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Gabriele Ludewig - Publications

Affiliations: 
Human Toxicology University of Iowa, Iowa City, IA 
Area:
Toxicology, Biochemistry, Environmental Health
Website:
https://www.public-health.uiowa.edu/people/gabriele-ludewig/
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37/64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Eti NA, Flor S, Iqbal K, Scott RL, Klenov VE, Gibson-Corley KN, Soares MJ, Ludewig G, Robertson LW. PCB126 Induced Toxic Actions on Liver Energy Metabolism is Mediated by AhR in Rats. Toxicology. 153054. PMID 34848246 DOI: 10.1016/j.tox.2021.153054  0.415
2021 Klenov V, Flor S, Ganesan S, Adur M, Eti N, Iqbal K, Soares MJ, Ludewig G, Ross JW, Robertson LW, Keating AF. The Aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats. Toxicology and Applied Pharmacology. 115639. PMID 34256052 DOI: 10.1016/j.taap.2021.115639  0.383
2018 Klenov V, Flor S, Ganesan S, Clark K, Eti N, Iqbal K, Soares M, Ludewig G, Keating A, Robertson L. Ovarian toxicity following exposure to polychlorinated biphenyl 126 is mediated by the aryl hydrocarbon receptor Fertility and Sterility. 110: e53. DOI: 10.1016/J.Fertnstert.2018.07.165  0.339
2017 Enayah SH, Vanle BC, Fuortes LJ, Doorn JA, Ludewig G. PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells. Toxicology. 394: 93-101. PMID 29233657 DOI: 10.1016/J.Tox.2017.12.003  0.388
2017 Dhakal K, Gadupudi GS, Lehmler HJ, Ludewig G, Duffel MW, Robertson LW. Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environmental Science and Pollution Research International. PMID 28744683 DOI: 10.1007/S11356-017-9694-X  0.374
2016 Klaren WD, Flor S, Gibson-Corley KN, Ludewig G, Robertson LW. Metallothionein's role in PCB126 induced hepatotoxicity and hepatic micronutrient disruption. Toxicology Reports. 3: 21-28. PMID 26770886 DOI: 10.1016/J.Toxrep.2015.12.001  0.466
2015 Wang B, Klaren WD, Wels BR, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. Dietary manganese modulates PCB126 toxicity, metal status and MnSOD in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26660635 DOI: 10.1093/Toxsci/Kfv312  0.732
2015 Xin X, Senthilkumar PK, Schnoor JL, Ludewig G. Effects of PCB126 and PCB153 on telomerase activity and telomere length in undifferentiated and differentiated HL-60 cells. Environmental Science and Pollution Research International. PMID 26330309 DOI: 10.1007/S11356-015-5187-Y  0.319
2015 Flor S, He X, Lehmler HJ, Ludewig G. Estrogenicity and androgenicity screening of PCB sulfate monoesters in human breast cancer MCF-7 cells. Environmental Science and Pollution Research International. PMID 26300354 DOI: 10.1007/S11356-015-5142-Y  0.367
2015 Shen H, Robertson LW, Ludewig G. Regulatory effects of dioxin-like and non-dioxin-like PCBs and other AhR ligands on the antioxidant enzymes paraoxonase 1/2/3. Environmental Science and Pollution Research International. PMID 26006071 DOI: 10.1007/S11356-015-4722-1  0.663
2015 Gadupudi G, Gourronc FA, Ludewig G, Robertson LW, Klingelhutz AJ. PCB126 inhibits adipogenesis of human preadipocytes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 29: 132-41. PMID 25304490 DOI: 10.1016/J.Tiv.2014.09.015  0.343
2014 Aqil F, Shen H, Jeyabalan J, Xin X, Lehmler HJ, Ludewig G, Robertson LW, Gupta RC. Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants. Toxicology Reports. 1: 820-833. PMID 25530946 DOI: 10.1016/J.Toxrep.2014.09.010  0.61
2014 Kim JS, Klösener J, Flor S, Peters TM, Ludewig G, Thorne PS, Robertson LW, Luthe G. Toxicity assessment of air-delivered particle-bound polybrominated diphenyl ethers. Toxicology. 317: 31-9. PMID 24451063 DOI: 10.1016/J.Tox.2014.01.005  0.342
2014 Shen H, Li M, Wang B, Lai IK, Robertson LW, Ludewig G. Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Environmental Science and Pollution Research International. 21: 6384-99. PMID 23644946 DOI: 10.1007/S11356-013-1690-1  0.754
2013 Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek WM, Wang K, Ludewig G, Robertson LW. Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver? Chemical Research in Toxicology. 26: 634-44. PMID 23527585 DOI: 10.1021/Tx400049S  0.516
