Hendrik Luesch - Publications

Affiliations: 
University of Florida, Gainesville, Gainesville, FL, United States 

128 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bousquet MS, Ratnayake R, Pope JL, Chen QY, Zhu F, Chen S, Carney TJ, Gharaibeh RZ, Jobin C, Paul VJ, Luesch H. Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression. Free Radical Biology & Medicine. PMID 31536771 DOI: 10.1016/j.freeradbiomed.2019.09.013  1
2019 Liang X, Matthew S, Chen QY, Kwan JC, Paul VJ, Luesch H. Discovery and Total Synthesis of Doscadenamide A: A Quorum Sensing Signaling Molecule from a Marine Cyanobacterium. Organic Letters. PMID 31414826 DOI: 10.1021/acs.orglett.9b02525  1
2019 Qiu B, Tan A, Veluchamy AB, Li Y, Murray H, Cheng W, Liu C, Busoy JM, Chen QY, Sistla S, Hunziker W, Cheung CMG, Wong TY, Hong W, Luesch H, et al. Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases. Investigative Ophthalmology & Visual Science. 60: 3254-3263. PMID 31361305 DOI: 10.1167/iovs.19-26936  1
2019 Liang X, Luo D, Luesch H. Advances in Exploring the Therapeutic Potential of Marine Natural Products. Pharmacological Research. 104373. PMID 31351913 DOI: 10.1016/j.phrs.2019.104373  1
2019 Liang X, Luo D, Yan JL, Rezaei MA, Salvador-Reyes LA, Gunasekera SP, Li C, Ye T, Paul VJ, Luesch H. Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria. Organic Letters. PMID 30779584 DOI: 10.1021/acs.orglett.9b00163  1
2019 Luo D, Putra MY, Ye T, Paul VJ, Luesch H. Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria. Marine Drugs. 17. PMID 30717076 DOI: 10.3390/md17020083  1
2019 Gunasekera SP, Meyer JL, Ding Y, Abboud KA, Luo D, Campbell JE, Angerhofer A, Goodsell JL, Raymundo LJ, Liu J, Ye T, Luesch H, Teplitski M, Paul VJ. Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles. Journal of Natural Products. PMID 30636420 DOI: 10.1021/acs.jnatprod.8b00804  1
2018 Brumley D, Spencer KA, Gunasekera SP, Sauvage T, Biggs J, Paul VJ, Luesch H. Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales). Journal of Natural Products. PMID 30489078 DOI: 10.1021/acs.jnatprod.8b00650  0.92
2018 Jonus HC, Hanberry BS, Khatu S, Kim J, Luesch H, Dang LH, Bartlett MG, Zastre JA. The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions. Oncotarget. 9: 35422-35438. PMID 30459934 DOI: 10.18632/oncotarget.26259  0.84
2018 Yan JL, Cheng Y, Chen J, Ratnayake R, Dang LH, Luesch H, Guo Y, Ye T. Total Synthesis of Asperphenins A and B. Organic Letters. PMID 30232896 DOI: 10.1021/acs.orglett.8b02652  0.84
2018 Cai W, Ratnayake R, Gerber MH, Chen QY, Yu Y, Derendorf H, Trevino JG, Luesch H. Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model. Investigational New Drugs. PMID 30073464 DOI: 10.1007/s10637-018-0647-0  1
2018 Al-Awadhi FH, Gao B, Rezaei MA, Kwan JC, Li C, Ye T, Paul VJ, Luesch H. Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium. Journal of Medicinal Chemistry. PMID 30015488 DOI: 10.1021/acs.jmedchem.8b00885  0.96
2018 Garrison AT, Abouelhassan Y, Kallifidas D, Tan H, Kim YS, Jin S, Luesch H, Huigens Iii RW. An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication and Prodrug Exploration. Journal of Medicinal Chemistry. PMID 29638121 DOI: 10.1021/acs.jmedchem.7b01903  0.96
2018 Cai W, Matthew S, Chen QY, Paul VJ, Luesch H. Discovery of new A- and B-type laxaphycins with synergistic anticancer activity. Bioorganic & Medicinal Chemistry. PMID 29606488 DOI: 10.1016/j.bmc.2018.03.022  1
