Navdeep S. Chandel - Publications

Affiliations: 
Integrated Graduate Program in the Life Sciences Northwestern University, Evanston, IL 
Area:
Cell Biology, Biochemistry, Medicine and Surgery

129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Fu Z, Ye J, Dean JW, Bostick JW, Weinberg SE, Xiong L, Oliff KN, Chen ZE, Avram D, Chandel NS, Zhou L. Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function. Cell Reports. 28: 159-171.e4. PMID 31269437 DOI: 10.1016/j.celrep.2019.06.024  0.64
2019 Diebold LP, Gil HJ, Gao P, Martinez CA, Weinberg SE, Chandel NS. Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis. Nature Metabolism. 1: 158-171. PMID 31106291 DOI: 10.1038/s42255-018-0011-x  0.64
2019 Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS. Serine Metabolism Supports Macrophage IL-1β Production. Cell Metabolism. PMID 30773464 DOI: 10.1016/j.cmet.2019.01.014  0.64
2019 Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, ... ... Chandel NS, et al. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metabolism. 29: 503. PMID 30726761 DOI: 10.1016/j.cmet.2018.12.001  0.36
2019 Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Martínez-Reyes I, Gao P, Helmin KA, Abdala-Valencia H, Sena LA, Schumacker PT, Turka LA, Chandel NS. Mitochondrial complex III is essential for suppressive function of regulatory T cells. Nature. PMID 30626970 DOI: 10.1038/s41586-018-0846-z  0.84
2019 May JL, Kouri FM, Hurley LA, Liu J, Tommasini-Ghelfi S, Ji Y, Gao P, Calvert AE, Lee A, Chandel NS, Davuluri RV, Horbinski CM, Locasale JW, Stegh AH. IDH3α regulates one-carbon metabolism in glioblastoma. Science Advances. 5: eaat0456. PMID 30613765 DOI: 10.1126/sciadv.aat0456  0.52
2018 Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Charvet LY, Chandel NS, Schumacker PT, Thorp EB. Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair. Cell Metabolism. PMID 30595481 DOI: 10.1016/j.cmet.2018.12.004  0.32
2018 Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Adbala-Valencia H, ... ... Chandel NS, et al. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metabolism. PMID 30318339 DOI: 10.1016/j.cmet.2018.09.019  0.36
2018 Mehta MM, Weinberg SE, Steinert EM, Chhiba K, Martinez CA, Gao P, Perlman HR, Bryce P, Hay N, Chandel NS. Hexokinase 2 is dispensable for T cell-dependent immunity. Cancer & Metabolism. 6: 10. PMID 30140438 DOI: 10.1186/s40170-018-0184-5  0.64
2017 Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J. JNK2 Upregulates Hypoxia-Inducible Factors and Contributes to Hypoxia-Induced Erythropoiesis and Pulmonary Hypertension. The Journal of Biological Chemistry. PMID 29118187 DOI: 10.1074/jbc.RA117.000440  0.52
2017 Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, ... ... Chandel NS, et al. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. The Journal of Experimental Medicine. PMID 28694385 DOI: 10.1084/jem.20162152  0.36
2017 Mehta MM, Weinberg SE, Chandel NS. Mitochondrial control of immunity: beyond ATP. Nature Reviews. Immunology. PMID 28669986 DOI: 10.1038/nri.2017.66  0.64
2017 Calvert AE, Chalastanis A, Wu Y, Hurley LA, Kouri FM, Bi Y, Kachman M, May JL, Bartom E, Hua Y, Mishra RK, Schiltz GE, Dubrovskyi O, Mazar AP, Peter ME, ... ... Chandel NS, et al. Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation. Cell Reports. 19: 1858-1873. PMID 28564604 DOI: 10.1016/j.celrep.2017.05.014  0.52
2017 Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, et al. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nature Cell Biology. PMID 28504707 DOI: 10.1038/ncb3527  0.64
