cached image

Alan Saghatelian - Publications

Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
natural small molecules

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Muthusamy T, Cordes T, Handzlik MK, You L, Lim EW, Gengatharan J, Pinto AFM, Badur MG, Kolar MJ, Wallace M, Saghatelian A, Metallo CM. Serine restriction alters sphingolipid diversity to constrain tumour growth. Nature. PMID 32788725 DOI: 10.1038/S41586-020-2609-X  0.32
2020 Chen PB, Black AS, Sobel AL, Zhao Y, Mukherjee P, Molparia B, Moore NE, Aleman Muench GR, Wu J, Chen W, Pinto AFM, Maryanoff BE, Saghatelian A, Soroosh P, Torkamani A, et al. Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis. Nature Biotechnology. PMID 32541956 DOI: 10.1038/S41587-020-0549-5  0.64
2020 Erikci Ertunc M, Kok BP, Parsons WH, Wang JG, Tan D, Donaldson CJ, Pinto AFM, Vaughan JM, Ngo N, Lum KM, Henry CL, Coppola AR, Niphakis MJ, Cravatt BF, Saez E, ... Saghatelian A, et al. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. The Journal of Biological Chemistry. PMID 32152231 DOI: 10.1074/Jbc.Ra119.012145  0.88
2019 Wang H, Kolar MJ, Chang T, Rizo J, Konduri S, McNerlin C, Saghatelian A, Siegel D. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. Organic Letters. PMID 31545060 DOI: 10.1021/Acs.Orglett.9B03054  0.32
2019 Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. The Journal of Clinical Investigation. PMID 31449056 DOI: 10.1172/Jci127092  0.32
2019 Syed I, Rubinde Celis MF, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB. PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice. The Journal of Clinical Investigation. 129. PMID 31380811 DOI: 10.1172/Jci122445  0.32
2019 Kolar MJ, Konduri S, Chang T, Wang H, McNerlin C, Ohlsson L, Härröd M, Siegel D, Saghatelian A. Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals. The Journal of Biological Chemistry. PMID 31152059 DOI: 10.1074/Jbc.Ra118.006956  0.32
2019 Tan D, Ertunc ME, Konduri S, Zhang J, Pinto AM, Chu Q, Kahn BB, Siegel D, Saghatelian A. Discovery of FAHFA-containing Triacylglycerols and Their Metabolic Regulation. Journal of the American Chemical Society. PMID 31056915 DOI: 10.1021/Jacs.9B00045  0.32
2018 Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metabolism. PMID 30244974 DOI: 10.1016/J.Cmet.2018.09.007  0.32
2018 Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, ... ... Saghatelian A, et al. Author Correction: Blocking Zika virus vertical transmission. Scientific Reports. 8: 8794. PMID 29867187 DOI: 10.1038/S41598-018-26959-4  0.32
2018 Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A. Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Analytical Chemistry. PMID 29578702 DOI: 10.1021/Acs.Analchem.8B00503  0.32
2018 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, ... ... Saghatelian A, et al. How many human proteoforms are there? Nature Chemical Biology. 14: 206-214. PMID 29443976 DOI: 10.1038/Nchembio.2576  0.88
2018 Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, ... Saghatelian A, et al. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metabolism. 27: 419-427.e4. PMID 29414687 DOI: 10.1016/J.Cmet.2018.01.001  0.32
2018 Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, ... ... Saghatelian A, et al. Blocking Zika virus vertical transmission. Scientific Reports. 8: 1218. PMID 29352135 DOI: 10.1038/S41598-018-19526-4  0.32
