Paramjit S. Arora, Ph.D. - Publications

Chemistry New York University, New York, NY, United States 
Bioorganic Chemistry

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yoo DY, Hauser AD, Joy ST, Bar-Sagi D, Arora PS. Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics. Acs Chemical Biology. PMID 32378881 DOI: 10.1021/Acschembio.0C00204  0.56
2017 Watkins AM, Craven TW, Renfrew PD, Arora PS, Bonneau R. Rotamer Libraries for the High-Resolution Design of β-Amino Acid Foldamers. Structure (London, England : 1993). PMID 29033287 DOI: 10.1016/J.Str.2017.09.005  0.36
2017 Sawyer N, Watkins AM, Arora PS. Protein Domain Mimics as Modulators of Protein-Protein Interactions. Accounts of Chemical Research. PMID 28561588 DOI: 10.1021/Acs.Accounts.7B00130  0.36
2017 Watkins AM, Bonneau R, Arora PS. Modeling and Design of Peptidomimetics to Modulate Protein-Protein Interactions. Methods in Molecular Biology (Clifton, N.J.). 1561: 291-307. PMID 28236245 DOI: 10.1007/978-1-4939-6798-8_17  0.36
2017 Ghosal K, Colby JM, Das D, Joy ST, Arora PS, Krantz BA. Dynamic phenylalanine clamp interactions define single-channel polypeptide translocation through the anthrax toxin protective antigen channel. Journal of Molecular Biology. PMID 28192089 DOI: 10.1016/J.Jmb.2017.02.005  0.56
2016 Watkins AM, Bonneau R, Arora PS. Side Chain Conformational Preferences Govern Protein- Protein Interactions. Journal of the American Chemical Society. PMID 27483190 DOI: 10.1021/Jacs.6B04892  0.36
2016 Modell AE, Blosser SL, Arora PS. Systematic Targeting of Protein-Protein Interactions. Trends in Pharmacological Sciences. PMID 27267699 DOI: 10.1016/J.Tips.2016.05.008  0.36
2016 Joy ST, Arora PS. An optimal hydrogen-bond surrogate for α-helices. Chemical Communications (Cambridge, England). PMID 27046675 DOI: 10.1039/C6Cc01104G  1
2015 Wuo MG, Mahon AB, Arora PS. An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics. Journal of the American Chemical Society. 137: 11618-21. PMID 26340721 DOI: 10.1021/Jacs.5B05525  1
2015 Watkins AM, Wuo MG, Arora PS. Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs. Journal of the American Chemical Society. 137: 11622-30. PMID 26302018 DOI: 10.1021/Jacs.5B05527  1
2015 Rooklin D, Wang C, Katigbak J, Arora PS, Zhang Y. AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces. Journal of Chemical Information and Modeling. 55: 1585-99. PMID 26225450 DOI: 10.1021/Acs.Jcim.5B00103  1
2015 Raj M, Wu H, Blosser SL, Vittoria MA, Arora PS. Aldehyde capture ligation for synthesis of native Peptide bonds. Journal of the American Chemical Society. 137: 6932-40. PMID 25966041 DOI: 10.1021/Jacs.5B03538  1
2015 Watkins AM, Arora PS. Structure-based inhibition of protein-protein interactions. European Journal of Medicinal Chemistry. 94: 480-8. PMID 25253637 DOI: 10.1016/J.Ejmech.2014.09.047  0.36
2014 Lao BB, Drew K, Guarracino DA, Brewer TF, Heindel DW, Bonneau R, Arora PS. Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions. Journal of the American Chemical Society. 136: 7877-88. PMID 24972345 DOI: 10.1021/Ja502310R  1