2018 Jiang G, Zhang Y, Powell MM, Zhang P, Zuo R, Zhang Y, Kallifidas D, Tieu AM, Luesch H, Loria R, Ding Y. High-yield production of herbicidal thaxtomins and analogs in a nonpathogenicstrain. Applied and Environmental Microbiology. PMID 29602787 DOI: 10.1128/AEM.00164-18  0.96
2018 Matthews JH, Liang X, Paul VJ, Luesch H. A Complementary Chemical and Genomic Screening Approach for Druggable Targets in the Nrf2 Pathway and Small Molecule Inhibitors to Overcome Cancer Cell Drug Resistance. Acs Chemical Biology. PMID 29565554 DOI: 10.1021/acschembio.7b01025  1
2018 Kallifidas D, Jiang G, Ding Y, Luesch H. Rational engineering of Streptomyces albus J1074 for the overexpression of secondary metabolite gene clusters. Microbial Cell Factories. 17: 25. PMID 29454348 DOI: 10.1186/s12934-018-0874-2  0.96
2018 Al-Awadhi FH, Paul VJ, Luesch H. Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer. Chembiochem : a European Journal of Chemical Biology. PMID 29405541 DOI: 10.1002/cbic.201700627  0.92
2018 Yang G, Cozad MA, Holland DA, Zhang Y, Luesch H, Ding Y. Photosynthetic production of sunscreen shinorine using an engineered cyanobacterium. Acs Synthetic Biology. PMID 29304277 DOI: 10.1021/acssynbio.7b00397  0.96
2017 Cai W, Chen QY, Dang LH, Luesch H. Correction to "Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors". Acs Medicinal Chemistry Letters. 8: 1342. PMID 29266134 DOI: 10.1021/acsmedchemlett.7b00498  1
2017 Matthew S, Schupp PJ, Luesch H. Correction to Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine Cyanobacterium Lyngbya bouillonii. Journal of Natural Products. PMID 29257686 DOI: 10.1021/acs.jnatprod.7b00982  0.92
2017 Cai W, Salvador-Reyes LA, Zhang W, Chen QY, Matthew S, Ratnayake R, Seo SJ, Dolles S, Gibson DJ, Paul VJ, Luesch H. Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. Acs Chemical Biology. PMID 29205032 DOI: 10.1021/acschembio.7b00827  1
2017 Al-Awadhi FH, Law BK, Paul VJ, Luesch H. Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer. Journal of Natural Products. PMID 29087712 DOI: 10.1021/acs.jnatprod.7b00551  0.92
2017 Cai W, Chen QY, Dang LH, Luesch H. Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors. Acs Medicinal Chemistry Letters. 8: 1007-1012. PMID 29057042 DOI: 10.1021/acsmedchemlett.7b00192  1
2017 Alfurhood JA, Sun H, Kabb CP, Tucker BS, Matthews JH, Luesch H, Sumerlin BS. Poly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers. Polymer Chemistry. 8: 4983-4987. PMID 28959359 DOI: 10.1039/C7PY00196G  0.84
2017 Yang G, Zhang Y, Lee NK, Cozad MA, Kearney SE, Luesch H, Ding Y. Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways. Scientific Reports. 7: 11888. PMID 28928426 DOI: 10.1038/s41598-017-12244-3  0.96
2017 Al-Awadhi FH, Salvador LA, Law BK, Paul VJ, Luesch H. Kempopeptin C, a Novel Marine-Derived Serine Protease Inhibitor Targeting Invasive Breast Cancer. Marine Drugs. 15. PMID 28926939 DOI: 10.3390/md15090290  1
2017 Tocco VJ, Li Y, Christopher KG, Matthews JH, Aggarwal V, Paschall L, Luesch H, Licht JD, Dickinson RB, Lele TP. The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells. Journal of Cellular Physiology. PMID 28542912 DOI: 10.1002/jcp.26031  0.84
2017 Yang H, Abouelhassan Y, Burch GM, Kallifidas D, Huang G, Yousaf H, Jin S, Luesch H, Huigens RW. A Highly Potent Class of Halogenated Phenazine Antibacterial and Biofilm-Eradicating Agents Accessed Through a Modular Wohl-Aue Synthesis. Scientific Reports. 7: 2003. PMID 28515440 DOI: 10.1038/s41598-017-01045-3  0.96