2012 Lai IK, Dhakal K, Gadupudi GS, Li M, Ludewig G, Robertson LW, Olivier AK. N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents. Toxicology. 302: 25-33. PMID 22824115 DOI: 10.1016/J.Tox.2012.07.007  0.517
2012 Shen H, Robertson LW, Ludewig G. Regulation of paraoxonase 1 (PON1) in PCB 126-exposed male Sprague Dawley rats. Toxicology Letters. 209: 291-8. PMID 22266287 DOI: 10.1016/J.Toxlet.2012.01.003  0.637
2011 Senthilkumar PK, Robertson LW, Ludewig G. PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK). Toxicology and Applied Pharmacology. 259: 115-23. PMID 22210444 DOI: 10.1016/J.Taap.2011.12.015  0.346
2011 Wang B, Robertson LW, Wang K, Ludewig G. Species difference in the regulation of cytochrome P450 2S1: lack of induction in rats by the aryl hydrocarbon receptor agonist PCB126. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 1031-43. PMID 21970748 DOI: 10.3109/00498254.2011.603763  0.735
2011 Lai IK, Chai Y, Simmons D, Watson WH, Tan R, Haschek WM, Wang K, Wang B, Ludewig G, Robertson LW. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 202-14. PMID 21865291 DOI: 10.1093/Toxsci/Kfr215  0.759
2011 Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicology Letters. 204: 64-70. PMID 21530622 DOI: 10.1016/J.Toxlet.2011.04.012  0.347
2010 Jacobus JA, Wang B, Maddox C, Esch H, Lehmann L, Robertson LW, Wang K, Kirby P, Ludewig G. 3-Methylcholanthrene (3-MC) and 4-chlorobiphenyl (PCB3) genotoxicity is gender-related in Fischer 344 transgenic rats. Environment International. 36: 970-9. PMID 20739065 DOI: 10.1016/J.Envint.2010.07.006  0.733
2010 Flor S, Ludewig G. Polyploidy-induction by dihydroxylated monochlorobiphenyls: structure-activity-relationships. Environment International. 36: 962-9. PMID 20471090 DOI: 10.1016/J.Envint.2010.03.012  0.395
2010 Xie W, Wang K, Robertson LW, Ludewig G. Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites. Environment International. 36: 950-61. PMID 20129669 DOI: 10.1016/J.Envint.2009.12.004  0.38
2010 Lai I, Chai Y, Simmons D, Luthe G, Coleman MC, Spitz D, Haschek WM, Ludewig G, Robertson LW. Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status. Environment International. 36: 918-23. PMID 19969354 DOI: 10.1016/J.Envint.2009.11.002  0.545
2010 Ptak A, Ludewig G, Rak A, Nadolna W, Bochenek M, Gregoraszczuk EL. Induction of cytochrome P450 1A1 in MCF-7 human breast cancer cells by 4-chlorobiphenyl (PCB3) and the effects of its hydroxylated metabolites on cellular apoptosis. Environment International. 36: 935-41. PMID 19604582 DOI: 10.1016/J.Envint.2009.06.012  0.382
2009 Suh YW, Buettner GR, Venkataraman S, Treimer SE, Robertson LW, Ludewig G. UVA/B-induced formation of free radicals from decabromodiphenyl ether. Environmental Science & Technology. 43: 2581-8. PMID 19452920 DOI: 10.1021/Es8022978  0.597
2008 Ludewig G, Lehmann L, Esch H, Robertson LW. Metabolic Activation of PCBs to Carcinogens in Vivo - A Review. Environmental Toxicology and Pharmacology. 25: 241-6. PMID 18452002 DOI: 10.1016/J.Etap.2007.10.029  0.518
2008 Jacobus JA, Flor S, Klingelhutz A, Robertson LW, Ludewig G. 2-(4'-CHLOROPHENYL)-1,4-BENZOQUINONE INCREASES THE FREQUENCY OF MICRONUCLEI AND SHORTENS TELOMERES. Environmental Toxicology and Pharmacology. 25: 267-272. PMID 18438462 DOI: 10.1016/J.Etap.2007.10.022  0.342
2008 Maddox C, Wang B, Kirby PA, Wang K, Ludewig G. Mutagenicity of 3-methylcholanthrene, pcb3, and 4-oh-pcb3 in the lung of transgenic bigblue rats. Environmental Toxicology and Pharmacology. 25: 260-6. PMID 18438460 DOI: 10.1016/J.Etap.2007.10.021  0.713
2007 Zettner MA, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster v79 cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 100: 88-98. PMID 17686921 DOI: 10.1093/Toxsci/Kfm204  0.391
2007 Lehmann L, Esch HL, Kirby PA, Robertson LW, Ludewig G. 4-monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis. 28: 471-8. PMID 16950798 DOI: 10.1093/Carcin/Bgl157  0.488
