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Matthew D. Shoulders - Publications

Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
proteome repair

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hendel SJ, Shoulders MD. Directed evolution in mammalian cells. Nature Methods. 18: 346-357. PMID 33828274 DOI: 10.1038/s41592-021-01090-x  1
2021 Li RC, Wong MY, DiChiara AS, Hosseini AS, Shoulders MD. Collagen's enigmatic, highly conserved -glycan has an essential proteostatic function. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33674390 DOI: 10.1073/pnas.2026608118  1
2020 Nekongo EE, Ponomarenko AI, Dewal MB, Butty VL, Browne EP, Shoulders MD. HSF1 Activation Can Restrict HIV Replication. Acs Infectious Diseases. PMID 32502335 DOI: 10.1021/Acsinfecdis.0C00166  1
2020 Doan ND, Hosseini AS, Bikovtseva AA, Huang MS, DiChiara AS, Papa LJ, Koller A, Shoulders MD. Elucidation of proteostasis defects caused by osteogenesis imperfecta mutations in the collagen-α2(I) C-propeptide domain. The Journal of Biological Chemistry. PMID 32482890 DOI: 10.1074/Jbc.Ra120.014071  1
2020 Sebastian RM, Shoulders MD. Chemical Biology Framework to Illuminate Proteostasis. Annual Review of Biochemistry. PMID 32097570 DOI: 10.1146/Annurev-Biochem-013118-111552  0.6
2019 Papa LJ, Shoulders MD. Genetic Engineering by DNA Recombineering. Current Protocols in Chemical Biology. 11: e70. PMID 31483098 DOI: 10.1002/Cpch.70  1
2019 Wong MY, Shoulders MD. Targeting defective proteostasis in the collagenopathies. Current Opinion in Chemical Biology. 50: 80-88. PMID 31028939 DOI: 10.1016/J.Cbpa.2019.02.021  1
2019 Doan ND, DiChiara AS, Del Rosario AM, Schiavoni RP, Shoulders MD. Mass Spectrometry-Based Proteomics to Define Intracellular Collagen Interactomes. Methods in Molecular Biology (Clifton, N.J.). 1944: 95-114. PMID 30840237 DOI: 10.1007/978-1-4939-9095-5_7  1
2019 Liebelt F, Sebastian RM, Moore CL, Mulder MPC, Ovaa H, Shoulders MD, Vertegaal ACO. SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock. Cell Reports. 26: 236-249.e4. PMID 30605679 DOI: 10.1016/J.Celrep.2018.12.027  1
2018 Berman C, Papa LJ, Hendel SJ, Moore CL, Suen PH, Weickhardt AF, Doan ND, Kumar CM, Uil TG, Butty VL, Hoeben RC, Shoulders MD. An Adaptable Platform for Directed Evolution in Human Cells. Journal of the American Chemical Society. PMID 30427676 DOI: 10.1021/Jacs.8B10937  1
2018 Richardson CER, Nolan EM, Shoulders MD, Lippard SJ. A sensitive, non-radioactive assay for Zn(II) uptake into metazoan cells. Biochemistry. PMID 30381945 DOI: 10.1021/Acs.Biochem.8B01043  1
2018 DiChiara AS, Li RC, Suen PH, Hosseini AS, Taylor RJ, Weickhardt AF, Malhotra D, McCaslin DR, Shoulders MD. A cysteine-based molecular code informs collagen C-propeptide assembly. Nature Communications. 9: 4206. PMID 30310058 DOI: 10.1038/S41467-018-06185-2  1
2018 Wong MY, Chen K, Antonopoulos A, Kasper BT, Dewal MB, Taylor RJ, Whittaker CA, Hein PP, Dell A, Genereux JC, Haslam SM, Mahal LK, Shoulders MD. XBP1s activation can globally remodel N-glycan structure distribution patterns. Proceedings of the National Academy of Sciences of the United States of America. PMID 30305426 DOI: 10.1073/Pnas.1805425115  1
