Colette T. Dooley, Ph.D - Publications

Torrey Pines Institute for Molecular Studies, USA 
GPCRs, Opioids, Combinatorial chemistry, Oxidative Stress

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Li Y, Cazares M, Wu J, Houghten RA, Toll L, Dooley CT. Potent Mu-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological and Structural Evaluation. Journal of Medicinal Chemistry. PMID 26789491 DOI: 10.1021/acs.jmedchem.5b01899  0.32
2015 Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Direct High Throughput In Vivo Screening: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine bis-Piperazines. Acs Combinatorial Science. PMID 26651386 DOI: 10.1021/acscombsci.5b00126  0.32
2015 Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A. Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors. Journal of Medicinal Chemistry. 58: 4905-17. PMID 25996309 DOI: 10.1021/jm501637c  0.32
2015 Hu M, Giulianotti MA, McLaughlin JP, Shao J, Debevec G, Maida LE, Geer P, Cazares M, Misler J, Li L, Dooley C, Ganno ML, Eans SO, Mizrachi E, Santos RG, et al. Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities. European Journal of Medicinal Chemistry. 92: 270-81. PMID 25559207 DOI: 10.1016/j.ejmech.2014.12.049  0.32
2014 Hammami S, Mighri Z, Dooley CT, Nefzi A. Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin. Bioorganic & Medicinal Chemistry Letters. 24: 4482-5. PMID 25168746 DOI: 10.1016/j.bmcl.2014.07.090  0.32
2013 Martinez-Mayorga K, Byler KG, Yongye AB, Giulianotti MA, Dooley CT, Houghten RA. Ligand/kappa-opioid receptor interactions: insights from the X-ray crystal structure. European Journal of Medicinal Chemistry. 66: 114-21. PMID 23792349 DOI: 10.1016/j.ejmech.2013.05.021  0.32
2013 Murru S, Dooley CT, Nefzi A. Parallel synthesis of bis-oxazole peptidomimetics Tetrahedron Letters. 54: 7062-7064. DOI: 10.1016/j.tetlet.2013.10.078  0.32
2012 Li Y, Dooley CT, Misler JA, Debevec G, Giulianotti MA, Cazares ME, Maida L, Houghten RA. Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library. Acs Combinatorial Science. 14: 673-9. PMID 23110623 DOI: 10.1021/co300110t  0.32
2012 Giulianotti MA, Debevec G, Santos RG, Maida LE, Chen W, Ou L, Yu Y, Dooley CT, Houghten RA. A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries. Acs Combinatorial Science. 14: 503-12. PMID 22913403 DOI: 10.1021/co300060s  0.32
2012 Dooley CT, Li L, Misler JA, Thompson JH. Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux. Cell Biology and Toxicology. 28: 89-101. PMID 22228498 DOI: 10.1007/s10565-011-9209-3  0.32
2011 Santos RG, Giulianotti MA, Dooley CT, Pinilla C, Appel JR, Houghten RA. Use and implications of the harmonic mean model on mixtures for basic research and drug discovery. Acs Combinatorial Science. 13: 337-44. PMID 21395284 DOI: 10.1021/co100065a  0.32
2011 Yongye AB, Pinilla C, Medina-Franco JL, Giulianotti MA, Dooley CT, Appel JR, Nefzi A, Scior T, Houghten RA, Martínez-Mayorga K. Integrating computational and mixture-based screening of combinatorial libraries. Journal of Molecular Modeling. 17: 1473-82. PMID 20853183 DOI: 10.1007/s00894-010-0850-1  0.32
2010 Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library. The Aaps Journal. 12: 318-29. PMID 20422341 DOI: 10.1208/s12248-010-9191-3  0.32
2009 Yongye AB, Appel JR, Giulianotti MA, Dooley CT, Medina-Franco JL, Nefzi A, Houghten RA, Martínez-Mayorga K. Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. Bioorganic & Medicinal Chemistry. 17: 5583-97. PMID 19576786 DOI: 10.1016/j.bmc.2009.06.026  0.32
