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Rachel F. Tyndale, Ph.D. - Publications

Affiliations: 
Departments of Pharmacology and Toxicology and Psychiatry CAMH/University of Toronto 
Area:
Addiction, Drug Metabolism
Website:
http://www.pharmtox.utoronto.ca/faculty/directory/tyndale.htm
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Year Citation  Score
2023 Roeder NM, Mihalkovic A, Richardson BJ, Penman SL, Novalen M, Hammond N, Eiden R, Khokhar JY, Tyndale RF, Thanos PK. Behavioral and pharmacokinetic assessment of nicotine e-cigarette inhalation in female rats. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 38092656 DOI: 10.1093/ntr/ntad240  0.682
2023 Frie JA, McCunn P, Eed A, Hassan A, Luciani KR, Chen C, Tyndale RF, Khokhar JY. Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 38057369 DOI: 10.1038/s41386-023-01773-3  0.672
2023 Cooper RK, Mahoney MC, Tiffany ST, Colder CR, Tyndale RF, Hawk LW. Relationships Between the Nicotine Metabolite Ratio (NMR) and Laboratory Assessments of Smoking Reinforcement and Craving Among Adults in a Smoking Cessation Trial. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 37996099 DOI: 10.1093/ntr/ntad232  0.345
2023 Medaglio D, Bilker WB, Han X, Merlin JS, Plankey M, Martin J, Crane HM, Hojat LS, Bamford L, Schnoll R, Tyndale RF, Ashare RL, Gross R. Nicotine Metabolite Ratio Decreases after Switching off Efavirenz-based Therapy in People with HIV who Smoke. Clinical Pharmacology and Therapeutics. PMID 37787039 DOI: 10.1002/cpt.3068  0.331
2023 Lee SS, Chang Y, Rigotti NA, Singer DE, Levy DE, Tyndale RF, Davis EM, Freiberg MS, King S, Wells QS, Tindle HA. Can treatment support mitigate nicotine metabolism-based disparities in smoking abstinence? Secondary analysis of the Helping HAND 4 trial. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 37209421 DOI: 10.1093/ntr/ntad079  0.355
2023 Ghahremani DG, Pochon JF, Diaz MP, Tyndale RF, Dean AC, London ED. Nicotine dependence and insula subregions: functional connectivity and cue-induced activation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 36869233 DOI: 10.1038/s41386-023-01528-0  0.322
2023 Chenoweth MJ, Lerman C, Knight J, Tyndale RF. Influence of CYP2A6 genetic variation, nicotine dependence severity, and treatment on smoking cessation success. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 36789481 DOI: 10.1093/ntr/ntac268  0.38
2021 Schaefer KR, Avey JP, Todd MR, Beans JA, Dillard DA, Shireman LM, Thornton TA, Tyndale RF, Thummel KE, Robinson RF, Claw KG. Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke. Clinical and Translational Science. PMID 34520119 DOI: 10.1111/cts.13115  0.357
2021 El-Boraie A, Tyndale RF. The Role of Pharmacogenetics in Smoking. Clinical Pharmacology and Therapeutics. PMID 34165800 DOI: 10.1002/cpt.2345  0.344
2021 Giratallah HK, Chenoweth MJ, Addo N, Ahluwalia JS, Cox LS, Lerman C, George TP, Benowitz NL, Tyndale RF. Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies. Drug and Alcohol Dependence. 223: 108708. PMID 33873029 DOI: 10.1016/j.drugalcdep.2021.108708  0.332
2021 Butler K, Chenoweth MJ, El-Boraie A, Giratallah H, Kowalczyk WJ, Heishman SJ, Tyndale RF, Le Foll B. Impact Of Cyp2a6 Activity On Nicotine Reinforcement And Cue-Reactivity In Daily Smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 33823003 DOI: 10.1093/ntr/ntab064  0.376
2021 Schnoll R, Paul Wileyto E, Bauer AM, Fox E, Leone F, Lerman C, Tyndale RF, George TP, Hawk L, Cinciripini P, Quinn M, Purnell J, Hatzell J, Hitsman B. Comparing the Rate of Nicotine Metabolism Among Smokers With Current or Past Major Depressive Disorder. The American Journal On Addictions. PMID 33772971 DOI: 10.1111/ajad.13155  0.317
2021 Liakoni E, Tyndale RF, Jacob P, Dempsey DA, Addo N, Benowitz NL. Effect of race and glucuronidation rates on the relationship between nicotine metabolite ratio and nicotine clearance. Pharmacogenetics and Genomics. PMID 33675323 DOI: 10.1097/FPC.0000000000000427  0.344
2021 Cunningham JA, Kushnir V, Selby P, Zawertailo L, Tyndale RF, Leatherdale ST, Godinho A, Schell C. Use of additional nicotine replacement therapy by participants in a five-year follow-up of a tobacco cessation trial. Addictive Behaviors. 117: 106875. PMID 33639391 DOI: 10.1016/j.addbeh.2021.106875  0.303
2020 Gao Y, Miksys S, Palmour RM, Tyndale RF. The influence of tobacco smoke/nicotine on CYP2A expression in Human and African Green Monkey Lungs. Molecular Pharmacology. PMID 33055223 DOI: 10.1124/molpharm.120.000100  0.339
2020 McMillan DM, El-Sherbeni AA, Richards J, Tyndale RF. Centrally administered CYP2D inhibitors increase oral tramadol analgesia in rats. Brain Research Bulletin. PMID 32926950 DOI: 10.1016/J.Brainresbull.2020.09.001  0.356
2020 Frie JA, Underhill J, Zhao B, de Guglielmo G, Tyndale RF, Khokhar JY. OpenVape: an Open-Source E-Cigarette Vapour Exposure Device for Rodents. Eneuro. PMID 32859723 DOI: 10.1523/ENEURO.0279-20.2020  0.667
2020 Henderson JA, Buchwald DS, Howard BV, Henderson PN, Li Y, Tyndale RF, Amos CI, Gorlova OY. Genetics of smoking behavior in American Indians. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 32855268 DOI: 10.1158/1055-9965.Epi-20-0026  0.356
2020 Bray MJ, Chen LS, Fox L, Hancock DB, Culverhouse RC, Hartz SM, Johnson EO, Liu M, McKay JD, Saccone NL, Hokanson JE, Vrieze SI, Tyndale RF, Baker TB, Bierut LJ. Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme. Genetic Epidemiology. PMID 32803792 DOI: 10.1002/Gepi.22331  0.421
2020 Stocco MR, Tolledo C, Wadji FB, Gonzalez FJ, Miksys S, Tyndale RF. Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice. Molecular Neurobiology. PMID 32761352 DOI: 10.1007/S12035-020-02050-W  0.311
2020 Higgins ST, DeSarno M, Davis DR, Nighbor T, Streck JM, Adise S, Harfmann R, Nesheim-Case R, Markesich C, Reed D, Tyndale RF, Gaalema DE, Heil SH, Sigmon SC, Tidey JW, et al. Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations. Preventive Medicine. 106189. PMID 32628945 DOI: 10.1016/J.Ypmed.2020.106189  0.432
2020 Zawertailo L, Hendershot CS, Tyndale RF, Le Foll B, Samokhvalov AV, Thorpe KE, Pipe A, Reid RD, Selby P. Personalized dosing of nicotine replacement therapy versus standard dosing for the treatment of individuals with tobacco dependence: study protocol for a randomized placebo-controlled trial. Trials. 21: 592. PMID 32600406 DOI: 10.1186/S13063-020-04532-7  0.432
2020 Schlagintweit HE, Tyndale RF, Hendershot CS. Acute effects of a very low nicotine content cigarette on laboratory smoking lapse: Impacts of nicotine metabolism and nicotine dependence. Addiction Biology. e12930. PMID 32573054 DOI: 10.1111/Adb.12930  0.473
2020 Schnoll R, Paul Wileyto E, Gross R, Hitsman B, Hawk LW, Cinciripini P, George TP, Benowitz NL, Fen Lubitz S, Ashare R, Tyndale RF, Lerman C. Evaluation of nicotine patch adherence measurement using self-report and saliva cotinine among abstainers in a smoking cessation trial. Drug and Alcohol Dependence. 210: 107967. PMID 32224420 DOI: 10.1016/J.Drugalcdep.2020.107967  0.415
2020 Tolledo C, Stocco MR, Miksys S, Gonzalez FJ, Tyndale RF. Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice. Molecular Neurobiology. PMID 32189192 DOI: 10.1007/S12035-020-01896-4  0.329
2020 Buchwald J, Chenoweth MJ, Palviainen T, Zhu G, Benner C, Gordon S, Korhonen T, Ripatti S, Madden PAF, Lehtimäki T, Raitakari OT, Salomaa V, Rose RJ, George TP, Lerman C, ... ... Tyndale RF, et al. Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent. Molecular Psychiatry. PMID 32157176 DOI: 10.1038/S41380-020-0702-Z  0.333
2020 Cunningham JA, Kushnir V, Selby P, Zawertailo L, Tyndale RF, Leatherdale ST, Schell C. Five-Year Follow-up of a Randomized Clinical Trial Testing Mailed Nicotine Patches to Promote Tobacco Cessation. Jama Internal Medicine. PMID 32150239 DOI: 10.1001/Jamainternmed.2020.0001  0.369
2020 Best LM, Williams B, Le Foll B, Mansouri E, Bazinet RP, Lin L, De Luca V, Lagzdins D, Rusjan P, Tyndale RF, Wilson AA, Hendershot CS, Heilig M, Houle S, Tong J, et al. Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31910433 DOI: 10.1038/S41386-020-0606-2  0.332
2019 Mansouri E, Nobrega JN, Hill MN, Tyndale RF, Lee FS, Hendershot CS, Best LM, Di Ciano P, Balsevich G, Sloan ME, Kish SJ, Tong J, Le Foll B, Boileau I. D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31775159 DOI: 10.1038/S41386-019-0580-8  0.304
2019 Liakoni E, Nardone N, St Helen G, Dempsey DA, Tyndale RF, Benowitz NL. Effects of Nicotine Metabolic Rate on Cigarette Reinforcement. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31725872 DOI: 10.1093/Ntr/Ntz210  0.474
2019 Akinola LS, Mckiver B, Toma W, Zhu AZX, Tyndale RF, Kumar V, Damaj MI. C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration. Brain Sciences. 9. PMID 31546627 DOI: 10.3390/Brainsci9100244  0.349
2019 Liakoni E, St Helen G, Dempsey DA, Jacob P, Tyndale RF, Benowitz NL. Relationship between skin melanin index and nicotine pharmacokinetics in African American smokers. Drug and Alcohol Dependence. 204: 107474. PMID 31521954 DOI: 10.1016/J.Drugalcdep.2019.04.039  0.457
2019 Peng AR, Swardfager W, Benowitz NL, Ahluwalia JS, Lerman C, Nollen NL, Tyndale RF. Impact of Early Nausea on Varenicline Adherence and Smoking Cessation. Addiction (Abingdon, England). PMID 31502736 DOI: 10.1111/Add.14810  0.344
2019 Claw KG, Beans JA, Lee SB, Avey JP, Stapleton PA, Scherer SE, El-Boraie A, Tyndale RF, Nickerson DA, Dillard DA, Thummel KE, Robinson RF. Pharmacogenomics of nicotine metabolism: novel CYP2A6 and CYP2B6 genetic variation patterns in Alaska Native and American Indian populations. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31241144 DOI: 10.1093/Ntr/Ntz105  0.464
2019 St Helen G, Benowitz NL, Ahluwalia JS, Tyndale RF, Addo N, Gregorich SE, Pérez-Stable EJ, Cox LS. Black Light Smokers: How Nicotine Intake and Carcinogen Exposure Differ Across Various Biobehavioral Factors. Journal of the National Medical Association. PMID 31084916 DOI: 10.1016/J.Jnma.2019.04.004  0.312
2019 El-Boraie A, Taghavi T, Chenoweth MJ, Fukunaga K, Mushiroda T, Kubo M, Lerman C, Nollen NL, Benowitz NL, Tyndale RF. Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity. Addiction Biology. PMID 30815984 DOI: 10.1111/Adb.12741  0.46
2019 Bagdas D, Cam B, Gul Z, Scott MM, Tyndale RF, Buyukuysal RL, Damaj MI, Gurun MS. Impact of menthol on oral nicotine consumption in female and male Sprague Dawley rats. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 30753589 DOI: 10.1093/Ntr/Ntz019  0.301
2019 Arguelles N, Wadji FB, Novalen M, Miksys S, Tyndale R. Sex differences in brain oxycodone metabolism and analgesia Drug Metabolism and Pharmacokinetics. 34: S29. DOI: 10.1016/J.Dmpk.2018.09.114  0.324
2019 Peng AR, Schnoll R, Lerman C, Tyndale RF. Different measures of varenicline adherence, nicotine metabolite ratio and smoking abstinence Drug Metabolism and Pharmacokinetics. 34: S16-S17. DOI: 10.1016/J.Dmpk.2018.09.077  0.451
2018 Mercincavage M, Lochbuehler K, Wileyto EP, Benowitz NL, Tyndale RF, Lerman C, Strasser AA. Association of Reduced Nicotine Content Cigarettes With Smoking Behaviors and Biomarkers of Exposure Among Slow and Fast Nicotine Metabolizers: A Nonrandomized Clinical Trial. Jama Network Open. 1. PMID 30627706 DOI: 10.1001/jamanetworkopen.2018.1346  0.377
2018 Dermody SS, Hendershot CS, Andrade AK, Novalen M, Tyndale RF. Changes in Nicotine Metabolite Ratio among Daily Smokers receiving Treatment for Alcohol Use Disorder. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 30561731 DOI: 10.1093/Ntr/Nty265  0.406
2018 Schnoll RA, Thompson M, Serrano K, Leone F, Metzger D, Frank I, Gross R, Mounzer K, Tyndale RF, Weisbrot J, Meline M, Collman RG, Ashare RL. Rate of Nicotine Metabolism and Tobacco Use among Persons with HIV: Implications for Treatment and Research. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 30399039 DOI: 10.1097/Qai.0000000000001895  0.457
2018 Faulkner P, Ghahremani DG, Tyndale RF, Paterson NE, Cox C, Ginder N, Hellemann G, London ED. Neural basis of smoking-induced relief of craving and negative affect: Contribution of nicotine. Addiction Biology. PMID 30307083 DOI: 10.1111/Adb.12679  0.335
