Tom Maniatis, Phd - Publications

Biochemistry and Molecular Biophysics Harvard University, Cambridge, MA, United States 
 Columbia University, New York, NY 
Regulation of RNA Transcription and Splicing, The Role of Neuroinflammation in ALS, Neurobiology of Disease, Synapses and Circuits, Stem Cell Biology, ALS Disease Mechanisms, Genetic Basis of Neurological Diseases

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Year Citation  Score
2020 Gerbino V, Kaunga E, Ye J, Canzio D, O'Keeffe S, Rudnick ND, Guarnieri P, Lutz CM, Maniatis T. The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice. Neuron. PMID 32220666 DOI: 10.1016/j.neuron.2020.03.005  0.68
2019 Ye J, Cheung J, Gerbino V, Ahlsén G, Zimanyi C, Hirsh D, Maniatis T. Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31748271 DOI: 10.1073/pnas.1915732116  0.68
2019 Canzio D, Maniatis T. The generation of a protocadherin cell-surface recognition code for neural circuit assembly. Current Opinion in Neurobiology. 59: 213-220. PMID 31710891 DOI: 10.1016/j.conb.2019.10.001  0.64
2019 Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T. Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice. Cell. PMID 30955885 DOI: 10.1016/j.cell.2019.03.008  0.64
2019 Gelfman S, Dugger SA, Araujo Martins Moreno C, Ren Z, Wolock CJ, Shneider N, Phatnani H, Cirulli ET, Lasseigne BN, Harris T, Maniatis T, Rouleau G, Brown RH, Gitler AD, Myers RM, et al. A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS. Genome Research. PMID 30940688 DOI: 10.1101/gr.243592.118  0.84
2018 Mountoufaris G, Canzio D, Nwakeze CL, Chen WV, Maniatis T. Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly. Annual Review of Cell and Developmental Biology. 34: 471-493. PMID 30296392 DOI: 10.1146/annurev-cellbio-100616-060701  0.64
2018 Yuan Y, Xie S, Darnell JC, Darnell AJ, Saito Y, Phatnani H, Murphy EA, Zhang C, Maniatis T, Darnell RB. Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons. Genome Biology. 19: 117. PMID 30111345 DOI: 10.1186/s13059-018-1493-2  0.4
2018 Duffy EE, Canzio D, Maniatis T, Simon MD. Solid phase chemistry to covalently and reversibly capture thiolated RNA. Nucleic Acids Research. PMID 29986098 DOI: 10.1093/nar/gky556  0.64
2017 Rudnick ND, Griffey CJ, Guarnieri P, Gerbino V, Wang X, Piersaint JA, Tapia JC, Rich MM, Maniatis T. Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS. Proceedings of the National Academy of Sciences of the United States of America. PMID 28904095 DOI: 10.1073/pnas.1704294114  0.52
2017 Mountoufaris G, Chen WV, Hirabayashi Y, O'Keeffe S, Chevee M, Nwakeze CL, Polleux F, Maniatis T. Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. Science (New York, N.Y.). 356: 411-414. PMID 28450637 DOI: 10.1126/science.aai8801  0.64
2017 Chen WV, Nwakeze CL, Denny CA, O'Keeffe S, Rieger MA, Mountoufaris G, Kirner A, Dougherty JD, Hen R, Wu Q, Maniatis T. Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science (New York, N.Y.). 356: 406-411. PMID 28450636 DOI: 10.1126/science.aal3231  1
2016 Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. γ-Protocadherin structural diversity and functional implications. Elife. 5. PMID 27782885 DOI: 10.7554/eLife.20930  0.36
2016 He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, et al. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162329 DOI: 10.1073/pnas.1605707113  0.44
2016 Goodman KM, Rubinstein R, Thu CA, Bahna F, Mannepalli S, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins. Neuron. PMID 27161523 DOI: 10.1016/j.neuron.2016.04.004  0.44
2015 Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B. Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions. Cell. 163: 629-42. PMID 26478182 DOI: 10.1016/j.cell.2015.09.026  0.44
2015 Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, ... ... Maniatis T, et al. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 162: 900-10. PMID 26276636 DOI: 10.1016/j.cell.2015.07.038  1
2015 Ye J, Beetz N, O'Keeffe S, Tapia JC, Macpherson L, Chen WV, Bassel-Duby R, Olson EN, Maniatis T. hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Proceedings of the National Academy of Sciences of the United States of America. 112: E3020-9. PMID 26039991 DOI: 10.1073/pnas.1508461112  1
2015 Phatnani H, Maniatis T. Astrocytes in Neurodegenerative Disease. Cold Spring Harbor Perspectives in Biology. 7. PMID 25877220 DOI: 10.1101/cshperspect.a020628  1
2015 Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, ... ... Maniatis T, et al. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science (New York, N.Y.). 347: 1436-41. PMID 25700176 DOI: 10.1126/science.aaa3650  0.44
2015 Maniatis T. Resident duty-hour reform: moving beyond "change for change's sake". Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 187: 309-10. PMID 25667251 DOI: 10.1503/cmaj.150010  1
2014 Sun NZ, Maniatis T. Scheduling in the context of resident duty hour reform. Bmc Medical Education. 14: S18. PMID 25561221 DOI: 10.1186/1472-6920-14-S1-S18  1
2014 Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11929-47. PMID 25186741 DOI: 10.1523/JNEUROSCI.1860-14.2014  1
2014 Thu CA, Chen WV, Rubinstein R, Chevee M, Wolcott HN, Felsovalyi KO, Tapia JC, Shapiro L, Honig B, Maniatis T. Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins. Cell. 158: 1045-59. PMID 25171406 DOI: 10.1016/j.cell.2014.07.012  1
2014 Abdallah T, Abdallah M, Elsayegh D, Chalhoub M, Khoueiry G, Glatman A, Maniatis T. Isolated dysphagia unmasking bulbar neurosarcoidosis and pulmonary sarcoidosis. Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology. 15: 85-7. PMID 25097053 DOI: 10.1016/j.ajg.2014.03.001  0.56
