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Felicia A. Etzkorn, Ph.D. - Publications

Affiliations: 
1993-2000 Chemistry University of Virginia, Charlottesville, VA 
 2000- Chemistry Virginia Polytechnic and State University, United States 
Area:
protein structure and enzyme inhibitors by designing and synthesizing conformationally constrained mimics of peptides
Website:
http://www.etzkornlab.chem.vt.edu/

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Chen XR, Fan SA, Ware RI, Etzkorn FA. Stereochemical Control in the Still-Wittig Rearrangement Synthesis of Cyclohexyl (Z)-Alkene Inhibitors of Pin1. Plos One. 10: e0139543. PMID 26445009 DOI: 10.1371/journal.pone.0139543  1
2015 Mayfield JE, Fan S, Wei S, Zhang M, Li B, Ellington AD, Etzkorn FA, Zhang YJ. Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II. Acs Chemical Biology. PMID 26332362 DOI: 10.1021/acschembio.5b00296  1
2015 Etzkorn FA, Zhao S. Stereospecific phosphorylation by the central mitotic kinase Cdk1-cyclin B. Acs Chemical Biology. 10: 952-6. PMID 25603287 DOI: 10.1021/cb500815b  1
2014 Melin VE, Johnstone DW, Etzkorn FA, Hrubec TC. Drinking water treatment is not associated with an observed increase in neural tube defects in mice. Environmental Monitoring and Assessment. 186: 3717-24. PMID 24497082 DOI: 10.1007/s10661-014-3652-6  1
2013 Mercedes-Camacho AY, Mullins AB, Mason MD, Xu GG, Mahoney BJ, Wang X, Peng JW, Etzkorn FA. Kinetic isotope effects support the twisted amide mechanism of Pin1 peptidyl-prolyl isomerase. Biochemistry. 52: 7707-13. PMID 24116866 DOI: 10.1021/bi400700b  1
2013 Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, et al. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell. 154: 637-50. PMID 23911326 DOI: 10.1016/j.cell.2013.07.001  1
2013 Nachman RJ, Wang XJ, Etzkorn FA, Kaczmarek K, Zabrocki J, Lopez J, Coast GM. Evaluation of insect CAP2b analogs with either an (E)-alkene, trans- or a (Z)-alkene, cis-Pro isostere identifies the Pro orientation for antidiuretic activity in the stink bug. Peptides. 41: 101-6. PMID 23036324 DOI: 10.1016/j.peptides.2012.09.026  1
2012 Xu GG, Slebodnick C, Etzkorn FA. Cyclohexyl ketone inhibitors of Pin1 dock in a trans-diaxial cyclohexane conformation. Plos One. 7: e44226. PMID 23028504 DOI: 10.1371/journal.pone.0044226  1
2012 Zhang M, Wang XJ, Chen X, Bowman ME, Luo Y, Noel JP, Ellington AD, Etzkorn FA, Zhang Y. Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. Acs Chemical Biology. 7: 1462-70. PMID 22670809 DOI: 10.1021/cb3000887  1
2012 Tarrant MK, Rho HS, Xie Z, Jiang YL, Gross C, Culhane JC, Yan G, Qian J, Ichikawa Y, Matsuoka T, Zachara N, Etzkorn FA, Hart GW, Jeong JS, Blackshaw S, et al. Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nature Chemical Biology. 8: 262-9. PMID 22267120 DOI: 10.1038/nchembio.771  1
2011 Xu GG, Zhang Y, Mercedes-Camacho AY, Etzkorn FA. A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state. Biochemistry. 50: 9545-50. PMID 21980916 DOI: 10.1021/bi201055c  1
2011 Namanja AT, Wang XJ, Xu B, Mercedes-Camacho AY, Wilson KA, Etzkorn FA, Peng JW. Stereospecific gating of functional motions in Pin1. Proceedings of the National Academy of Sciences of the United States of America. 108: 12289-94. PMID 21746900 DOI: 10.1073/pnas.1019382108  1
2010 Namanja AT, Wang XJ, Xu B, Mercedes-Camacho AY, Wilson BD, Wilson KA, Etzkorn FA, Peng JW. Toward flexibility-activity relationships by NMR spectroscopy: dynamics of Pin1 ligands. Journal of the American Chemical Society. 132: 5607-9. PMID 20356313 DOI: 10.1021/ja9096779  1
2010 Mercedes-Camacho AY, Etzkorn FA. Enzyme-linked enzyme-binding assay for Pin1 WW domain ligands. Analytical Biochemistry. 402: 77-82. PMID 20230769 DOI: 10.1016/j.ab.2010.03.018  1
