Catherine L. Drennan - Publications

Affiliations: 
Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
X–ray crystallography to study the structure and mechanism of metalloproteins
Website:
http://web.mit.edu/chemistry/www/faculty/drennan.html

146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wittenborn EC, Cohen SE, Merrouch M, Léger C, Fourmond V, Dementin S, Drennan CL. Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase. The Journal of Biological Chemistry. PMID 31296570 DOI: 10.1074/jbc.RA119.009610  0.92
2019 Chen PY, DeColli AA, Freel Meyers CL, Drennan CL. X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1‑deoxy‑d‑xylulose 5-phosphate synthase reaction coordinate. The Journal of Biological Chemistry. PMID 31239351 DOI: 10.1074/jbc.RA119.009321  0.92
2019 Bian K, Lenz SAP, Tang Q, Chen F, Qi R, Jost M, Drennan CL, Essigmann JM, Wetmore SD, Li D. DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro. Nucleic Acids Research. PMID 31114894 DOI: 10.1093/nar/gkz395  1
2019 Chen PY, Li B, Drennan CL, Elliott SJ. A reverse TCA cycle 2-oxoacid:ferredoxin oxidoreductase that makes C-C bonds from CO. Joule. 3: 595-611. PMID 31080943 DOI: 10.1016/j.joule.2018.12.006  0.92
2019 Rizzolo K, Cohen SE, Weitz AC, López Muñoz MM, Hendrich MP, Drennan CL, Elliott SJ. A widely distributed diheme enzyme from Burkholderia that displays an atypically stable bis-Fe(IV) state. Nature Communications. 10: 1101. PMID 30846684 DOI: 10.1038/s41467-019-09020-4  0.56
2018 Orman M, Bodea S, Funk MA, Campo AM, Bollenbach M, Drennan CL, Balskus EP. Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria. Journal of the American Chemical Society. PMID 30557011 DOI: 10.1021/jacs.8b04883  0.64
2018 Grell TAJ, Bell BN, Nguyen C, Dowling DP, Bruender NA, Bandarian V, Drennan CL. Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. Protein Science : a Publication of the Protein Society. PMID 30341796 DOI: 10.1002/pro.3529  1
2018 Wittenborn EC, Merrouch M, Ueda C, Fradale L, Léger C, Fourmond V, Pandelia ME, Dementin S, Drennan CL. Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. Elife. 7. PMID 30277213 DOI: 10.7554/eLife.39451  0.92
2018 Grell TAJ, Kincannon WM, Bruender NA, Blaesi EJ, Krebs C, Bandarian V, Drennan CL. Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase. The Journal of Biological Chemistry. PMID 30217813 DOI: 10.1074/jbc.RA118.005369  1
2018 Ryan KS, Drennan CL. Metalloenzymes in natural product biosynthetic pathways. Natural Product Reports. PMID 30009301 DOI: 10.1039/c8np90023j  0.96
2018 Bridwell-Rabb J, Grell TAJ, Drennan CL. A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited. Annual Review of Biochemistry. 87: 555-584. PMID 29925255 DOI: 10.1146/annurev-biochem-062917-012500  1
2018 Grell TAJ, Young AP, Drennan CL, Bandarian V. Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1. Journal of the American Chemical Society. PMID 29792696 DOI: 10.1021/jacs.8b01493  1
2018 Chen PY, Funk MA, Brignole EJ, Drennan CL. Disruption of an oligomeric interface prevents allosteric inhibition of class Ia ribonucleotide reductase. The Journal of Biological Chemistry. PMID 29700111 DOI: 10.1074/jbc.RA118.002569  1
2018 Chen PY, Aman H, Can M, Ragsdale SW, Drennan CL. Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreductase from. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581263 DOI: 10.1073/pnas.1722329115  0.92
2018 Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife. 7. PMID 29460780 DOI: 10.7554/eLife.31502  1
2017 Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL. Structural basis for methylphosphonate biosynthesis. Science (New York, N.Y.). 358: 1336-1339. PMID 29217579 DOI: 10.1126/science.aao3435  0.44
2017 Backman LRF, Funk MA, Dawson CD, Drennan CL. New tricks for the glycyl radical enzyme family. Critical Reviews in Biochemistry and Molecular Biology. 1-22. PMID 28901199 DOI: 10.1080/10409238.2017.1373741  0.64
2017 Shisler KA, Hutcheson RU, Horitani M, Duschene KS, Crain AV, Byer AS, Shepard EM, Rasmussen A, Yang J, Broderick WE, Vey JL, Drennan CL, Hoffman BM, Broderick JB. Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme. Journal of the American Chemical Society. PMID 28768413 DOI: 10.1021/jacs.7b04883  0.36
