Andrew Scharenberg - Publications

Affiliations: 
Immunology University of Washington, Seattle, Seattle, WA 
Area:
Molecular Biology, Biochemistry, Immunology

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Humbert O, Radtke S, Samuelson C, Carrillo RR, Perez AM, Reddy SS, Lux C, Pattabhi S, Schefter LE, Negre O, Lee CM, Bao G, Adair JE, Peterson CW, Rawlings DJ, ... Scharenberg AM, et al. Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates. Science Translational Medicine. 11. PMID 31366580 DOI: 10.1126/scitranslmed.aaw3768  0.36
2019 Pattabhi S, Lotti SN, Berger MP, Singh S, Lux CT, Jacoby K, Lee C, Negre O, Scharenberg AM, Rawlings DJ. In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods. Molecular Therapy. Nucleic Acids. 17: 277-288. PMID 31279229 DOI: 10.1016/j.omtn.2019.05.025  0.36
2019 Lux CT, Pattabhi S, Berger M, Nourigat C, Flowers DA, Negre O, Humbert O, Yang JG, Lee C, Jacoby K, Bernstein I, Kiem HP, Scharenberg A, Rawlings DJ. TALEN-Mediated Gene Editing of in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction. Molecular Therapy. Methods & Clinical Development. 12: 175-183. PMID 30705922 DOI: 10.1016/j.omtm.2018.12.008  0.36
2018 Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP. Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy. Blood Advances. 2: 987-999. PMID 29720491 DOI: 10.1182/bloodadvances.2018016451  0.36
2017 Hale M, Mesojednik T, Romano Ibarra GS, Sahni J, Bernard A, Sommer K, Scharenberg AM, Rawlings DJ, Wagner TA. Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28143740 DOI: 10.1016/j.ymthe.2016.12.023  0.36
2016 Gwiazda KS, Grier AE, Sahni J, Burleigh SM, Martin U, Yang JG, Popp NA, Krutein MC, Khan IF, Jacoby K, Jensen MC, Rawlings DJ, Scharenberg AM. High efficiency CRISPR/Cas9-mediated gene editing in primary human T-cells using mutant adenoviral E4orf6/E1b55k "helper" proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 27203437 DOI: 10.1038/mt.2016.105  0.4
2016 Lambert AR, Hallinan JP, Shen BW, Chik JK, Bolduc JM, Kulshina N, Robins LI, Kaiser BK, Jarjour J, Havens K, Scharenberg AM, Stoddard BL. Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure (London, England : 1993). PMID 27133026 DOI: 10.1016/j.str.2016.03.024  0.4
2016 Grier AE, Burleigh S, Sahni J, Clough CA, Cardot V, Choe DC, Krutein MC, Rawlings DJ, Jensen MC, Scharenberg AM, Jacoby K. pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences. Molecular Therapy. Nucleic Acids. 5: e306. PMID 27093168 DOI: 10.1038/mtna.2016.21  0.36
2016 Hubbard N, Hagin D, Sommer K, Song Y, Khan I, Clough C, Ochs HD, Rawlings DJ, Scharenberg AM, Torgerson TR. Targeted gene editing restores regulated CD40L expression and function in X-HIGM T cells. Blood. PMID 26903548 DOI: 10.1182/blood-2015-11-683235  0.36
2016 Sedlak RH, Liang S, Niyonzima N, De Silva Feelixge HS, Roychoudhury P, Greninger AL, Weber ND, Boissel S, Scharenberg AM, Cheng A, Magaret A, Bumgarner R, Stone D, Jerome KR. Digital detection of endonuclease mediated gene disruption in the HIV provirus. Scientific Reports. 6: 20064. PMID 26829887 DOI: 10.1038/srep20064  0.4
2015 Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J, Jarjour J, Astrakhan A, Wagner TA, Scharenberg AM, Rawlings DJ. Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template. Science Translational Medicine. 7: 307ra156. PMID 26424571 DOI: 10.1126/scitranslmed.aac5530  0.4
2015 Poirot L, Philip B, Schiffer-Mannioui C, Le Clerre D, Chion-Sotinel I, Derniame S, Potrel P, Bas C, Lemaire L, Galetto R, Lebuhotel C, Eyquem J, Cheung GW, Duclert A, Gouble A, ... ... Scharenberg AM, et al. Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies. Cancer Research. 75: 3853-64. PMID 26183927 DOI: 10.1158/0008-5472.CAN-14-3321  0.4
2015 Corrigan-Curay J, O'Reilly M, Kohn DB, Cannon PM, Bao G, Bushman FD, Carroll D, Cathomen T, Joung JK, Roth D, Sadelain M, Scharenberg AM, von Kalle C, Zhang F, Jambou R, et al. Genome editing technologies: defining a path to clinic. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 796-806. PMID 25943494 DOI: 10.1038/mt.2015.54  0.4
2015 Boissel S, Scharenberg AM. Assembly and characterization of megaTALs for hyperspecific genome engineering applications. Methods in Molecular Biology (Clifton, N.J.). 1239: 171-96. PMID 25408406 DOI: 10.1007/978-1-4939-1862-1_9  0.4
