Herman O. Sintim, DPhil - Publications

Affiliations: 
Chemistry and Biochemistry University of Maryland, College Park, College Park, MD 
Area:
Chemical Biology, Organic
Website:
http://www.chem.umd.edu/research/facultyprofiles/hermanosintim

109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dayal N, Opoku-Temeng C, Mohammad H, Abutaleb NS, Hernandez D, Onyedibe KI, Wang M, Zeller M, Seleem MN, Sintim HO. Inhibitors of Intracellular Gram-positive Bacteria Growth Synthesized via Povarov-Doebner Reactions. Acs Infectious Diseases. PMID 31512848 DOI: 10.1021/acsinfecdis.9b00022  0.96
2019 Dayal N, Mikek CG, Hernandez D, Naclerio GA, Yin Chu EF, Carter-Cooper BA, Lapidus RG, Sintim HO. Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors. European Journal of Medicinal Chemistry. 180: 449-456. PMID 31330446 DOI: 10.1016/j.ejmech.2019.06.089  0.56
2019 Sintim HO, Al Mamari HH, Almohseni HAA, Fegheh-Hassanpour Y, Hodgson DM. Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids. Beilstein Journal of Organic Chemistry. 15: 1194-1202. PMID 31293666 DOI: 10.3762/bjoc.15.116  0.88
2019 Wang M, Naganna N, Sintim HO. Identification of nicotinamide aminonaphthyridine compounds as potent RET kinase inhibitors and antitumor activities against RET rearranged lung adenocarcinoma. Bioorganic Chemistry. 90: 103052. PMID 31226468 DOI: 10.1016/j.bioorg.2019.103052  0.96
2019 Opoku-Temeng C, Onyedibe KI, Aryal UK, Sintim HO. Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics. Journal of Proteomics. PMID 31028946 DOI: 10.1016/j.jprot.2019.04.018  0.6
2019 Sintim HO, Naclerio GA, Karanja CW, Opoku-Temeng C. Antibacterial small molecules that potently inhibit Staphylococcus aureus lipoteichoic acid biosynthesis. Chemmedchem. PMID 30939229 DOI: 10.1002/cmdc.201900053  0.6
2019 Naganna N, Opoku-Temeng C, Choi EY, Larocque E, Chang ET, Carter-Cooper BA, Wang M, Torregrosa-Allen SE, Elzey BD, Lapidus RG, Sintim HO. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice. Ebiomedicine. PMID 30686755 DOI: 10.1016/j.ebiom.2019.01.012  0.96
2018 Wang M, Sintim HO. Discriminating cyclic from linear nucleotides - CRISPR/Cas-related cyclic hexaadenosine monophosphate as a case study. Analytical Biochemistry. 567: 21-26. PMID 30502320 DOI: 10.1016/j.ab.2018.11.022  0.96
2018 Mikek CG, West SJ, Gwin JC, Dayal N, Sintim HO, Lewis EA. Berenil Binds Tightly to Parallel and Mixed Parallel/Antiparallel G-Quadruplex Motifs with Varied Thermodynamic Signatures. Acs Omega. 3: 11582-11591. PMID 30320266 DOI: 10.1021/acsomega.8b01621  0.56
2018 Fegheh-Hassanpour Y, Arif T, Sintim HO, Al Mamari HH, Hodgson DM. Correction to Synthesis of (-)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition-Rearrangement and Cross-electrophile Coupling. Organic Letters. PMID 30125117 DOI: 10.1021/acs.orglett.8b02330  0.88
2018 Opoku-Temeng C, Naclerio GA, Mohammad H, Dayal N, Abutaleb NS, Seleem MN, Sintim HO. N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria. European Journal of Medicinal Chemistry. 155: 797-805. PMID 29957525 DOI: 10.1016/j.ejmech.2018.06.023  0.6
2018 Almohseni HAA, Al Mamari HH, Valade A, Sintim HO, Hodgson DM. Alkene protection against acid using a bromide substituent: application in a total synthesis of (-)-6,7-dideoxysqualestatin H5. Chemical Communications (Cambridge, England). PMID 29741545 DOI: 10.1039/c8cc02690d  0.88
2018 Opoku-Temeng C, Dayal N, Aflaki Sooreshjani M, Sintim HO. 3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties. Bioorganic Chemistry. 78: 418-426. PMID 29698892 DOI: 10.1016/j.bioorg.2018.03.031  0.6