2017 Padmanabhan S, Jost M, Drennan CL, Elías-Arnanz M. A New Facet of Vitamin B12: Gene Regulation by Cobalamin-Based Photoreceptors. Annual Review of Biochemistry. 86: 485-514. PMID 28654327 DOI: 10.1146/annurev-biochem-061516-044500  0.44
2017 Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP. Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 28634302 DOI: 10.1073/pnas.1702849114  0.64
2017 Lin Q, Parker MJ, Taguchi AT, Ravichandran K, Kim A, Kang G, Shao J, Drennan CL, Stubbe J. Glutamate 52-β at the α/β Subunit Interface of E. coli Class Ia Ribonucleotide Reductase is essential for Conformational Gating of Radical Transfer. The Journal of Biological Chemistry. PMID 28377505 DOI: 10.1074/jbc.M117.783092  0.64
2017 Bridwell-Rabb J, Zhong A, Sun HG, Drennan CL, Liu HW. A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis. Nature. 544: 322-326. PMID 28346939 DOI: 10.1038/nature21689  1
2017 Bridwell-Rabb J, Drennan CL. Vitamin B12 in the spotlight again. Current Opinion in Chemical Biology. 37: 63-70. PMID 28167430 DOI: 10.1016/j.cbpa.2017.01.013  1
2017 Bruender NA, Grell TA, Dowling DP, McCarty RM, Drennan CL, Bandarian V. 7-Carboxy-7-deazaguanine synthase - A radical S-adenosyl-L-methionine enzyme with polar tendencies. Journal of the American Chemical Society. PMID 28045519 DOI: 10.1021/jacs.6b11381  0.6
2016 Bridwell-Rabb J, Kang G, Zhong A, Liu HW, Drennan CL. An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 113: 13750-13755. PMID 27849620 DOI: 10.1073/pnas.1613610113  1
2016 Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL. Structural elements of an NRPS cyclization domain and its intermodule docking domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791103 DOI: 10.1073/pnas.1608615113  1
2016 Wittenborn EC, Jost M, Wei Y, Stubbe J, Drennan CL. Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator. The Journal of Biological Chemistry. PMID 27742839 DOI: 10.1074/jbc.M116.756833  1
2016 Bodea S, Funk MA, Balskus EP, Drennan CL. Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase. Cell Chemical Biology. PMID 27642068 DOI: 10.1016/j.chembiol.2016.07.020  0.64
2016 Dowling DP, Miles ZD, Köhrer C, Maiocco SJ, Elliott SJ, Bandarian V, Drennan CL. Molecular basis of cobalamin-dependent RNA modification. Nucleic Acids Research. PMID 27638883 DOI: 10.1093/nar/gkw806  1
2016 Gibson MI, Chen PY, Drennan CL. A structural phylogeny for understanding 2-oxoacid oxidoreductase function. Current Opinion in Structural Biology. 41: 54-61. PMID 27315560 DOI: 10.1016/j.sbi.2016.05.011  0.92
2016 Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J. Biophysical characterization of fluorotyrosine probes site-specifically incorporated into enzymes: E. coli ribonucleotide reductase as an example. Journal of the American Chemical Society. PMID 27276098 DOI: 10.1021/jacs.6b03605  1
2016 Bridwell-Rabb J, Drennan CL. BIOCHEMISTRY. A radically unexpected mechanism. Science (New York, N.Y.). 351: 1266-7. PMID 26989237 DOI: 10.1126/science.aaf4942  1
2016 Bowman SE, Bridwell-Rabb J, Drennan CL. Metalloprotein Crystallography: More than a Structure. Accounts of Chemical Research. 49: 695-702. PMID 26975689 DOI: 10.1021/acs.accounts.5b00538  1
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Drennan CL, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/ncomms10882  1
2016 Chen F, Tang Q, Bian K, Humulock ZT, Yang X, Jost M, Drennan CL, Essigmann JM, Li D. The Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA. Chemical Research in Toxicology. PMID 26919079 DOI: 10.1021/acs.chemrestox.5b00522  1
2016 Chen PY, Wittenborn EC, Drennan CL. Waltzing around cofactors. Elife. 5. PMID 26843316 DOI: 10.7554/eLife.13977  0.92
2016 Zimanyi CM, Chen PY, Kang G, Funk MA, Drennan CL. Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife. 5. PMID 26754917 DOI: 10.7554/eLife.07141  1
2016 Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL. Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry. PMID 26727048 DOI: 10.1021/acs.biochem.5b01207  1
