Ethan Dmitrovsky - Publications

Affiliations: 
Pharmacology and Toxicology Dartmouth College, Hanover, NH, United States 
Area:
Pharmacology, Biochemistry, General

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Liu X, Lu Y, Chen Z, Liu X, Hu W, Zheng L, Chen Y, Kurie JM, Shi M, Mustachio LM, Andresson T, Fox S, Roszik J, Kawakami M, Freemantle S, ... Dmitrovsky E, et al. The Ubiquitin Specific Protease USP18 Promotes Lipolysis, Fatty Acid Oxidation and Lung Cancer Growth. Molecular Cancer Research : McR. PMID 33380466 DOI: 10.1158/1541-7786.MCR-20-0579  0.44
2020 Kawakami M, Mustachio LM, Chen Y, Chen Z, Liu X, Wei CH, Roszik J, Kittai AS, Danilov AV, Zhang X, Fang B, Wang J, Heymach JV, Tyutyunyk-Massey L, Freemantle SJ, ... ... Dmitrovsky E, et al. A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis and Metastasis in Aneuploid Cancers. Molecular Cancer Therapeutics. PMID 33277443 DOI: 10.1158/1535-7163.MCT-19-0987  0.44
2020 Dmitrovsky E, Kawakami M, Liu XI, Freemantle SJ, Kurie JM. TRIGGERING ANAPHASE CATASTROPHE TO COMBAT ANEUPLOID CANCERS. Transactions of the American Clinical and Climatological Association. 131: 82-94. PMID 32675848  0.44
2020 Liu X, Lu Y, Chen Z, Liu X, Hu W, Zheng L, Chen Y, Shi M, Mustachio L, Roszik J, Kawakami M, Freemantle S, Dmitrovsky E. Abstract 2547: USP18 promotes lipolysis, fatty acid oxidation and lung cancer growth Cancer Research. 80: 2547-2547. DOI: 10.1158/1538-7445.Am2020-2547  0.44
2019 Zheng L, Chen Z, Kawakami M, Chen Y, Roszik J, Mustachio LM, Kurie JM, Villalobos P, Lu W, Behren C, Mino B, Solis LM, Silvester J, Thu KL, Cescon DW, ... ... Dmitrovsky E, et al. Threonine Tyrosine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy. Molecular Cancer Therapeutics. PMID 31358662 DOI: 10.1158/1535-7163.Mct-18-0864  0.44
2018 Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, ... Dmitrovsky E, et al. Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 30377273 DOI: 10.1073/Pnas.1813967115  0.44
2018 Kawakami M, Mustachio LM, Liu X, Dmitrovsky E. Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers. Molecular Cancer Therapeutics. PMID 29559545 DOI: 10.1158/1535-7163.MCT-17-1108  0.44
2018 Mustachio LM, Lu Y, Kawakami M, Roszik J, Freemantle SJ, Liu X, Dmitrovsky E. Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target. Cancer Research. PMID 29343520 DOI: 10.1158/0008-5472.Can-17-1752  0.44
2017 Yim CY, Bikorimana E, Khan E, Warzecha JM, Shin L, Rodriguez J, Dmitrovsky E, Freemantle SJ, Spinella MJ. G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer. Cell Cycle (Georgetown, Tex.). 1-10. PMID 28910567 DOI: 10.1080/15384101.2017.1371884  0.48
2017 Kawakami M, Mustachio LM, Rodriguez-Canales J, Mino B, Roszik J, Tong P, Wang J, Lee JJ, Myung JH, Heymach JV, Johnson FM, Hong S, Zheng L, Hu S, Villalobos PA, ... ... Dmitrovsky E, et al. Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer. Journal of the National Cancer Institute. 109. PMID 28376145 DOI: 10.1093/Jnci/Djw297  0.44
2017 Mustachio LM, Lu Y, Tafe LJ, Memoli V, Rodriguez-Canales J, Mino B, Villalobos PA, Wistuba I, Katayama H, Hanash SM, Roszik J, Kawakami M, Cho KJ, Hancock JF, Chinyengetere F, ... ... Dmitrovsky E, et al. Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer. Molecular Cancer Research : McR. PMID 28242811 DOI: 10.1158/1541-7786.Mcr-16-0369  0.44
2016 Mustachio LM, Kawakami M, Lu Y, Rodriguez-Canales J, Mino B, Behrens C, Wistuba I, Bota-Rabassedas N, Yu J, Lee JJ, Roszik J, Zheng L, Liu X, Freemantle SJ, Dmitrovsky E. The ISG15-specific protease USP18 regulates stability of PTEN. Oncotarget. PMID 27980214 DOI: 10.18632/Oncotarget.13914  0.44