2018 Shahab L, Bauld L, McNeill A, Tyndale RF. Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real-world settings? A prospective study. Addiction (Abingdon, England). PMID 30276911 DOI: 10.1111/add.14450  0.329
2018 Liakoni E, Edwards KC, St Helen G, Nardone N, Dempsey DA, Tyndale RF, Benowitz NL. Effects of Nicotine Metabolic Rate on withdrawal symptoms and response to cigarette smoking following abstinence. Clinical Pharmacology and Therapeutics. PMID 30242831 DOI: 10.1002/Cpt.1238  0.489
2018 Arger CA, Taghavi T, Heil SH, Skelly J, Tyndale RF, Higgins ST. Pregnancy-Induced Increases in the Nicotine Metabolite Ratio: Examining Changes During Antepartum and Postpartum. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 30165458 DOI: 10.1093/Ntr/Nty172  0.419
2018 Crawford G, Jao N, Peng AR, Leone F, Kalhan R, Tyndale RF, Weisbrot J, Hitsman B, Schnoll R. The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence. Addictive Behaviors Reports. 8: 46-50. PMID 29998189 DOI: 10.1016/J.Abrep.2018.06.006  0.309
2018 Faulkner P, Ghahremani DG, Tyndale RF, Hellemann G, London ED. Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers. The International Journal of Neuropsychopharmacology. PMID 29924326 DOI: 10.1093/Ijnp/Pyy054  0.407
2018 Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF. Cigarette Consumption and Biomarkers of Nicotine Exposure during Pregnancy and Postpartum. Addiction (Abingdon, England). PMID 29920836 DOI: 10.1111/Add.14367  0.442
2018 Taghavi T, Novalen M, Lerman C, George TP, Tyndale RF. A comparison of direct and indirect analytical approaches to measuring total nicotine equivalents in urine. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 29853480 DOI: 10.1158/1055-9965.Epi-18-0018  0.41
2018 Di Ciano P, Tyndale RF, Mansouri E, Hendershot CS, Wilson AA, Lagzdins D, Houle S, Boileau I, Le Foll B. Influence of Nicotine Metabolism Ratio on [11C]-(+)-PHNO PET binding in Tobacco Smokers. The International Journal of Neuropsychopharmacology. PMID 29346545 DOI: 10.1093/Ijnp/Pyx119  0.494
2018 Tanner JA, Zhu AZ, Claw KG, Prasad B, Korchina V, Hu J, Doddapaneni H, Muzny DM, Schuetz EG, Lerman C, Thummel KE, Scherer SE, Tyndale RF. Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenetics and Genomics. 28: 7-16. PMID 29232328 DOI: 10.1097/Fpc.0000000000000317  0.388
2018 Wang J, Conti D, Epeldegui M, Ollikainen M, Hwang AE, Hamilton AS, Magpantay L, Tyndale R, Mack TM, Martinez-Maza O, Kaprio J, Cozen W. Abstract 3228: Tobacco smoking and circulating immune-related biomarkers in monozygotic twins Cancer Research. 78: 3228-3228. DOI: 10.1158/1538-7445.Am2018-3228  0.368
2018 Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF. Changes in nicotine metabolic pathways across pregnancy: A longitudinal study Drug Metabolism and Pharmacokinetics. 33: S38-S39. DOI: 10.1016/J.Dmpk.2017.11.138  0.382
2017 Tanner JA, Tyndale RF. Variation in CYP2A6 Activity and Personalized Medicine. Journal of Personalized Medicine. 7. PMID 29194389 DOI: 10.3390/jpm7040018  0.339
2017 McMillan DM, Tyndale RF. CYP-mediated drug metabolism in the brain impacts drug response. Pharmacology & Therapeutics. PMID 29024742 DOI: 10.1016/J.Pharmthera.2017.10.008  0.341
2017 Faulkner P, Petersen N, Ghahremani DG, Cox CM, Tyndale RF, Hellemann GS, London ED. Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers. Psychopharmacology. PMID 29022071 DOI: 10.1007/S00213-017-4755-X  0.451
2017 Chenoweth MJ, Ware JJ, Zhu AZX, Cole CB, Cox LS, Nollen N, Ahluwalia JS, Benowitz NL, Schnoll RA, Hawk LW, Cinciripini PM, George TP, Lerman C, Knight J, Tyndale RF, et al. Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences. Addiction (Abingdon, England). PMID 28921760 DOI: 10.1111/Add.14032  0.37
2017 Kushnir V, Selby P, Zawertailo L, Tyndale RF, Leatherdale ST, Cunningham JA. Long-term effectiveness of mailed nicotine replacement therapy: study protocol of a randomized controlled trial 5-year follow-up. Bmc Public Health. 18: 28. PMID 28720080 DOI: 10.1186/S12889-017-4586-Z  0.372
2017 Ware JJ, Tanner JA, Taylor AE, Bin Z, Haycock P, Bowden J, Rogers PJ, Davey Smith G, Tyndale RF, Munafo MR. Does coffee consumption impact on heaviness of smoking? Addiction (Abingdon, England). PMID 28556459 DOI: 10.1111/Add.13888  0.353
2017 Ashare RL, Lerman C, Tyndale RF, Hawk LW, George TP, Cinciripini P, Schnoll RA. Sleep Disturbance During Smoking Cessation: Withdrawal or Side Effect of Treatment? Journal of Smoking Cessation. 12: 63-70. PMID 28553407 DOI: 10.1017/Jsc.2016.11  0.329
2017 Tanner JA, Henderson JA, Buchwald D, Howard BV, Nez Henderson P, Tyndale RF. Relationships between smoking behaviors and cotinine levels among two American Indian populations with distinct smoking patterns. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28549179 DOI: 10.1093/Ntr/Ntx114  0.367
2017 Cunningham JA, Kushnir V, Selby P, Tyndale RF, Zawertailo L, Leatherdale ST. Beyond quitting: Any additional impact of mailing free nicotine patches to current smokers? Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28521035 DOI: 10.1093/Ntr/Ntx106  0.426
2017 Jao NC, Veluz-Wilkins AK, Smith MJ, Carroll AJ, Blazekovic S, Leone FT, Tyndale RF, Schnoll RA, Hitsman B. Does menthol cigarette use moderate the effect of nicotine metabolism on short-term smoking cessation? Experimental and Clinical Psychopharmacology. 25: 216-222. PMID 28493744 DOI: 10.1037/Pha0000124  0.466
2017 Saccone NL, Baurley JW, Bergen AW, David SP, Elliott HR, Foreman MG, Kaprio J, Piasecki TM, Relton CL, Zawertailo L, Bierut LJ, Tyndale RF, Chen LS. The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28472521 DOI: 10.1093/Ntr/Ntx096  0.383
2017 Tanner JA, Henderson JA, Buchwald D, Howard BV, Nez Henderson P, Tyndale RF. Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer. Pharmacogenetics and Genomics. PMID 28181923 DOI: 10.1097/FPC.0000000000000271  0.315
2017 Taghavi T, St Helen G, Benowitz NL, Tyndale RF. Effect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans. Pharmacogenetics and Genomics. PMID 28178031 DOI: 10.1097/Fpc.0000000000000269  0.495
2017 Faulkner P, Ghahremani DG, Tyndale RF, Cox CM, Kazanjian AS, Paterson N, Lotfipour S, Hellemann GS, Petersen N, Vigil C, London ED. Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28117337 DOI: 10.1038/Npp.2017.18  0.382
2017 Gaalema D, Tidey JW, Tyndale R, Higgins S. Nicotine metabolite ratio and associations with smoking topography in a population with affective disorders Drug and Alcohol Dependence. 171: e67-e68. DOI: 10.1016/J.Drugalcdep.2016.08.195  0.424
2016 Moerke MJ, Zhu AZ, Tyndale RF, Javors MA, McMahon LR. The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-β-erythroidine. Neuropharmacology. PMID 27940077 DOI: 10.1016/J.Neuropharm.2016.12.003  0.338
2016 Li S, Yang Y, Hoffmann E, Tyndale RF, Stein EA. CYP2A6 Genetic Variation Alters Striatal-Cingulate Circuits, Network Hubs, and Executive Processing in Smokers. Biological Psychiatry. PMID 27865452 DOI: 10.1016/J.Biopsych.2016.09.013  0.426
2016 Chenoweth MJ, Tyndale RF. Pharmacogenetic Optimization of Smoking Cessation Treatment. Trends in Pharmacological Sciences. PMID 27712845 DOI: 10.1016/J.Tips.2016.09.006  0.449
2016 Kushnir V, Sproule BA, Zawertailo L, Selby P, Tyndale RF, Leatherdale ST, Cunningham JA. Impact of self-reported lifetime depression or anxiety on effectiveness of mass distribution of nicotine patches. Tobacco Control. PMID 27543563 DOI: 10.1136/Tobaccocontrol-2016-052994  0.373
2016 Garcia KL, Lê AD, Tyndale RF. Brain CYP2B induction can decrease nicotine levels in the brain. Addiction Biology. PMID 27230546 DOI: 10.1111/adb.12411  0.357
2016 Rabin RA, Ashare RL, Schnoll RA, Cinciripini PM, Hawk LW, Lerman C, Tyndale RF, George TP. Does cannabis use moderate smoking cessation outcomes in treatment-seeking tobacco smokers? Analysis from a large multi-center trial. The American Journal On Addictions / American Academy of Psychiatrists in Alcoholism and Addictions. PMID 27187893 DOI: 10.1111/Ajad.12382  0.395
2016 Ross KC, Gubner NR, Tyndale RF, Hawk LW, Lerman C, George TP, Cinciripini P, Schnoll RA, Benowitz NL. Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking. Pharmacology, Biochemistry, and Behavior. PMID 27180107 DOI: 10.1016/J.Pbb.2016.05.002  0.384
2016 Chen J, Bacanu SA, Yu H, Zhao Z, Jia P, Kendler KS, Kranzler HR, Gelernter J, Farrer L, Minica C, Pool R, Milaneschi Y, Boomsma DI, Penninx BW, Tyndale RF, et al. Genetic Relationship between Schizophrenia and Nicotine Dependence. Scientific Reports. 6: 25671. PMID 27164557 DOI: 10.1038/Srep25671  0.309
2016 Benowitz NL, St Helen G, Dempsey DA, Jacob P, Tyndale RF. Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity. Pharmacogenetics and Genomics. PMID 27035242 DOI: 10.1097/Fpc.0000000000000222  0.5
2016 Ware JJ, Chen X, Vink J, Loukola A, Minica C, Pool R, Milaneschi Y, Mangino M, Menni C, Chen J, Peterson RE, Auro K, Lyytikäinen LP, Wedenoja J, Stiby AI, ... ... Tyndale RF, et al. Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2. Scientific Reports. 6: 20092. PMID 26833182 DOI: 10.1038/Srep20092  0.323
2016 Cunningham JA, Kushnir V, Selby P, Tyndale RF, Zawertailo L, Leatherdale ST. Effect of Mailing Nicotine Patches on Tobacco Cessation Among Adult Smokers : A Randomized Clinical Trial. Jama Internal Medicine. PMID 26809849 DOI: 10.1001/Jamainternmed.2015.7792  0.405
2015 Falcone M, Cao W, Bernardo L, Tyndale RF, Loughead J, Lerman C. Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate. Biological Psychiatry. PMID 26805583 DOI: 10.1016/J.Biopsych.2015.11.015  0.386
2015 Wassenaar CA, Zhou Q, Tyndale RF. CYP2A6 genotyping methods and strategies using real-time and endpoint PCR platforms. Pharmacogenomics. PMID 26670214 DOI: 10.2217/pgs.15.156  0.317
2015 Nollen NL, Cox LS, Yu Q, Ellerbeck EF, Scheuermann TS, Benowitz NL, Tyndale RF, Mayo MS, Ahluwalia JS. A clinical trial to examine disparities in quitting between African-American and White adult smokers: Design, accrual, and baseline characteristics. Contemporary Clinical Trials. PMID 26667382 DOI: 10.1016/J.Cct.2015.12.001  0.33
2015 Chenoweth MJ, Sylvestre MP, Contreras G, Novalen M, O'Loughlin J, Tyndale RF. Variation in CYP2A6 and tobacco dependence throughout adolescence and in young adult smokers. Drug and Alcohol Dependence. PMID 26644138 DOI: 10.1016/J.Drugalcdep.2015.11.017  0.471
2015 Di Ciano P, Guranda M, Lagzdins D, Tyndale RF, Gamaleddin I, Selby P, Boileau I, Le Foll B. Varenicline-Induced Elevation of Dopamine in Smokers: A Preliminary [(11)C]-(+)-PHNO PET Study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26442600 DOI: 10.1038/Npp.2015.305  0.394
2015 Loukola A, Buchwald J, Gupta R, Palviainen T, Hällfors J, Tikkanen E, Korhonen T, Ollikainen M, Sarin AP, Ripatti S, Lehtimäki T, Raitakari O, Salomaa V, Rose RJ, Tyndale RF, et al. A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. Plos Genetics. 11: e1005498. PMID 26407342 DOI: 10.1371/Journal.Pgen.1005498  0.395
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZ, Tyndale RF, Kabbani N, Damaj MI. Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice. Plos One. 10: e0137070. PMID 26355604 DOI: 10.1371/Journal.Pone.0137070  0.366
2015 Dubroff JG, Doot RK, Falcone M, Schnoll RA, Ray R, Tyndale RF, Brody AL, Hou C, Schmitz A, Lerman C. Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 56: 1724-9. PMID 26272810 DOI: 10.2967/Jnumed.115.155002  0.45
2015 Kaufmann A, Hitsman B, Goelz PM, Veluz-Wilkins A, Blazekovic S, Powers L, Leone FT, Gariti P, Tyndale RF, Schnoll RA. Rate of Nicotine Metabolism and Smoking Cessation Outcomes in a Community-based Sample of Treatment-Seeking Smokers. Addictive Behaviors. 51: 93-9. PMID 26240944 DOI: 10.1016/J.Addbeh.2015.07.019  0.443
2015 Bergen AW, Michel M, Nishita D, Krasnow R, Javitz HS, Conneely KN, Lessov-Schlaggar CN, Hops H, Zhu AZ, Baurley JW, McClure JB, Hall SM, Baker TB, Conti DV, Benowitz NL, ... ... Tyndale RF, et al. Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption. Plos One. 10: e0126113. PMID 26132489 DOI: 10.1371/Journal.Pone.0126113  0.327