2015 Gibson MI, Chen PY, Johnson AC, Pierce E, Can M, Ragsdale SW, Drennan CL. One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. PMID 26712008 DOI: 10.1073/pnas.1518537113  1
2015 Bandarian V, Drennan CL. Radical-mediated ring contraction in the biosynthesis of 7-deazapurines. Current Opinion in Structural Biology. 35: 116-124. PMID 26643180 DOI: 10.1016/j.sbi.2015.11.005  1
2015 Jost M, Fernández-Zapata J, Polanco MC, Ortiz-Guerrero JM, Chen PY, Kang G, Padmanabhan S, Elías-Arnanz M, Drennan CL. Structural basis for gene regulation by a B12-dependent photoreceptor. Nature. PMID 26416754 DOI: 10.1038/nature14950  1
2015 Jost M, Born DA, Cracan V, Banerjee R, Drennan CL. Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases. The Journal of Biological Chemistry. 290: 26882-98. PMID 26318610 DOI: 10.1074/jbc.M115.676890  1
2015 Funk MA, Marsh EN, Drennan CL. Substrate-bound Structures of Benzylsuccinate Synthase Reveal How Toluene Is Activated in Anaerobic Hydrocarbon Degradation. The Journal of Biological Chemistry. 290: 22398-22408. PMID 26224635 DOI: 10.1074/jbc.M115.670737  1
2015 Gibson MI, Brignole EJ, Pierce E, Can M, Ragsdale SW, Drennan CL. The Structure of an Oxalate Oxidoreductase Provides Insight into Microbial 2-Oxoacid Metabolism. Biochemistry. 54: 4112-20. PMID 26061898 DOI: 10.1021/acs.biochem.5b00521  1
2015 Jost M, Simpson JH, Drennan CL. The Transcription Factor CarH Safeguards Use of Adenosylcobalamin as a Light Sensor by Altering the Photolysis Products. Biochemistry. 54: 3231-4. PMID 25966286 DOI: 10.1021/acs.biochem.5b00416  1
2015 Mattaini KR, Brignole EJ, Kini M, Davidson SM, Fiske BP, Drennan CL, Vander Heiden MG. An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation. Cancer & Metabolism. 3: 5. PMID 25926973 DOI: 10.1186/s40170-015-0131-7  1
2015 Bewley KD, Dey M, Bjork RE, Mitra S, Chobot SE, Drennan CL, Elliott SJ. Rheostat re-wired: alternative hypotheses for the control of thioredoxin reduction potentials. Plos One. 10: e0122466. PMID 25874934 DOI: 10.1371/journal.pone.0122466  1
2015 Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, et al. Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in vivo. Nucleic Acids Research. 43: 5489-500. PMID 25837992 DOI: 10.1093/nar/gkv243  1
2015 Jost M, Cracan V, Hubbard PA, Banerjee R, Drennan CL. Visualization of a radical B12 enzyme with its G-protein chaperone. Proceedings of the National Academy of Sciences of the United States of America. 112: 2419-24. PMID 25675500 DOI: 10.1073/pnas.1419582112  1
2015 Gagnon DM, Brophy MB, Bowman SE, Stich TA, Drennan CL, Britt RD, Nolan EM. Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. Journal of the American Chemical Society. 137: 3004-16. PMID 25597447 DOI: 10.1021/ja512204s  1
2015 Grell TA, Goldman PJ, Drennan CL. SPASM and twitch domains in S-adenosylmethionine (SAM) radical enzymes. The Journal of Biological Chemistry. 290: 3964-71. PMID 25477505 DOI: 10.1074/jbc.R114.581249  1
2014 Liu DS, Nivón LG, Richter F, Goldman PJ, Deerinck TJ, Yao JZ, Richardson D, Phipps WS, Ye AZ, Ellisman MH, Drennan CL, Baker D, Ting AY. Computational design of a red fluorophore ligase for site-specific protein labeling in living cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E4551-9. PMID 25313043 DOI: 10.1073/pnas.1404736111  1
2014 Setser JW, Heemstra JR, Walsh CT, Drennan CL. Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase. Biochemistry. 53: 6063-77. PMID 25184411 DOI: 10.1021/bi500655q  1
2014 Wei Y, Funk MA, Rosado LA, Baek J, Drennan CL, Stubbe J. The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant. Proceedings of the National Academy of Sciences of the United States of America. 111: E3756-65. PMID 25157154 DOI: 10.1073/pnas.1414396111  1
2014 Funk MA, Judd ET, Marsh EN, Elliott SJ, Drennan CL. Structures of benzylsuccinate synthase elucidate roles of accessory subunits in glycyl radical enzyme activation and activity. Proceedings of the National Academy of Sciences of the United States of America. 111: 10161-6. PMID 24982148 DOI: 10.1073/pnas.1405983111  1
