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Hening Lin - Publications

Affiliations: 
Chemistry and Chemical Biology Cornell University, Ithaca, NY, United States 
Area:
chemistry, biology, and application of enzymes
Website:
http://chemistry.cornell.edu/faculty/detail.cfm?netid=hl379

123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Latifkar A, Wang F, Mullmann JJ, Panizza E, Fernandez IR, Ling L, Miller AD, Fischbach C, Weiss RS, Lin H, Cerione RA, Antonyak MA. IGF2BP2 promotes cancer progression by degrading the RNA transcript encoding a v-ATPase subunit. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200477119. PMID 36322753 DOI: 10.1073/pnas.2200477119  0.777
2022 Anmangandla A, Ren Y, Fu Q, Zhang S, Lin H. The Acyl-CoA Specificity of Human Lysine Acetyltransferase KAT2A. Biochemistry. PMID 35995428 DOI: 10.1021/acs.biochem.2c00308  0.3
2022 Miller SP, Maio G, Zhang X, Badillo Soto FS, Zhu J, Ramirez SZ, Lin H. A proteomic approach identifies isoform-specific and nucleotide-dependent RAS interactions. Molecular & Cellular Proteomics : McP. 100268. PMID 35839996 DOI: 10.1016/j.mcpro.2022.100268  0.352
2022 Wang F, Latifkar A, Mullmann J, Panizza E, Fernandez I, Ling L, Miller A, Fischbach C, Weiss R, Lin H, Cerione R, Antonyak M. IGF2BP2 Promotes Cancer Progression by Degrading the RNA Transcript Encoding a v-ATPase Subunit. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 35552659 DOI: 10.1096/fasebj.2022.36.S1.L7433  0.514
2022 Wang ZA, Whedon SD, Wu M, Wang S, Brown EA, Anmangandla A, Regan L, Lee K, Du J, Hong JY, Fairall L, Kay T, Lin H, Zhao Y, Schwabe JWR, et al. Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase. Journal of the American Chemical Society. PMID 35175758 DOI: 10.1021/jacs.1c13555  0.411
2021 Hong JY, Malgapo MIP, Liu Y, Yang M, Zhu C, Zhang X, Tolbert P, Linder ME, Lin H. Correction to "High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases". Acs Chemical Biology. PMID 34514789 DOI: 10.1021/acschembio.1c00674  0.362
2021 Hong JY, Malgapo MIP, Liu Y, Yang M, Zhu C, Zhang X, Tolbert P, Linder ME, Lin H. High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases. Acs Chemical Biology. PMID 34374518 DOI: 10.1021/acschembio.1c00258  0.403
2021 Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, ... ... Lin H, et al. Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene. PMID 33479498 DOI: 10.1038/s41388-020-01637-w  0.653
2020 Zhang L, Cao J, Dong L, Lin H. TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 32482854 DOI: 10.1073/Pnas.1921815117  0.308
2020 Kosciuk T, Lin H. NMT as a glycine and lysine myristoyltransferase in cancer, immunity, and infections. Acs Chemical Biology. PMID 32453941 DOI: 10.1021/Acschembio.0C00314  0.377
2020 Kosciuk T, Price IR, Zhang X, Zhu C, Johnson KN, Zhang S, Halaby SL, Komaniecki GP, Yang M, DeHart CJ, Thomas PM, Kelleher NL, Christopher Fromme J, Lin H. NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nature Communications. 11: 1067. PMID 32103017 DOI: 10.1038/S41467-020-14893-X  0.702
2020 Fenwick MK, Su D, Dong M, Lin H, Ealick SE. Structural basis of substrate selectivity of viperin. Biochemistry. PMID 31917549 DOI: 10.1021/Acs.Biochem.9B00741  0.331
2019 Greene KS, Lukey MJ, Wang X, Blank B, Druso JE, Lin MJ, Stalnecker CA, Zhang C, Negrón Abril Y, Erickson JW, Wilson KF, Lin H, Weiss RS, Cerione RA. SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31843902 DOI: 10.1073/Pnas.1911954116  0.539