2006 Ptak A, Ludewig G, Kapiszewska M, Magnowska Z, Lehmler HJ, Robertson LW, Gregoraszczuk EL. Induction of cytochromes P450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicology Letters. 166: 200-11. PMID 16949219 DOI: 10.1016/J.Toxlet.2006.07.304  0.4
2006 Bender RP, Lehmler HJ, Robertson LW, Ludewig G, Osheroff N. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry. 45: 10140-52. PMID 16906772 DOI: 10.1021/Bi0524666  0.344
2006 Ptak A, Ludewig G, Robertson L, Lehmler HJ, Gregoraszczuk EL. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity. Toxicology Letters. 164: 113-22. PMID 16412591 DOI: 10.1016/J.Toxlet.2005.12.001  0.402
2005 Ptak A, Ludewig G, Lehmler HJ, Wójtowicz AK, Robertson LW, Gregoraszczuk EL. Comparison of the actions of 4-chlorobiphenyl and its hydroxylated metabolites on estradiol secretion by ovarian follicles in primary cells in culture. Reproductive Toxicology (Elmsford, N.Y.). 20: 57-64. PMID 15808786 DOI: 10.1016/J.Reprotox.2004.12.003  0.331
1998 Espandiari P, Ludewig G, Glauert HP, Robertson LW. Activation of hepatic NF-kappaB by the herbicide Dicamba (2-methoxy-3,6-dichlorobenzoic acid) in female and male rats. Journal of Biochemical and Molecular Toxicology. 12: 339-44. PMID 9736482 DOI: 10.1002/(Sici)1099-0461(1998)12:6<339::Aid-Jbt3>3.0.Co;2-N  0.34
Low-probability matches (unlikely to be authored by this person)
2008 Gregoraszczuk EL, Rak A, Ludewig G, Gasińska A. Effects of estradiol, PCB3, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells. Environmental Toxicology and Pharmacology. 25: 227-33. PMID 21783862 DOI: 10.1016/J.Etap.2007.10.004  0.299
2013 Ludewig G, Robertson LW. Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma. Cancer Letters. 334: 46-55. PMID 23211541 DOI: 10.1016/J.Canlet.2012.11.041  0.297
2008 Lehmler HJ, Xu L, Vyas SM, Ojogun VA, Knutson BL, Ludewig G. Synthesis, physicochemical properties and in vitro cytotoxicity of nicotinic acid ester prodrugs intended for pulmonary delivery using perfluorooctyl bromide as vehicle. International Journal of Pharmaceutics. 353: 35-44. PMID 18164563 DOI: 10.1016/J.Ijpharm.2007.11.011  0.289
2017 Roh T, Lynch CF, Weyer P, Wang K, Kelly KM, Ludewig G. Low-level arsenic exposure from drinking water is associated with prostate cancer in Iowa. Environmental Research. 159: 338-343. PMID 28841521 DOI: 10.1016/J.Envres.2017.08.026  0.285
2015 Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, Duffel MW, Bergman Å, Robertson LW. Metabolism and metabolites of polychlorinated biphenyls. Critical Reviews in Toxicology. 45: 245-72. PMID 25629923 DOI: 10.3109/10408444.2014.999365  0.273
2020 Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov VE, Stolwijk JM, Lehmler HJ, Hornbuckle KC, Ludewig G, Robertson LW, Thorne PS. Comprehensive Subchronic Inhalation Toxicity Assessment of an Indoor School Air Mixture of PCBs. Environmental Science & Technology. PMID 33256405 DOI: 10.1021/acs.est.0c04470  0.27
2010 Xie W, Ludewig G, Wang K, Lehmler HJ. Model and cell membrane partitioning of perfluorooctanesulfonate is independent of the lipid chain length. Colloids and Surfaces. B, Biointerfaces. 76: 128-36. PMID 19932010 DOI: 10.1016/J.Colsurfb.2009.10.025  0.263
2015 Li M, Teesch LM, Murry DJ, Pope RM, Li Y, Robertson LW, Ludewig G. Cytochrome c adducts with PCB quinoid metabolites. Environmental Science and Pollution Research International. PMID 26062463 DOI: 10.1007/S11356-015-4801-3  0.261
2002 Srinivasan A, Robertson LW, Ludewig G. Sulfhydryl binding and topoisomerase inhibition by PCB metabolites. Chemical Research in Toxicology. 15: 497-505. PMID 11952335 DOI: 10.1021/TX010128+  0.246
2011 Robertson LW, Ludewig G. Polychlorinated Biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs. Gefahrstoffe, Reinhaltung Der Luft = Air Quality Control / Herausgeber, Bia Und Krdl Im Vdi Und Din. 71: 25-32. PMID 21686028  0.241
2001 Srinivasan A, Lehmler HJ, Robertson LW, Ludewig G. Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites. Toxicological Sciences : An Official Journal of the Society of Toxicology. 60: 92-102. PMID 11222876 DOI: 10.1093/Toxsci/60.1.92  0.226
