Andrea G. Cochran - Publications

1996- Genentech Inc., Oceanside, CA, United States 
proteins, biophysics, biochemistry

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wang S, Tsui V, Crawford TD, Audia JE, Burdick DJ, Beresini MH, Côté A, Cummings R, Duplessis M, Flynn EM, Hewitt MC, Huang HR, Jayaram H, Jiang Y, Joshi S, ... ... Cochran AG, et al. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. Journal of Medicinal Chemistry. PMID 30289257 DOI: 10.1021/acs.jmedchem.8b01225  1
2017 Oppikofer M, Sagolla M, Haley B, Zhang HM, Kummerfeld SK, Sudhamsu J, Flynn EM, Bai T, Zhang J, Ciferri C, Cochran AG. Non-canonical reader modules of BAZ1A promote recovery from DNA damage. Nature Communications. 8: 862. PMID 29021563 DOI: 10.1038/s41467-017-00866-0  1
2017 Oppikofer M, Bai T, Gan Y, Haley B, Liu P, Sandoval W, Ciferri C, Cochran AG. Expansion of the ISWI chromatin remodeler family with new active complexes. Embo Reports. PMID 28801535 DOI: 10.15252/embr.201744011  1
2017 Crawford TD, Audia JE, Bellon S, Burdick DJ, Bommi-Reddy A, Côté A, Cummings RT, Duplessis M, Flynn EM, Hewitt M, Huang HR, Jayaram H, Jiang Y, Joshi S, Kiefer JR, ... ... Cochran AG, et al. GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). Acs Medicinal Chemistry Letters. 8: 737-741. PMID 28740608 DOI: 10.1021/acsmedchemlett.7b00132  1
2017 Crawford TD, Vartanian S, Côté A, Bellon S, Duplessis M, Flynn EM, Hewitt M, Huang HR, Kiefer JR, Murray J, Nasveschuk CG, Pardo E, Romero FA, Sandy P, Tang Y, ... ... Cochran AG, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorganic & Medicinal Chemistry Letters. PMID 28606761 DOI: 10.1016/j.bmcl.2017.05.063  1
2016 Crawford TD, Romero FA, Lai KW, Tsui V, Taylor AM, de Leon Boenig G, Noland CL, Murray J, Ly J, Choo EF, Hunsaker TL, Chan EW, Merchant M, Kharbanda S, Gascoigne KE, ... ... Cochran AG, et al. Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. Journal of Medicinal Chemistry. PMID 27682507 DOI: 10.1021/acs.jmedchem.6b01022  1
2016 Crawford TD, Tsui V, Flynn EM, Wang S, Taylor AM, Côté A, Audia JE, Beresini MH, Burdick DJ, Cummings RT, Dakin LA, Duplessis M, Good AC, Hewitt MC, Huang HR, ... ... Cochran AG, et al. Diving into the water: Inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains. Journal of Medicinal Chemistry. PMID 27219867 DOI: 10.1021/acs.jmedchem.6b00264  1
2016 Vinogradova M, Gehling VS, Gustafson A, Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W, Busby J, Flynn EM, Lan F, Kim HJ, Odate S, ... Cochran AG, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nature Chemical Biology. PMID 27214401 DOI: 10.1038/nchembio.2085  1
2016 Taylor AM, Côté A, Hewitt MC, Pastor R, Leblanc Y, Nasveschuk CG, Romero FA, Crawford TD, Cantone N, Jayaram H, Setser J, Murray J, Beresini MH, de Leon Boenig G, Chen Z, ... ... Cochran AG, et al. Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Medicinal Chemistry Letters. 7: 531-536. PMID 27190605 DOI: 10.1021/acsmedchemlett.6b00075  1
2016 Ghosh S, Taylor A, Chin M, Huang HR, Conery AR, Mertz JA, Salmeron A, Dakle PJ, Mele D, Cote A, Jayaram H, Setser JW, Poy F, Hatzivassiliou G, DeAlmeida-Nagata D, ... ... Cochran AG, et al. Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition. The Journal of Biological Chemistry. PMID 27056325 DOI: 10.1074/jbc.M115.708560  1
2015 Flynn EM, Huang OW, Poy F, Oppikofer M, Bellon SF, Tang Y, Cochran AG. A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications. Structure (London, England : 1993). PMID 26365797 DOI: 10.1016/j.str.2015.08.004  1
2015 Taherbhoy AM, Huang OW, Cochran AG. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nature Communications. 6: 7621. PMID 26151332 DOI: 10.1038/ncomms8621  1
2015 Rutz S, Kayagaki N, Phung QT, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang OW, Cochran AG, Vasser M, Fauber BP, DeVoss J, Webster J, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 518: 417-21. PMID 25470037 DOI: 10.1038/nature13979  1
2013 Huang OW, Cochran AG. Regulation of deubiquitinase proteolytic activity. Current Opinion in Structural Biology. 23: 806-11. PMID 23962487 DOI: 10.1016/  1
2012 Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG. Phosphorylation-dependent activity of the deubiquitinase DUBA Nature Structural and Molecular Biology. 19: 171-176. PMID 22245969 DOI: 10.1038/nsmb.2206  1
2011 Bourhis E, Wang W, Tam C, Hwang J, Zhang Y, Spittler D, Huang OW, Gong Y, Estevez A, Zilberleyb I, Rouge L, Chiu C, Wu Y, Costa M, Hannoush RN, ... ... Cochran AG, et al. Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6. Structure (London, England : 1993). 19: 1433-42. PMID 21944579 DOI: 10.1016/j.str.2011.07.005  1
