Frederick Alt, PhD - Publications

Affiliations: 
Immunology Harvard University, Cambridge, MA, United States 
Area:
DNA repair, immunology, lymphoma
Website:
http://www.childrenshospital.org/cfapps/research/data_admin/Site143/mainpageS143P0.html

362 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhang Y, Zhang X, Ba Z, Liang Z, Dring EW, Hu H, Lou J, Kyritsis N, Zurita J, Shamim MS, Presser Aiden A, Lieberman Aiden E, Alt FW. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. PMID 31511698 DOI: 10.1038/s41586-019-1547-y  0.44
2018 Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, ... ... Alt FW, et al. Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors. Nature Communications. 9: 4760. PMID 30420702 DOI: 10.1038/s41467-018-06925-4  0.44
2018 Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. PMID 30305734 DOI: 10.1038/s41586-018-0586-0  1
2018 Lin SG, Ba Z, Alt FW, Zhang Y. RAG Chromatin Scanning During V(D)J Recombination and Chromatin Loop Extrusion are Related Processes. Advances in Immunology. 139: 93-135. PMID 30249335 DOI: 10.1016/bs.ai.2018.07.001  0.44
2018 Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R, Alt FW, et al. Parp3 promotes long-range end joining in murine cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30213852 DOI: 10.1073/pnas.1801591115  0.68
2018 Alt FW, Schwer B. DNA double-strand breaks as drivers of neural genomic change, function, and disease. Dna Repair. PMID 30195640 DOI: 10.1016/j.dnarep.2018.08.019  1
2018 Tian M, Alt FW. Guiding a mutator in antibody diversification. Cell Research. PMID 30171189 DOI: 10.1038/s41422-018-0085-8  0.44
2018 Duan H, Chen X, Boyington JC, Cheng C, Zhang Y, Jafari AJ, Stephens T, Tsybovsky Y, Kalyuzhniy O, Zhao P, Menis S, Nason MC, Normandin E, Mukhamedova M, DeKosky BJ, ... ... Alt FW, et al. Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies. Immunity. PMID 30076101 DOI: 10.1016/j.immuni.2018.07.005  0.44
2018 Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S. Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 30072430 DOI: 10.1073/pnas.1808490115  1
2018 Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H. DNA melting initiates the RAG catalytic pathway. Nature Structural & Molecular Biology. PMID 30061602 DOI: 10.1038/s41594-018-0098-5  0.44
2018 Jain S, Ba Z, Zhang Y, Dai HQ, Alt FW. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning. Cell. PMID 29804837 DOI: 10.1016/j.cell.2018.04.035  0.44
2018 Wei PC, Lee CS, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW. Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432181 DOI: 10.1073/pnas.1719907115  1
2018 Panchakshari RA, Zhang X, Kumar V, Du Z, Wei PC, Kao J, Dong J, Alt FW. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311308 DOI: 10.1073/pnas.1719988115  0.68
2017 Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Upadhyayula S, Gutierrez-Martinez P, Ebina W, Fasth A, Kirchhausen T, Talkowski ME, Agarwal S, Alt FW, Rossi DJ. Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. Nature Biomedical Engineering. 1: 878-888. PMID 31015609 DOI: 10.1038/s41551-017-0145-2  0.68
2017 Willis NA, Frock RL, Menghi F, Duffey EE, Panday A, Camacho V, Hasty EP, Liu ET, Alt FW, Scully R. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature. PMID 29168504 DOI: 10.1038/nature24477  0.68
2017 Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158395 DOI: 10.1073/pnas.1701366114  0.68
2017 Xing M, Bjørås M, Daniel JA, Alt FW, Oksenych V. Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70. Dna Repair. 57: 133-138. PMID 28759779 DOI: 10.1016/j.dnarep.2017.07.008  0.48
2017 Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW, Wu H. AID Recognizes Structured DNA for Class Switch Recombination. Molecular Cell. PMID 28757211 DOI: 10.1016/j.molcel.2017.06.034  0.44
2017 Hwang JK, Wang C, Du Z, Meyers RM, Kepler TB, Neuberg D, Kwong PD, Mascola JR, Joyce MG, Bonsignori M, Haynes BF, Yeap LS, Alt FW. Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 28747530 DOI: 10.1073/pnas.1709203114  0.56
2017 Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, ... ... Alt FW, et al. Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells. Nature. PMID 28199309 DOI: 10.1038/nature21406  0.6
2017 Verkoczy L, Alt FW, Tian M. Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies. Immunological Reviews. 275: 89-107. PMID 28133799 DOI: 10.1111/imr.12505  0.44
2016 Chen L, Zhao L, Alt FW, Krangel MS. An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments. Journal of Immunology (Baltimore, Md. : 1950). PMID 27613698 DOI: 10.4049/jimmunol.1601124  0.44
2016 Tian M, Cheng C, Chen X, Duan H, Cheng HL, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, ... ... Alt FW, et al. Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. Cell. 166: 1471-1484.e18. PMID 27610571 DOI: 10.1016/j.cell.2016.07.029  1
2016 Kumar V, Alt FW, Frock RL. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601633 DOI: 10.1073/pnas.1611882113  1
2016 Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. The Journal of Experimental Medicine. PMID 27526713 DOI: 10.1084/jem.20160670  0.68
2016 Lin SG, Ba Z, Du Z, Zhang Y, Hu J, Alt FW. Highly sensitive and unbiased approach for elucidating antibody repertoires. Proceedings of the National Academy of Sciences of the United States of America. PMID 27354528 DOI: 10.1073/pnas.1608649113  0.6
2016 Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. Journal of Immunology (Baltimore, Md. : 1950). 196: 3514-6. PMID 27183648  0.6
2016 Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nature Protocols. 11: 853-71. PMID 27031497 DOI: 10.1038/nprot.2016.043  0.68
2016 Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 113: 2258-63. PMID 26873106 DOI: 10.1073/pnas.1525564113  1
2016 Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 164: 644-55. PMID 26871630 DOI: 10.1016/j.cell.2015.12.039  1
2015 Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW. Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes. Cell. 163: 947-59. PMID 26593423 DOI: 10.1016/j.cell.2015.10.016  1
2015 Yeap LS, Hwang JK, Du Z, Meyers RM, Meng FL, Jakubauskaitė A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH, Alt FW. Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell. PMID 26582132 DOI: 10.1016/j.cell.2015.10.042  1
2015 Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 525: 134-9. PMID 26308889 DOI: 10.1038/nature14970  1
2015 Hwang JK, Alt FW, Yeap LS. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiology Spectrum. 3. PMID 26104555 DOI: 10.1128/microbiolspec.MDNA3-0037-2014  1
2015 Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, Alt FW. A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1. Cancer Immunology Research. 3: 641-9. PMID 25934172 DOI: 10.1158/2326-6066.CIR-15-0058  1
2015 Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, et al. An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression. Cell Reports. 11: 715-26. PMID 25921526 DOI: 10.1016/j.celrep.2015.03.059  1
2015 Jiang W, Lee BJ, Li C, Dubois RL, Gostissa M, Alt FW, Zha S. Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency. Blood. 125: 2665-8. PMID 25721125 DOI: 10.1182/blood-2015-01-622621  1
2015 Lin SG, Guo C, Su A, Zhang Y, Alt FW. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 112: 1815-20. PMID 25624508 DOI: 10.1073/pnas.1424936112  1
2015 Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nature Biotechnology. 33: 179-86. PMID 25503383 DOI: 10.1038/nbt.3101  1
2014 Meng FL, Du Z, Federation A, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig MC, Bradner JE, Liu XS, Alt FW. Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability. Cell. 159: 1538-48. PMID 25483776 DOI: 10.1016/j.cell.2014.11.014  0.6
2014 Hu J, Tepsuporn S, Meyers RM, Gostissa M, Alt FW. Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 111: 10269-74. PMID 24982162 DOI: 10.1073/pnas.1410112111  1
2014 Tepsuporn S, Hu J, Gostissa M, Alt FW. Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immunology Research. 2: 857-66. PMID 24913718 DOI: 10.1158/2326-6066.CIR-14-0090  0.6
2014 Kumar V, Alt FW, Oksenych V. Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response". Dna Repair. 17: 52-63. PMID 24767946 DOI: 10.1016/j.dnarep.2014.04.004  1