2018 Opoku-Temeng C, Dayal N, Hernandez DE, Naganna N, Sintim HO. Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor. Chemical Communications (Cambridge, England). PMID 29629444 DOI: 10.1039/c8cc01154k  0.72
2018 Fegheh-Hassanpour Y, Ebrahim F, Arif T, Sintim HO, Claridge TDW, Amin NT, Hodgson DM. On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyl compounds. Organic & Biomolecular Chemistry. PMID 29611856 DOI: 10.1039/c8ob00435h  0.88
2018 Sintim HO, Larocque E, Naganna N, Opoku-Temeng C, Lambrecht A. Alkynylnicotinamide-based compounds as ABL1 inhibitors with potent activities against drug-resistant CML harboring ABL1(T315I) mutant kinase. Chemmedchem. PMID 29608815 DOI: 10.1002/cmdc.201700829  0.72
2018 Wang M, Sooreshjani MA, Mikek C, Opoku-Temeng C, Sintim HO. Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels. Future Medicinal Chemistry. PMID 29558821 DOI: 10.4155/fmc-2017-0322  0.96
2018 Dayal N, Opoku-Temeng C, Hernandez DE, Sooreshjani MA, Carter-Cooper BA, Lapidus RG, Sintim HO. Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines. Future Medicinal Chemistry. PMID 29437468 DOI: 10.4155/fmc-2017-0298  0.6
2017 Opoku-Temeng C, Sintim HO. Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules. Methods in Molecular Biology (Clifton, N.J.). 1657: 419-430. PMID 28889311 DOI: 10.1007/978-1-4939-7240-1_31  0.6
2017 Zhou J, Opoku-Temeng C, Sintim HO. Fluorescent 2-Aminopurine c-di-GMP and GpG Analogs as PDE Probes. Methods in Molecular Biology (Clifton, N.J.). 1657: 245-261. PMID 28889299 DOI: 10.1007/978-1-4939-7240-1_19  0.6
2017 Fegheh-Hassanpour Y, Arif T, Sintim HO, Al Mamari HH, Hodgson DM. Synthesis of (-)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition-Rearrangement and Cross-electrophile Coupling. Organic Letters. PMID 28631488 DOI: 10.1021/acs.orglett.7b01513  0.88
2017 Ma X, Zhou J, Wang C, Carter-Cooper B, Yang F, Larocque E, Fine J, Tsuji G, Chopra G, Lapidus RG, Sintim HO. Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach. Acs Medicinal Chemistry Letters. 8: 492-497. PMID 28523099 DOI: 10.1021/acsmedchemlett.6b00468  0.44
2017 Larocque E, Naganna N, Ma X, Opoku-Temeng C, Carter-Cooper B, Chopra G, Lapidus RG, Sintim HO. Aminoisoquinoline benzamides, FLT3 and Src-family kinase inhibitors, potently inhibit proliferation of acute myeloid leukemia cell lines. Future Medicinal Chemistry. PMID 28490193 DOI: 10.4155/fmc-2017-0067  0.72
2016 Zhou J, Roembke BT, Paragi G, Laguerre A, Sintim HO, Fonseca Guerra C, Monchaud D. Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second messengers. Scientific Reports. 6: 33888. PMID 27667717 DOI: 10.1038/srep33888  1
2016 Subramanian S, Gerasopoulos K, Guo M, Sintim HO, Bentley WE, Ghodssi R. Autoinducer-2 analogs and electric fields - an antibiotic-free bacterial biofilm combination treatment. Biomedical Microdevices. 18: 95. PMID 27647148 DOI: 10.1007/s10544-016-0120-9  1
2016 Opoku-Temeng C, Zhou J, Zheng Y, Su J, Sintim HO. Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules. Chemical Communications (Cambridge, England). PMID 27339003 DOI: 10.1039/c6cc03439j  0.6
2016 Opoku-Temeng C, Sintim HO. Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols. Scientific Reports. 6: 25445. PMID 27150552 DOI: 10.1038/srep25445  0.6
2016 Wang C, Carter-Cooper B, Du Y, Zhou J, Saeed MA, Liu J, Guo M, Roembke B, Mikek C, Lewis EA, Lapidus RG, Sintim HO. Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities. European Journal of Medicinal Chemistry. 118: 266-275. PMID 27132164 DOI: 10.1016/j.ejmech.2016.04.030  1
2016 Opoku-Temeng C, Sintim HO. Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin. Chemical Communications (Cambridge, England). PMID 26824279 DOI: 10.1039/c5cc10446g  0.6
