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Kenneth M. Pfarr, Ph.D. - Publications

Affiliations: 
2001 Tufts University, Boston 
Area:
General Biology
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Njouendou AJ, Ritter M, Kien CA, Esum ME, Ndongmo WPC, Fombad FF, Gandjui NVT, Njiokou F, Enyong P, Pfarr K, Turner J, Layland LE, Hoerauf A, Wanji S. Dataset on maintenance of microfilariae and drug testing. Data in Brief. 28: 104930. PMID 31886361 DOI: 10.1016/J.Dib.2019.104930  0.315
2019 Njouendou AJ, Kien CA, Esum ME, Ritter M, Chounna Ndongmo WP, Fombad FF, Gandjui NVT, Njiokou F, Enyong P, Pfarr K, Turner J, Layland LE, Hoerauf A, Wanji S. In vitro maintenance of Mansonella perstans microfilariae and its relevance for drug screening. Experimental Parasitology. 107769. PMID 31580876 DOI: 10.1016/J.Exppara.2019.107769  0.352
2019 Hübner MP, Koschel M, Struever D, Nikolov V, Frohberger SJ, Ehrens A, Fendler M, Johannes I, von Geldern TW, Marsh K, Turner JD, Taylor MJ, Ward SA, Pfarr K, Kempf DJ, et al. In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae. Plos Neglected Tropical Diseases. 13: e0007636. PMID 31381563 DOI: 10.1371/Journal.Pntd.0007636  0.322
2019 Batsa Debrah L, Phillips RO, Pfarr K, Klarmann-Schulz U, Opoku VS, Nausch N, Owusu W, Mubarik Y, Sander AL, Lämmer C, Ritter M, Layland LE, Jacobsen M, Debrah AY, Hoerauf A. The Efficacy of Doxycycline Treatment on Infection: An Open-Label, Randomized Trial in Ghana. The American Journal of Tropical Medicine and Hygiene. PMID 31162017 DOI: 10.4269/Ajtmh.18-0491  0.315
2019 Loeper N, Graspeuntner S, Ledig S, Kaufhold I, Hoellen F, Schiefer A, Henrichfreise B, Pfarr K, Hoerauf A, Shima K, Rupp J. Elaborations on Corallopyronin A as a Novel Treatment Strategy Against Genital Chlamydial Infections. Frontiers in Microbiology. 10: 943. PMID 31134007 DOI: 10.3389/Fmicb.2019.00943  0.315
2019 Ritter M, Osei-Mensah J, Debrah LB, Kwarteng A, Mubarik Y, Debrah AY, Pfarr K, Hoerauf A, Layland LE. Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment. Plos Neglected Tropical Diseases. 13. PMID 31120872 DOI: 10.1371/Journal.Pntd.0007436  0.319
2019 Coghlan A, Tyagi R, Cotton JA, Holroyd N, Rosa BA, Tsai IJ, Laetsch DR, Beech RN, Day TA, Hallsworth-Pepin K, Ke H, Kuo T, Lee TJ, Martin J, Maizels RM, ... ... Pfarr K, et al. Comparative genomics of the major parasitic worms Nature Genetics. 51: 163-174. PMID 30397333 DOI: 10.1038/S41588-018-0262-1  0.32
2018 Mukherjee S, Joardar N, Mondal S, Schiefer A, Hoerauf A, Pfarr K, Babu SPS. Quinolone-fused cyclic sulfonamide as a novel benign antifilarial agent. Scientific Reports. 8: 12073. PMID 30104608 DOI: 10.1038/S41598-018-30610-7  0.346
2018 Hendy A, Krüger A, Pfarr K, De Witte J, Kibweja A, Mwingira U, Dujardin JC, Post R, Colebunders R, O'Neill S, Kalinga A. The blackfly vectors and transmission of Onchocerca volvulus in Mahenge, south eastern Tanzania. Acta Tropica. PMID 29410302 DOI: 10.1016/J.Actatropica.2018.01.009  0.334
2018 Kock F, Hauptmann M, Osterloh A, Schäberle TF, Poppert S, Frickmann H, Menzel KD, Peschel G, Pfarr K, Schiefer A, König GM, Hoerauf A, Fleischer B, Keller C. Orientia tsutsugamushi is highly susceptible to the RNA polymerase switch region inhibitor Corallopyronin A in vitro and in vivo. Antimicrobial Agents and Chemotherapy. PMID 29358295 DOI: 10.1128/Aac.01732-17  0.335
2018 Specht S, Pfarr KM, Arriens S, Hübner MP, Klarmann-Schulz U, Koschel M, Sternberg S, Martin C, Ford L, Taylor MJ, Hoerauf A. Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model. Plos Neglected Tropical Diseases. 12: e0006116. PMID 29300732 DOI: 10.1371/Journal.Pntd.0006116  0.325