2019 Fenwick MK, Dong M, Lin H, Ealick SE. Crystal structure of Dph2 in complex with elongation factor 2 reveals structural basis for first step of diphthamide biosynthesis. Biochemistry. PMID 31566354 DOI: 10.1021/Acs.Biochem.9B00718  0.329
2019 Dong M, Dando EE, Kotliar I, Su X, Dzikovski B, Freed JH, Lin H. The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 31463593 DOI: 10.1007/S00775-019-01702-0  0.516
2019 Spiegelman NA, Zhang X, Jing H, Cao J, Kotliar IB, Aramsangtienchai P, Wang M, Tong Z, Rosch KM, Lin H. SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration. Acs Chemical Biology. PMID 31433161 DOI: 10.1021/Acschembio.9B00492  0.473
2019 Hong JY, Price IR, Bai JJ, Lin H. A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors. Acs Chemical Biology. PMID 31373792 DOI: 10.1021/Acschembio.9B00384  0.323
2019 Son SI, Cao J, Zhu CL, Miller SP, Lin H. Activity-Guided Design of HDAC11-Specific Inhibitors. Acs Chemical Biology. PMID 31264832 DOI: 10.1021/Acschembio.9B00292  0.585
2019 Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, ... ... Lin H, et al. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell. 35: 916-931.e9. PMID 31185214 DOI: 10.1016/J.Ccell.2019.05.002  0.513
2019 Zhang S, Spiegelman NA, Lin H. Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling. Methods in Molecular Biology (Clifton, N.J.). 2009: 137-147. PMID 31152401 DOI: 10.1007/978-1-4939-9532-5_11  0.373
2019 Young Hong J, Cao J, Lin H. Fluorogenic Assays for the Defatty-Acylase Activity of Sirtuins. Methods in Molecular Biology (Clifton, N.J.). 2009: 129-136. PMID 31152400 DOI: 10.1007/978-1-4939-9532-5_10  0.359
2019 Farooqi AS, Hong JY, Cao J, Lu X, Price IR, Zhao Q, Kosciuk T, Yang M, Bai JJ, Lin H. Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. Journal of Medicinal Chemistry. PMID 30986062 DOI: 10.1021/Acs.Jmedchem.9B00191  0.309
2019 Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Developmental Cell. PMID 30982660 DOI: 10.1016/J.Devcel.2019.03.011  0.763
2019 Kosciuk T, Wang M, Hong JY, Lin H. Updates on the epigenetic roles of sirtuins. Current Opinion in Chemical Biology. 51: 18-29. PMID 30875552 DOI: 10.1016/J.Cbpa.2019.01.023  0.374
2019 Cao J, Sun L, Aramsangtienchai P, Spiegelman NA, Zhang X, Huang W, Seto E, Lin H. HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2. Proceedings of the National Academy of Sciences of the United States of America. PMID 30819897 DOI: 10.1073/Pnas.1815365116  0.48
2019 Spiegelman NA, Hong JY, Hu J, Jing H, Wang M, Price IR, Cao J, Yang M, Zhang X, Lin H. A Small Molecule SIRT2 Inhibitor that Promotes K-Ras4a Lysine Fatty-acylation. Chemmedchem. PMID 30734528 DOI: 10.1002/Cmdc.201800715  0.463
2019 Wang WW, Angulo-Ibanez M, Lyu J, Kurra Y, Tong Z, Wu B, Zhang L, Sharma V, Zhou J, Lin H, Gao YQ, Li W, Chua KF, Liu WR. A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7. Journal of the American Chemical Society. PMID 30653310 DOI: 10.1021/Jacs.8B12083  0.371
2018 Zhang Y, Lin Z, Wang M, Lin H. Selective usage of isozymes for stress response. Acs Chemical Biology. PMID 30346689 DOI: 10.1021/Acschembio.8B00767  0.358
2018 Hong JY, Zhang X, Lin H. HPLC-Based Enzyme Assays for Sirtuins. Methods in Molecular Biology (Clifton, N.J.). 1813: 225-234. PMID 30097871 DOI: 10.1007/978-1-4939-8588-3_15  0.519