2016 Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ, Dmitrovsky E. Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin Dependent Kinases 1 and 2. Molecular Cancer Therapeutics. PMID 27550941 DOI: 10.1158/1535-7163.Mct-16-0127  0.48
2016 Yim CY, Sekula D, Hever-Jardine MP, Liu X, Warzecha JM, Tam J, Freemantle SJ, Dmitrovsky E, Spinella MJ. G0S2 suppresses oncogenic transformation by repressing a Myc-regulated transcriptional program. Cancer Research. PMID 26837760 DOI: 10.1158/0008-5472.Can-15-2265  0.48
2015 Chinyengetere F, Sekula DJ, Lu Y, Giustini AJ, Sanglikar A, Kawakami M, Ma T, Burkett SS, Eisenberg BL, Wells WA, Hoopes PJ, Demicco EG, Lazar AJ, Torres KE, Memoli V, ... ... Dmitrovsky E, et al. Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas. Bmc Cancer. 15: 886. PMID 26555296 DOI: 10.1186/S12885-015-1883-8  0.48
2015 Myung JH, Roengvoraphoj M, Tam KA, Ma T, Memoli VA, Dmitrovsky E, Freemantle SJ, Hong S. Effective Capture of Circulating Tumor Cells from a Transgenic Mouse Lung Cancer Model Using Dendrimer Surfaces Immobilized with Anti-EGFR. Analytical Chemistry. 87: 10096-102. PMID 26312815 DOI: 10.1021/Acs.Analchem.5B02766  0.48
2015 Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E. Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown. Molecular Cancer Therapeutics. PMID 26304236 DOI: 10.1158/1535-7163.Mct-15-0443  0.48
2015 Liu X, Gold KA, Dmitrovsky E. The Myb-p300 Interaction Is a Novel Molecular Pharmacologic Target. Molecular Cancer Therapeutics. 14: 1273-5. PMID 25995438 DOI: 10.1158/1535-7163.MCT-15-0271  0.48
2015 Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, ... ... Dmitrovsky E, et al. CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110. Cancer Research. 75: 2029-38. PMID 25808870 DOI: 10.1158/0008-5472.Can-14-1494  0.48
2015 Gui J, Hu Z, Tsai CY, Ma T, Song Y, Morales A, Huang LH, Dmitrovsky E, Craig RW, Usherwood EJ. MCL1 enhances the survival of CD8+ memory T Cells after viral infection. Journal of Virology. 89: 2405-14. PMID 25505074 DOI: 10.1128/Jvi.02480-14  0.48
2015 Kawakami M, Mustachio LM, Liu X, Hu S, Lu Y, Sekula D, Freemantle S, Dmitrovsky E. Abstract 942: Novel CDK2/9 inhibitor has antineoplastic activity in lung cancer by inducing anaphase catastrophe Cancer Research. 75: 942-942. DOI: 10.1158/1538-7445.Am2015-942  0.44
2015 Yim CY, Sekula DJ, Freemantle SJ, Dmitrovsky E, Spinella MJ. Abstract 2026: G0S2 functions as a tumor suppressor gene through inhibition of c-Myc Cancer Research. 75: 2026-2026. DOI: 10.1158/1538-7445.Am2015-2026  0.48
2015 Myung JH, Roengvoraphoj M, Tam KA, Ma T, Memoli VA, Dmitrovsky E, Freemantle SJ, Hong S. Effective Capture of Circulating Tumor Cells from a Transgenic Mouse Lung Cancer Model Using Dendrimer Surfaces Immobilized with Anti-EGFR Analytical Chemistry. 87: 10096-10102. DOI: 10.1021/acs.analchem.5b02766  0.48
2014 Ma T, Lopez-Aguiar AG, Li A, Lu Y, Sekula D, Nattie EE, Freemantle S, Dmitrovsky E. Mice lacking G0S2 are lean and cold-tolerant. Cancer Biology & Therapy. 15: 643-50. PMID 24556704 DOI: 10.4161/Cbt.28251  0.48
2014 Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biology & Therapy. 15: 463-72. PMID 24496080 DOI: 10.4161/Cbt.27821  0.48
2014 Hu S, Danilov AV, Godek KM, Orr B, Tafe LJ, Memoli VA, Galimberti F, Ravi S, DeCastro AJ, Lu Y, Mustachio LM, Sekula DJ, Andrew AS, Freemantle SJ, Compton DA, ... Dmitrovsky E, et al. Abstract 4549: CDK2 inhibition causes anaphase catastrophe through the centrosomal protein CP110 Cancer Research. 74: 4549-4549. DOI: 10.1158/1538-7445.Am2014-4549  0.48
2014 Mustachio LM, Chinyengetere F, Lu Y, Hu S, Kawakami M, Tafe LJ, Danilov A, Sekula DJ, Ma T, Freemantle SJ, Dmitrovsky E. Abstract 1782: The ubiquitin protease UBP43 is a target for KRAS mutant lung cancers Cancer Research. 74: 1782-1782. DOI: 10.1158/1538-7445.Am2014-1782  0.44