2015 Chenoweth MJ, Schnoll RA, Novalen M, Hawk LW, George TP, Cinciripini PM, Lerman C, Tyndale RF. The Nicotine Metabolite Ratio is Associated With Early Smoking Abstinence Even After Controlling for Factors That Influence the Nicotine Metabolite Ratio. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 26069034 DOI: 10.1093/Ntr/Ntv125  0.482
2015 Tanner JA, Novalen M, Jatlow P, Huestis MA, Murphy SE, Kaprio J, Kankaanpää A, Galanti L, Stefan C, George TP, Benowitz NL, Lerman C, Tyndale RF. Nicotine Metabolite Ratio (3-Hydroxycotinine/Cotinine) in Plasma and Urine by Different Analytical Methods and Laboratories: Implications for Clinical Implementation. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 26014804 DOI: 10.1158/1055-9965.Epi-14-1381  0.488
2015 Foti RS, Tyndale RF, Garcia KL, Sweet DH, Nagar S, Sharan S, Rock DA. "Target-Site" Drug Metabolism and Transport. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1156-68. PMID 25986849 DOI: 10.1124/Dmd.115.064576  0.332
2015 Hamilton DA, Mahoney MC, Novalen M, Chenoweth MJ, Heitjan DF, Lerman C, Tyndale RF, Hawk LW. Test-Retest Reliability and Stability of the Nicotine Metabolite Ratio Among Treatment-Seeking Smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 25732567 DOI: 10.1093/Ntr/Ntv031  0.4
2015 Tanner JA, Chenoweth MJ, Tyndale RF. Pharmacogenetics of nicotine and associated smoking behaviors. Current Topics in Behavioral Neurosciences. 23: 37-86. PMID 25655887 DOI: 10.1007/978-3-319-13665-3_3  0.494
2015 Garcia KL, Coen K, Miksys S, Lê AD, Tyndale RF. Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1910-8. PMID 25652250 DOI: 10.1038/npp.2015.40  0.378
2015 McMillan DM, Tyndale RF. Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1804-12. PMID 25630571 DOI: 10.1038/npp.2015.32  0.332
2015 Lerman C, Schnoll RA, Hawk LW, Cinciripini P, George TP, Wileyto EP, Swan GE, Benowitz NL, Heitjan DF, Tyndale RF. Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial. The Lancet. Respiratory Medicine. 3: 131-8. PMID 25588294 DOI: 10.1016/S2213-2600(14)70294-2  0.359
2015 Bandiera FC, Ross KC, Taghavi S, Delucchi K, Tyndale RF, Benowitz NL. Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 25555385 DOI: 10.1093/Ntr/Ntu337  0.48
2015 Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, Benowitz NL, Tyndale RF. UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 94-104. PMID 25277794 DOI: 10.1158/1055-9965.Epi-14-0804  0.486
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Nicotine plasma levels in adult male ICR mouse after pre-treatment with vehicle or menthol in the withdrawal testing. Plos One. DOI: 10.1371/Journal.Pone.0137070.T004  0.341
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Blockade of menthol’s effects on nicotine acute pharmacological responses after administration in mice. Plos One. DOI: 10.1371/Journal.Pone.0137070.T002  0.364
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Impact of menthol treatment on nicotine pharmacokinetic parameters. Plos One. DOI: 10.1371/Journal.Pone.0137070.T001  0.38
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Effects of menthol on nicotine withdrawal signs. (A) Elevated plus-maze test, (B) Somatic signs and in (C) Hyperalgesia. Plos One. DOI: 10.1371/Journal.Pone.0137070.G005  0.363
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Effects of menthol pretreatment on nicotine-induced antinociception and hypothermia dose-response curves in mice. Plos One. DOI: 10.1371/Journal.Pone.0137070.G004  0.343
2015 Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZX, Tyndale RF, Kabbani N, Damaj MI. Time course of nicotine plasma concentrations in mice pretreated with menthol. Plos One. DOI: 10.1371/Journal.Pone.0137070.G001  0.334
2014 Tani N, Juvonen RO, Raunio H, Fashe M, Leppänen J, Zhao B, Tyndale RF, Rahnasto-Rilla M. Rational design of novel CYP2A6 inhibitors. Bioorganic & Medicinal Chemistry. 22: 6655-64. PMID 25458499 DOI: 10.1016/J.Toxlet.2013.05.407  0.424
2014 Zhu AZ, Zhou Q, Cox LS, Ahluwalia JS, Benowitz NL, Tyndale RF. Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1971-7. PMID 25187485 DOI: 10.1124/Dmd.114.060285  0.438
2014 Chenoweth MJ, Novalen M, Hawk LW, Schnoll RA, George TP, Cinciripini PM, Lerman C, Tyndale RF. Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 23: 1773-82. PMID 25012994 DOI: 10.1158/1055-9965.Epi-14-0427  0.489
2014 Craig EL, Zhao B, Cui JZ, Novalen M, Miksys S, Tyndale RF. Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1447-55. PMID 24980255 DOI: 10.1124/dmd.114.058719  0.348
2014 Bagdas D, Muldoon PP, Zhu AZ, Tyndale RF, Damaj MI. Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. Neuropharmacology. 85: 67-72. PMID 24859605 DOI: 10.1016/J.Neuropharm.2014.05.006  0.382
2014 Khokhar JY, Tyndale RF. Intracerebroventricularly and systemically delivered inhibitor of brain CYP2B (C8-Xanthate), even following chlorpyrifos exposure, reduces chlorpyrifos activation and toxicity in male rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 140: 49-60. PMID 24798379 DOI: 10.1093/Toxsci/Kfu075  0.616
2014 Zhu AZ, Zhou Q, Cox LS, David SP, Ahluwalia JS, Benowitz NL, Tyndale RF. Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers. Clinical Pharmacology and Therapeutics. 96: 256-65. PMID 24733007 DOI: 10.1038/Clpt.2014.88  0.387
2014 Miller RT, Miksys S, Hoffmann E, Tyndale RF. Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys. British Journal of Pharmacology. 171: 3077-88. PMID 24611668 DOI: 10.1111/bph.12652  0.32
2014 Chenoweth MJ, Zhu AZ, Sanderson Cox L, Ahluwalia JS, Benowitz NL, Tyndale RF. Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption. Pharmacogenetics and Genomics. 24: 172-6. PMID 24448396 DOI: 10.1097/Fpc.0000000000000031  0.495
2014 Schnoll RA, George TP, Hawk L, Cinciripini P, Wileyto P, Tyndale RF. The relationship between the nicotine metabolite ratio and three self-report measures of nicotine dependence across sex and race. Psychopharmacology. 231: 2515-23. PMID 24402139 DOI: 10.1007/S00213-013-3421-1  0.46
2014 Piliguian M, Zhu AZ, Zhou Q, Benowitz NL, Ahluwalia JS, Sanderson Cox L, Tyndale RF. Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo. Pharmacogenetics and Genomics. 24: 118-28. PMID 24305170 DOI: 10.1097/Fpc.0000000000000026  0.505
2014 Alsharari SD, Siu EC, Tyndale RF, Damaj MI. Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 16: 18-25. PMID 23884323 DOI: 10.1093/ntr/ntt105  0.357
2014 Wassenaar CA, Ye Y, Cai Q, Aldrich M, Knight J, Spitz MR, Wu X, Blot WJ, Tyndale RF. Abstract 4149: Genetic variation in CYP2A6, a nicotine/nitrosamine metabolism enzyme, influences lung cancer risk in two independent case-control studies of African American smokers Cancer Research. 74: 4149-4149. DOI: 10.1158/1538-7445.Am2014-4149  0.371
2013 David SP, Strong DR, Leventhal AM, Lancaster MA, McGeary JE, Munafò MR, Bergen AW, Swan GE, Benowitz NL, Tyndale RF, Conti DV, Brown RA, Lerman C, Niaura R. Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. Addiction (Abingdon, England). 108: 2202-11. PMID 23941313 DOI: 10.1111/Add.12325  0.374
2013 Zhu AZ, Zhou Q, Cox LS, Ahluwalia JS, Benowitz NL, Tyndale RF. Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. Plos One. 8: e70938. PMID 23936477 DOI: 10.1371/Journal.Pone.0070938  0.489
2013 Dempsey DA, St Helen G, Jacob P, Tyndale RF, Benowitz NL. Genetic and pharmacokinetic determinants of response to transdermal nicotine in white, black, and Asian nonsmokers. Clinical Pharmacology and Therapeutics. 94: 687-94. PMID 23933970 DOI: 10.1038/Clpt.2013.159  0.473
2013 Nollen NL, Mayo MS, Ahluwalia JS, Tyndale RF, Benowitz NL, Faseru B, Buchanan TS, Cox LS. Factors associated with discontinuation of bupropion and counseling among African American light smokers in a randomized clinical trial. Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine. 46: 336-48. PMID 23733379 DOI: 10.1007/S12160-013-9510-X  0.347
2013 Zhu AZ, Renner CC, Hatsukami DK, Benowitz NL, Tyndale RF. CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users. Addiction (Abingdon, England). 108: 1818-28. PMID 23692359 DOI: 10.1111/Add.12250  0.432
2013 Ferguson CS, Miksys S, Palmour RM, Tyndale RF. Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys. Neuropharmacology. 72: 74-81. PMID 23639433 DOI: 10.1016/J.Neuropharm.2013.04.022  0.64
2013 Zhou K, Khokhar JY, Zhao B, Tyndale RF. First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo. Biochemical Pharmacology. 85: 1848-55. PMID 23623752 DOI: 10.1016/J.Bcp.2013.04.014  0.673
2013 Wassenaar CA, Dong Q, Amos CI, Spitz MR, Tyndale RF. Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis. International Journal of Molecular Sciences. 14: 8381-92. PMID 23591849 DOI: 10.3390/Ijms14048381  0.366
2013 Bough KJ, Lerman C, Rose JE, McClernon FJ, Kenny PJ, Tyndale RF, David SP, Stein EA, Uhl GR, Conti DV, Green C, Amur S. Biomarkers for smoking cessation. Clinical Pharmacology and Therapeutics. 93: 526-38. PMID 23588313 DOI: 10.1038/Clpt.2013.57  0.365
2013 Miksys S, Cappendijk SL, Perry WM, Zhao B, Tyndale RF. Nicotine kinetics in zebra finches in vivo and in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1240-6. PMID 23530019 DOI: 10.1124/Dmd.112.050765  0.496
2013 Chenoweth MJ, O'Loughlin J, Sylvestre MP, Tyndale RF. CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers. Pharmacogenetics and Genomics. 23: 232-5. PMID 23462429 DOI: 10.1097/FPC.0b013e32835f834d  0.343
2013 Esterlis I, Hannestad JO, Perkins E, Bois F, D'Souza DC, Tyndale RF, Seibyl JP, Hatsukami DM, Cosgrove KP, O'Malley SS. Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers. The American Journal of Psychiatry. 170: 399-407. PMID 23429725 DOI: 10.1176/Appi.Ajp.2012.12060793  0.351
2013 Zhu AZ, Renner CC, Hatsukami DK, Swan GE, Lerman C, Benowitz NL, Tyndale RF. The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 22: 708-18. PMID 23371292 DOI: 10.1158/1055-9965.Epi-12-1234-T  0.466
2013 Sellings L, Pereira S, Qian C, Dixon-McDougall T, Nowak C, Zhao B, Tyndale RF, van der Kooy D. Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15. The European Journal of Neuroscience. 37: 743-56. PMID 23351035 DOI: 10.1111/Ejn.12099  0.442
2013 Benowitz NL, Zhu AZ, Tyndale RF, Dempsey D, Jacob P. Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state. Pharmacogenetics and Genomics. 23: 135-41. PMID 23344581 DOI: 10.1097/Fpc.0B013E32835D9Ab0  0.35
2013 Faseru B, Nollen NL, Mayo MS, Krebill R, Choi WS, Benowitz NL, Tyndale RF, Okuyemi KS, Ahluwalia JS, Sanderson Cox L. Predictors of cessation in African American light smokers enrolled in a bupropion clinical trial. Addictive Behaviors. 38: 1796-803. PMID 23254230 DOI: 10.1016/J.Addbeh.2012.11.010  0.364
2013 Bergen AW, Javitz HS, Krasnow R, Nishita D, Michel M, Conti DV, Liu J, Lee W, Edlund CK, Hall S, Kwok PY, Benowitz NL, Baker TB, Tyndale RF, Lerman C, et al. Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. Pharmacogenetics and Genomics. 23: 94-103. PMID 23249876 DOI: 10.1097/Fpc.0B013E32835Cdabd  0.41
2013 Miksys S, Tyndale RF. Cytochrome P450-mediated drug metabolism in the brain. Journal of Psychiatry & Neuroscience : Jpn. 38: 152-63. PMID 23199531 DOI: 10.1503/Jpn.120133  0.374
2013 Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP. Imaging changes in synaptic acetylcholine availability in living human subjects. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 78-82. PMID 23160789 DOI: 10.2967/Jnumed.112.111922  0.374
2013 Zhu AZ, Binnington MJ, Renner CC, Lanier AP, Hatsukami DK, Stepanov I, Watson CH, Sosnoff CS, Benowitz NL, Tyndale RF. Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation. Carcinogenesis. 34: 93-101. PMID 23027621 DOI: 10.1093/Carcin/Bgs306  0.318
2013 Renner CC, Lanier AP, Lindgren B, Jensen J, Patten CA, Parascandola M, Benowitz NL, Tyndale RF, Hatsukami DK. Tobacco use among southwestern Alaska Native people. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 401-6. PMID 22949573 DOI: 10.1093/Ntr/Nts137  0.376
2013 Schnoll RA, Wileyto EP, Leone FT, Tyndale RF, Benowitz NL. High dose transdermal nicotine for fast metabolizers of nicotine: a proof of concept placebo-controlled trial. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 348-54. PMID 22589423 DOI: 10.1093/Ntr/Nts129  0.458
2013 Benowitz NL, Dempsey D, Tyndale RF, St Helen G, Jacob P. Dose-independent kinetics with low level exposure to nicotine and cotinine. British Journal of Clinical Pharmacology. 75: 277-9. PMID 22574797 DOI: 10.1111/J.1365-2125.2012.04327.X  0.494
