparin-binding domain mutations Journal of Cellular Biochemistry. Supplement. 156-161. PMID 11455580  1
2001 Baxter JD, Dillmann WH, West BL, Huber R, Furlow JD, Fletterick RJ, Webb P, Apriletti JW, Scanlan TS. Selective modulation of thyroid hormone receptor action. The Journal of Steroid Biochemistry and Molecular Biology. 76: 31-42. PMID 11384861 DOI: 10.1016/S0960-0760(01)00052-8  1
2001 Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N. Switch-based mechanism of kinesin motors. Nature. 411: 439-45. PMID 11373668 DOI: 10.1038/35078000  1
2001 Eggers CT, Wang SX, Fletterick RJ, Craik CS. The role of ecotin dimerization in protease inhibition. Journal of Molecular Biology. 308: 975-91. PMID 11352586 DOI: 10.1006/jmbi.2001.4754  1
2001 Buchbinder JL, Rath VL, Fletterick RJ. Structural relationships among regulated and unregulated phosphorylases. Annual Review of Biophysics and Biomolecular Structure. 30: 191-209. PMID 11340058 DOI: 10.1146/annurev.biophys.30.1.191  1
2001 Turner J, Anderson R, Guo J, Beraud C, Fletterick R, Sakowicz R. Crystal Structure of the Mitotic Spindle Kinesin Eg5 Reveals a Novel Conformation of the Neck-linker Journal of Biological Chemistry. 276: 25496-25502. PMID 11328809 DOI: 10.1074/jbc.M100395200  1
2001 Wagner RL, Huber BR, Shiau AK, Kelly A, Cunha Lima ST, Scanlan TS, Apriletti JW, Baxter JD, West BL, Fletterick RJ. Hormone selectivity in thyroid hormone receptors. Molecular Endocrinology (Baltimore, Md.). 15: 398-410. PMID 11222741 DOI: 10.1210/mend.15.3.0608  1
2001 Ribeiro RC, Feng W, Wagner RL, Costa CH, Pereira AC, Apriletti JW, Fletterick RJ, Baxter JD. Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor. The Journal of Biological Chemistry. 276: 14987-95. PMID 11145963 DOI: 10.1074/jbc.M010195200  1
2001 Kapila Y, Doan D, Tafolla E, Fletterick R. Biphasic effects of leukemia inhibitory factor on osteoblastic differentiation Journal of Cellular Biochemistry. 81: 63-70. DOI: 10.1002/jcb.1086  1
2000 Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure (London, England : 1993). 8: 831-40. PMID 10997902 DOI: 10.1016/S0969-2126(00)00173-8  1
2000 Waugh SM, Harris JL, Fletterick R, Craik CS. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity Nature Structural Biology. 7: 762-765. PMID 10966646 DOI: 10.1038/78992  1
2000 Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. Journal of Molecular Biology. 299: 993-1003. PMID 10843853 DOI: 10.1006/jmbi.2000.3812  1
2000 Vale RD, Case R, Sablin E, Hart C, Fletterick R. Searching for kinesin's mechanical amplifier. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355: 449-57. PMID 10836498 DOI: 10.1098/rstb.2000.0586  1
1999 Weatherman RV, Fletterick RJ, Scanlan TS. Nuclear-receptor ligands and ligand-binding domains. Annual Review of Biochemistry. 68: 559-81. PMID 10872460 DOI: 10.1146/annurev.biochem.68.1.559  1
1999 Borngräber S, Browner M, Gillmor S, Gerth C, Anton M, Fletterick R, Kühn H. Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity Journal of Biological Chemistry. 274: 37345-37350. PMID 10601303 DOI: 10.1074/jbc.274.52.37345  1
1999 Han Y, Sablin EP, Nogales E, Fletterick RJ, Downing KH. Visualizing a new binding site of ncd-motor domain on tubulin. Journal of Structural Biology. 128: 26-33. PMID 10600555 DOI: 10.1006/jsbi.1999.4162  1
1999 Kanyo ZF, Pan KM, Williamson RA, Burton DR, Prusiner SB, Fletterick RJ, Cohen FE. Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change. Journal of Molecular Biology. 293: 855-63. PMID 10543972 DOI: 10.1006/jmbi.1999.3193  1
1999 Norman AW, Adams D, Collins ED, Okamura WH, Fletterick RJ. Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3). Journal of Cellular Biochemistry. 74: 323-33. PMID 10412035 DOI: 10.1002/(SICI)1097-4644(19990901)74:3<323::AID-JCB2>3.0.CO;2-V  1
1999 Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, Earnest TN, Fletterick RJ, Hwang PK. Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature. 399: 371-5. PMID 10360576 DOI: 10.1038/20708  1
1998 Kull FJ, Vale RD, Fletterick RJ. The case for a common ancestor: kinesin and myosin motor proteins and G proteins. Journal of Muscle Research and Cell Motility. 19: 877-86. PMID 10047987 DOI: 10.1023/A:1005489907021  1
1998 Butte MJ, Hwang PK, Mobley WC, Fletterick RJ. Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 37: 16846-52. PMID 9836577 DOI: 10.1021/bi981254o  1
