Carol A. Fierke, Ph. D. - Publications

Affiliations: 
Chemistry, Biological chemsitry University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Enzymology, metalloenzymes, ribozyme, RNA
Website:
http://www.lsa.umich.edu/chem/people/faculty/fierkecarol_ci

236 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Karasik A, Fierke CA, Koutmos M. Interplay between substrate recognition, 5' end tRNA processing and methylation activity of human mitochondrial RNase P. Rna (New York, N.Y.). PMID 31455609 DOI: 10.1261/rna.069310.118  0.48
2019 Nissim S, Leshchiner I, Mancias JD, Greenblatt MB, Maertens O, Cassa CA, Rosenfeld JA, Cox AG, Hedgepeth J, Wucherpfennig JI, Kim AJ, Henderson JE, Gonyo P, Brandt A, Lorimer E, ... ... Fierke CA, et al. Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer. Nature Genetics. PMID 31406347 DOI: 10.1038/s41588-019-0475-y  0.4
2019 García-Torres D, Fierke CA. The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases. The Journal of Biological Chemistry. PMID 31197034 DOI: 10.1074/jbc.RA119.007438  0.52
2019 Sahoo BR, Genjo T, Nakayama TW, Stoddard AK, Ando T, Yasuhara K, Fierke CA, Ramamoorthy A. A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation. Chemical Science. 10: 3976-3986. PMID 31015938 DOI: 10.1039/c8sc05771k  0.6
2018 Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A. Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs. Chemical Communications (Cambridge, England). PMID 30379172 DOI: 10.1039/c8cc07921h  0.6
2018 Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL, Fierke CA, Mapp AK. Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127017 DOI: 10.1073/pnas.1806202115  0.72
2018 Jennings BC, Lawton A, Rizk Z, Fierke CA. SmgGDS-607 regulation of RhoA GTPase prenylation is nucleotide dependent. Biochemistry. PMID 29940100 DOI: 10.1021/acs.biochem.8b00567  0.4
2017 Liu X, Chen Y, Fierke CA. Inner-sphere Coordination of Divalent Metal Ion with Nucleobase in Catalytic RNA. Journal of the American Chemical Society. PMID 29116782 DOI: 10.1021/jacs.7b08755  1
2017 Castaneda CA, Wolfson NA, Leng KR, Kuo YM, Andrews AJ, Fierke CA. Histone deacetylase 8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared to peptides. The Journal of Biological Chemistry. PMID 29109148 DOI: 10.1074/jbc.M117.811026  1
2017 Lopez JE, Haynes SE, Majmudar JD, Martin BR, Fierke CA. HDAC8 substrates identified by genetically-encoded active site photocrosslinking. Journal of the American Chemical Society. PMID 29035536 DOI: 10.1021/jacs.7b07603  1
2017 Niu S, Kim BC, Fierke CA, Ruotolo BT. Ion Mobility-Mass Spectrometry Reveals Evidence of Specific Complex Formation between Human Histone Deacetylase 8 and Poly-r(C)-binding Protein 1. International Journal of Mass Spectrometry. 420: 9-15. PMID 28983190 DOI: 10.1016/j.ijms.2016.12.017  0.36
2017 Castaneda CA, Lopez JE, Joseph CG, Scholle MD, Mrksich M, Fierke CA. Active site metal identity alters HDAC8 substrate selectivity: A potential novel regulatory mechanism. Biochemistry. PMID 28937750 DOI: 10.1021/acs.biochem.7b00851  1
2017 Klemm BP, Karasik A, Kaitany KJ, Shanmuganathan A, Henley MJ, Thelen AZ, Dewar AJ, Jackson ND, Koutmos M, Fierke CA. Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P. Rna (New York, N.Y.). PMID 28874505 DOI: 10.1261/rna.061457.117  0.52
2017 Thompson RB, Fierke CA. Preface. Methods in Enzymology. 589: xvii-xviii. PMID 28336076 DOI: 10.1016/S0076-6879(17)30107-6  0.6
2017 Thompson RB, Fierke CA. Measuring and Imaging Metal Ions With Fluorescence-Based Biosensors: Speciation, Selectivity, Kinetics, and Other Issues. Methods in Enzymology. 589: 281-299. PMID 28336067 DOI: 10.1016/bs.mie.2017.01.003  0.6
2017 Chen Y, Liu X, Wu N, Fierke CA. Fluorescence-Based Real-Time Activity Assays to Identify RNase P Inhibitors. Methods in Molecular Biology (Clifton, N.J.). 1520: 201-225. PMID 27873254 DOI: 10.1007/978-1-4939-6634-9_12  1
2016 Temple KJ, Wright EN, Fierke CA, Gibbs RA. Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues. Organic Letters. 18: 6038-6041. PMID 27934359 DOI: 10.1021/acs.orglett.6b02977  0.92
2016 Temple KJ, Wright EN, Fierke CA, Gibbs RA. Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs. Bioorganic & Medicinal Chemistry Letters. PMID 27342751 DOI: 10.1016/j.bmcl.2016.06.035  0.92
2016 Temple KJ, Wright EN, Fierke CA, Gibbs RA. Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs. Bioorganic & Medicinal Chemistry Letters. PMID 27342750 DOI: 10.1016/j.bmcl.2016.06.034  0.92
2016 Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL. The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. The Journal of Biological Chemistry. 291: 10948. PMID 27197236 DOI: 10.1074/jbc.A115.696831  0.4
2016 Klemm BP, Wu N, Chen Y, Liu X, Kaitany KJ, Howard MJ, Fierke CA. The Diversity of Ribonuclease P: Protein and RNA Catalysts with Analogous Biological Functions. Biomolecules. 6. PMID 27187488 DOI: 10.3390/biom6020027  1
2016 Howard MJ, Karasik A, Klemm BP, Mei C, Shanmuganathan A, Fierke CA, Koutmos M. Differential substrate recognition by isozymes of plant protein-only Ribonuclease P. Rna (New York, N.Y.). PMID 26966150 DOI: 10.1261/rna.055541.115  1
2016 Alam N, Zimmerman L, Wolfson NA, Joseph CG, Fierke CA, Schueler-Furman O. Structure-Based Identification of HDAC8 Non-histone Substrates. Structure (London, England : 1993). 24: 458-68. PMID 26933971 DOI: 10.1016/j.str.2016.02.002  1
2016 Lopez JE, Sullivan ED, Fierke CA. Metal-dependent deacetylases: Cancer and epigenetic regulators. Acs Chemical Biology. PMID 26907466 DOI: 10.1021/acschembio.5b01067  1
2016 Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL. The Tumor Suppressive Small GTPase DiRas1 Binds the Non-canonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. The Journal of Biological Chemistry. PMID 26814130 DOI: 10.1074/jbc.M115.696831  1
2016 Gantt SM, Decroos C, Lee MS, Gullett LE, Bowman CM, Christianson DW, Fierke CA. General Base-General Acid Catalysis in Human Histone Deacetylase 8. Biochemistry. PMID 26806311 DOI: 10.1021/acs.biochem.5b01327  0.44
2016 Pithadia AS, Bhunia A, Sribalan R, Padmini V, Fierke CA, Ramamoorthy A. Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes. Chemical Communications (Cambridge, England). 52: 942-5. PMID 26587568 DOI: 10.1039/c5cc07792c  0.44