2018 Dong M, Zhang Y, Lin H. Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis. Methods in Enzymology. 606: 421-438. PMID 30097101 DOI: 10.1016/Bs.Mie.2018.04.001  0.377
2018 Spiegelman NA, Price IR, Jing H, Wang M, Yang M, Cao J, Hong JY, Zhang X, Aramsangtienchai P, Sadhukhan S, Lin H. Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-target Anticancer Activities. Chemmedchem. PMID 30058233 DOI: 10.1002/Cmdc.201800391  0.448
2018 Dong M, Zhang Y, Lin H. Non-canonical radical SAM enzyme chemistry learned from diphthamide biosynthesis. Biochemistry. PMID 29708734 DOI: 10.1021/Acs.Biochem.8B00287  0.379
2018 Dong M, Kathiresan V, Fenwick MK, Torelli AT, Zhang Y, Caranto JD, Dzikovski B, Sharma A, Lancaster KM, Freed JH, Ealick SE, Hoffman BM, Lin H. Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science (New York, N.Y.). 359: 1247-1250. PMID 29590073 DOI: 10.1126/Science.Aao6595  0.337
2018 Lin H, Caroll KS. Introduction: Posttranslational Protein Modification. Chemical Reviews. 118: 887-888. PMID 29439579 DOI: 10.1021/Acs.Chemrev.7B00756  0.318
2018 Zhang X, Cao J, Miller SP, Jing H, Lin H. Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b. Acs Central Science. 4: 71-80. PMID 29392178 DOI: 10.1021/Acscentsci.7B00440  0.462
2018 Jiang H, Zhang X, Chen X, Aramsangtienchai P, Tong Z, Lin H. Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies. Chemical Reviews. PMID 29292991 DOI: 10.1021/Acs.Chemrev.6B00750  0.464
2018 Latifkar A, Ling L, Zhang X, Fischbach C, Lin H, Cerione R, Antonyak M. Abstract 4506: Loss of SIRT1 alters the secretome of breast cancer cells by impairing lysosomal integrity Cancer Research. 78: 4506-4506. DOI: 10.1158/1538-7445.Am2018-4506  0.762
2017 Jing H, Zhang X, Wisner SA, Chen X, Spiegelman NA, Linder ME, Lin H. SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. Elife. 6. PMID 29239724 DOI: 10.7554/Elife.32436  0.452
2017 Zhang L, Lin H. Using Clickable NAD(+) Analogs to Label Substrate Proteins of PARPs. Methods in Molecular Biology (Clifton, N.J.). 1608: 95-109. PMID 28695506 DOI: 10.1007/978-1-4939-6993-7_8  0.42
2017 Zhang X, Spiegelman NA, Nelson OD, Jing H, Lin H. SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. Elife. 6. PMID 28406396 DOI: 10.7554/Elife.25158  0.418
2017 Dong M, Horitani M, Dzikovski B, Freed JH, Ealick S, Hoffman BM, Lin H. Substrate-Dependent Cleavage Site Selection by Unconventional Radical SAM Enzymes in Diphthamide Biosynthesis. Journal of the American Chemical Society. PMID 28383907 DOI: 10.1021/Jacs.7B01712  0.338
2017 Aramsangtienchai P, Spiegelman NA, Cao J, Lin H. S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. The Journal of Biological Chemistry. PMID 28196865 DOI: 10.1074/Jbc.M116.730523  0.307
2017 Wang ZA, Kurra Y, Wang X, Zeng Y, Lee YJ, Sharma V, Lin H, Dai SY, Liu WR. A Versatile Approach for Site-Specific Lysine Acylation in Proteins. Angewandte Chemie (International Ed. in English). PMID 28042700 DOI: 10.1002/Anie.201611415  0.381
2017 Jing H, Zhang X, Wisner SA, Chen X, Spiegelman NA, Linder ME, Lin H. Author response: SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a Elife. DOI: 10.7554/Elife.32436.026  0.404
2017 Zhang X, Spiegelman NA, Nelson OD, Jing H, Lin H. Author response: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation Elife. DOI: 10.7554/Elife.25158.019  0.397