1998 Apriletti JW, Ribeiro RC, Wagner RL, Feng W, Webb P, Kushner PJ, West BL, Nilsson S, Scanlan TS, Fletterick RJ, Baxter JD. Molecular and structural biology of thyroid hormone receptors. Clinical and Experimental Pharmacology & Physiology. Supplement. 25: S2-11. PMID 9809185  1
1998 Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR. Structure and specificity of nuclear receptor-coactivator interactions. Genes & Development. 12: 3343-56. PMID 9808622  1
1998 Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ. Direction determination in the minus-end-directed kinesin motor ncd. Nature. 395: 813-6. PMID 9796817 DOI: 10.1038/27463  1
1998 Focia PJ, Craig SP, Nieves-Alicea R, Fletterick RJ, Eakin AE. A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi. Biochemistry. 37: 15066-75. PMID 9790669 DOI: 10.1021/bi981052s  1
1998 Ribeiro RC, Apriletti JW, Wagner RL, West BL, Feng W, Huber R, Kushner PJ, Nilsson S, Scanlan T, Fletterick RJ, Schaufele F, Baxter JD. Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies. Recent Progress in Hormone Research. 53: 351-92; discussion 3. PMID 9769715  1
1998 Buchbinder JL, Stephenson RC, Scanlan TS, Fletterick RJ. A comparison of the crystallographic structures of two catalytic antibodies with esterase activity. Journal of Molecular Biology. 282: 1033-41. PMID 9753552 DOI: 10.1006/jmbi.1998.2025  1
1998 Collingwood TN, Wagner R, Matthews CH, Clifton-Bligh RJ, Gurnell M, Rajanayagam O, Agostini M, Fletterick RJ, Beck-Peccoz P, Reinhardt W, Binder G, Ranke MB, Hermus A, Hesch RD, Lazarus J, et al. A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone. The Embo Journal. 17: 4760-70. PMID 9707435 DOI: 10.1093/emboj/17.16.4760  1
1998 Kull FJ, Fletterick RJ. Is the tubulin/FtsZ fold related to the G-protein fold? Trends in Cell Biology. 8: 306-7. PMID 9704406 DOI: 10.1016/S0962-8924(98)01319-1  1
1998 Ribeiro RC, Apriletti JW, Wagner RL, Feng W, Kushner PJ, Nilsson S, Scanlan TS, West BL, Fletterick RJ, Baxter JD. X-ray crystallographic and functional studies of thyroid hormone receptor. The Journal of Steroid Biochemistry and Molecular Biology. 65: 133-41. PMID 9699866 DOI: 10.1016/S0960-0760(98)00029-6  1
1998 Buchbinder JL, Stephenson RC, Dresser MJ, Pitera JW, Scanlan TS, Fletterick RJ. Biochemical Characterization and Crystallographic Structure of an Escherichia coli Protein from the Phosphotriesterase Gene Family. Biochemistry. 37: 10860. PMID 9692977 DOI: 10.1021/bi985043v  0.6
1998 Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS. Ecotin: a serine protease inhibitor with two distinct and interacting binding sites. Journal of Molecular Biology. 279: 945-57. PMID 9642073 DOI: 10.1006/jmbi.1998.1748  1
1998 Feng W, Ribeiro RC, Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ, West BL. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science (New York, N.Y.). 280: 1747-9. PMID 9624051 DOI: 10.1126/science.280.5370.1747  1
1998 Clifton-Bligh RJ, de Zegher F, Wagner RL, Collingwood TN, Francois I, Van Helvoirt M, Fletterick RJ, Chatterjee VK. A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation. Molecular Endocrinology (Baltimore, Md.). 12: 609-21. PMID 9605924 DOI: 10.1210/mend.12.5.0113  1
1998 Somoza JR, Skillman AG, Munagala NR, Oshiro CM, Knegtel RM, Mpoke S, Fletterick RJ, Kuntz ID, Wang CC. Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan. Biochemistry. 37: 5344-8. PMID 9548915 DOI: 10.1021/bi973095z  1
1998 Buchbinder JL, Stephenson RC, Dresser MJ, Pitera JW, Scanlan TS, Fletterick RJ. Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family. Biochemistry. 37: 5096-106. PMID 9548740 DOI: 10.1021/bi971707+  1
1998 Zhang YH, Guo W, Wagner RL, Huang BL, McCabe L, Vilain E, Burris TP, Anyane-Yeboa K, Burghes AH, Chitayat D, Chudley AE, Genel M, Gertner JM, Klingensmith GJ, Levine SN, ... ... Fletterick RJ, et al. DAX1 mutations map to putative structural domains in a deduced three-dimensional model. American Journal of Human Genetics. 62: 855-64. PMID 9529340 DOI: 10.1086/301782  1
1998 Endow SA, Fletterick RJ. Reversing a 'backwards' motor Bioessays. 20: 108-112. DOI: 10.1002/(SICI)1521-1878(199802)20:2<108::AID-BIES2>3.0.CO;2-P  1
1997 Vale RD, Fletterick RJ. The design plan of kinesin motors. Annual Review of Cell and Developmental Biology. 13: 745-77. PMID 9442886 DOI: 10.1146/annurev.cellbio.13.1.745  1