2016 Tsuji G, Sintim HO. Cyclic dinucleotide detection with riboswitch-G-quadruplex hybrid. Molecular Biosystems. PMID 26739090 DOI: 10.1039/c5mb00751h  1
2016 Maa X, Cooper SM, Yanga F, Hu W, Sintim HO. Alkaloid synthesis via carbenoid intermediates Current Organic Chemistry. 20: 82-101.  1
2015 Sintim HO, Gürsoy UK. Biofilms as "Connectors" for Oral and Systems Medicine: A New Opportunity for Biomarkers, Molecular Targets, and Bacterial Eradication. Omics : a Journal of Integrative Biology. PMID 26583256 DOI: 10.1089/omi.2015.0146  1
2015 Siraj N, El-Zahab B, Hamdan S, Karam TE, Haber LH, Li M, Fakayode SO, Das S, Valle B, Strongin RM, Patonay G, Sintim HO, Baker GA, Powe A, Lowry M, et al. Fluorescence, Phosphorescence, and Chemiluminescence. Analytical Chemistry. PMID 26575092 DOI: 10.1021/acs.analchem.5b04109  1
2015 Orr MW, Donaldson GP, Severin GB, Wang J, Sintim HO, Waters CM, Lee VT. Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover. Proceedings of the National Academy of Sciences of the United States of America. 112: E5048-57. PMID 26305945 DOI: 10.1073/pnas.1507245112  1
2015 Rowe I, Guo M, Yasmann A, Cember A, Sintim HO, Sukharev S. Membrane Affinity of Platensimycin and Its Dialkylamine Analogs. International Journal of Molecular Sciences. 16: 17909-32. PMID 26247942 DOI: 10.3390/ijms160817909  1
2015 Rabin N, Zheng Y, Opoku-Temeng C, Du Y, Bonsu E, Sintim HO. Agents that inhibit bacterial biofilm formation. Future Medicinal Chemistry. 7: 647-71. PMID 25921403 DOI: 10.4155/fmc.15.7  1
2015 Rabin N, Zheng Y, Opoku-Temeng C, Du Y, Bonsu E, Sintim HO. Biofilm formation mechanisms and targets for developing antibiofilm agents. Future Medicinal Chemistry. 7: 493-512. PMID 25875875 DOI: 10.4155/fmc.15.6  1
2015 Zargar A, Quan DN, Carter KK, Guo M, Sintim HO, Payne GF, Bentley WE. Bacterial secretions of nonpathogenic Escherichia coli elicit inflammatory pathways: a closer investigation of interkingdom signaling. Mbio. 6: e00025. PMID 25759496 DOI: 10.1128/mBio.00025-15  1
2015 Guo M, Zheng Y, Terell JL, Ad M, Opoku-Temeng C, Bentley WE, Sintim HO. Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators. Chemical Communications (Cambridge, England). 51: 2617-20. PMID 25573337 DOI: 10.1039/c4cc09361e  1
2015 Gordon ON, Luis PB, Sintim HO, Schneider C. Unraveling curcumin degradation: autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione. The Journal of Biological Chemistry. 290: 4817-28. PMID 25564617 DOI: 10.1074/jbc.M114.618785  1
2015 Shen Z, Sintim HO, Semancik S. Rapid nucleic acid melting analyses using a microfabricated electrochemical platform. Analytica Chimica Acta. 853: 265-70. PMID 25467468 DOI: 10.1016/j.aca.2014.10.025  1
2015 Subramanian S, Gerasopoulos K, Sintim HO, Bentley WE, Ghodssi R. A bacterial biofilm combination treatment using a real-time microfluidic platform 2015 Transducers - 2015 18th International Conference On Solid-State Sensors, Actuators and Microsystems, Transducers 2015. 2216-2219. DOI: 10.1109/TRANSDUCERS.2015.7181401  1
2015 Guo M, Zheng Y, Starks R, Opoku-Temeng C, Ma X, Sintim HO. 3-Aminooxazolidinone AHL analogs as hydrolytically-stable quorum sensing agonists in Gram-negative bacteria Medchemcomm. 6: 1086-1092. DOI: 10.1039/c5md00015g  1
2015 Zheng Y, Zhou J, Cooper SM, Opoku-Temeng C, De Brito AM, Sintim HO. Structure-activity relationship studies of c-di-AMP synthase inhibitor, bromophenol-thiohydantoin Tetrahedron. DOI: 10.1016/j.tet.2015.10.073  1
2014 Luo Y, Sintim HO, Dayie TK. Synthesis of a biotinylated photocleavable nucleotide monophosphate for the preparation of natively folded RNAs. Methods in Enzymology. 549: 115-31. PMID 25432747 DOI: 10.1016/B978-0-12-801122-5.00006-4  1