2014 Dowling DP, Bruender NA, Young AP, McCarty RM, Bandarian V, Drennan CL. Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nature Chemical Biology. 10: 106-12. PMID 24362703 DOI: 10.1038/nchembio.1426  1
2013 Sydor AM, Jost M, Ryan KS, Turo KE, Douglas CD, Drennan CL, Zamble DB. Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases. Biochemistry. 52: 1788-1801. PMID 24449932 DOI: 10.1021/bi301600z  1
2013 Goldman PJ, Grove TL, Booker SJ, Drennan CL. X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry. Proceedings of the National Academy of Sciences of the United States of America. 110: 15949-54. PMID 24048029 DOI: 10.1073/pnas.1312228110  1
2013 Li D, Fedeles BI, Shrivastav N, Delaney JC, Yang X, Wong C, Drennan CL, Essigmann JM. Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB. Chemical Research in Toxicology. 26: 1182-7. PMID 23773213 DOI: 10.1021/tx400096m  1
2013 Goldman PJ, Grove TL, Sites LA, McLaughlin MI, Booker SJ, Drennan CL. X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proceedings of the National Academy of Sciences of the United States of America. 110: 8519-24. PMID 23650368 DOI: 10.1073/pnas.1302417110  1
2013 Chang WC, Dey M, Liu P, Mansoorabadi SO, Moon SJ, Zhao ZK, Drennan CL, Liu HW. Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction. Nature. 496: 114-8. PMID 23552950 DOI: 10.1038/nature11998  1
2013 Kulik HJ, Drennan CL. Substrate placement influences reactivity in non-heme Fe(II) halogenases and hydroxylases. The Journal of Biological Chemistry. 288: 11233-41. PMID 23449977 DOI: 10.1074/jbc.M112.415570  1
2013 Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J. Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 110: 3835-40. PMID 23431160 DOI: 10.1073/pnas.1220691110  1
2012 Hamill MJ, Jost M, Wong C, Bene NC, Drennan CL, Elliott SJ. Electrochemical characterization of Escherichia coli adaptive response protein AidB. International Journal of Molecular Sciences. 13: 16899-915. PMID 23443126 DOI: 10.3390/ijms131216899  1
2012 Bewley KD, Firer-Sherwood MA, Mock JY, Ando N, Drennan CL, Elliott SJ. Mind the gap: diversity and reactivity relationships among multihaem cytochromes of the MtrA/DmsE family. Biochemical Society Transactions. 40: 1268-73. PMID 23176466 DOI: 10.1042/BST20120106  1
2012 Ando N, Kung Y, Can M, Bender G, Ragsdale SW, Drennan CL. Transient B12-dependent methyltransferase complexes revealed by small-angle X-ray scattering. Journal of the American Chemical Society. 134: 17945-54. PMID 23051056 DOI: 10.1021/ja3055782  1
2012 Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL. An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chemistry & Biology. 19: 855-65. PMID 22840773 DOI: 10.1016/j.chembiol.2012.05.016  1
2012 Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J. Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chemistry & Biology. 19: 799-805. PMID 22840768 DOI: 10.1016/j.chembiol.2012.05.015  1
2012 Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL. Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure (London, England : 1993). 20: 1374-83. PMID 22727814 DOI: 10.1016/j.str.2012.05.009  1
2012 Brignole EJ, Ando N, Zimanyi CM, Drennan CL. The prototypic class Ia ribonucleotide reductase from Escherichia coli: still surprising after all these years. Biochemical Society Transactions. 40: 523-30. PMID 22616862 DOI: 10.1042/BST20120081  1
2012 Ragsdale SW, Yi L, Bender G, Gupta N, Kung Y, Yan L, Stich TA, Doukov T, Leichert L, Jenkins PM, Bianchetti CM, George SJ, Cramer SP, Britt RD, Jakob U, ... ... Drennan CL, et al. Redox, haem and CO in enzymatic catalysis and regulation. Biochemical Society Transactions. 40: 501-7. PMID 22616859 DOI: 10.1042/BST20120083  1
2012 Dowling DP, Vey JL, Croft AK, Drennan CL. Structural diversity in the AdoMet radical enzyme superfamily. Biochimica Et Biophysica Acta. 1824: 1178-95. PMID 22579873 DOI: 10.1016/j.bbapap.2012.04.006  1