2017 Li M, Chiang Y, Lyssiotis C, Teater M, Shen H, Wang L, Hong JY, Jin H, Duy C, Mistry S, Cerchietti L, Cross J, Cantley L, Lin H, Melnick A. SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls Blood. 130: 643-643. DOI: 10.1182/Blood.V130.Suppl_1.643.643  0.318
2016 Tong Z, Wang M, Wang Y, Kim DD, Grenier JK, Cao J, Sadhukhan S, Hao Q, Lin H. SIRT7 Is an RNA-Activated Protein Lysine Deacylase. Acs Chemical Biology. PMID 27997115 DOI: 10.1021/Acschembio.6B00954  0.348
2016 Lin Z, Dong M, Zhang Y, Lee EA, Lin H. Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification. Nature Chemical Biology. PMID 27694803 DOI: 10.1038/Nchembio.2190  0.395
2016 Jin J, He B, Lin H, Wang Y. SIRT2 reverses 4-oxononanoyl lysine modification on histones. Journal of the American Chemical Society. PMID 27610633 DOI: 10.1021/Jacs.6B04977  0.338
2016 Dong M, Horitani M, Dzikovski B, Pandelia ME, Krebs C, Freed JH, Hoffman BM, Lin H. An organometallic complex formed by an unconventional radical SAM enzyme. Journal of the American Chemical Society. PMID 27465315 DOI: 10.1021/Jacs.6B04155  0.334
2016 Aramsangtienchai P, Spiegelman NA, He B, Miller SP, Dai L, Zhao Y, Lin H. HDAC8 catalyzes the hydrolysis of long chain fatty acyl lysine. Acs Chemical Biology. PMID 27459069 DOI: 10.1021/Acschembio.6B00396  0.356
2016 Zhang X, Khan S, Jiang H, Antonyak MA, Chen X, Spiegelman NA, Shrimp JH, Cerione RA, Lin H. Identifying the functional contribution of the defatty-acylase activity of SIRT6. Nature Chemical Biology. PMID 27322069 DOI: 10.1038/Nchembio.2106  0.619
2016 Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science (New York, N.Y.). PMID 27256882 DOI: 10.1126/Science.Aaf7865  0.382
2016 Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H. A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell. 29: 767-768. PMID 27165747 DOI: 10.1016/J.Ccell.2016.04.005  0.553
2016 Bheda P, Jing H, Wolberger C, Lin H. The Substrate Specificity of Sirtuins. Annual Review of Biochemistry. PMID 27088879 DOI: 10.1146/Annurev-Biochem-060815-014537  0.364
2016 Jiang H, Zhang X, Lin H. Lysine fatty acylation promotes lysosomal targeting of TNF-α. Scientific Reports. 6: 24371. PMID 27079798 DOI: 10.1038/Srep24371  0.388
2016 Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H. A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell. 29: 607. PMID 27070708 DOI: 10.1016/j.ccell.2016.03.011  0.488
2016 Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H. Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proceedings of the National Academy of Sciences of the United States of America. PMID 27051063 DOI: 10.1073/Pnas.1519858113  0.342
2016 Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H. A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell. 29: 297-310. PMID 26977881 DOI: 10.1016/j.ccell.2016.02.007  0.5
2016 Tong Z, Wang Y, Zhang X, Kim DD, Sadhukhan S, Hao Q, Lin H. SIRT7 is activated by DNA and deacetylates histone H3 in the chromatin context. Acs Chemical Biology. PMID 26907567 DOI: 10.1021/Acschembio.5B01084  0.468
2016 Chiang YL, Lin H. An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3. Organic & Biomolecular Chemistry. PMID 26796034 DOI: 10.1039/C5Ob02609A  0.558
2015 Li Z, Kim DD, Nelson OD, Otwell AE, Richardson RE, Callister SJ, Lin H. Molecular dissection of a putative iron reductase from Desulfotomaculum reducens MI-1. Biochemical and Biophysical Research Communications. PMID 26454174 DOI: 10.1016/J.Bbrc.2015.10.016  0.317