2013 Aoyama K, Saha A, Tolar J, Riddle MJ, Veenstra RG, Taylor PA, Blomhoff R, Panoskaltsis-Mortari A, Klebanoff CA, Socié G, Munn DH, Murphy WJ, Serody JS, Fulton LM, Teshima T, ... ... Dmitrovsky E, et al. Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration. Blood. 122: 2125-34. PMID 23814022 DOI: 10.1182/Blood-2012-11-470252  0.48
2013 Ma T, Galimberti F, Erkmen CP, Memoli V, Chinyengetere F, Sempere L, Beumer JH, Anyang BN, Nugent W, Johnstone D, Tsongalis GJ, Kurie JM, Li H, Direnzo J, Guo Y, ... ... Dmitrovsky E, et al. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Molecular Cancer Therapeutics. 12: 1545-55. PMID 23686769 DOI: 10.1158/1535-7163.Mct-12-0933  0.48
2013 Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ. Evidence for tankyrases as antineoplastic targets in lung cancer. Bmc Cancer. 13: 211. PMID 23621985 DOI: 10.1186/1471-2407-13-211  0.48
2013 Ma T, Dong JP, Sekula DJ, Fei DL, Lamph WW, Henderson M, Lu Y, Blumen S, Freemantle SJ, Dmitrovsky E. Repression of exogenous gene expression by the retinoic acid target gene G0S2. International Journal of Oncology. 42: 1743-53. PMID 23546556 DOI: 10.3892/Ijo.2013.1876  0.48
2013 Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang Fei D, Singh S, Black KE, Wang Z, Galimberti F, Bejarano PA, Elliot S, Glassberg MK, Nguyen DM, Lockwood WW, ... ... Dmitrovsky E, et al. The hedgehog processing pathway is required for NSCLC growth and survival. Oncogene. 32: 2335-45. PMID 22733134 DOI: 10.1038/Onc.2012.243  0.48
2013 Lu Y, Mustachio LM, Chinyengetere F, Yang W, Ma T, Dong J, Sekula DJ, Freemantle SJ, Dmitrovsky E. Abstract 4125: The retinoid-induced G0S2 protein undergoes ISG15ylation and destabilization. Cancer Research. 73: 4125-4125. DOI: 10.1158/1538-7445.Am2013-4125  0.44
2013 Chinyengetere F, Giustini A, Sekula D, Freemantle S, Memoli VA, Hoopes PJ, Dmitrovsky E. Abstract 1089: Spontaneous formation of sarcomas in Usp18 knockout mice. Cancer Research. 73: 1089-1089. DOI: 10.1158/1538-7445.Am2013-1089  0.48
2012 Ma T, Fuld AD, Rigas JR, Hagey AE, Gordon GB, Dmitrovsky E, Dragnev KH. A phase I trial and in vitro studies combining ABT-751 with carboplatin in previously treated non-small cell lung cancer patients. Chemotherapy. 58: 321-9. PMID 23147218 DOI: 10.1159/000343165  0.4
2012 Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, ... ... Dmitrovsky E, et al. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. International Journal of Oncology. 41: 1751-61. PMID 22923130 DOI: 10.3892/Ijo.2012.1599  0.48
2012 Guo Y, Pino-Lagos K, Ahonen CA, Bennett KA, Wang J, Napoli JL, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Turk MJ, Noelle RJ. A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells. Cancer Research. 72: 5230-9. PMID 22902413 DOI: 10.1158/0008-5472.Can-12-1727  0.48
2012 Guo Y, Chinyengetere F, Dolinko AV, Lopez-Aguiar A, Lu Y, Galimberti F, Ma T, Feng Q, Sekula D, Freemantle SJ, Andrew AS, Memoli V, Dmitrovsky E. Evidence for the ubiquitin protease UBP43 as an antineoplastic target. Molecular Cancer Therapeutics. 11: 1968-77. PMID 22752428 DOI: 10.1158/1535-7163.Mct-12-0248  0.48
2012 Busch AM, Johnson KC, Tacchelly O, Wang Z, Ahmed YF, Dmitrovsky E, Freemantle SJ. Abstract 973: Tankyrase inhibition represses Wnt signaling and lung cancer growth Cancer Research. 72: 973-973. DOI: 10.1158/1538-7445.Am2012-973  0.48
2012 Ma T, Dong JP, Blumen S, Fei DL, Henderson M, Sekula DJ, Freemantle SJ, Dmitrovsky E. Abstract 4732: Repression of transcriptional activity by the retinoid target gene G0S2 Cancer Research. 72: 4732-4732. DOI: 10.1158/1538-7445.Am2012-4732  0.44
