Manohar Ratnam - Publications

Affiliations: 
College of Medicine The University of Toledo 
Area:
Molecular Biology, Biochemistry, Oncology

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rosati R, Oppat K, Huang Y, Kim S, Ratnam M. Clinical association of progesterone receptor isoform A with breast cancer metastasis consistent with its unique mechanistic role in preclinical models. Bmc Cancer. 20: 512. PMID 32493230 DOI: 10.1186/s12885-020-07002-0  0.56
2020 Purrington KS, Gorski D, Simon MS, Hastert TA, Kim S, Rosati R, Schwartz AG, Ratnam M. Racial differences in estrogen receptor staining levels and implications for treatment and survival among estrogen receptor positive, HER2-negative invasive breast cancers. Breast Cancer Research and Treatment. PMID 32236827 DOI: 10.1007/s10549-020-05607-4  0.32
2019 Pardy L, Rosati R, Soave C, Huang Y, Kim S, Ratnam M. The ternary complex factor protein ELK1 is an independent prognosticator of disease recurrence in prostate cancer. The Prostate. PMID 31794091 DOI: 10.1002/pros.23932  0.56
2018 Patki M, McFall T, Rosati R, Huang Y, Malysa A, Polin L, Fielder A, Wilson MR, Lonardo F, Back J, Li J, Matherly LH, Bepler G, Ratnam M. Chronic p27 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. Scientific Reports. 8: 16006. PMID 30375484 DOI: 10.1038/s41598-018-34475-8  0.84
2018 Rosati R, Polin LA, Ducker C, Li J, Bao X, Selvakumar D, Kim S, Xhabija B, Larsen M, McFall T, Huang Y, Kidder BL, Fribley A, Saxton J, Kakuta H, ... ... Ratnam M, et al. Strategy for Tumor Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30185422 DOI: 10.1158/1078-0432.CCR-18-0982  0.56
2017 McFall T, McKnight B, Rosati R, Kim S, Huang Y, Viola-Villegas N, Ratnam M. Progesterone Receptor A Promotes Invasiveness and Metastasis of Luminal Breast Cancer by Suppressing Regulation of Critical Micro RNAs by Estrogen. The Journal of Biological Chemistry. PMID 29162724 DOI: 10.1074/jbc.M117.812438  0.56
2016 Rosati R, Patki M, Chari V, Dakshnamurthy S, McFall T, Saxton J, Kidder BL, Shaw PE, Ratnam M. The Amino-terminal Domain of the Androgen Receptor Co-opts ERK Docking Sites in ELK1 to Induce Sustained Gene Activation that Supports Prostate Cancer Cell Growth. The Journal of Biological Chemistry. PMID 27793987 DOI: 10.1074/jbc.M116.745596  0.84
2016 Rosati R, Chen B, Patki M, McFall T, Ou S, Heath E, Ratnam M, Qin Z. Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease HSP90 and the Androgen Receptor Levels and Inhibit Viability in Enzalutamide Resistant C4-2 Prostate Cancer Cells. Molecular Pharmacology. PMID 27382012 DOI: 10.1124/mol.116.103416  0.84
2016 Patki M, Huang Y, Ratnam M. Restoration of the cellular secretory milieu overrides androgen dependence of in vivo generated castration resistant prostate cancer cells overexpressing the androgen receptor. Biochemical and Biophysical Research Communications. PMID 27179779 DOI: 10.1016/j.bbrc.2016.05.058  0.84
2016 Wilson MR, Hou Z, Yang S, Polin L, Kushner J, White K, Huang J, Ratnam M, Gangjee A, Matherly LH. Targeting Non-Squamous Non-Small Cell Lung Cancer Via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates. Molecular Pharmacology. PMID 26837243 DOI: 10.1124/mol.115.102798  0.76
2015 McFall T, Patki M, Rosati R, Ratnam M. Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges. Oncotarget. 6: 33146-64. PMID 26356672 DOI: 10.18632/oncotarget.5082  0.84