2009 Nagasaki H, Chung S, Dooley CT, Wang Z, Li C, Saito Y, Clark SD, Houghten RA, Civelli O. The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries. European Journal of Pharmacology. 602: 194-202. PMID 19041642 DOI: 10.1016/j.ejphar.2008.10.068  0.32
2008 Martínez-Mayorga K, Medina-Franco JL, Giulianotti MA, Pinilla C, Dooley CT, Appel JR, Houghten RA. Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis. Bioorganic & Medicinal Chemistry. 16: 5932-8. PMID 18468907 DOI: 10.1016/j.bmc.2008.04.061  0.32
2008 Houghten RA, Pinilla C, Giulianotti MA, Appel JR, Dooley CT, Nefzi A, Ostresh JM, Yu Y, Maggiora GM, Medina-Franco JL, Brunner D, Schneider J. Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods. Journal of Combinatorial Chemistry. 10: 3-19. PMID 18067268 DOI: 10.1021/cc7001205  0.32
2007 Pinilla C, Appel J, Dooley C, Blondelle S, Eichler J, Dörner B, Ostresh J, Houghten RA. The versatility of nonsupport-bound combinatorial libraries Combinatorial Peptide and Nonpeptide Libraries: a Handbook. 139-171. DOI: 10.1002/9783527614912.ch05  0.32
2006 Houghten RA, Dooley CT, Appel JR. In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands. The Aaps Journal. 8: E371-82. PMID 16796388 DOI: 10.1208/aapsj080242  0.32
2006 Nefzi A, Ostresh JM, Appel JR, Bidlack J, Dooley CT, Houghten RA. Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries. Bioorganic & Medicinal Chemistry Letters. 16: 4331-8. PMID 16750366 DOI: 10.1016/j.bmcl.2006.05.053  0.32
2006 Houghten RA, Dooley CT, Appel JR. Mixture-Based Combinatorial Libraries Handbook of Biologically Active Peptides. 1487-1494. DOI: 10.1016/B978-012369442-3/50211-7  0.32
2004 Houghten RA, Dooley CT, Appel JR. De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library. Bioorganic & Medicinal Chemistry Letters. 14: 1947-51. PMID 15050634 DOI: 10.1016/j.bmcl.2004.01.090  0.32
2004 Dooley CT, Dore TM, Hanson GT, Jackson WC, Remington SJ, Tsien RY. Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. The Journal of Biological Chemistry. 279: 22284-93. PMID 14985369 DOI: 10.1074/jbc.M312847200  0.32
2000 Dooley CT, Houghten RA. Orphanin FQ/nociceptin receptor binding studies. Peptides. 21: 949-60. PMID 10998528 DOI: 10.1016/S0196-9781(00)00231-X  0.32
1999 Dooley CT, Houghten RA. New opioid peptides, peptidomimetics, and heterocyclic compounds from combinatorial libraries. Biopolymers. 51: 379-90. PMID 10797228 DOI: 10.1002/(SICI)1097-0282(1999)51:6<379::AID-BIP2>3.0.CO;2-E  0.32
1999 Houghten RA, Pinilla C, Appel JR, Blondelle SE, Dooley CT, Eichler J, Nefzi A, Ostresh JM. Mixture-based synthetic combinatorial libraries. Journal of Medicinal Chemistry. 42: 3743-78. PMID 10508425 DOI: 10.1021/jm990174v  0.32
1998 Nefzi A, Dooley C, Ostresh JM, Houghten RA. Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds. Bioorganic & Medicinal Chemistry Letters. 8: 2273-8. PMID 9873527 DOI: 10.1016/S0960-894X(98)00412-0  0.32
1998 Dooley CT, Ny P, Bidlack JM, Houghten RA. Selective ligands for the mu, delta, and kappa opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library. The Journal of Biological Chemistry. 273: 18848-56. PMID 9668060 DOI: 10.1074/jbc.273.30.18848  0.32
1998 Dooley CT, Houghten RA. Synthesis and screening of positional scanning combinatorial libraries. Methods in Molecular Biology (Clifton, N.J.). 87: 13-24. PMID 9523255  0.32