2015 Jennings BC, Danowitz AM, Wang YC, Gibbs RA, Distefano MD, Fierke CA. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. Bioorganic & Medicinal Chemistry Letters. PMID 26803203 DOI: 10.1016/j.bmcl.2015.12.079  0.44
2015 Karasik A, Shanmuganathan A, Howard MJ, Fierke CA, Koutmos M. Nuclear Protein-only ribonuclease P 2 Structure and Biochemical Characterization Provide Insight Into the Conserved Properties of tRNA 5'-end Processing Enzymes. Journal of Molecular Biology. PMID 26655022 DOI: 10.1016/j.jmb.2015.11.025  1
2015 Daniel KB, Sullivan ED, Chen Y, Chan JC, Jennings PA, Fierke CA, Cohen SM. Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release. Journal of Medicinal Chemistry. 58: 4812-21. PMID 25974739 DOI: 10.1021/acs.jmedchem.5b00539  1
2015 Howard MJ, Klemm BP, Fierke CA. Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P. The Journal of Biological Chemistry. 290: 13454-64. PMID 25817998 DOI: 10.1074/jbc.M115.644831  1
2015 Ghosh A, Pithadia AS, Bhat J, Bera S, Midya A, Fierke CA, Ramamoorthy A, Bhunia A. Self-assembly of a nine-residue amyloid-forming peptide fragment of SARS corona virus E-protein: mechanism of self aggregation and amyloid-inhibition of hIAPP. Biochemistry. 54: 2249-2261. PMID 25785896 DOI: 10.1021/acs.biochem.5b00061  0.44
2015 Engelke DR, Fierke CA. The evolution of RNase P. Rna (New York, N.Y.). 21: 517-8. PMID 25780121 DOI: 10.1261/rna.050732.115  1
2015 Mustoe AM, Liu X, Lin PJ, Al-Hashimi HM, Fierke CA, Brooks CL. Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding. Journal of the American Chemical Society. 137: 3592-9. PMID 25705930 DOI: 10.1021/ja5130308  1
2015 Kim B, Pithadia AS, Fierke CA. Kinetics and thermodynamics of metal-binding to histone deacetylase 8. Protein Science : a Publication of the Protein Society. 24: 354-65. PMID 25516458 DOI: 10.1002/pro.2623  0.44
2015 Dostál L, Kohler WM, Penner-Hahn JE, Miller RA, Fierke CA. Fibroblasts from long-lived rodent species exclude cadmium. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 70: 10-9. PMID 24522391 DOI: 10.1093/gerona/glu001  1
2015 Chen Z, Coppola BP, Fierke CA. Editorial Chinese Chemical Letters. 26: 393-394. DOI: 10.1016/j.cclet.2015.04.004  1
2014 Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy. The Journal of Physical Chemistry Letters. 5: 1864-70. PMID 26273866 DOI: 10.1021/jz5001775  0.44
2014 Liu X, Chen Y, Fierke CA. A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P. Nucleic Acids Research. 42: e159. PMID 25249623 DOI: 10.1093/nar/gku850  1
2014 Olson DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T, Natoli T, Lu X, Paulk J, McCarren P, Wagner FF, Barker D, Howe E, Lazzaro F, ... ... Fierke CA, et al. An unbiased approach to identify endogenous substrates of "histone" deacetylase 8. Acs Chemical Biology. 9: 2210-6. PMID 25089360 DOI: 10.1021/cb500492r  1
2014 Wang N, Lodge JM, Fierke CA, Mapp AK. Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand. Proceedings of the National Academy of Sciences of the United States of America. 111: 12061-6. PMID 25049401 DOI: 10.1073/pnas.1406033111  1
2014 Wolfson NA, Pitcairn CA, Sullivan ED, Joseph CG, Fierke CA. An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity. Analytical Biochemistry. 456: 61-9. PMID 24674948 DOI: 10.1016/j.ab.2014.03.012  1
2014 McCranor BJ, Szmacinski H, Zeng HH, Stoddard AK, Hurst T, Fierke CA, Lakowicz JR, Thompson RB. Fluorescence lifetime imaging of physiological free Cu(II) levels in live cells with a Cu(II)-selective carbonic anhydrase-based biosensor. Metallomics : Integrated Biometal Science. 6: 1034-42. PMID 24671220 DOI: 10.1039/c3mt00305a  1
2014 Daniels KG, Tonthat NK, McClure DR, Chang YC, Liu X, Schumacher MA, Fierke CA, Schmidler SC, Oas TG. Ligand concentration regulates the pathways of coupled protein folding and binding. Journal of the American Chemical Society. 136: 822-5. PMID 24364358 DOI: 10.1021/ja4086726  1
2014 Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In search of aggregation pathways of IAPP and other amyloidogenic proteins: Finding answers through NMR spectroscopy Journal of Physical Chemistry Letters. 5: 1864-1870. DOI: 10.1021/jz5001775  1
2013 Parisien M, Wang X, Perdrizet G, Lamphear C, Fierke CA, Maheshwari KC, Wilde MJ, Sosnick TR, Pan T. Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface. Cell Reports. 3: 1703-13. PMID 23665222 DOI: 10.1016/j.celrep.2013.04.010  1
2013 Howard MJ, Liu X, Lim WH, Klemm BP, Fierke CA, Koutmos M, Engelke DR. RNase P enzymes: divergent scaffolds for a conserved biological reaction. Rna Biology. 10: 909-14. PMID 23595059 DOI: 10.4161/rna.24513  1
2013 Wang D, Fierke CA. The BaeSR regulon is involved in defense against zinc toxicity in E. coli. Metallomics : Integrated Biometal Science. 5: 372-83. PMID 23446818 DOI: 10.1039/c3mt20217h  1
2013 Zeng HH, Matveeva EG, Stoddard AK, Fierke CA, Thompson RB. Long wavelength fluorescence ratiometric zinc biosensor. Journal of Fluorescence. 23: 375-9. PMID 23345045 DOI: 10.1007/s10895-013-1161-6  1
2013 Wolfson NA, Pitcairn CA, Fierke CA. HDAC8 substrates: Histones and beyond. Biopolymers. 99: 112-26. PMID 23175386 DOI: 10.1002/bip.22135  1
2013 Hernick M, Fierke C. Mechanisms of Metal-Dependent Hydrolases in Metabolism Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. DOI: 10.1016/B978-0-12-409547-2.02882-1  1
2012 Zverina EA, Lamphear CL, Wright EN, Fierke CA. Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions. Current Opinion in Chemical Biology. 16: 544-52. PMID 23141597 DOI: 10.1016/j.cbpa.2012.10.015  1
2012 Hougland JL, Gangopadhyay SA, Fierke CA. Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways. The Journal of Biological Chemistry. 287: 38090-100. PMID 22992747 DOI: 10.1074/jbc.M112.404954  1
2012 Howard MJ, Lim WH, Fierke CA, Koutmos M. Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing. Proceedings of the National Academy of Sciences of the United States of America. 109: 16149-54. PMID 22991464 DOI: 10.1073/pnas.1209062109  1
2012 Subramanian T, Pais JE, Liu S, Troutman JM, Suzuki Y, Leela Subramanian K, Fierke CA, Andres DA, Spielmann HP. Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. Biochemistry. 51: 8307-19. PMID 22989235 DOI: 10.1021/bi3011362  1
2012 Wang D, Hosteen O, Fierke CA. ZntR-mediated transcription of zntA responds to nanomolar intracellular free zinc. Journal of Inorganic Biochemistry. 111: 173-81. PMID 22459916 DOI: 10.1016/j.jinorgbio.2012.02.008  1