2015 Jing H, Lin H. Sirtuins in epigenetic regulation. Chemical Reviews. 115: 2350-75. PMID 25804908 DOI: 10.1021/Cr500457H  0.376
2015 Teng YB, Jing H, Aramsangtienchai P, He B, Khan S, Hu J, Lin H, Hao Q. Efficient demyristoylase activity of SIRT2 revealed by kinetic and structural studies. Scientific Reports. 5: 8529. PMID 25704306 DOI: 10.1038/Srep08529  0.38
2015 Otwell AE, Sherwood RW, Zhang S, Nelson OD, Li Z, Lin H, Callister SJ, Richardson RE. Identification of proteins capable of metal reduction from the proteome of the Gram-positive bacterium Desulfotomaculum reducens MI-1 using an NADH-based activity assay. Environmental Microbiology. 17: 1977-90. PMID 25389064 DOI: 10.1111/1462-2920.12673  0.348
2014 He B, Hu J, Zhang X, Lin H. Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Organic & Biomolecular Chemistry. 12: 7498-502. PMID 25163004 DOI: 10.1039/C4Ob00860J  0.43
2014 Hu J, Jing H, Lin H. Sirtuin inhibitors as anticancer agents. Future Medicinal Chemistry. 6: 945-66. PMID 24962284 DOI: 10.4155/Fmc.14.44  0.396
2014 Lin Z, Su X, Chen W, Ci B, Zhang S, Lin H. Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. Journal of the American Chemical Society. 136: 6179-82. PMID 24739148 DOI: 10.1021/Ja5009272  0.549
2014 Shrimp JH, Hu J, Dong M, Wang BS, MacDonald R, Jiang H, Hao Q, Yen A, Lin H. Revealing CD38 cellular localization using a cell permeable, mechanism-based fluorescent small-molecule probe. Journal of the American Chemical Society. 136: 5656-63. PMID 24660829 DOI: 10.1021/Ja411046J  0.54
2014 Luo Q, Tang L, Lin H, Huang J, Zhang T, Liu Y, Wang J, Zhan P, Yin X, Su X, Ji Q, Yu D, Xu L. The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 84: 190-5. PMID 24636699 DOI: 10.1016/j.lungcan.2013.08.029  0.387
2014 Feng GD, Shi M, Ma L, Chen P, Wang BJ, Zhang M, Chang XL, Su XC, Yang YN, Fan XH, Dai W, Liu TT, He Y, Bian T, Duan LX, ... ... Lin H, et al. Diagnostic accuracy of intracellular mycobacterium tuberculosis detection for tuberculous meningitis. American Journal of Respiratory and Critical Care Medicine. 189: 475-81. PMID 24450377 DOI: 10.1164/rccm.201309-1686OC  0.366
2014 Dong M, Su X, Dzikovski B, Dando EE, Zhu X, Du J, Freed JH, Lin H. Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. Journal of the American Chemical Society. 136: 1754-7. PMID 24422557 DOI: 10.1021/Ja4118957  0.784
2013 Colak G, Xie Z, Zhu AY, Dai L, Lu Z, Zhang Y, Wan X, Chen Y, Cha YH, Lin H, Zhao Y, Tan M. Identification of lysine succinylation substrates and the succinylation regulatory enzyme CobB in Escherichia coli. Molecular & Cellular Proteomics : McP. 12: 3509-20. PMID 24176774 DOI: 10.1074/Mcp.M113.031567  0.422
2013 Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J. Metabolic characterization of a Sirt5 deficient mouse model. Scientific Reports. 3: 2806. PMID 24076663 DOI: 10.1038/Srep02806  0.313
2013 Zhu A, Su X, Lin H. Detecting sirtuin-catalyzed deacylation reactions using ³²P-labeled NAD and thin-layer chromatography. Methods in Molecular Biology (Clifton, N.J.). 1077: 179-89. PMID 24014407 DOI: 10.1007/978-1-62703-637-5_12  0.559
2013 Su X, Lin Z, Lin H. The biosynthesis and biological function of diphthamide. Critical Reviews in Biochemistry and Molecular Biology. 48: 515-21. PMID 23971743 DOI: 10.3109/10409238.2013.831023  0.516
2013 Hu J, He B, Bhargava S, Lin H. A fluorogenic assay for screening Sirt6 modulators. Organic & Biomolecular Chemistry. 11: 5213-6. PMID 23839075 DOI: 10.1039/C3Ob41138A  0.322