2018 Sulli G, Rommel A, Wang X, Kolar MJ, Puca F, Saghatelian A, Plikus MV, Verma IM, Panda S. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. PMID 29320480 DOI: 10.1038/Nature25170  0.32
2018 Sulli G, Rommel A, Wang X, Kolar MJ, Puca F, Saghatelian A, Plikus MV, Verma IM, Panda S. Abstract 5464: Pharmacologic activation of REV-ERBs is lethal in cancer and oncogene-induced senescence Cancer Research. 78: 5464-5464. DOI: 10.1158/1538-7445.Am2018-5464  0.32
2017 Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Reports. 21: 1021-1035. PMID 29069585 DOI: 10.1016/J.Celrep.2017.09.091  0.32
2017 Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. Journal of the American Chemical Society. PMID 28350171 DOI: 10.1021/Jacs.7B01269  0.32
2017 Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, et al. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Scientific Reports. 7: 43515. PMID 28240264 DOI: 10.1038/Srep43515  0.32
2017 Chen P, Zuo H, Xiong H, Kolar MJ, Chu Q, Saghatelian A, Siegwart DJ, Wan Y. Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28049847 DOI: 10.1073/Pnas.1614035114  0.32
2016 Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. Cell Metabolism. PMID 28089566 DOI: 10.1016/J.Cmet.2016.12.009  0.32
2016 Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, ... Saghatelian A, et al. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metabolism. PMID 28041958 DOI: 10.1016/J.Cmet.2016.11.009  0.32
2016 Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, ... ... Saghatelian A, et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nature Medicine. PMID 27643638 DOI: 10.1038/Nm.4181  0.32
2016 Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) protect against colitis by regulating the gut innate and adaptive immune systems. The Journal of Biological Chemistry. PMID 27573241 DOI: 10.1074/Jbc.M115.703835  1
2016 Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. PMID 27509211 DOI: 10.1021/Acs.Biochem.6B00565  1
2016 Pirhaji L, Milani P, Leidl M, Curran T, Avila-Pacheco J, Clish CB, White FM, Saghatelian A, Fraenkel E. Revealing disease-associated pathways by network integration of untargeted metabolomics. Nature Methods. PMID 27479327 DOI: 10.1038/Nmeth.3940  1
2016 Chu Q, Diedrich JK, Vaughan JM, Donaldson CJ, Nunn MF, Lee KF, Saghatelian A. HtrA1 Proteolysis of ApoE in vitro is Allele Selective. Journal of the American Chemical Society. PMID 27379525 DOI: 10.1021/Jacs.6B03463  1
2016 Moraes-Vieira PM, Saghatelian A, Kahn BB. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. Diabetes. PMID 27288004 DOI: 10.2337/Db16-0221  1
2016 Parsons WH, Kolar MJ, Kamat SS, Iii AB, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nature Chemical Biology. PMID 27018888 DOI: 10.1038/Nchembio.2051  1
2016 Ma J, Diedrich JK, Jungreis I, Donaldson C, Vaughan J, Kellis M, Yates JR, Saghatelian A. Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides. Analytical Chemistry. PMID 27010111 DOI: 10.1021/Acs.Analchem.6B00191  1
2016 Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nature Protocols. 11: 747-763. PMID 26985573 DOI: 10.1038/Nprot.2016.040  1
2016 Wei W, Schwaid AG, Wang X, Wang X, Chen S, Chu Q, Saghatelian A, Wan Y. Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects. Cell Metabolism. PMID 26777690 DOI: 10.1016/J.Cmet.2015.12.010  1
2015 Saghatelian A, Nomura DK, Weerapena E. Editorial overview: Omics: The maturation of chemical biology. Current Opinion in Chemical Biology. PMID 26739665 DOI: 10.1016/J.Cbpa.2015.12.005  1
