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Anthony Orth - Publications

Affiliations: 
1999-2002 Genomics Genomics Institute of the Novartis Research Foundation 
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23/61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2010 Hu XV, Rodrigues TM, Tao H, Baker RK, Miraglia L, Orth AP, Lyons GE, Schultz PG, Wu X. Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen. Proceedings of the National Academy of Sciences of the United States of America. 107: 15087-92. PMID 20696907 DOI: 10.1073/Pnas.1009025107  0.41
2010 Willis DK, Wang J, Lindholm JR, Orth A, Goodman WG. Microarray analysis of juvenile hormone response in Drosophila melanogaster S2 cells. Journal of Insect Science (Online). 10: 66. PMID 20672983 DOI: 10.1673/031.010.6601  0.376
2010 Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, et al. Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nature Cell Biology. 12: 758-67. PMID 20622870 DOI: 10.1038/Ncb2080  0.444
2010 Gonzalez R, Jennings LL, Knuth M, Orth AP, Klock HE, Ou W, Feuerhelm J, Hull MV, Koesema E, Wang Y, Zhang J, Wu C, Cho CY, Su AI, Batalov S, et al. Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency. Proceedings of the National Academy of Sciences of the United States of America. 107: 3552-7. PMID 20133595 DOI: 10.1073/Pnas.0914019107  0.646
2010 Wurdak H, Zhu S, Romero A, Lorger M, Watson J, Chiang CY, Zhang J, Natu VS, Lairson LL, Walker JR, Trussell CM, Harsh GR, Vogel H, Felding-Habermann B, Orth AP, et al. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation. Cell Stem Cell. 6: 37-47. PMID 20085741 DOI: 10.1016/J.Stem.2009.11.002  0.45
2009 Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tu BP, Miraglia L, Walker J, Sun F, Orth A, Schultz PG, Wu X. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proceedings of the National Academy of Sciences of the United States of America. 106: 17025-30. PMID 19805117 DOI: 10.1073/Pnas.0909292106  0.563
2009 Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg MH, Cho CY, Schultz PG. A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorganic & Medicinal Chemistry. 17: 977-80. PMID 18329275 DOI: 10.1016/J.Bmc.2008.02.067  0.386
2008 Wu C, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL, Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K, et al. Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. Plos Genetics. 4: e1000070. PMID 18464898 DOI: 10.1371/Journal.Pgen.1000070  0.613
2007 Amelio AL, Miraglia LJ, Conkright JJ, Mercer BA, Batalov S, Cavett V, Orth AP, Busby J, Hogenesch JB, Conkright MD. A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 20314-9. PMID 18077367 DOI: 10.1073/Pnas.0707999105  0.582
2007 König R, Chiang CY, Tu BP, Yan SF, DeJesus PD, Romero A, Bergauer T, Orth A, Krueger U, Zhou Y, Chanda SK. A probability-based approach for the analysis of large-scale RNAi screens. Nature Methods. 4: 847-9. PMID 17828270 DOI: 10.1038/Nmeth1089  0.325
2006 Rines DR, Tu B, Miraglia L, Welch GL, Zhang J, Hull MV, Orth AP, Chanda SK. High-content screening of functional genomic libraries. Methods in Enzymology. 414: 530-65. PMID 17110210 DOI: 10.1016/S0076-6879(06)14028-8  0.334
2006 Mukherji M, Bell R, Supekova L, Wang Y, Orth AP, Batalov S, Miraglia L, Huesken D, Lange J, Martin C, Sahasrabudhe S, Reinhardt M, Natt F, Hall J, Mickanin C, et al. Genome-wide functional analysis of human cell-cycle regulators. Proceedings of the National Academy of Sciences of the United States of America. 103: 14819-24. PMID 17001007 DOI: 10.1073/Pnas.0604320103  0.571
