Guri Giaever - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Genetics, Molecular Chemistry, Oncology

109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Giaever G, Lissina E, Nislow C. Network dynamics of the yeast methyltransferome. Microbial Cell (Graz, Austria). 6: 356-369. PMID 31403050 DOI: 10.15698/mic2019.08.687  0.36
2019 Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J. Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nature Chemical Biology. PMID 30833779 DOI: 10.1038/s41589-019-0255-0  0.36
2019 Nawrotek A, Benabdi S, Niyomchon S, Kryszke MH, Ginestier C, Cañeque T, Tepshi L, Mariani A, St Onge RP, Giaever G, Nislow C, Charafe-Jauffret E, Rodriguez R, Zeghouf M, Cherfils J. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nature Chemical Biology. PMID 30742123 DOI: 10.1038/s41589-019-0228-3  0.36
2018 Hammond TG, Allen PL, Gunter MA, Chiang J, Giaever G, Nislow C, Birdsall HH. Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations. Microgravity Science and Technology. 30: 195-208. PMID 31258252 DOI: 10.1007/s12217-017-9588-z  0.36
2018 Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, ... ... Giaever G, et al. Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids". Mbio. 9. PMID 29535196 DOI: 10.1128/mBio.00188-18  0.36
2017 Acton E, Lee AH, Zhao PJ, Flibotte S, Neira M, Sinha S, Chiang J, Flaherty P, Nislow C, Giaever G. Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress. Open Biology. 7. PMID 28592509 DOI: 10.1098/rsob.160330  0.36
2017 Wong LH, Flibotte S, Sinha S, Chiang J, Giaever G, Nislow C. Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant. G3 (Bethesda, Md.). PMID 28235825 DOI: 10.1534/g3.116.038117  0.36
2016 Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, ... ... Giaever G, et al. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. Acs Central Science. 2: 687-701. PMID 27800551 DOI: 10.1021/acscentsci.6b00086  0.36
2016 Mathew MD, Mathew ND, Miller A, Simpson M, Au V, Garland S, Gestin M, Edgley ML, Flibotte S, Balgi A, Chiang J, Giaever G, Dean P, Tung A, Roberge M, et al. Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity. Plos Neglected Tropical Diseases. 10: e0005058. PMID 27755544 DOI: 10.1371/journal.pntd.0005058  0.36
2016 Kwon Y, Cha J, Chiang J, Tran G, Giaever G, Nislow C, Hur JS, Kwak YS. A chemogenomic approach to understand the anti-fungal action of Lichen-derived vulpinic acid. Journal of Applied Microbiology. PMID 27660105 DOI: 10.1111/jam.13300  0.36
2016 Wong LH, Sinha S, Bergeron JR, Mellor JC, Giaever G, Flaherty P, Nislow C. Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions. Plos Genetics. 12: e1006275. PMID 27588687 DOI: 10.1371/journal.pgen.1006275  0.36
2016 Nislow C, Wong LH, Lee AH, Giaever G. Functional Genomics Using the Saccharomyces cerevisiae Yeast Deletion Collections. Cold Spring Harbor Protocols. 2016: pdb.top080945. PMID 27587784 DOI: 10.1101/pdb.top080945  0.36
2016 Suresh S, Schlecht U, Xu W, Bray W, Miranda M, Davis RW, Nislow C, Giaever G, Lokey RS, St Onge RP. Systematic Mapping of Chemical-Genetic Interactions in Saccharomyces cerevisiae. Cold Spring Harbor Protocols. 2016: pdb.top077701. PMID 27587783 DOI: 10.1101/pdb.top077701  0.36
