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Anna K. Mapp, Ph.D. - Publications

Chemistry, Medicinal Chemsitry University of Michigan, Ann Arbor, Ann Arbor, MI 
Chemical biology

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Henley MJ, Linhares BM, Morgan BS, Cierpicki T, Fierke CA, Mapp AK. Unexpected specificity within dynamic transcriptional protein-protein complexes. Proceedings of the National Academy of Sciences of the United States of America. PMID 33077600 DOI: 10.1073/pnas.2013244117  0.56
2019 Joiner CM, Breen ME, Mapp AK. Electron-deficient p-benzoyl-L-phenylalanine derivatives increase covalent chemical capture yields for protein-protein interactions. Protein Science : a Publication of the Protein Society. PMID 30977234 DOI: 10.1002/pro.3621  0.44
2018 Rabuck-Gibbons JN, Lodge JM, Mapp AK, Ruotolo BT. Collision-Induced Unfolding Reveals Unique Fingerprints for Remote Protein Interaction Sites in the KIX Regulation Domain. Journal of the American Society For Mass Spectrometry. PMID 30136215 DOI: 10.1007/s13361-018-2043-6  0.4
2018 Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL, Fierke CA, Mapp AK. Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127017 DOI: 10.1073/pnas.1806202115  0.56
2018 Kersten KM, Breen ME, Mapp AK, Matzger AJ. Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide. Chemical Communications (Cambridge, England). PMID 30059090 DOI: 10.1039/c8cc04530e  0.44
2018 Breen ME, Mapp AK. Modulating the masters: chemical tools to dissect CBP and p300 function. Current Opinion in Chemical Biology. 45: 195-203. PMID 30025258 DOI: 10.1016/j.cbpa.2018.06.005  0.44
2018 Lodge JM, Majmudar CY, Clayton J, Mapp AK. Covalent chemical co-chaperones of the p300/CBP GACKIX domain. Chembiochem : a European Journal of Chemical Biology. PMID 29939485 DOI: 10.1002/cbic.201800173  1
2018 Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, ... ... Mapp AK, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorganic & Medicinal Chemistry. PMID 29776834 DOI: 10.1016/j.bmc.2018.05.003  0.36
2017 Pricer R, Gestwicki JE, Mapp AK. From Fuzzy to Function: The New Frontier of Protein-Protein Interactions. Accounts of Chemical Research. 50: 584-589. PMID 28945413 DOI: 10.1021/acs.accounts.6b00565  0.48
2016 Joiner CM, Breen ME, Clayton J, Mapp AK. A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of in Vivo Protein-Protein Interactions. Chembiochem : a European Journal of Chemical Biology. PMID 27966261 DOI: 10.1002/cbic.201600578  0.44
2016 Dugan A, Majmudar CY, Pricer RE, Niessen S, Lancia JK, Fung HY, Cravatt BF, Mapp AK. Discovery of enzymatic targets of transcriptional activators via in vivo covalent chemical capture. Journal of the American Chemical Society. PMID 27611834 DOI: 10.1021/jacs.6b07680  1
2016 Dugan A, Pricer R, Katz M, Mapp AK. TRIC: Capturing the direct cellular targets of promoter-bound transcriptional activators. Protein Science : a Publication of the Protein Society. PMID 27213278 DOI: 10.1002/pro.2951  0.56
2015 Mapp AK, Pricer R, Sturlis S. Targeting transcription is no longer a quixotic quest. Nature Chemical Biology. 11: 891-4. PMID 26575226 DOI: 10.1038/nchembio.1962  1