2014 Khoury GA, Smadbeck J, Tamamis P, Vandris AC, Kieslich CA, Floudas CA. Forcefield_NCAA: ab initio charge parameters to aid in the discovery and design of therapeutic proteins and peptides with unnatural amino acids and their application to complement inhibitors of the compstatin family. Acs Synthetic Biology. 3: 855-69. PMID 24932669 DOI: 10.1021/Sb400168U  1
2014 Miller SE, Thomson PF, Arora PS. Synthesis of hydrogen-bond surrogate α-helices as inhibitors of protein-protein interactions. Current Protocols in Chemical Biology. 6: 101-16. PMID 24903885 DOI: 10.1002/9780470559277.Ch130202  1
2014 Udomprasert A, Bongiovanni MN, Sha R, Sherman WB, Wang T, Arora PS, Canary JW, Gras SL, Seeman NC. Amyloid fibrils nucleated and organized by DNA origami constructions. Nature Nanotechnology. 9: 537-41. PMID 24880222 DOI: 10.1038/Nnano.2014.102  1
2014 Watkins AM, Arora PS. Anatomy of β-strands at protein-protein interfaces. Acs Chemical Biology. 9: 1747-54. PMID 24870802 DOI: 10.1021/Cb500241Y  1
2014 Lao BB, Grishagin I, Mesallati H, Brewer TF, Olenyuk BZ, Arora PS. In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics. Proceedings of the National Academy of Sciences of the United States of America. 111: 7531-6. PMID 24821806 DOI: 10.1073/Pnas.1402393111  1
2014 Miller SE, Watkins AM, Kallenbach NR, Arora PS. Effects of side chains in helix nucleation differ from helix propagation. Proceedings of the National Academy of Sciences of the United States of America. 111: 6636-41. PMID 24753597 DOI: 10.1073/Pnas.1322833111  1
2014 Xie X, Piao L, Bullock BN, Smith A, Su T, Zhang M, Teknos TN, Arora PS, Pan Q. Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma. Oncogene. 33: 1037-46. PMID 23474763 DOI: 10.1038/Onc.2013.25  1
2013 Nickerson S, Joy ST, Arora PS, Bar-Sagi D. An orthosteric inhibitor of the RAS-SOS interaction. The Enzymes. 34: 25-39. PMID 25034099 DOI: 10.1016/B978-0-12-420146-0.00002-0  1
2013 Kushal S, Lao BB, Henchey LK, Dubey R, Mesallati H, Traaseth NJ, Olenyuk BZ, Arora PS. Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: 15602-7. PMID 24019500 DOI: 10.1073/Pnas.1312473110  1
2013 Bergey CM, Watkins AM, Arora PS. HippDB: a database of readily targeted helical protein-protein interactions. Bioinformatics (Oxford, England). 29: 2806-7. PMID 23958730 DOI: 10.1093/Bioinformatics/Btt483  1
2013 Drew K, Renfrew PD, Craven TW, Butterfoss GL, Chou FC, Lyskov S, Bullock BN, Watkins A, Labonte JW, Pacella M, Kilambi KP, Leaver-Fay A, Kuhlman B, Gray JJ, Bradley P, ... ... Arora PS, et al. Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design. Plos One. 8: e67051. PMID 23869206 DOI: 10.1371/Journal.Pone.0067051  1
2013 Raj M, Bullock BN, Arora PS. Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions. Bioorganic & Medicinal Chemistry. 21: 4051-7. PMID 23267671 DOI: 10.1016/J.Bmc.2012.11.023  1
2013 Mahon AB, Arora PS. Constrained peptide helices Understanding and Exploiting Protein-Protein Interactions as Drug Targets. 63-73. DOI: 10.4155/EBO.13.172  1
2012 Miller SE, Kallenbach NR, Arora PS. Reversible α-helix formation controlled by a hydrogen bond surrogate. Tetrahedron. 68: 4434-4437. PMID 23144512 DOI: 10.1016/J.Tet.2011.12.068  1
2012 Wang X, Bergenfeld I, Arora PS, Canary JW. Reversible redox reconfiguration of secondary structures in a designed peptide. Angewandte Chemie (International Ed. in English). 51: 12099-101. PMID 23109367 DOI: 10.1002/Anie.201206009  1