1997 Lin K, Hwang PK, Fletterick RJ. Distinct phosphorylation signals converge at the catalytic center in glycogen phosphorylases. Structure (London, England : 1993). 5: 1511-23. PMID 9384566  1
1997 Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC. Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex. Biochemistry. 36: 10666-74. PMID 9271497 DOI: 10.1021/bi9708850  1
1997 Gillmor SA, Craik CS, Fletterick RJ. Structural determinants of specificity in the cysteine protease cruzain. Protein Science : a Publication of the Protein Society. 6: 1603-11. PMID 9260273 DOI: 10.1002/pro.5560060801  1
1997 Sosa H, Dias DP, Hoenger A, Whittaker M, Wilson-Kubalek E, Sablin E, Fletterick RJ, Vale RD, Milligan RA. A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell. 90: 217-24. PMID 9244296 DOI: 10.1016/S0092-8674(00)80330-X  1
1997 Buchbinder JL, Luong CB, Browner MF, Fletterick RJ. Partial activation of muscle phosphorylase by replacement of serine 14 with acidic residues at the site of regulatory phosphorylation. Biochemistry. 36: 8039-44. PMID 9201951 DOI: 10.1021/bi9704820  1
1997 Craig SP, Focia PJ, Fletterick RJ. Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site. Biochimica Et Biophysica Acta. 1339: 1-3. PMID 9165092 DOI: 10.1016/S0167-4838(97)00037-X  1
1997 Tsu CA, Perona JJ, Fletterick RJ, Craik CS. Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1. Biochemistry. 36: 5393-401. PMID 9154921 DOI: 10.1021/bi961753u  1
1997 Perona JJ, Tsu CA, Craik CS, Fletterick RJ. Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix. Biochemistry. 36: 5381-92. PMID 9154920 DOI: 10.1021/bi9617522  1
1997 Collingwood TN, Rajanayagam O, Adams M, Wagner R, Cavaillès V, Kalkhoven E, Matthews C, Nystrom E, Stenlof K, Lindstedt G, Tisell L, Fletterick RJ, Parker MG, Chatterjee VK. A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators. Proceedings of the National Academy of Sciences of the United States of America. 94: 248-53. PMID 8990194 DOI: 10.1073/pnas.94.1.248  1
1997 Eakin AE, Focia PJ, Nieves-Alicea R, Craig SP, Fletterick RJ. The crystal structure of the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) from trypanosoma cruzi Protein Engineering. 10: 46.  1
1996 Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, et al. Structure-based design of parasitic protease inhibitors. Bioorganic & Medicinal Chemistry. 4: 1421-7. PMID 8894100 DOI: 10.1016/0968-0896(96)00136-8  1
1996 Buchbinder JL, Fletterick RJ. Role of the active site gate of glycogen phosphorylase in allosteric inhibition and substrate binding. The Journal of Biological Chemistry. 271: 22305-9. PMID 8798388  0.6
1996 Rath VL, Lin K, Hwang PK, Fletterick RJ. The evolution of an allosteric site in phosphorylase. Structure (London, England : 1993). 4: 463-73. PMID 8740368  1
1996 Lin K, Rath VL, Dai SC, Fletterick RJ, Hwang PK. A protein phosphorylation switch at the conserved allosteric site in GP. Science (New York, N.Y.). 273: 1539-42. PMID 8703213  1
1996 Somoza JR, Chin MS, Focia PJ, Wang CC, Fletterick RJ. Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus. Biochemistry. 35: 7032-40. PMID 8679528 DOI: 10.1021/bi953072p  1
1996 Brinen LS, Willett WS, Craik CS, Fletterick RJ. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Biochemistry. 35: 5999-6009. PMID 8634241 DOI: 10.1021/bi9530200  1
1996 Willett WS, Brinen LS, Fletterick RJ, Craik CS. Delocalizing trypsin specificity with metal activation. Biochemistry. 35: 5992-8. PMID 8634240 DOI: 10.1021/bi9530191  1
1996 Mehlhorn I, Groth D, Stöckel J, Moffat B, Reilly D, Yansura D, Willett WS, Baldwin M, Fletterick R, Cohen FE, Vandlen R, Henner D, Prusiner SB. High-level expression and characterization of a purified 142-residue polypeptide of the prion protein. Biochemistry. 35: 5528-37. PMID 8611544 DOI: 10.1021/bi952965e  0.36
1996 Sablin EP, Kull FJ, Cooke R, Vale RD, Fletterick RJ. Crystal structure of the motor domain of the kinesin-related motor ncd. Nature. 380: 555-9. PMID 8606780 DOI: 10.1038/380555a0  1
1996 Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 380: 550-5. PMID 8606779 DOI: 10.1038/380550a0  1
1995 Guo J, Huang W, Zhou GW, Fletterick RJ, Scanlan TS. Mechanistically different catalytic antibodies obtained from immunization with a single transition-state analog. Proceedings of the National Academy of Sciences of the United States of America. 92: 1694-8. PMID 7878042 DOI: 10.1073/pnas.92.5.1694  1