2017 Wewer V, Makepeace BL, Tanya VN, Peisker H, Pfarr K, Hoerauf A, Dörmann P. Lipid profiling of the filarial nematodes Onchocerca volvulus, Onchocerca ochengi and Litomosoides sigmodontis reveals the accumulation of nematode-specific ether phospholipids in the host International Journal For Parasitology. 47: 903-912. PMID 28743489 DOI: 10.1016/J.Ijpara.2017.06.001  0.336
2017 Globisch D, Eubanks LM, Shirey RJ, Pfarr KM, Wanji S, Debrah AY, Hoerauf A, Janda KD. Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG). Bioorganic & Medicinal Chemistry Letters. PMID 28600214 DOI: 10.1016/J.Bmcl.2017.05.082  0.33
2016 Ajendra J, Specht S, Ziewer S, Schiefer A, Pfarr K, Parčina M, Kufer TA, Hoerauf A, Hübner MP. NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae. Scientific Reports. 6: 39648. PMID 28004792 DOI: 10.1038/Srep39648  0.343
2016 Elfaki TEM, Arndts K, Wiszniewsky A, Ritter M, Goreish IA, Mekki MEYAAE, Arriens S, Pfarr K, Fimmers R, Doenhoff M, Hoerauf A, Layland LE. Multivariable Regression Analysis in Schistosoma mansoni-Infected Individuals in the Sudan Reveals Unique Immunoepidemiological Profiles in Uninfected, egg+ and Non-egg+ Infected Individuals. Plos Neglected Tropical Diseases. 10. PMID 27152725 DOI: 10.1371/Journal.Pntd.0004629  0.321
2015 Globisch D, Specht S, Pfarr KM, Eubanks LM, Hoerauf A, Janda KD. Litomosoides sigmodontis: A jird urine metabolome study. Bioorganic & Medicinal Chemistry Letters. 25: 5804-7. PMID 26573416 DOI: 10.1016/J.Bmcl.2015.10.037  0.365
2015 Lentz CS, Sattler JM, Fendler M, Gottwalt S, Halls VS, Strassel S, Arriens S, Hannam JS, Specht S, Famulok M, Mueller AK, Hoerauf A, Pfarr KM. In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites. Antimicrobial Agents and Chemotherapy. 59: 654-8. PMID 25313210 DOI: 10.1128/Aac.02383-14  0.316
2014 Johnston KL, Ford L, Umareddy I, Townson S, Specht S, Pfarr K, Hoerauf A, Altmeyer R, Taylor MJ. Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis. International Journal For Parasitology. Drugs and Drug Resistance. 4: 278-86. PMID 25516838 DOI: 10.1016/J.Ijpddr.2014.09.001  0.306
2014 Albers A, Sartono E, Wahyuni S, Yazdanbakhsh M, Maizels RM, Klarmann-Schulz U, Pfarr K, Hoerauf A. Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent Brugia malayi Infections: a study in Indonesian transmigrants. Parasites & Vectors. 7: 146. PMID 24685183 DOI: 10.1186/1756-3305-7-146  0.328
2014 Arumugam S, Hoerauf A, Pfarr KM. Localization of a filarial phosphate permease that is up-regulated in response to depletion of essential Wolbachia endobacteria. Experimental Parasitology. 138: 30-9. PMID 24480589 DOI: 10.1016/J.Exppara.2014.01.006  0.337
2014 Schäberle TF, Schiefer A, Schmitz A, König GM, Hoerauf A, Pfarr K. Corallopyronin A – A promising antibiotic for treatment of filariasis International Journal of Medical Microbiology. 304: 72-78. PMID 24079981 DOI: 10.1016/J.Ijmm.2013.08.010  0.304
2013 Schiefer A, Vollmer J, Lämmer C, Specht S, Lentz C, Ruebsamen-Schaeff H, Brötz-Oesterhelt H, Hoerauf A, Pfarr K. The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections. The Journal of Antimicrobial Chemotherapy. 68: 1790-800. PMID 23584755 DOI: 10.1093/Jac/Dkt105  0.32
2013 Lentz CS, Halls V, Hannam JS, Niebel B, Strübing U, Mayer G, Hoerauf A, Famulok M, Pfarr KM. A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro. Chemistry & Biology. 20: 177-87. PMID 23438747 DOI: 10.1016/J.Chembiol.2012.11.009  0.321
2012 Schiefer A, Schmitz A, Schäberle TF, Specht S, Lämmer C, Johnston KL, Vassylyev DG, König GM, Hoerauf A, Pfarr K. Corallopyronin a specifically targets and depletes essential obligate wolbachia endobacteria from filarial nematodes in vivo Journal of Infectious Diseases. 206: 249-257. PMID 22586066 DOI: 10.1093/Infdis/Jis341  0.314