2016 Suresh S, Schlecht U, Xu W, Miranda M, Davis RW, Nislow C, Giaever G, St Onge RP. Identification of Chemical-Genetic Interactions via Parallel Analysis of Barcoded Yeast Strains. Cold Spring Harbor Protocols. 2016: pdb.prot088054. PMID 27587778 DOI: 10.1101/pdb.prot088054  0.36
2016 Nislow C, Wong LH, Lee AH, Giaever G. Functional Profiling Using the Saccharomyces Genome Deletion Project Collections. Cold Spring Harbor Protocols. 2016: pdb.prot088039. PMID 27587776 DOI: 10.1101/pdb.prot088039  0.36
2016 Kwon Y, Chiang J, Tran G, Giaever G, Nislow C, Hahn BS, Kwak YS, Koo JC. Signaling pathways coordinating the alkaline pH response confer resistance to the hevein-type plant antimicrobial peptide Pn-AMP1 in Saccharomyces cerevisiae. Planta. PMID 27510723 DOI: 10.1007/s00425-016-2579-2  0.36
2016 Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SA, Baetz K. A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction. Scientific Reports. 6: 19332. PMID 26757638 DOI: 10.1038/srep19332  0.36
2016 Simoneau A, Ricard É, Weber S, Hammond-Martel I, Wong LH, Sellam A, Giaever G, Nislow C, Raymond M, Wurtele H. Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress. Nucleic Acids Research. PMID 26748095 DOI: 10.1093/nar/gkv1537  0.36
2015 Hamza A, Tammpere E, Kofoed M, Keong C, Chiang J, Giaever G, Nislow C, Hieter P. Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants. Genetics. 201: 1263-74. PMID 26354769 DOI: 10.1534/genetics.115.181099  0.36
2015 Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, et al. Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget. PMID 26353928 DOI: 10.18632/oncotarget.4817  0.36
2015 Kofoed M, Milbury KL, Chiang JH, Sinha S, Ben-Aroya S, Giaever G, Nislow C, Hieter P, Stirling PC. An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes. G3 (Bethesda, Md.). PMID 26175450 DOI: 10.1534/g3.115.019174  0.36
2015 Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, ... ... Giaever G, et al. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nature Communications. 6: 7485. PMID 26108372 DOI: 10.1038/ncomms8485  0.36
2015 Mor V, Rella A, Farnoud AM, Singh A, Munshi M, Bryan A, Naseem S, Konopka JB, Ojima I, Bullesbach E, Ashbaugh A, Linke MJ, Cushion M, Collins M, Ananthula HK, ... ... Giaever G, et al. Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids. Mbio. 6. PMID 26106079 DOI: 10.1128/mBio.00647-15  0.36
2015 Cha JY, Han S, Hong HJ, Cho H, Kim D, Kwon Y, Kwon SK, Crüsemann M, Bok Lee Y, Kim JF, Giaever G, Nislow C, Moore BS, Thomashow LS, Weller DM, et al. Microbial and biochemical basis of a Fusarium wilt-suppressive soil. The Isme Journal. PMID 26057845 DOI: 10.1038/ismej.2015.95  0.36
2015 Bernard D, Gebbia M, Prabha S, Gronda M, MacLean N, Wang X, Hurren R, Sukhai MA, Cho EE, Manolson MF, Datti A, Wrana J, Minden MD, Al-Awar R, Aman A, ... ... Giaever G, et al. Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells. Apoptosis : An International Journal On Programmed Cell Death. 20: 948-59. PMID 25832785 DOI: 10.1007/s10495-015-1123-3  0.36
2015 Nislow C, Lee AY, Allen PL, Giaever G, Smith A, Gebbia M, Stodieck LS, Hammond JS, Birdsall HH, Hammond TG. Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight. Biomed Research International. 2015: 976458. PMID 25667933 DOI: 10.1155/2015/976458  0.36
2014 Arnoldo A, Kittanakom S, Heisler LE, Mak AB, Shukalyuk AI, Torti D, Moffat J, Giaever G, Nislow C. A genome scale overexpression screen to reveal drug activity in human cells. Genome Medicine. 6: 32. PMID 24944581 DOI: 10.1186/gm549  0.36