2006 Cho CY, Koo SH, Wang Y, Callaway S, Hedrick S, Mak PA, Orth AP, Peters EC, Saez E, Montminy M, Schultz PG, Chanda SK. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metabolism. 3: 367-78. PMID 16679294 DOI: 10.1016/J.Cmet.2006.03.006  0.351
2006 Luesch H, Chanda SK, Raya RM, DeJesus PD, Orth AP, Walker JR, Izpisúa Belmonte JC, Schultz PG. A functional genomics approach to the mode of action of apratoxin A. Nature Chemical Biology. 2: 158-67. PMID 16474387 DOI: 10.1038/Nchembio769  0.551
2005 Willingham AT, Orth AP, Batalov S, Peters EC, Wen BG, Aza-Blanc P, Hogenesch JB, Schultz PG. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Science (New York, N.Y.). 309: 1570-3. PMID 16141075 DOI: 10.1126/Science.1115901  0.626
2005 Harada JN, Bower KE, Orth AP, Callaway S, Nelson CG, Laris C, Hogenesch JB, Vogt PK, Chanda SK. Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis. Genome Research. 15: 1136-44. PMID 16024821 DOI: 10.1101/Gr.3889305  0.616
2005 Liu J, Bang AG, Kintner C, Orth AP, Chanda SK, Ding S, Schultz PG. Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Proceedings of the National Academy of Sciences of the United States of America. 102: 1927-32. PMID 15677333 DOI: 10.1073/Pnas.0409472102  0.513
2004 Orth AP, Batalov S, Perrone M, Chanda SK. The promise of genomics to identify novel therapeutic targets. Expert Opinion On Therapeutic Targets. 8: 587-96. PMID 15584864 DOI: 10.1517/14728222.8.6.587  0.37
2004 Zheng L, Liu J, Batalov S, Zhou D, Orth A, Ding S, Schultz PG. An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 135-40. PMID 14688408 DOI: 10.1073/Pnas.2136685100  0.598
2003 Chanda SK, White S, Orth AP, Reisdorph R, Miraglia L, Thomas RS, DeJesus P, Mason DE, Huang Q, Vega R, Yu DH, Nelson CG, Smith BM, Terry R, Linford AS, et al. Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 100: 12153-8. PMID 14514886 DOI: 10.1073/Pnas.1934839100  0.635
2003 Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 12147-52. PMID 14506290 DOI: 10.1073/Pnas.1932773100  0.395
2003 Orth AP, Doll SC, Goodman WG. Sequence, structure and expression of the hemolymph juvenile hormone binding protein gene in the tobacco hornworm, Manduca sexta. Insect Biochemistry and Molecular Biology. 33: 93-102. PMID 12459204 DOI: 10.1016/S0965-1748(02)00180-7  0.354
2002 Su AI, Cooke MP, Ching KA, Hakak Y, Walker JR, Wiltshire T, Orth AP, Vega RG, Sapinoso LM, Moqrich A, Patapoutian A, Hampton GM, Schultz PG, Hogenesch JB. Large-scale analysis of the human and mouse transcriptomes. Proceedings of the National Academy of Sciences of the United States of America. 99: 4465-70. PMID 11904358 DOI: 10.1073/Pnas.012025199  0.654
Low-probability matches (unlikely to be authored by this person)
2003 Orth AP, Tauchman SJ, Doll SC, Goodman WG. Embryonic expression of juvenile hormone binding protein and its relationship to the toxic effects of juvenile hormone in Manduca sexta. Insect Biochemistry and Molecular Biology. 33: 1275-84. PMID 14599499 DOI: 10.1016/J.Ibmb.2003.06.002  0.288
2014 Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, Reinhardt J, Orth AP, Patapoutian A. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell. 157: 447-58. PMID 24725410 DOI: 10.1016/J.Cell.2014.03.024  0.267