2012 Dowling DP, Croft AK, Drennan CL. Radical use of Rossmann and TIM barrel architectures for controlling coenzyme B12 chemistry. Annual Review of Biophysics. 41: 403-27. PMID 22577824 DOI: 10.1146/annurev-biophys-050511-102225  1
2012 Li D, Delaney JC, Page CM, Yang X, Chen AS, Wong C, Drennan CL, Essigmann JM. Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB. Journal of the American Chemical Society. 134: 8896-901. PMID 22512456 DOI: 10.1021/ja3010094  1
2012 Kung Y, Ando N, Doukov TI, Blasiak LC, Bender G, Seravalli J, Ragsdale SW, Drennan CL. Visualizing molecular juggling within a B12-dependent methyltransferase complex. Nature. 484: 265-9. PMID 22419154 DOI: 10.1038/nature10916  1
2012 Setser JW, Lingaraju GM, Davis CA, Samson LD, Drennan CL. Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase. Biochemistry. 51: 382-90. PMID 22148158 DOI: 10.1021/bi201484k  1
2011 Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL. Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proceedings of the National Academy of Sciences of the United States of America. 108: 21046-51. PMID 22160671 DOI: 10.1073/pnas.1112715108  1
2011 Anderson WA, Amasino RM, Ares M, Banerjee U, Bartel B, Corces VG, Drennan CL, Elgin SC, Epstein IR, Fanning E, Guillette LJ, Handelsman J, Hatfull GF, Hoy RR, Kelley D, et al. Competencies: a cure for pre-med curriculum. Science (New York, N.Y.). 334: 760-1. PMID 22076362 DOI: 10.1126/science.334.6057.760-b  1
2011 Hamill MJ, Jost M, Wong C, Elliott SJ, Drennan CL. Flavin-induced oligomerization in Escherichia coli adaptive response protein AidB. Biochemistry. 50: 10159-69. PMID 22004173 DOI: 10.1021/bi201340t  1
2011 Firer-Sherwood MA, Ando N, Drennan CL, Elliott SJ. Solution-based structural analysis of the decaheme cytochrome, MtrA, by small-angle X-ray scattering and analytical ultracentrifugation. The Journal of Physical Chemistry. B. 115: 11208-14. PMID 21838277 DOI: 10.1021/jp203603r  1
2011 Yun D, Dey M, Higgins LJ, Yan F, Liu HW, Drennan CL. Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis. Journal of the American Chemical Society. 133: 11262-9. PMID 21682308 DOI: 10.1021/ja2025728  1
2011 Vey JL, Drennan CL. Structural insights into radical generation by the radical SAM superfamily. Chemical Reviews. 111: 2487-506. PMID 21370834 DOI: 10.1021/cr9002616  1
2011 Lingaraju GM, Davis CA, Setser JW, Samson LD, Drennan CL. Structural basis for the inhibition of human alkyladenine DNA glycosylase (AAG) by 3,N4-ethenocytosine-containing DNA. The Journal of Biological Chemistry. 286: 13205-13. PMID 21349833 DOI: 10.1074/jbc.M110.192435  1
2011 Anderson WA, Banerjee U, Drennan CL, Elgin SC, Epstein IR, Handelsman J, Hatfull GF, Losick R, O'Dowd DK, Olivera BM, Strobel SA, Walker GC, Warner IM. Science education. Changing the culture of science education at research universities. Science (New York, N.Y.). 331: 152-3. PMID 21233371 DOI: 10.1126/science.1198280  1
2011 Kung Y, Drennan CL. A role for nickel-iron cofactors in biological carbon monoxide and carbon dioxide utilization. Current Opinion in Chemical Biology. 15: 276-83. PMID 21130022 DOI: 10.1016/j.cbpa.2010.11.005  1
2010 Taylor EV, Fortune JA, Drennan CL. A research-inspired laboratory sequence investigating acquired drug resistance. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 38: 247-52. PMID 21567836 DOI: 10.1002/bmb.20384  1
2010 Li D, Delaney JC, Page CM, Chen AS, Wong C, Drennan CL, Essigmann JM. Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry. Journal of Nucleic Acids. 2010: 369434. PMID 21048928 DOI: 10.4061/2010/369434  1
2010 Drennan CL. In the nickel of time. Nature Chemistry. 2: 900. PMID 20861908 DOI: 10.1038/nchem.854  1
2010 Phillips CM, Stultz CM, Drennan CL. Searching for the Nik operon: how a ligand-responsive transcription factor hunts for its DNA binding site. Biochemistry. 49: 7757-63. PMID 20712334 DOI: 10.1021/bi100947k  1
2010 Phillips CM, Schreiter ER, Stultz CM, Drennan CL. Structural basis of low-affinity nickel binding to the nickel-responsive transcription factor NikR from Escherichia coli. Biochemistry. 49: 7830-8. PMID 20704276 DOI: 10.1021/bi100923j  1