2014 Giaever G, Nislow C. The yeast deletion collection: a decade of functional genomics. Genetics. 197: 451-65. PMID 24939991 DOI: 10.1534/genetics.114.161620  0.36
2014 Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, ... ... Giaever G, et al. Mapping the cellular response to small molecules using chemogenomic fitness signatures. Science (New York, N.Y.). 344: 208-11. PMID 24723613 DOI: 10.1126/science.1250217  0.36
2014 Cokol M, Weinstein ZB, Yilancioglu K, Tasan M, Doak A, Cansever D, Mutlu B, Li S, Rodriguez-Esteban R, Akhmedov M, Guvenek A, Cokol M, Cetiner S, Giaever G, Iossifov I, et al. Large-scale identification and analysis of suppressive drug interactions. Chemistry & Biology. 21: 541-51. PMID 24704506 DOI: 10.1016/j.chembiol.2014.02.012  0.36
2014 Nile AH, Tripathi A, Yuan P, Mousley CJ, Suresh S, Wallace IM, Shah SD, Pohlhaus DT, Temple B, Nislow C, Giaever G, Tropsha A, Davis RW, St Onge RP, Bankaitis VA. PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nature Chemical Biology. 10: 76-84. PMID 24292071 DOI: 10.1038/nchembio.1389  0.36
2013 Lissina E, Weiss D, Young B, Rella A, Cheung-Ong K, Del Poeta M, Clarke SG, Giaever G, Nislow C. A novel small molecule methyltransferase is important for virulence in Candida albicans. Acs Chemical Biology. 8: 2785-93. PMID 24083538 DOI: 10.1021/cb400607h  0.36
2013 Kittanakom S, Arnoldo A, Brown KR, Wallace I, Kunavisarut T, Torti D, Heisler LE, Surendra A, Moffat J, Giaever G, Nislow C. Miniature short hairpin rna screens to characterize antiproliferative drugs G3: Genes, Genomes, Genetics. 3: 1375-1387. PMID 23797109 DOI: 10.1534/g3.113.006437  0.36
2013 Torres NP, Lee AY, Giaever G, Nislow C, Brown GW. A high-throughput yeast assay identifies synergistic drug combinations. Assay and Drug Development Technologies. 11: 299-307. PMID 23772551 DOI: 10.1089/adt.2012.503  0.36
2013 Cheung-Ong K, Giaever G, Nislow C. DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology. Chemistry & Biology. 20: 648-59. PMID 23706631 DOI: 10.1016/j.chembiol.2013.04.007  0.36
2013 Srikumar T, Lewicki MC, Costanzo M, Tkach JM, van Bakel H, Tsui K, Johnson ES, Brown GW, Andrews BJ, Boone C, Giaever G, Nislow C, Raught B. Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. The Journal of Cell Biology. 201: 145-63. PMID 23547032 DOI: 10.1083/jcb.201210019  0.36
2013 Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, ... ... Giaever G, et al. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors Journal of Clinical Investigation. 123: 315-328. PMID 23202731 DOI: 10.1172/JCI64180  0.36
2012 Ammar R, Torti D, Tsui K, Gebbia M, Durbic T, Bader GD, Giaever G, Nislow C. Chromatin is an ancient innovation conserved between Archaea and Eukarya. Elife. 1: e00078. PMID 23240084 DOI: 10.7554/eLife.00078  0.36
2012 Alfred SE, Surendra A, Le C, Lin K, Mok A, Wallace IM, Proctor M, Urbanus ML, Giaever G, Nislow C. A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis. Genome Biology. 13: R105. PMID 23158586 DOI: 10.1186/gb-2012-13-11-r105  0.36
2012 Douglas AC, Smith AM, Sharifpoor S, Yan Z, Durbic T, Heisler LE, Lee AY, Ryan O, Göttert H, Surendra A, van Dyk D, Giaever G, Boone C, Nislow C, Andrews BJ. Functional analysis with a barcoder yeast gene overexpression system. G3 (Bethesda, Md.). 2: 1279-89. PMID 23050238 DOI: 10.1534/g3.112.003400  0.36