2014 Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos GD, Murphy AJ. Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes. Proceedings of the National Academy of Sciences of the United States of America. 111: 5147-52. PMID 24706858 DOI: 10.1073/pnas.1323896111  1
2014 Kumar V, Alt FW, Oksenych V. Functional overlaps between XLF and the ATM-dependent DNA double strand break response. Dna Repair. 16: 11-22. PMID 24674624 DOI: 10.1016/j.dnarep.2014.01.010  1
2014 Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proceedings of the National Academy of Sciences of the United States of America. 111: 2644-9. PMID 24550291 DOI: 10.1073/pnas.1324176111  1
2014 Lee YN, Frugoni F, Dobbs K, Walter JE, Giliani S, Gennery AR, Al-Herz W, Haddad E, LeDeist F, Bleesing JH, Henderson LA, Pai SY, Nelson RP, El-Ghoneimy DH, El-Feky RA, ... ... Alt FW, et al. A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. The Journal of Allergy and Clinical Immunology. 133: 1099-108. PMID 24290284 DOI: 10.1016/j.jaci.2013.10.007  1
2014 Meng FL, Alt FW, Tian M. The Mechanism of IgH Class Switch Recombination Molecular Biology of B Cells: Second Edition. 345-362. DOI: 10.1016/B978-0-12-397933-9.00019-9  0.44
2013 Alt F, Reth M. Michael Neuberger (1953-2013). Immunity. 39: 987-8. PMID 24479157  1
2013 Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, ... ... Alt FW, et al. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Reports. 5: 654-65. PMID 24210820 DOI: 10.1016/j.celrep.2013.10.007  1
2013 Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 503: 406-9. PMID 24141948 DOI: 10.1038/nature12637  1
2013 Medvedovic J, Ebert A, Tagoh H, Tamir IM, Schwickert TA, Novatchkova M, Sun Q, Huis In 't Veld PJ, Guo C, Yoon HS, Denizot Y, Holwerda SJ, de Laat W, Cogné M, Shi Y, ... Alt FW, et al. Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity. 39: 229-44. PMID 23973221 DOI: 10.1016/j.immuni.2013.08.011  1
2013 Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW. Microbial colonization influences early B-lineage development in the gut lamina propria. Nature. 501: 112-5. PMID 23965619 DOI: 10.1038/nature12496  1
2013 Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, ... ... Alt FW, et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 153: 1266-80. PMID 23727112 DOI: 10.1016/j.cell.2013.05.023  1
2013 Alt F, Almouzni G. Genome architecture and expression. Current Opinion in Genetics & Development. 23: 79-80. PMID 23642835 DOI: 10.1016/j.gde.2013.04.005  1
2013 Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, ... ... Alt FW, et al. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. Plos Genetics. 9: e1003298. PMID 23408915 DOI: 10.1371/journal.pgen.1003298  1
2013 Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R. Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly. Plos Biology. 11: e1001475. PMID 23382652 DOI: 10.1371/journal.pbio.1001475  1
2013 Gostissa M, Bianco JM, Malkin DJ, Kutok JL, Rodig SJ, Morse HC, Bassing CH, Alt FW. Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proceedings of the National Academy of Sciences of the United States of America. 110: 2934-9. PMID 23382223 DOI: 10.1073/pnas.1222570110  1
2013 Alt FW, Zhang Y, Meng FL, Guo C, Schwer B. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 152: 417-29. PMID 23374339 DOI: 10.1016/j.cell.2013.01.007  1
2013 Rass E, Chandramouly G, Zha S, Alt FW, Xie A. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. The Journal of Biological Chemistry. 288: 7086-95. PMID 23355489 DOI: 10.1074/jbc.M112.445825  1
2013 Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proceedings of the National Academy of Sciences of the United States of America. 110: 2234-9. PMID 23345432 DOI: 10.1073/pnas.1222573110  1
2013 Memarovic N, Cheverst K, Langheinrich M, Elhart I, Alt F. Tethered or free to roam: The design space of limiting content access on community displays Perdis 2013 - Proceedings: 2nd Acm International Symposium On Pervasive Displays 2013. 127-132. DOI: 10.1145/2491568.2491596  0.01
2013 Alt F, Schneegass S, Girgis M, Schmidt A. Cognitive effects of interactive public display applications Perdis 2013 - Proceedings: 2nd Acm International Symposium On Pervasive Displays 2013. 13-18. DOI: 10.1145/2491568.2491572  0.2
2013 Alt F, Marrack P. Anniversary Note - Celebrating 25 years of Publication Current Opinion in Immunology. 25: iv. DOI: 10.1016/S0952-7915(13)00024-1  1
2013 Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy A, Valenzuela D, Luo H, ... ... Alt F, et al. Correction to SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease. [Cell Reports 5, 7, (2013)] 654-665 Cell Reports. 5: 1479. DOI: 10.1016/j.celrep.2013.11.036  1
2012 Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng HL, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, et al. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature. 492: 199-204. PMID 23201684 DOI: 10.1038/nature11700  1
2012 Subrahmanyam R, Du H, Ivanova I, Chakraborty T, Ji Y, Zhang Y, Alt FW, Schatz DG, Sen R. Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions. Nature Immunology. 13: 1205-12. PMID 23104096 DOI: 10.1038/ni.2447  1
2012 Boboila C, Alt FW, Schwer B. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Advances in Immunology. 116: 1-49. PMID 23063072 DOI: 10.1016/B978-0-12-394300-2.00001-6  1
2012 Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infection and Immunity. 80: 4071-7. PMID 22966049 DOI: 10.1128/IAI.06148-11  1
2012 Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW. Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 13745-50. PMID 22869756 DOI: 10.1073/pnas.1210286109  1
2012 Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA, Alt FW, Terhorst C, Notarangelo LD, Snapper SB. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 119: 3966-74. PMID 22411869 DOI: 10.1182/blood-2010-09-308197  1
2012 Zhang Y, McCord RP, Ho YJ, Lajoie BR, Hildebrand DG, Simon AC, Becker MS, Alt FW, Dekker J. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell. 148: 908-21. PMID 22341456 DOI: 10.1016/j.cell.2012.02.002  1
2012 Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proceedings of the National Academy of Sciences of the United States of America. 109: 2473-8. PMID 22308491 DOI: 10.1073/pnas.1121470109  1
2012 Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proceedings of the National Academy of Sciences of the United States of America. 109: 2455-60. PMID 22308489 DOI: 10.1073/pnas.1121458109  1
2012 Yancopoulos GD, Alt FW. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281. Journal of Immunology (Baltimore, Md. : 1950). 188: 10-20. PMID 22187482  1
2012 Memarovic N, Langheinrich M, Alt F, Elhart I, Hosio S, Rubegni E. Using public displays to stimulate passive engagement, active engagement, and discovery in Public spaces Acm International Conference Proceeding Series. 55-64. DOI: 10.1145/2421076.2421086  0.01
2012 Memarovic N, Langheinrich M, Alt F. Interacting places - A framework for promoting community interaction and place awareness through public displays 2012 Ieee International Conference On Pervasive Computing and Communications Workshops, Percom Workshops 2012. 427-430. DOI: 10.1109/PerComW.2012.6197526  0.01
2011 Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. The Journal of Experimental Medicine. 208: 2733-46. PMID 22143888 DOI: 10.1084/jem.20111155  1
2011 Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 147: 107-19. PMID 21962511 DOI: 10.1016/j.cell.2011.07.049  1
2011 Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, ... ... Alt FW, et al. CTCF-binding elements mediate control of V(D)J recombination. Nature. 477: 424-30. PMID 21909113 DOI: 10.1038/nature10495  1
2011 Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, ... Alt FW, et al. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 118: 4169-73. PMID 21878675 DOI: 10.1182/blood-2010-11-318873  1
2011 Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stančáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, ... ... Alt FW, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Molecular Cell. 44: 177-90. PMID 21856199 DOI: 10.1016/j.molcel.2011.07.019  1
2011 Rucci F, Poliani PL, Caraffi S, Paganini T, Fontana E, Giliani S, Alt FW, Notarangelo LD. Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency. Frontiers in Immunology. 2. PMID 21822418 DOI: 10.3389/fimmu.2011.00015  1