2015 Saghatelian A, Couso JP. Discovery and characterization of smORF-encoded bioactive polypeptides. Nature Chemical Biology. 11: 909-16. PMID 26575237 DOI: 10.1038/Nchembio.1964  1
2015 Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage FH. Primate-Specific ORF0 Contributes to Retrotransposon-Mediated Diversity. Cell. 163: 583-93. PMID 26496605 DOI: 10.1016/J.Cell.2015.09.025  1
2015 Zhang T, Barclay L, Walensky LD, Saghatelian A. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family. Journal of Lipid Research. PMID 26059977 DOI: 10.1194/Jlr.M058750  1
2015 Zamboni N, Saghatelian A, Patti GJ. Defining the Metabolome: Size, Flux, and Regulation. Molecular Cell. 58: 699-706. PMID 26000853 DOI: 10.1016/J.Molcel.2015.04.021  1
2015 Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, ... ... Saghatelian A, et al. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 521: 316-21. PMID 25945737 DOI: 10.1038/Nature14413  1
2015 Chu Q, Ma J, Saghatelian A. Identification and characterization of sORF-encoded polypeptides. Critical Reviews in Biochemistry and Molecular Biology. 50: 134-41. PMID 25857697 DOI: 10.3109/10409238.2015.1016215  1
2015 Kim KJ, Kim YW, Kim YG, Park HM, Jin JM, Hwan Kim Y, Yang YH, Kyu Lee J, Chung J, Lee SG, Saghatelian A. Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG). Biotechnology Progress. 31: 840-8. PMID 25832445 DOI: 10.1002/Btpr.2078  1
2015 Zhang T, Walensky LD, Saghatelian A. A Nonapoptotic Role for BAX and BAK in Eicosanoid Metabolism. Acs Chemical Biology. 10: 1398-403. PMID 25815636 DOI: 10.1021/Acschembio.5B00168  1
2015 Jin Z, Du Y, Schwaid AG, Asterholm IW, Scherer PE, Saghatelian A, Wan Y. Maternal adiponectin controls milk composition to prevent neonatal inflammation. Endocrinology. 156: 1504-13. PMID 25590242 DOI: 10.1210/En.2014-1738  1
2014 Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. Journal of the American Chemical Society. 136: 17710-3. PMID 25496053 DOI: 10.1021/Ja5065735  1
2014 Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 159: 318-32. PMID 25303528 DOI: 10.1016/J.Cell.2014.09.035  1
2014 Johnson LM, Barrick S, Hager MV, McFedries A, Homan EA, Rabaglia ME, Keller MP, Attie AD, Saghatelian A, Bisello A, Gellman SH. A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo. Journal of the American Chemical Society. 136: 12848-51. PMID 25191938 DOI: 10.1021/Ja507168T  0.88
2014 Nazarian A, Lawlor K, Yi SS, Philip J, Ghosh M, Yaneva M, Villanueva J, Saghatelian A, Assel M, Vickers AJ, Eastham JA, Scher HI, Carver BS, Lilja H, Tempst P. Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer. Molecular & Cellular Proteomics : McP. 13: 3082-96. PMID 25056937 DOI: 10.1074/Mcp.M114.038836  1
2014 Oliver PM, Crooks JA, Leidl M, Yoon EJ, Saghatelian A, Weibel DB. Localization of anionic phospholipids in Escherichia coli cells. Journal of Bacteriology. 196: 3386-98. PMID 25002539 DOI: 10.1128/Jb.01877-14  1
2014 Maianti JP, McFedries A, Foda ZH, Kleiner RE, Du XQ, Leissring MA, Tang WJ, Charron MJ, Seeliger MA, Saghatelian A, Liu DR. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. 511: 94-8. PMID 24847884 DOI: 10.1038/Nature13297  1
2014 Slavoff SA, Heo J, Budnik BA, Hanakahi LA, Saghatelian A. A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining. The Journal of Biological Chemistry. 289: 10950-7. PMID 24610814 DOI: 10.1074/Jbc.C113.533968  1