2007 Hancock MK, Medina MN, Smith BM, Orth AP. Microplate orbital mixing improves high-throughput cell-based reporter assay readouts. Journal of Biomolecular Screening. 12: 140-4. PMID 17130249 DOI: 10.1177/1087057106296046  0.267
2011 Murphy SH, Suzuki K, Downes M, Welch GL, De Jesus P, Miraglia LJ, Orth AP, Chanda SK, Evans RM, Verma IM. Tumor suppressor protein (p)53, is a regulator of NF-kappaB repression by the glucocorticoid receptor. Proceedings of the National Academy of Sciences of the United States of America. 108: 17117-22. PMID 21949408 DOI: 10.1073/Pnas.1114420108  0.266
2009 Huang SM, Hancock MK, Pitman JL, Orth AP, Gekakis N. Negative regulators of insulin signaling revealed in a genome-wide functional screen. Plos One. 4: e6871. PMID 19727444 DOI: 10.1371/journal.pone.0006871  0.257
2017 Horman SR, To J, Lamb J, Zoll JH, Leonetti N, Tu B, Moran R, Newlin R, Walker JR, Orth AP. Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets. Oncotarget. 8: 99913-99930. PMID 29245949 DOI: 10.18632/oncotarget.21915  0.254
2012 Chiang CY, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, et al. Cofactors required for TLR7- and TLR9-dependent innate immune responses. Cell Host & Microbe. 11: 306-18. PMID 22423970 DOI: 10.1016/J.Chom.2012.02.002  0.249
2008 Li W, Bengtson MH, Ulbrich A, Matsuda A, Reddy VA, Orth A, Chanda SK, Batalov S, Joazeiro CA. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. Plos One. 3: e1487. PMID 18213395 DOI: 10.1371/Journal.Pone.0001487  0.249
1999 Orth AP, Lan Q, Goodman WG. Ligand regulation of juvenile hormone binding protein mRNA in mutant Manduca sexta. Molecular and Cellular Endocrinology. 149: 61-9. PMID 10375018 DOI: 10.1016/S0303-7207(98)00258-5  0.233
2009 Wang J, Lindholm JR, Willis DK, Orth A, Goodman WG. Juvenile hormone regulation of Drosophila Epac--a guanine nucleotide exchange factor. Molecular and Cellular Endocrinology. 305: 30-7. PMID 19433259 DOI: 10.1016/J.Mce.2009.02.002  0.226
2021 Grandhi TSP, To J, Romero A, Luna F, Barnes W, Walker J, Moran R, Newlin R, Miraglia L, Orth AP, Horman SR. High-throughput CRISPR-mediated 3D enrichment platform for functional interrogation of chemotherapeutic resistance. Biotechnology and Bioengineering. PMID 34050941 DOI: 10.1002/bit.27844  0.22
2014 Bill A, Rosethorne EM, Kent TC, Fawcett L, Burchell L, van Diepen MT, Marelli A, Batalov S, Miraglia L, Orth AP, Renaud NA, Charlton SJ, Gosling M, Gaither LA, Groot-Kormelink PJ. High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function. Plos One. 9: e97973. PMID 24886841 DOI: 10.1371/journal.pone.0097973  0.212
2017 Britschgi A, Duss S, Kim S, Couto JP, Brinkhaus H, Koren S, De Silva D, Mertz KD, Kaup D, Varga Z, Voshol H, Vissieres A, Leroy C, Roloff T, Stadler MB, ... ... Orth AP, et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature. PMID 28068668 DOI: 10.1038/Nature20829  0.204
2013 Horman SR, Janas MM, Litterst C, Wang B, MacRae IJ, Sever MJ, Morrissey DV, Graves P, Luo B, Umesalma S, Qi HH, Miraglia LJ, Novina CD, Orth AP. Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets. Molecular Cell. 50: 356-67. PMID 23603119 DOI: 10.1016/J.Molcel.2013.03.015  0.202
2010 König R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, Bhattacharyya S, Alamares JG, Tscherne DM, Ortigoza MB, Liang Y, Gao Q, Andrews SE, Bandyopadhyay S, De Jesus P, Tu BP, ... ... Orth A, et al. Human host factors required for influenza virus replication. Nature. 463: 813-7. PMID 20027183 DOI: 10.1038/Nature08699  0.199