2011 Dragnev KH, Ma T, Galimberti F, Erkmen CP, Memoli V, Nugent W, Rigas JR, Johnstone D, Frandsen A, Simeone S, Czum J, Li H, DiRenzo J, Freemantle S, Dmitrovsky E. A window-of-opportunity trial of vorinostat (V) in patients with resectable non-small cell lung cancer (NSCLC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 7062. PMID 28020374 DOI: 10.1200/Jco.2011.29.15_Suppl.7062  0.48
2011 Pino-Lagos K, Guo Y, Brown C, Alexander MP, Elgueta R, Bennett KA, De Vries V, Nowak E, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Noelle RJ. A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity. The Journal of Experimental Medicine. 208: 1767-75. PMID 21859847 DOI: 10.1084/Jem.20102358  0.48
2011 Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, ... ... Dmitrovsky E, et al. Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models. Cancer Prevention Research (Philadelphia, Pa.). 4: 818-28. PMID 21636548 DOI: 10.1158/1940-6207.Capr-10-0376  0.48
2011 Singh S, Wang Z, Liang Fei D, Black KE, Goetz JA, Tokhunts R, Giambelli C, Rodriguez-Blanco J, Long J, Lee E, Briegel KJ, Bejarano PA, Dmitrovsky E, Capobianco AJ, Robbins DJ. Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Research. 71: 4454-63. PMID 21565978 DOI: 10.1158/0008-5472.Can-10-2313  0.48
2011 Liu X, Sempere LF, Guo Y, Korc M, Kauppinen S, Freemantle SJ, Dmitrovsky E. Involvement of microRNAs in lung cancer biology and therapy. Translational Research : the Journal of Laboratory and Clinical Medicine. 157: 200-8. PMID 21420030 DOI: 10.1016/J.Trsl.2011.01.001  0.48
2011 Galimberti F, Thompson SL, Ravi S, Compton DA, Dmitrovsky E. Anaphase catastrophe is a target for cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1218-22. PMID 21288923 DOI: 10.1158/1078-0432.Ccr-10-1178  0.48
2011 Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer MA, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, ... ... Dmitrovsky E, et al. Abstract LB-412: Combining bexarotene with erlotinib in window of opportunity and phase II trials causes lung cancer responses independent of KRAS mutations Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-412  0.48
2011 Ma T, Galimberti F, Erkmen CP, Memoli V, Nugent W, Rigas J, Johnstone D, Li H, DiRenzo J, Freemantle S, Dragnev K, Dmitrovsky E. Abstract 342: Murine transgenic lung cancer models guide a proof of principle histone deacetylase inhibitor trial in lung cancer patients Cancer Research. 71: 342-342. DOI: 10.1158/1538-7445.Am2011-342  0.48
2011 Guo Y, Chinyengetere F, Dolinko AV, Lopez-Aguiar A, Galimberti F, Ma T, Feng Q, Andrew AS, Sekula D, Freemantle S, Memoli V, Dmitrovsky E. Abstract 1655: The ubiquitin protease UBP43 is a target for lung cancer therapy and prevention Cancer Research. 71: 1655-1655. DOI: 10.1158/1538-7445.Am2011-1655  0.48
2011 Galimberti F, Busch A, Chinyengetere F, Ma T, Sekula D, Memoli V, Dragnev K, Liu F, Andrew AS, Greninger P, Robbins D, Settleman J, Benes C, Dmitrovsky E. Abstract 1615: Gene expression profile predicts response to smoothened inhibitors in epithelial cancers Cancer Research. 71: 1615-1615. DOI: 10.1158/1538-7445.Am2011-1615  0.48
2010 Freemantle SJ, Dmitrovsky E. Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention. Cancer Prevention Research (Philadelphia, Pa.). 3: 1513-8. PMID 21149327 DOI: 10.1158/1940-6207.Capr-10-0297  0.4
2010 Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Freemantle S, Dmitrovsky E. Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia. Cancer Research. 70: 9875-85. PMID 20935222 DOI: 10.1158/0008-5472.Can-10-1100  0.48
2010 Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, ... ... Dmitrovsky E, et al. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. The Journal of Clinical Investigation. 120: 1298-309. PMID 20237410 DOI: 10.1172/Jci39566  0.48