2012 Orij R, Urbanus ML, Vizeacoumar FJ, Giaever G, Boone C, Nislow C, Brul S, Smits GJ. Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae. Genome Biology. 13: R80. PMID 23021432 DOI: 10.1186/gb-2012-13-9-r80  0.36
2012 Shabtai D, Giaever G, Nislow C. An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations. Bmc Bioinformatics. 13: 245. PMID 23009392 DOI: 10.1186/1471-2105-13-245  0.36
2012 Ryan O, Shapiro RS, Kurat CF, Mayhew D, Baryshnikova A, Chin B, Lin ZY, Cox MJ, Vizeacoumar F, Cheung D, Bahr S, Tsui K, Tebbji F, Sellam A, Istel F, ... ... Giaever G, et al. Global gene deletion analysis exploring yeast filamentous growth. Science (New York, N.Y.). 337: 1353-6. PMID 22984072 DOI: 10.1126/science.1224339  0.36
2012 Cheung-Ong K, Song KT, Ma Z, Shabtai D, Lee AY, Gallo D, Heisler LE, Brown GW, Bierbach U, Giaever G, Nislow C. Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents. Acs Chemical Biology. 7: 1892-901. PMID 22928710 DOI: 10.1021/cb300320d  0.36
2012 Smith AM, Durbic T, Kittanakom S, Giaever G, Nislow C. Barcode sequencing for understanding drug-gene interactions. Methods in Molecular Biology (Clifton, N.J.). 910: 55-69. PMID 22821592 DOI: 10.1007/978-1-61779-965-5_4  0.36
2012 Singh-Babak SD, Shekhar T, Smith AM, Giaever G, Nislow C, Cowen LE. A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae. Molecular Biosystems. 8: 2575-84. PMID 22751784 DOI: 10.1039/c2mb25107h  0.36
2012 Jaime MD, Lopez-Llorca LV, Conesa A, Lee AY, Proctor M, Heisler LE, Gebbia M, Giaever G, Westwood JT, Nislow C. Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics. Bmc Genomics. 13: 267. PMID 22727066 DOI: 10.1186/1471-2164-13-267  0.36
2012 Blackman RK, Cheung-Ong K, Gebbia M, Proia DA, He S, Kepros J, Jonneaux A, Marchetti P, Kluza J, Rao PE, Wada Y, Giaever G, Nislow C. Mitochondrial electron transport is the cellular target of the oncology drug elesclomol. Plos One. 7: e29798. PMID 22253786 DOI: 10.1371/journal.pone.0029798  0.36
2012 Roemer T, Davies J, Giaever G, Nislow C. Bugs, drugs and chemical genomics. Nature Chemical Biology. 8: 46-56. PMID 22173359 DOI: 10.1038/nchembio.744  0.36
2011 Hoon S, Gebbia M, Costanzo M, Davis RW, Giaever G, Nislow C. A global perspective of the genetic basis for carbonyl stress resistance. G3 (Bethesda, Md.). 1: 219-31. PMID 22384333 DOI: 10.1534/g3.111.000505  0.36
2011 Berry DB, Guan Q, Hose J, Haroon S, Gebbia M, Heisler LE, Nislow C, Giaever G, Gasch AP. Multiple means to the same end: the genetic basis of acquired stress resistance in yeast. Plos Genetics. 7: e1002353. PMID 22102822 DOI: 10.1371/journal.pgen.1002353  0.36
2011 Skrti? M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, ... ... Giaever G, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 20: 674-88. PMID 22094260 DOI: 10.1016/j.ccr.2011.10.015  0.36
2011 Cokol M, Chua HN, Tasan M, Mutlu B, Weinstein ZB, Suzuki Y, Nergiz ME, Costanzo M, Baryshnikova A, Giaever G, Nislow C, Myers CL, Andrews BJ, Boone C, Roth FP. Systematic exploration of synergistic drug pairs. Molecular Systems Biology. 7: 544. PMID 22068327 DOI: 10.1038/msb.2011.71  0.36
2011 Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nature Chemical Biology. 7: 891-3. PMID 22057127 DOI: 10.1038/nchembio.698  0.36