2017 Kim B, Ratnayake R, Lee H, Shi G, Zeller SL, Li C, Luesch H, Hong J. Synthesis and biological evaluation of largazole zinc-binding group analogs. Bioorganic & Medicinal Chemistry. PMID 28416100 DOI: 10.1016/j.bmc.2017.03.071  1
2016 Paciaroni N, Ratnayake R, Matthews J, Norwood V, Arnold A, Dang L, Luesch H, Huigens Iii RW. A Tryptoline Ring Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27900785 DOI: 10.1002/chem.201604795  0.84
2016 Wu P, Cai W, Chen QY, Xu S, Yin R, Li Y, Zhang W, Luesch H. Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product. Organic Letters. PMID 27723359 DOI: 10.1021/acs.orglett.6b02780  1
2016 Law ME, Ferreira RB, Davis BJ, Higgins PJ, Kim JS, Castellano RK, Chen S, Luesch H, Law BK. CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment. Breast Cancer Research : Bcr. 18: 80. PMID 27495374 DOI: 10.1186/s13058-016-0741-1  1
2016 Gunasekera SP, Imperial L, Garst C, Ratnayake R, Dang LH, Paul VJ, Luesch H. Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata. Journal of Natural Products. PMID 27380142 DOI: 10.1021/acs.jnatprod.6b00203  0.92
2016 Al-Awadhi FH, Ratnayake R, Paul VJ, Luesch H. Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium. Bioorganic & Medicinal Chemistry. PMID 27211244 DOI: 10.1016/j.bmc.2016.04.062  0.92
2016 Gunasekera SP, Li Y, Ratnayake R, Luo D, Lo J, Reibenspies JH, Xu Z, Clare-Salzler MJ, Ye T, Paul VJ, Luesch H. Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27139508 DOI: 10.1002/chem.201600674  1
2016 Cai W, Matthews JH, Paul VJ, Luesch H. Pitiamides A and B, Multifunctional Fatty Acid Amides from Marine Cyanobacteria. Planta Medica. PMID 27135625 DOI: 10.1055/s-0042-105157  1
2016 Garrison AT, Abouelhassan Y, Norwood VM, Kallifidas D, Bai F, Nguyen MT, Rolfe M, Burch GM, Jin S, Luesch H, Huigens Iii RW. Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines that Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 27018907 DOI: 10.1021/acs.jmedchem.5b02004  1
2016 Bousquet MS, Ma JJ, Ratnayake R, Havre PA, Yao J, Dang NH, Paul VJ, Carney TJ, Dang LH, Luesch H. Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer. Acs Chemical Biology. PMID 26938486 DOI: 10.1021/acschembio.5b00860  0.92
2016 Salvador LA, Paul VJ, Luesch H. Correction to Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida. Journal of Natural Products. PMID 26885760 DOI: 10.1021/acs.jnatprod.6b00120  1
2015 Luo D, Chen QY, Luesch H. Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and in Vitro Biological Evaluation in Model Systems for Pulmonary Diseases. The Journal of Organic Chemistry. PMID 26709602 DOI: 10.1021/acs.joc.5b02386  1
2015 Garrison AT, Abouelhassan Y, Kallifidas D, Bai F, Ukhanova M, Mai V, Jin S, Luesch H, Huigens RW. Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures, and Mycobacterium tuberculosis. Angewandte Chemie (International Ed. in English). PMID 26480852 DOI: 10.1002/anie.201508155  1
2015 Engene N, Tronholm A, Salvador-Reyes LA, Luesch H, Paul VJ. Caldora penicillata gen. nov., comb. nov. (Cyanobacteria), a pantropical marine species with biomedical relevance. Journal of Phycology. 51: 670-681. PMID 26327714 DOI: 10.1111/jpy.12309  0.92
2015 Salvador-Reyes LA, Sneed J, Paul VJ, Luesch H. Amantelides A and B, Polyhydroxylated Macrolides with Differential Broad-Spectrum Cytotoxicity from a Guamanian Marine Cyanobacterium. Journal of Natural Products. PMID 26204500 DOI: 10.1021/acs.jnatprod.5b00293  1
2015 Luo D, Luesch H. A dive into membrane dynamics with sponge peptides. Chemistry & Biology. 22: 565-7. PMID 26000744 DOI: 10.1016/j.chembiol.2015.05.003  1