2013 Horman SR, To J, Orth AP, Slawny N, Cuddihy MJ, Caracino D. High-content analysis of three-dimensional tumor spheroids: investigating signaling pathways using small hairpin RNA Nature Methods. 10: v-vi. DOI: 10.1038/nmeth.f.370  0.191
2018 Xu J, Mathur J, Vessieres E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang F, Mainquist J, Cahalan S, Orth A, et al. Abstract 374: Gpr68 Senses Blood Flow and is Essential for Vascular Physiology Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.374  0.19
2008 König R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, Irelan JT, Chiang CY, Tu BP, De Jesus PD, Lilley CE, Seidel S, Opaluch AM, Caldwell JS, Weitzman MD, Kuhen KL, ... ... Orth AP, et al. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell. 135: 49-60. PMID 18854154 DOI: 10.1016/J.Cell.2008.07.032  0.188
2008 Adams DG, Wang Y, Mak PA, Chyba J, Shalizi O, Matzen J, Anderson P, Smith TR, Garcia M, Welch GL, Claret EJ, Fink M, Orth AP, Caldwell JS, Brinker A. Cellular Ser/Thr-kinase assays using generic peptide substrates. Current Chemical Genomics. 1: 54-64. PMID 20161828 DOI: 10.2174/1875397300801010054  0.187
2021 Bill A, Espinola S, Guthy D, Haling JR, Lanter M, Lu M, Marelli A, Mendiola A, Miraglia L, Taylor BL, Vargas L, Orth AP, King FJ. EndoBind detects endogenous protein-protein interactions in real time. Communications Biology. 4: 1085. PMID 34526658 DOI: 10.1038/s42003-021-02600-5  0.184
2013 Horman SR, To J, Orth AP. An HTS-compatible 3D colony formation assay to identify tumor-specific chemotherapeutics. Journal of Biomolecular Screening. 18: 1298-308. PMID 23918920 DOI: 10.1177/1087057113499405  0.181
2023 Frick EA, Emilsson V, Jonmundsson T, Steindorsdottir AE, Johnson ECB, Puerta R, Dammer EB, Shantaraman A, Cano A, Boada M, Valero S, García-González P, Gudmundsson EF, Gudjonsson A, Loureiro JJ, ... Orth AP, et al. Serum proteomics reveals dependent and independent protein signatures in Alzheimer's disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37986771 DOI: 10.1101/2023.11.08.23298251  0.177
2024 Gudmundsdottir V, Frick E, Emilsson V, Jonmundsson T, Steindorsdottir A, Johnson ECB, Puerta R, Dammer E, Shantaraman A, Cano A, Boada M, Valero S, Garcia-Gonzalez P, Gudmundsson E, Gudjonsson A, ... ... Orth A, et al. Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer's disease. Research Square. PMID 38260284 DOI: 10.21203/rs.3.rs-3706206/v1  0.176
2018 Emilsson V, Ilkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Gudmundsdottir V, Horman SR, Aspelund T, Shu L, Trifonov V, Sigurdsson S, Manolescu A, Zhu J, ... ... Orth AP, et al. Co-regulatory networks of human serum proteins link genetics to disease. Science (New York, N.Y.). PMID 30072576 DOI: 10.1126/Science.Aaq1327  0.174
2018 Xu J, Mathur J, Vessières E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang FL, Mainquist JK, Cahalan SM, Orth AP, et al. GPR68 Senses Flow and Is Essential for Vascular Physiology. Cell. 173: 762-775.e16. PMID 29677517 DOI: 10.1016/J.Cell.2018.03.076  0.167
2018 Veit G, Xu H, Dreano E, Avramescu RG, Bagdany M, Beitel LK, Roldan A, Hancock MA, Lay C, Li W, Morin K, Gao S, Mak PA, Ainscow E, Orth AP, et al. Structure-guided combination therapy to potently improve the function of mutant CFTRs. Nature Medicine. PMID 30297908 DOI: 10.1038/s41591-018-0200-x  0.161