2013 Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, Hang HC, Hao Q, Lin H. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 496: 110-3. PMID 23552949 DOI: 10.1038/Nature12038  0.386
2013 Jiang H, Sherwood R, Zhang S, Zhu X, Liu Q, Graeff R, Kriksunov IA, Lee HC, Hao Q, Lin H. Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry. Analytical Biochemistry. 433: 218-26. PMID 23123429 DOI: 10.1016/J.Ab.2012.10.029  0.729
2012 Jiang H, Lin H. Labeling Substrate Proteins of Poly(ADP-ribose) Polymerases with Clickable NAD Analog. Current Protocols in Chemical Biology. 4: 19-34. PMID 23187903 DOI: 10.1002/9780470559277.Ch110196  0.382
2012 Su X, Lin Z, Chen W, Jiang H, Zhang S, Lin H. Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. Proceedings of the National Academy of Sciences of the United States of America. 109: 19983-7. PMID 23169644 DOI: 10.1073/Pnas.1214346109  0.525
2012 Zhou Y, Zhang H, He B, Du J, Lin H, Cerione RA, Hao Q. The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). The Journal of Biological Chemistry. 287: 28307-14. PMID 22767592 DOI: 10.1074/Jbc.M112.384511  0.536
2012 Lin H, Su X, He B. Protein lysine acylation and cysteine succination by intermediates of energy metabolism. Acs Chemical Biology. 7: 947-60. PMID 22571489 DOI: 10.1021/Cb3001793  0.532
2012 He B, Du J, Lin H. Thiosuccinyl peptides as Sirt5-specific inhibitors. Journal of the American Chemical Society. 134: 1922-5. PMID 22263694 DOI: 10.1021/Ja2090417  0.341
2012 Su X, Chen W, Lee W, Jiang H, Zhang S, Lin H. YBR246W is required for the third step of diphthamide biosynthesis. Journal of the American Chemical Society. 134: 773-6. PMID 22188241 DOI: 10.1021/Ja208870A  0.551
2012 Zhu AY, Zhou Y, Khan S, Deitsch KW, Hao Q, Lin H. Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine. Acs Chemical Biology. 7: 155-9. PMID 21992006 DOI: 10.1021/Cb200230X  0.344
2011 Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, ... ... Lin H, et al. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (New York, N.Y.). 334: 806-9. PMID 22076378 DOI: 10.1126/Science.1207861  0.667
2011 Lin H, Begley T. Protein posttranslational modifications: chemistry, biology, and applications. Molecular Biosystems. 7: 14-5. PMID 21107473 DOI: 10.1039/C0Mb90037K  0.475
2011 Zhu X, Dzikovski B, Su X, Torelli AT, Zhang Y, Ealick SE, Freed JH, Lin H. Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis. Molecular Biosystems. 7: 74-81. PMID 20931132 DOI: 10.1039/C0Mb00076K  0.78
2011 Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H. Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme (Nature (2010) 465 (891-896)) Nature. 473: 544. DOI: 10.1038/Nature10087  0.739
2010 Zhu X, Kim J, Su X, Lin H. Reconstitution of diphthine synthase activity in vitro. Biochemistry. 49: 9649-57. PMID 20873788 DOI: 10.1021/Bi100812H  0.792
2010 Jiang H, Kim JH, Frizzell KM, Kraus WL, Lin H. Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases. Journal of the American Chemical Society. 132: 9363-72. PMID 20560583 DOI: 10.1021/Ja101588R  0.389
2010 Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H. Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature. 465: 891-6. PMID 20559380 DOI: 10.1038/Nature09138  0.765
2009 Du J, Jiang H, Lin H. Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry. 48: 2878-90. PMID 19220062 DOI: 10.1021/Bi802093G  0.395