2014 Zheng Y, Sintim HO. Molecular insights into how ligands activate or inactivate LasR. Chemistry & Biology. 21: 1261-3. PMID 25373343 DOI: 10.1016/j.chembiol.2014.10.001  1
2014 Zheng Y, Zhou J, Sayre DA, Sintim HO. Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay. Chemical Communications (Cambridge, England). 50: 11234-7. PMID 25116237 DOI: 10.1039/c4cc02916j  1
2014 Zhou J, Le V, Kalia D, Nakayama S, Mikek C, Lewis EA, Sintim HO. Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding. Molecular Biosystems. 10: 2724-34. PMID 25096593 DOI: 10.1039/c4mb00359d  1
2014 Yan L, Liu K, Sintim HO. Convenient detection of HPV virus in a clinical sample using concurrent rolling circle and junction probe amplifications. Chemical Communications (Cambridge, England). 50: 7147-9. PMID 24852020 DOI: 10.1039/c4cc02532f  1
2014 Roembke BT, Zhou J, Zheng Y, Sayre D, Lizardo A, Bernard L, Sintim HO. A cyclic dinucleotide containing 2-aminopurine is a general fluorescent sensor for c-di-GMP and 3',3'-cGAMP. Molecular Biosystems. 10: 1568-75. PMID 24705858 DOI: 10.1039/c3mb70518h  1
2014 Yan L, Zhou J, Zheng Y, Gamson AS, Roembke BT, Nakayama S, Sintim HO. Isothermal amplified detection of DNA and RNA. Molecular Biosystems. 10: 970-1003. PMID 24643211 DOI: 10.1039/c3mb70304e  1
2014 Zhou J, Sayre DA, Zheng Y, Szmacinski H, Sintim HO. Unexpected complex formation between coralyne and cyclic diadenosine monophosphate providing a simple fluorescent turn-on assay to detect this bacterial second messenger. Analytical Chemistry. 86: 2412-20. PMID 24494631 DOI: 10.1021/ac403203x  1
2014 Luo Y, Chen B, Zhou J, Sintim HO, Dayie TK. E88, a new cyclic-di-GMP class I riboswitch aptamer from Clostridium tetani, has a similar fold to the prototypical class I riboswitch, Vc2, but differentially binds to c-di-GMP analogs. Molecular Biosystems. 10: 384-90. PMID 24430255 DOI: 10.1039/c3mb70467j  1
2014 Adams BL, Carter KK, Guo M, Wu HC, Tsao CY, Sintim HO, Valdes JJ, Bentley WE. Evolved Quorum sensing regulator, LsrR, for altered switching functions. Acs Synthetic Biology. 3: 210-9. PMID 24111753 DOI: 10.1021/sb400068z  1
2014 Wang J, Sintim HO. Antibiotics That Disrupt Cell Wall and Bacterial Membrane Formation and Integrity Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.00016-7  1
2013 Roembke BT, Nakayama S, Sintim HO. Nucleic acid detection using G-quadruplex amplification methodologies. Methods (San Diego, Calif.). 64: 185-98. PMID 24135042 DOI: 10.1016/j.ymeth.2013.10.003  1
2013 Ha JH, Eo Y, Grishaev A, Guo M, Smith JA, Sintim HO, Kim EH, Cheong HK, Bentley WE, Ryu KS. Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogues reveal distinct mechanisms for ligand recognition. Journal of the American Chemical Society. 135: 15526-35. PMID 24047255 DOI: 10.1021/ja407068v  1
2013 Sintim HO, Nakayama S. Detection of single-stranded nucleic acids via colorimetric means, using G-quadruplex probes. Methods in Molecular Biology (Clifton, N.J.). 1039: 153-9. PMID 24026694 DOI: 10.1007/978-1-62703-535-4_13  1
2013 Zheng Y, Sintim HO. "Rolling out" high-molecular-weight proteins, which contain repeating polypeptide motif, by using rolling circle amplification. Chembiochem : a European Journal of Chemical Biology. 14: 1929-30. PMID 24006227 DOI: 10.1002/cbic.201300415  1
2013 Guo M, Gamby S, Zheng Y, Sintim HO. Small molecule inhibitors of AI-2 signaling in bacteria: state-of-the-art and future perspectives for anti-quorum sensing agents. International Journal of Molecular Sciences. 14: 17694-728. PMID 23994835 DOI: 10.3390/ijms140917694  1