2017 Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS. The mitochondrial respiratory chain is essential for haematopoietic stem cell function. Nature Cell Biology. PMID 28504706 DOI: 10.1038/ncb3529  0.64
2017 Ceco E, Weinberg SE, Chandel NS, Sznajder JI. Metabolism and Skeletal Muscle Homeostasis in Lung Disease. American Journal of Respiratory Cell and Molecular Biology. PMID 28085493 DOI: 10.1165/rcmb.2016-0355TR  0.64
2016 Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM. TGF-β Promotes de novo Serine Synthesis for Collagen Production. The Journal of Biological Chemistry. PMID 27836973 DOI: 10.1074/jbc.M116.756247  0.36
2016 Chandel NS, Avizonis D, Reczek CR, Weinberg SE, Menz S, Neuhaus R, Christian S, Haegebarth A, Algire C, Pollak M. Are Metformin Doses Used in Murine Cancer Models Clinically Relevant? Cell Metabolism. 23: 569-70. PMID 27076070 DOI: 10.1016/j.cmet.2016.03.010  0.64
2016 Hamanaka RB, Weinberg SE, Reczek CR, Chandel NS. The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia. Cell Reports. PMID 27068470 DOI: 10.1016/j.celrep.2016.03.044  0.64
2016 Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P. Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in Giant Axonal Neuropathy. Human Molecular Genetics. PMID 27000625 DOI: 10.1093/hmg/ddw081  0.32
2016 Diebold LP, Chandel NS. HSC Fate Is Tethered to Mitochondria. Cell Stem Cell. 18: 303-4. PMID 26942848 DOI: 10.1016/j.stem.2016.02.007  0.52
2015 Martínez-Reyes I, Diebold LP, Kong H, Schieber M, Huang H, Hensley CT, Mehta MM, Wang T, Santos JH, Woychik R, Dufour E, Spelbrink JN, Weinberg SE, Zhao Y, DeBerardinis RJ, ... Chandel NS, et al. TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. Molecular Cell. PMID 26725009 DOI: 10.1016/j.molcel.2015.12.002  0.84
2015 Zhang Q, Kuang H, Chen C, Yan J, Do-Umehara HC, Liu XY, Dada L, Ridge KM, Chandel NS, Liu J. Corrigendum: The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nature Immunology. 16: 785. PMID 26086147 DOI: 10.1038/ni0715-785b  0.84
2015 Zhang Q, Kuang H, Chen C, Yan J, Do-Umehara HC, Liu XY, Dada L, Ridge KM, Chandel NS, Liu J. The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nature Immunology. 16: 458-66. PMID 25799126 DOI: 10.1038/ni.3130  0.84
2015 Weinberg SE, Sena LA, Chandel NS. Mitochondria in the regulation of innate and adaptive immunity. Immunity. 42: 406-17. PMID 25786173 DOI: 10.1016/j.immuni.2015.02.002  0.84
2015 Mehta MM, Chandel NS. Targeting metabolism for lupus therapy. Science Translational Medicine. 7: 274fs5. PMID 25673759 DOI: 10.1126/scitranslmed.aaa6731  0.84
2015 Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, Selman M, Pardo A, White ES, Levy BD, Busse PJ, Tuder RM, Antony VB, Sznajder JI, Budinger GR. Blue journal conference. Aging and susceptibility to lung disease. American Journal of Respiratory and Critical Care Medicine. 191: 261-9. PMID 25590812 DOI: 10.1164/rccm.201410-1876PP  0.84
2015 Weinberg SE, Chandel NS. Targeting mitochondria metabolism for cancer therapy. Nature Chemical Biology. 11: 9-15. PMID 25517383 DOI: 10.1038/nchembio.1712  0.84
2014 Sullivan LB, Chandel NS. Mitochondrial reactive oxygen species and cancer. Cancer & Metabolism. 2: 17. PMID 25671107 DOI: 10.1186/2049-3002-2-17  0.72
2014 Schieber M, Chandel NS. TOR signaling couples oxygen sensing to lifespan in C. elegans. Cell Reports. 9: 9-15. PMID 25284791 DOI: 10.1016/j.celrep.2014.08.075  0.48
2014 Morales-Nebreda L, Chi M, Lecuona E, Chandel NS, Dada LA, Ridge K, Soberanes S, Nigdelioglu R, Sznajder JI, Mutlu GM, Budinger GRS, Radigan KA. Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury Journal of Virological Methods. 209: 116-120. PMID 25239366 DOI: 10.1016/j.jviromet.2014.09.004  0.84