2011 Jeevan-Raj BP, Robert I, Heyer V, Page A, Wang JH, Cammas F, Alt FW, Losson R, Reina-San-Martin B. Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. The Journal of Experimental Medicine. 208: 1649-60. PMID 21746811 DOI: 10.1084/jem.20110118  1
2011 Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nature Immunology. 12: 536-43. PMID 21572431 DOI: 10.1038/ni.2037  1
2011 Guo C, Alt FW, Giallourakis C. PAIRing for distal Igh locus V(D)J recombination. Immunity. 34: 139-41. PMID 21349424 DOI: 10.1016/j.immuni.2011.02.010  1
2011 Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proceedings of the National Academy of Sciences of the United States of America. 108: 2873-8. PMID 21282644 DOI: 10.1073/pnas.1019537108  1
2011 Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 144: 353-63. PMID 21255825 DOI: 10.1016/j.cell.2011.01.001  1
2011 Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proceedings of the National Academy of Sciences of the United States of America. 108: 2028-33. PMID 21245310 DOI: 10.1073/pnas.1019293108  1
2011 Eccleston J, Yan C, Yuan K, Alt FW, Selsing E. Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining. Journal of Immunology (Baltimore, Md. : 1950). 186: 2336-43. PMID 21242524 DOI: 10.4049/jimmunol.1003104  1
2011 Gostissa M, Alt FW, Chiarle R. Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annual Review of Immunology. 29: 319-50. PMID 21219174 DOI: 10.1146/annurev-immunol-031210-101329  1
2011 Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 469: 250-4. PMID 21160472 DOI: 10.1038/nature09604  1
2010 Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW. Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 107: 22207-12. PMID 21123744 DOI: 10.1073/pnas.1015954107  1
2010 Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metabolism. 12: 654-61. PMID 21109197 DOI: 10.1016/j.cmet.2010.11.003  1
2010 Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proceedings of the National Academy of Sciences of the United States of America. 107: 21790-4. PMID 21098266 DOI: 10.1073/pnas.1016306107  1
2010 Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW. Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus. Plos One. 5: e13992. PMID 21085586 DOI: 10.1371/journal.pone.0013992  1
2010 Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW. The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Advances in Immunology. 106: 93-133. PMID 20728025 DOI: 10.1016/S0065-2776(10)06004-9  1
2010 Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. The Journal of Experimental Medicine. 207: 1369-80. PMID 20566716 DOI: 10.1084/jem.20100285  1
2010 Walter JE, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, Keszei M, Pessach I, Lang PA, Poliani PL, Giliani S, Al-Herz W, Cowan MJ, Puck JM, Bleesing J, ... ... Alt FW, et al. Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency. The Journal of Experimental Medicine. 207: 1541-54. PMID 20547827 DOI: 10.1084/jem.20091927  1
2010 Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB. Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. The Journal of Experimental Medicine. 207: 1145-52. PMID 20513746 DOI: 10.1084/jem.20091245  1
2010 De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, et al. Hypomorphic Rag mutations can cause destructive midline granulomatous disease. Blood. 116: 1263-71. PMID 20489056 DOI: 10.1182/blood-2010-02-267583  1
2010 Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, ... ... Alt FW, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/nature08778  1
2010 Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. The Journal of Experimental Medicine. 207: 417-27. PMID 20142431 DOI: 10.1084/jem.20092449  1
2010 Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proceedings of the National Academy of Sciences of the United States of America. 107: 3034-9. PMID 20133803 DOI: 10.1073/pnas.0915067107  1
2010 Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proceedings of the National Academy of Sciences of the United States of America. 107: 3040-5. PMID 20133637 DOI: 10.1073/pnas.0915072107  1
2010 Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, ... ... Alt FW, et al. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proceedings of the National Academy of Sciences of the United States of America. 107: 3024-9. PMID 20133615 DOI: 10.1073/pnas.0914865107  1
2010 Sommer CA, Sommer AG, Longmire TA, Christodoulou C, Thomas DD, Gostissa M, Alt FW, Murphy GJ, Kotton DN, Mostoslavsky G. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells (Dayton, Ohio). 28: 64-74. PMID 19904830 DOI: 10.1002/stem.255  1
2009 Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW. Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region. Nature. 462: 803-7. PMID 20010689 DOI: 10.1038/nature08633  1
2009 Lee YN, Alt FW, Reyes J, Gleason M, Zarrin AA, Jung D. Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility. Proceedings of the National Academy of Sciences of the United States of America. 106: 17487-92. PMID 19805067 DOI: 10.1073/pnas.0909723106  1
2009 Zha S, Boboila C, Alt FW. Mre11: roles in DNA repair beyond homologous recombination. Nature Structural & Molecular Biology. 16: 798-800. PMID 19654615 DOI: 10.1038/nsmb0809-798  1
2009 Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 8: 604-6. PMID 19594485 DOI: 10.1111/j.1474-9726.2009.00503.x  1
2009 Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 460: 231-6. PMID 19587764 DOI: 10.1038/nature08159  1
2009 Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Molecular Cell. 34: 285-97. PMID 19450527 DOI: 10.1016/j.molcel.2009.04.025  1
2009 Basu U, Franklin A, Schwer B, Cheng HL, Chaudhuri J, Alt FW. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochemical Society Transactions. 37: 561-8. PMID 19442251 DOI: 10.1042/BST0370561  1
2009 Chakraborty T, Perlot T, Subrahmanyam R, Jani A, Goff PH, Zhang Y, Ivanova I, Alt FW, Sen R. A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. The Journal of Experimental Medicine. 206: 1019-27. PMID 19414554 DOI: 10.1084/jem.20081621  1
2009 Carpenter AC, Yang-Iott KS, Chao LH, Nuskey B, Whitlow S, Alt FW, Bassing CH. Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire. Journal of Immunology (Baltimore, Md. : 1950). 182: 5586-95. PMID 19380806 DOI: 10.4049/jimmunol.0803270  1
2009 Schenten D, Kracker S, Esposito G, Franco S, Klein U, Murphy M, Alt FW, Rajewsky K. Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. The Journal of Experimental Medicine. 206: 477-90. PMID 19204108 DOI: 10.1084/jem.20080669  1
2009 Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J, Phan RT, Datta A, Manis J, Alt FW, Chaudhuri J. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 2717-22. PMID 19196992 DOI: 10.1073/pnas.0812304106  1
2009 Gostissa M, Ranganath S, Bianco JM, Alt FW. Chromosomal location targets different MYC family gene members for oncogenic translocations. Proceedings of the National Academy of Sciences of the United States of America. 106: 2265-70. PMID 19174520 DOI: 10.1073/pnas.0812763106  1
2009 Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nature Medicine. 15: 206-10. PMID 19151729 DOI: 10.1038/nm.1906  1
2009 Giblin W, Chatterji M, Westfield G, Masud T, Theisen B, Cheng HL, DeVido J, Alt FW, Ferguson DO, Schatz DG, Sekiguchi J. Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood. 113: 2965-75. PMID 19126872 DOI: 10.1182/blood-2008-07-165167  1
2009 Basu U, Franklin A, Alt FW. Post-translational regulation of activation-induced cytidine deaminase. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 667-73. PMID 19010772 DOI: 10.1098/rstb.2008.0194  1
2008 Perlot T, Alt FW. Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Advances in Immunology. 99: 1-32. PMID 19117530 DOI: 10.1016/S0065-2776(08)00601-9  1
2008 Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. The Journal of Experimental Medicine. 205: 3079-90. PMID 19064702 DOI: 10.1084/jem.20082271  1
2008 Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, ... ... Alt FW, et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 135: 907-18. PMID 19041753 DOI: 10.1016/j.cell.2008.10.025  1
2008 Basu U, Wang Y, Alt FW. Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Molecular Cell. 32: 285-91. PMID 18951095 DOI: 10.1016/j.molcel.2008.08.019  1