2014 Harris K, Hatem E, Maroun R, Seminara D, Maniatis T. A renal angiomyolipoma with extension to the renal vein and asymptomatic fat pulmonary embolus. Therapeutic Advances in Respiratory Disease. 8: 133-135. PMID 25034022 DOI: 10.1177/1753465814538690  0.56
2014 Nishimura AL, Shum C, Scotter EL, Abdelgany A, Sardone V, Wright J, Lee YB, Chen HJ, Bilican B, Carrasco M, Maniatis T, Chandran S, Rogelj B, Gallo JM, Shaw CE. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells. Plos One. 9: e91269. PMID 24651281 DOI: 10.1371/journal.pone.0091269  0.44
2014 Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, ... ... Maniatis T, et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 81: 536-43. PMID 24507191 DOI: 10.1016/j.neuron.2013.12.018  1
2014 Duffy MC, Azevedo R, Sun NZ, Griscom SE, Stead V, Crelinsten L, Wiseman J, Maniatis T, Lachapelle K. Team regulation in a simulated medical emergency: An in-depth analysis of cognitive, metacognitive, and affective processes Instructional Science. DOI: 10.1007/s11251-014-9333-6  1
2013 Chen WV, Maniatis T. Clustered protocadherins. Development (Cambridge, England). 140: 3297-302. PMID 23900538 DOI: 10.1242/dev.090621  1
2013 Bilican B, Serio A, Shaw CE, Maniatis T, Chandran S. Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time. Cell Cycle (Georgetown, Tex.). 12: 2339-40. PMID 23856579 DOI: 10.4161/cc.25705  1
2013 Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Reports. 4: 385-401. PMID 23850290 DOI: 10.1016/j.celrep.2013.06.018  1
2013 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, ... ... Maniatis T, et al. Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Science Translational Medicine. 5: 188le2. PMID 23740897 DOI: 10.1126/scitranslmed.3005065  1
2013 Habib N, Hassan S, Abdou R, Torbey E, Alkaied H, Maniatis T, Azab B, Chalhoub M, Harris K. Gastroduodenal artery aneurysm, diagnosis, clinical presentation and management: a concise review. Annals of Surgical Innovation and Research. 7: 4. PMID 23587203 DOI: 10.1186/1750-1164-7-4  0.56
2013 Gebhardt JC, Suter DM, Roy R, Zhao ZW, Chapman AR, Basu S, Maniatis T, Xie XS. Single-molecule imaging of transcription factor binding to DNA in live mammalian cells. Nature Methods. 10: 421-6. PMID 23524394 DOI: 10.1038/nmeth.2411  1
2013 Larabi A, Devos JM, Ng SL, Nanao MH, Round A, Maniatis T, Panne D. Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Reports. 3: 734-46. PMID 23453971 DOI: 10.1016/j.celrep.2013.01.034  1
2013 Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, et al. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proceedings of the National Academy of Sciences of the United States of America. 110: 4697-702. PMID 23401527 DOI: 10.1073/pnas.1300398110  1
2013 Phatnani HP, Guarnieri P, Friedman BA, Carrasco MA, Muratet M, O'Keeffe S, Nwakeze C, Pauli-Behn F, Newberry KM, Meadows SK, Tapia JC, Myers RM, Maniatis T. Intricate interplay between astrocytes and motor neurons in ALS. Proceedings of the National Academy of Sciences of the United States of America. 110: E756-65. PMID 23388633 DOI: 10.1073/pnas.1222361110  1
2013 Amoroso MW, Croft GF, Williams DJ, O'Keeffe S, Carrasco MA, Davis AR, Roybon L, Oakley DH, Maniatis T, Henderson CE, Wichterle H. Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 574-86. PMID 23303937 DOI: 10.1523/JNEUROSCI.0906-12.2013  1
2013 Harris K, Maniatis G, Siddiqui F, Maniatis T. Phrenic nerve injury and diaphragmatic paralysis following pacemaker pulse generator replacement. Heart & Lung : the Journal of Critical Care. 42: 65-6. PMID 23083538 DOI: 10.1016/j.hrtlng.2012.09.002  0.56
2012 Guo Y, Monahan K, Wu H, Gertz J, Varley KE, Li W, Myers RM, Maniatis T, Wu Q. CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice. Proceedings of the National Academy of Sciences of the United States of America. 109: 21081-6. PMID 23204437 DOI: 10.1073/pnas.1219280110  1
2012 Maniatis T. On the road from classical to modern molecular biology. Nature Medicine. 18: 1499-502. PMID 23042362 DOI: 10.1038/nm.2931  1
2012 Zhang QC, Petrey D, Deng L, Qiang L, Shi Y, Thu CA, Bisikirska B, Lefebvre C, Accili D, Hunter T, Maniatis T, Califano A, Honig B. Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature. 490: 556-60. PMID 23023127 DOI: 10.1038/nature11503  1
2012 Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, ... ... Maniatis T, et al. FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Reports. 2: 799-806. PMID 23022481 DOI: 10.1016/j.celrep.2012.08.025  1
2012 Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. Plos One. 7: e43099. PMID 22952635 DOI: 10.1371/journal.pone.0043099  1
2012 Li Y, Xiao H, Chiou TT, Jin H, Bonhomme B, Miralles CP, Pinal N, Ali R, Chen WV, Maniatis T, De Blas AL. Molecular and functional interaction between protocadherin-γC5 and GABAA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11780-97. PMID 22915120 DOI: 10.1523/JNEUROSCI.0969-12.2012  1
2012 Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E, Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR, Maniatis T. Functional significance of isoform diversification in the protocadherin gamma gene cluster. Neuron. 75: 402-9. PMID 22884324 DOI: 10.1016/j.neuron.2012.06.039  1
2012 Lefebvre JL, Kostadinov D, Chen WV, Maniatis T, Sanes JR. Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature. 488: 517-21. PMID 22842903 DOI: 10.1038/nature11305  1
2012 Harris K, Khachaturova I, Azab B, Maniatis T, Murukutla S, Chalhoub M, Hatoum H, Kilkenny T, Elsayegh D, Maroun R, Alkaied H. Small cell lung cancer doubling time and its effect on clinical presentation: a concise review. Clinical Medicine Insights. Oncology. 6: 199-203. PMID 22619563 DOI: 10.4137/CMO.S9633  0.56