2015 Patki M, Salazar Md, Trumbly R, Ratnam M. Differential effects of estrogen-dependent transactivation vs. transrepression by the estrogen receptor on invasiveness of HER2 overexpressing breast cancer cells. Biochemical and Biophysical Research Communications. 457: 404-11. PMID 25582774 DOI: 10.1016/j.bbrc.2015.01.004  0.84
2014 Patki M, Gadgeel S, Huang Y, McFall T, Shields AF, Matherly LH, Bepler G, Ratnam M. Glucocorticoid receptor status is a principal determinant of variability in the sensitivity of non-small-cell lung cancer cells to pemetrexed Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 519-526. PMID 24736075 DOI: 10.1097/JTO.0000000000000111  0.76
2014 Shen M, Zhang Z, Ratnam M, Dou QP. The interplay of AMP-activated protein kinase and androgen receptor in prostate cancer cells. Journal of Cellular Physiology. 229: 688-95. PMID 24129850 DOI: 10.1002/jcp.24494  0.76
2013 Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, Ratnam M, Zhang F, Dann CE. Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proceedings of the National Academy of Sciences of the United States of America. 110: 15180-8. PMID 23934049 DOI: 10.1073/pnas.1308827110  0.76
2013 Jetson R, Malik N, Luniwal A, Chari V, Ratnam M, Erhardt P. Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound European Journal of Medicinal Chemistry. 63: 104-108. PMID 23474897 DOI: 10.1016/j.ejmech.2013.02.012  0.76
2013 Patki M, Chari V, Sivakumaran S, Gonit M, Trumbly R, Ratnam M. The ETS domain transcription factor ELK1 directs a critical component of growth signaling by the androgen receptor in prostate cancer cells Journal of Biological Chemistry. 288: 11047-11065. PMID 23426362 DOI: 10.1074/jbc.M112.438473  0.76
2012 Jaiswal N, Saraswat S, Ratnam M, Isailovic D. Analysis of folate binding protein N-linked glycans by mass spectrometry. Journal of Proteome Research. 11: 1551-60. PMID 22191536 DOI: 10.1021/pr2006044  0.76
2011 Gonit M, Zhang J, d'Alincourt Salazar M, Cui H, Shatnawi A, Trumbly R, Ratnam M. Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements Molecular Endocrinology. 25: 621-634. PMID 21330406 DOI: 10.1210/me.2010-0409  0.76
2011 Salazar MD, Ratnam M, Patki M, Kisovic I, Trumbly R, Iman M. During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein Breast Cancer Research. 13. PMID 21299862 DOI: 10.1186/bcr2827  0.8
2010 Li H, Lu Y, Piao L, Wu J, Liu S, Marcucci G, Ratnam M, Lee RJ. Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid International Journal of Pharmaceutics. 402: 57-63. PMID 20883757 DOI: 10.1016/j.ijpharm.2010.09.019  0.76
2010 Sivakumaran S, Zhang J, Kelley KM, Gonit M, Hao H, Ratnam M. Androgen activation of the folate receptor α gene through partial tethering of the androgen receptor by C/EBPα. The Journal of Steroid Biochemistry and Molecular Biology. 122: 333-40. PMID 20817090 DOI: 10.1016/j.jsbmb.2010.08.008  0.76
2010 Zhang J, Gonit M, Salazar MD, Shatnawi A, Shemshedini L, Trumbly R, Ratnam M. C/EBPα redirects androgen receptor signaling through a unique bimodal interaction Oncogene. 29: 723-738. PMID 19901962 DOI: 10.1038/onc.2009.373  0.76
2009 Puig-Kröger A, Sierra-Filardi E, Domínguez-Soto A, Samaniego R, Corcuera MT, Gómez-Aguado F, Ratnam M, Sánchez-Mateos P, Corbí AL. Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. Cancer Research. 69: 9395-403. PMID 19951991 DOI: 10.1158/0008-5472.CAN-09-2050  0.76