1997 Dooley CT, Spaeth CG, Berzetei-Gurske IP, Craymer K, Adapa ID, Brandt SR, Houghten RA, Toll L. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. The Journal of Pharmacology and Experimental Therapeutics. 283: 735-41. PMID 9353393  0.32
1996 Houghten RA, Blondelle SE, Dooley CT, Dörner B, Eichler J, Ostresh JM. Libraries from libraries: generation and comparison of screening profiles. Molecular Diversity. 2: 41-5. PMID 9238632  0.32
1996 Dooley CT, Houghten RA. Orphanin FQ: receptor binding and analog structure activity relationships in rat brain. Life Sciences. 59: PL23-9. PMID 8684262 DOI: 10.1016/0024-3205(96)00261-5  0.32
1995 Eichler J, Appel JR, Blondelle SE, Dooley CT, Dörner B, Ostresh JM, Pérez-Payá E, Pinilla C, Houghten RA. Peptide, peptidomimetic, and organic synthetic combinatorial libraries. Medicinal Research Reviews. 15: 481-96. PMID 8558988 DOI: 10.1002/med.2610150603  0.32
1995 Pinilla C, Appel J, Blondelle S, Dooley C, Dörner B, Eichler J, Ostresh J, Houghten RA. A review of the utility of soluble peptide combinatorial libraries. Biopolymers. 37: 221-40. PMID 7718744 DOI: 10.1002/bip.360370306  0.32
1995 Dooley CT, Kaplan RA, Chung NN, Schiller PW, Bidlack JM, Houghten RA. Six highly active mu-selective opioid peptides identified from two synthetic combinatorial libraries. Peptide Research. 8: 124-37. PMID 7670227  0.32
1995 Blondelle SE, Pérez-Payá E, Dooley CT, Pinilla C, Houghten RA. Soluble combinatorial libraries of organic, peptidomimetic and peptide diversities Trends in Analytical Chemistry. 14: 83-92. DOI: 10.1016/0165-9936(95)91476-9  0.32
1995 Dooley CT, Houghten RA. A comparison of combinatorial library approaches for the study of opioid compounds Perspectives in Drug Discovery and Design. 2: 287-304. DOI: 10.1007/BF02172068  0.32
1994 Dooley CT, Chung NN, Wilkes BC, Schiller PW, Bidlack JM, Pasternak GW, Houghten RA. An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library. Science (New York, N.Y.). 266: 2019-22. PMID 7801131  0.32
1994 Pinilla C, Appel JR, Blondelle SE, Dooley CT, Eichler J, Ostresh JM, Houghten RA. Versatility of positional scanning synthetic combinatorial libraries for the identification of individual compounds Drug Development Research. 33: 133-145. DOI: 10.1002/ddr.430330210  0.32
1993 Dooley CT, Houghten RA. The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands. Life Sciences. 52: 1509-17. PMID 8387136 DOI: 10.1016/0024-3205(93)90113-H  0.32
1993 Houghten RA, Dooley CT. Synthetic peptide combinatorial libraries may be used to determine peptide ligands for opioid receptors. Nida Research Monograph. 134: 66-74. PMID 8289887  0.32
1993 Dooley CT, Chung NN, Schiller PW, Houghten RA. Acetalins: opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries. Proceedings of the National Academy of Sciences of the United States of America. 90: 10811-5. PMID 8248174  0.32
1993 Houghten RA, Dooley CT. The use of synthetic peptide combinatorial libraries for the determination of peptide ligands in radio-receptor assays: Opioid peptides Bioorganic and Medicinal Chemistry Letters. 3: 405-412. DOI: 10.1016/S0960-894X(01)80222-5  0.32
1992 Houghten RA, Appel JR, Blondelle SE, Cuervo JH, Dooley CT, Pinilla C. The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides. Biotechniques. 13: 412-21. PMID 1382470  0.32
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