2015 Peddibhotla S, Fontaine P, Leung CK, Maloney P, Hershberger PM, Wang Y, Bousquet MS, Luesch H, Mangravita-Novo A, Pinkerton AB, Smith LH, Malany S, Choe K. Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. Acs Chemical Biology. 10: 1871-9. PMID 25946346 DOI: 10.1021/acschembio.5b00304  1
2015 Salvador-Reyes LA, Engene N, Paul VJ, Luesch H. Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation. Journal of Natural Products. 78: 486-92. PMID 25635943 DOI: 10.1021/np500931q  1
2015 Salvador-Reyes LA, Luesch H. Biological targets and mechanisms of action of natural products from marine cyanobacteria. Natural Product Reports. 32: 478-503. PMID 25571978 DOI: 10.1039/c4np00104d  0.64
2014 Salvador LA, Park H, Al-Awadhi FH, Liu Y, Kim B, Zeller SL, Chen QY, Hong J, Luesch H. Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties. Acs Medicinal Chemistry Letters. 5: 905-10. PMID 25147612 DOI: 10.1021/ml500170r  1
2014 Kim B, Park H, Salvador LA, Serrano PE, Kwan JC, Zeller SL, Chen QY, Ryu S, Liu Y, Byeon S, Luesch H, Hong J. Evaluation of class I HDAC isoform selectivity of largazole analogues. Bioorganic & Medicinal Chemistry Letters. 24: 3728-31. PMID 25070421 DOI: 10.1016/j.bmcl.2014.07.006  1
2014 Chen QY, Liu Y, Cai W, Luesch H. Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity. Journal of Medicinal Chemistry. 57: 3011-29. PMID 24660812 DOI: 10.1021/jm4019965  1
2014 Yu M, Salvador LA, Sy SK, Tang Y, Singh RS, Chen QY, Liu Y, Hong J, Derendorf H, Luesch H. Largazole pharmacokinetics in rats by LC-MS/MS. Marine Drugs. 12: 1623-40. PMID 24658499 DOI: 10.3390/md12031623  1
2014 Kwan JC, Liu Y, Ratnayake R, Hatano R, Kuribara A, Morimoto C, Ohnuma K, Paul VJ, Ye T, Luesch H. Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation. Chembiochem : a European Journal of Chemical Biology. 15: 799-804. PMID 24591193 DOI: 10.1002/cbic.201300762  1
2013 Ratnayake R, Liu Y, Paul VJ, Luesch H. Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system. Cancer Prevention Research (Philadelphia, Pa.). 6: 989-99. PMID 24005795 DOI: 10.1158/1940-6207.CAPR-13-0014  1
2013 Montaser R, Paul VJ, Luesch H. Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids. Organic Letters. 15: 4050-3. PMID 23915229 DOI: 10.1021/ol401396u  1
2013 Wang R, Mason DE, Choe KP, Lewin AS, Peters EC, Luesch H. In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway Acs Chemical Biology. 8: 1764-1774. PMID 23773140 DOI: 10.1021/cb4000103  1
2013 Liu H, Liu Y, Wang Z, Xing X, Maguire AR, Luesch H, Zhang H, Xu Z, Ye T. Total synthesis and biological evaluation of grassypeptolide A. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 6774-84. PMID 23536467 DOI: 10.1002/chem.201203667  1
2013 Salvador LA, Taori K, Biggs JS, Jakoncic J, Ostrov DA, Paul VJ, Luesch H. Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. Journal of Medicinal Chemistry. 56: 1276-90. PMID 23350733 DOI: 10.1021/jm3017305  1
2013 Wang R, Paul VJ, Luesch H. Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway. Free Radical Biology & Medicine. 57: 141-53. PMID 23291594 DOI: 10.1016/j.freeradbiomed.2012.12.019  1
2012 Liu Y, Zhang W, Li L, Salvador LA, Chen T, Chen W, Felsenstein KM, Ladd TB, Price AR, Golde TE, He J, Xu Y, Li Y, Luesch H. Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. Journal of Medicinal Chemistry. 55: 10749-65. PMID 23181502 DOI: 10.1021/jm301630s  1