2013 Kalia D, Merey G, Guo M, Sintim HO. N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine. The Journal of Organic Chemistry. 78: 6131-42. PMID 23701258 DOI: 10.1021/jo400788a  1
2013 Zhou J, Watt S, Wang J, Nakayama S, Sayre DA, Lam YF, Lee VT, Sintim HO. Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP. Bioorganic & Medicinal Chemistry. 21: 4396-404. PMID 23685177 DOI: 10.1016/j.bmc.2013.04.050  1
2013 Yan L, Nakayama S, Sintim HO. Probe design rules and effective enzymes for endonuclease-based detection of nucleic acids. Bioorganic & Medicinal Chemistry. 21: 6181-5. PMID 23651508 DOI: 10.1016/j.bmc.2013.04.009  1
2013 Luo Y, Zhou J, Wang J, Dayie TK, Sintim HO. Selective binding of 2'-F-c-di-GMP to Ct-E88 and Cb-E43, new class I riboswitches from Clostridium tetani and Clostridium botulinum respectively. Molecular Biosystems. 9: 1535-9. PMID 23559271 DOI: 10.1039/c3mb25560c  1
2013 Roy V, Meyer MT, Smith JA, Gamby S, Sintim HO, Ghodssi R, Bentley WE. AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms. Applied Microbiology and Biotechnology. 97: 2627-38. PMID 23053069 DOI: 10.1007/s00253-012-4404-6  1
2013 Kalia D, Merey G, Nakayama S, Zheng Y, Zhou J, Luo Y, Guo M, Roembke BT, Sintim HO. Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis. Chemical Society Reviews. 42: 305-41. PMID 23023210 DOI: 10.1039/c2cs35206k  1
2013 Shen Z, Sintim HO, Semancik S. Temperature-controlled electrochemical microwell platform for studying biomolecular interactions Ieee Sensors 2013 - Proceedings. DOI: 10.1109/ICSENS.2013.6688368  1
2013 Roembke BT, Wang J, Nakayama S, Zhou J, Sintim HO. Octameric G8 c-di-GMP is an efficient peroxidase and this suggests that an open G-tetrad site can effectively enhance hemin peroxidation reactions Rsc Advances. 3: 6305-6310. DOI: 10.1039/c3ra23308a  1
2012 Zhou J, Sayre DA, Wang J, Pahadi N, Sintim HO. Endo-S-c-di-GMP analogues-polymorphism and binding studies with class I riboswitch. Molecules (Basel, Switzerland). 17: 13376-89. PMID 23143150 DOI: 10.3390/molecules171113376  1
2012 Nakayama S, Sintim HO. Investigating the interactions between cations, peroxidation substrates and G-quadruplex topology in DNAzyme peroxidation reactions using statistical testing. Analytica Chimica Acta. 747: 1-6. PMID 22986129 DOI: 10.1016/j.aca.2012.08.008  1
2012 Nakayama S, Luo Y, Zhou J, Dayie TK, Sintim HO. Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy. Chemical Communications (Cambridge, England). 48: 9059-61. PMID 22854718 DOI: 10.1039/c2cc34379g  1
2012 Guo M, Gamby S, Nakayama S, Smith J, Sintim HO. A pro-drug approach for selective modulation of AI-2-mediated bacterial cell-to-cell communication. Sensors (Basel, Switzerland). 12: 3762-72. PMID 22737036 DOI: 10.3390/s120303762  1
2012 Shen Z, Nakayama S, Semancik S, Sintim HO. Signal-on electrochemical Y or junction probe detection of nucleic acid. Chemical Communications (Cambridge, England). 48: 7580-2. PMID 22735181 DOI: 10.1039/c2cc33280a  1
2012 Wang J, Hudson R, Sintim HO. Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs. Future Medicinal Chemistry. 4: 1113-51. PMID 22709254 DOI: 10.4155/fmc.12.62  1
2012 Gamby S, Roy V, Guo M, Smith JA, Wang J, Stewart JE, Wang X, Bentley WE, Sintim HO. Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues. Acs Chemical Biology. 7: 1023-30. PMID 22433054 DOI: 10.1021/cb200524y  1
2012 Nakayama S, Roelofs K, Lee VT, Sintim HO. A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection. Molecular Biosystems. 8: 726-9. PMID 22252690 DOI: 10.1039/c2mb05430b  1
2012 Kelsey I, Nakayama S, Sintim HO. Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP. Bioorganic & Medicinal Chemistry Letters. 22: 881-5. PMID 22217869 DOI: 10.1016/j.bmcl.2011.12.039  1