2012 Monahan K, Rudnick ND, Kehayova PD, Pauli F, Newberry KM, Myers RM, Maniatis T. Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-α gene expression. Proceedings of the National Academy of Sciences of the United States of America. 109: 9125-30. PMID 22550178 DOI: 10.1073/pnas.1205074109  1
2012 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, ... ... Maniatis T, et al. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 109: 5803-8. PMID 22451909 DOI: 10.1073/pnas.1202922109  1
2012 Habib N, Maniatis T, Ahmed S, Kilkenny T, Alkaied H, Elsayegh D, Chalhoub M, Harris K. Cement pulmonary embolism after percutaneous vertebroplasty and kyphoplasty: An overview Heart and Lung: Journal of Acute and Critical Care. 41: 509-511. PMID 22425258 DOI: 10.1016/j.hrtlng.2012.02.008  0.56
2012 Zhao M, Zhang J, Phatnani H, Scheu S, Maniatis T. Stochastic expression of the interferon-β gene Plos Biology. 10. PMID 22291574 DOI: 10.1371/journal.pbio.1001249  1
2011 Ng SL, Friedman BA, Schmid S, Gertz J, Myers RM, Tenoever BR, Maniatis T. IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses. Proceedings of the National Academy of Sciences of the United States of America. 108: 21170-5. PMID 22171011 DOI: 10.1073/pnas.1119137109  1
2011 Kehayova P, Monahan K, Chen W, Maniatis T. Regulatory elements required for the activation and repression of the protocadherin-á gene cluster Proceedings of the National Academy of Sciences of the United States of America. 108: 17195-17200. PMID 21949399 DOI: 10.1073/pnas.1114357108  1
2011 Ye J, Maniatis T. A prion-like trigger of antiviral signaling. Cell. 146: 348-50. PMID 21816270 DOI: 10.1016/j.cell.2011.07.018  0.68
2011 Friedman BA, Maniatis T. ExpressionPlot: A web-based framework for analysis of RNA-Seq and microarray gene expression data Genome Biology. 12. PMID 21797991 DOI: 10.1186/gb-2011-12-7-r69  1
2011 Ye J, Maniatis T. Negative regulation of interferon-β gene expression during acute and persistent virus infections. Plos One. 6: e20681. PMID 21677781 DOI: 10.1371/journal.pone.0020681  0.68
2011 Ye J, Chen S, Maniatis T. Cardiac glycosides are potent inhibitors of interferon-β gene expression Nature Chemical Biology. 7: 25-33. PMID 21076398 DOI: 10.1038/nchembio.476  1
2011 Ye J, Maniatis T. Negative regulation of interferon-β gene expression during acute and persistent virus infections Plos One. 6. DOI: 10.1371/journal.pone.0020681  1
2011 Ye J, Maniatis T. A prion-like trigger of antiviral signaling Cell. 146: 348-350. DOI: 10.1016/j.cell.2011.07.018  1
2010 Gaddam S, Koirala A, Nimmagadda KC, Kohli PS, Wetz RV, Maniatis T. Smoke trails of a dying gut: portal and mesenteric vein gas. Bmj Case Reports. 2010. PMID 22791777  0.56
2010 Gaddam S, Koirala A, Giangola G, Lafferty J, Maniatis T. Haemoptysis from an innominate artery aneurysm. Bmj Case Reports. 2010. PMID 22778197 DOI: 10.1136/bcr.10.2009.2384  0.56
2010 Buchanan SM, Schalm SS, Maniatis T. Proteolytic processing of protocadherin proteins requires endocytosis Proceedings of the National Academy of Sciences of the United States of America. 107: 17774-17779. PMID 20876099 DOI: 10.1073/pnas.1013105107  1
2010 Castellanos MR, Szerszen A, Saifan C, Zigelboym I, Khoueiry G, Abi Rafeh N, Wetz RV, Kleiner M, Aoun N, Weiserbs KF, Maniatis T, Rothman J. Fasting hyperglycemia upon hospital admission is associated with higher pneumonia complication rates among the elderly. International Archives of Medicine. 3: 16. PMID 20678212 DOI: 10.1186/1755-7682-3-16  0.56
2010 Schalm SS, Ballif BA, Buchanan SM, Phillips GR, Maniatis T. Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret Proceedings of the National Academy of Sciences of the United States of America. 107: 13894-13899. PMID 20616001 DOI: 10.1073/pnas.1007182107  1
2010 Huang HR, Chen ZJ, Kunes S, Chang GD, Maniatis T. Endocytic pathway is required for Drosophila Toll innate immune signaling. Proceedings of the National Academy of Sciences of the United States of America. 107: 8322-7. PMID 20404143 DOI: 10.1073/pnas.1004031107  1
2009 Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 20960-5. PMID 19933335 DOI: 10.1073/pnas.0911405106  1
2008 Falvo JV, Lin CH, Tsytsykova AV, Hwang PK, Thanos D, Goldfeld AE, Maniatis T. A dimer-specific function of the transcription factor NFATp Proceedings of the National Academy of Sciences of the United States of America. 105: 19637-19642. PMID 19060202 DOI: 10.1073/pnas.0810648105  1
2008 Zhang B, Maniatis T, Song Y, Zhang W, Zhang X, Li N, Chen J, Wong AW, Roberts A. Evaluation of magnolia bark extract in chromosomal aberration assays. Mutation Research. 654: 133-7. PMID 18639484 DOI: 10.1016/j.mrgentox.2008.05.009  0.56
2008 Makeyev EV, Maniatis T. Multilevel regulation of gene expression by microRNAs Science. 319: 1789-1790. PMID 18369137 DOI: 10.1126/science.1152326  1
2007 Makeyev EV, Zhang J, Carrasco MA, Maniatis T. The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Molecular Cell. 27: 435-48. PMID 17679093 DOI: 10.1016/j.molcel.2007.07.015  1
2007 Panne D, Maniatis T, Harrison SC. An atomic model of the interferon-beta enhanceosome. Cell. 129: 1111-23. PMID 17574024 DOI: 10.1016/j.cell.2007.05.019  1
2007 Panne D, McWhirter SM, Maniatis T, Harrison SC. Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. The Journal of Biological Chemistry. 282: 22816-22. PMID 17526488 DOI: 10.1074/jbc.M703019200  1
2007 Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nature Neuroscience. 10: 608-14. PMID 17435754 DOI: 10.1038/nn1885  1
2007 Tenoever BR, Ng SL, Chua MA, McWhirter SM, García-Sastre A, Maniatis T. Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science (New York, N.Y.). 315: 1274-8. PMID 17332413 DOI: 10.1126/science.1136567  1
2006 Ribich S, Tasic B, Maniatis T. Identification of long-range regulatory elements in the protocadherin-alpha gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 103: 19719-24. PMID 17172445 DOI: 10.1073/pnas.0609445104  1