2012 Zhu AZ, Cox LS, Nollen N, Faseru B, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clinical Pharmacology and Therapeutics. 92: 771-7. PMID 23149928 DOI: 10.1038/Clpt.2012.186  0.421
2012 Ferguson CS, Miksys S, Palmour RM, Tyndale RF. Differential effects of nicotine treatment and ethanol self-administration on CYP2A6, CYP2B6 and nicotine pharmacokinetics in African green monkeys. The Journal of Pharmacology and Experimental Therapeutics. 343: 628-37. PMID 22935730 DOI: 10.1124/jpet.112.198564  0.63
2012 Mahar I, Bagot RC, Davoli MA, Miksys S, Tyndale RF, Walker CD, Maheu M, Huang SH, Wong TP, Mechawar N. Developmental hippocampal neuroplasticity in a model of nicotine replacement therapy during pregnancy and breastfeeding. Plos One. 7: e37219. PMID 22615944 DOI: 10.1371/Journal.Pone.0037219  0.438
2012 Binnington MJ, Zhu AZ, Renner CC, Lanier AP, Hatsukami DK, Benowitz NL, Tyndale RF. CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people. Pharmacogenetics and Genomics. 22: 429-40. PMID 22569203 DOI: 10.1097/Fpc.0B013E3283527C1C  0.48
2012 St Helen G, Novalen M, Heitjan DF, Dempsey D, Jacob P, Aziziyeh A, Wing VC, George TP, Tyndale RF, Benowitz NL. Reproducibility of the nicotine metabolite ratio in cigarette smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 1105-14. PMID 22552800 DOI: 10.1158/1055-9965.Epi-12-0236  0.318
2012 Lee W, Ray R, Bergen AW, Swan GE, Thomas P, Tyndale RF, Benowitz NL, Lerman C, Conti DV. DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers. Pharmacogenetics and Genomics. 22: 551-4. PMID 22495174 DOI: 10.1097/Fpc.0B013E3283539062  0.503
2012 Benowitz NL, Renner CC, Lanier AP, Tyndale RF, Hatsukami DK, Lindgren B, Stepanov I, Watson CH, Sosnoff CS, Jacob P. Exposure to nicotine and carcinogens among Southwestern Alaskan Native cigarette smokers and smokeless tobacco users. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 934-42. PMID 22490317 DOI: 10.1158/1055-9965.Epi-11-1178  0.424
2012 Tang DW, Hello B, Mroziewicz M, Fellows LK, Tyndale RF, Dagher A. Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRI. Neuroimage. 60: 2136-43. PMID 22342802 DOI: 10.1016/j.neuroimage.2012.01.119  0.357
2012 Khokhar JY, Tyndale RF. Rat brain CYP2B-enzymatic activation of chlorpyrifos to the oxon mediates cholinergic neurotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 325-35. PMID 22287024 DOI: 10.1093/Toxsci/Kfs029  0.634
2012 Cox LS, Nollen NL, Mayo MS, Choi WS, Faseru B, Benowitz NL, Tyndale RF, Okuyemi KS, Ahluwalia JS. Bupropion for smoking cessation in African American light smokers: a randomized controlled trial. Journal of the National Cancer Institute. 104: 290-8. PMID 22282543 DOI: 10.1093/Jnci/Djr513  0.37
2012 Kohli U, Pandharipande P, Muszkat M, Sofowora GG, Friedman EA, Scheinin M, Wood AJ, Ely EW, Tyndale RF, Choi L, Stein CM, Kurnik D. CYP2A6 genetic variation and dexmedetomidine disposition. European Journal of Clinical Pharmacology. 68: 937-42. PMID 22271297 DOI: 10.1007/S00228-011-1208-Z  0.349
2012 Liu T, David SP, Tyndale RF, Wang H, Yu XQ, Chen W, Zhou Q, Chen WQ. Relationship between amounts of daily cigarette consumption and abdominal obesity moderated by CYP2A6 genotypes in Chinese male current smokers. Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine. 43: 253-61. PMID 22160797 DOI: 10.1007/S12160-011-9318-5  0.395
2012 Mann A, Miksys SL, Gaedigk A, Kish SJ, Mash DC, Tyndale RF. The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients. Neurobiology of Aging. 33: 2160-71. PMID 21958961 DOI: 10.1016/J.Neurobiolaging.2011.08.014  0.52
2012 Zhu AZX, Tyndale RF. Nicotine Metabolism and its Implications Metabolism of Drugs and Other Xenobiotics. 465-492. DOI: 10.1002/9783527630905.ch17  0.335
2011 Ferguson CS, Tyndale RF. Cytochrome P450 enzymes in the brain: emerging evidence of biological significance. Trends in Pharmacological Sciences. 32: 708-14. PMID 21975165 DOI: 10.1016/j.tips.2011.08.005  0.55
2011 Cunningham JA, Leatherdale ST, Selby PL, Tyndale RF, Zawertailo L, Kushnir V. Randomized controlled trial of mailed Nicotine Replacement Therapy to Canadian smokers: study protocol. Bmc Public Health. 11: 741. PMID 21955930 DOI: 10.1186/1471-2458-11-741  0.392
2011 Ferguson CS, Miksys S, Palmour R, Tyndale RF. Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2233-41. PMID 21868470 DOI: 10.1124/Dmd.111.040378  0.61
2011 Wassenaar CA, Dong Q, Wei Q, Amos CI, Spitz MR, Tyndale RF. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. Journal of the National Cancer Institute. 103: 1342-6. PMID 21747048 DOI: 10.1093/Jnci/Djr237  0.371
2011 Falcone M, Jepson C, Benowitz N, Bergen AW, Pinto A, Wileyto EP, Baldwin D, Tyndale RF, Lerman C, Ray R. Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 13: 498-503. PMID 21385908 DOI: 10.1093/Ntr/Ntr012  0.367
2011 Cox LS, Faseru B, Mayo MS, Krebill R, Snow TS, Bronars CA, Nollen NL, Choi WS, Okuyemi KS, Salzman GA, Benowitz NL, Tyndale RF, Ahluwalia JS. Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data. Trials. 12: 22. PMID 21266057 DOI: 10.1186/1745-6215-12-22  0.4
2011 Strasser AA, Benowitz NL, Pinto AG, Tang KZ, Hecht SS, Carmella SG, Tyndale RF, Lerman CE. Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 234-8. PMID 21212060 DOI: 10.1158/1055-9965.Epi-10-0674  0.456
2011 Khokhar JY, Tyndale RF. Drug metabolism within the brain changes drug response: selective manipulation of brain CYP2B alters propofol effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 692-700. PMID 21107310 DOI: 10.1038/Npp.2010.202  0.655
2011 Mwenifumbo JC, Tyndale RF. DSM-IV, ICD-10 and FTND: Discordant Tobacco Dependence Diagnoses in Adult Smokers Journal of Addiction Research & Therapy. 2. DOI: 10.4172/2155-6105.1000105  0.34
2010 Ho MK, Goldman D, Heinz A, Kaprio J, Kreek MJ, Li MD, Munafò MR, Tyndale RF. Breaking barriers in the genomics and pharmacogenetics of drug addiction. Clinical Pharmacology and Therapeutics. 88: 779-91. PMID 20981002 DOI: 10.1038/Clpt.2010.175  0.591
2010 Khokhar JY, Miksys SL, Tyndale RF. Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. Brain Research. 1348: 1-9. PMID 20599831 DOI: 10.1016/J.Brainres.2010.06.035  0.699
2010 Mann A, Tyndale RF. Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells. The European Journal of Neuroscience. 31: 1185-93. PMID 20345925 DOI: 10.1111/J.1460-9568.2010.07142.X  0.619
2010 Lerman C, Jepson C, Wileyto EP, Patterson F, Schnoll R, Mroziewicz M, Benowitz N, Tyndale RF. Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy. Clinical Pharmacology and Therapeutics. 87: 553-7. PMID 20336063 DOI: 10.1038/Clpt.2010.3  0.434
2010 Al Koudsi N, Tyndale RF. Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 40: 381-92. PMID 20307138 DOI: 10.3109/00498251003713958  0.416
2010 Mwenifumbo JC, Zhou Q, Benowitz NL, Sellers EM, Tyndale RF. New CYP2A6 gene deletion and conversion variants in a population of Black African descent. Pharmacogenomics. 11: 189-98. PMID 20136358 DOI: 10.2217/Pgs.09.144  0.405
2010 Khokhar JY, Ferguson CS, Zhu AZ, Tyndale RF. Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. Annual Review of Pharmacology and Toxicology. 50: 39-61. PMID 20055697 DOI: 10.1146/Annurev.Pharmtox.010909.105826  0.721
2010 Zawertailo LA, Tyndale RF, Busto U, Sellers EM. Effect of metabolic blockade on the psychoactive effects of dextromethorphan. Human Psychopharmacology. 25: 71-9. PMID 20041473 DOI: 10.1002/Hup.1086  0.364
2010 Grieder TE, Sellings LH, Vargas-Perez H, Ting-A-Kee R, Siu EC, Tyndale RF, van der Kooy D. Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 943-54. PMID 20032966 DOI: 10.1038/Npp.2009.198  0.418
2010 Al Koudsi N, Hoffmann EB, Assadzadeh A, Tyndale RF. Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors. European Journal of Clinical Pharmacology. 66: 239-51. PMID 20012030 DOI: 10.1007/S00228-009-0762-0  0.417
2010 Koudsi NA, O'Loughlin J, Rodriguez D, Audrain-McGovern J, Tyndale RF. The genetic aspects of nicotine metabolism and their impact on adolescent nicotine dependence Journal of Pediatric Biochemistry. 1: 105-123. DOI: 10.3233/JPB-2010-0014  0.318
2009 Ho MK, Faseru B, Choi WS, Nollen NL, Mayo MS, Thomas JL, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF. Utility and relationships of biomarkers of smoking in African-American light smokers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 3426-34. PMID 19959692 DOI: 10.1158/1055-9965.Epi-09-0956  0.681
2009 Thomas PD, Mi H, Swan GE, Lerman C, Benowitz N, Tyndale RF, Bergen AW, Conti DV. A systems biology network model for genetic association studies of nicotine addiction and treatment. Pharmacogenetics and Genomics. 19: 538-51. PMID 19525886 DOI: 10.1097/Fpc.0B013E32832E2Ced  0.377
2009 Al Koudsi N, Ahluwalia JS, Lin SK, Sellers EM, Tyndale RF. A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo. The Pharmacogenomics Journal. 9: 274-82. PMID 19365400 DOI: 10.1038/Tpj.2009.11  0.363
2009 Swan GE, Lessov-Schlaggar CN, Bergen AW, He Y, Tyndale RF, Benowitz NL. Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine. Pharmacogenetics and Genomics. 19: 388-98. PMID 19300303 DOI: 10.1097/Fpc.0B013E32832A404F  0.394
2009 Yue J, Khokhar J, Miksys S, Tyndale RF. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. European Journal of Pharmacology. 609: 88-95. PMID 19285975 DOI: 10.1016/J.Ejphar.2009.03.015  0.691
2009 Ho MK, Mwenifumbo JC, Al Koudsi N, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF. Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers. Clinical Pharmacology and Therapeutics. 85: 635-43. PMID 19279561 DOI: 10.1038/Clpt.2009.19  0.708
2009 Mwenifumbo JC, Tyndale RF. Molecular genetics of nicotine metabolism. Handbook of Experimental Pharmacology. 235-59. PMID 19184652 DOI: 10.1007/978-3-540-69248-5_9  0.474
2009 Ray R, Tyndale RF, Lerman C. Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes. Journal of Neurogenetics. 23: 252-61. PMID 19169923 DOI: 10.1080/01677060802572887  0.421
2009 Schnoll RA, Patterson F, Wileyto EP, Tyndale RF, Benowitz N, Lerman C. Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study. Pharmacology, Biochemistry, and Behavior. 92: 6-11. PMID 19000709 DOI: 10.1016/J.Pbb.2008.10.016  0.496
2009 Miksys S, Tyndale RF. Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 634-40. PMID 18668033 DOI: 10.1038/Npp.2008.110  0.38
2009 Desta Z, Tyndale R, Hoffmann E, Kreutz Y, Nguyen A, Flockhart D. Cytochrome P450 (CYP) 2A6 Genetic Variation Predicts Letrozole Plasma Concentrations in Postmenopausal Women with Breast Cancer. Cancer Research. 69: 5160-5160. DOI: 10.1158/0008-5472.Sabcs-09-5160  0.309
2009 Mwenifumbo JC, Sellers EM, Tyndale RF. Corrigendum to "Nicotine metabolism and CYP2A6 activity in a population of black African descent: Impact of gender and light smoking" [Drug Alcohol Depend. 89/1 (2007) 24-33] (DOI:10.1016/j.drugalcdep.2006.11.012) Drug and Alcohol Dependence. 104: 185. DOI: 10.1016/J.Drugalcdep.2009.04.004  0.373
2008 Mann A, Miksys S, Lee A, Mash DC, Tyndale RF. Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment. Neuropharmacology. 55: 1147-55. PMID 18687346 DOI: 10.1016/J.Neuropharm.2008.07.017  0.687
2008 Conti DV, Lee W, Li D, Liu J, Van Den Berg D, Thomas PD, Bergen AW, Swan GE, Tyndale RF, Benowitz NL, Lerman C. Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Human Molecular Genetics. 17: 2834-48. PMID 18593715 DOI: 10.1093/Hmg/Ddn181  0.308
2008 Patterson F, Schnoll RA, Wileyto EP, Pinto A, Epstein LH, Shields PG, Hawk LW, Tyndale RF, Benowitz N, Lerman C. Toward personalized therapy for smoking cessation: a randomized placebo-controlled trial of bupropion. Clinical Pharmacology and Therapeutics. 84: 320-5. PMID 18388868 DOI: 10.1038/Clpt.2008.57  0.403
2008 Shram MJ, Siu EC, Li Z, Tyndale RF, Lê AD. Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats. Psychopharmacology. 198: 181-90. PMID 18385986 DOI: 10.1007/S00213-008-1115-X  0.42
2008 Mwenifumbo JC, Al Koudsi N, Ho MK, Zhou Q, Hoffmann EB, Sellers EM, Tyndale RF. Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. Human Mutation. 29: 679-88. PMID 18360915 DOI: 10.1002/Humu.20698  0.685