2011 Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, ... Giaever G, et al. Compound prioritization methods increase rates of chemical probe discovery in model organisms. Chemistry & Biology. 18: 1273-83. PMID 22035796 DOI: 10.1016/j.chembiol.2011.07.018  0.36
2011 Lissina E, Young B, Urbanus ML, Guan XL, Lowenson J, Hoon S, Baryshnikova A, Riezman I, Michaut M, Riezman H, Cowen LE, Wenk MR, Clarke SG, Giaever G, Nislow C. A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. Plos Genetics. 7: e1002332. PMID 22028670 DOI: 10.1371/journal.pgen.1002332  0.36
2011 Minear S, O'Donnell AF, Ballew A, Giaever G, Nislow C, Stearns T, Cyert MS. Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation. Eukaryotic Cell. 10: 1574-81. PMID 21908599 DOI: 10.1128/EC.05163-11  0.36
2011 Wallace IM, Bader GD, Giaever G, Nislow C. Displaying chemical information on a biological network using Cytoscape. Methods in Molecular Biology (Clifton, N.J.). 781: 363-76. PMID 21877291 DOI: 10.1007/978-1-61779-276-2_18  0.36
2011 Proctor M, Urbanus ML, Fung EL, Jaramillo DF, Davis RW, Nislow C, Giaever G. The automated cell: compound and environment screening system (ACCESS) for chemogenomic screening. Methods in Molecular Biology (Clifton, N.J.). 759: 239-69. PMID 21863492 DOI: 10.1007/978-1-61779-173-4_15  0.36
2011 Smith AM, Durbic T, Oh J, Urbanus M, Proctor M, Heisler LE, Giaever G, Nislow C. Competitive genomic screens of barcoded yeast libraries. Journal of Visualized Experiments : Jove. PMID 21860376 DOI: 10.3791/2864  0.36
2011 Bendaha H, Yu L, Touzani R, Souane R, Giaever G, Nislow C, Boone C, El Kadiri S, Brown GW, Bellaoui M. New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole. European Journal of Medicinal Chemistry. 46: 4117-24. PMID 21723647 DOI: 10.1016/j.ejmech.2011.06.012  0.36
2011 Klein M, Morillas M, Vendrell A, Brive L, Gebbia M, Wallace IM, Giaever G, Nislow C, Posas F, Grøtli M. Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. Plos One. 6: e20789. PMID 21698101 DOI: 10.1371/journal.pone.0020789  0.36
2011 Dinér P, Veide Vilg J, Kjellén J, Migdal I, Andersson T, Gebbia M, Giaever G, Nislow C, Hohmann S, Wysocki R, Tamás MJ, Grøtli M. Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast. Plos One. 6: e20012. PMID 21655328 DOI: 10.1371/journal.pone.0020012  0.36
2011 Magtanong L, Ho CH, Barker SL, Jiao W, Baryshnikova A, Bahr S, Smith AM, Heisler LE, Choy JS, Kuzmin E, Andrusiak K, Kobylianski A, Li Z, Costanzo M, Basrai MA, ... Giaever G, et al. Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Nature Biotechnology. 29: 505-11. PMID 21572441 DOI: 10.1038/nbt.1855  0.36
2011 Ketela T, Heisler LE, Brown KR, Ammar R, Kasimer D, Surendra A, Ericson E, Blakely K, Karamboulas D, Smith AM, Durbic T, Arnoldo A, Cheung-Ong K, Koh JL, Gopal S, ... ... Giaever G, et al. A comprehensive platform for highly multiplexed mammalian functional genetic screens. Bmc Genomics. 12: 213. PMID 21548937 DOI: 10.1186/1471-2164-12-213  0.36
2011 Tamble CM, St. Onge RP, Giaever G, Nislow C, Williams AG, Stuart JM, Lokey RS. The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae Molecular Biosystems. 7: 2019-2030. PMID 21487606 DOI: 10.1039/c0mb00298d  0.36