2006 Scheinfeld MH, Maniatis T, Gurell D. COPD? American Journal of Medicine. 119: 839-842. PMID 17000214 DOI: 10.1016/j.amjmed.2006.08.012  0.56
2006 Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF. Systems-level analyses identify extensive coupling among gene expression machines. Molecular Systems Biology. 2: 2006.0003. PMID 16738550 DOI: 10.1038/msb4100045  1
2006 Tenoever BR, Maniatis T. Parallel pathways of virus recognition. Immunity. 24: 510-2. PMID 16713969 DOI: 10.1016/j.immuni.2006.05.006  1
2005 McWhirter SM, Tenoever BR, Maniatis T. Connecting mitochondria and innate immunity. Cell. 122: 645-7. PMID 16143094 DOI: 10.1016/j.cell.2005.08.026  1
2005 Zhou R, Silverman N, Hong M, Liao DS, Chung Y, Chen ZJ, Maniatis T. The role of ubiquitination in Drosophila innate immunity Journal of Biological Chemistry. 280: 34048-34055. PMID 16081424 DOI: 10.1074/jbc.M506655200  1
2005 Takahara T, Tasic B, Maniatis T, Akanuma H, Yanagisawa S. Delay in synthesis of the 3' splice site promotes trans-splicing of the preceding 5' splice site. Molecular Cell. 18: 245-51. PMID 15837427 DOI: 10.1016/j.molcel.2005.03.018  1
2005 Ibrahim EC, Schaal TD, Hertel KJ, Reed R, Maniatis T. Serine/arginine-rich protein-dependent suppression of exon skipping by exonic splicing enhancers. Proceedings of the National Academy of Sciences of the United States of America. 102: 5002-7. PMID 15753297 DOI: 10.1073/pnas.0500543102  1
2004 Panne D, Maniatis T, Harrison SC. Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-β enhancer Embo Journal. 23: 4384-4393. PMID 15510218 DOI: 10.1038/sj.emboj.7600453  1
2004 McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts Proceedings of the National Academy of Sciences of the United States of America. 101: 233-238. PMID 14679297 DOI: 10.1073/pnas.2237236100  1
2003 Silverman N, Zhou R, Erlich RL, Hunter M, Bernstein E, Schneider D, Maniatis T. Immune activation of NF-kappaB and JNK requires Drosophila TAK1. The Journal of Biological Chemistry. 278: 48928-48934. PMID 14519762 DOI: 10.1074/jbc.M304802200  1
2003 Stoven S, Silverman N, Junell A, Hedengren-Olcott M, Erturk D, Engstrom Y, Maniatis T, Hultmark D. Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proceedings of the National Academy of Sciences of the United States of America. 100: 5991-6. PMID 12732719 DOI: 10.1073/pnas.1035902100  1
2003 Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. IKKE and TBKI are essential components of the IRF3 signalling pathway Nature Immunology. 4: 491-496. PMID 12692549 DOI: 10.1038/ni921  1
2002 Araujo-Preza CE, Melhado ME, Gutierrez FJ, Maniatis T, Castellano MA. Use of capnometry to verify feeding tube placement. Critical Care Medicine. 30: 2255-9. PMID 12394953 DOI: 10.1097/01.CCM.0000029195.23950.0D  0.56
2002 Tasic B, Nabholz CE, Baldwin KK, Kim Y, Rueckert EH, Ribich SA, Cramer P, Wu Q, Axel R, Maniatis T. Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing. Molecular Cell. 10: 21-33. PMID 12150904 DOI: 10.1016/S1097-2765(02)00578-6  1
2002 Maniatis T, Tasic B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature. 418: 236-43. PMID 12110900 DOI: 10.1038/418236a  1
2002 Maniatis T, Reed R. An extensive network of coupling among gene expression machines. Nature. 416: 499-506. PMID 11932736 DOI: 10.1038/416499a  1
2001 Lin CH, Hare BJ, Wagner G, Harrison SC, Maniatis T, Fraenkel E. A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies. Molecular Cell. 8: 581-90. PMID 11583620 DOI: 10.1016/S1097-2765(01)00333-1  1
2001 Silverman N, Maniatis T. NF-κB signaling pathways in mammalian and insect innate immunity Genes and Development. 15: 2321-2342. PMID 11562344 DOI: 10.1101/gad.909001  1
2001 Graveley BR, Hertel KJ, Maniatis T. The role of U2AF35 and U2AF65 in enhancer-dependent splicing. Rna (New York, N.Y.). 7: 806-18. PMID 11421359 DOI: 10.1017/S1355838201010317  1
2001 Peters RT, Maniatis T. A new family of IKK-related kinases may function as I kappa B kinase kinases. Biochimica Et Biophysica Acta. 1471: M57-62. PMID 11342184 DOI: 10.1016/S0304-419X(00)00024-X  1
2001 Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M, Noonan JP, Zhang MQ, Myers RM, Maniatis T. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Research. 11: 389-404. PMID 11230163 DOI: 10.1101/gr.167301  1
2000 Agalioti T, Lomvardas S, Parekh B, Yie J, Maniatis T, Thanos D. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell. 103: 667-78. PMID 11106736 DOI: 10.1016/S0092-8674(00)00169-0  1
2000 Silverman N, Zhou R, Stöven S, Pandey N, Hultmark D, Maniatis T. A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes & Development. 14: 2461-71. PMID 11018014 DOI: 10.1101/gad.817800  1
2000 Peters RT, Liao SM, Maniatis T. IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Molecular Cell. 5: 513-22. PMID 10882136  1
2000 Falvo JV, Parekh BS, Lin CH, Fraenkel E, Maniatis T. Assembly of a functional beta interferon enhanceosome is dependent on ATF-2-c-jun heterodimer orientation. Molecular and Cellular Biology. 20: 4814-25. PMID 10848607 DOI: 10.1128/MCB.20.13.4814-4825.2000  1
2000 Wu Q, Maniatis T. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. Proceedings of the National Academy of Sciences of the United States of America. 97: 3124-9. PMID 10716726 DOI: 10.1073/pnas.060027397  1
2000 Falvo JV, Uglialoro AM, Brinkman BM, Merika M, Parekh BS, Tsai EY, King HC, Morielli AD, Peralta EG, Maniatis T, Thanos D, Goldfeld AE. Stimulus-specific assembly of enhancer complexes on the tumor necrosis factor alpha gene promoter. Molecular and Cellular Biology. 20: 2239-47. PMID 10688670 DOI: 10.1128/MCB.20.6.2239-2247.2000  1
