Rajesh Ambasudhan - Publications

Scripps Research Institute, La Jolla, La Jolla, CA, United States 

28/33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lee M, Kim J, Ambasudhan R. Direct Reprogramming of Human Fibroblasts into Induced Neural Progenitor Cells Using Suicide Gene Embodied Episomal Vectors for Rapid Selection of Exogenous DNA-Free Cells. Methods in Molecular Biology (Clifton, N.J.). 2239: 61-75. PMID 33226613 DOI: 10.1007/978-1-0716-1084-8_5  0.4
2020 Ghatak S, Dolatabadi N, Gao R, Wu Y, Scott H, Trudler D, Sultan A, Ambasudhan R, Nakamura T, Masliah E, Talantova M, Voytek B, Lipton SA. NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models. Molecular Psychiatry. PMID 32467645 DOI: 10.1038/s41380-020-0776-7  0.56
2019 Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA. Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control. Elife. 8. PMID 31782729 DOI: 10.7554/eLife.50333  0.56
2018 Mann AP, Scodeller P, Hussain S, Braun GB, Mölder T, Toome K, Ambasudhan R, Teesalu T, Lipton SA, Ruoslahti E. Publisher Correction: Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nature Communications. 9: 1070. PMID 29523838 DOI: 10.1038/s41467-018-03517-0  0.56
2018 Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD. Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nature Communications. 9: 817. PMID 29483518 DOI: 10.1038/s41467-018-03241-9  0.56
2017 Oh CK, Sultan A, Platzer J, Dolatabadi N, Soldner F, McClatchy DB, Diedrich JK, Yates JR, Ambasudhan R, Nakamura T, Jaenisch R, Lipton SA. S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models. Cell Reports. 21: 2171-2182. PMID 29166608 DOI: 10.1016/j.celrep.2017.10.068  0.56
2017 Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, ... ... Ambasudhan R, et al. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nature Communications. 8: 1488. PMID 29133852 DOI: 10.1038/s41467-017-01563-8  0.56
2017 Mann AP, Scodeller P, Hussain S, Braun GB, Mölder T, Toome K, Ambasudhan R, Teesalu T, Lipton SA, Ruoslahti E. Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nature Communications. 8: 1403. PMID 29123083 DOI: 10.1038/s41467-017-01096-0  0.56
2016 Sunico CR, Sultan A, Nakamura T, Dolatabadi N, Parker J, Shan B, Han X, Yates JR, Masliah E, Ambasudhan R, Nakanishi N, Lipton SA. Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821734 DOI: 10.1073/pnas.1608784113  0.56
2016 Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WM, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. Hydrogen Sulfide-Mechanisms of Toxicity and Development of an Antidote. Scientific Reports. 6: 20831. PMID 26877209 DOI: 10.1038/srep20831  0.64
2016 Akhtar MW, Sanz-Blasco S, Dolatabadi N, Parker J, Chon K, Lee MS, Soussou W, McKercher SR, Ambasudhan R, Nakamura T, Lipton SA. Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nature Communications. 7: 10242. PMID 26743041 DOI: 10.1038/ncomms10242  0.64
2015 Nakamura T, Prikhodko OA, Pirie E, Nagar S, Akhtar MW, Oh CK, McKercher SR, Ambasudhan R, Okamoto SI, Lipton SA. Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases. Neurobiology of Disease. PMID 25796565 DOI: 10.1016/j.nbd.2015.03.017  0.64
2015 Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. Journal of Neurochemistry. 133: 898-908. PMID 25692407 DOI: 10.1111/jnc.13074  0.64
2015 Okamoto SI, Ambasudhan R, Nakamura T, Lipton SA. S-Nitrosylation of MEF2: A common mechanism underlying neurological disorders? Future Neurology. 10: 1-5. DOI: 10.2217/fnl.14.59  0.64
2014 Ambasudhan R, Dolatabadi N, Nutter A, Masliah E, Mckercher SR, Lipton SA. Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells. The Journal of Comparative Neurology. 522: 2845-56. PMID 24756727 DOI: 10.1002/cne.23617  0.64
2014 Zhu S, Ambasudhan R, Sun W, Kim HJ, Talantova M, Wang X, Zhang M, Zhang Y, Laurent T, Parker J, Kim HS, Zaremba JD, Saleem S, Sanz-Blasco S, Masliah E, et al. Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Research. 24: 126-9. PMID 24296783 DOI: 10.1038/cr.2013.156  0.64