2011 Bentley ML, Corn JE, Dong KC, Phung Q, Cheung TK, Cochran AG. Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex. The Embo Journal. 30: 3285-97. PMID 21772249 DOI: 10.1038/emboj.2011.243  1
2010 Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. The Journal of Biological Chemistry. 285: 9172-9. PMID 20093360 DOI: 10.1074/jbc.M109.092130  1
2009 Bourhis E, Lingel A, Phung Q, Fairbrother WJ, Cochran AG. Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. Biochemistry. 48: 6783-93. PMID 19530738 DOI: 10.1021/bi900530v  1
2009 Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, ... ... Cochran AG, et al. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. Journal of Medicinal Chemistry. 52: 3300-7. PMID 19402633 DOI: 10.1021/jm9000314  1
2008 Rawson TE, Rüth M, Blackwood E, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Georges GJ, Goller B, Halladay J, Hunsaker T, Kleinheinz T, Krell HW, Li J, ... ... Cochran AG, et al. A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of Medicinal Chemistry. 51: 4465-75. PMID 18630890 DOI: 10.1021/jm800052b  1
2008 Cochran AG. Aurora A: target invalidated? Chemistry & Biology. 15: 525-6. PMID 18559262 DOI: 10.1016/j.chembiol.2008.06.002  0.01
2007 Bourhis E, Hymowitz SG, Cochran AG. The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin. The Journal of Biological Chemistry. 282: 35018-23. PMID 17881355 DOI: 10.1074/jbc.M706233200  1
2006 Li B, Russell SJ, Compaan DM, Totpal K, Marsters SA, Ashkenazi A, Cochran AG, Hymowitz SG, Sidhu SS. Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists. Journal of Molecular Biology. 361: 522-36. PMID 16859704 DOI: 10.1016/j.jmb.2006.06.042  1
2004 DeForge LE, Cochran AG, Yeh SH, Robinson BS, Billeci KL, Wong WL. Substrate capacity considerations in developing kinase assays. Assay and Drug Development Technologies. 2: 131-40. PMID 15165509 DOI: 10.1089/154065804323056477  0.16
2004 Kotz JD, Bond CJ, Cochran AG. Phage-display as a tool for quantifying protein stability determinants. European Journal of Biochemistry / Febs. 271: 1623-9. PMID 15096201 DOI: 10.1111/j.1432-1033.2004.04076.x  0.04
2003 Gordon NC, Pan B, Hymowitz SG, Yin J, Kelley RF, Cochran AG, Yan M, Dixit VM, Fairbrother WJ, Starovasnik MA. BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site. Biochemistry. 42: 5977-83. PMID 12755599 DOI: 10.1021/bi034017g  1
2003 Blandl T, Cochran AG, Skelton NJ. Turn stability in beta-hairpin peptides: Investigation of peptides containing 3:5 type I G1 bulge turns. Protein Science : a Publication of the Protein Society. 12: 237-47. PMID 12538887 DOI: 10.1110/ps.0228603  1
2003 Russell SJ, Blandl T, Skelton NJ, Cochran AG. Stability of cyclic beta-hairpins: asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair. Journal of the American Chemical Society. 125: 388-95. PMID 12517150 DOI: 10.1021/ja028075l  1
2002 Sia SK, Carr PA, Cochran AG, Malashkevich VN, Kim PS. Short constrained peptides that inhibit HIV-1 entry. Proceedings of the National Academy of Sciences of the United States of America. 99: 14664-9. PMID 12417739 DOI: 10.1073/pnas.232566599  1
2002 Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 17: 515-24. PMID 12387744 DOI: 10.1016/S1074-7613(02)00425-9  1
2002 Distefano MD, Zhong A, Cochran AG. Quantifying beta-sheet stability by phage display. Journal of Molecular Biology. 322: 179-88. PMID 12215423 DOI: 10.1016/S0022-2836(02)00738-6  1
2002 Skelton NJ, Russell S, de Sauvage F, Cochran AG. Amino acid determinants of beta-hairpin conformation in erythropoeitin receptor agonist peptides derived from a phage display library. Journal of Molecular Biology. 316: 1111-25. PMID 11884148 DOI: 10.1006/jmbi.2002.5410  1
2002 Pan B, Li B, Russell SJ, Tom JY, Cochran AG, Fairbrother WJ. Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor. Journal of Molecular Biology. 316: 769-87. PMID 11866530 DOI: 10.1006/jmbi.2001.5370  1
1998 Singh M, Berger B, Kim PS, Berger JM, Cochran AG. Computational learning reveals coiled coil-like motifs in histidine kinase linker domains. Proceedings of the National Academy of Sciences of the United States of America. 95: 2738-43. PMID 9501159 DOI: 10.1073/pnas.95.6.2738  1
1996 Cochran AG, Kim PS. Imitation of Escherichia coli aspartate receptor signaling in engineered dimers of the cytoplasmic domain Science. 271: 1113-1116. PMID 8599087  1
1990 Cochran AG, Schultz PG. Antibody-catalyzed porphyrin metallation. Science (New York, N.Y.). 249: 781-3. PMID 2389144 DOI: 10.1126/science.2389144  0.52
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