2012 McCranor BJ, Bozym RA, Vitolo MI, Fierke CA, Bambrick L, Polster BM, Fiskum G, Thompson RB. Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion. Journal of Bioenergetics and Biomembranes. 44: 253-63. PMID 22430627 DOI: 10.1007/s10863-012-9427-2  1
2012 Cheriyan M, Toone EJ, Fierke CA. Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates. Biochemistry. 51: 1658-68. PMID 22316217 DOI: 10.1021/bi201899b  1
2012 Yang Y, Wang B, Ucisik MN, Cui G, Fierke CA, Merz KM. Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS. Journal of the American Chemical Society. 134: 820-3. PMID 22206225 DOI: 10.1021/ja209650h  1
2012 Wang Y, Liu X, Schneider B, Zverina EA, Russ K, Wijeyesakere SJ, Fierke CA, Richardson RJ, Philbert MA. Mixed inhibition of adenosine deaminase activity by 1,3-dinitrobenzene: a model for understanding cell-selective neurotoxicity in chemically-induced energy deprivation syndromes in brain. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 509-21. PMID 22106038 DOI: 10.1093/toxsci/kfr317  1
2011 Guan X, Fierke CA. Understanding Protein Palmitoylation: Biological Significance and Enzymology. Science China. Chemistry. 54: 1888-1897. PMID 25419213 DOI: 10.1007/s11426-011-4428-2  1
2011 London N, Lamphear CL, Hougland JL, Fierke CA, Schueler-Furman O. Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity. Plos Computational Biology. 7: e1002170. PMID 21998565 DOI: 10.1371/journal.pcbi.1002170  1
2011 Cheriyan M, Walters MJ, Kang BD, Anzaldi LL, Toone EJ, Fierke CA. Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrate. Bioorganic & Medicinal Chemistry. 19: 6447-53. PMID 21944547 DOI: 10.1016/j.bmc.2011.08.056  1
2011 Wang D, Hurst TK, Thompson RB, Fierke CA. Genetically encoded ratiometric biosensors to measure intracellular exchangeable zinc in Escherichia coli. Journal of Biomedical Optics. 16: 087011. PMID 21895338 DOI: 10.1117/1.3613926  0.84
2011 Marvin MC, Walker SC, Fierke CA, Engelke DR. Binding and cleavage of unstructured RNA by nuclear RNase P. Rna (New York, N.Y.). 17: 1429-40. PMID 21665997 DOI: 10.1261/rna.2633611  1
2011 Koutmou KS, Day-Storms JJ, Fierke CA. The RNR motif of B. subtilis RNase P protein interacts with both PRNA and pre-tRNA to stabilize an active conformer. Rna (New York, N.Y.). 17: 1225-35. PMID 21622899 DOI: 10.1261/rna.2742511  1
2011 Haider S, Joseph CG, Neidle S, Fierke CA, Fuchter MJ. On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorganic & Medicinal Chemistry Letters. 21: 2129-32. PMID 21320778 DOI: 10.1016/j.bmcl.2011.01.128  1
2011 Wands AM, Wang N, Lum JK, Hsieh J, Fierke CA, Mapp AK. Transient-state kinetic analysis of transcriptional activator·DNA complexes interacting with a key coactivator. The Journal of Biological Chemistry. 286: 16238-45. PMID 21317429 DOI: 10.1074/jbc.M110.207589  1
2011 Cole KE, Gattis SG, Angell HD, Fierke CA, Christianson DW. Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 . Biochemistry. 50: 258-65. PMID 21171638 DOI: 10.1021/bi101622a  1
2011 Lamphear CL, Zverina EA, Hougland JL, Fierke CA. Global Identification of Protein Prenyltransferase Substrates. Defining the Prenylated Proteome. Enzymes. 29: 207-234. DOI: 10.1016/B978-0-12-381339-8.00012-3  1
2010 Gattis SG, Hernick M, Fierke CA. Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions. The Journal of Biological Chemistry. 285: 33788-96. PMID 20709752 DOI: 10.1074/jbc.M110.147173  1
2010 Dowling DP, Gattis SG, Fierke CA, Christianson DW. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function . Biochemistry. 49: 5048-56. PMID 20545365 DOI: 10.1021/bi1005046  1
2010 Hsieh J, Koutmou KS, Rueda D, Koutmos M, Walter NG, Fierke CA. A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P. Journal of Molecular Biology. 400: 38-51. PMID 20434461 DOI: 10.1016/j.jmb.2010.04.050  1
2010 Hernick M, Gattis SG, Penner-Hahn JE, Fierke CA. Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity. Biochemistry. 49: 2246-55. PMID 20136146 DOI: 10.1021/bi902066t  1
2010 Koutmou KS, Casiano-Negroni A, Getz MM, Pazicni S, Andrews AJ, Penner-Hahn JE, Al-Hashimi HM, Fierke CA. NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. Proceedings of the National Academy of Sciences of the United States of America. 107: 2479-84. PMID 20133747 DOI: 10.1073/pnas.0906319107  1
2010 Gantt SL, Joseph CG, Fierke CA. Activation and inhibition of histone deacetylase 8 by monovalent cations. The Journal of Biological Chemistry. 285: 6036-43. PMID 20029090 DOI: 10.1074/jbc.M109.033399  1
2010 Krzysiak AJ, Aditya AV, Hougland JL, Fierke CA, Gibbs RA. Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates. Bioorganic & Medicinal Chemistry Letters. 20: 767-70. PMID 20005705 DOI: 10.1016/j.bmcl.2009.11.011  1
2010 Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME, Fierke CA. Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P. Journal of Molecular Biology. 396: 195-208. PMID 19932118 DOI: 10.1016/j.jmb.2009.11.039  1
2010 Hougland JL, Hicks KA, Hartman HL, Kelly RA, Watt TJ, Fierke CA. Identification of novel peptide substrates for protein farnesyltransferase reveals two substrate classes with distinct sequence selectivities. Journal of Molecular Biology. 395: 176-90. PMID 19878682 DOI: 10.1016/j.jmb.2009.10.038  1
2010 Hurst TK, Wang D, Thompson RB, Fierke CA. Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives. Biochimica Et Biophysica Acta. 1804: 393-403. PMID 19818877 DOI: 10.1016/j.bbapap.2009.09.031  1
2010 Koutmou KS, Hsieh J, Fierke CA. Kinetic mechanism of bacterial RNase P Protein Reviews. 10: 93-111. DOI: 10.1007/978-1-4419-1142-1-6  1
2009 Hsieh J, Fierke CA. Conformational change in the Bacillus subtilis RNase P holoenzyme--pre-tRNA complex enhances substrate affinity and limits cleavage rate. Rna (New York, N.Y.). 15: 1565-77. PMID 19549719 DOI: 10.1261/rna.1639409  1
2009 Johnson KM, Swenson L, Opipari AW, Reuter R, Zarrabi N, Fierke CA, Börsch M, Glick GD. Mechanistic basis for differential inhibition of the F1Fo-ATPase by aurovertin. Biopolymers. 91: 830-40. PMID 19462418 DOI: 10.1002/bip.21262  1
2009 Hougland JL, Fierke CA. Getting a handle on protein prenylation. Nature Chemical Biology. 5: 197-8. PMID 19295521 DOI: 10.1038/nchembio0409-197  1
2009 Hougland JL, Lamphear CL, Scott SA, Gibbs RA, Fierke CA. Context-dependent substrate recognition by protein farnesyltransferase. Biochemistry. 48: 1691-701. PMID 19199818 DOI: 10.1021/bi801710g  1