1995 Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS. Engineered metal regulation of trypsin specificity Biochemistry. 34: 2172-2180. PMID 7857928  1
1995 Perona JJ, Hedstrom L, Rutter WJ, Fletterick RJ. Structural origins of substrate discrimination in trypsin and chymotrypsin. Biochemistry. 34: 1489-99. PMID 7849008  1
1995 Crerar MM, Karlsson O, Fletterick RJ, Hwang PK. Chimeric muscle and brain glycogen phosphorylases define protein domains governing isozyme-specific responses to allosteric activation. The Journal of Biological Chemistry. 270: 13748-56. PMID 7775430 DOI: 10.1074/jbc.270.23.13748  1
1995 McGrath ME, Gillmor SA, Fletterick RJ. Ecotin: lessons on survival in a protease-filled world. Protein Science : a Publication of the Protein Society. 4: 141-8. PMID 7757004 DOI: 10.1002/pro.5560040201  1
1995 Buchbinder JL, Guinovart JJ, Fletterick RJ. Mutations in paired alpha-helices at the subunit interface of glycogen phosphorylase alter homotropic and heterotropic cooperativity. Biochemistry. 34: 6423-32. PMID 7756273  1
1995 Sablin EP, Fletterick RJ. Crystallization and preliminary structural studies of the ncd motor domain Proteins: Structure, Function and Genetics. 21: 68-69. PMID 7716170 DOI: 10.1002/prot.340210108  1
1995 McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. The crystal structure of cruzain: a therapeutic target for Chagas' disease. Journal of Molecular Biology. 247: 251-9. PMID 7707373 DOI: 10.1006/jmbi.1994.0137  1
1995 Buchbinder JL, Witkowski A, Smith S, Fletterick RJ. Crystallization and preliminary diffraction studies of thioesterase II from rat mammary gland Proteins: Structure, Function and Genetics. 22: 73-75. PMID 7675790 DOI: 10.1002/prot.340220111  1
1995 Ribeiro RC, Apriletti JW, West BL, Wagner RL, Fletterick RJ, Schaufele F, Baxter JD. The molecular biology of thyroid hormone action. Annals of the New York Academy of Sciences. 758: 366-89. PMID 7625705 DOI: 10.1111/j.1749-6632.1995.tb24843.x  1
1995 Hoenger A, Sablin EP, Vale RD, Fletterick RJ, Milligan RA. Three-dimensional structure of a tubulin-motor-protein complex. Nature. 376: 271-4. PMID 7617040 DOI: 10.1038/376271a0  1
1995 Lin K, Hwang PK, Fletterick RJ. Mechanism of regulation in yeast glycogen phosphorylase. The Journal of Biological Chemistry. 270: 26833-9. PMID 7592925 DOI: 10.1074/jbc.270.45.26833  1
1995 Nguyen JT, Inouye H, Baldwin MA, Fletterick RJ, Cohen FE, Prusiner SB, Kirschner DA. X-ray diffraction of scrapie prion rods and PrP peptides. Journal of Molecular Biology. 252: 412-22. PMID 7563061 DOI: 10.1006/jmbi.1995.0507  1
1995 Fletterick RJ, Bazan JF. When one and one are not two. Nature Structural Biology. 2: 721-3. PMID 7552738  1
1995 Shimizu T, Sablin E, Vale RD, Fletterick R, Pechatnikova E, Taylor EW. Expression, purification, ATPase properties, and microtubule-binding properties of the ncd motor domain Biochemistry. 34: 13259-13266. PMID 7548090  1
1995 Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ. A structural role for hormone in the thyroid hormone receptor. Nature. 378: 690-7. PMID 7501015 DOI: 10.1038/378690a0  1
1995 Gillmor SA, McGrath ME, Fletterick RJ. Ecotin: A most adaptable protease inhibitor Perspectives in Drug Discovery and Design. 2: 475-482. DOI: 10.1007/BF02172039  1
1994 McGrath ME, Erpel T, Bystroff C, Fletterick RJ. Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex. The Embo Journal. 13: 1502-7. PMID 8156987  1
1994 Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ. Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. Biochemistry. 33: 3252-9. PMID 8136360  1
1994 McGrath ME, Wagner RL, Apriletti JW, West BL, Ramalingam V, Baxter JD, Fletterick RJ. Preliminary crystallographic studies of the ligand-binding domain of the thyroid hormone receptor complexed with triiodothyronine. Journal of Molecular Biology. 237: 236-9. PMID 8126736 DOI: 10.1006/jmbi.1994.1224  1
1994 Zhou GW, Guo J, Huang W, Fletterick RJ, Scanlan TS. Crystal structure of a catalytic antibody with a serine protease active site. Science (New York, N.Y.). 265: 1059-64. PMID 8066444  1
1994 Guenot J, Fletterick RJ, Kollman PA. A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA. Protein Science : a Publication of the Protein Society. 3: 1276-85. PMID 7987223 DOI: 10.1002/pro.5560030814  1