2000 Gaur RK, Beigelman L, Haeberli P, Maniatis T. Role of adenine functional groups in the recognition of the 3'-splice-site AG during the second step of pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 97: 115-20. PMID 10618380 DOI: 10.1073/pnas.97.1.115  1
2000 Parekh BS, Maniatis T. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-β promoter Chemtracts. 13: 661-668.  1
1999 Wu Q, Maniatis T. A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 97: 779-90. PMID 10380929 DOI: 10.1016/S0092-8674(00)80789-8  1
1999 Hertel KJ, Maniatis T. Serine-arginine (SR)-rich splicing factors have an exon-independent function in pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 96: 2651-5. PMID 10077565 DOI: 10.1073/pnas.96.6.2651  1
1999 Maniatis T. A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. Genes & Development. 13: 505-10. PMID 10072378  1
1999 Parekh BS, Maniatis T. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter. Molecular Cell. 3: 125-9. PMID 10024886 DOI: 10.1016/S1097-2765(00)80181-1  1
1999 Schaal TD, Maniatis T. Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Molecular and Cellular Biology. 19: 1705-19. PMID 10022858  1
1999 Graveley BR, Hertel KJ, Maniatis T. SR proteins are 'locators' of the RNA splicing machinery. Current Biology : Cb. 9: R6-7. PMID 9889128  1
1999 Ren B, Chee KJ, Kim TH, Maniatis T. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes & Development. 13: 125-37. PMID 9887105  1
1999 Schaal TD, Maniatis T. Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Molecular and Cellular Biology. 19: 261-73. PMID 9858550  1
1998 Maniatis T, Falvo JV, Kim TH, Kim TK, Lin CH, Parekh BS, Wathelet MG. Structure and function of the interferon-beta enhanceosome. Cold Spring Harbor Symposia On Quantitative Biology. 63: 609-20. PMID 10384326  1
1998 Graveley BR, Hertel KJ, Maniatis T. A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers. The Embo Journal. 17: 6747-56. PMID 9822617 DOI: 10.1093/emboj/17.22.6747  1
1998 Kim TK, Kim TH, Maniatis T. Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro. Proceedings of the National Academy of Sciences of the United States of America. 95: 12191-6. PMID 9770462 DOI: 10.1073/pnas.95.21.12191  1
1998 Lee FS, Peters RT, Dang LC, Maniatis T. MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. Proceedings of the National Academy of Sciences of the United States of America. 95: 9319-24. PMID 9689078 DOI: 10.1073/pnas.95.16.9319  1
1998 Graveley BR, Maniatis T. Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing. Molecular Cell. 1: 765-71. PMID 9660960  1
1998 Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Molecular Cell. 1: 507-18. PMID 9660935  0.6
1998 Hertel KJ, Maniatis T. The function of multisite splicing enhancers. Molecular Cell. 1: 449-55. PMID 9660929 DOI: 10.1016/S1097-2765(00)80045-3  1
1998 Ren B, Maniatis T. Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism. The Embo Journal. 17: 1076-86. PMID 9463385 DOI: 10.1093/emboj/17.4.1076  1
1998 Sears C, Olesen J, Rubin D, Finley D, Maniatis T. NF-kappa B p105 processing via the ubiquitin-proteasome pathway. The Journal of Biological Chemistry. 273: 1409-19. PMID 9430676 DOI: 10.1074/jbc.273.3.1409  1
1998 Castellano MA, Maniatis T. Treatment of LRTIs: Two antimicrobials compared Infections in Medicine. 15: 256+259-263.  0.56
1998 Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM, Maniatis T. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo Molecular Cell. 1: 507-518.  1
1997 Kim TK, Maniatis T. The mechanism of transcriptional synergy of an in vitro assembled interferon-beta enhanceosome. Molecular Cell. 1: 119-29. PMID 9659909  1
1997 Maniatis T. Catalysis by a multiprotein IkappaB kinase complex. Science (New York, N.Y.). 278: 818-9. PMID 9381193 DOI: 10.1126/science.278.5339.818  1
1997 Hertel KJ, Lynch KW, Maniatis T. Common themes in the function of transcription and splicing enhancers. Current Opinion in Cell Biology. 9: 350-7. PMID 9159075 DOI: 10.1016/S0955-0674(97)80007-5  1
1997 Yang JH, Sklar P, Axel R, Maniatis T. Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. Proceedings of the National Academy of Sciences of the United States of America. 94: 4354-9. PMID 9113993 DOI: 10.1073/pnas.94.9.4354  1
1997 Powell DM, Amaral MC, Wu JY, Maniatis T, Greene WC. HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 94: 973-8. PMID 9023367 DOI: 10.1073/pnas.94.3.973  1
1997 Lee FS, Hagler J, Chen ZJ, Maniatis T. Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell. 88: 213-22. PMID 9008162 DOI: 10.1016/S0092-8674(00)81842-5  1
1997 Ren B, Maniatis T. Regulation of the drosophila adh promoter switch by an initiator targeted repression mechanism Faseb Journal. 11: A1200.  1
1996 Thanos D, Maniatis T. In vitro assembly of enhancer complexes. Methods in Enzymology. 274: 162-73. PMID 8902803 DOI: 10.1016/S0076-6879(96)74015-6  1
1996 Hertel KJ, Lynch KW, Hsiao EC, Liu EH, Maniatis T. Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements. Rna (New York, N.Y.). 2: 969-81. PMID 8849774  1
1996 Kim TK, Maniatis T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science (New York, N.Y.). 273: 1717-9. PMID 8781235  1
1996 Lynch KW, Maniatis T. Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes & Development. 10: 2089-101. PMID 8769651  1
1996 Zuo P, Maniatis T. The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes & Development. 10: 1356-68. PMID 8647433  1
1996 Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell. 84: 853-62. PMID 8601309 DOI: 10.1016/S0092-8674(00)81064-8  1
1995 Falvo JV, Thanos D, Maniatis T. Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y). Cell. 83: 1101-11. PMID 8548798 DOI: 10.1016/0092-8674(95)90137-X  1