2015 Zhang M, Piao L, Datta J, Lang JC, Xie X, Teknos TN, Mapp AK, Pan Q. miR-124 regulates the epithelial-restricted with serine box/epidermal growth factor receptor signaling axis in head and neck squamous cell carcinoma. Molecular Cancer Therapeutics. PMID 26227488 DOI: 10.1158/1535-7163.MCT-14-1071  1
2014 Wang N, Lodge JM, Fierke CA, Mapp AK. Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand. Proceedings of the National Academy of Sciences of the United States of America. 111: 12061-6. PMID 25049401 DOI: 10.1073/pnas.1406033111  1
2014 Law SM, Gagnon JK, Mapp AK, Brooks CL. Prepaying the entropic cost for allosteric regulation in KIX. Proceedings of the National Academy of Sciences of the United States of America. 111: 12067-72. PMID 25002472 DOI: 10.1073/pnas.1405831111  1
2014 Lodge JM, Rettenmaier TJ, Wells JA, Pomerantz WC, Mapp AK. FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions. Medchemcomm. 5: 370-375. PMID 24795804 DOI: 10.1039/C3MD00356F  1
2014 Højfeldt JW, Cruz-Rodríguez O, Imaeda Y, Van Dyke AR, Carolan JP, Mapp AK, Iñiguez-Lluhí JA. Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor. Molecular Endocrinology (Baltimore, Md.). 28: 249-59. PMID 24422633 DOI: 10.1210/me.2013-1343  1
2014 Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH. The role of HTS in drug discovery at the University of Michigan. Combinatorial Chemistry & High Throughput Screening. 17: 210-30. PMID 24409957 DOI: 10.2174/1386207317666140109121546  1
2014 Lancia JK, Nwokoye A, Dugan A, Joiner C, Pricer R, Mapp AK. Sequence context and crosslinking mechanism affect the efficiency of in vivo capture of a protein-protein interaction. Biopolymers. 101: 391-7. PMID 24037947 DOI: 10.1002/bip.22395  1
2014 Xie X, Piao L, Cavey GS, Old M, Teknos TN, Mapp AK, Pan Q. Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis. Oncogene. 33: 2040-52. PMID 23708658 DOI: 10.1038/onc.2013.173  1
2013 Merrins MJ, Van Dyke AR, Mapp AK, Rizzo MA, Satin LS. Direct measurements of oscillatory glycolysis in pancreatic islet β-cells using novel fluorescence resonance energy transfer (FRET) biosensors for pyruvate kinase M2 activity. The Journal of Biological Chemistry. 288: 33312-22. PMID 24100037 DOI: 10.1074/jbc.M113.508127  1
2013 Zhang M, Taylor CE, Piao L, Datta J, Bruno PA, Bhave S, Su T, Lang JC, Xie X, Teknos TN, Mapp AK, Pan Q. Genetic and chemical targeting of epithelial-restricted with serine box reduces EGF receptor and potentiates the efficacy of afatinib. Molecular Cancer Therapeutics. 12: 1515-25. PMID 23723125 DOI: 10.1158/1535-7163.MCT-12-1110  1
2013 Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL, Wells JA, Mapp AK. Ordering a dynamic protein via a small-molecule stabilizer. Journal of the American Chemical Society. 135: 3363-6. PMID 23384013 DOI: 10.1021/ja3122334  1
2012 Majmudar CY, Højfeldt JW, Arevang CJ, Pomerantz WC, Gagnon JK, Schultz PJ, Cesa LC, Doss CH, Rowe SP, Vásquez V, Tamayo-Castillo G, Cierpicki T, Brooks CL, Sherman DH, Mapp AK. Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. Angewandte Chemie (International Ed. in English). 51: 11258-62. PMID 23042634 DOI: 10.1002/anie.201206815  1
2012 Thompson AD, Dugan A, Gestwicki JE, Mapp AK. Fine-tuning multiprotein complexes using small molecules. Acs Chemical Biology. 7: 1311-20. PMID 22725693 DOI: 10.1021/cb300255p  1