2012 Patgiri A, Joy ST, Arora PS. Nucleation effects in peptide foldamers. Journal of the American Chemical Society. 134: 11495-502. PMID 22715982 DOI: 10.1021/Ja301953J  1
2012 Mahon AB, Arora PS. End-Capped α-Helices as Modulators of Protein Function. Drug Discovery Today. Technologies. 9: e57-e62. PMID 22712023 DOI: 10.1016/J.Ddtec.2011.07.008  1
2012 Jespersen C, Soragni E, James Chou C, Arora PS, Dervan PB, Gottesfeld JM. Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. Bioorganic & Medicinal Chemistry Letters. 22: 4068-71. PMID 22607671 DOI: 10.1016/J.Bmcl.2012.04.090  1
2012 Henchey LK, Kushal S, Dubey R, Chapman RN, Olenyuk BZ, Arora PS. Correction to Inhibition of Hypoxia Inducible Factor 1-Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix. Journal of the American Chemical Society. 134: 8000. PMID 22540322 DOI: 10.1021/Ja302676M  1
2012 Mahon AB, Arora PS. Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices. Chemical Communications (Cambridge, England). 48: 1416-8. PMID 21952530 DOI: 10.1039/C1Cc14730G  1
2012 Mahon AB, Miller SE, Joy ST, Arora PS. Rational design strategies for developing synthetic inhibitors of helical protein interfaces Topics in Medicinal Chemistry. 8: 197-230. DOI: 10.1007/978-3-642-28965-1_6  1
2011 Bullock BN, Jochim AL, Arora PS. Assessing helical protein interfaces for inhibitor design. Journal of the American Chemical Society. 133: 14220-3. PMID 21846146 DOI: 10.1021/Ja206074J  1
2011 Patgiri A, Yadav KK, Arora PS, Bar-Sagi D. An orthosteric inhibitor of the Ras-Sos interaction. Nature Chemical Biology. 7: 585-7. PMID 21765406 DOI: 10.1038/Nchembio.612  1
2011 Guarracino DA, Bullock BN, Arora PS. Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics. Biopolymers. 95: 1-7. PMID 20882600 DOI: 10.1002/Bip.21546  1
2010 Patgiri A, Menzenski MZ, Mahon AB, Arora PS. Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach. Nature Protocols. 5: 1857-65. PMID 21030960 DOI: 10.1038/Nprot.2010.146  1
2010 Porter JR, Helmers MR, Wang P, Furman JL, Joy ST, Arora PS, Ghosh I. Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2. Chemical Communications (Cambridge, England). 46: 8020-2. PMID 20856941 DOI: 10.1039/C0Cc02969F  1
2010 Henchey LK, Porter JR, Ghosh I, Arora PS. High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex. Chembiochem : a European Journal of Chemical Biology. 11: 2104-7. PMID 20821791 DOI: 10.1002/Cbic.201000378  1
2010 Jochim AL, Arora PS. Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors. Acs Chemical Biology. 5: 919-23. PMID 20712375 DOI: 10.1021/Cb1001747  1
2010 Patgiri A, Witten MR, Arora PS. Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling. Organic & Biomolecular Chemistry. 8: 1773-6. PMID 20449477 DOI: 10.1039/C000905A  1
2010 Tosovská P, Arora PS. Oligooxopiperazines as nonpeptidic alpha-helix mimetics. Organic Letters. 12: 1588-91. PMID 20196543 DOI: 10.1021/Ol1003143  1
2010 Henchey LK, Kushal S, Dubey R, Chapman RN, Olenyuk BZ, Arora PS. Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix. Journal of the American Chemical Society. 132: 941-3. PMID 20041650 DOI: 10.1021/Ja9082864  1