1994 Baldwin MA, Pan KM, Nguyen J, Huang Z, Groth D, Serban A, Gasset M, Mehlhorn I, Fletterick RJ, Cohen FE. Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 343: 435-441. PMID 7913763 DOI: 10.1098/rstb.1994.0041  1
1994 Huang Z, Gabriel JM, Baldwin MA, Fletterick RJ, Prusiner SB, Cohen FE. Proposed three-dimensional structure for the cellular prion protein. Proceedings of the National Academy of Sciences of the United States of America. 91: 7139-43. PMID 7913747 DOI: 10.1073/pnas.91.15.7139  1
1994 Cohen FE, Pan KM, Huang Z, Baldwin M, Fletterick RJ, Prusiner SB. Structural clues to prion replication. Science (New York, N.Y.). 264: 530-1. PMID 7909169  1
1994 Fletterick RJ, McGrath ME. Deconvoluting serpins. Nature Structural Biology. 1: 201-3. PMID 7656041  1
1994 Rath VL, Fletterick RJ. Parallel evolution in two homologues of phosphorylase Nature Structural Biology. 1: 681-690. PMID 7634071  1
1993 Perona JJ, Tsu CA, McGrath ME, Craik CS, Fletterick RJ. Relocating a negative charge in the binding pocket of trypsin. Journal of Molecular Biology. 230: 934-49. PMID 8478942 DOI: 10.1006/jmbi.1993.1211  1
1993 Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS. Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. The Journal of Biological Chemistry. 268: 6115-8. PMID 8454586  1
1993 McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ. Structure of an engineered, metal-actuated switch in trypsin. Biochemistry. 32: 1914-9. PMID 8448149  1
1993 Gasset M, Baldwin MA, Fletterick RJ, Prusiner SB. Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity Proceedings of the National Academy of Sciences of the United States of America. 90: 1-5. PMID 8419912  1
1993 Perona JJ, Craik CS, Fletterick RJ. Locating the catalytic water molecule in serine proteases Science. 261: 620-622. PMID 8342029  1
1993 Pan KM, Baldwin M, Nguyen J, Gasset M, Serban A, Groth D, Mehlhorn I, Huang Z, Fletterick RJ, Cohen FE, Prusiner SB. Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins Proceedings of the National Academy of Sciences of the United States of America. 90: 10962-10966. PMID 7902575 DOI: 10.1073/pnas.90.23.10962  1
1993 Perona JJ, Tsu CA, Craik CS, Fletterick RJ. Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI. Journal of Molecular Biology. 230: 919-33. PMID 7683059 DOI: 10.1006/jmbi.1993.1210  1
1992 Rath VL, Hwang PK, Fletterick RJ. Purification and crystallization of glycogen phosphorylase from Saccharomyces cerevisiae Journal of Molecular Biology. 225: 1027-1034. PMID 1613787 DOI: 10.1016/0022-2836(92)90102-P  1
1992 Browner MF, Fletterick RJ. Phosphorylase: a biological transducer Trends in Biochemical Sciences. 17: 66-71. PMID 1566331 DOI: 10.1016/0968-0004(92)90504-3  1
1992 McGrath ME, Vásquez JR, Craik CS, Yang AS, Honig B, Fletterick RJ. Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214. Biochemistry. 31: 3059-64. PMID 1554694  1
1992 Erpel T, Hwang P, Craik CS, Fletterick RJ, McGrath ME. Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin. Journal of Bacteriology. 174: 1704. PMID 1537814  1
1992 Luong CB, Browner MF, Fletterick RJ, Haymore BL. Purification of glycogen phosphorylase isozymes by metal-affinity chromatography. Journal of Chromatography. 584: 77-84. PMID 1487518 DOI: 10.1016/0378-4347(92)80011-E  1
1992 Goddette DW, Paech C, Yang SS, Mielenz JR, Bystroff C, Wilke ME, Fletterick RJ. The crystal structure of the Bacillus lentus alkaline protease, subtilisin BL, at 1.4 A resolution. Journal of Molecular Biology. 228: 580-95. PMID 1453465 DOI: 10.1016/0022-2836(92)90843-9  1
1992 Browner MF, Fauman EB, Fletterick RJ. Tracking conformational states in allosteric transitions of phosphorylase Biochemistry. 31: 11297-11304. PMID 1445867  1
1992 Browner MF, Hwang PK, Fletterick RJ. Cooperative binding is not required for activation of muscle phosphorylase Biochemistry. 31: 11291-11296. PMID 1445866 DOI: 10.1021/bi00161a005  1
1992 Gasset M, Baldwin MA, Lloyd DH, Gabriel JM, Holtzman DM, Cohen F, Fletterick R, Prusiner SB. Predicted α-helical regions of the prion protein when synthesized as peptides form amyloid Proceedings of the National Academy of Sciences of the United States of America. 89: 10940-10944. PMID 1438300 DOI: 10.1073/pnas.89.22.10940  1
1992 Higaki JN, Fletterick RJ, Craik CS. Engineered metalloregulation in enzymes Trends in Biochemical Sciences. 17: 100-104. PMID 1329276 DOI: 10.1016/0968-0004(92)90245-5  1