2012 Montaser R, Paul VJ, Luesch H. Marine cyanobacterial fatty acid amides acting on cannabinoid receptors. Chembiochem : a European Journal of Chemical Biology. 13: 2676-81. PMID 23143757 DOI: 10.1002/cbic.201200502  1
2012 Yang S, Zhang W, Ding N, Lo J, Liu Y, Clare-Salzler MJ, Luesch H, Li Y. Total synthesis of grassystatin A, a probe for cathepsin E function. Bioorganic & Medicinal Chemistry. 20: 4774-80. PMID 22748705 DOI: 10.1016/j.bmc.2012.05.077  1
2012 Salvador LA, Luesch H. Discovery and mechanism of natural products as modulators of histone acetylation. Current Drug Targets. 13: 1029-47. PMID 22594471  1
2012 Hong J, Luesch H. Largazole: from discovery to broad-spectrum therapy. Natural Product Reports. 29: 449-56. PMID 22334030 DOI: 10.1039/c2np00066k  1
2011 Santos N, Wenger JB, Havre P, Liu Y, Dagan R, Imanirad I, Ivey AM, Zlotecki RA, Algood CB, Gilbert SM, Allegra CJ, Okunieff P, Vieweg J, Dang NH, Luesch H, et al. Combination therapy for renal cell cancer: What are possible options? Oncology. 81: 220-229. PMID 22085914 DOI: 10.1159/000333470  1
2011 Chen QY, Liu Y, Luesch H. Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity. Acs Medicinal Chemistry Letters. 2: 861-865. PMID 22081789 DOI: 10.1021/ml200176m  1
2011 Wenger JB, Santos N, Liu Y, Dallas J, Subbiah S, Hochwald S, Huang EH, Dang DT, Allegra CJ, Luesch H, Dang LH. Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma? Oncology Reviews. 5: 177-184. PMID 21949574 DOI: 10.4081/oncol.2011.177  1
2011 Montaser R, Luesch H. Marine natural products: a new wave of drugs? Future Medicinal Chemistry. 3: 1475-89. PMID 21882941 DOI: 10.4155/fmc.11.118  1
2011 Montaser R, Paul VJ, Luesch H. Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Phytochemistry. 72: 2068-74. PMID 21843895 DOI: 10.1016/j.phytochem.2011.07.014  1
2011 Meickle T, Gunasekera SP, Liu Y, Luesch H, Paul VJ. Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp. Bioorganic & Medicinal Chemistry. 19: 6576-80. PMID 21705224 DOI: 10.1016/j.bmc.2011.05.051  1
2011 Lee SU, Kwak HB, Pi SH, You HK, Byeon SR, Ying Y, Luesch H, Hong J, Kim SH. In Vitro and In Vivo Osteogenic Activity of Largazole. Acs Medicinal Chemistry Letters. 2: 248-251. PMID 21666868 DOI: 10.1021/ml1002794  1
2011 Salvador LA, Biggs JS, Paul VJ, Luesch H. Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. Journal of Natural Products. 74: 917-27. PMID 21446699 DOI: 10.1021/np200076t  1
2011 Gunasekera SP, Owle CS, Montaser R, Luesch H, Paul VJ. Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam. Journal of Natural Products. 74: 871-6. PMID 21341718 DOI: 10.1021/np1008015  1
2011 Kwan JC, Meickle T, Ladwa D, Teplitski M, Paul V, Luesch H. Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa Molecular Biosystems. 7: 1205-1216. PMID 21258753 DOI: 10.1039/c0mb00180e  1
2011 Montaser R, Abboud KA, Paul VJ, Luesch H. Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam. Journal of Natural Products. 74: 109-12. PMID 21138309 DOI: 10.1021/np1006839  1
2011 Akindele AJ, Eksioglu EA, Kwan JC, Adeyemi OO, Liu C, Luesch H, James MO. Biological effects of Byrsocarpus coccineus in vitro. Pharmaceutical Biology. 49: 152-60. PMID 21110733 DOI: 10.3109/13880209.2010.504967  0.96
2011 Wenger JB, Chun SY, Dang DT, Luesch H, Dang LH. Combination therapy targeting cancer metabolism Medical Hypotheses. 76: 169-172. PMID 20947261 DOI: 10.1016/j.mehy.2010.09.008  1
2010 Kwan JC, Ratnayake R, Abboud KA, Paul VJ, Luesch H. Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides. The Journal of Organic Chemistry. 75: 8012-23. PMID 21047144 DOI: 10.1021/jo1013564  1