2009 Arora PS, Ansari AZ. Chemical biology: A Notch above other inhibitors. Nature. 462: 171-3. PMID 19907487 DOI: 10.1038/462171A  1
2009 Jochim AL, Miller SE, Angelo NG, Arora PS. Evaluation of triazolamers as active site inhibitors of HIV-1 protease. Bioorganic & Medicinal Chemistry Letters. 19: 6023-6. PMID 19800230 DOI: 10.1016/J.Bmcl.2009.09.049  1
2009 Guarracino DA, Arora PS. Making strides in peptide-based therapeutics. Chemistry & Biology. 16: 919-20. PMID 19778718 DOI: 10.1016/J.Chembiol.2009.09.005  1
2009 Jochim AL, Arora PS. Assessment of helical interfaces in protein-protein interactions. Molecular Biosystems. 5: 924-6. PMID 19668855 DOI: 10.1039/B903202A  1
2009 Bao J, Dong XY, Zhang JZ, Arora PS. Dynamical binding of hydrogen-bond surrogate derived Bak helices to antiapoptotic protein Bcl-xL. The Journal of Physical Chemistry. B. 113: 3565-71. PMID 19231824 DOI: 10.1021/Jp809810Z  1
2008 Henchey LK, Jochim AL, Arora PS. Contemporary strategies for the stabilization of peptides in the alpha-helical conformation. Current Opinion in Chemical Biology. 12: 692-7. PMID 18793750 DOI: 10.1016/J.Cbpa.2008.08.019  1
2008 Kirshenbaum K, Arora PS. Cross-dressing proteins by olefin metathesis. Nature Chemical Biology. 4: 527-8. PMID 18711379 DOI: 10.1038/Nchembio0908-527  1
2008 Patgiri A, Jochim AL, Arora PS. A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation. Accounts of Chemical Research. 41: 1289-300. PMID 18630933 DOI: 10.1021/Ar700264K  1
2008 Chapman R, Kulp JL, Patgiri A, Kallenbach NR, Bracken C, Arora PS. Trapping a folding intermediate of the alpha-helix: stabilization of the pi-helix. Biochemistry. 47: 4189-95. PMID 18335996 DOI: 10.1021/Bi800136M  1
2008 Liu J, Wang D, Zheng Q, Lu M, Arora PS. Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate. Journal of the American Chemical Society. 130: 4334-7. PMID 18331030 DOI: 10.1021/Ja077704U  1
2008 Wang D, Lu M, Arora PS. Inhibition of HIV-1 fusion by hydrogen-bond-surrogate-based alpha helices. Angewandte Chemie (International Ed. in English). 47: 1879-82. PMID 18224636 DOI: 10.1002/Anie.200704227  1
2007 Angelo NG, Arora PS. Solution- and solid-phase synthesis of triazole oligomers that display protein-like functionality. The Journal of Organic Chemistry. 72: 7963-7. PMID 17880241 DOI: 10.1021/Jo701292H  1
2007 Angelo NG, Henchey LK, Waxman AJ, Canary JW, Arora PS, Wink D. Synthesis and characterization of aldol condensation products from unknown aldehydes and ketones. An inquiry-based experiment in the undergraduate laboratory Journal of Chemical Education. 84: 1816-1818. DOI: 10.1021/Ed084P1816  1
2006 Wang D, Chen K, Dimartino G, Arora PS. Nucleation and stability of hydrogen-bond surrogate-based alpha-helices. Organic & Biomolecular Chemistry. 4: 4074-81. PMID 17312961 DOI: 10.1039/B612891B  1
2006 Chapman RN, Arora PS. Optimized synthesis of hydrogen-bond surrogate helices: surprising effects of microwave heating on the activity of Grubbs catalysts. Organic Letters. 8: 5825-8. PMID 17134282 DOI: 10.1021/Ol062443Z  1
2006 Wang D, Chen K, Kulp Iii JL, Arora PS. Evaluation of biologically relevant short alpha-helices stabilized by a main-chain hydrogen-bond surrogate. Journal of the American Chemical Society. 128: 9248-56. PMID 16834399 DOI: 10.1021/Ja062710W  1