2009 Hsieh J, Walker SC, Fierke CA, Engelke DR. Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. Rna (New York, N.Y.). 15: 224-34. PMID 19095620 DOI: 10.1261/rna.1309409  1
2008 Bozym R, Hurst TK, Westerberg N, Stoddard A, Fierke CA, Frederickson CJ, Thompson RB. Determination of zinc using carbonic anhydrase-based fluorescence biosensors. Methods in Enzymology. 450: 287-309. PMID 19152866 DOI: 10.1016/S0076-6879(08)03414-9  1
2008 Dowling DP, Gantt SL, Gattis SG, Fierke CA, Christianson DW. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry. 47: 13554-63. PMID 19053282 DOI: 10.1021/bi801610c  1
2008 Lipton AS, Heck RW, Hernick M, Fierke CA, Ellis PD. Residue ionization in LpxC directly observed by 67Zn NMR spectroscopy. Journal of the American Chemical Society. 130: 12671-9. PMID 18761443 DOI: 10.1021/ja801776c  1
2008 Mason AB, Judson GL, Bravo MC, Edelstein A, Byrne SL, James NG, Roush ED, Fierke CA, Bobst CE, Kaltashov IA, Daughtery MA. Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis. Biochemistry. 47: 9847-55. PMID 18712936 DOI: 10.1021/bi801133d  1
2008 Hernick M, Fierke CA. A method to assay inhibitors of lipopolysaccharide synthesis. Methods in Molecular Medicine. 142: 143-54. PMID 18437312 DOI: 10.1007/978-1-59745-246-5_12  1
2008 Walters MJ, Srikannathasan V, McEwan AR, Naismith JH, Fierke CA, Toone EJ. Characterization and crystal structure of Escherichia coli KDPGal aldolase. Bioorganic & Medicinal Chemistry. 16: 710-20. PMID 17981470 DOI: 10.1016/j.bmc.2007.10.043  1
2008 Andrews AJ, Fierke C. Measuring the Stoichiometry of Magnesium Ions Bound to RNA Handbook of Rna Biochemistry. 250-258. DOI: 10.1002/9783527619504.ch16  1
2007 Inamdar MV, Lastoskie CM, Fierke CA, Sastry AM. Mobile trap algorithm for zinc detection using protein sensors. The Journal of Chemical Physics. 127: 185102. PMID 18020665 DOI: 10.1063/1.2778684  1
2007 Cheriyan M, Toone EJ, Fierke CA. Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates. Protein Science : a Publication of the Protein Society. 16: 2368-77. PMID 17962400 DOI: 10.1110/ps.073042907  1
2007 Smith JK, Hsieh J, Fierke CA. Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis. Biopolymers. 87: 329-38. PMID 17868095 DOI: 10.1002/bip.20846  1
2007 Krzysiak AJ, Scott SA, Hicks KA, Fierke CA, Gibbs RA. Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries. Bioorganic & Medicinal Chemistry Letters. 17: 5548-51. PMID 17804232 DOI: 10.1016/j.bmcl.2007.08.024  1
2007 Krzysiak AJ, Rawat DS, Scott SA, Pais JE, Handley M, Harrison ML, Fierke CA, Gibbs RA. Combinatorial modulation of protein prenylation. Acs Chemical Biology. 2: 385-9. PMID 17530735 DOI: 10.1021/cb700062b  1
2007 Niranjanakumari S, Day-Storms JJ, Ahmed M, Hsieh J, Zahler NH, Venters RA, Fierke CA. Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage. Rna (New York, N.Y.). 13: 521-35. PMID 17299131 DOI: 10.1261/rna.308707  1
2007 Getz MM, Andrews AJ, Fierke CA, Al-Hashimi HM. Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation. Rna (New York, N.Y.). 13: 251-66. PMID 17194721 DOI: 10.1261/rna.264207  1
2007 Fierke CA, Herschlag D. The wide reach of enzymology: from bioorganic chemistry to chemical biology and beyond. [Current Opinion in Chemical Biology 2006, 10:453-454] (DOI:10.1016/j.cbpa.2006.08.019) Current Opinion in Chemical Biology. 11: 111. DOI: 10.1016/j.cbpa.2006.11.001  1
2006 Hernick M, Fierke CA. Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis. Biochemistry. 45: 15240-8. PMID 17176046 DOI: 10.1021/bi061405k  1
2006 Johnson KM, Cleary J, Fierke CA, Opipari AW, Glick GD. Mechanistic basis for therapeutic targeting of the mitochondrial F1F0-ATPase. Acs Chemical Biology. 1: 304-8. PMID 17163759 DOI: 10.1021/cb600143j  1
2006 Bozym RA, Thompson RB, Stoddard AK, Fierke CA. Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor. Acs Chemical Biology. 1: 103-11. PMID 17163650 DOI: 10.1021/cb500043a  1
2006 Hernick M, Fierke CA. Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions. Biochemistry. 45: 14573-81. PMID 17144651 DOI: 10.1021/bi061625y  1
2006 Pais JE, Bowers KE, Fierke CA. Measurement of the alpha-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase. Journal of the American Chemical Society. 128: 15086-7. PMID 17117849 DOI: 10.1021/ja065838m  1
2006 Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW. Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase. Biochemistry. 45: 7940-8. PMID 16800620 DOI: 10.1021/bi060823m  1
2006 Gantt SL, Gattis SG, Fierke CA. Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion. Biochemistry. 45: 6170-8. PMID 16681389 DOI: 10.1021/bi060212u  1
2006 Xiao S, Hsieh J, Nugent RL, Coughlin DJ, Fierke CA, Engelke DR. Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP. Rna (New York, N.Y.). 12: 1023-37. PMID 16618965 DOI: 10.1261/rna.23206  1
2006 Frederickson CJ, Giblin LJ, Krezel A, McAdoo DJ, Mueller RN, Muelle RN, Zeng Y, Balaji RV, Masalha R, Thompson RB, Fierke CA, Sarvey JM, de Valdenebro M, Prough DS, Zornow MH. Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion. Experimental Neurology. 198: 285-93. PMID 16443223 DOI: 10.1016/j.expneurol.2005.08.030  1
2006 Fullerton SW, Griffiths JS, Merkel AB, Cheriyan M, Wymer NJ, Hutchins MJ, Fierke CA, Toone EJ, Naismith JH. Mechanism of the Class I KDPG aldolase. Bioorganic & Medicinal Chemistry. 14: 3002-10. PMID 16403639 DOI: 10.1016/j.bmc.2005.12.022  1
2006 Sumner JP, Westerberg NM, Stoddard AK, Hurst TK, Cramer M, Thompson RB, Fierke CA, Kopelman R. DsRed as a highly sensitive, selective, and reversible fluorescence-based biosensor for both Cu(+) and Cu(2+) ions. Biosensors & Bioelectronics. 21: 1302-8. PMID 16026976 DOI: 10.1016/j.bios.2005.04.023  1
2006 Sumner JP, Westerberg NM, Stoddard AK, Fierke CA, Kopelman R. Cu +- and Cu 2+-sensitive PEBBLE fluorescent nanosensors using DsRed as the recognition element Sensors and Actuators, B: Chemical. 113: 760-767. DOI: 10.1016/j.snb.2005.07.028  1
2006 Fierke CA, Herschlag D. The wide reach of enzymology: from bioorganic chemistry to chemical biology and beyond Mechanisms Current Opinion in Chemical Biology. 10: 453-454. DOI: 10.1016/j.cbpa.2006.08.019  1
2005 Rueda D, Hsieh J, Day-Storms JJ, Fierke CA, Walter NG. The 5' leader of precursor tRNAAsp bound to the Bacillus subtilis RNase P holoenzyme has an extended conformation. Biochemistry. 44: 16130-9. PMID 16331973 DOI: 10.1021/bi0519093  1