1992 Phillips MA, Fletterick RJ. Proteases Current Opinion in Structural Biology. 2: 713-720. DOI: 10.1016/0959-440X(92)90206-M  1
1992 Corey DR, McGrath ME, Vásquez JR, Fletterick RJ, Craik CS. An alternate geometry for the catalytic triad of serine proteases Journal of the American Chemical Society. 114: 4905-4907.  1
1991 Wilke ME, Higaki JN, Craik CS, Fletterick RJ. Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis. Journal of Molecular Biology. 219: 525-32. PMID 2051486 DOI: 10.1016/0022-2836(91)90191-8  1
1991 McGrath ME, Hines WM, Sakanari JA, Fletterick RJ, Craik CS. The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli. The Journal of Biological Chemistry. 266: 6620-5. PMID 2007606  1
1991 Sprang SR, Withers SG, Goldsmith EJ, Fletterick RJ, Madsen NB. Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate. Science (New York, N.Y.). 254: 1367-71. PMID 1962195  1
1991 McGrath ME, Erpel T, Browner MF, Fletterick RJ. Expression of the protease inhibitor ecotin and its co-crystallization with trypsin. Journal of Molecular Biology. 222: 139-42. PMID 1960717 DOI: 10.1016/0022-2836(91)90199-G  1
1991 Wilke ME, Higaki JN, Craik CS, Fletterick RJ. Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases. Journal of Molecular Biology. 219: 511-23. PMID 1904942 DOI: 10.1016/0022-2836(91)90190-H  1
1991 Coats WS, Browner MF, Fletterick RJ, Newgard CB. An engineered liver glycogen phosphorylase with AMP allosteric activation Journal of Biological Chemistry. 266: 16113-16119. PMID 1874749  1
1991 Browner MF, Rasor P, Tugendreich S, Fletterick RJ. Temperature-sensitive production of rabbit muscle glycogen phosphorylase in Escherichia coli Protein Engineering. 4: 351-357. PMID 1857717  1
1991 Gregoret LM, Rader SD, Fletterick RJ, Cohen FE. Hydrogen bonds involving sulfur atoms in proteins Proteins: Structure, Function and Genetics. 9: 99-107. PMID 1755867  1
1990 Sloane DL, Browner MF, Dauter Z, Wilson K, Fletterick RJ, Sigal E. Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes Biochemical and Biophysical Research Communications. 173: 507-513. PMID 2260964 DOI: 10.1016/S0006-291X(05)80063-4  1
1990 Chambers TJ, Weir RC, Grakoui A, Mccourt DW, Bazan JF, Fletterick RJ, Rice CM. Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein Proceedings of the National Academy of Sciences of the United States of America. 87: 8898-8902. PMID 2147282  1
1990 Higaki JN, Haymore BL, Chen S, Fletterick RJ, Craik CS. Regulation of serine protease activity by an engineered metal switch. Biochemistry. 29: 8582-6. PMID 2125468  1
1989 Goldsmith EJ, Sprang SR, Hamlin R, Xuong NH, Fletterick RJ. Domain separation in the activation of glycogen phosphorylase a. Science (New York, N.Y.). 245: 528-32. PMID 2756432  1
1989 Bazan JF, Fletterick RJ. Comparative analysis of viral cysteine protease structural models Febs Letters. 249: 5-7. PMID 2721688 DOI: 10.1016/0014-5793(89)80003-1  1
1989 Soman K, Yang AS, Honig B, Fletterick R. Electrical potentials in trypsin isozymes Biochemistry. 28: 9918-9926. PMID 2695163 DOI: 10.1021/bi00452a007  1
1989 Newgard CB, Hwang PK, Fletterick RJ. The family of glycogen phosphorylases: structure and function Critical Reviews in Biochemistry and Molecular Biology. 24: 69-99. PMID 2667896  1
1989 Hwang PK, Tugendreich S, Fletterick RJ. Molecular analysis of GPH1, the gene encoding glycogen phosphorylase in Saccharomyces cerevisiae Molecular and Cellular Biology. 9: 1659-1666. PMID 2657401  1
1989 McGrath ME, Fletterick RJ, Craik CS. Rapid preparation of proteins for crystallization trials. Biotechniques. 7: 246-7. PMID 2631770  1
1989 McGrath ME, Wilke ME, Higaki JN, Craik CS, Fletterick RJ. Crystal structures of two engineered thiol trypsins. Biochemistry. 28: 9264-70. PMID 2611228 DOI: 10.1021/bi00450a005  1
1989 Fernando Bazan J, Fletterick RJ, Pilkis SJ. Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Proceedings of the National Academy of Sciences of the United States of America. 86: 9642-9646. PMID 2557623 DOI: 10.1073/pnas.86.24.9642  1
1989 Bazan JF, Fletterick RJ. Detection of a trypsin-like serine protease domain in flaviviruses and pestviruses Virology. 171: 637-639. PMID 2548336 DOI: 10.1016/0042-6822(89)90639-9  1
1989 Zhang W, Browner MF, Fletterick RJ, DePaoli-Roach AA, Roach PJ. Primary structure of rabbit skeletal muscle glycogen synthase deduced from cDNA clones Faseb Journal. 3: 2532-2536. PMID 2509275  1