2008 Peralta-Yahya P, Carter BT, Lin H, Tao H, Cornish VW. High-throughput selection for cellulase catalysts using chemical complementation. Journal of the American Chemical Society. 130: 17446-52. PMID 19053460 DOI: 10.1021/Ja8055744  0.77
2008 Liu Q, Kriksunov IA, Jiang H, Graeff R, Lin H, Lee HC, Hao Q. Covalent and noncovalent intermediates of an NAD utilizing enzyme, human CD38. Chemistry & Biology. 15: 1068-78. PMID 18940667 DOI: 10.1016/J.Chembiol.2008.08.007  0.378
2008 Shi J, Wei PK, Zhang S, Qin ZF, Li J, Sun DZ, Xiao Y, Yu ZH, Lin HM, Zheng GJ, Su XM, Chen YL, Liu YF, Xu L. OB glue paste technique for establishing nude mouse human gastric cancer orthotopic transplantation models. World Journal of Gastroenterology. 14: 4800-4. PMID 18720543 DOI: 10.3748/wjg.14.4800  0.36
2007 Lin H. Nicotinamide adenine dinucleotide: beyond a redox coenzyme. Organic & Biomolecular Chemistry. 5: 2541-54. PMID 18019526 DOI: 10.1039/B706887E  0.303
2006 Luo M, Lin H, Fischbach MA, Liu DR, Walsh CT, Groves JT. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. Acs Chemical Biology. 1: 29-32. PMID 17163637 DOI: 10.1021/Cb0500034  0.618
2006 Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proceedings of the National Academy of Sciences of the United States of America. 103: 16502-7. PMID 17060628 DOI: 10.1073/Pnas.0604636103  0.627
2006 Larsen NA, Lin H, Wei R, Fischbach MA, Walsh CT. Structural characterization of enterobactin hydrolase IroE. Biochemistry. 45: 10184-90. PMID 16922493 DOI: 10.1021/bi060950i  0.62
2006 Tao H, Peralta-Yahya P, Lin H, Cornish VW. Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation. Bioorganic & Medicinal Chemistry. 14: 6940-53. PMID 16870451 DOI: 10.1016/J.Bmc.2006.06.034  0.787
2006 Lin H, Fischbach MA, Gatto GJ, Liu DR, Walsh CT. Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. Journal of the American Chemical Society. 128: 9324-5. PMID 16848455 DOI: 10.1021/Ja063236X  0.633
2006 Fischbach MA, Lin H, Liu DR, Walsh CT. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nature Chemical Biology. 2: 132-8. PMID 16485005 DOI: 10.1038/Nchembio771  0.639
2005 Carter BT, Lin H, Goldberg SD, Althoff EA, Raushel J, Cornish VW. Investigation of the mechanism of resistance to third-generation cephalosporins by class C beta-lactamases by using chemical complementation. Chembiochem : a European Journal of Chemical Biology. 6: 2055-67. PMID 16250067 DOI: 10.1002/Cbic.200500058  0.748
2005 Lin H, Fischbach MA, Liu DR, Walsh CT. In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. Journal of the American Chemical Society. 127: 11075-84. PMID 16076215 DOI: 10.1021/Ja0522027  0.634
2005 Fischbach MA, Lin H, Liu DR, Walsh CT. In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 571-6. PMID 15598734 DOI: 10.1073/Pnas.0408463102  0.613
2004 Lin H, Thayer DA, Wong CH, Walsh CT. Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase. Chemistry & Biology. 11: 1635-42. PMID 15610847 DOI: 10.1016/J.Chembiol.2004.09.015  0.437
2004 Yeh E, Lin H, Clugston SL, Kohli RM, Walsh CT. Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent. Chemistry & Biology. 11: 1573-82. PMID 15556008 DOI: 10.1016/J.Chembiol.2004.09.003  0.741
2004 Lin H, Tao H, Cornish VW. Directed evolution of a glycosynthase via chemical complementation. Journal of the American Chemical Society. 126: 15051-9. PMID 15548001 DOI: 10.1021/Ja046238V  0.73