2005 Hicks KA, Hartman HL, Fierke CA. Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I. Biochemistry. 44: 15325-33. PMID 16285736 DOI: 10.1021/bi050951v  1
2005 Hartman HL, Hicks KA, Fierke CA. Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity. Biochemistry. 44: 15314-24. PMID 16285735 DOI: 10.1021/bi0509503  1
2005 Pais JE, Bowers KE, Stoddard AK, Fierke CA. A continuous fluorescent assay for protein prenyltransferases measuring diphosphate release. Analytical Biochemistry. 345: 302-11. PMID 16143290 DOI: 10.1016/j.ab.2005.07.040  1
2005 Reigard SA, Zahn TJ, Haworth KB, Hicks KA, Fierke CA, Gibbs RA. Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase. Biochemistry. 44: 11214-23. PMID 16101305 DOI: 10.1021/bi050725l  1
2005 Xiao S, Day-Storms JJ, Srisawat C, Fierke CA, Engelke DR. Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing. Rna (New York, N.Y.). 11: 885-96. PMID 15872187 DOI: 10.1261/rna.7282205  1
2005 Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA. UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism. The Journal of Biological Chemistry. 280: 16969-78. PMID 15705580 DOI: 10.1074/jbc.M413560200  1
2005 Hernick M, Fierke CA. Zinc hydrolases: the mechanisms of zinc-dependent deacetylases. Archives of Biochemistry and Biophysics. 433: 71-84. PMID 15581567 DOI: 10.1016/j.abb.2004.08.006  1
2005 Zeng HH, Bozym RA, Rosenthal RE, Fiskum G, Cotto-Cumba C, Westerberg N, Fierke CA, Stoddard A, Cramer ML, Frederickson CJ, Thompson R. In situ measurement of free zinc in an ischemia model and cell culture using a ratiometric fluorescence-based biosensor Progress in Biomedical Optics and Imaging - Proceedings of Spie. 5692: 51-59. DOI: 10.1117/12.614168  1
2004 Day-Storms JJ, Niranjanakumari S, Fierke CA. Ionic interactions between PRNA and P protein in Bacillus subtilis RNase P characterized using a magnetocapture-based assay. Rna (New York, N.Y.). 10: 1595-608. PMID 15337847 DOI: 10.1261/rna.7550104  1
2004 Griffiths JS, Cheriyan M, Corbell JB, Pocivavsek L, Fierke CA, Toone EJ. A bacterial selection for the directed evolution of pyruvate aldolases. Bioorganic & Medicinal Chemistry. 12: 4067-74. PMID 15246084 DOI: 10.1016/j.bmc.2004.05.034  1
2004 Hartman HL, Bowers KE, Fierke CA. Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium. The Journal of Biological Chemistry. 279: 30546-53. PMID 15131129 DOI: 10.1074/jbc.M403469200  1
2004 Bowers KE, Fierke CA. Positively charged side chains in protein farnesyltransferase enhance catalysis by stabilizing the formation of the diphosphate leaving group. Biochemistry. 43: 5256-65. PMID 15122891 DOI: 10.1021/bi049822p  1
2004 McCall KA, Fierke CA. Probing determinants of the metal ion selectivity in carbonic anhydrase using mutagenesis. Biochemistry. 43: 3979-86. PMID 15049705 DOI: 10.1021/bi0498914  1
2004 Hsieh J, Andrews AJ, Fierke CA. Roles of protein subunits in RNA-protein complexes: lessons from ribonuclease P. Biopolymers. 73: 79-89. PMID 14691942 DOI: 10.1002/bip.10521  1
2004 Bozym RA, Zeng HH, Cramer M, Stoddard A, Fierke CA, Thompson RB. In vivo and intracellular sensing and imaging of free zinc ion Proceedings of Spie - the International Society For Optical Engineering. 5318: 34-38. DOI: 10.1117/12.542329  1
2003 Zeng HH, Thompson RB, Maliwal BP, Fones GR, Moffett JW, Fierke CA. Real-time determination of picomolar free Cu(II) in seawater using a fluorescence-based fiber optic biosensor. Analytical Chemistry. 75: 6807-12. PMID 14670039 DOI: 10.1021/ac0345401  0.32
2003 Pickett JS, Bowers KE, Fierke CA. Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand. The Journal of Biological Chemistry. 278: 51243-50. PMID 14532266 DOI: 10.1074/jbc.M309226200  1
2003 Tobin DA, Pickett JS, Hartman HL, Fierke CA, Penner-Hahn JE. Structural characterization of the zinc site in protein farnesyltransferase. Journal of the American Chemical Society. 125: 9962-9. PMID 12914459 DOI: 10.1021/ja035927o  1
2003 Pickett JS, Bowers KE, Hartman HL, Fu HW, Embry AC, Casey PJ, Fierke CA. Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation. Biochemistry. 42: 9741-8. PMID 12911316 DOI: 10.1021/bi0346852  1
2003 Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW. Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 8146-50. PMID 12819349 DOI: 10.1073/pnas.1432990100  1
2003 McClure CP, Rusche KM, Peariso K, Jackman JE, Fierke CA, Penner-Hahn JE. EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Journal of Inorganic Biochemistry. 94: 78-85. PMID 12620676 DOI: 10.1016/S0162-0134(02)00611-6  1
2003 Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon JE. Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. Proceedings of the National Academy of Sciences of the United States of America. 100: 904-9. PMID 12538863 DOI: 10.1073/pnas.252770599  1
2002 Thompson RB, Cramer ML, Bozym R, Fierke CA. Excitation ratiometric fluorescent biosensor for zinc ion at picomolar levels Journal of Biomedical Optics. 7: 555-560. PMID 12421121 DOI: 10.1117/1.1501886  1
2002 Pirrung MC, Tumey LN, Raetz CR, Jackman JE, Snehalatha K, McClerren AL, Fierke CA, Gantt SL, Rusche KM. Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. Journal of Medicinal Chemistry. 45: 4359-70. PMID 12213077 DOI: 10.1021/jm020183v  1
2002 Ridderstråle Y, Fierke CA, Roush ED, Wistrand PJ. Localization of a protein inhibitor of carbonic anhydrase in pig tissues. Acta Physiologica Scandinavica. 176: 27-31. PMID 12193216 DOI: 10.1046/j.1365-201X.2002.01010.x  1
2002 Crary SM, Kurz JC, Fierke CA. Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P. Rna (New York, N.Y.). 8: 933-47. PMID 12166648 DOI: 10.1017/S1355838202025025  1
2002 Kurz JC, Fierke CA. The affinity of magnesium binding sites in the Bacillus subtilis RNase P x pre-tRNA complex is enhanced by the protein subunit. Biochemistry. 41: 9545-58. PMID 12135377 DOI: 10.1021/bi025553w  1
2002 Chehade KA, Kiegiel K, Isaacs RJ, Pickett JS, Bowers KE, Fierke CA, Andres DA, Spielmann HP. Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase. Journal of the American Chemical Society. 124: 8206-19. PMID 12105898 DOI: 10.1021/ja0124717  1
2002 Xiao S, Scott F, Fierke CA, Engelke DR. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Annual Review of Biochemistry. 71: 165-89. PMID 12045094 DOI: 10.1146/annurev.biochem.71.110601.135352  1