2008 Bassing CH, Whitlow S, Mostoslavsky R, Mostoslovasky R, Yang-Iott K, Ranganath S, Alt FW. Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements. European Journal of Immunology. 38: 2564-72. PMID 18792409 DOI: 10.1002/eji.200838347  1
2008 Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Molecular Cell. 31: 631-40. PMID 18775323 DOI: 10.1016/j.molcel.2008.07.017  1
2008 Takizawa M, Tolarová H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. The Journal of Experimental Medicine. 205: 1949-57. PMID 18678733 DOI: 10.1084/jem.20081007  1
2008 Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 134: 317-28. PMID 18662546 DOI: 10.1016/j.cell.2008.06.050  1
2008 Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proceedings of the National Academy of Sciences of the United States of America. 105: 9302-6. PMID 18599436 DOI: 10.1073/pnas.0803520105  1
2008 Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes & Development. 22: 1662-76. PMID 18559481 DOI: 10.1101/gad.1656808  1
2008 Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes & Development. 22: 1753-7. PMID 18550784 DOI: 10.1101/gad.1650608  1
2008 Zarrin AA, Goff PH, Senger K, Alt FW. Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching. The Journal of Experimental Medicine. 205: 1567-72. PMID 18541713 DOI: 10.1084/jem.20080451  1
2008 Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. The Journal of Experimental Medicine. 205: 557-64. PMID 18316419 DOI: 10.1084/jem.20080044  1
2008 Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proceedings of the National Academy of Sciences of the United States of America. 105: 3374-9. PMID 18296641 DOI: 10.1073/pnas.0712145105  1
2008 Perlot T, Li G, Alt FW. Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proceedings of the National Academy of Sciences of the United States of America. 105: 3843-8. PMID 18292225 DOI: 10.1073/pnas.0712291105  1
2008 Ranganath S, Carpenter AC, Gleason M, Shaw AC, Bassing CH, Alt FW. Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement. Journal of Immunology (Baltimore, Md. : 1950). 180: 2339-46. PMID 18250443  1
2008 Lombard DB, Schwer B, Alt FW, Mostoslavsky R. SIRT6 in DNA repair, metabolism and ageing. Journal of Internal Medicine. 263: 128-41. PMID 18226091 DOI: 10.1111/j.1365-2796.2007.01902.x  1
2008 Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, et al. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Molecular and Cellular Biology. 28: 1688-701. PMID 18180281 DOI: 10.1128/MCB.01154-06  1
2008 Jabara HH, Chaudhuri J, Dutt S, Dedeoglu F, Weng Y, Murphy MM, Franco S, Alt FW, Manis J, Geha RS. B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. The Journal of Allergy and Clinical Immunology. 121: 191-196.e2. PMID 17900678 DOI: 10.1016/j.jaci.2007.08.008  1
2008 Bassing CH, Ranganath S, Murphy M, Savic V, Gleason M, Alt FW. Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Blood. 111: 2163-9. PMID 17855626 DOI: 10.1182/blood-2007-08-104760  1
2008 Takeyama K, Monti S, Manis JP, Dal Cin P, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA. Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas. Oncogene. 27: 318-22. PMID 17637749 DOI: 10.1038/sj.onc.1210650  1
2007 Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Molecular Cell. 28: 1045-57. PMID 18158901 DOI: 10.1016/j.molcel.2007.12.005  1
2007 Wuerffel R, Wang L, Grigera F, Manis J, Selsing E, Perlot T, Alt FW, Cogne M, Pinaud E, Kenter AL. S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity. 27: 711-22. PMID 17980632 DOI: 10.1016/j.immuni.2007.09.007  1
2007 Alt FW. From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology. European Journal of Immunology. 37: S138-47. PMID 17972338 DOI: 10.1002/eji.200737848  1
2007 Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S. SIRT1 controls endothelial angiogenic functions during vascular growth. Genes & Development. 21: 2644-58. PMID 17938244 DOI: 10.1101/gad.435107  1
2007 Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/MCB.01636-07  1
2007 Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proceedings of the National Academy of Sciences of the United States of America. 104: 15424-9. PMID 17878299 DOI: 10.1073/pnas.0706881104  1
2007 Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 449: 478-82. PMID 17713479 DOI: 10.1038/nature06020  1
2007 Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Advances in Immunology. 94: 157-214. PMID 17560275 DOI: 10.1016/S0065-2776(06)94006-1  1
2007 Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nature Immunology. 8: 715-22. PMID 17546032 DOI: 10.1038/ni1476  1
2007 Zha S, Alt FW, Cheng HL, Brush JW, Li G. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4518-23. PMID 17360556 DOI: 10.1073/pnas.0611734104  1
2007 Wu C, Ranganath S, Gleason M, Woodman BB, Borjeson TM, Alt FW, Bassing CH. Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications. Proceedings of the National Academy of Sciences of the United States of America. 104: 4002-7. PMID 17360467 DOI: 10.1073/pnas.0700081104  1
2007 Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. The Embo Journal. 26: 1913-23. PMID 17347648 DOI: 10.1038/sj.emboj.7601633  1
2007 Basu U, Chaudhuri J, Phan RT, Datta A, Alt FW. Regulation of activation induced deaminase via phosphorylation. Advances in Experimental Medicine and Biology. 596: 129-37. PMID 17338181 DOI: 10.1007/0-387-46530-8_11  1
2007 Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW. Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science (New York, N.Y.). 315: 377-81. PMID 17170253 DOI: 10.1126/science.1136386  0.44
2007 Gupta S, Alt F, Cooper M, Melchers F, Rajewsky K. Advances in Experimental Medicine and Biology: Preface Advances in Experimental Medicine and Biology. 596: vii-viii.  1
2006 Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC. Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 103: 16406-11. PMID 17062750 DOI: 10.1073/pnas.0608130103  1
2006 Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/j.cell.2006.06.057  1
2006 Franco S, Alt FW, Manis JP. Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. Dna Repair. 5: 1030-41. PMID 16934538 DOI: 10.1016/j.dnarep.2006.05.024  0.48
2006 Aifantis I, Bassing CH, Garbe AI, Sawai K, Alt FW, von Boehmer H. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. The Journal of Experimental Medicine. 203: 1543-50. PMID 16754716 DOI: 10.1084/jem.20051711  1
2006 Shen RR, Ferguson DO, Renard M, Hoyer KK, Kim U, Hao X, Alt FW, Roeder RG, Morse HC, Teitell MA. Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation. Blood. 108: 1991-8. PMID 16728701 DOI: 10.1182/blood-2006-02-001354  1
2006 Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, ... ... Alt FW, et al. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 7378-83. PMID 16670198 DOI: 10.1073/pnas.0601938103  1
2006 Puebla-Osorio N, Lacey DB, Alt FW, Zhu C. Early embryonic lethality due to targeted inactivation of DNA ligase III. Molecular and Cellular Biology. 26: 3935-41. PMID 16648486 DOI: 10.1128/MCB.26.10.3935-3941.2006  1
2006 Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes & Development. 20: 1256-61. PMID 16648462 DOI: 10.1101/gad.1412706  1
2006 Jung D, Giallourakis C, Mostoslavsky R, Alt FW. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annual Review of Immunology. 24: 541-70. PMID 16551259 DOI: 10.1146/annurev.immunol.23.021704.115830  0.36
2006 Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB. 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 3310-5. PMID 16492765 DOI: 10.1073/pnas.0511259103  1
2006 Longerich S, Basu U, Alt F, Storb U. AID in somatic hypermutation and class switch recombination. Current Opinion in Immunology. 18: 164-74. PMID 16464563 DOI: 10.1016/j.coi.2006.01.008  1
2006 Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, ... ... Alt FW, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 124: 315-29. PMID 16439206 DOI: 10.1016/j.cell.2005.11.044  1
2006 Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, ... Alt FW, et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Molecular Cell. 21: 201-14. PMID 16427010 DOI: 10.1016/j.molcel.2006.01.005  1
2006 Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Molecular Cell. 21: 187-200. PMID 16427009 DOI: 10.1016/j.molcel.2005.11.025  1