2014 Wang Y, Khan IF, Boissel S, Jarjour J, Pangallo J, Thyme S, Baker D, Scharenberg AM, Rawlings DJ. Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus. Nucleic Acids Research. 42: 6463-75. PMID 24682825 DOI: 10.1093/nar/gku224  0.4
2014 Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ, Kiem HP. Intravenous injection of a foamy virus vector to correct canine SCID-X1. Blood. 123: 3578-84. PMID 24642749 DOI: 10.1182/blood-2013-11-538926  0.4
2014 Baxter SK, Scharenberg AM, Lambert AR. Engineering and flow-cytometric analysis of chimeric LAGLIDADG homing endonucleases from homologous I-OnuI-family enzymes. Methods in Molecular Biology (Clifton, N.J.). 1123: 191-221. PMID 24510269 DOI: 10.1007/978-1-62703-968-0_14  0.4
2014 Jacoby K, Scharenberg AM. Homing endonuclease target determination using SELEX adapted for yeast surface display. Methods in Molecular Biology (Clifton, N.J.). 1123: 165-90. PMID 24510268 DOI: 10.1007/978-1-62703-968-0_13  0.4
2014 Aubert M, Boyle NM, Stone D, Stensland L, Huang ML, Magaret AS, Galetto R, Rawlings DJ, Scharenberg AM, Jerome KR. In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease. Molecular Therapy. Nucleic Acids. 3: e146. PMID 24496438 DOI: 10.1038/mtna.2013.75  0.4
2014 Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM. MegaTALs: A rare-cleaving nuclease architecture for therapeutic genome engineering Nucleic Acids Research. 42: 2591-2601. PMID 24285304 DOI: 10.1093/nar/gkt1224  0.4
2014 Kuhar R, Gwiazda KS, Humbert O, Mandt T, Pangallo J, Brault M, Khan I, Maizels N, Rawlings DJ, Scharenberg AM, Certo MT. Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks. Nucleic Acids Research. 42: e4. PMID 24121685 DOI: 10.1093/nar/gkt872  0.4
2013 Scharenberg AM, Duchateau P, Smith J. Genome engineering with TAL-effector nucleases and alternative modular nuclease technologies Current Gene Therapy. 13: 291-303. PMID 23888878 DOI: 10.2174/15665232113139990026  0.4
2013 Baxter SK, Lambert AR, Scharenberg AM, Jarjour J. Flow cytometric assays for interrogating LAGLIDADG homing endonuclease DNA-binding and cleavage properties. Methods in Molecular Biology (Clifton, N.J.). 978: 45-61. PMID 23423888 DOI: 10.1007/978-1-62703-293-3_4  0.4
2012 Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, ... Scharenberg AM, et al. Coupling endonucleases with DNA end-processing enzymes to drive gene disruption. Nature Methods. 9: 973-5. PMID 22941364 DOI: 10.1038/nmeth.2177  0.4
2012 Baxter S, Lambert AR, Kuhar R, Jarjour J, Kulshina N, Parmeggiani F, Danaher P, Gano J, Baker D, Stoddard BL, Scharenberg AM. Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases. Nucleic Acids Research. 40: 7985-8000. PMID 22684507 DOI: 10.1093/nar/gks502  0.4
2012 Ramirez CL, Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK. Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Research. 40: 5560-8. PMID 22373919 DOI: 10.1093/nar/gks179  0.4
2012 Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM. Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space. Nucleic Acids Research. 40: 4954-64. PMID 22334611 DOI: 10.1093/nar/gkr1303  0.4
2012 Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP. Novel reporter systems for facile evaluation of I-SceI-mediated genome editing. Nucleic Acids Research. 40: e14. PMID 22110042 DOI: 10.1093/nar/gkr897  0.4
2011 Takeuchi R, Lambert AR, Mak AN, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL. Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proceedings of the National Academy of Sciences of the United States of America. 108: 13077-82. PMID 21784983 DOI: 10.1073/pnas.1107719108  0.4
2011 Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM. Tracking genome engineering outcome at individual DNA breakpoints. Nature Methods. 8: 671-6. PMID 21743461 DOI: 10.1038/nmeth.1648  0.4
2011 Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR. Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI. Plos One. 6: e16825. PMID 21399673 DOI: 10.1371/journal.pone.0016825  0.4
2010 Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE. Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. The Journal of Allergy and Clinical Immunology. 126: 1000-5. PMID 20643476 DOI: 10.1016/j.jaci.2010.05.021  0.4