2010 Galimberti F, Thompson SL, Liu X, Li H, Memoli V, Green SR, DiRenzo J, Greninger P, Sharma SV, Settleman J, Compton DA, Dmitrovsky E. Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 109-20. PMID 20028770 DOI: 10.1158/1078-0432.Ccr-09-2151  0.48
2010 Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Liu H, DiRenzo J, Bak M, Kauppinen S, ... ... Dmitrovsky E, et al. Abstract 5698: MicroRNA-31 acts as an oncomir in lung cancer by repressing specific tumor suppressors Cancer Research. 70: 5698-5698. DOI: 10.1158/1538-7445.Am10-5698  0.48
2010 Beyrouthy MJ, Garner K, Hever MP, Freemantle SJ, Eastman A, Dmitrovsky E, Spinella MJ. Abstract 4273: DNA methyltransferase 3B mediates 5-aza-deoxycytidine hypersensitivity in cisplatin-sensitive and cisplatin-resistant pluripotent embryonal carcinoma cells Cancer Research. 70: 4273-4273. DOI: 10.1158/1538-7445.Am10-4273  0.48
2010 Guo Y, Dolinko A, Chinyengetere F, Bomberger J, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Busch A, Freemantle S, Dmitrovsky E. Abstract 1594: Targeting UBP43 for repression destabilizes PML/RARα and inhibits acute promyelocytic leukemia growth Cancer Research. 70: 1594-1594. DOI: 10.1158/1538-7445.Am10-1594  0.48
2009 Beyrouthy MJ, Garner KM, Hever MP, Freemantle SJ, Eastman A, Dmitrovsky E, Spinella MJ. High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors. Cancer Research. 69: 9360-6. PMID 19951990 DOI: 10.1158/0008-5472.Can-09-1490  0.48
2009 Snow GE, Kasper AC, Busch AM, Schwarz E, Ewings KE, Bee T, Spinella MJ, Dmitrovsky E, Freemantle SJ. Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting. Bmc Cancer. 9: 383. PMID 19874621 DOI: 10.1186/1471-2407-9-383  0.48
2009 Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Yan M, Fiering S, Memoli V, Li H, Direnzo J, Korc M, Cole CN, Bak M, Kauppinen S, ... Dmitrovsky E, et al. Uncovering growth-Suppressive micro rNAs in lung cancer Clinical Cancer Research. 15: 1177-1183. PMID 19228723 DOI: 10.1158/1078-0432.Ccr-08-1355  0.48
2009 Freemantle SJ, Guo Y, Dmitrovsky E. Retinoid chemoprevention trials: cyclin D1 in the crosshairs. Cancer Prevention Research (Philadelphia, Pa.). 2: 3-6. PMID 19139010 DOI: 10.1158/1940-6207.Capr-08-0218  0.48
2008 Feng Q, Sekula D, Guo Y, Liu X, Black CC, Galimberti F, Shah SJ, Sempere LF, Memoli V, Andersen JB, Hassel BA, Dragnev K, Dmitrovsky E. UBE1L causes lung cancer growth suppression by targeting cyclin D1. Molecular Cancer Therapeutics. 7: 3780-8. PMID 19074853 DOI: 10.1158/1535-7163.Mct-08-0753  0.48
2008 Kitareewan S, Blumen S, Sekula D, Bissonnette RP, Lamph WW, Cui Q, Gallagher R, Dmitrovsky E. G0S2 is an all-trans-retinoic acid target gene. International Journal of Oncology. 33: 397-404. PMID 18636162 DOI: 10.3892/Ijo_00000021  0.32
2008 Liby K, Black CC, Royce DB, Williams CR, Risingsong R, Yore MM, Liu X, Honda T, Gribble GW, Lamph WW, Sporn TA, Dmitrovsky E, Sporn MB. The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis Molecular Cancer Therapeutics. 7: 1251-1257. PMID 18483313 DOI: 10.1158/1535-7163.Mct-08-0023  0.48
2008 Shah SJ, Blumen S, Pitha-Rowe I, Kitareewan S, Freemantle SJ, Feng Q, Dmitrovsky E. UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation. Molecular Cancer Therapeutics. 7: 905-14. PMID 18413804 DOI: 10.1158/1535-7163.Mct-07-0515  0.4
2008 Liu X, Sempere L, Galimberti F, Freemantle S, Black C, Fiering S, Cole C, Dragnev K, Memoli V, Korc M, Li H, DiRenzo J, Bak M, Kauppinen S, Dmitrovsky E. Abstract A135: Uncovering tumor suppressive and oncogenic microRNAs in lung cancer Cancer Prevention Research. 1. DOI: 10.1158/1940-6207.Prev-08-A135  0.48
2007 Freemantle SJ, Liu X, Feng Q, Galimberti F, Blumen S, Sekula D, Kitareewan S, Dragnev KH, Dmitrovsky E. Cyclin degradation for cancer therapy and chemoprevention. Journal of Cellular Biochemistry. 102: 869-77. PMID 17868090 DOI: 10.1002/Jcb.21519  0.48