2002 Griffiths JS, Wymer NJ, Njolito E, Niranjanakumari S, Fierke CA, Toone EJ. Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase. Bioorganic & Medicinal Chemistry. 10: 545-50. PMID 11814840 DOI: 10.1016/S0968-0896(01)00307-8  1
2002 Madder RD, Kim CY, Chandra PP, Doyon JB, Baird TA, Fierke CA, Christianson DW, Voet JG, Jain A. Twisted amides inferred from QSAR analysis of hydrophobicity and electronic effects on the affinity of fluoroaromatic inhibitors of carbonic anhydrase. The Journal of Organic Chemistry. 67: 582-4. PMID 11798333 DOI: 10.1021/jo0159385  1
2002 Thompson RB, Zeng HH, Fierke CA, Fones G, Moffett J. Real-time in situ determination of free Cu(II) at picomolar levels in sea water using a fluorescence lifetime-based fiber optic biosensor Proceedings of Spie - the International Society For Optical Engineering. 4625: 137-143. DOI: 10.1117/12.469783  1
2001 Fierke CA, Thompson RB. Fluorescence-based biosensing of zinc using carbonic anhydrase. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 14: 205-22. PMID 11831457 DOI: 10.1023/A:1012980628412  1
2001 Wymer N, Buchanan LV, Henderson D, Mehta N, Botting CH, Pocivavsek L, Fierke CA, Toone EJ, Naismith JH. Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli. Structure (London, England : 1993). 9: 1-9. PMID 11342129 DOI: 10.1016/S0969-2126(00)00555-4  1
2001 DiTusa CA, McCall KA, Christensen T, Mahapatro M, Fierke CA, Toone EJ. Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants. Biochemistry. 40: 5345-51. PMID 11330997 DOI: 10.1021/bi0017327  1
2001 DiTusa CA, Christensen T, McCall KA, Fierke CA, Toone EJ. Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase. Biochemistry. 40: 5338-44. PMID 11330996 DOI: 10.1021/bi001731e  1
2001 Henkels CH, Kurz JC, Fierke CA, Oas TG. Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. Biochemistry. 40: 2777-89. PMID 11258888 DOI: 10.1021/bi002078y  1
2001 Fang XW, Yang XJ, Littrell K, Niranjanakumari S, Thiyagarajan P, Fierke CA, Sosnick TR, Pan T. The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits. Rna (New York, N.Y.). 7: 233-41. PMID 11233980 DOI: 10.1017/S1355838201001352  1
2001 Hightower KE, Casey PJ, Fierke CA. Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase. Biochemistry. 40: 1002-10. PMID 11170422 DOI: 10.1021/bi002237d  1
2001 Jackman JE, Raetz CR, Fierke CA. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site. Biochemistry. 40: 514-23. PMID 11148046 DOI: 10.1021/bi001872g  1
2001 Thompson RB, Zeng HH, Maliwal BP, Fierke CA. Real-time quantitation of cu(II) by a fluorescence-based biosensing approach Proceedings of Spie - the International Society For Optical Engineering. 4252: 12-20. DOI: 10.1117/12.426733  1
2001 Thompson R, Zeng HH, Cramer ML, Fierke CA, Frederickson CJ. Quantitative fluorescence-based biosensing and imaging of zinc and copper in complex media Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-Leos. 1: 194-195.  1
2000 Hunt JA, Lesburg CA, Christianson DW, Thompson RB, Fierke CA. Active-site engineering of carbonic anhydrase and its application to biosensors. Exs. 221-40. PMID 11268518  1
2000 Cox JD, Hunt JA, Compher KM, Fierke CA, Christianson DW. Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry. 39: 13687-94. PMID 11076507 DOI: 10.1021/bi001649j  1
2000 Spence RA, Hightower KE, Terry KL, Beese LS, Fierke CA, Casey PJ. Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition. Biochemistry. 39: 13651-9. PMID 11076503 DOI: 10.1021/bi001084r  1
2000 Saderholm MJ, Hightower KE, Fierke CA. Role of metals in the reaction catalyzed by protein farnesyltransferase. Biochemistry. 39: 12398-405. PMID 11015220 DOI: 10.1021/bi0011781  1
2000 Kurz JC, Fierke CA. Ribonuclease P: a ribonucleoprotein enzyme. Current Opinion in Chemical Biology. 4: 553-8. PMID 11006544 DOI: 10.1016/S1367-5931(00)00131-9  1
2000 McCall KA, Fierke CA. Colorimetric and fluorimetric assays to quantitate micromolar concentrations of transition metals. Analytical Biochemistry. 284: 307-15. PMID 10964414 DOI: 10.1006/abio.2000.4706  1
2000 Doyon JB, Hansen EA, Kim CY, Chang JS, Christianson DW, Madder RD, Voet JG, Baird TA, Fierke CA, Jain A. Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II Organic Letters. 2: 2557-8. PMID 10956546  0.52
2000 Ziehler WA, Day JJ, Fierke CA, Engelke DR. Effects of 5' leader and 3' trailer structures on pre-tRNA processing by nuclear RNase P. Biochemistry. 39: 9909-16. PMID 10933810 DOI: 10.1021/bi000603n  1
2000 Doyon JB, Hansen EA, Kim CY, Chang JS, Christianson DW, Madder RD, Voet JG, Baird TA, Fierke CA, Jain A. Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II. Organic Letters. 2: 1189-92. PMID 10810704  1
2000 McCall KA, Huang C, Fierke CA. Function and mechanism of zinc metalloenzymes. The Journal of Nutrition. 130: 1437S-46S. PMID 10801957  1
2000 Burton RE, Hunt JA, Fierke CA, Oas TG. Novel disulfide engineering in human carbonic anhydrase II using the PAIRWISE side-chain geometry database. Protein Science : a Publication of the Protein Society. 9: 776-85. PMID 10794421 DOI: 10.1110/ps.9.4.776  1
2000 Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs. The Journal of Biological Chemistry. 275: 11002-9. PMID 10753902 DOI: 10.1074/jbc.275.15.11002  1
2000 Thompson RB, Whetsell WO, Maliwal BP, Fierke CA, Frederickson CJ. Fluorescence microscopy of stimulated Zn(II) release from organotypic cultures of mammalian hippocampus using a carbonic anhydrase-based biosensor system. Journal of Neuroscience Methods. 96: 35-45. PMID 10704669 DOI: 10.1016/S0165-0270(99)00183-1  1
2000 Huang C, Hightower KE, Fierke CA. Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state. Biochemistry. 39: 2593-602. PMID 10704208 DOI: 10.1021/bi992356x  1
2000 Kim CY, Chang JS, Doyon JB, Baird TT, Fierke CA, Jain A, Christianson DW. Contribution of fluorine to protein - Ligand affinity in the binding of fluoroaromatic inhibitors to carbonic anhydrase II Journal of the American Chemical Society. 122: 12125-12134. DOI: 10.1021/ja002627n  1
1999 Alber BE, Colangelo CM, Dong J, Stålhandske CM, Baird TT, Tu C, Fierke CA, Silverman DN, Scott RA, Ferry JG. Kinetic and spectroscopic characterization of the gamma-carbonic anhydrase from the methanoarchaeon Methanosarcina thermophila. Biochemistry. 38: 13119-28. PMID 10529183 DOI: 10.1021/bi9828876  1