2013 Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, ... ... Ambasudhan R, et al. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. Cell. 155: 1351-64. PMID 24290359 DOI: 10.1016/j.cell.2013.11.009  0.64
2013 Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Ambasudhan R, et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America. 110: E2518-27. PMID 23776240 DOI: 10.1073/pnas.1306832110  0.64
2012 Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, Lipton SA. High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15837-42. PMID 23136422 DOI: 10.1523/JNEUROSCI.3735-12.2012  0.64
2012 Kim J, Ambasudhan R, Ding S. Direct lineage reprogramming to neural cells. Current Opinion in Neurobiology. 22: 778-84. PMID 22652035 DOI: 10.1016/j.conb.2012.05.001  0.64
2011 Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton SA, Ding S. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell. 9: 113-8. PMID 21802386 DOI: 10.1016/j.stem.2011.07.002  0.64
2011 Li W, Sun W, Zhang Y, Wei W, Ambasudhan R, Xia P, Talantova M, Lin T, Kim J, Wang X, Kim WR, Lipton SA, Zhang K, Ding S. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 8299-304. PMID 21525408 DOI: 10.1073/pnas.1014041108  0.64
2010 Zhu S, Li W, Zhou H, Wei W, Ambasudhan R, Lin T, Kim J, Zhang K, Ding S. Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell. 7: 651-5. PMID 21112560 DOI: 10.1016/j.stem.2010.11.015  0.64
2009 Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S. A chemical platform for improved induction of human iPSCs. Nature Methods. 6: 805-8. PMID 19838168 DOI: 10.1038/nmeth.1393  0.64
2007 Ambasudhan R, Ding S. An "Orphan" Finds a Home in NSC Regulation Chemistry and Biology. 14: 974-975. PMID 17884628 DOI: 10.1016/j.chembiol.2007.09.001  0.64
2004 Ambasudhan R, Wang X, Jablonski MM, Thompson DA, Lagali PS, Wong PW, Sieving PA, Ayyagari R. Atrophic macular degeneration mutations in ELOVL4 result in the intracellular misrouting of the protein. Genomics. 83: 615-25. PMID 15028284 DOI: 10.1016/j.ygeno.2003.10.004  0.64
2003 Khani SC, Karoukis AJ, Young JE, Ambasudhan R, Burch T, Stockton R, Lewis RA, Sullivan LS, Daiger SP, Reichel E, Ayyagari R. Late-onset autosomal dominant macular dystrophy with choroidal neovascularization and nonexudative maculopathy associated with mutation in the RDS gene. Investigative Ophthalmology & Visual Science. 44: 3570-7. PMID 12882809 DOI: 10.1167/iovs.02-1287  0.64
2003 Lagali PS, Liu J, Ambasudhan R, Kakuk LE, Bernstein SL, Seigel GM, Wong PW, Ayyagari R. Evolutionarily conserved ELOVL4 gene expression in the vertebrate retina. Investigative Ophthalmology & Visual Science. 44: 2841-50. PMID 12824221 DOI: 10.1167/iovs.02-0991  0.64
Low-probability matches
2005 Umeda S, Ayyagari R, Allikmets R, Suzuki MT, Karoukis AJ, Ambasudhan R, Zernant J, Okamoto H, Ono F, Terao K, Mizota A, Yoshikawa Y, Tanaka Y, Iwata T. Early-onset macular degeneration with drusen in a cynomolgus monkey (Macaca fascicularis) pedigree: exclusion of 13 candidate genes and loci. Investigative Ophthalmology & Visual Science. 46: 683-91. PMID 15671300 DOI: 10.1167/iovs.04-1031  0.16
2004 Mandal MN, Ambasudhan R, Wong PW, Gage PJ, Sieving PA, Ayyagari R. Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression. Genomics. 83: 626-35. PMID 15028285 DOI: 10.1016/j.ygeno.2003.09.020  0.16
2018 Ghatak S, Trudler D, Dolatabadi N, Ambasudhan R. Parkinson's disease: what the model systems have taught us so far. Journal of Genetics. 97: 729-751. PMID 30027906  0.12
2013 Ainza CA, Le T, Parker J, Ambasudhan R, Nakayama T, Naviaux RK, Lipton SA, Chen HV, Haas RH. Generation of patient-specific differentiated cells from fibroblast-derived hiPSCs for studying treatment of mitochondrial disease Mitochondrion. 13: 931-932. DOI: 10.1016/j.mito.2013.07.086  0.04
2013 Ambasudhan R, Parker J, Ainza C, Dolatabadi N, Ryan S, Le T, Lipton SA, Haas RH. A human reprogrammed-cell model of MELAS Mitochondrion. 13: 943-944. DOI: 10.1016/j.mito.2013.07.112  0.01
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