2009 Elnakat H, Gonit M, Salazar MDA, Zhang J, Basrur V, Gunning W, Kamen B, Ratnam M. Regulation of folate receptor internalization by protein kinase C Biochemistry. 48: 8249-8260. PMID 19639961 DOI: 10.1021/bi900565t  0.76
2009 Van Der Heijden JW, Oerlemans R, Dijkmans BAC, Qi H, Van Der Laken CJ, Lems WF, Jackman AL, Kraan MC, Tak PP, Ratnam M, Jansen G. Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients Arthritis and Rheumatism. 60: 12-21. PMID 19116913 DOI: 10.1002/art.24219  0.76
2008 Zhang J, Wilkinson JE, Gonit M, Keck R, Selman S, Ratnam M. Expression and sub-cellular localization of the CCAAT/enhancer binding protein α in relation to postnatal development and malignancy of the prostate Prostate. 68: 1206-1214. PMID 18481268 DOI: 10.1002/pros.20779  0.76
2007 Lu Y, Wu J, Wu J, Gonit M, Yang X, Lee A, Xiang G, Li H, Liu S, Marcucci G, Ratnam M, Lee RJ. Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells. Molecular Pharmaceutics. 4: 707-12. PMID 17708654 DOI: 10.1021/mp070058l  0.76
2007 Blaser BW, Gonit M, Qi H, Shatnawi A, Guimond M, Lee RJ, Ratnam M. Induction of folate receptor type β in a bone marrow engraftment model of acute myelogenous leukemia [22] Leukemia. 21: 2233-2235. PMID 17554378 DOI: 10.1038/sj.leu.2404786  0.76
2007 Salazar MDA, Ratnam M. The folate receptor: What does it promise in tissue-targeted therapeutics? Cancer and Metastasis Reviews. 26: 141-152. PMID 17333345 DOI: 10.1007/s10555-007-9048-0  0.76
2007 Shatnawi A, Tran T, Ratnam M. R5020 and RU486 act as progesterone receptor agonists to enhance Sp1/Sp4-dependent gene transcription by an indirect mechanism Molecular Endocrinology. 21: 635-650. PMID 17192405 DOI: 10.1210/me.2006-0274  0.76
2006 Qi H, Ratnam M. Synergistic induction of folate receptor β by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: Mechanism and utility in enhancing selective growth inhibition by antifolates Cancer Research. 66: 5875-5882. PMID 16740727 DOI: 10.1158/0008-5472.CAN-05-4048  0.76
2006 Elnakat H, Ratnam M. Role of folate receptor genes in reproduction and related cancers Frontiers in Bioscience. 11: 506-519. PMID 16146749 DOI: 10.2741/1815  0.76
2005 Tran T, Shatnawi A, Zheng X, Kelley KM, Ratnam M. Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. Cancer Research. 65: 4431-41. PMID 15899836 DOI: 10.1158/0008-5472.CAN-04-2890  0.4
2004 Elnakat H, Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Advanced Drug Delivery Reviews. 56: 1067-84. PMID 15094207 DOI: 10.1016/j.addr.2004.01.001  0.32
2003 Ratnam M, Hao H, Zheng X, Wang H, Qi H, Lee R, Pan X. Receptor induction and targeted drug delivery: a new antileukaemia strategy. Expert Opinion On Biological Therapy. 3: 563-74. PMID 12831362 DOI: 10.1517/14712598.3.4.563  0.56
2003 Zheng X, Kelley K, Elnakat H, Yan W, Dorn T, Ratnam M. mRNA instability in the nucleus due to a novel open reading frame element is a major determinant of the narrow tissue specificity of folate receptor alpha. Molecular and Cellular Biology. 23: 2202-12. PMID 12612090 DOI: 10.1128/MCB.23.6.2202-2212.2003  0.76
2003 Hao H, Qi H, Ratnam M. Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. Blood. 101: 4551-60. PMID 12543860 DOI: 10.1182/blood-2002-10-3174  0.56
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