2014 Queisser MA, Dada LA, Deiss-Yehiely N, Angulo M, Zhou G, Kouri FM, Knab LM, Liu J, Stegh AH, DeCamp MM, Budinger GR, Chandel NS, Ciechanover A, Iwai K, Sznajder JI. HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth. American Journal of Respiratory and Critical Care Medicine. 190: 688-98. PMID 25118570 DOI: 10.1164/rccm.201403-0463OC  0.84
2014 Glasauer A, Chandel NS. Targeting antioxidants for cancer therapy. Biochemical Pharmacology. 92: 90-101. PMID 25078786 DOI: 10.1016/j.bcp.2014.07.017  0.96
2014 Weinberg SE, Chandel NS. Futility sustains memory T cells. Immunity. 41: 1-3. PMID 25035944 DOI: 10.1016/j.immuni.2014.06.009  0.84
2014 Chandel NS, Tuveson DA. The promise and perils of antioxidants for cancer patients. The New England Journal of Medicine. 371: 177-8. PMID 25006725 DOI: 10.1056/NEJMcibr1405701  0.84
2014 Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, ... Chandel NS, et al. β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. The Journal of Clinical Investigation. 124: 2935-46. PMID 24865431 DOI: 10.1172/JCI75157  0.36
2014 Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Reports. 7: 1679-90. PMID 24857658 DOI: 10.1016/j.celrep.2014.04.037  0.72
2014 Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Current Biology : Cb. 24: R453-62. PMID 24845678 DOI: 10.1016/j.cub.2014.03.034  0.48
2014 Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife. 3: e02242. PMID 24843020 DOI: 10.7554/eLife.02242  0.84
2014 Sullivan LB, Chandel NS. Mitochondrial metabolism in TCA cycle mutant cancer cells. Cell Cycle (Georgetown, Tex.). 13: 347-8. PMID 24335489 DOI: 10.4161/cc.27513  0.72
2014 Glasauer A, Sena LA, Diebold LP, Mazar AP, Chandel NS. Targeting SOD1 reduces experimental non–small-cell lung cancer. The Journal of Clinical Investigation. 124: 117-28. PMID 24292713 DOI: 10.1172/JCI71714  0.84
2013 Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, ... Chandel NS, et al. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (New York, N.Y.). 342: 1243417. PMID 24051248 DOI: 10.1126/science.1243417  0.84
2013 Nguyen HP, Chandel NS, DeBerardinis RJ, Schug KA. Hydrophilic interaction liquid chromatography coupled with MS/MS to detect and quantify dicarboxyethyl glutathione, a metabolic biomarker of the fumarate hydratase deficient cancer cell. Journal of Separation Science. 36: 3303-9. PMID 23963958 DOI: 10.1002/jssc.201300602  0.84
2013 Kamp DW, Liu G, Cheresh P, Kim SJ, Mueller A, Lam AP, Trejo H, Williams D, Tulasiram S, Baker M, Ridge K, Chandel NS, Beri R. Asbestos-induced alveolar epithelial cell apoptosis: The role of endoplasmic reticulum stress response American Journal of Respiratory Cell and Molecular Biology. 49: 892-901. PMID 23885834 DOI: 10.1165/rcmb.2013-0053OC  0.84
2013 Chandel NS, Budinger GR. The good and the bad of antibiotics. Science Translational Medicine. 5: 192fs25. PMID 23825300 DOI: 10.1126/scitranslmed.3006567  0.32
2013 Sullivan LB, Martinez-Garcia E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, Licht JD, Deberardinis RJ, Chandel NS. The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Molecular Cell. 51: 236-48. PMID 23747014 DOI: 10.1016/j.molcel.2013.05.003  0.72
2013 Schieber MS, Chandel NS. ROS links glucose metabolism to breast cancer stem cell and EMT phenotype. Cancer Cell. 23: 265-7. PMID 23518342 DOI: 10.1016/j.ccr.2013.02.021  1
2013 Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity. 38: 225-36. PMID 23415911 DOI: 10.1016/j.immuni.2012.10.020  0.84
2013 Glasauer A, Chandel NS. ROS. Current Biology : Cb. 23: R100-2. PMID 23391379 DOI: 10.1016/j.cub.2012.12.011  0.96