2019 Klenov V, Flor S, Adur M, Ganesan S, Eti N, Iqbal K, Soares M, Ludewig G, Ross J, Keating A, Robertson L. Uterine toxicity following exposure to polychlorinated biphenyl 126 is mediated by the aryl hydrocarbon receptor Fertility and Sterility. 111: e4. DOI: 10.1016/j.fertnstert.2019.02.038  0.222
2005 Kania-Korwel I, Hornbuckle KC, Peck A, Ludewig G, Robertson LW, Sulkowski WW, Espandiari P, Gairola CG, Lehmler HJ. Congener-specific tissue distribution of aroclor 1254 and a highly chlorinated environmental PCB mixture in rats. Environmental Science & Technology. 39: 3513-20. PMID 15954224 DOI: 10.1021/Es047987F  0.215
2022 Zhang CY, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler HJ. Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites. Environmental Science & Technology. 56: 12460-12472. PMID 35994059 DOI: 10.1021/acs.est.2c03687  0.205
2005 Kodavanti PRS, Ward TR, Ludewig G, Robertson LW, Birnbaum LS. Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships Toxicological Sciences. 88: 181-192. PMID 16107548 DOI: 10.1093/Toxsci/Kfi289  0.198
2020 Zhang CY, Flor S, Ruiz P, Dhakal R, Hu X, Teesch LM, Ludewig G, Lehmler HJ. 3,3'-Dichlorobiphenyl is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells. Environmental Science & Technology. PMID 32910851 DOI: 10.1021/Acs.Est.0C03476  0.195
2021 Zhang CY, Flor S, Ruiz P, Ludewig G, Lehmler HJ. Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metabolite Profiles of Its Hydroxylated Metabolites. Environmental Science & Technology. PMID 34125531 DOI: 10.1021/acs.est.1c01076  0.186
2004 Xu Y, Fang F, Ludewig G, Jones G, Jones D. A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells. Dna and Cell Biology. 23: 527-37. PMID 15383173 DOI: 10.1089/dna.2004.23.527  0.176
2004 Xu Y, Fang F, Ludewig G, Jones G, Jones D. A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells. Dna and Cell Biology. 23: 419-29. PMID 15294091 DOI: 10.1089/1044549041474788  0.176
1999 Xu Y, Krishnan A, Wan XS, Majima H, Yeh CC, Ludewig G, Kasarskis EJ, St Clair DK. Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells. Oncogene. 18: 93-102. PMID 9926924 DOI: 10.1038/sj.onc.1202265  0.167
2008 Luthe G, Garcia Boy R, Jacobus J, Smith BJ, Rahaman A, Robertson LW, Ludewig G. Xenobiotic geometry and media pH determine cytotoxicity through solubility. Chemical Research in Toxicology. 21: 1017-27. PMID 18402468 DOI: 10.1021/Tx700214P  0.143
2020 Zhang CY, Flor S, Ludewig G, Lehmler HJ. Atropselective Partitioning of Polychlorinated Biphenyls in a HepG2 Cell Culture System: Experimental and Modeling Results. Environmental Science & Technology. 54: 13817-13827. PMID 33059451 DOI: 10.1021/acs.est.0c02508  0.14
2003 Tampal NM, Robertson LW, Srinivasan C, Ludewig G. Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1. Toxicology and Applied Pharmacology. 187: 168-77. PMID 12662900 DOI: 10.1016/S0041-008X(02)00069-8  0.13
2023 Roh T, Knappett PSK, Han D, Ludewig G, Kelly KM, Wang K, Weyer PJ. Characterization of Arsenic and Atrazine Contaminations in Drinking Water in Iowa: A Public Health Concern. International Journal of Environmental Research and Public Health. 20. PMID 37048011 DOI: 10.3390/ijerph20075397  0.113
2018 Liu B, Sun Y, Xu G, Snetselaar LG, Ludewig G, Wallace RB, Bao W. Association between Body Iron Status and Leukocyte Telomere Length, a Biomarker of Biological Aging, in a Nationally Representative Sample of US Adults. Journal of the Academy of Nutrition and Dietetics. PMID 30563782 DOI: 10.1016/J.Jand.2018.09.007  0.112
2023 Nault R, Cave MC, Ludewig G, Moseley HNB, Pennell KG, Zacharewski T. A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data. Environmental Health Perspectives. 131: 65001. PMID 37352010 DOI: 10.1289/EHP11484  0.063
2010 Ludewig G, Robertson LW. A primary objective of the 2008 workshop was to bring these scientists together in one location to facilitate interactions and the exchange of information. Preface. Environment International. 36: 813. PMID 20688397 DOI: 10.1016/J.Envint.2010.07.004  0.01
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