2007 Liby K, Royce DB, Williams CR, Risingsong R, Yore MM, Honda T, Gribble GW, Dmitrovsky E, Sporn TA, Sporn MB. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice Cancer Research. 67: 2414-2419. PMID 17363558 DOI: 10.1158/0008-5472.Can-06-4534  0.48
2007 Dragnev KH, Petty WJ, Shah SJ, Lewis LD, Black CC, Memoli V, Nugent WC, Hermann T, Negro-Vilar A, Rigas JR, Dmitrovsky E. A proof-of-principle clinical trial of bexarotene in patients with non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 1794-800. PMID 17363535 DOI: 10.1158/1078-0432.Ccr-06-1836  0.48
2007 Ma Y, Fiering S, Black C, Liu X, Yuan Z, Memoli VA, Robbins DJ, Bentley HA, Tsongalis GJ, Demidenko E, Freemantle SJ, Dmitrovsky E. Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proceedings of the National Academy of Sciences of the United States of America. 104: 4089-94. PMID 17360482 DOI: 10.1073/Pnas.0606537104  0.48
2007 Dragnev KH, Feng Q, Ma Y, Shah SJ, Black C, Memoli V, Nugent W, Rigas JR, Kitareewan S, Freemantle S, Dmitrovsky E. Uncovering novel targets for cancer chemoprevention. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 174: 235-43. PMID 17302201 DOI: 10.1016/S1359-6349(06)80508-2  0.4
2007 Freemantle SJ, Vaseva AV, Ewings KE, Bee T, Krizan KA, Kelley MR, Hattab EM, Memoli VA, Black CC, Spinella MJ, Dmitrovsky E. Repression of cyclin D1 as a target for germ cell tumors. International Journal of Oncology. 30: 333-40. PMID 17203214 DOI: 10.3892/Ijo.30.2.333  0.48
2007 Yuan Z, Goetz JA, Singh S, Ogden SK, Petty WJ, Black CC, Memoli VA, Dmitrovsky E, Robbins DJ. Frequent requirement of hedgehog signaling in non-small cell lung carcinoma. Oncogene. 26: 1046-55. PMID 16909105 DOI: 10.1038/Sj.Onc.1209860  0.48
2006 Freemantle SJ, Dragnev KH, Dmitrovsky E. The retinoic acid paradox in cancer chemoprevention. Journal of the National Cancer Institute. 98: 426-7. PMID 16595769 DOI: 10.1093/Jnci/Djj116  0.4
2005 Rigas JR, Dragnev KH, Petty WJ, Nugent WC, Memoli VA, Black CC, Lewis LD, Loewen G, Negro-Vilar A, Dmitrovsky E. A proof-of-principle trial of bexarotene in patients (pts) with resectable non-small cell lung cancer (NSCLC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 7136. PMID 27944958 DOI: 10.1200/jco.2005.23.16_suppl.7136  0.4
2005 Petty WJ, Dragnev KH, Black WC, Cole BF, Hammond S, Williams I, Dmitrovsky E, Rigas JR. Weekly paclitaxel, carboplatin, and bexarotene for the treatment of patients with advanced non-small cell lung cancer: Efficacy results from a phase I/II study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 7243. PMID 27944733 DOI: 10.1200/jco.2005.23.16_suppl.7243  0.4
2005 Dragnev KH, Petty WJ, Shah S, Carey MA, Disalvo WM, Williams I, Rigas JR, Dmitrovsky E. A phase I trial of erlotinib and bexarotene as a targeted combination therapy for aerodigestive tract cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 7093. PMID 27944555 DOI: 10.1200/jco.2005.23.16_suppl.7093  0.4
2005 Dragnev KH, Petty WJ, Shah S, Biddle A, Desai NB, Memoli V, Rigas JR, Dmitrovsky E. Bexarotene and erlotinib for aerodigestive tract cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 8757-64. PMID 16314636 DOI: 10.1200/Jco.2005.01.9521  0.4
2005 Petty WJ, Li N, Biddle A, Bounds R, Nitkin C, Ma Y, Dragnev KH, Freemantle SJ, Dmitrovsky E. A novel retinoic acid receptor beta isoform and retinoid resistance in lung carcinogenesis. Journal of the National Cancer Institute. 97: 1645-51. PMID 16288117 DOI: 10.1093/Jnci/Dji371  0.4
2005 Giuliano CJ, Kerley-Hamilton JS, Bee T, Freemantle SJ, Manickaratnam R, Dmitrovsky E, Spinella MJ. Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochimica Et Biophysica Acta. 1731: 48-56. PMID 16168501 DOI: 10.1016/J.Bbaexp.2005.08.006  0.48