2008 Ho MK, Mwenifumbo JC, Zhao B, Gillam EM, Tyndale RF. A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent. Pharmacogenetics and Genomics. 18: 67-75. PMID 18216723 DOI: 10.1097/Fpc.0B013E3282F3606E  0.691
2008 Yue J, Miksys S, Hoffmann E, Tyndale RF. Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course. Journal of Psychiatry & Neuroscience : Jpn. 33: 54-63. PMID 18197273  0.331
2008 Siu EC, Tyndale RF. Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice. The Journal of Pharmacology and Experimental Therapeutics. 324: 992-9. PMID 18065502 DOI: 10.1124/Jpet.107.133900  0.482
2008 Mwenifumbo JC, Lessov-Schlaggar CN, Zhou Q, Krasnow RE, Swan GE, Benowitz NL, Tyndale RF. Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism. Clinical Pharmacology and Therapeutics. 83: 115-21. PMID 17522595 DOI: 10.1038/sj.clpt.6100246  0.336
2007 Ring HZ, Valdes AM, Nishita DM, Prasad S, Jacob P, Tyndale RF, Swan GE, Benowitz NL. Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism. Pharmacogenetics and Genomics. 17: 1007-15. PMID 18004205 DOI: 10.1097/01.Fpc.0000220560.59972.33  0.488
2007 Mwenifumbo JC, Tyndale RF. Genetic variability in CYP2A6 and the pharmacokinetics of nicotine. Pharmacogenomics. 8: 1385-402. PMID 17979512 DOI: 10.2217/14622416.8.10.1385  0.51
2007 Wall TL, Schoedel K, Ring HZ, Luczak SE, Katsuyoshi DM, Tyndale RF. Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 9: S459-74. PMID 17978975 DOI: 10.1080/14622200701587045  0.689
2007 Lee AM, Jepson C, Shields PG, Benowitz N, Lerman C, Tyndale RF. CYP2B6 genotype does not alter nicotine metabolism, plasma levels, or abstinence with nicotine replacement therapy. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1312-4. PMID 17548706 DOI: 10.1158/1055-9965.Epi-07-0188  0.468
2007 Strasser AA, Malaiyandi V, Hoffmann E, Tyndale RF, Lerman C. An association of CYP2A6 genotype and smoking topography. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 9: 511-8. PMID 17454707 DOI: 10.1080/14622200701239605  0.362
2007 Ho MK, Tyndale RF. Overview of the pharmacogenomics of cigarette smoking. The Pharmacogenomics Journal. 7: 81-98. PMID 17224913 DOI: 10.1038/sj.tpj.6500436  0.665
2007 Siu EC, Tyndale RF. Non-nicotinic therapies for smoking cessation. Annual Review of Pharmacology and Toxicology. 47: 541-64. PMID 17209799 DOI: 10.1146/Annurev.Pharmtox.47.120505.105354  0.44
2007 Mwenifumbo JC, Sellers EM, Tyndale RF. Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking. Drug and Alcohol Dependence. 89: 24-33. PMID 17161559 DOI: 10.1016/J.Drugalcdep.2006.11.012  0.411
2007 Siu EC, Tyndale RF. Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice. Molecular Pharmacology. 71: 826-34. PMID 17158199 DOI: 10.1124/Mol.106.032086  0.444
2007 Audrain-McGovern J, Al Koudsi N, Rodriguez D, Wileyto EP, Shields PG, Tyndale RF. The role of CYP2A6 in the emergence of nicotine dependence in adolescents. Pediatrics. 119: e264-74. PMID 17130279 DOI: 10.1542/Peds.2006-1583  0.459
2007 Damaj MI, Siu EC, Sellers EM, Tyndale RF, Martin BR. Inhibition of nicotine metabolism by methoxysalen: Pharmacokinetic and pharmacological studies in mice. The Journal of Pharmacology and Experimental Therapeutics. 320: 250-7. PMID 17021260 DOI: 10.1124/Jpet.106.111237  0.472
2007 Matta SG, Balfour DJ, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, ... ... Tyndale RF, et al. Guidelines on nicotine dose selection for in vivo research. Psychopharmacology. 190: 269-319. PMID 16896961 DOI: 10.1007/S00213-006-0441-0  0.327
2006 Benowitz NL, Swan GE, Jacob P, Lessov-Schlaggar CN, Tyndale RF. CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clinical Pharmacology and Therapeutics. 80: 457-67. PMID 17112802 DOI: 10.1016/j.clpt.2006.08.011  0.379
2006 Malaiyandi V, Goodz SD, Sellers EM, Tyndale RF. CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 1812-9. PMID 17035386 DOI: 10.1158/1055-9965.Epi-05-0723  0.486
2006 Miksys S, Tyndale RF. Nicotine induces brain CYP enzymes: relevance to Parkinson's disease. Journal of Neural Transmission. Supplementum. 177-80. PMID 17017527  0.32
2006 Quik M, Parameswaran N, McCallum SE, Bordia T, Bao S, McCormack A, Kim A, Tyndale RF, Langston JW, Di Monte DA. Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates. Journal of Neurochemistry. 98: 1866-75. PMID 16882311 DOI: 10.1111/J.1471-4159.2006.04078.X  0.44
2006 Lee AM, Tyndale RF. Drugs and genotypes: how pharmacogenetic information could improve smoking cessation treatment. Journal of Psychopharmacology (Oxford, England). 20: 7-14. PMID 16785264 DOI: 10.1177/1359786806066039  0.437
2006 Lerman C, Tyndale R, Patterson F, Wileyto EP, Shields PG, Pinto A, Benowitz N. Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation. Clinical Pharmacology and Therapeutics. 79: 600-8. PMID 16765148 DOI: 10.1016/J.Clpt.2006.02.006  0.394
2006 Lee AM, Yue J, Tyndale RF. In vivo and in vitro characterization of chlorzoxazone metabolism and hepatic CYP2E1 levels in African Green monkeys: induction by chronic nicotine treatment. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1508-15. PMID 16763012 DOI: 10.1124/Dmd.106.010363  0.487
2006 Al Koudsi N, Mwenifumbo JC, Sellers EM, Benowitz NL, Swan GE, Tyndale RF. Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics. European Journal of Clinical Pharmacology. 62: 481-4. PMID 16758265 DOI: 10.1007/S00228-006-0113-3  0.472
2006 Lee AM, Miksys S, Tyndale RF. Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein. British Journal of Pharmacology. 148: 786-94. PMID 16751792 DOI: 10.1038/sj.bjp.0706787  0.387
2006 Siu EC, Wildenauer DB, Tyndale RF. Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5. Psychopharmacology. 184: 401-8. PMID 16485141 DOI: 10.1007/S00213-006-0306-6  0.485
2006 Joshi M, Tyndale RF. Induction and recovery time course of rat brain CYP2E1 after nicotine treatment. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 647-52. PMID 16434548 DOI: 10.1124/Dmd.105.008029  0.495
2006 McCallum SE, Parameswaran N, Bordia T, Fan H, Tyndale RF, Langston JW, McIntosh JM, Quik M. Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment. Journal of Neurochemistry. 96: 1028-41. PMID 16412091 DOI: 10.1111/J.1471-4159.2005.03646.X  0.39
2006 Malaiyandi V, Lerman C, Benowitz NL, Jepson C, Patterson F, Tyndale RF. Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy. Molecular Psychiatry. 11: 400-9. PMID 16402128 DOI: 10.1038/Sj.Mp.4001794  0.413
2006 Joshi M, Tyndale RF. Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine. Neuropharmacology. 50: 568-75. PMID 16368115 DOI: 10.1016/j.neuropharm.2005.11.001  0.388
2006 Lee AM, Miksys S, Palmour R, Tyndale RF. CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment. Neuropharmacology. 50: 441-50. PMID 16309716 DOI: 10.1016/J.Neuropharm.2005.10.003  0.475
2006 Tyndale RF, Sellers EM. Modifying the metabolism of nicotine as a therapeutic strategy Novartis Foundation Symposium. 275: 235-244.  0.321
2005 Al Koudsi N, Tyndale RF. Genetic influences on smoking: a brief review. Therapeutic Drug Monitoring. 27: 704-9. PMID 16404798 DOI: 10.1097/01.Ftd.0000179842.63515.C6  0.45
2005 Miksys SL, Cheung C, Gonzalez FJ, Tyndale RF. Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1495-502. PMID 16033950 DOI: 10.1124/Dmd.105.005488  0.322
2005 Mwenifumbo JC, Myers MG, Wall TL, Lin SK, Sellers EM, Tyndale RF. Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method. Pharmacogenetics and Genomics. 15: 189-92. PMID 15861044 DOI: 10.1097/01213011-200503000-00008  0.329
2005 Swan GE, Benowitz NL, Lessov CN, Jacob P, Tyndale RF, Wilhelmsen K. Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence. Pharmacogenetics and Genomics. 15: 115-25. PMID 15861035 DOI: 10.1097/01213011-200502000-00007  0.451
2005 Malaiyandi V, Sellers EM, Tyndale RF. Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clinical Pharmacology and Therapeutics. 77: 145-58. PMID 15735609 DOI: 10.1016/J.Clpt.2004.10.011  0.345
2005 Grabus SD, Martin BR, Batman AM, Tyndale RF, Sellers E, Damaj MI. Nicotine physical dependence and tolerance in the mouse following chronic oral administration. Psychopharmacology. 178: 183-92. PMID 15365686 DOI: 10.1007/S00213-004-2007-3  0.45
2005 DEMPSEY D, JACOBIII P, TYNDALE R, HOFFMANN E, BENOWITZ N. CYP2A6 genotype and toxicity of nicotine in never smokers Clinical Pharmacology & Therapeutics. 77: P4-P4. DOI: 10.1016/j.clpt.2004.11.020  0.365
2004 O'Loughlin J, Paradis G, Kim W, DiFranza J, Meshefedjian G, McMillan-Davey E, Wong S, Hanley J, Tyndale RF. Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. Tobacco Control. 13: 422-8. PMID 15564629 DOI: 10.1136/tc.2003.007070  0.312
2004 Swan GE, Benowitz NL, Jacob P, Lessov CN, Tyndale RF, Wilhelmsen K, Krasnow RE, McElroy MR, Moore SE, Wambach M. Pharmacogenetics of nicotine metabolism in twins: methods and procedures. Twin Research : the Official Journal of the International Society For Twin Studies. 7: 435-48. PMID 15527659 DOI: 10.1375/1369052042335269  0.465
2004 Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, Tyndale RF. Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. Pharmacogenetics. 14: 615-26. PMID 15475735 DOI: 10.1097/00008571-200409000-00006  0.71
2004 Dempsey D, Tutka P, Jacob P, Allen F, Schoedel K, Tyndale RF, Benowitz NL. Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity. Clinical Pharmacology and Therapeutics. 76: 64-72. PMID 15229465 DOI: 10.1016/J.Clpt.2004.02.011  0.72
2004 De Luca V, Wong AH, Muller DJ, Wong GW, Tyndale RF, Kennedy JL. Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1522-6. PMID 15100704 DOI: 10.1038/Sj.Npp.1300466  0.415
2003 Sellers EM, Ramamoorthy Y, Zeman MV, Djordjevic MV, Tyndale RF. The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 5: 891-9. PMID 14668073 DOI: 10.1080/14622200310001615231  0.4
2003 Sellers EM, Tyndale RF, Fernandes LC. Decreasing smoking behaviour and risk through CYP2A6 inhibition. Drug Discovery Today. 8: 487-93. PMID 12818518 DOI: 10.1016/S1359-6446(03)02704-1  0.322
2003 Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Neuropharmacology. 45: 122-32. PMID 12814665 DOI: 10.1016/S0028-3908(03)00136-9  0.311
2003 Howard LA, Ahluwalia JS, Lin SK, Sellers EM, Tyndale RF. CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence. Pharmacogenetics. 13: 321-8. PMID 12777962 DOI: 10.1097/00008571-200306000-00003  0.657
2003 Zhang W, Ramamoorthy Y, Tyndale RF, Sellers EM. Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 768-72. PMID 12756210 DOI: 10.1124/Dmd.31.6.768  0.37
2003 Micu AL, Miksys S, Sellers EM, Koop DR, Tyndale RF. Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism. The Journal of Pharmacology and Experimental Therapeutics. 306: 941-7. PMID 12750430 DOI: 10.1124/Jpet.103.052183  0.463
2003 Howard LA, Miksys S, Hoffmann E, Mash D, Tyndale RF. Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. British Journal of Pharmacology. 138: 1376-86. PMID 12711639 DOI: 10.1038/Sj.Bjp.0705146  0.65
2003 Schoedel KA, Tyndale RF. Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: summary and implications. Biochimica Et Biophysica Acta. 1619: 283-90. PMID 12573488 DOI: 10.1016/S0304-4165(02)00487-7  0.726
2003 Schoedel KA, Sellers EM, Palmour R, Tyndale RF. Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration. Molecular Pharmacology. 63: 96-104. PMID 12488541 DOI: 10.1124/Mol.63.1.96  0.743
2002 Ahijevych KL, Tyndale RF, Dhatt RK, Weed HG, Browning KK. Factors influencing cotinine half-life during smoking abstinence in African American and Caucasian women. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 4: 423-31. PMID 12521401 DOI: 10.1080/1462220021000018452  0.377
2002 Goodz SD, Tyndale RF. Genotyping human CYP2A6 variants. Methods in Enzymology. 357: 59-69. PMID 12424898 DOI: 10.1016/S0076-6879(02)57666-7  0.432
2002 Xu C, Goodz S, Sellers EM, Tyndale RF. CYP2A6 genetic variation and potential consequences. Advanced Drug Delivery Reviews. 54: 1245-56. PMID 12406643 DOI: 10.1016/S0169-409X(02)00065-0  0.327
2002 Ramamoorthy Y, Yu AM, Suh N, Haining RL, Tyndale RF, Sellers EM. Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Biochemical Pharmacology. 63: 2111-9. PMID 12110370 DOI: 10.1016/S0006-2952(02)01028-6  0.366