2014 Lone AM, Leidl M, McFedries AK, Horner JW, Creemers J, Saghatelian A. Deletion of PREPl causes growth impairment and hypotonia in mice. Plos One. 9: e89160. PMID 24586561 DOI: 10.1371/Journal.Pone.0089160  1
2014 Ma J, Ward CC, Jungreis I, Slavoff SA, Schwaid AG, Neveu J, Budnik BA, Kellis M, Saghatelian A. Discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue. Journal of Proteome Research. 13: 1757-65. PMID 24490786 DOI: 10.1021/Pr401280W  1
2014 Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science (New York, N.Y.). 343: 1248636. PMID 24407481 DOI: 10.1126/Science.1248636  1
2013 Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 502: 550-4. PMID 24153306 DOI: 10.1038/Nature12710  1
2013 Schwaid AG, Shannon DA, Ma J, Slavoff SA, Levin JZ, Weerapana E, Saghatelian A. Chemoproteomic discovery of cysteine-containing human short open reading frames. Journal of the American Chemical Society. 135: 16750-3. PMID 24152191 DOI: 10.1021/Ja406606J  1
2013 López-Sagaseta J, Dulberger CL, McFedries A, Cushman M, Saghatelian A, Adams EJ. MAIT recognition of a stimulatory bacterial antigen bound to MR1. Journal of Immunology (Baltimore, Md. : 1950). 191: 5268-77. PMID 24108697 DOI: 10.4049/Jimmunol.1301958  1
2013 Kim YG, Lone AM, Saghatelian A. Analysis of the proteolysis of bioactive peptides using a peptidomics approach. Nature Protocols. 8: 1730-42. PMID 23949379 DOI: 10.1038/Nprot.2013.104  1
2013 Mitchell AJ, Lone AM, Tinoco AD, Saghatelian A. Proteolysis controls endogenous substance P levels. Plos One. 8: e68638. PMID 23894327 DOI: 10.1371/Journal.Pone.0068638  1
2013 Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1788-94. PMID 23723371 DOI: 10.1161/Atvbaha.113.301300  1
2013 McFedries A, Schwaid A, Saghatelian A. Methods for the elucidation of protein-small molecule interactions. Chemistry & Biology. 20: 667-73. PMID 23706633 DOI: 10.1016/J.Chembiol.2013.04.008  1
2013 Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, ... Saghatelian A, et al. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 940-63. PMID 23685806 DOI: 10.1039/C3Ib40013A  1
2013 López-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: E1771-8. PMID 23613577 DOI: 10.1073/Pnas.1222678110  1
2013 Zhang T, Saghatelian A. Emerging roles of lipids in BCL-2 family-regulated apoptosis. Biochimica Et Biophysica Acta. 1831: 1542-54. PMID 23524027 DOI: 10.1016/J.Bbalip.2013.03.001  1
2013 Lone AM, Kim YG, Saghatelian A. Peptidomics methods for the identification of peptidase-substrate interactions. Current Opinion in Chemical Biology. 17: 83-9. PMID 23332665 DOI: 10.1016/J.Cbpa.2012.10.038  1
2013 Cezairliyan B, Vinayavekhin N, Grenfell-Lee D, Yuen GJ, Saghatelian A, Ausubel FM. Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. Plos Pathogens. 9: e1003101. PMID 23300454 DOI: 10.1371/Journal.Ppat.1003101  1
2013 Slavoff SA, Mitchell AJ, Schwaid AG, Cabili MN, Ma J, Levin JZ, Karger AD, Budnik BA, Rinn JL, Saghatelian A. Peptidomic discovery of short open reading frame-encoded peptides in human cells. Nature Chemical Biology. 9: 59-64. PMID 23160002 DOI: 10.1038/Nchembio.1120  1
2012 Slavoff SA, Saghatelian A. Discovering ligand-receptor interactions. Nature Biotechnology. 30: 959-61. PMID 23051814 DOI: 10.1038/Nbt.2373  1
2012 Du Y, Yang M, Wei W, Huynh HD, Herz J, Saghatelian A, Wan Y. Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. Nature Communications. 3: 1008. PMID 22910354 DOI: 10.1038/Ncomms2011  1