2006 O'Neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT. Activating Notch1 mutations in mouse models of T-ALL. Blood. 107: 781-5. PMID 16166587 DOI: 10.1182/blood-2005-06-2553  1
2005 Schelonka RL, Ivanov II, Jung DH, Ippolito GC, Nitschke L, Zhuang Y, Gartland GL, Pelkonen J, Alt FW, Rajewsky K, Schroeder HW. A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. Journal of Immunology (Baltimore, Md. : 1950). 175: 6624-32. PMID 16272317  1
2005 Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, Li G, Schrum JP, Manis JP, Alt FW. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature. 438: 508-11. PMID 16251902 DOI: 10.1038/nature04255  1
2005 Perlot T, Alt FW, Bassing CH, Suh H, Pinaud E. Elucidation of IgH intronic enhancer functions via germ-line deletion. Proceedings of the National Academy of Sciences of the United States of America. 102: 14362-7. PMID 16186486 DOI: 10.1073/pnas.0507090102  1
2005 Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metabolism. 2: 67-76. PMID 16054100 DOI: 10.1016/j.cmet.2005.06.007  1
2005 Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW. DNA repair, genome stability, and aging. Cell. 120: 497-512. PMID 15734682 DOI: 10.1016/j.cell.2005.01.028  1
2005 Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Advances in Immunology. 86: 43-112. PMID 15705419 DOI: 10.1016/S0065-2776(04)86002-4  1
2005 Rooney S, Alt FW, Sekiguchi J, Manis JP. Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proceedings of the National Academy of Sciences of the United States of America. 102: 2471-5. PMID 15699324 DOI: 10.1073/pnas.0409857102  0.6
2005 Zarrin AA, Tian M, Wang J, Borjeson T, Alt FW. Influence of switch region length on immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 102: 2466-70. PMID 15684074 DOI: 10.1073/pnas.0409847102  0.44
2005 Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y. Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Molecular and Cellular Biology. 25: 661-70. PMID 15632067 DOI: 10.1128/MCB.25.2.661-670.2005  0.6
2004 Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R. Control of sister chromatid recombination by histone H2AX. Molecular Cell. 16: 1017-25. PMID 15610743 DOI: 10.1016/j.molcel.2004.12.007  1
2004 Zarrin AA, Alt FW, Chaudhuri J, Stokes N, Kaushal D, Du Pasquier L, Tian M. An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nature Immunology. 5: 1275-81. PMID 15531884 DOI: 10.1038/ni1137  1
2004 Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nature Immunology. 5: 1251-9. PMID 15516924 DOI: 10.1038/ni1135  1
2004 Mostoslavsky R, Alt FW, Rajewsky K. The lingering enigma of the allelic exclusion mechanism. Cell. 118: 539-44. PMID 15339659 DOI: 10.1016/j.cell.2004.08.023  1
2004 Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y. Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice. Nucleic Acids Research. 32: 4539-49. PMID 15328366 DOI: 10.1093/nar/gkh778  1
2004 Bassing CH, Alt FW. The cellular response to general and programmed DNA double strand breaks. Dna Repair. 3: 781-96. PMID 15279764 DOI: 10.1016/j.dnarep.2004.06.001  1
2004 Chaudhuri J, Khuong C, Alt FW. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature. 430: 992-8. PMID 15273694 DOI: 10.1038/nature02821  0.56
2004 Senoo M, Manis JP, Alt FW, McKeon F. p63 and p73 are not required for the development and p53-dependent apoptosis of T cells. Cancer Cell. 6: 85-9. PMID 15261144 DOI: 10.1016/j.ccr.2004.06.005  1
2004 Rooney S, Chaudhuri J, Alt FW. The role of the non-homologous end-joining pathway in lymphocyte development. Immunological Reviews. 200: 115-31. PMID 15242400 DOI: 10.1111/j.0105-2896.2004.00165.x  0.56
2004 Chaudhuri J, Alt FW. Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nature Reviews. Immunology. 4: 541-52. PMID 15229473 DOI: 10.1038/nri1395  0.56
2004 Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes & Development. 18: 1293-304. PMID 15175261 DOI: 10.1101/gad.1209204  1
2004 Mills KD, Ferguson DO, Essers J, Eckersdorff M, Kanaar R, Alt FW. Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes & Development. 18: 1283-92. PMID 15175260 DOI: 10.1101/gad.1204304  1
2004 Giallourakis C, Alt FW, Bassing CH. V(D)J recombinational accessibility-heading in the opposite direction? Nature Immunology. 5: 561-2. PMID 15164012 DOI: 10.1038/ni0604-561  1
2004 Mostoslavsky R, Alt FW. Receptor revision in T cells: an open question? Trends in Immunology. 25: 276-9. PMID 15145316 DOI: 10.1016/j.it.2004.04.001  0.36
2004 Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nature Immunology. 5: 481-7. PMID 15077110 DOI: 10.1038/ni1067  0.48
2004 Bassing CH, Alt FW. Molecular biology: case of mistaken identity. Nature. 428: 29-31. PMID 14999268 DOI: 10.1038/428029a  1
2004 Tian M, Jones DA, Smith M, Shinkura R, Alt FW. Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation. Molecular and Cellular Biology. 24: 2237-42. PMID 14993263  0.44
2004 Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW. Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 2410-5. PMID 14983023  0.6
2004 Dedeoglu F, Horwitz B, Chaudhuri J, Alt FW, Geha RS. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. International Immunology. 16: 395-404. PMID 14978013  0.56
2004 Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, ... Alt FW, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (New York, N.Y.). 303: 2011-5. PMID 14976264 DOI: 10.1126/science.1094637  1
2004 Jung D, Alt FW. Unraveling V(D)J recombination; insights into gene regulation. Cell. 116: 299-311. PMID 14744439  0.36
2004 Tian M, Shinkura R, Shinkura N, Alt FW. Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Molecular and Cellular Biology. 24: 1200-5. PMID 14729965  0.44
2004 Bassing CH, Alt FW. H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle (Georgetown, Tex.). 3: 149-53. PMID 14712078  1
2003 Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH. Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Molecular Cell. 12: 1511-23. PMID 14690604  0.44
2003 Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. The Journal of Experimental Medicine. 198: 1595-608. PMID 14623913 DOI: 10.1084/jem.20030874  1
2003 Dudley DD, Sekiguchi J, Zhu C, Sadofsky MJ, Whitlow S, DeVido J, Monroe RJ, Bassing CH, Alt FW. Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. The Journal of Experimental Medicine. 198: 1439-50. PMID 14581608 DOI: 10.1084/jem.20030627  1
2003 Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 10794-9. PMID 12960381 DOI: 10.1073/pnas.1934713100  1
2003 Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell. 114: 359-70. PMID 12914700 DOI: 10.1016/S0092-8674(03)00566-X  1
2003 Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. The Embo Journal. 22: 3602-12. PMID 12853475 DOI: 10.1093/emboj/cdg350  1
2003 Mills KD, Ferguson DO, Alt FW. The role of DNA breaks in genomic instability and tumorigenesis. Immunological Reviews. 194: 77-95. PMID 12846809 DOI: 10.1034/j.1600-065X.2003.00060.x  1
2003 Manis JP, Alt FW. Novel antibody switching defects in human patients. The Journal of Clinical Investigation. 112: 19-22. PMID 12840053 DOI: 10.1172/JCI19091  0.48
2003 Mostoslavsky R, Alt FW, Bassing CH. Chromatin dynamics and locus accessibility in the immune system. Nature Immunology. 4: 603-6. PMID 12830134 DOI: 10.1038/ni0703-603  1
2003 Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G. Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. The Journal of Experimental Medicine. 197: 1213-9. PMID 12732663 DOI: 10.1084/jem.20021258  0.48
2003 Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 422: 726-30. PMID 12692563 DOI: 10.1038/nature01574  0.56
2003 Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW. The influence of transcriptional orientation on endogenous switch region function. Nature Immunology. 4: 435-41. PMID 12679811 DOI: 10.1038/ni918  0.44
2003 Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J. Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. The Journal of Experimental Medicine. 197: 553-65. PMID 12615897 DOI: 10.1084/jem.20021891  1
2003 Bassing CH, Tillman RE, Woodman BB, Canty D, Monroe RJ, Sleckman BP, Alt FW. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proceedings of the National Academy of Sciences of the United States of America. 100: 2598-603. PMID 12604775 DOI: 10.1073/pnas.0437943100  1