2012 Donaldson GP, Roelofs KG, Luo Y, Sintim HO, Lee VT. A rapid assay for affinity and kinetics of molecular interactions with nucleic acids. Nucleic Acids Research. 40: e48. PMID 22210888 DOI: 10.1093/nar/gkr1299  1
2012 Luo Y, Zhou J, Watt SK, Lee VT, Dayie TK, Sintim HO. Differential binding of 2'-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins. Molecular Biosystems. 8: 772-8. PMID 22182995 DOI: 10.1039/c2mb05338a  1
2012 Das S, Powe AM, Baker GA, Valle B, El-Zahab B, Sintim HO, Lowry M, Fakayode SO, McCarroll ME, Patonay G, Li M, Strongin RM, Geng ML, Warner IM. Molecular fluorescence, phosphorescence, and chemiluminescence spectrometry. Analytical Chemistry. 84: 597-625. PMID 22050042 DOI: 10.1021/ac202904n  1
2011 Oduro H, Harms B, Sintim HO, Kaufman AJ, Cody G, Farquhar J. Evidence of magnetic isotope effects during thermochemical sulfate reduction. Proceedings of the National Academy of Sciences of the United States of America. 108: 17635-8. PMID 21997216 DOI: 10.1073/pnas.1108112108  1
2011 Roelofs KG, Wang J, Sintim HO, Lee VT. Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions. Proceedings of the National Academy of Sciences of the United States of America. 108: 15528-33. PMID 21876132 DOI: 10.1073/pnas.1018949108  1
2011 Luo Y, Eldho NV, Sintim HO, Dayie TK. RNAs synthesized using photocleavable biotinylated nucleotides have dramatically improved catalytic efficiency. Nucleic Acids Research. 39: 8559-71. PMID 21742763 DOI: 10.1093/nar/gkr464  1
2011 Kamaraju K, Smith J, Wang J, Roy V, Sintim HO, Bentley WE, Sukharev S. Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules. Biochemistry. 50: 6983-93. PMID 21736305 DOI: 10.1021/bi200684z  1
2011 Wang J, Zhou J, Donaldson GP, Nakayama S, Yan L, Lam YF, Lee VT, Sintim HO. Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins. Journal of the American Chemical Society. 133: 9320-30. PMID 21612220 DOI: 10.1021/ja1112029  1
2011 Nakayama S, Wang J, Sintim HO. DNA-based peroxidation catalyst--what is the exact role of topology on catalysis and is there a special binding site for catalysis? Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 5691-8. PMID 21469226 DOI: 10.1002/chem.201002349  1
2011 Nakayama S, Kelsey I, Wang J, Sintim HO. c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators. Chemical Communications (Cambridge, England). 47: 4766-8. PMID 21399808 DOI: 10.1039/c0cc05432a  1
2011 Nakayama S, Kelsey I, Wang J, Roelofs K, Stefane B, Luo Y, Lee VT, Sintim HO. Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule. Journal of the American Chemical Society. 133: 4856-64. PMID 21384923 DOI: 10.1021/ja1091062  1
2011 Wang J, Sintim HO. Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 3352-7. PMID 21322068 DOI: 10.1002/chem.201002410  1
2011 Yan L, Nakayama S, Yitbarek S, Greenfield I, Sintim HO. Isothermal detection of RNA with restriction endonucleases. Chemical Communications (Cambridge, England). 47: 200-2. PMID 20886171 DOI: 10.1039/c0cc02208j  1
2010 Sintim HO, Smith JA, Wang J, Nakayama S, Yan L. Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules. Future Medicinal Chemistry. 2: 1005-35. PMID 21426116 DOI: 10.4155/fmc.10.185  1
2010 Roy V, Smith JA, Wang J, Stewart JE, Bentley WE, Sintim HO. Synthetic analogs tailor native AI-2 signaling across bacterial species. Journal of the American Chemical Society. 132: 11141-50. PMID 20698680 DOI: 10.1021/ja102587w  1
2010 Wang J, Stefane B, Jaber D, Smith JA, Vickery C, Diop M, Sintim HO. Remote C-H functionalization: using the N-O moiety as an atom-economical tether to obtain 1,5- and the rare 1,7-C-H insertions. Angewandte Chemie (International Ed. in English). 49: 3964-8. PMID 20401885 DOI: 10.1002/anie.201000160  1