2005 Ma Y, Feng Q, Sekula D, Diehl JA, Freemantle SJ, Dmitrovsky E. Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Research. 65: 6476-83. PMID 16024653 DOI: 10.1158/0008-5472.Can-05-0370  0.48
2005 Dragnev KH, Petty WJ, Ma Y, Rigas JR, Dmitrovsky E. Nonclassical retinoids and lung carcinogenesis. Clinical Lung Cancer. 6: 237-44. PMID 15694016 DOI: 10.3816/Clc.2005.N.003  0.4
2004 Petty WJ, Dragnev KH, Memoli VA, Davis TH, Nugent WC, Williams IR, Iwata KK, Hamilton M, Rigas JR, Dmitrovsky E. Cyclin D1 repression as a marker of erlotinib response in aerodigestive tract cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 3093. PMID 28014792 DOI: 10.1200/jco.2004.22.14_suppl.3093  0.4
2004 Petty WJ, Dragnev KH, Memoli VA, Ma Y, Desai NB, Biddle A, Davis TH, Nugent WC, Memoli N, Hamilton M, Iwata KK, Rigas JR, Dmitrovsky E. Epidermal growth factor receptor tyrosine kinase inhibition represses cyclin D1 in aerodigestive tract cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 7547-54. PMID 15569985 DOI: 10.1158/1078-0432.Ccr-04-1169  0.48
2004 Pitha-Rowe I, Petty WJ, Feng Q, Koza-Taylor PH, Dimattia DA, Pinder L, Dragnev KH, Memoli N, Memoli V, Turi T, Beebe J, Kitareewan S, Dmitrovsky E. Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention. Cancer Research. 64: 8109-15. PMID 15520223 DOI: 10.1158/0008-5472.Can-03-3938  0.4
2004 Dragnev KH, Pitha-Rowe I, Ma Y, Petty WJ, Sekula D, Murphy B, Rendi M, Suh N, Desai NB, Sporn MB, Freemantle SJ, Dmitrovsky E. Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 2570-7. PMID 15073138 DOI: 10.1158/1078-0432.Ccr-03-0271  0.48
2004 Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biology. 5: R13. PMID 15003116 DOI: 10.1186/Gb-2004-5-3-R13  0.48
2003 Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene. 22: 7305-15. PMID 14576840 DOI: 10.1038/Sj.Onc.1206936  0.48
2003 Ma Y, Koza-Taylor PH, DiMattia DA, Hames L, Fu H, Dragnev KH, Turi T, Beebe JS, Freemantle SJ, Dmitrovsky E. Microarray analysis uncovers retinoid targets in human bronchial epithelial cells. Oncogene. 22: 4924-32. PMID 12894236 DOI: 10.1038/Sj.Onc.1206728  0.4
2003 Dragnev KH, Stover D, Dmitrovsky E. Lung cancer prevention: the guidelines. Chest. 123: 60S-71S. PMID 12527565 DOI: 10.1378/Chest.123.1_Suppl.60S  0.48
2002 Freemantle SJ, Portland HB, Ewings K, Dmitrovsky F, DiPetrillo K, Spinella MJ, Dmitrovsky E. Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. Gene. 291: 17-27. PMID 12095675 DOI: 10.1016/S0378-1119(02)00594-2  0.48
2002 Kitareewan S, Pitha-Rowe I, Sekula D, Lowrey CH, Nemeth MJ, Golub TR, Freemantle SJ, Dmitrovsky E. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 99: 3806-11. PMID 11891284 DOI: 10.1073/Pnas.052011299  0.48
2002 Freemantle SJ, Dmitrovsky E. Clinical link between p53 and angiogenesis in lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 20: 883-4. PMID 11844804 DOI: 10.1200/Jco.2002.20.4.883  0.4
2002 Lonardo F, Dragnev KH, Freemantle SJ, Ma Y, Memoli N, Sekula D, Knauth EA, Beebe JS, Dmitrovsky E. Evidence for the epidermal growth factor receptor as a target for lung cancer prevention. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 54-60. PMID 11801540  0.48
2001 Dragnev KH, Freemantle SJ, Spinella MJ, Dmitrovsky E. Cyclin proteolysis as a retinoid cancer prevention mechanism. Annals of the New York Academy of Sciences. 952: 13-22. PMID 11795432 DOI: 10.1111/J.1749-6632.2001.Tb02724.X  0.48
2001 Curtin JC, Dragnev KH, Sekula D, Christie AJ, Dmitrovsky E, Spinella MJ. Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function. Oncogene. 20: 2559-69. PMID 11420666 DOI: 10.1038/Sj.Onc.1204370  0.48