2013 Kim S, Dubrovska A, Salamone RJ, Walker JR, Grandinetti KB, Bonamy GM, Orth AP, Elliott J, Porta DG, Garcia-Echeverria C, Reddy VA. FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. Plos One. 8: e51671. PMID 23300950 DOI: 10.1371/Journal.Pone.0051671  0.161
2006 Bandell M, Dubin AE, Petrus MJ, Orth A, Mathur J, Hwang SW, Patapoutian A. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nature Neuroscience. 9: 493-500. PMID 16520735 DOI: 10.1038/nn1665  0.157
2014 Zhou Z, Patel M, Ng N, Hsieh MH, Orth AP, Walker JR, Batalov S, Harris JL, Liu J. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. Bmc Cancer. 14: 944. PMID 25495526 DOI: 10.1186/1471-2407-14-944  0.15
2016 Groot-Kormelink PJ, Ferrand S, Kelley N, Bill A, Freuler F, Imbert PE, Marelli A, Gerwin N, Sivilotti LG, Miraglia L, Orth AP, Oakeley EJ, Schopfer U, Siehler S. High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. Plos One. 11: e0163129. PMID 27649498 DOI: 10.1371/journal.pone.0163129  0.148
1995 Orth AP, Goodman WG. Juvenile hormone regulation of hemolymph juvenile hormone binding protein in the black strain of the tobacco hornworm,Manduca sexta Archives of Insect Biochemistry and Physiology. 30: 165-176. DOI: 10.1002/Arch.940300207  0.147
2003 Young JK, Orth AP, Goodman WG. Allelic variation in the hemolymph juvenile hormone binding protein gene of Manduca sexta. Molecular and Cellular Endocrinology. 208: 41-50. PMID 14580720 DOI: 10.1016/S0303-7207(03)00259-4  0.141
2024 Axelsson GT, Jonmundsson T, Woo Y, Frick EA, Aspelund T, Loureiro JJ, Orth AP, Jennings LL, Gudmundsson G, Emilsson V, Gudmundsdottir V, Gudnason V. Proteomic associations with forced expiratory volume: a Mendelian randomisation study. Respiratory Research. 25: 44. PMID 38238732 DOI: 10.1186/s12931-023-02587-z  0.12
2007 Tauchman SJ, Lorch JM, Orth AP, Goodman WG. Effects of stress on the hemolymph juvenile hormone binding protein titers of Manduca sexta. Insect Biochemistry and Molecular Biology. 37: 847-54. PMID 17628283 DOI: 10.1016/J.Ibmb.2007.05.015  0.111
1995 Goodman WG, Orth AP, Toong YC, Ebersohl R, Hiruma K, Granger NA. Recent advances in radioimmunoassay technology for the juvenile hormones. Archives of Insect Biochemistry and Physiology. 30: 295-306. PMID 7579576 DOI: 10.1002/Arch.940300215  0.08
2023 Jonmundsson T, Steindorsdottir AE, Austin TR, Frick EA, Axelsson GT, Launer L, Psaty BM, Loureiro J, Orth AP, Aspelund T, Emilsson V, Floyd JS, Jennings L, Gudnason V, Gudmundsdottir V. A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study). Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. PMID 37967346 DOI: 10.1093/europace/euad320  0.048
2013 Horman SR, To J, Orth AP, Slawny N, Cuddihy M, Caracino D. 3D high-content analysis of spheroids Genetic Engineering and Biotechnology News. 33: 18-19. DOI: 10.1089/gen.33.16.08  0.046
2023 Emilsson V, Jonsson BG, Austin TR, Gudmundsdottir V, Axelsson GT, Frick EA, Jonmundsson T, Steindorsdottir AE, Loureiro J, Brody JA, Aspelund T, Launer LJ, Thorgeirsson G, Kortekaas KA, Lindeman JH, ... Orth AP, et al. Proteomic prediction of incident heart failure and its main subtypes. European Journal of Heart Failure. PMID 37936531 DOI: 10.1002/ejhf.3086  0.031
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