1995 Thanos D, Maniatis T. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell. 83: 1091-100. PMID 8548797 DOI: 10.1016/0092-8674(95)90136-1  1
1995 Hedley ML, Amrein H, Maniatis T. An amino acid sequence motif sufficient for subnuclear localization of an arginine/serine-rich splicing factor. Proceedings of the National Academy of Sciences of the United States of America. 92: 11524-8. PMID 8524796 DOI: 10.1073/pnas.92.25.11524  1
1995 Yang JH, Sklar P, Axel R, Maniatis T. Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine. Nature. 374: 77-81. PMID 7870177 DOI: 10.1038/374077a0  1
1995 Lynch KW, Maniatis T. Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes & Development. 9: 284-93. PMID 7867927  1
1995 Thanos D, Maniatis T. NF-kappa B: a lesson in family values. Cell. 80: 529-32. PMID 7867060 DOI: 10.1016/0092-8674(95)90506-5  1
1995 Thanos D, Maniatis T. Identification of the rel family members required for virus induction of the human beta interferon gene Molecular and Cellular Biology. 15: 152-164. PMID 7799921  1
1995 Lazar G, Schaal T, Maniatis T, Goodman HM. Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF. Proceedings of the National Academy of Sciences of the United States of America. 92: 7672-6. PMID 7644475 DOI: 10.1073/pnas.92.17.7672  1
1995 Abdulkadir SA, Krishna S, Thanos D, Maniatis T, Strominger JL, Ono SJ. Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression. The Journal of Experimental Medicine. 182: 487-500. PMID 7629508 DOI: 10.1084/jem.182.2.487  1
1995 Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D, Maniatis T. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes & Development. 9: 1586-97. PMID 7628694  1
1995 Bruzik JP, Maniatis T. Enhancer-dependent interaction between 5' and 3' splice sites in trans. Proceedings of the National Academy of Sciences of the United States of America. 92: 7056-9. PMID 7624368 DOI: 10.1073/pnas.92.15.7056  1
1995 Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 899-909. PMID 7542214  1
1995 Read MA, Neish AS, Luscinskas FW, Palombella VJ, Maniatis T, Collins T. The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity. 2: 493-506. PMID 7538441 DOI: 10.1016/1074-7613(95)90030-6  1
1995 Neish AS, Read MA, Thanos D, Pine R, Maniatis T, Collins T. Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1. Molecular and Cellular Biology. 15: 2558-69. PMID 7537851 DOI: 10.1128/MCB.15.5.2558  1
1995 Scherer DC, Brockman JA, Chen Z, Maniatis T, Ballard DW. Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proceedings of the National Academy of Sciences of the United States of America. 92: 11259-63. PMID 7479976  1
1994 Tjian R, Maniatis T. Transcriptional activation: A complex puzzle with few easy pieces Cell. 77: 5-8. PMID 8156597 DOI: 10.1016/0092-8674(94)90227-5  1
1994 Amrein H, Hedley ML, Maniatis T. The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell. 76: 735-46. PMID 8124712 DOI: 10.1016/0092-8674(94)90512-6  1
1994 Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB Cell. 78: 773-785. PMID 8087845 DOI: 10.1016/S0092-8674(94)90482-0  1
1994 Lehming N, Thanos D, Brickman JM, Ma J, Maniatis T, Ptashne M. An HMG-like protein that can switch a transcriptional activator to a repressor. Nature. 371: 175-9. PMID 8072548 DOI: 10.1038/371175a0  1
1994 Du W, Maniatis T. The high mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms Proceedings of the National Academy of Sciences of the United States of America. 91: 11318-11322. PMID 7972056 DOI: 10.1073/pnas.91.24.11318  1
1994 Tian M, Maniatis T. A splicing enhancer exhibits both constitutive and regulated activities Genes and Development. 8: 1703-1712. PMID 7958850  1
1994 Whitley MZ, Thanos D, Read MA, Maniatis T, Collins T. A striking similarity in the organization of the E-selectin and beta interferon gene promoters Molecular and Cellular Biology. 14: 6464-6475. PMID 7523851  1
1993 Du W, Thanos D, Maniatis T. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements Cell. 74: 887-898. PMID 8374955 DOI: 10.1016/0092-8674(93)90468-6  1
1993 Tian M, Maniatis T. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA Cell. 74: 105-114. PMID 8334698 DOI: 10.1016/0092-8674(93)90298-5  1
1993 Wu JY, Maniatis T. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell. 75: 1061-70. PMID 8261509 DOI: 10.1016/0092-8674(93)90316-I  1
1993 Abel T, Michelson AM, Maniatis T. A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development (Cambridge, England). 119: 623-33. PMID 8187633  1
1993 Thanos D, Du W, Maniatis T. The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex Cold Spring Harbor Symposia On Quantitative Biology. 58: 73-81. PMID 7956090  1
1993 Winick J, Abel T, Leonard MW, Michelson AM, Chardon-Loriaux I, Holmgren RA, Maniatis T, Engel JD. A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster. Development (Cambridge, England). 119: 1055-65. PMID 7916677  1
1992 Maniatis T, Weintraub H. Gene expression and differentiation Current Opinion in Genetics and Development. 2: 197-198. PMID 1638112 DOI: 10.1016/S0959-437X(05)80273-4  1
1992 Palombella VJ, Maniatis T. Inducible processing of interferon regulatory factor-2 Molecular and Cellular Biology. 12: 3325-3336. PMID 1630448  1
1992 Keller AD, Maniatis T. Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding Molecular and Cellular Biology. 12: 1940-1949. PMID 1569931  1
1992 Tian M, Maniatis T. Positive control of pre-mRNA splicing in vitro Science. 256: 237-240. PMID 1566072  1
1992 Falb D, Maniatis T. A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man Genes and Development. 6: 454-465. PMID 1547943  1
1992 Du W, Maniatis T. An ATF/CREB binding site protein is required for virus induction of the human interferon β gene Proceedings of the National Academy of Sciences of the United States of America. 89: 2150-2154. PMID 1532252  1