1989 Browner MF, Nakano K, Bang AG, Fletterick RJ. Human muscle glycogen synthase cDNA sequence: A negatively charged protein with an asymmetric charge distribution Proceedings of the National Academy of Sciences of the United States of America. 86: 1443-1447. PMID 2493642  1
1989 Dougherty WG, Parks TD, Cary SM, Bazan JF, Fletterick RJ. Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase. Virology. 172: 302-10. PMID 2475971 DOI: 10.1016/0042-6822(89)90132-3  1
1989 Goldsmith EJ, Sprang SR, Fletterick RJ. Alternative binding modes for maltopentaose in the activation site of glycogen phosphorylase a Transactions of the American Crystallographic Association. 25: 87-104.  1
1988 Newgard CB, Littman DR, Van Genderen C, Smith M, Fletterick RJ. Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes Journal of Biological Chemistry. 263: 3850-3857. PMID 3346228  1
1988 Sprang SR, Acharya KR, Goldsmith EJ, Stuart DI, Varvill K, Fletterick RJ, Madsen NB, Johnson LN. Structural changes in glycogen phosphorylase induced by phosphorylation. Nature. 336: 215-21. PMID 3194008 DOI: 10.1038/336215a0  1
1988 Bazan JF, Fletterick RJ. Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: Structural and functional implications Proceedings of the National Academy of Sciences of the United States of America. 85: 7872-7876. PMID 3186696  1
1988 Sprang SR, Fletterick RJ, Gráf L, Rutter WJ, Craik CS. Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants. Critical Reviews in Biotechnology. 8: 225-36. PMID 3063392 DOI: 10.3109/07388558809147559  1
1987 Rath VL, Newgard CB, Sprang SR, Goldsmith EJ, Fletterick RJ. Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. Proteins. 2: 225-35. PMID 3447179 DOI: 10.1002/prot.340020307  0.4
1987 Pastuszyn A, Noland BJ, Bazan JF, Fletterick RJ, Scallen TJ. Primary sequence and structural analysis of sterol carrier protein 2 from rat liver: homology with immunoglobulins Journal of Biological Chemistry. 262: 13219-13227. PMID 3115977  1
1987 Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS. The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science (New York, N.Y.). 237: 905-9. PMID 3112942 DOI: 10.1126/science.3112942  1
1987 Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin. Biochemistry. 26: 2616-23. PMID 3111531  1
1987 Braun MJ, George DG, Bazan JF, Fletterick RJ, Gonda MA, Prusiner SB. The burden of proof in linking AIDS to scrapie [6] Nature. 330: 525-526. PMID 2891035  1
1987 Bazan JF, Fletterick RJ, Prusiner SB. AIDS virus and scrapie protein genes Nature. 325: 581.  1
1986 Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. Turn prediction in proteins using a pattern-matching approach Biochemistry. 25: 266-275. PMID 3754149 DOI: 10.1021/bi00349a037  1
1986 Fletterick RJ, Burke JA, Hwang PK, Nakano K, Newgard CB. Structural relationships in glycogen phosphorylases. Annals of the New York Academy of Sciences. 478: 220-32. PMID 3541750 DOI: 10.1111/j.1749-6632.1986.tb15533.x  0.36
1985 Hwang PK, See YP, Vincentini AM, Powers MA, Fletterick RJ, Crerar MM. Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs European Journal of Biochemistry. 152: 267-274. PMID 3840433 DOI: 10.1111/j.1432-1033.1985.tb09193.x  1
1985 Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. Redesigning trypsin: Alteration of substrate specificity Science. 228: 291-297. PMID 3838593 DOI: 10.1126/science.3838593  1
1984 Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW. High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science (New York, N.Y.). 225: 57-9. PMID 6587566 DOI: 10.1126/science.6587566  1
1984 Hwang P, Stern M, Fletterick RJ. Purification and crystallization of bovine liver phosphorylase Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 791: 252-258. PMID 6509068 DOI: 10.1016/0167-4838(84)90016-5  1
1983 Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. Secondary structure assignment for α/β proteins by a combinatorial approach Biochemistry. 22: 4894-4904. PMID 6639935 DOI: 10.1021/bi00290a005  1
1983 Madsen NB, Shechosky S, Fletterick RJ. Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site. Biochemistry. 22: 4460-5. PMID 6414512 DOI: 10.1021/bi00288a017  1