2013 Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS. Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Science Signaling. 6: ra8. PMID 23386745 DOI: 10.1126/scisignal.2003638  0.84
2013 Jain M, Rivera S, Monclus EA, Synenki L, Zirk A, Eisenbart J, Feghali-Bostwick C, Mutlu GM, Budinger GR, Chandel NS. Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling. The Journal of Biological Chemistry. 288: 770-7. PMID 23204521 DOI: 10.1074/jbc.M112.431973  0.84
2012 Sena LA, Chandel NS. Physiological roles of mitochondrial reactive oxygen species. Molecular Cell. 48: 158-67. PMID 23102266 DOI: 10.1016/j.molcel.2012.09.025  0.84
2012 Sullivan LB, Santos JH, Chandel NS. Mitochondria and telomeres: the promiscuous roles of TIN2. Molecular Cell. 47: 823-4. PMID 23020852 DOI: 10.1016/j.molcel.2012.09.006  0.72
2012 Peng H, Kaplan N, Hamanaka RB, Katsnelson J, Blatt H, Yang W, Hao L, Bryar PJ, Johnson RS, Getsios S, Chandel NS, Lavker RM. microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America. 109: 14030-4. PMID 22891326 DOI: 10.1073/pnas.1111292109  0.84
2012 Peng H, Hamanaka RB, Katsnelson J, Hao LL, Yang W, Chandel NS, Lavker RM. MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3140-7. PMID 22532441 DOI: 10.1096/fj.11-198515  0.84
2012 Soberanes S, Gonzalez A, Urich D, Chiarella SE, Radigan KA, Osornio-Vargas A, Joseph J, Kalyanaraman B, Ridge KM, Chandel NS, Mutlu GM, De Vizcaya-Ruiz A, Budinger GR. Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. Scientific Reports. 2: 275. PMID 22355787 DOI: 10.1038/srep00275  0.84
2012 Hamanaka RB, Chandel NS. Targeting glucose metabolism for cancer therapy. The Journal of Experimental Medicine. 209: 211-5. PMID 22330683 DOI: 10.1084/jem.20120162  0.84
2012 Dada L, Gonzalez AR, Urich D, Soberanes S, Manghi TS, Chiarella SE, Chandel NS, Budinger GR, Mutlu GM. Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor. Plos One. 7: e30448. PMID 22272351 DOI: 10.1371/journal.pone.0030448  0.84
2012 Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 481: 385-8. PMID 22101431 DOI: 10.1038/nature10642  0.84
2012 Woo DK, Green PD, Santos JH, D'Souza AD, Walther Z, Martin WD, Christian BE, Chandel NS, Shadel GS. Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. The American Journal of Pathology. 180: 24-31. PMID 22056359 DOI: 10.1016/j.ajpath.2011.10.003  0.84
2012 Mutlu GM, Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, et al. Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling. Thorax. 67: 139-46. PMID 21921091 DOI: 10.1136/thoraxjnl-2011-200717  0.84
2011 Shimi T, Butin-Israeli V, Adam SA, Hamanaka RB, Goldman AE, Lucas CA, Shumaker DK, Kosak ST, Chandel NS, Goldman RD. The role of nuclear lamin B1 in cell proliferation and senescence. Genes & Development. 25: 2579-93. PMID 22155925 DOI: 10.1101/gad.179515.111  0.84
2011 Tormos KV, Chandel NS. Seeing the light: probing ROS in vivo using redox GFP. Cell Metabolism. 14: 720-1. PMID 22152299 DOI: 10.1016/j.cmet.2011.11.008  0.68
2011 Hamanaka RB, Chandel NS. Cell biology. Warburg effect and redox balance. Science (New York, N.Y.). 334: 1219-20. PMID 22144609 DOI: 10.1126/science.1215637  0.84
2011 Duch MC, Budinger GR, Liang YT, Soberanes S, Urich D, Chiarella SE, Campochiaro LA, Gonzalez A, Chandel NS, Hersam MC, Mutlu GM. Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. Nano Letters. 11: 5201-7. PMID 22023654 DOI: 10.1021/nl202515a  0.84
2011 Tormos KV, Anso E, Hamanaka RB, Eisenbart J, Joseph J, Kalyanaraman B, Chandel NS. Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metabolism. 14: 537-44. PMID 21982713 DOI: 10.1016/j.cmet.2011.08.007  0.84