1999 Hunt JA, Ahmed M, Fierke CA. Metal binding specificity in carbonic anhydrase is influenced by conserved hydrophobic core residues. Biochemistry. 38: 9054-62. PMID 10413479 DOI: 10.1021/bi9900166  1
1999 Hightower KE, Fierke CA. Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase. Current Opinion in Chemical Biology. 3: 176-81. PMID 10226042 DOI: 10.1016/S1367-5931(99)80030-1  1
1999 Ogura T, Inoue K, Tatsuta T, Suzaki T, Karata K, Young K, Su LH, Fierke CA, Jackman JE, Raetz CR, Coleman J, Tomoyasu T, Matsuzawa H. Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli. Molecular Microbiology. 31: 833-44. PMID 10048027 DOI: 10.1046/j.1365-2958.1999.01221.x  1
1999 Jackman JE, Raetz CR, Fierke CA. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme. Biochemistry. 38: 1902-11. PMID 10026271 DOI: 10.1021/bi982339s  1
1999 Thompson RB, Maliwal BP, Fierke CA. Selectivity and sensitivity of fluorescence lifetime-based metal ion biosensing using a carbonic anhydrase transducer. Analytical Biochemistry. 267: 185-95. PMID 9918670 DOI: 10.1006/abio.1998.2991  1
1998 Thompson RB, Maliwal BP, Fierke CA. Expanded dynamic range of free zinc ion determination by fluorescence anisotropy. Analytical Chemistry. 70: 1749-54. PMID 21651269 DOI: 10.1021/ac971199+  1
1998 Zimmerman KK, Scholten JD, Huang CC, Fierke CA, Hupe DJ. High-level expression of rat farnesyl:protein transferase in Escherichia coli as a translationally coupled heterodimer. Protein Expression and Purification. 14: 395-402. PMID 9882574 DOI: 10.1006/prep.1998.0979  1
1998 Niranjanakumari S, Stams T, Crary SM, Christianson DW, Fierke CA. Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA. Proceedings of the National Academy of Sciences of the United States of America. 95: 15212-7. PMID 9860948 DOI: 10.1073/pnas.95.26.15212  1
1998 Thompson RB, Maliwal BP, Feliccia VL, Fierke CA, McCall K. Determination of picomolar concentrations of metal ions using fluorescence anisotropy: biosensing with a "reagentless" enzyme transducer. Analytical Chemistry. 70: 4717-23. PMID 9844569 DOI: 10.1021/ac980864r  1
1998 Hightower KE, Huang CC, Casey PJ, Fierke CA. H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. Biochemistry. 37: 15555-62. PMID 9799520 DOI: 10.1021/bi981525v  1
1998 Loria A, Niranjanakumari S, Fierke CA, Pan T. Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme. Biochemistry. 37: 15466-73. PMID 9799509 DOI: 10.1021/bi9816507  1
1998 Crary SM, Niranjanakumari S, Fierke CA. The protein component of Bacillus subtilis ribonuclease P increases catalytic efficiency by enhancing interactions with the 5' leader sequence of pre-tRNAAsp. Biochemistry. 37: 9409-16. PMID 9649323 DOI: 10.1021/bi980613c  1
1998 Niranjanakumari S, Kurz JC, Fierke CA. Expression, purification and characterization of the recombinant ribonuclease P protein component from Bacillus subtilis. Nucleic Acids Research. 26: 3090-6. PMID 9628904 DOI: 10.1093/nar/26.13.3090  1
1998 Stams T, Niranjanakumari S, Fierke CA, Christianson DW. Ribonuclease P protein structure: evolutionary origins in the translational apparatus. Science (New York, N.Y.). 280: 752-5. PMID 9563955 DOI: 10.1126/science.280.5364.752  1
1998 Kurz JC, Niranjanakumari S, Fierke CA. Protein component of Bacillus subtilis RNase P specifically enhances the affinity for precursor-tRNAAsp. Biochemistry. 37: 2393-400. PMID 9485387 DOI: 10.1021/bi972530m  1
1998 Thompson RB, Maliwal BP, Feliccia V, Fierke CA. High sensitivity determination of Zn(II) and Cu(II) in vitro by fluorescence polarization Proceedings of Spie - the International Society For Optical Engineering. 3259: 40-47. DOI: 10.1117/12.307337  1
1998 Thompson RB, Maliwal BP, Fierke CA. Determination of metal ions by fluorescence anisotropy exhibits a broad dynamic range Proceedings of Spie - the International Society For Optical Engineering. 3256: 51-59. DOI: 10.1117/12.307077  1
1998 Jackman JE, Raetz CRH, Fierke CA. A single zinc is required for UDP-3-O-Acyl-glcnac deacetylase activity Faseb Journal. 12: A1427.  1
1997 Lesburg CA, Huang C, Christianson DW, Fierke CA. Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity. Biochemistry. 36: 15780-91. PMID 9398308 DOI: 10.1021/bi971296x  1
1997 Hunt JA, Fierke CA. Selection of carbonic anhydrase variants displayed on phage. Aromatic residues in zinc binding site enhance metal affinity and equilibration kinetics. The Journal of Biological Chemistry. 272: 20364-72. PMID 9252341 DOI: 10.1074/jbc.272.33.20364  1
1997 Wuebbens MW, Roush ED, Decastro CM, Fierke CA. Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. Biochemistry. 36: 4327-36. PMID 9100029 DOI: 10.1021/bi9627424  1
1997 Baird TT, Waheed A, Okuyama T, Sly WS, Fierke CA. Catalysis and inhibition of human carbonic anhydrase IV. Biochemistry. 36: 2669-78. PMID 9054574 DOI: 10.1021/bi962663s  1
1997 Huang CC, Casey PJ, Fierke CA. Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate. The Journal of Biological Chemistry. 272: 20-3. PMID 8995218 DOI: 10.1074/jbc.272.1.20  1
1997 Thompson RB, Lin HJ, Ge Z, Johnson K, Fierke CA. Fluorescence-lifetime-based determination of anions using a site-directed mutant enzyme transducer Proceedings of Spie - the International Society For Optical Engineering. 2980: 247-257. DOI: 10.1117/12.273524  1
1997 Huang CC, Casey PJ, Fierke CA. Functions of metals in protein farnesyltransferase Faseb Journal. 11: A1307.  1
1997 Fierke CA, Crarv SM, Kurz JC, Niranjanakumari S. Ribonuclease P: Function of magnesium ions and protein subunit Faseb Journal. 11: A852.  1
1997 Niranjanakumari S, Fierke CA. Ribonuclease p: Mapping the binding sites of rna and protein components by photoaffinity crosslinking Faseb Journal. 11: A1407.  1
1996 Thompson RB, Ge Z, Patchan MW, Fierke CA. Performance enhancement of fluorescence energy transfer-based biosensors by site-directed mutagenesis of the transducer. Journal of Biomedical Optics. 1: 131-7. PMID 23014654 DOI: 10.1117/12.227108  1
1996 Venters RA, Farmer BT, Fierke CA, Spicer LD. Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II. Journal of Molecular Biology. 264: 1101-16. PMID 9000633 DOI: 10.1006/jmbi.1996.0699  1
1996 Jackman JE, Merz KM, Fierke CA. Disruption of the active site solvent network in carbonic anhydrase II decreases the efficiency of proton transfer. Biochemistry. 35: 16421-8. PMID 8987973 DOI: 10.1021/bi961786+  1