1983 Craik CS, Rutter WJ, Fletterick R. Splice junctions: Association with variation in protein structure Science. 220: 1125-1129. PMID 6344214 DOI: 10.1126/science.6344214  1
1982 Withers SG, Madsen NB, Sprang SR, Fletterick RJ. Catalytic site of glycogen phosphorylase: structural changes during activation and mechanistic implications. Biochemistry. 21: 5372-82. PMID 7171564  1
1982 Sprang S, Fletterick R, Stern M, Yang D, Madsen N, Sturtevant J. Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase alpha Biochemistry. 21: 2036-2048. PMID 7093228 DOI: 10.1021/bi00538a010  1
1982 Sprang SR, Goldsmith EJ, Fletterick RJ, Withers SG, Madsen NB. Catalytic site of glycogen phosphorylase: structure of the T state and specificity for alpha-D-glucose. Biochemistry. 21: 5364-71. PMID 6816272  1
1982 Fletterick RJ, Sprang SR. Glycogen phosphorylase structures and function Accounts of Chemical Research. 15: 361-369.  1
1981 Kasvinsky PJ, Fletterick RJ, Madsen NB. Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes. Canadian Journal of Biochemistry. 59: 387-95. PMID 6794883 DOI: 10.1139/o81-054  1
1979 Fletterick RJ, Sprang S, Madsen NB. Analysis of the surface topography of glycogen phosphorylase a: implications for metabolic interconversion and regulatory mechanisms. Canadian Journal of Biochemistry. 57: 789-97. PMID 476522 DOI: 10.1139/o79-098  1
1979 Withers SG, Yang DS, Madsen NB, Fletterick RJ. A systematic approach to isomorphous replacement using a series of simple charged mercurials. Biochemical and Biophysical Research Communications. 86: 1044-50. PMID 435308 DOI: 10.1016/0006-291X(79)90222-5  1
1977 Li EC, Fletterick RJ, Sygusch J, Madsen NB. An essential arginine residue in the active-site pocket of glycogen phosporylase. Canadian Journal of Biochemistry. 55: 465-73. PMID 870152 DOI: 10.1139/o77-065  1
1977 Steitz TA, Anderson WF, Fletterick RJ, Anderson CM. High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site. The Journal of Biological Chemistry. 252: 4494-500. PMID 326777  1
1977 Sygusch J, Madsen NB, Kasvinsky PJ, Fletterick RJ. Location of pyridoxal phosphate in glycogen phosphorylase a. Proceedings of the National Academy of Sciences of the United States of America. 74: 4757-61. PMID 270710 DOI: 10.1073/pnas.74.11.4757  1
1977 Fletterick RJ, Madsen NB. X-rays reveal phosphorylase architecture Trends in Biochemical Sciences. 2: 145-148. DOI: 10.1016/0968-0004(77)90361-9  1
1976 Steitz TA, Fletterick RJ, Anderson WF, Anderson CM. High resolution x-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits. Journal of Molecular Biology. 104: 197-22. PMID 785010 DOI: 10.1016/0022-2836(76)90009-7  1
1976 Fletterick RJ, Steitz TA. The combination of independent phase information obtained from separate protein structure determinations of yeast hexokinase Acta Crystallographica Section A. 32: 125-132. DOI: 10.1107/S0567739476000235  1
1976 Fletterick RJ, Sygusch J, Murray N, Madsen NB, Johnson LN. Low-resolution structure of the glycogen phosphorylase a monomer and comparison with phosphorylase b Journal of Molecular Biology. 103: 1-13. DOI: 10.1016/0022-2836(76)90048-6  1
1975 Fletterick RJ, Bates DJ, Steitz TA. The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 72: 38-42. PMID 164023 DOI: 10.1073/pnas.72.1.38  1
1974 Anderson WF, Fletterick RJ, Steitz TA. Structure of yeast hexokinase. 3. Low resolution structure of a second crystal form showing a different quaternary structure, heterologous interaction of subunits and substrate binding. Journal of Molecular Biology. 86: 261-9. PMID 4370398 DOI: 10.1016/0022-2836(74)90017-5  1
1974 STEITZ TA, FLETTERICK RJ, ANDERSON WF, BATES DJ. The Structure of Yeast Hexokinase and its Complexes with Substrates Biochemical Society Transactions. 2: 52-54. DOI: 10.1042/bst0020052c  1
1973 Steitz TA, Fletterick RJ, Hwang KJ. Structure of yeast hexokinase. II. A 6 angstrom resolution electron density map showing molecular shape and heterologous interaction of subunits. Journal of Molecular Biology. 78: 551-61. PMID 4585329 DOI: 10.1016/0022-2836(73)90475-0  1
1971 Fletterick RJ, Tsai CC, Hughes RE. The crystal and molecular structure of L-alanyl-L-alanine. The Journal of Physical Chemistry. 75: 918-22. PMID 5552704  0.4
1971 Fletterick RJ, Tsai C, Hughes RE. The crystal and molecular structure of L-alanyl-L-alanine. The Journal of Physical Chemistry. 75: 918-22. PMID 5135343  1
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