1992 Abel T, Bhatt R, Maniatis T. A Drosophila CREB/ATF transcriptional activator binds to both fat body- and liver-specific regulatory elements. Genes & Development. 6: 466-80. PMID 1532159  1
1992 Fu XD, Maniatis T. The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site Proceedings of the National Academy of Sciences of the United States of America. 89: 1725-1729. PMID 1531875  1
1992 Falb D, Maniatis T. Drosophila transcriptional repressor protein that binds specifically to negative control elements in fat body enhancers Molecular and Cellular Biology. 12: 4093-4103. PMID 1508206  1
1992 Bruzik JP, Maniatis T. Spliced leader RNAs from lower eukaryotes are trans-spliced in mammalian cells Nature. 360: 692-695. PMID 1465136 DOI: 10.1038/360692a0  1
1992 Falb D, Fischer J, Maniatis T. Rearrangement of upstream regulatory elements leads to ectopic expression of the Drosophila mulleri Adh-2 gene Genetics. 132: 1071-1079. PMID 1459428  1
1992 Fu XD, Mayeda A, Maniatis T, Krainer AR. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proceedings of the National Academy of Sciences of the United States of America. 89: 11224-8. PMID 1454802  1
1992 Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979. Biotechnology (Reading, Mass.). 24: 444-52. PMID 1422052  1
1992 Fu XD, Maniatis T. Isolation of a complementary DNA that encodes the mammalian splicing factor SC35 Science. 256: 535-538. PMID 1373910  1
1992 Thanos D, Maniatis T. The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene Cell. 71: 777-789. PMID 1330326 DOI: 10.1016/0092-8674(92)90554-P  1
1991 Fang CM, Maniatis T. Generation of p50 subunit of NF-κB by processing of p105 through an ATP-dependent pathway Nature. 354: 395-398. PMID 1956402 DOI: 10.1038/354395a0  1
1991 Corbin V, Michelson AM, Abmayr SM, Neel V, Alcamo E, Maniatis T, Young MW. A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell. 67: 311-23. PMID 1913825  1
1990 Michelson AM, Abmayr SM, Bate M, Arias AM, Maniatis T. Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos. Genes & Development. 4: 2086-97. PMID 2176634  1
1990 Amrein H, Maniatis T, Nöthiger R. Alternatively spliced transcripts of the sex-determining gene tra-2 of Drosophila encode functional proteins of different size. The Embo Journal. 9: 3619-29. PMID 2120049  1
1989 Abel T, Maniatis T. Gene regulation. Action of leucine zippers. Nature. 341: 24-5. PMID 2671752 DOI: 10.1038/341024a0  1
1988 Zinn K, Keller A, Whittemore LA, Maniatis T. 2-Aminopurine selectively inhibits the induction of beta-interferon, c-fos, and c-myc gene expression. Science (New York, N.Y.). 240: 210-3. PMID 3281258  1
1988 Fischer JA, Giniger E, Maniatis T, Ptashne M. GAL4 activates transcription in Drosophila. Nature. 332: 853-6. PMID 3128741 DOI: 10.1038/332853a0  1
1988 Reed R, Maniatis T. The role of the mammalian branchpoint sequence in pre-mRNA splicing. Genes & Development. 2: 1268-76. PMID 3060403  1
1988 Abmayr SM, Reed R, Maniatis T. Identification of a functional mammalian spliceosome containing unspliced pre-mRNA. Proceedings of the National Academy of Sciences of the United States of America. 85: 7216-20. PMID 2971971  1
1988 Reed R, Griffith J, Maniatis T. Purification and visualization of native spliceosomes. Cell. 53: 949-61. PMID 2968159 DOI: 10.1016/S0092-8674(88)90489-8  1
1987 Myers RM, Maniatis T, Lerman LS. Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods in Enzymology. 155: 501-27. PMID 3431470 DOI: 10.1016/0076-6879(87)55033-9  0.84
1987 Maniatis T, Reed R. The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature. 325: 673-8. PMID 2950324 DOI: 10.1038/325673a0  1
1987 Atweh GF, Wong C, Reed R, Antonarakis SE, Zhu D, Ghosh PK, Maniatis T, Forget BG, Kazazian HH. A new mutation in IVS-1 of the human beta globin gene causing beta thalassemia due to abnormal splicing. Blood. 70: 147-51. PMID 2439149  1
1986 Enoch T, Zinn K, Maniatis T. Activation of the human beta-interferon gene requires an interferon-inducible factor. Molecular and Cellular Biology. 6: 801-10. PMID 3773893  1
1986 Zinn K, Maniatis T. Detection of factors that interact with the human beta-interferon regulatory region in vivo by DNAase I footprinting. Cell. 45: 611-8. PMID 3708689 DOI: 10.1016/0092-8674(86)90293-X  1
1986 Reed R, Maniatis T. A role for exon sequences and splice-site proximity in splice-site selection. Cell. 46: 681-90. PMID 2427200 DOI: 10.1016/0092-8674(86)90343-0  1
1985 Myers RM, Fischer SG, Lerman LS, Maniatis T. Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Research. 13: 3131-45. PMID 4000972 DOI: 10.1093/nar/13.9.3131  0.84
1985 Goodbourn S, Zinn K, Maniatis T. Human beta-interferon gene expression is regulated by an inducible enhancer element. Cell. 41: 509-20. PMID 3986910 DOI: 10.1016/S0092-8674(85)80024-6  1
1985 Myers RM, Lumelsky N, Lerman LS, Maniatis T. Detection of single base substitutions in total genomic DNA. Nature. 313: 495-8. PMID 3969155 DOI: 10.1038/313495a0  0.84
1985 Reed R, Maniatis T. Intron sequences involved in lariat formation during pre-mRNA splicing. Cell. 41: 95-105. PMID 3888410 DOI: 10.1016/0092-8674(85)90064-9  1
1985 Charnay P, Mellon P, Maniatis T. Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells. Molecular and Cellular Biology. 5: 1498-511. PMID 3861935  1
1985 Posakony JW, Fischer JA, Maniatis T. Identification of DNA sequences required for the regulation of Drosophila alcohol dehydrogenase gene expression. Cold Spring Harbor Symposia On Quantitative Biology. 50: 515-20. PMID 3007005  1
1985 Krainer AR, Maniatis T. Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell. 42: 725-36. PMID 2996774 DOI: 10.1016/0092-8674(85)90269-7  1