2012 Du Y, Yang M, Lee S, Behrendt CL, Hooper LV, Saghatelian A, Wan Y. Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity. Genes & Development. 26: 1306-11. PMID 22713870 DOI: 10.1101/Gad.191031.112  1
2012 Kim YG, Lone AM, Nolte WM, Saghatelian A. Peptidomics approach to elucidate the proteolytic regulation of bioactive peptides. Proceedings of the National Academy of Sciences of the United States of America. 109: 8523-7. PMID 22586115 DOI: 10.1073/Pnas.1203195109  1
2012 Tinoco AD, Thomas HR, Incarvito CD, Saghatelian A, Valentine AM. Cytotoxicity of a Ti(IV) compound is independent of serum proteins. Proceedings of the National Academy of Sciences of the United States of America. 109: 5016-21. PMID 22411801 DOI: 10.1073/Pnas.1119303109  1
2012 Guzman-Rojas L, Rangel R, Salameh A, Edwards JK, Dondossola E, Kim YG, Saghatelian A, Giordano RJ, Kolonin MG, Staquicini FI, Koivunen E, Sidman RL, Arap W, Pasqualini R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. Proceedings of the National Academy of Sciences of the United States of America. 109: 1637-42. PMID 22307623 DOI: 10.1073/Pnas.1120790109  1
2012 Kim YG, Saghatelian A. Functional analysis of protein targets by metabolomic approaches. Topics in Current Chemistry. 324: 137-62. PMID 22083210 DOI: 10.1007/128_2011_284  1
2011 Vinayavekhin N, Saghatelian A. Discovery of a protein-metabolite interaction between unsaturated fatty acids and the nuclear receptor Nur77 using a metabolomics approach. Journal of the American Chemical Society. 133: 17168-71. PMID 21973308 DOI: 10.1021/Ja208199H  1
2011 Tinoco AD, Saghatelian A. Investigating endogenous peptides and peptidases using peptidomics. Biochemistry. 50: 7447-61. PMID 21786763 DOI: 10.1021/Bi200417K  1
2011 Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J. VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses. Plos One. 6: e21209. PMID 21750705 DOI: 10.1371/Journal.Pone.0021209  1
2011 Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF, Saghatelian A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Journal of the American Chemical Society. 133: 11665-74. PMID 21692504 DOI: 10.1021/Ja2036095  1
2011 Homan EA, Kim YG, Cardia JP, Saghatelian A. Monoalkylglycerol ether lipids promote adipogenesis. Journal of the American Chemical Society. 133: 5178-81. PMID 21428285 DOI: 10.1021/Ja111173C  1
2011 Tinoco AD, Kim YG, Tagore DM, Wiwczar J, Lane WS, Danial NN, Saghatelian A. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. Biochemistry. 50: 2213-22. PMID 21299233 DOI: 10.1021/Bi2000033  1
2011 Kim YG, Lou AC, Saghatelian A. A metabolomics strategy for detecting protein-metabolite interactions to identify natural nuclear receptor ligands. Molecular Biosystems. 7: 1046-9. PMID 21283866 DOI: 10.1039/C0Mb00324G  1
2010 Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ. The 2.5 Ã… structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity. 33: 853-62. PMID 21167756 DOI: 10.1016/J.Immuni.2010.11.026  1
2010 Lone AM, Nolte WM, Tinoco AD, Saghatelian A. Peptidomics of the prolyl peptidases. The Aaps Journal. 12: 483-91. PMID 20552307 DOI: 10.1208/S12248-010-9208-Y  1
2010 Vinayavekhin N, Saghatelian A. Untargeted metabolomics. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 30.1.1-24. PMID 20373502 DOI: 10.1002/0471142727.mb3001s90  1