2010 Nakayama S, Sintim HO. Biomolecule detection with peroxidase-mimicking DNAzymes; expanding detection modality with fluorogenic compounds. Molecular Biosystems. 6: 95-7. PMID 20024070 DOI: 10.1039/b916228c  1
2009 Jarchow-Choy SK, Sjuvarsson E, Sintim HO, Eriksson S, Kool ET. Nonpolar nucleoside mimics as active substrates for human thymidine kinases. Journal of the American Chemical Society. 131: 5488-94. PMID 20560637 DOI: 10.1021/ja808244t  1
2009 Smith JA, Wang J, Nguyen-Mau SM, Lee V, Sintim HO. Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous. Chemical Communications (Cambridge, England). 7033-5. PMID 19904385 DOI: 10.1039/b909666c  1
2009 Nakayama S, Sintim HO. Colorimetric split G-quadruplex probes for nucleic acid sensing: improving reconstituted DNAzyme's catalytic efficiency via probe remodeling. Journal of the American Chemical Society. 131: 10320-33. PMID 19621970 DOI: 10.1021/ja902951b  1
2009 Wang J, Lee V, Sintim HO. Efforts towards the identification of simpler platensimycin analogues--the total synthesis of oxazinidinyl platensimycin. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 2747-50. PMID 19212990 DOI: 10.1002/chem.200802568  1
2009 Sintim HO, Kool ET. Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine (Journal of the American Chemical Society (2006) 128, (396-397)) Journal of the American Chemical Society. 131: 11270. DOI: 10.1021/ja905423u  1
2008 Nakayama S, Yan L, Sintim HO. Junction probes - sequence specific detection of nucleic acids via template enhanced hybridization processes. Journal of the American Chemical Society. 130: 12560-1. PMID 18759403 DOI: 10.1021/ja803146f  1
2008 Kiburu I, Shurer A, Yan L, Sintim HO. A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues. Molecular Biosystems. 4: 518-20. PMID 18493648 DOI: 10.1039/b719423d  1
2008 Kiburu I, Shurer A, Yan L, Sintim HO. A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues (Molecular BioSystems (2008) 4 (518-520)) Molecular Biosystems. 4: 1220. DOI: 10.1039/b819142p  1
2006 Kool ET, Sintim HO. The difluorotoluene debate--a decade later. Chemical Communications (Cambridge, England). 3665-75. PMID 17047807 DOI: 10.1039/b605414e  1
2006 Sintim HO, Kool ET. Remarkable sensitivity to DNA base shape in the DNA polymerase active site. Angewandte Chemie (International Ed. in English). 45: 1974-9. PMID 16506248 DOI: 10.1002/anie.200504296  1
2006 Sintim HO, Kool ET. Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine. Journal of the American Chemical Society. 128: 396-7. PMID 16402811 DOI: 10.1021/ja0562447  1
2005 Donohoe TJ, Sintim HO, Hollinshead J. A noncarbohydrate based approach to polyhydroxylated pyrrolidizines: total syntheses of the natural products hyacinthacine A1 and 1-epiaustraline. The Journal of Organic Chemistry. 70: 7297-304. PMID 16122251 DOI: 10.1021/jo050977s  1
2005 Donohoe TJ, Sintim HO, Sisangia L, Ace KW, Guyo PM, Cowley A, Harling JD. Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-lactone. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 4227-38. PMID 15864801 DOI: 10.1002/chem.200401119  1
2004 Donohoe TJ, Sintim HO. A concise total synthesis of (+/-)-1-epiaustraline. Organic Letters. 6: 2003-6. PMID 15176804 DOI: 10.1021/ol049397s  1
2004 Donohoe TJ, Sintim HO, Sisangia L, Harling JD. An efficient synthesis of lactacystin beta-lactone. Angewandte Chemie (International Ed. in English). 43: 2293-6. PMID 15108149 DOI: 10.1002/anie.200453843  1
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