1985 Myers RM, Lerman LS, Maniatis T. A general method for saturation mutagenesis of cloned DNA fragments. Science (New York, N.Y.). 229: 242-7. PMID 2990046 DOI: 10.1126/science.2990046  0.84
1985 Myers RM, Fischer SG, Maniatis T, Lerman LS. Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Nucleic Acids Research. 13: 3111-29. PMID 2987873 DOI: 10.1093/nar/13.9.3111  0.84
1984 Krainer AR, Maniatis T, Ruskin B, Green MR. Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell. 36: 993-1005. PMID 6323033 DOI: 10.1016/0092-8674(84)90049-7  1
1984 Charnay P, Treisman R, Mellon P, Chao M, Axel R, Maniatis T. Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell. 38: 251-63. PMID 6205764 DOI: 10.1016/0092-8674(84)90547-6  1
1984 Charnay P, Treisman R, Mellon P, Chao M, Axel R, Maniatis T. Human alpha- and beta-globin gene transcription in mouse erythroleukaemia cells. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 307: 261-70. PMID 6151696 DOI: 10.1098/rstb.1984.0126  1
1984 Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K, Green MR. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Research. 12: 7035-56. PMID 6091052 DOI: 10.1093/nar/12.18.7035  1
1984 Ruskin B, Krainer AR, Maniatis T, Green MR. Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell. 38: 317-31. PMID 6088074 DOI: 10.1016/0092-8674(84)90553-1  1
1983 Mellon P, Charnay P, Chao M, Axel R, Maniatis T. Regulated expression of cloned globin genes introduced into mouse erythroleukemia cells. Progress in Clinical and Biological Research. 134: 3-12. PMID 6582520  1
1983 Charnay P, Maniatis T. Transcriptional regulation of globin gene expression in the human erythroid cell line K562. Science (New York, N.Y.). 220: 1281-3. PMID 6574602  1
1983 Chao MV, Mellon P, Charnay P, Maniatis T, Axel R. The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell. 32: 483-93. PMID 6572107 DOI: 10.1016/0092-8674(83)90468-3  1
1983 Zinn K, DiMaio D, Maniatis T. Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Cell. 34: 865-79. PMID 6313211 DOI: 10.1016/0092-8674(83)90544-5  1
1983 Goldberg DA, Posakony JW, Maniatis T. Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the Drosophila germ line. Cell. 34: 59-73. PMID 6309412 DOI: 10.1016/0092-8674(83)90136-8  1
1983 Chao MV, Mellon P, Charnay P, Maniatis T, Axel R. Introduction and expression of beta-globin genes in murine erythroleukemic cells. Gene Amplification and Analysis. 3: 215-31. PMID 6101028  1
1983 Little PF, Treisman R, Bierut L, Seed B, Maniatis T. Plasmid vectors for the rapid isolation and transcriptional analysis of human beta-globin gene alleles. Molecular Biology & Medicine. 1: 473-88. PMID 6094959  0.64
1982 Treisman R, Proudfoot NJ, Shander M, Maniatis T. A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Cell. 29: 903-11. PMID 7151176 DOI: 10.1016/0092-8674(82)90452-4  1
1982 Zinn K, Mellon P, Ptashne M, Maniatis T. Regulated expression of an extrachromosomal human beta-interferon gene in mouse cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 4897-901. PMID 6956899  1
1982 Proudfoot NJ, Gil A, Maniatis T. The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell. 31: 553-63. PMID 6297773 DOI: 10.1016/0092-8674(82)90311-7  1
1980 Proudfoot NJ, Maniatis T. The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Cell. 21: 537-44. PMID 7407925  1
1980 Efstratiadis A, Posakony JW, Maniatis T, Lawn RM, O'Connell C, Spritz RA, DeRiel JK, Forget BG, Weissman SM, Slightom JL, Blechl AE, Smithies O, Baralle FE, Shoulders CC, Proudfoot NJ. The structure and evolution of the human beta-globin gene family. Cell. 21: 653-68. PMID 6985477 DOI: 10.1016/0092-8674(80)90429-8  1
1980 Proudfoot NJ, Shander MH, Manley JL, Gefter ML, Maniatis T. Structure and in vitro transcription of human globin genes. Science (New York, N.Y.). 209: 1329-36. PMID 6158093  1
1979 Hardison RC, Butler ET, Lacy E, Maniatis T, Rosenthal N, Efstratiadis A. The structure and transcription of four linked rabbit beta-like globin genes. Cell. 18: 1285-97. PMID 519769 DOI: 10.1016/0092-8674(79)90239-3  1
1979 Lacy E, Hardison RC, Quon D, Maniatis T. The linkage arrangement of four rabbit beta-like globin genes. Cell. 18: 1273-83. PMID 519768 DOI: 10.1016/0092-8674(79)90238-1  1
1978 Maniatis T, Hardison RC, Lacy E, Lauer J, O'Connell C, Quon D, Sim GK, Efstratiadis A. The isolation of structural genes from libraries of eucaryotic DNA. Cell. 15: 687-701. PMID 719759 DOI: 10.1016/0092-8674(78)90036-3  1
1976 Maniatis T, Ptashne M. A DNA operator-repressor system. Scientific American. 234: 64-6, 71-6. PMID 1251177  1
1975 Maniatis T, Ptashne M, Backman K, Kield D, Flashman S, Jeffrey A, Maurer R. Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell. 5: 109-13. PMID 1095210 DOI: 10.1016/0092-8674(75)90018-5  1
1974 Maniatis T, Ptashne M, Barrell BG, Donelson J. Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature. 250: 394-7. PMID 4854243  1
1974 Maurer R, Maniatis T, Ptashne M. Promoters are in the operators in phage lambda. Nature. 249: 221-3. PMID 4598033  1
1974 Maniatis T, Ptashne M, Maurer R. Control elements in the DNA of bacteriophage lambda. Cold Spring Harbor Symposia On Quantitative Biology. 38: 857-68. PMID 4545512  1
1974 Maniatis T, Venable JH, Lerman LS. The structure of psi DNA. Journal of Molecular Biology. 84: 37-64. PMID 4208607 DOI: 10.1016/0022-2836(74)90211-3  0.84
1973 Maniatis T, Ptashne M. Structure of the lambda operators. Nature. 246: 133-6. PMID 4586104  1
1973 Maniatis T, Ptashne M. Multiple repressor binding at the operators in bacteriophage lambda. Proceedings of the National Academy of Sciences of the United States of America. 70: 1531-5. PMID 4514322  1
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