2010 Kwan JC, Luesch H. Weapons in disguise-Activating mechanisms and protecting group chemistry in nature Chemistry - a European Journal. 16: 13020-13029. PMID 20931575 DOI: 10.1002/chem.201001562  1
2010 Salvador LA, Paul VJ, Luesch H. Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. Journal of Natural Products. 73: 1606-9. PMID 20806908 DOI: 10.1021/np100467d  1
2010 Liu Y, Salvador LA, Byeon S, Ying Y, Kwan JC, Law BK, Hong J, Luesch H. Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 335: 351-61. PMID 20739454 DOI: 10.1124/jpet.110.172387  1
2010 Matthew S, Salvador LA, Schupp PJ, Paul VJ, Luesch H. Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. Journal of Natural Products. 73: 1544-52. PMID 20704304 DOI: 10.1021/np1004032  1
2010 Matthew S, Ratnayake R, Becerro MA, Ritson-Williams R, Paul VJ, Luesch H. Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. Marine Drugs. 8: 1803-16. PMID 20631871 DOI: 10.3390/md8061803  1
2010 Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, et al. Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nature Cell Biology. 12: 758-67. PMID 20622870 DOI: 10.1038/ncb2080  1
2010 Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS. A small-molecule inducer of the antioxidant response element. Chemistry & Biology. 17: 537-47. PMID 20534351 DOI: 10.1016/j.chembiol.2010.03.013  1
2010 Kwan JC, Teplitski M, Gunasekera SP, Paul VJ, Luesch H. Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 73: 463-6. PMID 20166701 DOI: 10.1021/np900614n  1
2010 Gunasekera SP, Miller MW, Kwan JC, Luesch H, Paul VJ. Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis. Journal of Natural Products. 73: 459-62. PMID 20020755 DOI: 10.1021/np900603f  1
2009 Kwan JC, Taori K, Paul VJ, Luesch H. Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena. Marine Drugs. 7: 528-38. PMID 20098596 DOI: 10.3390/md7040528  1
2009 Matthew S, Paul VJ, Luesch H. Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides. Phytochemistry. 70: 2058-63. PMID 19815244 DOI: 10.1016/j.phytochem.2009.09.010  1
2009 Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H. Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. Journal of Medicinal Chemistry. 52: 5732-47. PMID 19715320 DOI: 10.1021/jm9009394  1
2009 Taori K, Liu Y, Paul VJ, Luesch H. Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole. Chembiochem : a European Journal of Chemical Biology. 10: 1634-9. PMID 19514039 DOI: 10.1002/cbic.200900192  1
2009 Schriner SE, Avanesian A, Liu Y, Luesch H, Jafari M. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radical Biology & Medicine. 47: 577-84. PMID 19486939 DOI: 10.1016/j.freeradbiomed.2009.05.025  1
2009 Wang R, Kern JT, Goodfriend TL, Ball DL, Luesch H. Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 81: 53-9. PMID 19481916 DOI: 10.1016/j.plefa.2009.04.008  1
2009 Meickle T, Matthew S, Ross C, Luesch H, Paul V. Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa. Planta Medica. 75: 1427-30. PMID 19431099 DOI: 10.1055/s-0029-1185675  1
2009 Liu Y, Law BK, Luesch H. Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation. Molecular Pharmacology. 76: 91-104. PMID 19403701 DOI: 10.1124/mol.109.056085  1
2009 Wilson KR, Proneth B, Luesch H, Litherland SA, Haskell-Luevano C. Construction and characterization of melanocortin-2 and -4 receptor chimeras. Advances in Experimental Medicine and Biology. 611: 301-2. PMID 19400202 DOI: 10.1007/978-0-387-73657-0_135  1