2002 Zhang W, Ramamoorthy Y, Tyndale RF, Glick SD, Maisonneuve IM, Kuehne ME, Sellers EM. Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 663-9. PMID 12019193 DOI: 10.1124/Dmd.30.6.663  0.344
2002 Howard LA, Sellers EM, Tyndale RF. The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence. Pharmacogenomics. 3: 185-99. PMID 11972441 DOI: 10.1517/14622416.3.2.185  0.633
2002 Tyndale RF, Sellers EM. Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Therapeutic Drug Monitoring. 24: 163-71. PMID 11805739 DOI: 10.1097/00007691-200202000-00026  0.494
2001 Howard LA, Micu AL, Sellers EM, Tyndale RF. Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver. The Journal of Pharmacology and Experimental Therapeutics. 299: 542-50. PMID 11602665  0.681
2001 Schoedel KA, Sellers EM, Tyndale RF. Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain. Biochemical Pharmacology. 62: 1025-36. PMID 11597571 DOI: 10.1016/S0006-2952(01)00744-4  0.715
2001 Ramamoorthy Y, Tyndale RF, Sellers EM. Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics. 11: 477-87. PMID 11505218 DOI: 10.1097/00008571-200108000-00003  0.35
2001 Petrie J, Sapp DW, Tyndale RF, Park MK, Fanselow M, Olsen RW. Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. Alcoholism, Clinical and Experimental Research. 25: 819-28. PMID 11410716 DOI: 10.1111/J.1530-0277.2001.Tb02285.X  0.67
2001 Tyndale RF, Sellers EM. Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 548-52. PMID 11259349  0.398
2001 Wong JM, Harper PA, Meyer UA, Bock KW, Morike K, Lagueux J, Ayotte P, Tyndale RF, Sellers EM, Manchester DK, Okey AB. Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro. Pharmacogenetics. 11: 85-94. PMID 11207035 DOI: 10.1097/00008571-200102000-00010  0.304
2001 BENOWITZ N, GRIFFIN C, TYNDALE R. Deficient C-oxidation of nicotine continued Clinical Pharmacology & Therapeutics. 70: 561-566. DOI: 10.1016/S0009-9236(01)90120-1  0.351
2000 Rao Y, Hoffmann E, Zia M, Bodin L, Zeman M, Sellers EM, Tyndale RF. Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking. Molecular Pharmacology. 58: 747-55. PMID 10999944 DOI: 10.1124/Mol.58.4.747  0.336
2000 Sellers EM, Kaplan HL, Tyndale RF. Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking. Clinical Pharmacology and Therapeutics. 68: 35-43. PMID 10945314 DOI: 10.1067/Mcp.2000.107651  0.393
2000 Miksys S, Rao Y, Sellers EM, Kwan M, Mendis D, Tyndale RF. Regional and cellular distribution of CYP2D subfamily members in rat brain. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 30: 547-64. PMID 10923858 DOI: 10.1080/004982500406390  0.331
2000 Kathiramalainathan K, Kaplan HL, Romach MK, Busto UE, Li NY, Säwe J, Tyndale RF, Sellers EM. Inhibition of cytochrome P450 2D6 modifies codeine abuse liability. Journal of Clinical Psychopharmacology. 20: 435-44. PMID 10917405 DOI: 10.1097/00004714-200008000-00008  0.315
2000 Sellers EM, Tyndale RF. Mimicking gene defects to treat drug dependence. Annals of the New York Academy of Sciences. 909: 233-46. PMID 10911933 DOI: 10.1111/J.1749-6632.2000.Tb06685.X  0.421
2000 Miksys S, Hoffmann E, Tyndale RF. Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment. Biochemical Pharmacology. 59: 1501-11. PMID 10799646  0.392
2000 Romach MK, Otton SV, Somer G, Tyndale RF, Sellers EM. Cytochrome P450 2D6 and treatment of codeine dependence. Journal of Clinical Psychopharmacology. 20: 43-5. PMID 10653207 DOI: 10.1097/00004714-200002000-00008  0.333
1999 Tyndale RF, Pianezza ML, Sellers EM. A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 1: S63-7; discussion S6. PMID 11768189 DOI: 10.1080/14622299050011831  0.503
1999 Ozdemir V, Tyndale RF, Reed K, Herrmann N, Sellers EM, Kalow W, Naranjo CA. Paroxetine steady-state plasma concentration in relation to CYP2D6 genotype in extensive metabolizers. Journal of Clinical Psychopharmacology. 19: 472-5. PMID 10505591 DOI: 10.1097/00004714-199910000-00014  0.563
1999 TYNDALE R, LI Y, KAPLAN H, SELLERS E. Inhibition of nicotine's metabolism: A potential new treatment for tobacco dependence1 Clinical Pharmacology & Therapeutics. 65: 145-145. DOI: 10.1016/S0009-9236(99)80112-X  0.335
1998 Zawertailo LA, Kaplan HL, Busto UE, Tyndale RF, Sellers EM. Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study. Journal of Clinical Psychopharmacology. 18: 332-7. PMID 9690700 DOI: 10.1097/00004714-199808000-00014  0.351
1998 Pianezza ML, Sellers EM, Tyndale RF. Nicotine metabolism defect reduces smoking. Nature. 393: 750. PMID 9655391 DOI: 10.1038/31623  0.396
1997 Tyndale RF, Bhave SV, Hoffmann E, Hoffmann PL, Tabakoff B, Tobin AJ, Olsen RW. Pentobarbital decreases the gamma-aminobutyric acidA receptor subunit gamma-2 long/short mRNA ratio by a mechanism distinct from receptor occupation. The Journal of Pharmacology and Experimental Therapeutics. 283: 350-7. PMID 9336343  0.616
1997 Messina ES, Tyndale RF, Sellers EM. A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. The Journal of Pharmacology and Experimental Therapeutics. 282: 1608-14. PMID 9316878  0.363
1995 Greger V, Knoll JH, Woolf E, Glatt K, Tyndale RF, DeLorey TM, Olsen RW, Tobin AJ, Sikela JM, Nakatsu Y. The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. Genomics. 26: 258-64. PMID 7601451 DOI: 10.1016/0888-7543(95)80209-5  0.748
1994 Tyndale RF, Hales TG, Olsen RW, Tobin AJ. Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5417-28. PMID 8083745 DOI: 10.1523/Jneurosci.14-09-05417.1994  0.619
1994 Tyndale R, Hales T, Olsen R, Tobin A. Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines The Journal of Neuroscience. 14: 5417-5428. DOI: 10.1523/JNEUROSCI.14-09-05417.1994  0.605
1993 Nakatsu Y, Tyndale RF, DeLorey TM, Durham-Pierre D, Gardner JM, McDanel HJ, Nguyen Q, Wagstaff J, Lalande M, Sikela JM. A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature. 364: 448-50. PMID 8392662 DOI: 10.1038/364448a0  0.662
1991 Tyndale RF, Kalow W, Inaba T. Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase). British Journal of Clinical Pharmacology. 31: 655-60. PMID 1867960 DOI: 10.1111/J.1365-2125.1991.Tb05588.X  0.561
1991 Tyndale R, Aoyama T, Broly F, Matsunaga T, Inaba T, Kalow W, Gelboin HV, Meyer UA, Gonzalez FJ. Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. Pharmacogenetics. 1: 26-32. PMID 1844820 DOI: 10.1097/00008571-199110000-00005  0.607
1990 Tyndale RF, Gonzalez FJ, Hardwick JP, Kalow W, Inaba T. Sparteine metabolism capacity in human liver: structural variants of human P450IID6 as assessed by immunochemistry. Pharmacology & Toxicology. 67: 14-8. PMID 2395811 DOI: 10.1111/J.1600-0773.1990.Tb00774.X  0.592
1990 Niznik HB, Tyndale RF, Sallee FR, Gonzalez FJ, Hardwick JP, Inaba T, Kalow W. The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins. Archives of Biochemistry and Biophysics. 276: 424-32. PMID 2306106 DOI: 10.1016/0003-9861(90)90741-G  0.507
1990 Inaba T, Tyndale RF, Niznik HB, Kalow W. Cytochrome p45 0IID6 (debrisoquine hydroxylase): inhibition studies in liver and brain European Journal of Pharmacology. 183: 661. DOI: 10.1016/0014-2999(90)92448-R  0.577
Low-probability matches (unlikely to be authored by this person)
2019 Nollen NL, Mayo MS, Cox LS, Benowitz NL, Tyndale RF, Ellerbeck EF, Scheuermann TS, Ahluwalia JS. Factors that Explain Differences in Abstinence between Black and White Smokers: A Prospective Intervention Study. Journal of the National Cancer Institute. PMID 30657926 DOI: 10.1093/Jnci/Djz001  0.3
2014 Leventhal AM, Lee W, Bergen AW, Swan GE, Tyndale RF, Lerman C, Conti DV. Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome. Drug and Alcohol Dependence. 138: 109-17. PMID 24667010 DOI: 10.1016/J.Drugalcdep.2014.02.016  0.3
2001 Mash DC, Kovera CA, Pablo J, Tyndale R, Ervin FR, Kamlet JD, Hearn WL. Ibogaine in the treatment of heroin withdrawal. The Alkaloids. Chemistry and Biology. 56: 155-71. PMID 11705106 DOI: 10.1016/S0099-9598(01)56012-5  0.3
2017 Shahab L, Mortimer E, Bauld L, McGowan JA, McNeill A, Tyndale RF. Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop Smoking Services in England. Scientific Reports. 7: 17613. PMID 29242560 DOI: 10.1038/s41598-017-17994-8  0.299
2018 Borrie AE, Rose RV, Choi YH, Perera FE, Read N, Sexton T, Lock M, Vandenberg TA, Hahn K, Dinniwell R, Younus J, Logan D, Potvin K, Yaremko B, Yu E, ... ... Tyndale RF, et al. Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer. Breast Cancer Research and Treatment. PMID 30094551 DOI: 10.1007/S10549-018-4910-Z  0.298
2022 Cunningham JA, Leatherdale ST, Chaiton M, Tyndale RF, Schell C, Godinho A. Concentrated distribution of nicotine patches to a town with high smoking rates - any evidence of large impacts on tobacco cessation? Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 36264570 DOI: 10.1093/ntr/ntac244  0.297
2011 Liu T, David SP, Tyndale RF, Wang H, Zhou Q, Ding P, He YH, Yu XQ, Chen W, Crump C, Wen XZ, Chen WQ. Associations of CYP2A6 genotype with smoking behaviors in southern China. Addiction (Abingdon, England). 106: 985-94. PMID 21205058 DOI: 10.1111/J.1360-0443.2010.03353.X  0.297
2019 Chen J, Loukola A, Gillespie NA, Peterson R, Jia P, Riley B, Maes H, Dick DM, Kendler KS, Damaj MI, Miles MF, Zhao Z, Li MD, Vink JM, Minica CC, ... ... Tyndale R, et al. Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31294817 DOI: 10.1093/Ntr/Ntz099  0.297
2018 Peng AR, Schnoll R, Hawk LW, Cinciripini P, George TP, Lerman C, Tyndale RF. Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes. Drug and Alcohol Dependence. 190: 72-81. PMID 29986268 DOI: 10.1016/J.Drugalcdep.2018.04.035  0.296
2002 Fernandes LC, Kilicarslan T, Kaplan HL, Tyndale RF, Sellers EM, Romach MK. Treatment of codeine dependence with inhibitors of cytochrome P450 2D6. Journal of Clinical Psychopharmacology. 22: 326-9. PMID 12006904 DOI: 10.1097/00004714-200206000-00014  0.296
2017 Wells QS, Freiberg MS, Greevy RA, Tyndale RF, Kundu S, Duncan MS, King S, Scoville E, Beaulieu D, Gatskie V, Tindle HA. Nicotine Metabolism-informed Care for Smoking Cessation: A Pilot Precision RCT. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 29059367 DOI: 10.1093/Ntr/Ntx235  0.295
2020 Chukwueke CC, Kowalczyk WJ, Gendy M, Taylor R, Tyndale RF, Le Foll B, Heishman SJ. The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers. Brain and Behavior. e01982. PMID 33369277 DOI: 10.1002/brb3.1982  0.295
1997 Tyndale RF, Droll KP, Sellers EM. Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence. Pharmacogenetics. 7: 375-9. PMID 9352573 DOI: 10.1097/00008571-199710000-00006  0.294
2015 Tyndale RF, Zhu AZ, George TP, Cinciripini P, Hawk LW, Schnoll RA, Swan GE, Benowitz NL, Heitjan DF, Lerman C. Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking. Plos One. 10: e0128109. PMID 26010901 DOI: 10.1371/Journal.Pone.0128109  0.293
2016 Jukić MM, Opel N, Ström J, Carrillo-Roa T, Miksys S, Novalen M, Renblom A, Sim SC, Peñas-Lledó EM, Courtet P, Llerena A, Baune BT, de Quervain DJ, Papassotiropoulos A, Tyndale RF, et al. Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment. Molecular Psychiatry. PMID 27895323 DOI: 10.1038/Mp.2016.204  0.293
2023 Langlois AWR, El-Boraie A, Pouget JG, Cox LS, Ahluwalia JS, Fukunaga K, Mushiroda T, Knight J, Chenoweth MJ, Tyndale RF. Genotyping, characterization, and imputation of known and novel CYP2A6 structural variants using SNP array data. Journal of Human Genetics. PMID 37059825 DOI: 10.1038/s10038-023-01148-y  0.292
2021 Ho JTK, Tyndale RF, Baker TB, Amos CI, Chiu A, Smock N, Chen J, Bierut LJ, Chen LS. Racial disparities in intensity of smoke exposure and nicotine intake among low-dependence smokers. Drug and Alcohol Dependence. 221: 108641. PMID 33652379 DOI: 10.1016/j.drugalcdep.2021.108641  0.292
2013 Ogawa S, Surapisitchat J, Virtanen C, Ogawa M, Niapour M, Sugamori KS, Wang S, Tamblyn L, Guillemette C, Hoffmann E, Zhao B, Strom S, Laposa RR, Tyndale RF, Grant DM, et al. Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes. Development (Cambridge, England). 140: 3285-96. PMID 23861064 DOI: 10.1242/Dev.090266  0.29
2002 Pritzker D, Kanungo A, Kilicarslan T, Tyndale RF, Sellers EM. Designer drugs that are potent inhibitors of CYP2D6. Journal of Clinical Psychopharmacology. 22: 330-2. PMID 12006905 DOI: 10.1097/00004714-200206000-00015  0.289