1996 Beebe JA, Kurz JC, Fierke CA. Magnesium ions are required by Bacillus subtilis ribonuclease P RNA for both binding and cleaving precursor tRNAAsp. Biochemistry. 35: 10493-505. PMID 8756706 DOI: 10.1021/bi960870m  1
1996 Huang CC, Lesburg CA, Kiefer LL, Fierke CA, Christianson DW. Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry. 35: 3439-46. PMID 8639494 DOI: 10.1021/bi9526692  1
1996 Thompson RB, Ge Z, Patchan M, Huang CC, Fierke CA. Fiber optic biosensor for Co(II) and Cu(II) based on fluorescence energy transfer with an enzyme transducer Biosensors and Bioelectronics. 11: 557-564. DOI: 10.1016/0956-5663(96)83291-X  1
1996 Christianson DW, Fierke CA. Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design Accounts of Chemical Research. 29: 331-339.  1
1995 Ippolito JA, Nair SK, Alexander RS, Kiefer LL, Fierke CA, Christianson DW. Structure of His94-->Asp carbonic anhydrase II in a new crystalline form reveals a partially occupied zinc binding site. Protein Engineering. 8: 975-80. PMID 8771178 DOI: 10.1093/protein/8.10.975  1
1995 Puttaraju M, Beebe JA, Niranjanakumari S, Been MD, Fierke CA. Generation and characterization of circular Bacillus subtilis RNase P RNA; activation by RNase P protein. Nucleic Acids Symposium Series. 92-4. PMID 8643411  1
1995 Fierke CA, Hammes GG. Transient kinetic approaches to enzyme mechanisms. Methods in Enzymology. 249: 3-37. PMID 7791616 DOI: 10.1016/0076-6879(95)49029-9  1
1995 Ippolito JA, Baird TT, McGee SA, Christianson DW, Fierke CA. Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proceedings of the National Academy of Sciences of the United States of America. 92: 5017-21. PMID 7761440 DOI: 10.1073/pnas.92.11.5017  1
1995 Nair SK, Krebs JF, Christianson DW, Fierke CA. Structural basis of inhibitor affinity to variants of human carbonic anhydrase II. Biochemistry. 34: 3981-9. PMID 7696263  1
1995 Venters RA, Huang CC, Farmer BT, Trolard R, Spicer LD, Fierke CA. High-level 2H/13C/15N labeling of proteins for NMR studies. Journal of Biomolecular Nmr. 5: 339-44. PMID 7647552 DOI: 10.1007/BF00182275  1
1995 Whitty A, Fierke CA, Jencks WP. Role of binding energy with coenzyme A in catalysis by 3-oxoacid coenzyme A transferase. Biochemistry. 34: 11678-89. PMID 7547900  1
1995 Kiefer LL, Paterno SA, Fierke CA. Hydrogen bond network in the metal binding site of carbonic anhydrase enhances zinc affinity and catalytic efficiency Journal of the American Chemical Society. 117: 6831-6837.  1
1994 Kiefer LL, Fierke CA. Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites Biochemistry. 33: 15233-15240. PMID 7803385  1
1994 Beebe JA, Fierke CA. A kinetic mechanism for cleavage of precursor tRNA(Asp) catalyzed by the RNA component of Bacillus subtilis ribonuclease P. Biochemistry. 33: 10294-304. PMID 7520753  1
1993 Krebs JF, Rana F, Dluhy RA, Fierke CA. Kinetic and spectroscopic studies of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II Biochemistry. 32: 4496-4505. PMID 8485128  1
1993 Krebs JF, Fierke CA. Determinants of catalytic activity and stability of carbonic anhydrase II as revealed by random mutagenesis Journal of Biological Chemistry. 268: 948-954. PMID 8419374  1
1993 Kiefer LL, Krebs JF, Paterno SA, Fierke CA. Engineering a cysteine ligand into the zinc binding site of human carbonic anhydrase II Biochemistry. 32: 9896-9900. PMID 8399158  1
1993 Heming TA, Vanoye CG, Stabenau EK, Roush ED, Fierke CA, Bidani A. Inhibitor sensitivity of pulmonary vascular carbonic anhydrase Journal of Applied Physiology. 75: 1642-1649. PMID 8282615  1
1993 Krebs JF, Ippolito JA, Christianson DW, Fierke CA. Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II Journal of Biological Chemistry. 268: 27458-27466. PMID 8262987  1
1993 Kiefer LL, Ippolito JA, Fierke CA, Christianson DW. Redesigning the zinc binding site of human carbonic anhydrase II: Structure of a His2Asp-Zn2+ metal coordination polyhedron Journal of the American Chemical Society. 115: 12581-12582.  1
1992 Roush ED, Fierke CA. Purification and characterization of a carbonic anhydrase II inhibitor from porcine plasma Biochemistry. 31: 12536-12542. PMID 1463741  1
1991 Nair SK, Calderone TL, Christianson DW, Fierke CA. Altering the mouth of a hydrophobic pocket: Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121 Journal of Biological Chemistry. 266: 17320-17325. PMID 1910042  1
1991 Krebs JF, Fierke CA, Alexander RS, Christianson DW. Conformational mobility of His-64 in the Thr-200 → ser mutant of human carbonic anhydrase II Biochemistry. 30: 9153-9160. PMID 1909891  1
1991 Adams JA, Fierke CA, Benkovic SJ. The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli. Biochemistry. 30: 11046-54. PMID 1834173  1
1991 Fierke CA. Functional consequences of engineering the hydrophobic pocket of carbonic anhydrase II Biochemistry. 30: 11054-11063. PMID 1657158  1
1989 Andrews J, Fierke CA, Birdsall B, Ostler G, Feeney J, Roberts GC, Benkovic SJ. A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei. Biochemistry. 28: 5743-50. PMID 2505841  1
1989 Fierke CA, Benkovic SJ. Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding. Biochemistry. 28: 478-86. PMID 2496745  1
1988 Benkovic SJ, Fierke CA, Naylor AM. Insights into enzyme function from studies on mutants of dihydrofolate reductase. Science (New York, N.Y.). 239: 1105-10. PMID 3125607  1
1987 Fierke CA, Kuchta RD, Johnson KA, Benkovic SJ. Implications for enzymic catalysis from free-energy reaction coordinate profiles. Cold Spring Harbor Symposia On Quantitative Biology. 52: 631-8. PMID 3331348  1
1987 Fierke CA, Johnson KA, Benkovic SJ. Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. Biochemistry. 26: 4085-92. PMID 3307916  1
1986 Mayer RJ, Chen JT, Taira K, Fierke CA, Benkovic SJ. Importance of a hydrophobic residue in binding and catalysis by dihydrofolate reductase. Proceedings of the National Academy of Sciences of the United States of America. 83: 7718-20. PMID 3463995  1
1986 Fierke CA, Jencks WP. Two functional domains of coenzyme A activate catalysis by coenzyme A transferase. Pantetheine and adenosine 3'-phosphate 5'-diphosphate. The Journal of Biological Chemistry. 261: 7603-6. PMID 3458707  1
1985 Chen JT, Mayer RJ, Fierke CA, Benkovic SJ. Site-specific mutagenesis of dihydrofolate reductase from Escherichia coli. Journal of Cellular Biochemistry. 29: 73-82. PMID 3905833 DOI: 10.1002/jcb.240290203  1
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