2011 Mauro C, Leow SC, Anso E, Rocha S, Thotakura AK, Tornatore L, Moretti M, De Smaele E, Beg AA, Tergaonkar V, Chandel NS, Franzoso G. NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nature Cell Biology. 13: 1272-9. PMID 21968997 DOI: 10.1038/ncb2324  0.84
2011 Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI. Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Molecular and Cellular Biology. 31: 3546-56. PMID 21730292 DOI: 10.1128/MCB.05114-11  0.84
2011 Dirisina R, Katzman RB, Goretsky T, Managlia E, Mittal N, Williams DB, Qiu W, Yu J, Chandel NS, Zhang L, Barrett TA. p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology. 141: 1036-45. PMID 21699775 DOI: 10.1053/j.gastro.2011.05.032  0.84
2011 Jain M, Budinger GR, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM. Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ. American Journal of Respiratory and Critical Care Medicine. 183: 1490-8. PMID 21317313 DOI: 10.1164/rccm.201009-1409OC  0.84
2011 Loor G, Kondapalli J, Iwase H, Chandel NS, Waypa GB, Guzy RD, Vanden Hoek TL, Schumacker PT. Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochimica Et Biophysica Acta. 1813: 1382-94. PMID 21185334 DOI: 10.1016/j.bbamcr.2010.12.008  0.32
2011 Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, ... ... Chandel NS, et al. Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. American Journal of Respiratory and Critical Care Medicine. 183: 1043-54. PMID 20959557 DOI: 10.1164/rccm.201002-0181OC  0.36
2010 Loor G, Kondapalli J, Schriewer JM, Chandel NS, Vanden Hoek TL, Schumacker PT. Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis. Free Radical Biology & Medicine. 49: 1925-36. PMID 20937380 DOI: 10.1016/j.freeradbiomed.2010.09.021  0.84
2010 Hamanaka RB, Chandel NS. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends in Biochemical Sciences. 35: 505-13. PMID 20430626 DOI: 10.1016/j.tibs.2010.04.002  0.84
2010 Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proceedings of the National Academy of Sciences of the United States of America. 107: 8788-93. PMID 20421486 DOI: 10.1073/pnas.1003428107  0.84
2010 Tormos KV, Chandel NS. Inter-connection between mitochondria and HIFs. Journal of Cellular and Molecular Medicine. 14: 795-804. PMID 20158574 DOI: 10.1111/j.1582-4934.2010.01031.x  0.68
2010 Scatizzi JC, Hutcheson J, Pope RM, Firestein GS, Koch AE, Mavers M, Smason A, Agrawal H, Haines GK, Chandel NS, Hotchkiss RS, Perlman H. Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis and Rheumatism. 62: 441-51. PMID 20112357 DOI: 10.1002/art.27198  0.84
2010 Na N, Chandel NS, Litvan J, Ridge KM. Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 799-809. PMID 19897662 DOI: 10.1096/fj.08-128967  0.84
2009 Hamanaka RB, Chandel NS. Mitochondrial reactive oxygen species regulate hypoxic signaling. Current Opinion in Cell Biology. 21: 894-9. PMID 19781926 DOI: 10.1016/j.ceb.2009.08.005  0.84
2009 Snyder CM, Shroff EH, Liu J, Chandel NS. Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members. Plos One. 4: e7059. PMID 19768117 DOI: 10.1371/journal.pone.0007059  0.96
2009 Snyder CM, Chandel NS. Mitochondrial regulation of cell survival and death during low-oxygen conditions. Antioxidants & Redox Signaling. 11: 2673-83. PMID 19580395 DOI: 10.1089/ars.2009.2730  0.96
2009 Shroff EH, Snyder CM, Budinger GR, Jain M, Chew TL, Khuon S, Perlman H, Chandel NS. BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK. Plos One. 4: e5646. PMID 19468307 DOI: 10.1371/journal.pone.0005646  0.96
2009 Chandel NS, Budinger GR, Mutlu GM, Varga J, Synenki L, Donnelly HK, Zirk A, Eisenbart J, Jovanovic B, Jain M. Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways. Critical Care Medicine. 37: 1678-84. PMID 19325470 DOI: 10.1097/CCM.0b013e31819fc81a  0.84
