| Year |
Citation |
Score |
| 2016 |
Spindler SR, Mote PL, Flegal JM. Combined statin and angiotensin-converting enzyme (ACE) inhibitor treatment increases the lifespan of long-lived F1 male mice. Age (Dordrecht, Netherlands). PMID 27590905 DOI: 10.1007/S11357-016-9948-4 |
0.347 |
|
| 2015 |
Victoria B, Dhahbi JM, Nunez Lopez YO, Spinel L, Atamna H, Spindler SR, Masternak MM. Circulating microRNA signature of genotype-by-age interactions in the long-lived Ames dwarf mouse. Aging Cell. PMID 26176567 DOI: 10.1111/Acel.12373 |
0.338 |
|
| 2015 |
Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, ... ... Spindler SR, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 14: 497-510. PMID 25902704 DOI: 10.1111/Acel.12338 |
0.324 |
|
| 2015 |
Spindler SR, Mote PL, Lublin AL, Flegal JM, Dhahbi JM, Li R. Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 70: 1479-89. PMID 25380600 DOI: 10.1093/Gerona/Glu190 |
0.371 |
|
| 2014 |
Spindler SR, Mote PL, Flegal JM. Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice. Age (Dordrecht, Netherlands). 36: 705-18. PMID 24370781 DOI: 10.1007/S11357-013-9609-9 |
0.329 |
|
| 2013 |
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, ... ... Spindler SR, et al. Metformin improves healthspan and lifespan in mice. Nature Communications. 4: 2192. PMID 23900241 DOI: 10.1038/Ncomms3192 |
0.376 |
|
| 2013 |
Dhahbi JM, Spindler SR, Atamna H, Yamakawa A, Boffelli D, Mote P, Martin DI. 5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction. Bmc Genomics. 14: 298. PMID 23638709 DOI: 10.1186/1471-2164-14-298 |
0.321 |
|
| 2013 |
Spindler SR, Mote PL, Flegal JM, Teter B. Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice. Rejuvenation Research. 16: 143-51. PMID 23432089 DOI: 10.1089/Rej.2012.1386 |
0.368 |
|
| 2013 |
Spindler SR, Mote PL, Li R, Dhahbi JM, Yamakawa A, Flegal JM, Jeske DR, Li R, Lublin AL. β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice. Age (Dordrecht, Netherlands). 35: 2099-109. PMID 23314750 DOI: 10.1007/S11357-012-9498-3 |
0.347 |
|
| 2012 |
Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams RT, Wang Y, Ablao KP. Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. Plos One. 7: e39581. PMID 22737247 DOI: 10.1371/Journal.Pone.0039581 |
0.332 |
|
| 2012 |
Dhahbi JM, Atamna H, Boffelli D, Martin DI, Spindler SR. mRNA-Seq reveals complex patterns of gene regulation and expression in the mouse skeletal muscle transcriptome associated with calorie restriction. Physiological Genomics. 44: 331-44. PMID 22274562 DOI: 10.1152/Physiolgenomics.00129.2011 |
0.318 |
|
| 2012 |
Spindler SR. Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span. Age (Dordrecht, Netherlands). 34: 111-20. PMID 21424790 DOI: 10.1007/S11357-011-9224-6 |
0.304 |
|
| 2010 |
Chiba T, Tsuchiya T, Komatsu T, Mori R, Hayashi H, Shimano H, Spindler SR, Shimokawa I. Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction. Biochemical and Biophysical Research Communications. 401: 213-8. PMID 20846506 DOI: 10.1016/J.Bbrc.2010.09.032 |
0.43 |
|
| 2010 |
Spindler SR. Caloric restriction: from soup to nuts. Ageing Research Reviews. 9: 324-53. PMID 19853062 DOI: 10.1016/J.Arr.2009.10.003 |
0.423 |
|
| 2008 |
Schumacher B, van der Pluijm I, Moorhouse MJ, Kosteas T, Robinson AR, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JH, van der Horst GT, Garinis GA. Delayed and accelerated aging share common longevity assurance mechanisms. Plos Genetics. 4: e1000161. PMID 18704162 DOI: 10.1371/Journal.Pgen.1000161 |
0.417 |
|
| 2007 |
Spindler SR, Mote PL. Screening candidate longevity therapeutics using gene-expression arrays. Gerontology. 53: 306-21. PMID 17570924 DOI: 10.1159/000103924 |