2003 Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW. Essential role for Vav1 in activation, but not development, of gammadelta T cells. International Immunology. 15: 215-21. PMID 12578851 DOI: 10.1093/intimm/dxg021  1
2003 Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421: 643-8. PMID 12540856 DOI: 10.1038/nature01385  0.6
2003 Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ. Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes & Development. 17: 229-39. PMID 12533511 DOI: 10.1101/gad.1045603  0.44
2003 Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA. Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 1209-14. PMID 12531919 DOI: 10.1073/pnas.0237043100  1
2003 Manis JP, Michaelson JS, Birshtein BK, Alt FW. Elucidation of a downstream boundary of the 3' IgH regulatory region. Molecular Immunology. 39: 753-60. PMID 12531286 DOI: 10.1016/S0161-5890(02)00256-0  1
2003 Wu C, Bassing CH, Jung D, Woodman BB, Foy D, Alt FW. Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence. Immunity. 18: 75-85. PMID 12530977 DOI: 10.1016/S1074-7613(02)00515-0  1
2003 Jung D, Bassing CH, Fugmann SD, Cheng HL, Schatz DG, Alt FW. Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. Immunity. 18: 65-74. PMID 12530976 DOI: 10.1016/S1074-7613(02)00507-1  1
2003 Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB. Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice. Blood. 101: 2159-66. PMID 12433691 DOI: 10.1182/blood-2002-05-1423  1
2002 Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, Alt FW. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Molecular Cell. 10: 1379-90. PMID 12504013 DOI: 10.1016/S1097-2765(02)00755-4  1
2002 Yang XF, Ye Q, Press B, Han RZ, Bassing CH, Sleckman BP, Alt FW, Cantor H. Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation. Molecular Immunology. 39: 45-55. PMID 12213327 DOI: 10.1016/S0161-5890(02)00049-4  1
2002 Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity. 17: 41-50. PMID 12150890 DOI: 10.1016/S1074-7613(02)00334-5  1
2002 Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW. Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proceedings of the National Academy of Sciences of the United States of America. 99: 9984-9. PMID 12114543 DOI: 10.1073/pnas.152333499  1
2002 Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, Gao Y, Morton CC, Alt FW. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell. 109: 811-21. PMID 12110179 DOI: 10.1016/S0092-8674(02)00770-5  1
2002 Ye Q, Press B, Kissler S, Yang XF, Lu L, Bassing CH, Sleckman BP, Jansson M, Panoutsakopoulou V, Trimble LA, Alt FW, Cantor H. T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. The Journal of Experimental Medicine. 196: 87-95. PMID 12093873 DOI: 10.1084/jem.20012084  1
2002 Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proceedings of the National Academy of Sciences of the United States of America. 99: 8173-8. PMID 12034884 DOI: 10.1073/pnas.122228699  1
2002 Chua KF, Alt FW, Manis JP. The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. The Journal of Experimental Medicine. 195: F37-41. PMID 11994429  1
2002 Bassing CH, Swat W, Alt FW. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 109: S45-55. PMID 11983152 DOI: 10.1016/S0092-8674(02)00675-X  1
2002 Manis JP, Dudley D, Kaylor L, Alt FW. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity. 16: 607-17. PMID 11970883 DOI: 10.1016/S1074-7613(02)00306-0  1
2002 Inlay M, Alt FW, Baltimore D, Xu Y. Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nature Immunology. 3: 463-8. PMID 11967540 DOI: 10.1038/ni790  1
2002 Krawczyk C, Oliveira-dos-Santos A, Sasaki T, Griffiths E, Ohashi PS, Snapper S, Alt F, Penninger JM. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 16: 331-43. PMID 11911819 DOI: 10.1016/S1074-7613(02)00291-1  1
2002 Manis JP, Tian M, Alt FW. Mechanism and control of class-switch recombination. Trends in Immunology. 23: 31-9. PMID 11801452  0.48
2002 Malynn BA, Shaw AC, Young F, Stewart V, Alt FW. Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells. Molecular Immunology. 38: 547-56. PMID 11750656 DOI: 10.1016/S0161-5890(01)00085-2  1
2001 Sekiguchi JA, Whitlow S, Alt FW. Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs. Molecular Cell. 8: 1383-90. PMID 11779512  0.32
2001 Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Molecular Cell. 8: 1187-96. PMID 11779495 DOI: 10.1016/S1097-2765(01)00425-7  1
2001 Tsitsikov EN, Laouini D, Dunn IF, Sannikova TY, Davidson L, Alt FW, Geha RS. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity. 15: 647-57. PMID 11672546  0.56
2001 Ferguson DO, Alt FW. DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene. 20: 5572-9. PMID 11607810 DOI: 10.1038/sj.onc.1204767  0.44
2001 Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, ... ... Alt FW, et al. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nature Cell Biology. 3: 897-904. PMID 11584271 DOI: 10.1038/ncb1001-897  1
2001 Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 412: 300-7. PMID 11460154 DOI: 10.1038/35085509  0.32
2001 Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proceedings of the National Academy of Sciences of the United States of America. 98: 3243-8. PMID 11248063 DOI: 10.1073/pnas.051632098  1
2001 de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 14: 45-55. PMID 11163229 DOI: 10.1016/S1074-7613(01)00088-7  1
2000 Ferguson DO, Sekiguchi JM, Frank KM, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA, Alt FW. The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 65: 395-403. PMID 12760055  1
2000 Gärtner F, Alt FW, Monroe RJ, Seidl KJ. Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. The Journal of Experimental Medicine. 192: 1745-54. PMID 11120771 DOI: 10.1084/jem.192.12.1745  1
2000 Krawczyk C, Bachmaier K, Sasaki T, Jones RG, Snapper SB, Bouchard D, Kozieradzki I, Ohashi PS, Alt FW, Penninger JM. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 13: 463-73. PMID 11070165  1
2000 Tian M, Alt FW. RNA editing meets DNA shuffling. Nature. 407: 31, 33. PMID 10993058 DOI: 10.1038/35024189  0.44
2000 Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genetics. 26: 85-8. PMID 10973255 DOI: 10.1038/79232  1
2000 O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes & Development. 14: 2185-91. PMID 10970882 DOI: 10.1101/gad.827200  1
2000 Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W. Vav family proteins couple to diverse cell surface receptors. Molecular and Cellular Biology. 20: 6364-73. PMID 10938113 DOI: 10.1128/MCB.20.17.6364-6373.2000  1
2000 Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Molecular Cell. 5: 993-1002. PMID 10911993  1
2000 Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Current Biology : Cb. 10: 758-65. PMID 10898977 DOI: 10.1016/S0960-9822(00)00571-6  1
2000 Sleckman BP, Bassing CH, Hughes MM, Okada A, D'Auteuil M, Wehrly TD, Woodman BB, Davidson L, Chen J, Alt FW. Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments. Proceedings of the National Academy of Sciences of the United States of America. 97: 7975-80. PMID 10869424 DOI: 10.1073/pnas.130190597  1
2000 Bassing CH, Alt FW, Hughes MM, D'Auteuil M, Wehrly TD, Woodman BB, Gärtner F, White JM, Davidson L, Sleckman BP. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 405: 583-6. PMID 10850719 DOI: 10.1038/35014635  1
2000 Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes & Development. 14: 1390-9. PMID 10837031  1
2000 Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn BA, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM, Jenkins NA, Berman JE, Alt FW. Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Molecular and Cellular Biology. 20: 4405-10. PMID 10825203 DOI: 10.1128/MCB.20.12.4405-4410.2000  0.56
2000 Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proceedings of the National Academy of Sciences of the United States of America. 97: 6630-3. PMID 10823907 DOI: 10.1073/pnas.110152897  1
2000 Tian M, Alt FW. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. The Journal of Biological Chemistry. 275: 24163-72. PMID 10811812 DOI: 10.1074/jbc.M003343200  0.44
2000 Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature. 404: 897-900. PMID 10786799 DOI: 10.1038/35009138  0.6
2000 Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 2668-73. PMID 10716994  0.6