2011 Li Z, Vizeacoumar FJ, Bahr S, Li J, Warringer J, Vizeacoumar FS, Min R, Vandersluis B, Bellay J, Devit M, Fleming JA, Stephens A, Haase J, Lin ZY, Baryshnikova A, ... ... Giaever G, et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nature Biotechnology. 29: 361-7. PMID 21441928 DOI: 10.1038/nbt.1832  0.36
2011 Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, et al. Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nature Methods. 8: 159-64. PMID 21217751 DOI: 10.1038/nmeth.1550  0.36
2010 Oh J, Fung E, Schlecht U, Davis RW, Giaever G, St Onge RP, Deutschbauer A, Nislow C. Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection. Plos Pathogens. 6: e1001140. PMID 20949076 DOI: 10.1371/journal.ppat.1001140  0.36
2010 Ericson E, Hoon S, St Onge RP, Giaever G, Nislow C. Exploring gene function and drug action using chemogenomic dosage assays. Methods in Enzymology. 470: 233-55. PMID 20946813 DOI: 10.1016/S0076-6879(10)70010-0  0.36
2010 Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD. Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. Plos Genetics. 6: e1001024. PMID 20657825 DOI: 10.1371/journal.pgen.1001024  0.36
2010 Smith AM, Ammar R, Nislow C, Giaever G. A survey of yeast genomic assays for drug and target discovery. Pharmacology & Therapeutics. 127: 156-64. PMID 20546776 DOI: 10.1016/j.pharmthera.2010.04.012  0.36
2010 Burns AR, Wallace IM, Wildenhain J, Tyers M, Giaever G, Bader GD, Nislow C, Cutler SR, Roy PJ. A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans. Nature Chemical Biology. 6: 549-57. PMID 20512140 DOI: 10.1038/nchembio.380  0.36
2010 Oh J, Fung E, Price MN, Dehal PS, Davis RW, Giaever G, Nislow C, Arkin AP, Deutschbauer A. A universal TagModule collection for parallel genetic analysis of microorganisms. Nucleic Acids Research. 38: e146. PMID 20494978 DOI: 10.1093/nar/gkq419  0.36
2010 Smith AM, Heisler LE, St.Onge RP, Farias-Hesson E, Wallace IM, Bodeau J, Harris AN, Perry KM, Giaever G, Pourmand N, Nislow C. Highly-multiplexed barcode sequencing: An efficient method for parallel analysis of pooled samples Nucleic Acids Research. 38: e142-e142. PMID 20460461 DOI: 10.1093/nar/gkq368  0.36
2010 Dowell RD, Ryan O, Jansen A, Cheung D, Agarwala S, Danford T, Bernstein DA, Rolfe PA, Heisler LE, Chin B, Nislow C, Giaever G, Phillips PC, Fink GR, Gifford DK, et al. Genotype to phenotype: a complex problem. Science (New York, N.Y.). 328: 469. PMID 20413493 DOI: 10.1126/science.1189015  0.36
2010 Hillenmeyer ME, Ericson E, Davis RW, Nislow C, Koller D, Giaever G. Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action. Genome Biology. 11: R30. PMID 20226027 DOI: 10.1186/gb-2010-11-3-r30  0.36
2010 Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, ... ... Giaever G, et al. The genetic landscape of a cell. Science (New York, N.Y.). 327: 425-31. PMID 20093466 DOI: 10.1126/science.1180823  0.36
2009 Ammar R, Smith AM, Heisler LE, Giaever G, Nislow C. A comparative analysis of DNA barcode microarray feature size Bmc Genomics. 10: 471. PMID 19825181 DOI: 10.1186/1471-2164-10-471  0.36
2009 Smith AM, Heisler LE, Mellor J, Kaper F, Thompson MJ, Chee M, Roth FP, Giaever G, Nislow C. Quantitative phenotyping via deep barcode sequencing. Genome Research. 19: 1836-42. PMID 19622793 DOI: 10.1101/gr.093955.109  0.36
2009 Pierce SE, Davis RW, Nislow C, Giaever G. Chemogenomic approaches to elucidation of gene function and genetic pathways. Methods in Molecular Biology (Clifton, N.J.). 548: 115-43. PMID 19521822 DOI: 10.1007/978-1-59745-540-4_7  0.36