2012 Pomerantz WC, Wang N, Lipinski AK, Wang R, Cierpicki T, Mapp AK. Profiling the dynamic interfaces of fluorinated transcription complexes for ligand discovery and characterization. Acs Chemical Biology. 7: 1345-50. PMID 22725662 DOI: 10.1021/cb3002733  1
2012 Taylor CE, Pan Q, Mapp AK. Synergistic enhancement of the potency and selectivity of small molecule transcriptional inhibitors. Acs Medicinal Chemistry Letters. 3: 30-34. PMID 22368762 DOI: 10.1021/ml200186r  1
2011 Krishnamurthy M, Dugan A, Nwokoye A, Fung YH, Lancia JK, Majmudar CY, Mapp AK. Caught in the act: covalent cross-linking captures activator-coactivator interactions in vivo. Acs Chemical Biology. 6: 1321-6. PMID 21977905 DOI: 10.1021/cb200308e  1
2011 Højfeldt JW, Van Dyke AR, Mapp AK. Transforming ligands into transcriptional regulators: building blocks for bifunctional molecules. Chemical Society Reviews. 40: 4286-94. PMID 21701709 DOI: 10.1039/c1cs15050b  1
2011 Wands AM, Wang N, Lum JK, Hsieh J, Fierke CA, Mapp AK. Transient-state kinetic analysis of transcriptional activator·DNA complexes interacting with a key coactivator. The Journal of Biological Chemistry. 286: 16238-45. PMID 21317429 DOI: 10.1074/jbc.M110.207589  1
2011 Mapp A. Human disease and transcriptional misregulation have strengthened Biopolymers. 95: iii. PMID 21031499  1
2011 Bates CA, Pomerantz WC, Mapp AK. Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators. Biopolymers. 95: 17-23. PMID 20882601 DOI: 10.1002/bip.21548  1
2011 Mapp A. Editorial Biopolymers. 95: iii. DOI: 10.1002/bip.21554  1
2010 Danowitz AM, Taylor CE, Shrikian TM, Mapp AK. Palladium-catalyzed [3,3]-rearrangement for the facile synthesis of allenamides. Organic Letters. 12: 2574-7. PMID 20438110 DOI: 10.1021/ol1007845  1
2010 Lee LW, Mapp AK. Transcriptional switches: chemical approaches to gene regulation. The Journal of Biological Chemistry. 285: 11033-8. PMID 20147748 DOI: 10.1074/jbc.R109.075044  1
2009 Lee LW, Taylor CE, Desaulniers JP, Zhang M, Højfeldt JW, Pan Q, Mapp AK. Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics. Bioorganic & Medicinal Chemistry Letters. 19: 6233-6. PMID 19782563 DOI: 10.1016/j.bmcl.2009.08.090  1
2009 Majmudar CY, Lee LW, Lancia JK, Nwokoye A, Wang Q, Wands AM, Wang L, Mapp AK. Impact of nonnatural amino acid mutagenesis on the in vivo function and binding modes of a transcriptional activator. Journal of the American Chemical Society. 131: 14240-2. PMID 19764747 DOI: 10.1021/ja904378z  1
2009 Majmudar CY, Wang B, Lum JK, Håkansson K, Mapp AK. A high-resolution interaction map of three transcriptional activation domains with a key coactivator from photo-cross-linking and multiplexed mass spectrometry. Angewandte Chemie (International Ed. in English). 48: 7021-4. PMID 19681084 DOI: 10.1002/anie.200902669  1
2009 Bao L, Gorin MA, Zhang M, Ventura AC, Pomerantz WC, Merajver SD, Teknos TN, Mapp AK, Pan Q. Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer. Cancer Research. 69: 5829-34. PMID 19567682 DOI: 10.1158/0008-5472.CAN-08-3465  1
2009 Majmudar CY, Labut AE, Mapp AK. Tra1 as a screening target for transcriptional activation domain discovery. Bioorganic & Medicinal Chemistry Letters. 19: 3733-5. PMID 19497740 DOI: 10.1016/j.bmcl.2009.05.045  1