2010 Tinoco AD, Tagore DM, Saghatelian A. Expanding the dipeptidyl peptidase 4-regulated peptidome via an optimized peptidomics platform. Journal of the American Chemical Society. 132: 3819-30. PMID 20178363 DOI: 10.1021/Ja909524E  1
2010 Vinayavekhin N, Homan EA, Saghatelian A. Exploring disease through metabolomics. Acs Chemical Biology. 5: 91-103. PMID 20020774 DOI: 10.1021/Cb900271R  1
2009 Nolte WM, Tagore DM, Lane WS, Saghatelian A. Peptidomics of prolyl endopeptidase in the central nervous system. Biochemistry. 48: 11971-81. PMID 19911840 DOI: 10.1021/Bi901637C  1
2009 MacBeath G, Saghatelian A. The promise and challenge of '-omic' approaches. Current Opinion in Chemical Biology. 13: 501-2. PMID 19853495 DOI: 10.1016/J.Cbpa.2009.10.008  1
2009 Vinayavekhin N, Saghatelian A. Regulation of alkyl-dihydrothiazole-carboxylates (ATCs) by iron and the pyochelin gene cluster in Pseudomonas aeruginosa. Acs Chemical Biology. 4: 617-23. PMID 19621937 DOI: 10.1021/Cb900075N  1
2009 Rodgers MA, Saghatelian A, Yang PL. Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. Journal of the American Chemical Society. 131: 5030-1. PMID 19301856 DOI: 10.1021/Ja809949R  1
2009 Tagore DM, Nolte WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R, Arap W, Lane WS, Saghatelian A. Peptidase substrates via global peptide profiling. Nature Chemical Biology. 5: 23-5. PMID 19011639 DOI: 10.1038/Nchembio.126  1
2008 Tagore R, Thomas HR, Homan EA, Munawar A, Saghatelian A. A global metabolite profiling approach to identify protein-metabolite interactions. Journal of the American Chemical Society. 130: 14111-3. PMID 18831549 DOI: 10.1021/Ja806463C  1
2008 Voelcker NH, Guckian KM, Saghatelian A, Ghadiri MR. Sequence-addressable DNA logic. Small (Weinheim An Der Bergstrasse, Germany). 4: 427-31. PMID 18350554 DOI: 10.1002/Smll.200700113  1
2007 Chamero P, Marton TF, Logan DW, Flanagan K, Cruz JR, Saghatelian A, Cravatt BF, Stowers L. Identification of protein pheromones that promote aggressive behaviour. Nature. 450: 899-902. PMID 18064011 DOI: 10.1038/Nature05997  1
2007 Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. Genes & Development. 21: 1895-908. PMID 17652179 DOI: 10.1101/Gad.1567207  1
2007 Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter BR, Gygi SP. Assessing enzyme activities using stable isotope labeling and mass spectrometry. Molecular & Cellular Proteomics : McP. 6: 1771-7. PMID 17627935 DOI: 10.1074/Mcp.M700057-Mcp200  1
2007 Ostash B, Saghatelian A, Walker S. A streamlined metabolic pathway for the biosynthesis of moenomycin A. Chemistry & Biology. 14: 257-67. PMID 17379141 DOI: 10.1016/J.Chembiol.2007.01.008  1
2006 Chiang KP, Niessen S, Saghatelian A, Cravatt BF. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chemistry & Biology. 13: 1041-50. PMID 17052608 DOI: 10.1016/J.Chembiol.2006.08.008  1
2006 Saghatelian A, McKinney MK, Bandell M, Patapoutian A, Cravatt BF. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry. 45: 9007-15. PMID 16866345 DOI: 10.1021/Bi0608008  1
2006 Leung D, Saghatelian A, Simon GM, Cravatt BF. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry. 45: 4720-6. PMID 16605240 DOI: 10.1021/Bi060163L  1
2005 Saghatelian A, Cravatt BF. Assignment of protein function in the postgenomic era. Nature Chemical Biology. 1: 130-42. PMID 16408016 DOI: 10.1038/Nchembio0805-130  1
2005 Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nature Biotechnology. 23: 1303-7. PMID 16200062 DOI: 10.1038/Nbt1149  1