2009 Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budinger GR, Chandel NS. Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Radical Biology & Medicine. 46: 1386-91. PMID 19268526 DOI: 10.1016/j.freeradbiomed.2009.02.019  0.84
2009 Urich D, Soberanes S, Burgess Z, Chiarella SE, Ghio AJ, Ridge KM, Kamp DW, Chandel NS, Mutlu GM, Budinger GRS. Proapoptotic Noxa is required for particulate matterinduced cell death and lung inflammation Faseb Journal. 23: 2055-2064. PMID 19237507 DOI: 10.1096/fj.08-114546  0.84
2009 Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR. Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. The Journal of Biological Chemistry. 284: 2176-86. PMID 19033436 DOI: 10.1074/jbc.M808844200  0.84
2009 Klimova TA, Bell EL, Shroff EH, Weinberg FD, Snyder CM, Dimri GP, Schumacker PT, Budinger GR, Chandel NS. Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 783-94. PMID 18948382 DOI: 10.1096/fj.08-114256  0.96
2008 Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS. PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proceedings of the National Academy of Sciences of the United States of America. 105: 2622-7. PMID 18268343 DOI: 10.1073/pnas.0706790105  0.84
2008 Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI. AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis. The Journal of Clinical Investigation. 118: 752-62. PMID 18188452 DOI: 10.1172/JCI29723  0.84
2008 Lin X, David CA, Donnelly JB, Michaelides M, Chandel NS, Huang X, Warrior U, Weinberg F, Tormos KV, Fesik SW, Shen Y. A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation. Proceedings of the National Academy of Sciences of the United States of America. 105: 174-9. PMID 18172210 DOI: 10.1073/pnas.0706585104  0.68
2008 Zhou G, Dada LA, Chandel NS, Iwai K, Lecuona E, Ciechanover A, Sznajder JI. Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1335-42. PMID 18073334 DOI: 10.1096/fj.07-8369com  0.84
2008 Bell EL, Klimova T, Chandel NS. Targeting the mitochondria for cancer therapy: regulation of hypoxia-inducible factor by mitochondria. Antioxidants & Redox Signaling. 10: 635-40. PMID 17999628 DOI: 10.1089/ars.2007.1655  0.48
2008 Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT. Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Molecular and Cellular Biology. 28: 718-31. PMID 17967865 DOI: 10.1128/MCB.01338-07  0.32
2007 Emerling BM, Viollet B, Tormos KV, Chandel NS. Compound C inhibits hypoxic activation of HIF-1 independent of AMPK. Febs Letters. 581: 5727-31. PMID 18036344 DOI: 10.1016/j.febslet.2007.11.038  0.84
2007 Bell EL, Chandel NS. Genetics of mitochondrial electron transport chain in regulating oxygen sensing. Methods in Enzymology. 435: 447-61. PMID 17998068 DOI: 10.1016/S0076-6879(07)35023-4  0.48
2007 Mutlu GM, Green D, Bellmeyer A, Baker CM, Burgess Z, Rajamannan N, Christman JW, Foiles N, Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GR. Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. The Journal of Clinical Investigation. 117: 2952-61. PMID 17885684 DOI: 10.1172/JCI30639  0.84
2007 Bell EL, Chandel NS. Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species. Essays in Biochemistry. 43: 17-27. PMID 17705790 DOI: 10.1042/BSE0430017  0.48
2007 Wang HL, Akinci IO, Baker CM, Urich D, Bellmeyer A, Jain M, Chandel NS, Mutlu GM, Budinger GR. The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death. Journal of Immunology (Baltimore, Md. : 1950). 179: 1834-41. PMID 17641050  0.84