2010 Xu GG, Etzkorn FA. Convergent synthesis of alpha-ketoamide inhibitors of Pin1. Organic Letters. 12: 696-9. PMID 20102178 DOI: 10.1021/ol9027013  1
2010 Etzkorn F. Mail: Earmark science Scientist. 24.  1
2009 Xu GG, Etzkorn FA. Pin1 as an anticancer drug target. Drug News & Perspectives. 22: 399-407. PMID 19890497 DOI: 10.1358/dnp.2009.22.7.1381751  1
2009 Dai N, Etzkorn FA. Cis-trans proline isomerization effects on collagen triple-helix stability are limited. Journal of the American Chemical Society. 131: 13728-32. PMID 19725497 DOI: 10.1021/ja904177k  1
2009 Nachman RJ, Wang XJ, Etzkorn FA, Aziz OB, Davidovitch M, Kaczmarek K, Zabrocki J, Strey A, Pryor N, Altstein M. Evaluation of a PK/PBAN analog with an (E)-alkene, trans-Pro isostere identifies the Pro orientation for activity in four diverse PK/PBAN bioassays. Peptides. 30: 1254-9. PMID 19416747 DOI: 10.1016/j.peptides.2009.04.017  1
2009 Nachman RJ, Kim YJ, Wang XJ, Etzkorn FA, Kaczmarek K, Zabrocki J, Adams ME. Potent activity of a PK/PBAN analog with an (E)-alkene, trans-Pro mimic identifies the Pro orientation and core conformation during interaction with HevPBANR-C receptor. Bioorganic & Medicinal Chemistry. 17: 4216-20. PMID 19356938 DOI: 10.1016/j.bmc.2009.03.036  1
2008 Dai N, Wang XJ, Etzkorn FA. The effect of a trans-locked Gly-Pro alkene isostere on collagen triple helix stability. Journal of the American Chemical Society. 130: 5396-7. PMID 18366169 DOI: 10.1021/ja711021m  1
2007 Zhao S, Etzkorn FA. A phosphorylated prodrug for the inhibition of Pin1. Bioorganic & Medicinal Chemistry Letters. 17: 6615-8. PMID 17935986 DOI: 10.1016/j.bmcl.2007.09.073  1
2007 Liu T, Kapustin G, Etzkorn FA. Design and synthesis of a potent histone deacetylase inhibitor. Journal of Medicinal Chemistry. 50: 2003-6. PMID 17419603 DOI: 10.1021/jm061082q  1
2006 Etzkorn FA. Pin1 flips Alzheimer's switch. Acs Chemical Biology. 1: 214-6. PMID 17163675 DOI: 10.1021/cb600171g  1
2006 Schroeder OE, Carper E, Wind JJ, Poutsma JL, Etzkorn FA, Poutsma JC. Theoretical and experimental investigation of the energetics of cis-trans proline isomerization in peptide models. The Journal of Physical Chemistry. A. 110: 6522-30. PMID 16706410 DOI: 10.1021/jp060642u  1
2006 Wang XJ, Etzkorn FA. Peptidyl-prolyl isomerase inhibitors. Biopolymers. 84: 125-46. PMID 16302169 DOI: 10.1002/bip.20240  1
2006 Etzkorn F. A nasty mother [2] Scientist. 20: 14.  1
2004 Wang XJ, Xu B, Mullins AB, Neiler FK, Etzkorn FA. Conformationally locked isostere of phosphoSer-cis-Pro inhibits Pin1 23-fold better than phosphoSer-trans-Pro isostere. Journal of the American Chemical Society. 126: 15533-42. PMID 15563182 DOI: 10.1021/ja046396m  1
2003 Kapustin GV, Fejér G, Gronlund JL, McCafferty DG, Seto E, Etzkorn FA. Phosphorus-based SAHA analogues as histone deacetylase inhibitors. Organic Letters. 5: 3053-6. PMID 12916979 DOI: 10.1021/ol035056n  1
2003 Wang XJ, Hart SA, Xu B, Mason MD, Goodell JR, Etzkorn FA. Serine-cis-proline and serine-trans-proline isosteres: stereoselective synthesis of (Z)- and (E)-alkene mimics by Still-Wittig and Ireland-Claisen rearrangements. The Journal of Organic Chemistry. 68: 2343-9. PMID 12636401 DOI: 10.1021/jo026663b  1
2001 Hart SA, Trindle CO, Etzkorn FA. Solvent-dependent stereoselectivity in a Still-Wittig rearrangement: an experimental and ab initio study. Organic Letters. 3: 1789-91. PMID 11405712 DOI: 10.1021/ol015764d  1
2001 Foulds GJ, Etzkorn FA. Protein-DNA binding affinities by capillary electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 163: 369-78. PMID 11242960 DOI: 10.1385/1-59259-116-7:369  1