2001 Gaedigk A, Casley WL, Tyndale RF, Sellers EM, Jurima-Romet M, Leeder JS. Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations. Canadian Journal of Physiology and Pharmacology. 79: 841-7. PMID 11697742 DOI: 10.1139/Y01-065  0.289
2021 Bien-Gund CH, Bilker W, Schnoll RA, Tyndale RF, Ho JI, Bremner R, Ashare RL, Gross R. Nicotine metabolism ratio increases in HIV-positive smokers on effective antiretroviral therapy: a cohort study. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 34879005 DOI: 10.1097/QAI.0000000000002880  0.289
2009 Bergen AW, Conti DV, Van Den Berg D, Lee W, Liu J, Li D, Guo N, Mi H, Thomas PD, Lessov-Schlaggar CN, Krasnow R, He Y, Nishita D, Jiang R, McClure JB, ... ... Tyndale RF, et al. Dopamine genes and nicotine dependence in treatment-seeking and community smokers. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2252-64. PMID 19494806 DOI: 10.1038/Npp.2009.52  0.289
2020 Jacobson MR, Watts JJ, Da Silva T, Tyndale RF, Rusjan PM, Houle S, Wilson AA, Ross RA, Boileau I, Mizrahi R. Fatty acid amide hydrolase is lower in young cannabis users. Addiction Biology. e12872. PMID 31960544 DOI: 10.1111/Adb.12872  0.289
2015 Boileau I, Tyndale RF, Williams B, Mansouri E, Westwood DJ, Foll BL, Rusjan PM, Mizrahi R, De Luca V, Zhou Q, Wilson AA, Houle S, Kish SJ, Tong J. The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [(11)C]CURB. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26036940 DOI: 10.1038/Jcbfm.2015.119  0.288
1999 SELLERS E, KAPLAN H, ROMACH M, TYNDALE R. Inhibition of CYP2A6 decreases smoking1 Clinical Pharmacology & Therapeutics. 65: 153-153. DOI: 10.1016/S0009-9236(99)80144-1  0.287
2012 Lee W, Bergen AW, Swan GE, Li D, Liu J, Thomas P, Tyndale RF, Benowitz NL, Lerman C, Conti DV. Gender-stratified gene and gene-treatment interactions in smoking cessation. The Pharmacogenomics Journal. 12: 521-32. PMID 21808284 DOI: 10.1038/Tpj.2011.30  0.286
2017 Taghavi T, Arger CA, Heil SH, Higgins ST, Tyndale RF. Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways. The Journal of Pharmacology and Experimental Therapeutics. PMID 29158210 DOI: 10.1124/Jpet.117.245126  0.285
2019 Ashare RL, Thompson M, Leone F, Metzger D, Gross R, Mounzer K, Tyndale RF, Lerman C, Mahoney MC, Cinciripini P, George TP, Collman RG, Schnoll R. Differences in the rate of nicotine metabolism among smokers with and without HIV. Aids (London, England). 33: 1083-1088. PMID 30946162 DOI: 10.1097/Qad.0000000000002127  0.285
2019 Ashare RL, Thompson M, Leone F, Metzger D, Gross R, Mounzer K, Tyndale RF, Lerman C, Mahoney MC, Cinciripini P, George TP, Collman RG, Schnoll R. Differences in the rate of nicotine metabolism among smokers with and without HIV. Aids (London, England). PMID 30649060 DOI: 10.1097/QAD.0000000000002127  0.285
2021 Chenoweth MJ, Cox LS, Nollen NL, Ahluwalia JS, Benowitz NL, Lerman C, Knight J, Tyndale RF. Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans. Scientific Reports. 11: 19572. PMID 34599228 DOI: 10.1038/s41598-021-98883-z  0.284
2016 Tanner JA, Prasad B, Claw KG, Stapleton P, Chaudhry A, Schuetz EG, Thummel KE, Tyndale RF. Predictors of variation in CYP2A6 mRNA, protein, and enzyme activity in a human liver bank: influence of genetic and non-genetic factors. The Journal of Pharmacology and Experimental Therapeutics. PMID 27815364 DOI: 10.1124/Jpet.116.237594  0.284
2007 Lee AM, Jepson C, Hoffmann E, Epstein L, Hawk LW, Lerman C, Tyndale RF. CYP2B6 genotype alters abstinence rates in a bupropion smoking cessation trial. Biological Psychiatry. 62: 635-41. PMID 17223085 DOI: 10.1016/J.Biopsych.2006.10.005  0.282
2021 Cunningham JA, Leatherdale ST, Chaiton M, Tyndale RF, Schell C, Godinho A. Offering nicotine patches to all households in a community with high smoking rates: Pilot test of a population-based approach to promote tobacco cessation. International Journal of Population Data Science. 6: 1400. PMID 34007899 DOI: 10.23889/ijpds.v6i1.1400  0.282
2015 Zhu AZ, Cox LS, Ahluwalia JS, Renner CC, Hatsukami DK, Benowitz NL, Tyndale RF. Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with BMI in males. Pharmacogenetics and Genomics. 25: 263-9. PMID 25794161 DOI: 10.1097/Fpc.0000000000000135  0.281
2013 Liu T, Tyndale RF, David SP, Wang H, Yu XQ, Chen W, Wen XZ, Chen WQ. Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers. Journal of Human Hypertension. 27: 24-30. PMID 22217675 DOI: 10.1038/jhh.2011.111  0.279
2019 Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S. Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults. British Journal of Clinical Pharmacology. PMID 30706508 DOI: 10.1111/bcp.13884  0.278
2018 Shahab L, Bauld L, McNeill A, Tyndale R. The impact of nicotine metabolite ratio on pharmacotherapy effectiveness in real-world settings: a longitudinal analysis Tobacco Induced Diseases. 16. DOI: 10.18332/tid/84540  0.277
2024 Jansen K, Tranby B, Shane A, Takeno T, Chadwick K, Sinicrope P, Shaw J, Tyndale R, Harris J, Patten C, Avey J. Implementing a Metabolism-Informed Approach for Smoking Cessation in an Alaska Tribal Health System: Study Protocol for a Single-Arm Implementation Pilot Trial. Research Square. PMID 38343834 DOI: 10.21203/rs.3.rs-3874126/v1  0.277
2020 El-Boraie A, Chenoweth MJ, Pouget JG, Benowitz NL, Fukunaga K, Mushiroda T, Kubo M, Nollen NL, Cox LS, Lerman C, Knight J, Tyndale RF. Transferability Of Ancestry-Specific And Cross-Ancestry CYP2A6 Activity Genetic Risk Scores In African And European Populations. Clinical Pharmacology and Therapeutics. PMID 33300144 DOI: 10.1002/cpt.2135  0.276
2001 Zhang W, Kilicarslan T, Tyndale RF, Sellers EM. Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 897-902. PMID 11353760  0.275
2008 Emamghoreishi M, Bokaee HR, Keshavarz M, Ghaderi A, Tyndale RF. CYP2A6 allele frequencies in an Iranian population. Archives of Iranian Medicine. 11: 613-7. PMID 18976031 DOI: 08116/AIM.007  0.274
2018 Best LM, Hendershot CS, Samantha J, Tong J, Le Foll B, Houle S, Tyndale RF, Bazinet R, Kish S, Boileau I. S265. Endocannabinoid Metabolism and Alcohol Consumption in Youth: A PET Study With the Fatty Acid Amide Hydrolase Radioligand [11C]CURB Biological Psychiatry. 83: S451. DOI: 10.1016/J.Biopsych.2018.02.1157  0.273
2022 Arens Y, Bilker WB, Han X, Plankey M, Ware D, Friedman MR, D'Souza G, Stosor V, Shoptaw S, Schnoll RA, Tyndale RF, Ashare R, Gross R. HIV Infection Does Not Explain Higher Nicotine Metabolism in People Living with HIV. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 36083509 DOI: 10.1097/QAI.0000000000003089  0.273
2017 McMillan DM, Tyndale RF. Inducing rat brain CYP2D with nicotine increases the rate of codeine tolerance; predicting the rate of tolerance from acute analgesic response. Biochemical Pharmacology. PMID 28837793 DOI: 10.1016/j.bcp.2017.08.015  0.271
2017 Peng AR, Le Foll B, Morales M, Lerman C, Schnoll R, Tyndale RF. Improvement of the association between self-reported pill count and varenicline levels following exclusion of participants with misreported pill count: A commentary on Peng et al. (2017). Addictive Behaviors. 79: 14-16. PMID 29232593 DOI: 10.1016/J.Addbeh.2017.11.032  0.271
2023 Giratallah H, Chenoweth MJ, Pouget JG, El-Boraie A, Alsaafin A, Lerman C, Knight J, Tyndale RF. CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian randomization study. Human Molecular Genetics. PMID 37802914 DOI: 10.1093/hmg/ddad172  0.27
2008 Christensen BK, Daskalakis J, Wong A, Tyndale R, Selby P, Laporte RD, Zipursky R. NICOTINE INDUCED INCREASES IN NEURAL INHIBITION AS A MECHANISM FOR ACUTE SYMPTOM ATTENUATION AMONG PATIENTS WITH SCHIZOPHRENIA Schizophrenia Research. 102: 135. DOI: 10.1016/S0920-9964(08)70409-2  0.27
2003 Gafni I, Busto UE, Tyndale RF, Kaplan HL, Sellers EM. The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo. Journal of Clinical Psychopharmacology. 23: 169-75. PMID 12640218 DOI: 10.1097/00004714-200304000-00009  0.27
2003 O'Loughlin J, DiFranza J, Tyndale RF, Meshefedjian G, McMillan-Davey E, Clarke PB, Hanley J, Paradis G. Nicotine-dependence symptoms are associated with smoking frequency in adolescents. American Journal of Preventive Medicine. 25: 219-25. PMID 14507528 DOI: 10.1016/S0749-3797(03)00198-3  0.27
2022 Stocco MR, Tyndale RF. Cytochrome P450 enzymes and metabolism of drugs and neurotoxins within the mammalian brain. Advances in Pharmacology (San Diego, Calif.). 95: 73-106. PMID 35953164 DOI: 10.1016/bs.apha.2022.04.003  0.27
2023 Avey JP, Schaefer KR, Noonan CJ, Trinidad SB, Muller CJ, Claw KG, Dillard DA, Todd MR, Beans JA, Tyndale RF, Robinson RF, Thummel KE. Identification of Sociodemographic, Clinical, and Genetic Factors to Aid Alaska Native and American Indian People to Successfully Quit Smoking. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 37527452 DOI: 10.1093/ntr/ntad133  0.269
2022 Giannoulis SV, Chenoweth MJ, Saquilayan P, Tyndale RF, Lerman C, Kennedy JL, Zawertailo L, Gonçalves V. Examining the role of mitochondrial genetic variation in nicotine dependence. Psychiatry Research. 310: 114452. PMID 35227992 DOI: 10.1016/j.psychres.2022.114452  0.269
2020 Kranzler HR, Washio Y, Zindel LR, Lynch KG, Hand D, Tyndale RF, Oncken C, Schnoll R. Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 32303761 DOI: 10.1093/ntr/ntaa066  0.269
2022 Carroll DM, Murphy S, Meier E, Rhodes K, Dorr C, Braaten G, Jacobson PA, Frizzell L, Tyndale RF, Hatsukami D, Hernandez C. Exploring potential for a personalized medicine approach to smoking cessation with an American Indian Tribe. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 35661899 DOI: 10.1093/ntr/ntac141  0.268
2016 Miksys S, Cheng N, Wadji FB, Tolledo E, Tyndale R. Haloperidol-induced catalepsy, a model of acute antipsychotic-induced extrapyramidal side effects, is altered by inhibiting and inducing CYP2D in rat brain European Neuropsychopharmacology. 26: S237-S238. DOI: 10.1016/S0924-977X(16)31102-6  0.267
1996 Ocampo J, Busto U, Kaplan H, Tyndale R, Otton S, Nolte H, Symanzik C, Sellers E. Does Extent of p-Hydroxylation Alter Methamphetamine Kinetics Clinical Pharmacology & Therapeutics. 59: 208-208. DOI: 10.1038/Sj.Clpt.1996.333  0.266
2015 Webb A, Papp AC, Curtis A, Newman LC, Pietrzak M, Seweryn M, Handelman SK, Rempala GA, Wang D, Graziosa E, Tyndale RF, Lerman C, Kelsoe JR, Mash DC, Sadee W. RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles. Bmc Genomics. 16: 990. PMID 26597164 DOI: 10.1186/S12864-015-2207-8  0.266
2021 Perez Diaz M, Pochon JB, Ghahremani DG, Dean AC, Faulkner P, Petersen N, Tyndale RF, Donis A, Paez D, Cahuantzi C, Hellemann GS, London ED. Sex Differences in the Association of Cigarette Craving with Insula Structure. The International Journal of Neuropsychopharmacology. PMID 33830218 DOI: 10.1093/ijnp/pyab015  0.265
2019 Frank DW, Cinciripini PM, Deweese MM, Karam-Hage M, Kypriotakis G, Lerman C, Robinson JD, Tyndale RF, Vidrine DJ, Versace F. Toward Precision Medicine for Smoking Cessation: Developing a Neuroimaging-Based Classification Algorithm to Identify Smokers at Higher Risk for Relapse. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31724052 DOI: 10.1093/Ntr/Ntz211  0.265
2011 Liu T, Chen WQ, David SP, Tyndale RF, Wang H, Chen YM, Yu XQ, Chen W, Zhou Q, Ling WH. Interaction between heavy smoking and CYP2A6 genotypes on type 2 diabetes and its possible pathways. European Journal of Endocrinology / European Federation of Endocrine Societies. 165: 961-7. PMID 21964962 DOI: 10.1530/Eje-11-0596  0.264
2024 Chenoweth MJ, Kim YJ, Nollen NL, Hawk LW, Mahoney MC, Lerman C, Knight J, Tyndale RF. Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome-Wide Investigation of Abnormal Dreams on Varenicline. Clinical Pharmacology and Therapeutics. PMID 38369951 DOI: 10.1002/cpt.3210  0.264
2014 Cascorbi I, Tyndale R. Progress in pharmacogenomics: Bridging the gap from research to practice Clinical Pharmacology and Therapeutics. 95: 231-235. PMID 24548984 DOI: 10.1038/Clpt.2013.235  0.262
2006 Lee AM, Joshi M, Yue J, Tyndale RF. Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism. European Journal of Pharmacology. 552: 151-8. PMID 17049344 DOI: 10.1016/j.ejphar.2006.09.006  0.26