2009 Sharp K, Arthur KE, Gu L, Ross C, Harrison G, Gunasekera SP, Meickle T, Matthew S, Luesch H, Thacker RW, Sherman DH, Paul VJ. Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Applied and Environmental Microbiology. 75: 2879-88. PMID 19270119 DOI: 10.1128/AEM.02656-08  1
2009 Matthew S, Paul VJ, Luesch H. Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Planta Medica. 75: 528-33. PMID 19214948 DOI: 10.1055/s-0029-1185332  1
2008 Luesch H, Liu Y. Genome-wide overexpression screen for activators of antioxidant gene transcription. Methods in Molecular Biology (Clifton, N.J.). 477: 343-54. PMID 19082959 DOI: 10.1007/978-1-60327-517-0_26  1
2008 Ying Y, Liu Y, Byeon SR, Kim H, Luesch H, Hong J. Synthesis and activity of largazole analogues with linker and macrocycle modification. Organic Letters. 10: 4021-4. PMID 18707106 DOI: 10.1021/ol801532s  1
2008 Taori K, Paul VJ, Luesch H. Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp. Journal of Natural Products. 71: 1625-9. PMID 18693761 DOI: 10.1021/np8002172  1
2008 Ying Y, Taori K, Kim H, Hong J, Luesch H. Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. Journal of the American Chemical Society. 130: 8455-9. PMID 18507379 DOI: 10.1021/ja8013727  1
2008 Matthew S, Schupp PJ, Luesch H. Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. Journal of Natural Products. 71: 1113-6. PMID 18461997 DOI: 10.1021/np700717s  0.92
2008 Gunasekera SP, Ross C, Paul VJ, Matthew S, Luesch H. Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa. Journal of Natural Products. 71: 887-90. PMID 18393465 DOI: 10.1021/np0706769  1
2008 Kwan JC, Rocca JR, Abboud KA, Paul VJ, Luesch H. Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin. Organic Letters. 10: 789-92. PMID 18220404 DOI: 10.1021/ol702946d  1
2008 Taori K, Paul VJ, Luesch H. Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. Journal of the American Chemical Society. 130: 1806-7. PMID 18205365 DOI: 10.1021/ja7110064  1
2007 Taori K, Matthew S, Rocca JR, Paul VJ, Luesch H. Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp. Journal of Natural Products. 70: 1593-600. PMID 17910513 DOI: 10.1021/np0702436  1
2007 Liu Y, Kern JT, Walker JR, Johnson JA, Schultz PG, Luesch H. A genomic screen for activators of the antioxidant response element. Proceedings of the National Academy of Sciences of the United States of America. 104: 5205-10. PMID 17360324 DOI: 10.1073/pnas.0700898104  1
2007 Matthew S, Ross C, Rocca JR, Paul VJ, Luesch H. Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Journal of Natural Products. 70: 124-7. PMID 17253864 DOI: 10.1021/np060471k  1
2006 Luesch H, Chanda SK, Raya RM, DeJesus PD, Orth AP, Walker JR, Izpisúa Belmonte JC, Schultz PG. A functional genomics approach to the mode of action of apratoxin A. Nature Chemical Biology. 2: 158-67. PMID 16474387 DOI: 10.1038/nchembio769  1
2005 Luesch H, Wu TY, Ren P, Gray NS, Schultz PG, Supek F. A genome-wide overexpression screen in yeast for small-molecule target identification. Chemistry & Biology. 12: 55-63. PMID 15664515 DOI: 10.1016/j.chembiol.2004.10.015  0.68
2003 Williams PG, Luesch H, Yoshida WY, Moore RE, Paul VJ. Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D. Journal of Natural Products. 66: 595-8. PMID 12762789 DOI: 10.1021/np030011g  1
2003 Mooberry SL, Leal RM, Tinley TL, Luesch H, Moore RE, Corbett TH. The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog. International Journal of Cancer. Journal International Du Cancer. 104: 512-21. PMID 12584751 DOI: 10.1002/ijc.10982  1