2009 Aminoff D, Bochar DA, Fuller AA, Mapp AK, Showalter HD, Kirchhoff PD. Research into selective biomarkers of erythrocyte exposure to organophosphorus compounds. Analytical Biochemistry. 392: 155-61. PMID 19497294 DOI: 10.1016/j.ab.2009.05.049  1
2009 Buhrlage SJ, Bates CA, Rowe SP, Minter AR, Brennan BB, Majmudar CY, Wemmer DE, Al-Hashimi H, Mapp AK. Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors. Acs Chemical Biology. 4: 335-44. PMID 19348463 DOI: 10.1021/cb900028j  1
2009 Casey RJ, Desaulniers JP, Hojfeldt JW, Mapp AK. Expanding the repertoire of small molecule transcriptional activation domains. Bioorganic & Medicinal Chemistry. 17: 1034-43. PMID 18334300 DOI: 10.1016/j.bmc.2008.02.045  1
2009 Buhrlage SJ, Chen B, Mapp AK. A flexible synthetic route to isoxazolidine β-proline analogs Tetrahedron. 65: 3305-3313. DOI: 10.1016/j.tet.2008.12.062  1
2008 Mapp A, Romesberg FE. Several novel approaches to developing therapeutics that target both bacterial and human proteins. Current Opinion in Chemical Biology. 12: 387-8. PMID 18707019 DOI: 10.1016/j.cbpa.2008.08.003  1
2008 Rowe SP, Mapp AK. Assessing the permissiveness of transcriptional activator binding sites. Biopolymers. 89: 578-81. PMID 18253946 DOI: 10.1002/bip.20946  1
2007 Rowe SP, Casey RJ, Brennan BB, Buhrlage SJ, Mapp AK. Transcriptional up-regulation in cells mediated by a small molecule. Journal of the American Chemical Society. 129: 10654-5. PMID 17691790 DOI: 10.1021/ja0736865  1
2007 Lum JK, Wu Z, Mapp AK. Disrupting mediator with a short peptide ligand. Chembiochem : a European Journal of Chemical Biology. 8: 1233-6. PMID 17583546 DOI: 10.1002/cbic.200700062  1
2007 Mapp AK, Ansari AZ. A TAD further: exogenous control of gene activation. Acs Chemical Biology. 2: 62-75. PMID 17243784 DOI: 10.1021/cb600463w  1
2006 Lum JK, Majmudar CY, Ansari AZ, Mapp AK. Converting inactive peptides into potent transcriptional activators. Acs Chemical Biology. 1: 639-43. PMID 17175579 DOI: 10.1021/cb600363n  1
2006 Bucholtz TJ, Palfey B, Mapp AK, Glick GD. Graduate education chemical biology at the University of Michigan. Acs Chemical Biology. 1: 487-8. PMID 17168532 DOI: 10.1021/cb600315r  1
2006 Ferguson ML, Senecal TD, Groendyke TM, Mapp AK. [3,3]-rearrangements of phosphonium ylides. Journal of the American Chemical Society. 128: 4576-7. PMID 16594686 DOI: 10.1021/ja058746q  1
2005 Buhrlage SJ, Brennan BB, Minter AR, Mapp AK. Stereochemical promiscuity in artificial transcriptional activators. Journal of the American Chemical Society. 127: 12456-7. PMID 16144370 DOI: 10.1021/ja0536567  1
2005 Majmudar CY, Mapp AK. Chemical approaches to transcriptional regulation. Current Opinion in Chemical Biology. 9: 467-74. PMID 16122970 DOI: 10.1016/j.cbpa.2005.08.012  1
2005 Lum JK, Mapp AK. Artificial transcriptional activation domains. Chembiochem : a European Journal of Chemical Biology. 6: 1311-5. PMID 15973758 DOI: 10.1002/cbic.200500036  1
2005 Lu Z, Rowe SP, Brennan BB, Davis SE, Metzler RE, Nau JJ, Majmudar CY, Mapp AK, Ansari AZ. Unraveling the mechanism of a potent transcriptional activator. The Journal of Biological Chemistry. 280: 29689-98. PMID 15886204 DOI: 10.1074/jbc.M504895200  1