2009 Ho CH, Magtanong L, Barker SL, Gresham D, Nishimura S, Natarajan P, Koh JL, Porter J, Gray CA, Andersen RJ, Giaever G, Nislow C, Andrews B, Botstein D, Graham TR, et al. A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nature Biotechnology. 27: 369-77. PMID 19349972 DOI: 10.1038/nbt.1534  0.36
2009 Yan Z, Berbenetz NM, Giaever G, Nislow C. Precise gene-dose alleles for chemical genetics. Genetics. 182: 623-6. PMID 19332878 DOI: 10.1534/genetics.109.103036  0.36
2009 Jo WJ, Kim JH, Oh E, Jaramillo D, Holman P, Loguinov AV, Arkin AP, Nislow C, Giaever G, Vulpe CD. Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae. Bmc Genomics. 10: 130. PMID 19321002 DOI: 10.1186/1471-2164-10-130  0.36
2009 Hess DC, Myers CL, Huttenhower C, Hibbs MA, Hayes AP, Paw J, Clore JJ, Mendoza RM, Luis BS, Nislow C, Giaever G, Costanzo M, Troyanskaya OG, Caudy AA. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Plos Genetics. 5: e1000407. PMID 19300474 DOI: 10.1371/journal.pgen.1000407  0.36
2009 Giaever G, Nislow C. Knocking sense into regulatory pathways. Nature Biotechnology. 27: 149-50. PMID 19204694 DOI: 10.1038/nbt0209-149  0.36
2009 Kemmer D, McHardy LM, Hoon S, Rebérioux D, Giaever G, Nislow C, Roskelley CD, Roberge M. Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis. Bmc Microbiology. 9: 9. PMID 19144191 DOI: 10.1186/1471-2180-9-9  0.36
2008 Yu L, Lopez A, Anaflous A, El Bali B, Hamal A, Ericson E, Heisler LE, McQuibban A, Giaever G, Nislow C, Boone C, Brown GW, Bellaoui M. Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. Plos Genetics. 4: e1000284. PMID 19043571 DOI: 10.1371/journal.pgen.1000284  0.36
2008 Lehár J, Stockwell BR, Giaever G, Nislow C. Combination chemical genetics. Nature Chemical Biology. 4: 674-81. PMID 18936752 DOI: 10.1038/nchembio.120  0.36
2008 Hoon S, St Onge RP, Giaever G, Nislow C. Yeast chemical genomics and drug discovery: an update. Trends in Pharmacological Sciences. 29: 499-504. PMID 18755517 DOI: 10.1016/j.tips.2008.07.006  0.36
2008 Ericson E, Gebbia M, Heisler LE, Wildenhain J, Tyers M, Giaever G, Nislow C. Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast Plos Genetics. 4. PMID 18688276 DOI: 10.1371/journal.pgen.1000151  0.36
2008 Yan Z, Costanzo M, Heisler LE, Paw J, Kaper F, Andrews BJ, Boone C, Giaever G, Nislow C. Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nature Methods. 5: 719-25. PMID 18622398 DOI: 10.1038/nmeth.1231  0.36
2008 Hoon S, Smith AM, Wallace IM, Suresh S, Miranda M, Fung E, Proctor M, Shokat KM, Zhang C, Davis RW, Giaever G, St Onge RP, StOnge RP, Nislow C. An integrated platform of genomic assays reveals small-molecule bioactivities. Nature Chemical Biology. 4: 498-506. PMID 18622389 DOI: 10.1038/nchembio.100  0.36
2008 Musso G, Costanzo M, Huangfu M, Smith AM, Paw J, San Luis BJ, Boone C, Giaever G, Nislow C, Emili A, Zhang Z. The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome Research. 18: 1092-9. PMID 18463300 DOI: 10.1101/gr.076174.108  0.36
2008 Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A, Giaever G, Nislow C, Merrill AR, Merrill RA, Lory S, et al. Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. Plos Genetics. 4: e1000005. PMID 18454192 DOI: 10.1371/journal.pgen.1000005  0.36