2009 Taylor EM, Mitchell R, Drennan CL. Creating an interdisciplinary introductory chemistry course without time-intensive curriculum changes. Acs Chemical Biology. 4: 979-82. PMID 20017574 DOI: 10.1021/cb9002927  1
2009 Kulik HJ, Blasiak LC, Marzari N, Drennan CL. First-principles study of non-heme Fe(II) halogenase SyrB2 reactivity. Journal of the American Chemical Society. 131: 14426-33. PMID 19807187 DOI: 10.1021/ja905206k  1
2009 Drennan CL, Jarrett JT. From single molecules to whole organisms: the evolving field of mechanistic enzymology. Current Opinion in Chemical Biology. 13: 433-5. PMID 19740697 DOI: 10.1016/j.cbpa.2009.08.004  1
2009 Phillips CM, Nerenberg PS, Drennan CL, Stultz CM. Physical basis of metal-binding specificity in Escherichia coli NikR. Journal of the American Chemical Society. 131: 10220-8. PMID 19621966 DOI: 10.1021/ja9026314  1
2009 Kung Y, Doukov TI, Seravalli J, Ragsdale SW, Drennan CL. Crystallographic snapshots of cyanide- and water-bound C-clusters from bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Biochemistry. 48: 7432-40. PMID 19583207 DOI: 10.1021/bi900574h  1
2009 Ryan KS, Drennan CL. Divergent pathways in the biosynthesis of bisindole natural products. Chemistry & Biology. 16: 351-64. PMID 19389622 DOI: 10.1016/j.chembiol.2009.01.017  1
2009 Wong C, Fujimori DG, Walsh CT, Drennan CL. Structural analysis of an open active site conformation of nonheme iron halogenase CytC3. Journal of the American Chemical Society. 131: 4872-9. PMID 19281171 DOI: 10.1021/ja8097355  1
2009 Blasiak LC, Drennan CL. Structural perspective on enzymatic halogenation. Accounts of Chemical Research. 42: 147-55. PMID 18774824 DOI: 10.1021/ar800088r  1
2008 Ryan KS, Chakraborty S, Howard-Jones AR, Walsh CT, Ballou DP, Drennan CL. The FAD cofactor of RebC shifts to an IN conformation upon flavin reduction. Biochemistry. 47: 13506-13. PMID 19035832 DOI: 10.1021/bi801229w  1
2008 Vey JL, Yang J, Li M, Broderick WE, Broderick JB, Drennan CL. Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme. Proceedings of the National Academy of Sciences of the United States of America. 105: 16137-41. PMID 18852451 DOI: 10.1073/pnas.0806640105  1
2008 Hamill MJ, Chobot SE, Hernandez HH, Drennan CL, Elliott SJ. Direct electrochemical analyses of a thermophilic thioredoxin reductase: interplay between conformational change and redox chemistry. Biochemistry. 47: 9738-46. PMID 18717594 DOI: 10.1021/bi800676g  1
2008 Hernandez HH, Jaquez OA, Hamill MJ, Elliott SJ, Drennan CL. Thioredoxin reductase from Thermoplasma acidophilum: a new twist on redox regulation. Biochemistry. 47: 9728-37. PMID 18717593 DOI: 10.1021/bi8006753  1
2008 Doukov TI, Blasiak LC, Seravalli J, Ragsdale SW, Drennan CL. Xenon in and at the end of the tunnel of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Biochemistry. 47: 3474-83. PMID 18293927 DOI: 10.1021/bi702386t  1
2008 Phillips CM, Schreiter ER, Guo Y, Wang SC, Zamble DB, Drennan CL. Structural basis of the metal specificity for nickel regulatory protein NikR. Biochemistry. 47: 1938-46. PMID 18193897 DOI: 10.1021/bi702006h  1
2008 Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL. The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins. The Journal of Biological Chemistry. 283: 6467-75. PMID 18171675 DOI: 10.1074/jbc.M708573200  1
2007 Ryan KS, Howard-Jones AR, Hamill MJ, Elliott SJ, Walsh CT, Drennan CL. Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC. Proceedings of the National Academy of Sciences of the United States of America. 104: 15311-6. PMID 17873060 DOI: 10.1073/pnas.0707190104  1
2007 Hubbard PA, Padovani D, Labunska T, Mahlstedt SA, Banerjee R, Drennan CL. Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria. The Journal of Biological Chemistry. 282: 31308-16. PMID 17728257 DOI: 10.1074/jbc.M704850200  1
2007 Taylor EV, Drennan CL. Bringing the excitement of biological research into the chemistry classroom at MIT. Acs Chemical Biology. 2: 515-7. PMID 17708665 DOI: 10.1021/cb700156n  1
2007 Schreiter ER, Drennan CL. Ribbon-helix-helix transcription factors: variations on a theme. Nature Reviews. Microbiology. 5: 710-20. PMID 17676053 DOI: 10.1038/nrmicro1717  1