2004 Lin H, Walsh CT. A chemoenzymatic approach to glycopeptide antibiotics. Journal of the American Chemical Society. 126: 13998-4003. PMID 15506762 DOI: 10.1021/Ja045147V  0.467
2004 Sengupta D, Lin H, Goldberg SD, Mahal JJ, Cornish VW. Correlation between catalytic efficiency and the transcription read-out in chemical complementation: a general assay for enzyme catalysis. Biochemistry. 43: 3570-81. PMID 15035627 DOI: 10.1021/Bi035810C  0.8
2003 Forster AC, Tan Z, Nalam MN, Lin H, Qu H, Cornish VW, Blacklow SC. Programming peptidomimetic syntheses by translating genetic codes designed de novo. Proceedings of the National Academy of Sciences of the United States of America. 100: 6353-7. PMID 12754376 DOI: 10.1073/Pnas.1132122100  0.679
2002 Baker K, Bleczinski C, Lin H, Salazar-Jimenez G, Sengupta D, Krane S, Cornish VW. Chemical complementation: a reaction-independent genetic assay for enzyme catalysis. Proceedings of the National Academy of Sciences of the United States of America. 99: 16537-42. PMID 12482929 DOI: 10.1073/Pnas.262420099  0.734
2002 Lin H, Cornish VW. Screening and selection methods for large-scale analysis of protein function. Angewandte Chemie (International Ed. in English). 41: 4402-25. PMID 12458502 DOI: 10.1002/1521-3773(20021202)41:23<4402::Aid-Anie4402>3.0.Co;2-H  0.635
2002 Abida WM, Carter BT, Althoff EA, Lin H, Cornish VW. Receptor-dependence of the transcription read-out in a small-molecule three-hybrid system. Chembiochem : a European Journal of Chemical Biology. 3: 887-95. PMID 12210990 DOI: 10.1002/1439-7633(20020902)3:9<887::Aid-Cbic887>3.0.Co;2-F  0.765
2002 Lin H, Cornish VW. Screening- und Selektionsmethoden für die Analyse von Proteinfunktionen in großem Maßstab Angewandte Chemie. 114: 4580-4606. DOI: 10.1002/1521-3757(20021202)114:23<4580::Aid-Ange4580>3.0.Co;2-P  0.6
2001 Lin H, Cornish VW. In Vivo Protein-Protein Interaction Assays: Beyond Proteins. Angewandte Chemie (International Ed. in English). 40: 871-875. PMID 29712174 DOI: 10.1002/1521-3773(20010302)40:5<871::Aid-Anie871>3.0.Co;2-S  0.621
2001 Lin H, Cornish VW. In Vivo Protein-Protein Interaction Assays: Beyond Proteins We would like to thank Tony Siu, Dr. Charles Cho, and the members of our lab for their helpful comments as we were preparing this manuscript. Angewandte Chemie (International Ed. in English). 40: 871-875. PMID 11241632 DOI: 10.1002/1521-3773(20010302)40:5<871::AID-ANIE871>3.0.CO;2-S  0.578
2001 Lin H, Cornish VW. In-vivo-Testsysteme für Protein-Protein-Wechselwirkungen: eine Methode nicht nur für Proteine Angewandte Chemie. 113: 895-899. DOI: 10.1002/1521-3757(20010302)113:5<895::Aid-Ange895>3.0.Co;2-L  0.602
2000 Lin H, Abida WM, Sauer RT, Cornish VW. Dexamethasone-methotrexate: An efficient chemical inducer of protein dimerization in vivo [18] Journal of the American Chemical Society. 122: 4247-4248. DOI: 10.1021/Ja9941532  0.684
1999 Zhao G, Lin H, Yu P, Sun H, Zhu S, Su X, Chen Y. Ethylenediamine-palladium(II) complexes with pyridine and its derivatives: synthesis, molecular structure and initial antitumor studies. Journal of Inorganic Biochemistry. 73: 145-9. PMID 10331244  0.368
1998 Zhao G, Sun H, Lin H, Zhu S, Su X, Chen Y. Palladium(II) complexes with N,N'-dialkyl-1,10-phenanthroline-2,9-dimathanamine: synthesis, characterization and cytotoxic activity. Journal of Inorganic Biochemistry. 72: 173-7. PMID 10065535  0.361
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