2005 Chen B, Mapp AK. Thermal and catalyzed [3,3]-phosphorimidate rearrangements. Journal of the American Chemical Society. 127: 6712-8. PMID 15869293 DOI: 10.1021/ja050759g  1
2005 Fuller AA, Chen B, Minter AR, Mapp AK. Succinct synthesis of beta-amino acids via chiral isoxazolines. Journal of the American Chemical Society. 127: 5376-83. PMID 15826175 DOI: 10.1021/ja0431713  1
2005 Majmudar CY, Lum JK, Prasov L, Mapp AK. Functional specificity of artificial transcriptional activators. Chemistry & Biology. 12: 313-21. PMID 15797215 DOI: 10.1016/j.chembiol.2005.01.014  1
2004 Mapp AK. Finding their groove; bifunctional molecules arrest growth of cancer cells. Chemistry & Biology. 11: 1480-2. PMID 15555997 DOI: 10.1016/j.chembiol.2004.11.002  1
2004 Minter AR, Brennan BB, Mapp AK. A small molecule transcriptional activation domain. Journal of the American Chemical Society. 126: 10504-5. PMID 15327284 DOI: 10.1021/ja0473889  1
2004 Chen B, Mapp AK. A phosphorimidate rearrangement for the facile and selective preparation of allylic amines. Journal of the American Chemical Society. 126: 5364-5. PMID 15113200 DOI: 10.1021/ja0490469  1
2004 Fuller AA, Chen B, Minter AR, Mapp AK. Synthesis and structural characteristics of geminally disubstituted β-amino acids Synlett. 1409-1413.  1
2003 Wu Z, Belanger G, Brennan BB, Lum JK, Minter AR, Rowe SP, Plachetka A, Majmudar CY, Mapp AK. Targeting the transcriptional machinery with unique artificial transcriptional activators. Journal of the American Chemical Society. 125: 12390-1. PMID 14531665 DOI: 10.1021/ja036685v  1
2003 Mapp AK. Regulating transcription: a chemical perspective. Organic & Biomolecular Chemistry. 1: 2217-20. PMID 12945688 DOI: 10.1039/b302656f  1
2003 Minter AR, Fuller AA, Mapp AK. A concise approach to structurally diverse beta-amino acids. Journal of the American Chemical Society. 125: 6846-7. PMID 12783519 DOI: 10.1021/ja0298747  1
2002 Ansari AZ, Mapp AK. Modular design of artificial transcription factors. Current Opinion in Chemical Biology. 6: 765-72. PMID 12470729 DOI: 10.1016/S1367-5931(02)00377-0  1
2001 Ansari AZ, Mapp AK, Nguyen DH, Dervan PB, Ptashne M. Towards a minimal motif for artificial transcriptional activators. Chemistry & Biology. 8: 583-92. PMID 11410377 DOI: 10.1016/S1074-5521(01)00037-0  1
2000 Mapp AK, Ansari AZ, Ptashne M, Dervan PB. Activation of gene expression by small molecule transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 97: 3930-5. PMID 10760265 DOI: 10.1073/pnas.97.8.3930  1
2000 Mapp AK, Dervan PB. Preparation of thioesters for the ligation of peptides with non-native substrates Tetrahedron Letters. 41: 9451-9454. DOI: 10.1016/S0040-4039(00)01600-2  1
1999 Mapp AK, Heathcock CH. Total Synthesis of Myxalamide A. The Journal of Organic Chemistry. 64: 23-27. PMID 11674080 DOI: 10.1021/jo9813742  1
1996 Marshall KA, Mapp AK, Heathcock CH. Synthesis of a 2,7-dioxatricyclo[,8]nonane: A model study for possible application in a synthesis of dictyoxetane Journal of Organic Chemistry. 61: 9135-9145. DOI: 10.1021/jo961680k  1
1996 Caron S, Stoermer D, Mapp AK, Heathcock CH. Total synthesis of zaragozic acid A (squalestatin S1). Synthesis of the relay compound Journal of Organic Chemistry. 61: 9126-9134. DOI: 10.1021/jo961534e  1
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