0.381 |
|
| 2007 |
Spindler SR, Dhahbi JM. Conserved and tissue-specific genic and physiologic responses to caloric restriction and altered IGFI signaling in mitotic and postmitotic tissues. Annual Review of Nutrition. 27: 193-217. PMID 17428180 DOI: 10.1146/Annurev.Nutr.27.061406.093743 |
0.352 |
|
| 2006 |
Dhahbi JM, Tsuchiya T, Kim HJ, Mote PL, Spindler SR. Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 61: 218-31. PMID 16567370 DOI: 10.1093/Gerona/61.3.218 |
0.431 |
|
| 2006 |
Spindler SR. Use of microarray biomarkers to identify longevity therapeutics. Aging Cell. 5: 39-50. PMID 16441842 DOI: 10.1111/J.1474-9726.2006.00194.X |
0.436 |
|
| 2005 |
Dhahbi JM, Mote PL, Fahy GM, Spindler SR. Identification of potential caloric restriction mimetics by microarray profiling. Physiological Genomics. 23: 343-50. PMID 16189280 DOI: 10.1152/Physiolgenomics.00069.2005 |
0.315 |
|
| 2005 |
Spindler SR. Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. Mechanisms of Ageing and Development. 126: 960-6. PMID 15927235 DOI: 10.1016/J.Mad.2005.03.016 |
0.377 |
|
| 2004 |
Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR. Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proceedings of the National Academy of Sciences of the United States of America. 101: 5524-9. PMID 15044709 DOI: 10.1073/Pnas.0305300101 |
0.427 |
|
| 2004 |
Tsuchiya T, Dhahbi JM, Cui X, Mote PL, Bartke A, Spindler SR. Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiological Genomics. 17: 307-15. PMID 15039484 DOI: 10.1152/Physiolgenomics.00039.2004 |
0.419 |
|
| 2003 |
Spindler SR, Dhahbi JM, Mote PL. Protein turnover, energy metabolism, aging, and caloric restriction Advances in Cell Aging and Gerontology. 14: 69-86. DOI: 10.1016/S1566-3124(03)14004-7 |
0.413 |
|
| 2002 |
Dhahbi JM, Cao SX, Mote PL, Rowley BC, Wingo JE, Spindler SR. Postprandial induction of chaperone gene expression is rapid in mice. The Journal of Nutrition. 132: 31-7. PMID 11773504 DOI: 10.1093/Jn/132.1.31 |
0.399 |
|
| 2001 |
Weindruch R, Keenan KP, Carney JM, Fernandes G, Feuers RJ, Floyd RA, Halter JB, Ramsey JJ, Richardson A, Roth GS, Spindler SR. Caloric restriction mimetics: metabolic interventions. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 56: 20-33. PMID 12088209 DOI: 10.1093/Gerona/56.Suppl_1.20 |
0.343 |
|
| 2001 |
Spindler SR. Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging. Annals of the New York Academy of Sciences. 928: 296-304. PMID 11795521 DOI: 10.1111/J.1749-6632.2001.Tb05659.X |
0.445 |
|
| 2001 |
Cao SX, Dhahbi JM, Mote PL, Spindler SR. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 10630-5. PMID 11535822 DOI: 10.1073/Pnas.191313598 |
0.428 |
|
| 2001 |
Dhahbi JM, Cao SX, Tillman JB, Mote PL, Madore M, Walford RL, Spindler SR. Chaperone-mediated regulation of hepatic protein secretion by caloric restriction. Biochemical and Biophysical Research Communications. 284: 335-9. PMID 11394882 DOI: 10.1006/Bbrc.2001.4972 |
0.37 |
|
| 2001 |
Dhahbi JM, Mote PL, Wingo J, Rowley BC, Cao SX, Walford RL, Spindler SR. Caloric restriction alters the feeding response of key metabolic enzyme genes. Mechanisms of Ageing and Development. 122: 1033-48. PMID 11389922 DOI: 10.1016/S0047-6374(01)00230-5 |
0.424 |
|
| 1999 |
Dhahbi JM, Mote PL, Wingo J, Tillman JB, Walford RL, Spindler SR. Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. The American Journal of Physiology. 277: E352-60. PMID 10444432 DOI: 10.1152/Ajpendo.1999.277.2.E352 |
0.348 |
|
| 1998 |