2007 Chobot SE, Hernandez HH, Drennan CL, Elliott SJ. Direct electrochemical characterization of archaeal thioredoxins. Angewandte Chemie (International Ed. in English). 46: 4145-7. PMID 17443752 DOI: 10.1002/anie.200604620  1
2007 Yeh E, Blasiak LC, Koglin A, Drennan CL, Walsh CT. Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. Biochemistry. 46: 1284-92. PMID 17260957 DOI: 10.1021/bi0621213  1
2007 Frick LE, Delaney JC, Wong C, Drennan CL, Essigmann JM. Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB. Proceedings of the National Academy of Sciences of the United States of America. 104: 755-60. PMID 17213319 DOI: 10.1073/pnas.0607377104  1
2007 Doukov TI, Hemmi H, Drennan CL, Ragsdale SW. Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases. The Journal of Biological Chemistry. 282: 6609-18. PMID 17172470 DOI: 10.1074/jbc.M609828200  1
2007 Drennan CL, Tolman WB. Bioinorganic chemistry. New vistas in bioinorganic chemistry Current Opinion in Chemical Biology. 11: 113-114. DOI: 10.1016/j.cbpa.2007.02.040  1
2007 Ragsdale SW, Kunz RC, Dey M, Seravalli J, Brabec B, Doukov TI, Drennan CL. Nickel enzymes involved in catalyzing the reduction of CO2 to methane and acetic acid Acs National Meeting Book of Abstracts 1
2006 Schreiter ER, Wang SC, Zamble DB, Drennan CL. NikR-operator complex structure and the mechanism of repressor activation by metal ions. Proceedings of the National Academy of Sciences of the United States of America. 103: 13676-81. PMID 16945905 DOI: 10.1073/pnas.0606247103  1
2006 Blasiak LC, Vaillancourt FH, Walsh CT, Drennan CL. Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature. 440: 368-71. PMID 16541079 DOI: 10.1038/nature04544  1
2005 Delaney JC, Smeester L, Wong C, Frick LE, Taghizadeh K, Wishnok JS, Drennan CL, Samson LD, Essigmann JM. AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo. Nature Structural & Molecular Biology. 12: 855-60. PMID 16200073 DOI: 10.1038/nsmb996  1
2005 Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL. Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme. Nature. 437: 838-44. PMID 16015285 DOI: 10.1038/nature03924  1
2005 Andrade SL, Cruz F, Drennan CL, Ramakrishnan V, Rees DC, Ferry JG, Einsle O. Structures of the iron-sulfur flavoproteins from Methanosarcina thermophila and Archaeoglobus fulgidus. Journal of Bacteriology. 187: 3848-54. PMID 15901710 DOI: 10.1128/JB.187.11.3848-3854.2005  1
2004 Berkovitch F, Behshad E, Tang KH, Enns EA, Frey PA, Drennan CL. A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase. Proceedings of the National Academy of Sciences of the United States of America. 101: 15870-5. PMID 15514022 DOI: 10.1073/pnas.0407074101  1
2004 Midelfort KS, Hernandez HH, Lippow SM, Tidor B, Drennan CL, Wittrup KD. Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody. Journal of Molecular Biology. 343: 685-701. PMID 15465055 DOI: 10.1016/j.jmb.2004.08.019  1
2004 Tirupati B, Vey JL, Drennan CL, Bollinger JM. Kinetic and structural characterization of Slr0077/SufS, the essential cysteine desulfurase from Synechocystis sp. PCC 6803. Biochemistry. 43: 12210-9. PMID 15379559 DOI: 10.1021/bi0491447  0.36
2004 Nicolet Y, Drennan CL. AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation. Nucleic Acids Research. 32: 4015-25. PMID 15289575 DOI: 10.1093/nar/gkh728  1
2004 Drennan CL, Doukov TI, Ragsdale SW. The metalloclusters of carbon monoxide dehydrogenase/acetyl-CoA synthase: a story in pictures. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 511-5. PMID 15221484 DOI: 10.1007/s00775-004-0563-y  1
2004 Berkovitch F, Nicolet Y, Wan JT, Jarrett JT, Drennan CL. Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science (New York, N.Y.). 303: 76-9. PMID 14704425 DOI: 10.1126/science.1088493  1
2003 Schreiter ER, Sintchak MD, Guo Y, Chivers PT, Sauer RT, Drennan CL. Crystal structure of the nickel-responsive transcription factor NikR. Nature Structural Biology. 10: 794-9. PMID 12970756 DOI: 10.1038/nsb985  1