2009 Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D. Exploitation of binding energy for catalysis and design. Nature. 461: 1300-4. PMID 19865174 DOI: 10.1038/nature08508  0.4
2009 Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM. High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display. Nucleic Acids Research. 37: 6871-80. PMID 19740766 DOI: 10.1093/nar/gkp726  0.4
2009 Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL. Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Research. 37: 877-90. PMID 19103658 DOI: 10.1093/nar/gkn1007  0.4
2009 Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM. Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient. Clinical Immunology (Orlando, Fla.). 130: 162-74. PMID 18952502 DOI: 10.1016/j.clim.2008.08.026  0.4
2007 Scharenberg AM, Humphries LA, Rawlings DJ. Calcium signalling and cell-fate choice in B cells. Nature Reviews. Immunology. 7: 778-89. PMID 17853903 DOI: 10.1038/nri2172  0.4
2007 Volná P, Jarjour J, Baxter S, Roffler SR, Monnat RJ, Stoddard BL, Scharenberg AM. Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases. Nucleic Acids Research. 35: 2748-58. PMID 17426121 DOI: 10.1093/nar/gkm182  0.4
2006 Grubisha O, Rafty LA, Takanishi CL, Xu X, Tong L, Perraud AL, Scharenberg AM, Denu JM. Metabolite of SIR2 reaction modulates TRPM2 ion channel. The Journal of Biological Chemistry. 281: 14057-65. PMID 16565078 DOI: 10.1074/jbc.M513741200  0.4
2005 Perraud AL, Takanishi CL, Shen B, Kang S, Smith MK, Schmitz C, Knowles HM, Ferraris D, Li W, Zhang J, Stoddard BL, Scharenberg AM. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. The Journal of Biological Chemistry. 280: 6138-48. PMID 15561722 DOI: 10.1074/jbc.M411446200  0.4
2004 Takezawa R, Schmitz C, Demeuse P, Scharenberg AM, Penner R, Fleig A. Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proceedings of the National Academy of Sciences of the United States of America. 101: 6009-14. PMID 15069188 DOI: 10.1073/pnas.0307565101  0.4
2004 Schmitz C, Perraud AL, Fleig A, Scharenberg AM. Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms. Pediatric Research. 55: 734-7. PMID 14764909 DOI: 10.1203/01.PDR.0000117848.37520.A2  0.4
2003 Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL. BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity. 19: 669-78. PMID 14614854 DOI: 10.1016/S1074-7613(03)00297-8  0.4
2003 Shen BW, Perraud AL, Scharenberg A, Stoddard BL. The crystal structure and mutational analysis of human NUDT9. Journal of Molecular Biology. 332: 385-98. PMID 12948489 DOI: 10.1016/S0022-2836(03)00954-9  0.4
2003 Schmitz C, Perraud AL, Johnson CO, Inabe K, Smith MK, Penner R, Kurosaki T, Fleig A, Scharenberg AM. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell. 114: 191-200. PMID 12887921 DOI: 10.1016/S0092-8674(03)00556-7  0.4
2003 Monteilh-Zoller MK, Hermosura MC, Nadler MJ, Scharenberg AM, Penner R, Fleig A. TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. The Journal of General Physiology. 121: 49-60. PMID 12508053 DOI: 10.1085/jgp.20028740  0.4
2003 Matthews SA, Dayalu R, Thompson LJ, Scharenberg AM. Regulation of protein kinase Cnu by the B-cell antigen receptor. The Journal of Biological Chemistry. 278: 9086-91. PMID 12506120 DOI: 10.1074/jbc.M211295200  0.4
2003 Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. The Journal of Biological Chemistry. 278: 1794-801. PMID 12427752 DOI: 10.1074/jbc.M205601200  0.4
2002 Rafty LA, Schmidt MT, Perraud AL, Scharenberg AM, Denu JM. Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases. The Journal of Biological Chemistry. 277: 47114-22. PMID 12370179 DOI: 10.1074/jbc.M208997200  0.4
2002 Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP. TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell. 109: 397-407. PMID 12015988 DOI: 10.1016/S0092-8674(02)00719-5  0.4
2002 Hermosura MC, Monteilh-Zoller MK, Scharenberg AM, Penner R, Fleig A. Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM. The Journal of Physiology. 539: 445-58. PMID 11882677 DOI: 10.1113/jphysiol.2001.013361  0.4
2002 Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, et al. A unified nomenclature for the superfamily of TRP cation channels. Molecular Cell. 9: 229-31. PMID 11864597 DOI: 10.1016/S1097-2765(02)00448-3  0.4
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