2007 Iwase H, Robin E, Guzy RD, Mungai PT, Vanden Hoek TL, Chandel NS, Levraut J, Schumacker PT. Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes. Free Radical Biology & Medicine. 43: 590-9. PMID 17640569 DOI: 10.1016/j.freeradbiomed.2007.05.017  0.84
2007 Shroff EH, Snyder C, Chandel NS. Bcl-2 family members regulate anoxia-induced cell death. Antioxidants & Redox Signaling. 9: 1405-9. PMID 17627475 DOI: 10.1089/ars.2007.1731  0.52
2007 Bell EL, Klimova TA, Eisenbart J, Schumacker PT, Chandel NS. Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia. Molecular and Cellular Biology. 27: 5737-45. PMID 17562866 DOI: 10.1128/MCB.02265-06  0.48
2007 Bell EL, Klimova TA, Eisenbart J, Moraes CT, Murphy MP, Budinger GR, Chandel NS. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. The Journal of Cell Biology. 177: 1029-36. PMID 17562787 DOI: 10.1083/jcb.200609074  0.84
2007 Shroff EH, Snyder C, Chandel NS. Role of Bcl-2 family members in anoxia induced cell death. Cell Cycle (Georgetown, Tex.). 6: 807-9. PMID 17377500 DOI: 10.4161/cc.6.7.4044  0.52
2007 Synenki L, Chandel NS, Budinger GR, Donnelly HK, Topin J, Eisenbart J, Jovanovic B, Jain M. Bronchoalveolar lavage fluid from patients with acute lung injury/acute respiratory distress syndrome induces myofibroblast differentiation. Critical Care Medicine. 35: 842-8. PMID 17255860 DOI: 10.1097/01.CCM.0000257254.87984.69  0.32
2007 Chandel NS, Budinger GR. The cellular basis for diverse responses to oxygen. Free Radical Biology & Medicine. 42: 165-74. PMID 17189822 DOI: 10.1016/j.freeradbiomed.2006.10.048  0.32
2007 Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM. Leptin resistance protects mice from hyperoxia-induced acute lung injury. American Journal of Respiratory and Critical Care Medicine. 175: 587-94. PMID 17185651 DOI: 10.1164/rccm.200603-312OC  0.84
2007 Brunelle JK, Shroff EH, Perlman H, Strasser A, Moraes CT, Flavell RA, Danial NN, Keith B, Thompson CB, Chandel NS. Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death. Molecular and Cellular Biology. 27: 1222-35. PMID 17145774 DOI: 10.1128/MCB.01535-06  0.84
2006 Comellas AP, Dada LA, Lecuona E, Pesce LM, Chandel NS, Quesada N, Budinger GR, Strous GJ, Ciechanover A, Sznajder JI. Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Circulation Research. 98: 1314-22. PMID 16614303 DOI: 10.1161/01.RES.0000222418.99976.1d  0.84
2006 Budinger GR, Mutlu GM, Eisenbart J, Fuller AC, Bellmeyer AA, Baker CM, Wilson M, Ridge K, Barrett TA, Lee VY, Chandel NS. Proapoptotic Bid is required for pulmonary fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 4604-9. PMID 16537427 DOI: 10.1073/pnas.0507604103  0.84
2006 Mutlu GM, Snyder C, Bellmeyer A, Wang H, Hawkins K, Soberanes S, Welch LC, Ghio AJ, Chandel NS, Kamp D, Sznajder JI, Budinger GR. Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation. American Journal of Respiratory Cell and Molecular Biology. 34: 670-6. PMID 16439801 DOI: 10.1165/rcmb.2005-0329OC  0.84
2005 Lewis JS, Meeke K, Osipo C, Ross EA, Kidawi N, Li T, Bell E, Chandel NS, Jordan VC. Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. Journal of the National Cancer Institute. 97: 1746-59. PMID 16333030 DOI: 10.1093/jnci/dji400  0.84
2005 Lee VY, Schroedl C, Brunelle JK, Buccellato LJ, Akinci OI, Kaneto H, Snyder C, Eisenbart J, Budinger GR, Chandel NS. Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway. American Journal of Physiology. Lung Cellular and Molecular Physiology. 289: L521-8. PMID 16148050 DOI: 10.1152/ajplung.00340.2004  0.84
2005 Bell EL, Emerling BM, Chandel NS. Mitochondrial regulation of oxygen sensing. Mitochondrion. 5: 322-32. PMID 16146708 DOI: 10.1016/j.mito.2005.06.005  0.84