2000 Etzkorn FA, Travins JM. Stereoselective deuterium labeling of proR beta-protons in the NMR structure determination of a helix-turn-helix turn peptide mimic. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 436-46. PMID 10888200 DOI: 10.1034/j.1399-3011.2000.00710.x  1
1999 Hart SA, Etzkorn FA. Cyclophilin Inhibition by a (Z)-Alkene cis-Proline Mimic. The Journal of Organic Chemistry. 64: 2998-2999. PMID 11674392 DOI: 10.1021/jo990409a  1
1999 Foulds GJ, Etzkorn FA. DNA-binding affinities of MyoD and E47 homo- and hetero-dimers by capillary electrophoresis mobility shift assay. Journal of Chromatography. A. 862: 231-6. PMID 10596981 DOI: 10.1016/S0021-9673(99)00923-1  1
1998 Foulds GJ, Etzkorn FA. A capillary electrophoresis mobility shift assay for protein-DNA binding affinities free in solution. Nucleic Acids Research. 26: 4304-5. PMID 9722653 DOI: 10.1093/nar/26.18.4304  1
1998 Travins JM, Etzkorn FA. Facile synthesis of D-amino acids from an L-serine-derived aziridine Tetrahedron Letters. 39: 9389-9392.  1
1998 Hart SA, Sabat M, Etzkorn FA. Enantio- And Regioselective Synthesis of a (Z)-Alkene czs-Proline Mimic Journal of Organic Chemistry. 63: 7580-7581.  1
1997 Travins JM, Etzkorn FA. Design and Enantioselective Synthesis of a Peptidomimetic of the Turn in the Helix-Turn-Helix DNA-Binding Protein Motif. The Journal of Organic Chemistry. 62: 8387-8393. PMID 11671976  1
1994 Fejzo J, Etzkorn FA, Clubb RT, Shi Y, Walsh CT, Wagner G. The mutant Escherichia coli F112W cyclophilin binds cyclosporin A in nearly identical conformation as human cyclophilin. Biochemistry. 33: 5711-20. PMID 8180197 DOI: 10.1021/bi00185a007  1
1994 Etzkorn FA, Chang ZY, Stolz LA, Walsh CT. Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the cyclophilin.cyclosporin A complex. Biochemistry. 33: 2380-8. PMID 8117697  1
1994 Ke H, Mayrose D, Belshaw PJ, Alberg DG, Schreiber SL, Chang ZY, Etzkorn FA, Ho S, Walsh CT. Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. Structure (London, England : 1993). 2: 33-44. PMID 8075981 DOI: 10.1016/S0969-2126(00)00006-X  1
1994 Etzkorn FA, Guo T, Lipton MA, Goldberg SD, Bartlett PA. Cyclic hexapeptides and chimeric peptides as mimics of tendamistat Journal of the American Chemical Society. 116: 10412-10425. DOI: 10.1021/ja00102a008  1
1994 Wiederrecht G, Etzkorn F. The immunophilins Perspectives in Drug Discovery and Design. 2: 57-84. DOI: 10.1007/BF02171737  1
1993 Benson TE, Marquardt JL, Marquardt AC, Etzkorn FA, Walsh CT. Overexpression, purification, and mechanistic study of UDP-N-acetylenolpyruvylglucosamine reductase. Biochemistry. 32: 2024-30. PMID 8448160  1
1993 Etzkorn FA, Stolz LA, Chang Z, Walsh CT. Role of the cyclosporin-A-cyclophilin complex, FK506-FK506-binding protein complex and calcineurin in the inhibition of T-cell signal transduction. Current opinion in structural biology 1993, 3:929-933 Current Opinion in Structural Biology. 3: 929-933. DOI: 10.1016/0959-440X(93)90158-H  1
1992 Zydowsky LD, Etzkorn FA, Chang HY, Ferguson SB, Stolz LA, Ho SI, Walsh CT. Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition. Protein Science : a Publication of the Protein Society. 1: 1092-9. PMID 1338979 DOI: 10.1002/pro.5560010903  1
1992 Maier WF, Etzkorn FA. Indications to a Thermodynamic Control of the Relative Rate of Hydrogenation on Platinum | Hinweise zur thermodynamischen Kontrolle von relativen Hydriergeschwindigkeiten an Platin Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences. 47: 175-178. DOI: 10.1515/znb-1992-0204  1
1980 Briggs RW, Etzkorn FA, Hinton JF. 205Tl nuclear magnetic resonance study of the thallium complex of lasalocid (X-537A) Journal of Magnetic Resonance (1969). 37: 523-528. DOI: 10.1016/0022-2364(80)90057-8  0.4
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