2000 Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 3336-41. PMID 10716718 DOI: 10.1073/pnas.050584897  1
1999 Sekiguchi JM, Gao Y, Gu Y, Frank K, Sun Y, Chaudhuri J, Zhu C, Cheng HL, Manis J, Ferguson D, Davidson L, Greenberg ME, Alt FW. Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis. Cold Spring Harbor Symposia On Quantitative Biology. 64: 169-81. PMID 11232282  1
1999 Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC. Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochemical Society Transactions. 27: 624-9. PMID 10917654  1
1999 Monroe RJ, Chen F, Ferrini R, Davidson L, Alt FW. RAG2 is regulated differentially in B and T cells by elements 5' of the promoter. Proceedings of the National Academy of Sciences of the United States of America. 96: 12713-8. PMID 10535988 DOI: 10.1073/pnas.96.22.12713  1
1999 Monroe RJ, Seidl KJ, Gaertner F, Han S, Chen F, Sekiguchi J, Wang J, Ferrini R, Davidson L, Kelsoe G, Alt FW. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity. 11: 201-12. PMID 10485655 DOI: 10.1016/S1074-7613(00)80095-3  1
1999 Gärtner F, Alt FW, Monroe R, Chu M, Sleckman BP, Davidson L, Swat W. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion. Immunity. 10: 537-46. PMID 10367899  0.56
1999 Monroe RJ, Sleckman BP, Monroe BC, Khor B, Claypool S, Ferrini R, Davidson L, Alt FW. Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer. Immunity. 10: 503-13. PMID 10367896 DOI: 10.1016/S1074-7613(00)80050-3  1
1999 Seidl KJ, Manis JP, Bottaro A, Zhang J, Davidson L, Kisselgof A, Oettgen H, Alt FW. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proceedings of the National Academy of Sciences of the United States of America. 96: 3000-5. PMID 10077626  0.56
1999 Shaw AC, Swat W, Davidson L, Alt FW. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. Proceedings of the National Academy of Sciences of the United States of America. 96: 2239-43. PMID 10051625 DOI: 10.1073/pnas.96.5.2239  1
1999 Sakai E, Bottaro A, Davidson L, Sleckman BP, Alt FW. Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proceedings of the National Academy of Sciences of the United States of America. 96: 1526-31. PMID 9990057  0.56
1999 Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (New York, N.Y.). 283: 393-7. PMID 9888855 DOI: 10.1126/science.283.5400.393  1
1999 Shaw AC, Swat W, Ferrini R, Davidson L, Alt FW. Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. The Journal of Experimental Medicine. 189: 123-9. PMID 9874569 DOI: 10.1084/jem.189.1.123  1
1998 Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, ... ... Alt FW, et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 95: 891-902. PMID 9875844 DOI: 10.1016/S0092-8674(00)81714-6  1
1998 Sleckman BP, Bassing CH, Bardon CG, Okada A, Khor B, Bories JC, Monroe R, Alt FW. Accessibility control of variable region gene assembly during T-cell development. Immunological Reviews. 165: 121-30. PMID 9850857  1
1998 Seidl KJ, Bottaro A, Vo A, Zhang J, Davidson L, Alt FW. An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching. International Immunology. 10: 1683-92. PMID 9846697 DOI: 10.1093/intimm/10.11.1683  1
1998 Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL, Davidson L, Kangaloo L, Alt FW. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 396: 173-7. PMID 9823897 DOI: 10.1038/24172  0.56
1998 Sleckman BP, Khor B, Monroe R, Alt FW. Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion. The Journal of Experimental Medicine. 188: 1465-71. PMID 9782123  0.36
1998 Manis JP, van der Stoep N, Tian M, Ferrini R, Davidson L, Bottaro A, Alt FW. Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers. The Journal of Experimental Medicine. 188: 1421-31. PMID 9782119 DOI: 10.1084/jem.188.8.1421  1
1998 Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity. 9: 367-76. PMID 9768756  0.56
1998 Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. The Journal of Experimental Medicine. 188: 833-44. PMID 9730885 DOI: 10.1084/jem.188.5.833  1
1998 Snapper SB, Rosen FS, Mizoguchi E, Cohen P, Khan W, Liu CH, Hagemann TL, Kwan SP, Ferrini R, Davidson L, Bhan AK, Alt FW. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 9: 81-91. PMID 9697838  0.56
1998 Pivniouk V, Tsitsikov E, Swinton P, Rathbun G, Alt FW, Geha RS. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell. 94: 229-38. PMID 9695951  0.4
1998 Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes & Development. 12: 2392-402. PMID 9694803  1
1998 van der Stoep N, Gorman JR, Alt FW. Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation. Immunity. 8: 743-50. PMID 9655488 DOI: 10.1016/S1074-7613(00)80579-8  1
1998 Manis JP, Gu Y, Lansford R, Sonoda E, Ferrini R, Davidson L, Rajewsky K, Alt FW. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. The Journal of Experimental Medicine. 187: 2081-9. PMID 9625768  0.56
1998 Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 8: 625-34. PMID 9620683  0.56
1998 Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Current Biology : Cb. 8: 563-72. PMID 9601640  1
1998 Lansford R, Manis JP, Sonoda E, Rajewsky K, Alt FW. Ig heavy chain class switching in Rag-deficient mice. International Immunology. 10: 325-32. PMID 9576620  0.48
1998 Irving BA, Alt FW, Killeen N. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science (New York, N.Y.). 280: 905-8. PMID 9572735 DOI: 10.1126/science.280.5365.905  1
1998 Hata D, Kawakami Y, Inagaki N, Lantz CS, Kitamura T, Khan WN, Maeda-Yamamoto M, Miura T, Han W, Hartman SE, Yao L, Nagai H, Goldfeld AE, Alt FW, Galli SJ, et al. Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. The Journal of Experimental Medicine. 187: 1235-47. PMID 9547335 DOI: 10.1084/jem.187.8.1235  1
1998 Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 8: 125-34. PMID 9462518 DOI: 10.1016/S1074-7613(00)80465-3  1
1997 Fraefel C, Jacoby DR, Lage C, Hilderbrand H, Chou JY, Alt FW, Breakefield XO, Majzoub JA. Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Molecular Medicine (Cambridge, Mass.). 3: 813-25. PMID 9440115  1
1997 Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Cheng HL, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB, Alt FW. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity. 7: 653-65. PMID 9390689 DOI: 10.1016/S1074-7613(00)80386-6  1
1997 Sleckman BP, Bardon CG, Ferrini R, Davidson L, Alt FW. Function of the TCR alpha enhancer in alphabeta and gammadelta T cells. Immunity. 7: 505-15. PMID 9354471  0.56
1997 Mizuta R, Cheng HL, Gao Y, Alt FW. Molecular genetic characterization of XRCC4 function. International Immunology. 9: 1607-13. PMID 9352367  0.56
1997 Porter FD, Drago J, Xu Y, Cheema SS, Wassif C, Huang SP, Lee E, Grinberg A, Massalas JS, Bodine D, Alt F, Westphal H. Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development (Cambridge, England). 124: 2935-44. PMID 9247336  0.6
1997 Gu Y, Jin S, Gao Y, Weaver DT, Alt FW. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 94: 8076-81. PMID 9223317  0.36
1997 Mizuta R, LaSalle JM, Cheng HL, Shinohara A, Ogawa H, Copeland N, Jenkins NA, Lalande M, Alt FW. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 6927-32. PMID 9192668 DOI: 10.1073/pnas.94.13.6927  1
1997 Merrell K, Wells S, Henderson A, Gorman J, Alt F, Stall A, Calame K. The absence of the transcription activator TFE3 impairs activation of B cells in vivo. Molecular and Cellular Biology. 17: 3335-44. PMID 9154832  1
1997 Kawakami Y, Miura T, Bissonnette R, Hata D, Khan WN, Kitamura T, Maeda-Yamamoto M, Hartman SE, Yao L, Alt FW, Kawakami T. Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 94: 3938-42. PMID 9108083 DOI: 10.1073/pnas.94.8.3938  1
1997 Khan WN, Nilsson A, Mizoguchi E, Castigli E, Forsell J, Bhan AK, Geha R, Sideras P, Alt FW. Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. International Immunology. 9: 395-405. PMID 9088978 DOI: 10.1093/intimm/9.3.395  1
1996 Xu Y, Davidson L, Alt FW, Baltimore D. Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus. Proceedings of the National Academy of Sciences of the United States of America. 93: 2169-73. PMID 8700903  1
1996 Xu Y, Davidson L, Alt FW, Baltimore D. Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement. Immunity. 4: 377-85. PMID 8612132  1
1993 Xu Y, Baldassare M, Fisher P, Rathbun G, Oltz EM, Yancopoulos GD, Jessell TM, Alt FW. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 227-31. PMID 7678338  1