2012 Albers A, Esum ME, Tendongfor N, Enyong P, Klarmann U, Wanji S, Hoerauf A, Pfarr K. Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host. Parasites & Vectors. 5: 12. PMID 22236497 DOI: 10.1186/1756-3305-5-12  0.343
2011 Debrah AY, Batsa L, Albers A, Mand S, Toliat MR, Nürnberg P, Adjei O, Hoerauf A, Pfarr K. Transforming growth factor-β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis. Human Immunology. 72: 1143-1148. PMID 21843572 DOI: 10.1016/J.Humimm.2011.07.305  0.316
2011 Hoerauf A, Pfarr K, Mand S, Debrah AY, Specht S. Filariasis in Africa--treatment challenges and prospects. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. 17: 977-85. PMID 21722251 DOI: 10.1111/J.1469-0691.2011.03586.X  0.352
2011 Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Albers A, Specht S, Klarmann U, Pfarr K, Adjei O, Hoerauf A. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline. Journal of Parasitology Research. 2011: 201617. PMID 21687646 DOI: 10.1155/2011/201617  0.34
2009 Pfarr KM, Debrah AY, Specht S, Hoerauf A. Filariasis and lymphoedema Parasite Immunology. 31: 664-672. PMID 19825106 DOI: 10.1111/J.1365-3024.2009.01133.X  0.306
2008 Arumugam S, Pfarr KM, Hoerauf A. Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms. International Journal For Parasitology. 38: 981-7. PMID 18282572 DOI: 10.1016/J.Ijpara.2007.12.006  0.355
2008 Hoerauf A, Specht S, Büttner M, Pfarr K, Mand S, Fimmers R, Marfo-Debrekyei Y, Konadu P, Debrah AY, Bandi C, Brattig N, Albers A, Larbi J, Batsa L, Taylor MJ, et al. Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study Medical Microbiology and Immunology. 197: 295-311. PMID 17999080 DOI: 10.1007/S00430-007-0062-1  0.325
2007 Pfarr KM, Hoerauf A. A niche for Wolbachia. Trends in Parasitology. 23: 5-7. PMID 17113827 DOI: 10.1016/J.Pt.2006.11.002  0.324
2006 Debrah AY, Mand S, Specht S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Larbi J, Lawson B, Taylor M, Adjei O, Hoerauf A. Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis. Plos Pathogens. 2: e92. PMID 17044733 DOI: 10.1371/Journal.Ppat.0020092  0.305
2006 Heider U, Blaxter M, Hoerauf A, Pfarr KM. Differential display of genes expressed in the filarial nematode Litomosoides sigmodontis reveals a putative phosphate permease up-regulated after depletion of Wolbachia endobacteria. International Journal of Medical Microbiology : Ijmm. 296: 287-99. PMID 16616613 DOI: 10.1016/J.Ijmm.2005.12.019  0.347
2005 Gilbert J, Nfon CK, Makepeace BL, Njongmeta LM, Hastings IM, Pfarr KM, Renz A, Tanya VN, Trees AJ. Antibiotic chemotherapy of onchocerciasis: in a bovine model, killing of adult parasites requires a sustained depletion of endosymbiotic bacteria (Wolbachia species). The Journal of Infectious Diseases. 192: 1483-93. PMID 16170768 DOI: 10.1086/462426  0.356
2003 Hoerauf A, Mand S, Fischer K, Kruppa T, Marfo-Debrekyei Y, Debrah AY, Pfarr KM, Adjei O, Büttner DW. Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Medical Microbiology and Immunology. 192: 211-6. PMID 12684759 DOI: 10.1007/S00430-002-0174-6  0.315
2003 McGarry HF, Pfarr K, Egerton G, Hoerauf A, Akue JP, Enyong P, Wanji S, Kläger SL, Bianco AE, Beeching NJ, Taylor MJ. Evidence against Wolbachia symbiosis in Loa loa Filaria Journal. 2. DOI: 10.1186/1475-2883-2-9  0.332
2001 Pfarr KM, Qazi S, Fuhrman JA. Nitric oxide synthase in filariae: demonstration of nitric oxide production by embryos in Brugia malayi and Acanthocheilonema viteae. Experimental Parasitology. 97: 205-14. PMID 11384164 DOI: 10.1006/Expr.2001.4613  0.674
2000 Pfarr KM, Fuhrman JA. Brugia malayi: localization of nitric oxide synthase in a lymphatic filariid. Experimental Parasitology. 94: 92-8. PMID 10673345 DOI: 10.1006/Expr.1999.4474  0.661
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