2008 Hillenmeyer ME, Fung E, Wildenhain J, Pierce SE, Hoon S, Lee W, Proctor M, St Onge RP, Tyers M, Koller D, Altman RB, Davis RW, Nislow C, Giaever G. The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science (New York, N.Y.). 320: 362-5. PMID 18420932 DOI: 10.1126/science.1150021  0.36
2008 Lopez A, Parsons AB, Nislow C, Giaever G, Boone C. Chemical-genetic approaches for exploring the mode of action of natural products. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 66: 237, 239-71. PMID 18416308  0.36
2008 Jo WJ, Loguinov A, Chang M, Wintz H, Nislow C, Arkin AP, Giaever G, Vulpe CD. Identification of genes involved in the toxic response of saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants Toxicological Sciences. 101: 140-151. PMID 17785683 DOI: 10.1093/toxsci/kfm226  0.36
2007 Pierce SE, Davis RW, Nislow C, Giaever G. Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures. Nature Protocols. 2: 2958-2974. PMID 18007632 DOI: 10.1038/nprot.2007.427  0.36
2007 Suter B, Fetchko MJ, Imhof R, Graham CI, Stoffel-Studer I, Zbinden C, Raghavan M, Lopez L, Beneti L, Hort J, Fillingham J, Greenblatt JF, Giaever G, Nislow C, Stagljar I. Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system. Genome Research. 17: 1774-82. PMID 17989249 DOI: 10.1101/gr.6667007  0.36
2007 Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St. Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS. Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay Journal of Natural Products. 70: 383-390. PMID 17291044 DOI: 10.1021/np060555t  0.36
2007 St Onge RP, Mani R, Oh J, Proctor M, Fung E, Davis RW, Nislow C, Roth FP, Giaever G. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nature Genetics. 39: 199-206. PMID 17206143 DOI: 10.1038/ng1948  0.36
2007 Doostzadeh J, Davis RW, Giaever GN, Nislow C, Langston JW. Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 95: 182-7. PMID 17043098 DOI: 10.1093/toxsci/kfl131  0.36
2006 Costanzo M, Giaever G, Nislow C, Andrews B. Experimental approaches to identify genetic networks. Current Opinion in Biotechnology. 17: 472-80. PMID 16962766 DOI: 10.1016/j.copbio.2006.08.005  0.36
2006 Pierce SE, Fung EL, Jaramillo DF, Chu AM, Davis RW, Nislow C, Giaever G. A unique and universal molecular barcode array. Nature Methods. 3: 601-3. PMID 16862133 DOI: 10.1038/nmeth905  0.36
2005 Lee W, St Onge RP, Proctor M, Flaherty P, Jordan MI, Arkin AP, Davis RW, Nislow C, Giaever G. Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. Plos Genetics. 1: e24. PMID 16121259 DOI: 10.1371/journal.pgen.0010024  0.36
2005 Deutschbauer AM, Jaramillo DF, Proctor M, Kumm J, Hillenmeyer ME, Davis RW, Nislow C, Giaever G. Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics. 169: 1915-25. PMID 15716499 DOI: 10.1534/genetics.104.036871  0.36
2004 Giaever G, Flaherty P, Kumm J, Proctor M, Nislow C, Jaramillo DF, Chu AM, Jordan MI, Arkin AP, Davis RW. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proceedings of the National Academy of Sciences of the United States of America. 101: 793-8. PMID 14718668 DOI: 10.1073/pnas.0307490100  0.36
2003 Nislow C, Giaever G. "Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration". Pharmacogenomics. 4: 15-8. PMID 12517281 DOI: 10.1517/phgs.4.1.15.22579  0.36
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