2001 Pitts JD, Sloboda RD, Dragnev KH, Dmitrovsky E, Mycek MA. Autofluorescence characteristics of immortalized and carcinogen-transformed human bronchial epithelial cells. Journal of Biomedical Optics. 6: 31-40. PMID 11178578 DOI: 10.1117/1.1333057  0.48
2000 Spinella MJ, Dmitrovsky E. Aberrant retinoid signaling and breast cancer: the view from outside the nucleus. Journal of the National Cancer Institute. 92: 438-40. PMID 10716952 DOI: 10.1093/Jnci/92.6.438  0.48
1999 Kitareewan S, Spinella MJ, Allopenna J, Reczek PR, Dmitrovsky E. 4HPR triggers apoptosis but not differentiation in retinoid sensitive and resistant human embryonal carcinoma cells through an RARgamma independent pathway. Oncogene. 18: 5747-55. PMID 10523855 DOI: 10.1038/Sj.Onc.1202981  0.48
1999 Hromas R, Ye H, Spinella M, Dmitrovsky E, Xu D, Costa RH. Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model. Cell and Tissue Research. 297: 371-82. PMID 10460485 DOI: 10.1007/S004410051365  0.48
1999 Spinella MJ, Freemantle SJ, Sekula D, Chang JH, Christie AJ, Dmitrovsky E. Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation. The Journal of Biological Chemistry. 274: 22013-8. PMID 10419526 DOI: 10.1074/Jbc.274.31.22013  0.48
1999 Yang WL, Zeng YX, El-Deiry WS, Nason-Burchenal K, Dmitrovsky E, Chin KV. Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARα Molecular Cell Biology Research Communications. 1: 125-131. PMID 10356361 DOI: 10.1006/Mcbr.1999.0121  0.48
1998 Nason-Burchenal K, Takle G, Pace U, Flynn S, Allopenna J, Martin P, George ST, Goldberg AR, Dmitrovsky E. Targeting the PML/RAR alpha translocation product triggers apoptosis in promyelocytic leukemia cells. Oncogene. 17: 1759-68. PMID 9778041 DOI: 10.1038/Sj.Onc.1202075  0.48
1998 Maerz WJ, Baselga J, Reuter VE, Mellado B, Myers ML, Bosl GJ, Spinella MJ, Dmitrovsky E. FGF4 dissociates anti-tumorigenic from differentiation signals of retinoic acid in human embryonal carcinomas Oncogene. 17: 761-767. PMID 9715278 DOI: 10.1038/Sj.Onc.1201992  0.48
1998 Spinella MJ, Kitareewan S, Mellado B, Sekula D, Khoo KS, Dmitrovsky E. Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells. Oncogene. 16: 3471-80. PMID 9692555 DOI: 10.1038/Sj.Onc.1201876  0.48
1997 Lei W, Hirose T, Zhang LX, Adachi H, Spinella MJ, Dmitrovsky E, Jetten AM. Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation. Journal of Molecular Endocrinology. 18: 167-76. PMID 9134503 DOI: 10.1677/Jme.0.0180167  0.48
1992 Muindi J, Frankel SR, Miller WH, Jakubowski A, Scheinberg DA, Young CW, Dmitrovsky E, Warrell RP. Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia. Blood. 79: 299-303. PMID 1309668 DOI: 10.1182/Blood.V79.2.299.Bloodjournal792299  0.48
1990 Dmitrovsky E, Seifter EJ, Gazdar AF, Tsai CM, Edison M, Brantley P, Veach SR, Batist G, Ihde DC, Mulshine JL. A phase II trial of carboplatin (CBDCA) in small-cell and non-small-cell lung cancer with correlation to in vitro analysis of cytotoxicity. American Journal of Clinical Oncology. 13: 285-9. PMID 2165737 DOI: 10.1097/00000421-199008000-00003  0.48
1987 Dmitrovsky E, Matthews MJ, Bunn PA, Schechter GP, Makuch RW, Winkler CF, Eddy J, Sausville EA, Ihde DC. Cytologic transformation in cutaneous T cell lymphoma: a clinicopathologic entity associated with poor prognosis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 5: 208-15. PMID 3492594  0.48
1986 Chang H, Dmitrovsky E, Hieter PA, Mitchell K, Leder P, Turoczi L, Kirsch IR, Hollis GF. Identification of three new Ig lambda-like genes in man. The Journal of Experimental Medicine. 163: 425-35. PMID 3003227 DOI: 10.1084/jem.163.2.425  0.48
1978 Dmitrovsky E, Lane LB, Bullough PG. The characterization of the tidemark in human articular cartilage Metabolic Bone Disease and Related Research. 1: 115-118. DOI: 10.1016/0221-8747(78)90047-4  0.48
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