2006 Dickinson LA, Burnett R, Melander C, Edelson BS, Arora PS, Dervan PB, Gottesfeld JM. Arresting Cancer Proliferation by Small-Molecule Gene Regulation (DOI:10.1016/j.chembiol.2004.09.004) Chemistry and Biology. 13: 339. DOI: 10.1016/J.Chembiol.2006.02.006  1
2005 Angelo NG, Arora PS. Nonpeptidic foldamers from amino acids: synthesis and characterization of 1,3-substituted triazole oligomers. Journal of the American Chemical Society. 127: 17134-5. PMID 16332031 DOI: 10.1021/Ja056406Z  1
2005 Wang D, Liao W, Arora PS. Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL. Angewandte Chemie (International Ed. in English). 44: 6525-9. PMID 16172999 DOI: 10.1002/Anie.200501603  1
2005 Dimartino G, Wang D, Chapman RN, Arora PS. Solid-phase synthesis of hydrogen-bond surrogate-derived alpha-helices. Organic Letters. 7: 2389-92. PMID 15932205 DOI: 10.1021/Ol0506516  1
2005 Arora PS. Adding specificity to artificial transcription activators. Chemistry & Biology. 12: 262-3. PMID 15797208 DOI: 10.1016/J.Chembiol.2005.03.002  1
2004 Dickinson LA, Burnett R, Melander C, Edelson BS, Arora PS, Dervan PB, Gottesfeld JM. Arresting cancer proliferation by small-molecule gene regulation. Chemistry & Biology. 11: 1583-94. PMID 15556009 DOI: 10.1016/J.Chembiol.2004.09.004  1
2004 Chapman RN, Dimartino G, Arora PS. A highly stable short alpha-helix constrained by a main-chain hydrogen-bond surrogate. Journal of the American Chemical Society. 126: 12252-3. PMID 15453743 DOI: 10.1021/Ja0466659  1
2004 Arora PS, Kirshenbaum K. Nano-tailoring; stitching alterations on viral coats. Chemistry & Biology. 11: 418-20. PMID 15123234 DOI: 10.1016/J.Chembiol.2004.04.003  1
2003 Eisenführ A, Arora PS, Sengle G, Takaoka LR, Nowick JS, Famulok M. A ribozyme with michaelase activity: synthesis of the substrate precursors. Bioorganic & Medicinal Chemistry. 11: 235-49. PMID 12470718 DOI: 10.1016/S0968-0896(02)00311-5  1
2002 Arora PS, Ansari AZ, Best TP, Ptashne M, Dervan PB. Design of artificial transcriptional activators with rigid poly-L-proline linkers. Journal of the American Chemical Society. 124: 13067-71. PMID 12405833 DOI: 10.1021/Ja0208355  1
2002 Belitsky JM, Leslie SJ, Arora PS, Beerman TA, Dervan PB. Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorganic & Medicinal Chemistry. 10: 3313-8. PMID 12150878 DOI: 10.1016/S0968-0896(02)00204-3  1
2001 Sengle G, Eisenführ A, Arora PS, Nowick JS, Famulok M. Novel RNA catalysts for the Michael reaction. Chemistry & Biology. 8: 459-73. PMID 11358693 DOI: 10.1016/S1074-5521(01)00026-6  1
2000 Sengle G, Jenne A, Arora PS, Seelig B, Nowick JS, Jäschke A, Famulok M. Synthesis, incorporation efficiency, and stability of disulfide bridged functional groups at RNA 5'-ends. Bioorganic & Medicinal Chemistry. 8: 1317-29. PMID 10896110 DOI: 10.1016/S0968-0896(00)00080-8  1
1998 Arora PS, Van QN, Famulok M, Shaka AJ, Nowick JS. Design and synthesis of a transition state analogue for the Diels-Alder reaction. Bioorganic & Medicinal Chemistry. 6: 1421-8. PMID 9801813 DOI: 10.1016/S0968-0896(98)00072-8  1
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