1992 Morrow MA, Lee G, Gillis S, Yancopoulos GD, Alt FW. Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. Genes & Development. 6: 61-70. PMID 1730410  1
1992 Oltz EM, Yancopoulos GD, Morrow MA, Rolink A, Lee G, Wong F, Kaplan K, Gillis S, Melchers F, Alt FW. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. The Embo Journal. 11: 2759-67. PMID 1628631  1
1992 Smith RK, Zimmerman K, Yancopoulos GD, Ma A, Alt FW. Transcriptional down-regulation of N-myc expression during B-cell development. Molecular and Cellular Biology. 12: 1578-84. PMID 1549113  0.64
1992 Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. 1978. Biotechnology (Reading, Mass.). 24: 397-410. PMID 1422048  1
1991 Alt FW, Rathbun G, Yancopoulos GD. DNA recombination in the brain? Current Biology : Cb. 1: 3-5. PMID 15336189  0.64
1991 DePinho RA, Schreiber-Agus N, Alt FW. myc family oncogenes in the development of normal and neoplastic cells. Advances in Cancer Research. 57: 1-46. PMID 1950701  0.6
1990 Yancopoulos GD, Nolan GP, Pollock R, Prockop S, Li SC, Herzenberg LA, Alt FW. A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. Molecular and Cellular Biology. 10: 1697-704. PMID 2320007  0.64
1990 Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. The Journal of Experimental Medicine. 171: 843-59. PMID 2261012  0.64
1989 Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. The Embo Journal. 8: 735-42. PMID 2785917  0.64
1989 Rathbun G, Alt FW, Yancopoulos GD. Immunology: making antigen-receptor genes. Nature. 342: 863-4. PMID 2594082 DOI: 10.1038/342863a0  0.64
1988 Yancopoulos GD, Alt FW. Reconstruction of an immune system. Science (New York, N.Y.). 241: 1581-3. PMID 3262236  0.64
1988 Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW. Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Current Topics in Microbiology and Immunology. 141: 100-9. PMID 3215042  0.64
1988 Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 54: 453-60. PMID 3135938  0.64
1988 Yancopoulos GD, Malynn BA, Alt FW. Developmentally regulated and strain-specific expression of murine VH gene families. The Journal of Experimental Medicine. 168: 417-35. PMID 3135366  0.64
1987 DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes & Development. 1: 1311-26. PMID 3322939  0.64
1987 Alt FW, Blackwell TK, Yancopoulos GD. Development of the primary antibody repertoire. Science (New York, N.Y.). 238: 1079-87. PMID 3317825  0.64
1987 Malynn BA, Berman JE, Yancopoulos GD, Bona CA, Alt FW. Expression of the immunoglobulin heavy-chain variable gene repertoire. Current Topics in Microbiology and Immunology. 135: 75-94. PMID 3107914  1
1987 Alt FW, Yancopoulos GD. Circular T-cell receptor gene recombination products. Nature. 327: 189-90. PMID 3106830 DOI: 10.1038/327189a0  0.64
1987 Legouy E, DePinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, Kriz R, Alt FW. Structure and expression of the murine L-myc gene. The Embo Journal. 6: 3359-66. PMID 2828024  0.44
1986 Depinho RA, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Alt F. Myc family genes: a dispersed multi-gene family. Annals of Clinical Research. 18: 284-9. PMID 3551773  0.6
1986 DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW. Structure and expression of the murine N-myc gene. Proceedings of the National Academy of Sciences of the United States of America. 83: 1827-31. PMID 3513190  1
1986 Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature. 319: 73-7. PMID 3510398 DOI: 10.1038/319073a0  1
1986 Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature. 324: 585-9. PMID 3491327 DOI: 10.1038/324585a0  0.64
1986 Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature. 322: 179-81. PMID 3487737 DOI: 10.1038/322179a0  0.6
1986 Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell. 44: 251-9. PMID 3484682  0.64
1986 Yancopoulos GD, Alt FW. Regulation of the assembly and expression of variable-region genes. Annual Review of Immunology. 4: 339-68. PMID 3085692 DOI: 10.1146/annurev.iy.04.040186.002011  0.64
1986 Alt FW, Reth MG, Blackwell TK, Yancopoulos GD. Regulation of immunoglobulin variable-region gene assembly. The Mount Sinai Journal of Medicine, New York. 53: 166-9. PMID 3084957  0.64
1986 Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocyte differentiation. Immunological Reviews. 89: 5-30. PMID 3081433  0.64
1986 Alt FW, DePinho R, Zimmerman K, Legouy E, Hatton K, Ferrier P, Tesfaye A, Yancopoulos G, Nisen P. The human myc gene family. Cold Spring Harbor Symposia On Quantitative Biology. 51: 931-41. PMID 3034500  0.44
1986 Yancopoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. The Embo Journal. 5: 3259-66. PMID 3028778  1
1985 Yancopoulos GD, Nisen PD, Tesfaye A, Kohl NE, Goldfarb MP, Alt FW. N-myc can cooperate with ras to transform normal cells in culture. Proceedings of the National Academy of Sciences of the United States of America. 82: 5455-9. PMID 3860871 DOI: 10.1073/pnas.82.16.5455  1
1985 Yancopoulos GD, Alt FW. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 40: 271-81. PMID 2578321  0.64
1984 DePinho R, Kruger K, Andrews N, Lutzker S, Baltimore D, Alt FW. Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line. Molecular and Cellular Biology. 4: 2905-10. PMID 6098827  1
1984 Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW, Baltimore D. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature. 311: 752-5. PMID 6092963 DOI: 10.1038/311752a0  1
1984 Yancopoulos GD, Desiderio SV, Paskind M, Kearney JF, Baltimore D, Alt FW. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature. 311: 727-33. PMID 6092962 DOI: 10.1038/311727a0  0.64
1984 Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. The Embo Journal. 3: 1209-19. PMID 6086308  1
1983 Kanda N, Schreck R, Alt F, Bruns G, Baltimore D, Latt S. Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 80: 4069-73. PMID 6575396  1
1982 Alt FW, Rosenberg N, Enea V, Siden E, Baltimore D. Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Molecular and Cellular Biology. 2: 386-400. PMID 6810096  1
1982 Alt FW, Rosenberg N, Casanova RJ, Thomas E, Baltimore D. Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line. Nature. 296: 325-31. PMID 6801527  1
1982 Lewis S, Rosenberg N, Alt F, Baltimore D. Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cell. 30: 807-16. PMID 6291785  1
1982 Alt FW, Baltimore D. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proceedings of the National Academy of Sciences of the United States of America. 79: 4118-22. PMID 6287467  1
1981 Mather EL, Alt FW, Bothwell AL, Baltimore D, Koshland ME. Expression of J chain RNA in cell lines representing different stages of B lymphocyte differentiation. Cell. 23: 369-78. PMID 6781757  1
1981 Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D. Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell. 27: 381-90. PMID 6277505  1
1981 Siden E, Alt FW, Shinefeld L, Sato V, Baltimore D. Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America. 78: 1823-7. PMID 6112749  1
1980 Alt FW, Enea V, Bothwell AL, Baltimore D. Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell. 21: 1-12. PMID 6773666  1
1980 Alt FW, Bothwell AL, Knapp M, Siden E, Mather E, Koshland M, Baltimore D. Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell. 20: 293-301. PMID 6771018  1
1979 Kellems RE, Morhenn VB, Pfendt EA, Alt FW, Schimke RT. Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts. The Journal of Biological Chemistry. 254: 309-18. PMID 216671  1
1978 Schimke RT, Kaufman RJ, Alt FW, Kellems RF. Gene amplification and drug resistance in cultured murine cells. Science (New York, N.Y.). 202: 1051-5. PMID 715457  1
1978 Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. The Journal of Biological Chemistry. 253: 1357-70. PMID 627542  1
1978 Schimke RT, Alt FW, Kellems RE, Kaufman RJ, Bertino JR. Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harbor Symposia On Quantitative Biology. 42: 649-57. PMID 277312  1
1976 Alt FW, Kellems RE, Schimke RT. Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. The Journal of Biological Chemistry. 251: 3063-74. PMID 944697  1
1976 Kellems RE, Alt FW, Schimke RT. Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA. The Journal of Biological Chemistry. 251: 6987-93. PMID 62753  1
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