2005 Brunelle JK, Bell EL, Quesada NM, Vercauteren K, Tiranti V, Zeviani M, Scarpulla RC, Chandel NS. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metabolism. 1: 409-14. PMID 16054090 DOI: 10.1016/j.cmet.2005.05.002  0.84
2005 Emerling BM, Chandel NS. Oxygen sensing: getting pumped by sterols. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe30. PMID 15972699 DOI: 10.1126/stke.2892005pe30  0.84
2005 Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS. Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Molecular and Cellular Biology. 25: 4853-62. PMID 15923604 DOI: 10.1128/MCB.25.12.4853-4862.2005  0.84
2005 Budinger GR, Chandel NS, Donnelly HK, Eisenbart J, Oberoi M, Jain M. Active transforming growth factor-beta1 activates the procollagen I promoter in patients with acute lung injury. Intensive Care Medicine. 31: 121-8. PMID 15565360 DOI: 10.1007/s00134-004-2503-2  0.32
2004 DeHahn KC, Gonzales M, Gonzalez AM, Hopkinson SB, Chandel NS, Brunelle JK, Jones JC. The alpha4 laminin subunit regulates endothelial cell survival. Experimental Cell Research. 294: 281-9. PMID 14980521 DOI: 10.1016/j.yexcr.2003.11.006  0.84
2004 Brunelle JK, Santore MT, Budinger GR, Tang Y, Barrett TA, Zong WX, Kandel E, Keith B, Simon MC, Thompson CB, Hay N, Chandel NS. c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1. The Journal of Biological Chemistry. 279: 4305-12. PMID 14627695 DOI: 10.1074/jbc.M312241200  0.84
2004 Buccellato LJ, Tso M, Akinci OI, Chandel NS, Budinger GR. Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells. The Journal of Biological Chemistry. 279: 6753-60. PMID 14625274 DOI: 10.1074/jbc.M310145200  0.84
2003 Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI. Hypoxia-induced endocytosis, of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ Journal of Clinical Investigation. 111: 1057-1064. PMID 12671055 DOI: 10.1172/JCI200316826  0.84
2002 Schroedl C, McClintock DS, Budinger GR, Chandel NS. Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. American Journal of Physiology. Lung Cellular and Molecular Physiology. 283: L922-31. PMID 12376345 DOI: 10.1152/ajplung.00014.2002  0.32
2002 Brunelle JK, Chandel NS. Oxygen deprivation induced cell death: an update. Apoptosis : An International Journal On Programmed Cell Death. 7: 475-82. PMID 12370489  0.92
2002 Kulisz A, Chen N, Chandel NS, Shao Z, Schumacker PT. Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L1324-9. PMID 12003789 DOI: 10.1152/ajplung.00326.2001  0.32
2002 Santore MT, McClintock DS, Lee VY, Budinger GR, Chandel NS. Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L727-34. PMID 11880298 DOI: 10.1152/ajplung.00281.2001  0.32
2002 Budinger GR, Tso M, McClintock DS, Dean DA, Sznajder JI, Chandel NS. Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins. The Journal of Biological Chemistry. 277: 15654-60. PMID 11877388 DOI: 10.1074/jbc.M109317200  0.32
2002 Lee VY, McClintock DS, Santore MT, Budinger GR, Chandel NS. Hypoxia sensitizes cells to nitric oxide-induced apoptosis. The Journal of Biological Chemistry. 277: 16067-74. PMID 11861645 DOI: 10.1074/jbc.M111177200  0.32
2002 McClintock DS, Santore MT, Lee VY, Brunelle J, Budinger GR, Zong WX, Thompson CB, Hay N, Chandel NS. Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Molecular and Cellular Biology. 22: 94-104. PMID 11739725  0.32
1999 Ali MH, Schlidt SA, Chandel NS, Hynes KL, Schumacker PT, Gewertz BL. Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction. American Journal of Physiology. Lung Cellular and Molecular Physiology. 277: L1057-L1065. PMID 29592305 DOI: 10.1152/ajplung.1999.277.5.L1057  0.32
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