2003 Luesch H, Hoffmann D, Hevel JM, Becker JE, Golakoti T, Moore RE. Biosynthesis of 4-methylproline in cyanobacteria: cloning of nosE and nosF genes and biochemical characterization of the encoded dehydrogenase and reductase activities. The Journal of Organic Chemistry. 68: 83-91. PMID 12515465 DOI: 10.1021/jo026479q  1
2002 Luesch H, Yoshida WY, Harrigan GG, Doom JP, Moore RE, Paul VJ. Lyngbyaloside B, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp. Journal of Natural Products. 65: 1945-8. PMID 12502348 DOI: 10.1021/np0202879  1
2002 Luesch H, Williams PG, Yoshida WY, Moore RE, Paul VJ. Ulongamides A-F, new beta-amino acid-containing cyclodepsipeptides from Palauan collections of the marine cyanobacterium Lyngbya sp. Journal of Natural Products. 65: 996-1000. PMID 12141859 DOI: 10.1021/np0200461  1
2002 Luesch H, Yoshida WY, Moore RE, Paul VJ. New apratoxins of marine cyanobacterial origin from Guam and Palau. Bioorganic & Medicinal Chemistry. 10: 1973-8. PMID 11937357 DOI: 10.1016/S0968-0896(02)00014-7  1
2002 Luesch H, Yoshida WY, Moore RE, Paul VJ, Mooberry SL, Corbett TH. Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. Journal of Natural Products. 65: 16-20. PMID 11809057 DOI: 10.1021/np010317s  1
2001 Luesch H, Moore RE, Paul VJ, Mooberry SL, Corbett TH. Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1. Journal of Natural Products. 64: 907-10. PMID 11473421 DOI: 10.1021/np010049y  1
2001 Luesch H, Yoshida WY, Moore RE, Paul VJ, Corbett TH. Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula. Journal of the American Chemical Society. 123: 5418-23. PMID 11389621 DOI: 10.1021/ja010453j  1
2001 Luesch H, Pangilinan R, Yoshida WY, Moore RE, Paul VJ. Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 64: 304-7. PMID 11277744 DOI: 10.1021/np000456u  1
2000 Luesch H, Yoshida WY, Moore RE, Paul VJ. Isolation and structure of the cytotoxin lyngbyabellin B and absolute configuration of lyngbyapeptin A from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 63: 1437-9. PMID 11076573 DOI: 10.1021/np000104n  1
2000 Luesch H, Yoshida WY, Moore RE, Paul VJ. Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 63: 1106-12. PMID 10978206 DOI: 10.1021/np000078t  1
2000 Luesch H, Yoshida WY, Moore RE, Paul VJ, Mooberry SL. Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium lyngbya majuscula. Journal of Natural Products. 63: 611-5. PMID 10843570 DOI: 10.1021/np990543q  1
1999 Luesch H, Yoshida WY, Moore RE, Paul VJ. Lyngbyastatin 2 and norlyngbyastatin 2, analogues of dolastatin G and nordolastatin G from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products. 62: 1702-6. PMID 10654420 DOI: 10.1021/np990310z  1
1999 Harrigan GG, Luesch H, Yoshida WY, Moore RE, Nagle DG, Paul VJ. Symplostatin 2: a dolastatin 13 analogue from the marine cyanobacterium Symploca hydnoides. Journal of Natural Products. 62: 655-8. PMID 10217737 DOI: 10.1021/np980553b  1
1999 Harrigan GG, Luesch H, Yoshida WY, Moore RE, Nagle DG, Biggs J, Park PU, Paul VJ. Tumonoic acids, novel metabolites from a cyanobacterial assemblage of Lyngbya majuscula and Schizothrix calcicola. Journal of Natural Products. 62: 464-7. PMID 10096859 DOI: 10.1021/np980460u  1
1998 Harrigan GG, Luesch H, Yoshida WY, Moore RE, Nagle DG, Paul VJ, Mooberry SL, Corbett TH, Valeriote FA. Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides. Journal of Natural Products. 61: 1075-7. PMID 9748368 DOI: 10.1021/np980321c  1
Show low-probability matches.