2018 Phillips AM, Ponomarenko AI, Chen K, Ashenberg O, Miao J, McHugh SM, Butty VL, Whittaker CA, Moore CL, Bloom JD, Lin YS, Shoulders MD. Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones. Plos Biology. 16: e3000008. PMID 30222731 DOI: 10.1371/Journal.Pbio.3000008  1
2018 Phillips AM, Doud MB, Gonzalez LO, Butty VL, Lin YS, Bloom JD, Shoulders MD. Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin. Elife. 7. PMID 30188321 DOI: 10.7554/Elife.38795  1
2018 Moore CL, Papa LJ, Shoulders MD. A Processive Protein Chimera Introduces Mutations Across Defined DNA Regions in vivo. Journal of the American Chemical Society. PMID 29991261 DOI: 10.1021/Jacs.8B04001  1
2018 Wong MY, Doan ND, DiChiara AS, Papa LJ, Cheah JH, Soule CK, Watson N, Hulleman JD, Shoulders MD. High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production. Biochemistry. PMID 29676157 DOI: 10.1021/Acs.Biochem.8B00378  1
2018 Cole KS, Grandjean JMD, Chen K, Witt CH, O'Day J, Shoulders MD, Wiseman RL, Weerapana E. Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor. Biochemistry. PMID 29521097 DOI: 10.1021/Acs.Biochem.8B00178  1
2018 Richardson CER, Cunden LS, Butty VL, Nolan EM, Lippard SJ, Shoulders MD. A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency. Journal of the American Chemical Society. PMID 29334734 DOI: 10.1021/Jacs.7B12897  1
2017 Phillips AM, Gonzalez LO, Nekongo EE, Ponomarenko AI, McHugh SM, Butty VL, Levine SS, Lin YS, Mirny LA, Shoulders MD. Host proteostasis modulates influenza evolution. Elife. 6. PMID 28949290 DOI: 10.7554/Elife.28652  1
2017 Wong MY, DiChiara AS, Suen PH, Chen K, Doan ND, Shoulders MD. Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response. Current Topics in Microbiology and Immunology. PMID 28929194 DOI: 10.1007/82_2017_56  1
2016 Maji B, Moore CL, Zetsche B, Volz SE, Zhang F, Shoulders MD, Choudhary A. Multidimensional chemical control of CRISPR-Cas9. Nature Chemical Biology. PMID 27820801 DOI: 10.1038/Nchembio.2224  1
2016 DiChiara AS, Taylor RJ, Wong MY, Doan ND, Del Rosario AM, Shoulders MD. Mapping and Exploring the Collagen-I Proteostasis Network. Acs Chemical Biology. PMID 26848503 DOI: 10.1021/Acschembio.5B01083  1
2015 Phillips AM, Shoulders MD. The Path of Least Resistance: Mechanisms to Reduce Influenza's Sensitivity to Oseltamivir. Journal of Molecular Biology. PMID 26748011 DOI: 10.1016/J.Jmb.2015.12.019  1
2015 Moore CL, Dewal MB, Nekongo EE, Santiago S, Lu NB, Levine SS, Shoulders MD. Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1. Acs Chemical Biology. PMID 26502114 DOI: 10.1021/Acschembio.5B00740  1
2015 Dewal MB, DiChiara AS, Antonopoulos A, Taylor RJ, Harmon CJ, Haslam SM, Dell A, Shoulders MD. XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans. Chemistry & Biology. 22: 1301-12. PMID 26496683 DOI: 10.1016/J.Chembiol.2015.09.006  1
2015 Choudhary A, Kamer KJ, Shoulders MD, Raines RT. 4-ketoproline: An electrophilic proline analog for bioconjugation. Biopolymers. 104: 110-5. PMID 25656588 DOI: 10.1002/Bip.22620  1
2015 Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. The Embo Journal. 34: 4-19. PMID 25361606 DOI: 10.15252/Embj.201488896  1
2014 Chen JJ, Genereux JC, Qu S, Hulleman JD, Shoulders MD, Wiseman RL. ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein. Chemistry & Biology. 21: 1564-74. PMID 25444553 DOI: 10.1016/J.Chembiol.2014.09.009  1