2003 Drennan CL, Peters JW. Surprising cofactors in metalloenzymes. Current Opinion in Structural Biology. 13: 220-6. PMID 12727516 DOI: 10.1016/S0959-440X(03)00038-1  1
2002 Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL. A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Science (New York, N.Y.). 298: 567-72. PMID 12386327 DOI: 10.1126/science.1075843  1
2002 Sintchak MD, Arjara G, Kellogg BA, Stubbe J, Drennan CL. The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer. Nature Structural Biology. 9: 293-300. PMID 11875520 DOI: 10.1038/nsb774  1
2001 Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW. Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 98: 11973-8. PMID 11593006 DOI: 10.1073/pnas.211429998  1
2001 Marsh EN, Drennan CL. Adenosylcobalamin-dependent isomerases: new insights into structure and mechanism. Current Opinion in Chemical Biology. 5: 499-505. PMID 11578922 DOI: 10.1016/S1367-5931(00)00238-6  1
1999 Hoover DM, Drennan CL, Metzger AL, Osborne C, Weber CH, Pattridge KA, Ludwig ML. Comparisons of wild-type and mutant flavodoxins from Anacystis nidulans. Structural determinants of the redox potentials. Journal of Molecular Biology. 294: 725-43. PMID 10610792 DOI: 10.1006/jmbi.1999.3152  1
1999 Drennan CL, Pattridge KA, Weber CH, Metzger AL, Hoover DM, Ludwig ML. Refined structures of oxidized flavodoxin from Anacystis nidulans. Journal of Molecular Biology. 294: 711-24. PMID 10610791 DOI: 10.1006/jmbi.1999.3151  1
1998 Drennan CL, Spangler NJ, Ludden PW, Frees DC. Structure determination of carbon monoxide dehydrogenase from rhodqspirillvm rubrum Faseb Journal. 12: A1428.  1
1998 Drennan CL, Farnham P. Career options in biochemistry and molecular biology: A panel discussion Faseb Journal. 12: A1320.  1
1997 Drennan CL, Boyer RF, Hamilton GA, Sokolik CW. How to start and maintain a strong undergraduate biochemistry program: A panel discussion Faseb Journal. 11: A851.  1
1996 Jarrett JT, Drennan CL, Amaratunga M, Scholten JD, Ludwig ML, Matthews RG. A protein radical cage slows photolysis of methylcobalamin in methionine synthase from Escherichia coli. Bioorganic & Medicinal Chemistry. 4: 1237-46. PMID 8879545 DOI: 10.1016/0968-0896(96)00119-8  1
1996 Ludwig ML, Drennan CL, Matthews RG. The reactivity of B12 cofactors: the proteins make a difference. Structure (London, England : 1993). 4: 505-12. PMID 8736549  1
1996 Jarrett JT, Amaratunga M, Drennan CL, Scholten JD, Sands RH, Ludwig ML, Matthews RG. Mutations in the B12-binding region of methionine synthase: how the protein controls methylcobalamin reactivity. Biochemistry. 35: 2464-75. PMID 8652590 DOI: 10.1021/bi952389m  1
1996 Amaratunga M, Fluhr K, Jarrett JT, Drennan CL, Ludwig ML, Matthews RG, Scholten JD. A synthetic module for the metH gene permits facile mutagenesis of the cobalamin-binding region of Escherichia coli methionine synthase: initial characterization of seven mutant proteins. Biochemistry. 35: 2453-63. PMID 8652589 DOI: 10.1021/bi952388u  1
1996 Drennan CL, Matthews RG, Rosenblatt DS, Ledley FD, Fenton WA, Ludwig ML. Molecular basis for dysfunction of some mutant forms of methylmalonyl-CoA mutase: deductions from the structure of methionine synthase. Proceedings of the National Academy of Sciences of the United States of America. 93: 5550-5. PMID 8643613 DOI: 10.1073/pnas.93.11.5550  1
1996 Drennan CL. Cobalamin-dependent methionine synthase: piecing together the structure of a large enzyme Faseb Journal. 10: A1112.  1
1996 Jarrett JT, Hoover DM, Drennan CL, Ludwig ML, Matthews BG. Protein residues control methylcobalamin reactivity in methionine synthase Faseb Journal. 10: A968.  1
1994 Drennan CL, Huang S, Drummond JT, Matthews RG, Lidwig ML. How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase. Science (New York, N.Y.). 266: 1669-74. PMID 7992050  1
1994 Drennan CL, Matthews RG, Ludwig ML. Cobalamin-dependent methionine synthase: the structure of a methylcobalamin-binding fragment and implications for other B12-dependent enzymes. Current Opinion in Structural Biology. 4: 919-29. PMID 7712296 DOI: 10.1016/0959-440X(94)90275-5  1
Show low-probability matches.