2005 Saghatelian A, Cravatt BF. Discovery metabolite profiling--forging functional connections between the proteome and metabolome. Life Sciences. 77: 1759-66. PMID 15964030 DOI: 10.1016/J.Lfs.2005.05.019  1
2005 Go EP, Apon JV, Luo G, Saghatelian A, Daniels RH, Sahi V, Dubrow R, Cravatt BF, Vertes A, Siuzdak G. Desorption/ionization on silicon nanowires. Analytical Chemistry. 77: 1641-6. PMID 15762567 DOI: 10.1021/Ac048460O  1
2005 Saghatelian A, Cravatt BF. Global strategies to integrate the proteome and metabolome. Current Opinion in Chemical Biology. 9: 62-8. PMID 15701455 DOI: 10.1016/J.Cbpa.2004.12.004  1
2004 Saghatelian A, Trauger SA, Want EJ, Hawkins EG, Siuzdak G, Cravatt BF. Assignment of endogenous substrates to enzymes by global metabolite profiling. Biochemistry. 43: 14332-9. PMID 15533037 DOI: 10.1021/Bi0480335  1
2004 Cravatt BF, Saghatelian A, Hawkins EG, Clement AB, Bracey MH, Lichtman AH. Functional disassociation of the central and peripheral fatty acid amide signaling systems. Proceedings of the National Academy of Sciences of the United States of America. 101: 10821-6. PMID 15247426 DOI: 10.1073/Pnas.0401292101  1
2004 Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BF. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. The Journal of Pharmacology and Experimental Therapeutics. 311: 441-8. PMID 15229230 DOI: 10.1124/Jpet.104.069401  1
2004 Saghatelian A, Jessani N, Joseph A, Humphrey M, Cravatt BF. Activity-based probes for the proteomic profiling of metalloproteases. Proceedings of the National Academy of Sciences of the United States of America. 101: 10000-5. PMID 15220480 DOI: 10.1073/Pnas.0402784101  1
2004 Sánchez-Quesada J, Saghatelian A, Cheley S, Bayley H, Ghadiri MR. Single DNA rotaxanes of a transmembrane pore protein. Angewandte Chemie (International Ed. in English). 43: 3063-7. PMID 15188482 DOI: 10.1002/Anie.200453907  1
2003 Saghatelian A, Völcker NH, Guckian KM, Lin VS, Ghadiri MR. DNA-based photonic logic gates: AND, NAND, and INHIBIT. Journal of the American Chemical Society. 125: 346-7. PMID 12517142 DOI: 10.1021/Ja029009M  1
2003 Saghatelian A, Guckian KM, Thayer DA, Ghadiri MR. DNA detection and signal amplification via an engineered allosteric enzyme. Journal of the American Chemical Society. 125: 344-5. PMID 12517141 DOI: 10.1021/Ja027885U  1
2001 Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A, Mammen J. Total synthesis of the calphostins: application of fischer carbene complexes and thermodynamic control of atropisomers. The Journal of Organic Chemistry. 66: 1297-309. PMID 11312960 DOI: 10.1021/Jo0014663  1
2001 Saghatelian A, Yokobayashi Y, Soltani K, Ghadiri MR. A chiroselective peptide replicator. Nature. 409: 797-801. PMID 11236988 DOI: 10.1038/35057238  0.6
2001 Saghatelian A, Buriak J, Lin VSY, Ghadiri MR. Transition metal mediated surface modification of porous silicon Tetrahedron. 57: 5131-5136. DOI: 10.1016/S0040-4020(01)00366-0  1
2000 Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A. Carbene Complexes in the Synthesis of Complex Natural Products: Total Synthesis of the Calphostins. Journal of the American Chemical Society. 122: 3224-3225. PMID 23335811 DOI: 10.1021/Ja994313+  0.72
2000 Merlic CA, Aldrich CC, Albaneze-Walker J, Saghatelian A. Carbene complexes in the synthesis of complex natural products: Total synthesis of the calphostins [5] Journal of the American Chemical Society. 122: 3224-3225. DOI: 10.1021/ja994313+  1
Show low-probability matches.