2014 Ryno LM, Genereux JC, Naito T, Morimoto RI, Powers ET, Shoulders MD, Wiseman RL. Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1. Acs Chemical Biology. 9: 1273-83. PMID 24689980 DOI: 10.1021/Cb500062N  1
2013 Shoulders MD, Ryno LM, Cooley CB, Kelly JW, Wiseman RL. Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells. Journal of the American Chemical Society. 135: 8129-32. PMID 23682758 DOI: 10.1021/Ja402756P  1
2013 Shoulders MD, Ryno LM, Genereux JC, Moresco JJ, Tu PG, Wu C, Yates JR, Su AI, Kelly JW, Wiseman RL. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Reports. 3: 1279-92. PMID 23583182 DOI: 10.1016/J.Celrep.2013.03.024  1
2012 Krow GR, Shoulders MD, Edupuganti R, Gandla D, Yu F, Sonnet PE, Sender M, Choudhary A, DeBrosse C, Ross CW, Carroll P, Raines RT. Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-exo and Cγ-endo Flp and Hyp conformer mimics. The Journal of Organic Chemistry. 77: 5331-44. PMID 22607128 DOI: 10.1021/Jo300700A  1
2011 Krow GR, Edupuganti R, Gandla D, Yu F, Sender M, Sonnet PE, Zdilla MJ, DeBrosse C, Cannon KC, Ross CW, Choudhary A, Shoulders MD, Raines RT. Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines. The Journal of Organic Chemistry. 76: 3626-34. PMID 21500838 DOI: 10.1021/Jo200117P  1
2011 Shoulders MD, Raines RT. Interstrand dipole-dipole interactions can stabilize the collagen triple helix. The Journal of Biological Chemistry. 286: 22905-12. PMID 21482820 DOI: 10.1074/Jbc.M110.199984  1
2010 Krow GR, Liu N, Sender M, Lin G, Centafont R, Sonnet PE, DeBrosse C, Ross CW, Carroll PJ, Shoulders MD, Raines RT. Oligomers of a 5-carboxy-methanopyrrolidine β-amino acid. A search for order. Organic Letters. 12: 5438-41. PMID 21043445 DOI: 10.1021/Ol1022917  1
2010 Shoulders MD, Kotch FW, Choudhary A, Guzei IA, Raines RT. The aberrance of the 4S diastereomer of 4-hydroxyproline. Journal of the American Chemical Society. 132: 10857-65. PMID 20681719 DOI: 10.1021/Ja103082Y  1
2010 Shoulders MD, Satyshur KA, Forest KT, Raines RT. Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proceedings of the National Academy of Sciences of the United States of America. 107: 559-64. PMID 20080719 DOI: 10.1073/Pnas.0909592107  1
2009 Shoulders MD, Kamer KJ, Raines RT. Origin of the stability conferred upon collagen by fluorination. Bioorganic & Medicinal Chemistry Letters. 19: 3859-62. PMID 19423349 DOI: 10.1016/J.Bmcl.2009.03.168  1
2009 Shoulders MD, Raines RT. Modulating collagen triple-helix stability with 4-chloro, 4-fluoro, and 4-methylprolines. Advances in Experimental Medicine and Biology. 611: 251-2. PMID 19400182 DOI: 10.1007/978-0-387-73657-0_115  1
2009 Shoulders MD, Raines RT. Collagen structure and stability. Annual Review of Biochemistry. 78: 929-58. PMID 19344236 DOI: 10.1146/Annurev.Biochem.77.032207.120833  1
2008 Shoulders MD, Guzei IA, Raines RT. 4-chloroprolines: synthesis, conformational analysis, and effect on the collagen triple helix. Biopolymers. 89: 443-54. PMID 17937398 DOI: 10.1002/Bip.20864  1
2006 Shoulders MD, Hodges JA, Raines RT. Reciprocity of steric and stereoelectronic effects in the collagen triple helix. Journal of the American Chemical Society. 128: 8112-3. PMID 16787056 DOI: 10.1021/Ja061793D  1
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