Dhahbi JM, Tillman JB, Cao S, Mote PL, Walford RL, Spindler SR. Caloric intake alters the efficiency of catalase mRNA translation in the liver of old female mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 53: B180-5. PMID 9597041 DOI: 10.1093/Gerona/53A.3.B180 |
0.377 |
|
| 1997 |
Dhahbi JM, Mote PL, Tillman JB, Walford RL, Spindler SR. Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice. The Journal of Nutrition. 127: 1758-64. PMID 9278556 DOI: 10.1093/Jn/127.9.1758 |
0.405 |
|
| 1997 |
Walford RL, Spindler SR. The response to calorie restriction in mammals shows features also common to hibernation: a cross-adaptation hypothesis. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 52: B179-83. PMID 9224421 DOI: 10.1093/Gerona/52A.4.B179 |
0.32 |
|
| 1996 |
Tillman JB, Mote PL, Dhahbi JM, Walford RL, Spindler SR. Dietary energy restriction in mice negatively regulates hepatic glucose-regulated protein 78 (GRP78) expression at the posttranscriptional level. The Journal of Nutrition. 126: 416-23. PMID 8632214 DOI: 10.1093/Jn/126.2.416 |
0.407 |
|
| 1996 |
Tillman JB, Dhahbi JM, Mote PL, Walford RL, Spindler SR. Dietary calorie restriction in mice induces carbamyl phosphate synthetase I gene transcription tissue specifically. The Journal of Biological Chemistry. 271: 3500-6. PMID 8631954 DOI: 10.1074/Jbc.271.7.3500 |
0.434 |
|
| 1995 |
Tillman JB, Mote PL, Walford RL, Spindler SR. Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore. Gene. 158: 225-9. PMID 7607546 DOI: 10.1016/0378-1119(95)00083-I |
0.365 |
|
| 1991 |
Mote PL, Grizzle JM, Walford RL, Spindler SR. Influence of age and caloric restriction on expression of hepatic genes for xenobiotic and oxygen metabolizing enzymes in the mouse. Journal of Gerontology. 46: B95-100. PMID 2030268 DOI: 10.1093/Geronj/46.3.B95 |
0.428 |
|
| 1991 |
Mote PL, Grizzle JM, Walford RL, Spindler SR. Aging alters hepatic expression of insulin receptor and c-jun mRNA in the mouse. Mutation Research. 256: 7-12. PMID 1944389 DOI: 10.1016/0921-8734(91)90027-9 |
0.421 |
|
| 1991 |
Spindler SR, Grizzle JM, Walford RL, Mote PL. Aging and restriction of dietary calories increases insulin receptor mRNA, and aging increases glucocorticoid receptor mRNA in the liver of female C3B10RF1 mice. Journal of Gerontology. 46: B233-7. PMID 1940074 DOI: 10.1093/Geronj/46.6.B233 |
0.404 |
|
| 1990 |
Spindler SR, Crew MD, Mote PL, Grizzle JM, Walford RL. Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA. The Journal of Nutrition. 120: 1412-7. PMID 2231029 DOI: 10.1093/Jn/120.11.1412 |
0.403 |
|
| 1990 |
Mote PL, Grizzle JM, Walford RL, Spindler SR. Age-related down regulation of hepatic cytochrome P1-450, P3-450, catalase and CuZn-superoxide dismutase RNA. Mechanisms of Ageing and Development. 53: 101-10. PMID 1691420 DOI: 10.1016/0047-6374(90)90038-H |
0.373 |
|
| 1989 |
Spindler SR, Crew MD, Nyborg JK. Thyroid hormone transcriptional regulatory region of the growth hormone gene. Endocrine Research. 15: 475-93. PMID 2699451 DOI: 10.3109/07435808909036349 |
0.305 |
|
| 1989 |
Spindler SR, Koizumi A, Walford RL, Mote PL. P1-450 and P3-450 gene expression and maximum life span in mice. Mutation Research. 219: 89-94. PMID 2538732 DOI: 10.1016/0921-8734(89)90018-0 |
0.307 |
|
| 1987 |
Crew MD, Spindler SR, Walford RL, Koizumi A. Age-related decrease of growth hormone and prolactin gene expression in the mouse pituitary. Endocrinology. 121: 1251-5. PMID 3653026 DOI: 10.1210/Endo-121-4-1251 |
0.384 |
|
| 1985 |
Nyborg JK, Nguyen AP, Spindler SR. Cyclic regulation of growth hormone gene transcription in vivo and in vitro. Endocrinology. 116: 2361-5. PMID 3996318 DOI: 10.1210/Endo-116-6-2361 |
0.316 |
|
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