2020 Kolla NJ, Mizrahi R, Karas K, Wang C, Bagby RM, McMain S, Simpson AI, Rusjan PM, Tyndale R, Houle S, Boileau I. Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [C]CURB positron emission tomography study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32521537 DOI: 10.1038/S41386-020-0731-Y  0.26
2023 O'Neill J, Diaz MP, Alger JR, Pochon JB, Ghahremani D, Dean AC, Tyndale RF, Petersen N, Marohnic S, Karaiskaki A, London ED. Smoking, tobacco dependence, and neurometabolites in the dorsal anterior cingulate cortex. Molecular Psychiatry. PMID 37749232 DOI: 10.1038/s41380-023-02247-0  0.26
2000 Davies PA, Hoffmann EB, Carlisle HJ, Tyndale RF, Hales TG. The influence of an endogenous beta3 subunit on recombinant GABA(A) receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells. Neuropharmacology. 39: 611-20. PMID 10728882 DOI: 10.1016/S0028-3908(99)00163-X  0.258
2019 Tolledo EC, Stocco M, Miksys S, Gonzales F, Wadji FB, Zhao B, Tyndale RF. A mouse model for investigating human brain CYP2D6 Drug Metabolism and Pharmacokinetics. 34: S15. DOI: 10.1016/J.Dmpk.2018.09.074  0.256
1998 Bronstein JM, Hales TG, Tyndale RF, Charles AC. A conditionally immortalized glial cell line that expresses mature myelin proteins and functional GABA(A) receptors. Journal of Neurochemistry. 70: 483-91. PMID 9453541 DOI: 10.1046/J.1471-4159.1998.70020483.X  0.256
2020 Gaudette E, Watling S, Warsh J, McCluskey T, Tong J, Houle S, Rusjan PM, Rhind SG, Bazinet R, Tyndale RF, Richardson JD, Hill MN, Jelty R, Kish S, Boileau I. Endocannabinoid Metabolism in Posttraumatic Stress Disorder: Results From a Neuroimaging Study With the Novel Fatty Acid Amide Hydrolase Probe, [C-11] Curb Biological Psychiatry. 87: S282-S283. DOI: 10.1016/J.Biopsych.2020.02.729  0.256
1999 Tyndale RF, Li Y, Li NY, Messina E, Miksys S, Sellers EM. Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 27: 924-30. PMID 10421620  0.255
2023 Ibrahim C, Tang VM, Blumberger DM, Malik S, Tyndale RF, Trevizol AP, Barr MS, Daskalakis ZJ, Zangen A, Le Foll B. Efficacy of insula deep repetitive transcranial magnetic stimulation combined with varenicline for smoking cessation: A randomized, double-blind, sham controlled trial. Brain Stimulation. 16: 1501-1509. PMID 37806524 DOI: 10.1016/j.brs.2023.10.002  0.255
2017 McMillan DM, Miksys S, Tyndale RF. Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia. Addiction Biology. PMID 29266563 DOI: 10.1111/adb.12590  0.254
2019 Robinson JD, Li L, Chen M, Lerman C, Tyndale RF, Schnoll RA, Hawk LW, George TP, Benowitz NL, Cinciripini PM. Evaluating the temporal relationships between withdrawal symptoms and smoking relapse. Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors. PMID 30614717 DOI: 10.1037/Adb0000434  0.253
2022 Richards J, Miksys S, Novalen M, Tyndale RF. CYP2D in the brain impacts oral hydrocodone analgesia in vivo. Neuropharmacology. 221: 109291. PMID 36241086 DOI: 10.1016/j.neuropharm.2022.109291  0.251
2014 Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, Gong L, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agundez JA, Freimuth RR, Huser V, Lee MT, Iwuchukwu OF, ... ... Tyndale RF, et al. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. Current Drug Metabolism. 15: 209-17. PMID 24479687 DOI: 10.2174/1389200215666140130124910  0.25
1998 Tyndale RF, Droll KP, Sellers EM. Relevance of deficient CYP2D6 in opiate dependence Pharmacogenetics. 8: 567. DOI: 10.1097/00008571-199812000-00015  0.25
2021 El-Boraie A, Tanner JA, Zhu AZX, Claw KG, Prasad B, Schuetz EG, Thummel KE, Fukunaga K, Mushiroda T, Kubo M, Benowitz NL, Lerman C, Tyndale RF. Functional Characterization Of Novel Rare CYP2A6 Variants And Potential Implications For Clinical Outcomes. Clinical and Translational Science. PMID 34476898 DOI: 10.1111/cts.13135  0.25
2020 Watts JJ, Jacobson MR, Lalang N, Boileau I, Tyndale RF, Kiang M, Ross RA, Houle S, Wilson AA, Rusjan P, Mizrahi R. Imaging Brain Fatty Acid Amide Hydrolase in Untreated Patients With Psychosis. Biological Psychiatry. PMID 32387132 DOI: 10.1016/J.Biopsych.2020.03.003  0.25
2001 Kilicarslan T, Haining RL, Rettie AE, Busto U, Tyndale RF, Sellers EM. Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 460-5. PMID 11259331  0.249
2019 Gupta R, van Dongen J, Fu Y, Abdellaoui A, Tyndale RF, Velagapudi V, Boomsma DI, Korhonen T, Kaprio J, Loukola A, Ollikainen M. Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci. Clinical Epigenetics. 11: 1. PMID 30611298 DOI: 10.1186/s13148-018-0606-9  0.249
2019 Milosavljević F, Vučić M, Manojlović M, Ašujić N, Batinić B, Novalen M, Miksys S, Tyndale R, Ingelman-Sundberg M, Pešić V, Jukić M. P.2.25 Transgenic mouse, carrier of human CYP2C19 gene, as an animal model for hyperdopaminergism-induced hyperkinesia European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2019.01.056  0.249
2017 Chen LS, Zawertailo L, Piasecki TM, Kaprio J, Foreman M, Elliott HR, David SP, Bergen AW, Baurley JW, Tyndale RF, Baker TB, Bierut LJ, Saccone NL. Leveraging genomic data in smoking cessation trials in the era of Precision Medicine: Why and how. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 28498934 DOI: 10.1093/Ntr/Ntx097  0.248
1997 Tomkins DM, Otton SV, Joharchi N, Li NY, Balster RF, Tyndale RF, Sellers EM. Effect of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats. The Journal of Pharmacology and Experimental Therapeutics. 280: 1374-82. PMID 9067326  0.248
2019 Mansouri E, Tyndale RF, Hendershot CS, Best LM, Di Ciano P, Hill M, Nobrega JJ, Sloan M, Kish S, Tong J, Le Foll B, Boileau I. S203. Fatty Acid Amide Hydrolase Polymorphism C385A Associated With Dopamine D2/3 Receptor Levels: A PET Study With [11C]-(+)-PHNO Biological Psychiatry. 85: S376. DOI: 10.1016/J.Biopsych.2019.03.954  0.248
2003 Tyndale RF. Genetics of alcohol and tobacco use in humans. Annals of Medicine. 35: 94-121. PMID 12795339 DOI: 10.1080/07853890310010014  0.248
2008 Mwenifumbo JC, Sellers EM, Tyndale RF. Socioeconomic and drug use determinants of smoking status in an urban adult population of Black African descent. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 10: 1319-25. PMID 18686179 DOI: 10.1080/14622200802238894  0.247
2017 McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, ... ... Tyndale RF, et al. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nature Genetics. PMID 28604730 DOI: 10.1038/Ng.3892  0.246
2022 Alsaafin A, Chenoweth MJ, Sylvestre MP, O'Loughlin J, Tyndale RF. Genetic variation in fatty acid amide hydrolase (FAAH): Associations with early drinking and smoking behaviors. Addictive Behaviors. 137: 107545. PMID 36403489 DOI: 10.1016/j.addbeh.2022.107545  0.245
2014 Garcia KL, Lê AD, Tyndale RF. Effect of food training and training dose on nicotine self-administration in rats. Behavioural Brain Research. 274: 10-8. PMID 25101539 DOI: 10.1016/j.bbr.2014.07.043  0.245
2018 Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian D, Joubert P, Lamontagne M, Li Y, Gorlov I, de Biasi M, Han Y, Gorlova O, Hung RJ, Wu X, ... ... Tyndale RF, et al. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nature Communications. 9: 3221. PMID 30104567 DOI: 10.1038/S41467-018-05074-Y  0.245
2021 Ghahremani DG, Pochon JB, Perez Diaz M, Tyndale RF, Dean AC, London ED. Functional connectivity of the anterior insula during withdrawal from cigarette smoking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34035468 DOI: 10.1038/s41386-021-01036-z  0.244
2021 Wang J, Conti DV, Epeldegui M, Ollikainen M, Tyndale RF, Hwang AE, Magpantay L, Mack TM, Martinez-Maza O, Kaprio J, Cozen W. Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking. Cancers. 13. PMID 34771561 DOI: 10.3390/cancers13215395  0.243
2004 Miksys S, Tyndale RF. The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics. Drug Metabolism Reviews. 36: 313-33. PMID 15237857 DOI: 10.1081/DMR-120034149  0.243
2017 Miksys S, Wadji FB, Tolledo EC, Remington G, Nobrega JN, Tyndale RF. Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 28454738 DOI: 10.1016/J.Pnpbp.2017.04.030  0.242
2019 Daskalakis ZJ, Tyndale RF. A Physiological Marriage Made in Heaven: Treating and Measuring the Brain Through Stimulation. Clinical Pharmacology and Therapeutics. 106: 691-695. PMID 31509631 DOI: 10.1002/Cpt.1576  0.242
2008 Tyndale R. Drug addiction: a critical problem calling for novel solutions. Clinical Pharmacology and Therapeutics. 83: 503-6. PMID 18349865 DOI: 10.1038/Clpt.2008.11  0.241
1997 Cheung S, Nolte H, Otton SV, Tyndale RF, Wu PH, Sellers EM. Simultaneous gas chromatographic determination of methamphetamine, amphetamine and their p-hydroxylated metabolites in plasma and urine. Journal of Chromatography. B, Biomedical Sciences and Applications. 690: 77-87. PMID 9106031 DOI: 10.1016/S0378-4347(96)00361-1  0.24
2021 Chenoweth MJ, Peng AR, Zhu AZX, Cox LS, Nollen NL, Ahluwalia JS, Benowitz NL, Knight J, Swardfager W, Tyndale RF. Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration, and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis. Addiction (Abingdon, England). PMID 34791718 DOI: 10.1111/add.15742  0.24
2023 Siegel SD, Tindle HA, Bergen AW, Tyndale RF, Schnoll R. The use of biomarkers to guide precision treatment for tobacco use. Addiction Neuroscience. 6. PMID 37089247 DOI: 10.1016/j.addicn.2023.100076  0.239
2022 Cox LS, Nollen NL, Mayo MS, Faseru B, Greiner A, Ellerbeck EF, Krebill R, Tyndale RF, Benowitz NL, Ahluwalia JS. Effect of Varenicline Added to Counseling on Smoking Cessation Among African American Daily Smokers: The Kick It at Swope IV Randomized Clinical Trial. Jama. 327: 2201-2209. PMID 35699705 DOI: 10.1001/jama.2022.8274  0.238
2022 Hawk LW, Tiffany ST, Colder CR, Ashare RL, Wray JM, Tyndale RF, Brandon TH, Mahoney MC. Effect of Extending the Duration of Prequit Treatment With Varenicline on Smoking Abstinence: A Randomized Clinical Trial. Jama Network Open. 5: e2241731. PMID 36367720 DOI: 10.1001/jamanetworkopen.2022.41731  0.238
2021 Chenoweth MJ, Lerman C, Knight J, Tyndale RF. A genome-wide association study of nausea incidence in varenicline-treated cigarette smokers. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 33713409 DOI: 10.1093/ntr/ntab044  0.237
1991 Tyndale RF, Sunahara R, Inaba T, Kalow W, Gonzalez FJ, Niznik HB. Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. Molecular Pharmacology. 40: 63-8. PMID 1857341  0.237
2007 Tyndale RF, Payne JI, Gerber AL, Sipe JC. The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 660-6. PMID 17290447 DOI: 10.1002/ajmg.b.30491  0.234
2017 Kozak K, Dermody SS, Rabin RA, Zack M, Barr MS, Tyndale RF, George TP. Effects of varenicline on cognitive function in non-smokers with schizophrenia. Schizophrenia Research. PMID 28291692 DOI: 10.1016/J.Schres.2017.03.023  0.234
1997 Nowak MP, Tyndale RF, Sellers EM. CYP2D6 phenotype and genotype in a Canadian Native Indian population. Pharmacogenetics. 7: 145-8. PMID 9170152 DOI: 10.1097/00008571-199704000-00008  0.234
2022 McColl ER, Kwok J, Benowitz NL, Patten CA, Hughes CA, Koller KR, Flanagan CA, Thomas TK, Hiratsuka VY, Tyndale RF, Piquette-Miller M. The effect of tobacco use on the expression of placental transporters in Alaska Native women. Clinical Pharmacology and Therapeutics. PMID 36053152 DOI: 10.1002/cpt.2737  0.233
2020 El-Sherbeni AA, Stocco MR, Wadji FB, Tyndale RF. Addressing the instability issue of dopamine during microdialysis: the determination of dopamine, serotonin, methamphetamine and its metabolites in rat brain. Journal of Chromatography. A. 1627: 461403. PMID 32823108 DOI: 10.1016/J.Chroma.2020.461403  0.232
2004 McKeown-Eyssen G, Baines C, Cole DE, Riley N, Tyndale RF, Marshall L, Jazmaji V. Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR. International Journal of Epidemiology. 33: 971-8. PMID 15256524 DOI: 10.1093/Ije/Dyh251  0.232
2020 Hasbi A, Nguyen T, Rahal H, Manduca JD, Miksys S, Tyndale RF, Madras BK, Perreault ML, George SR. Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors. Biology of Sex Differences. 11: 8. PMID 32087746 DOI: 10.1186/S13293-020-00285-9  0.231
2014 O'Loughlin J, Dugas EN, Brunet J, DiFranza J, Engert JC, Gervais A, Gray-Donald K, Karp I, Low NC, Sabiston C, Sylvestre MP, Tyndale RF, Auger N, Auger N, Mathieu B, et al. Cohort Profile: The Nicotine Dependence in Teens (NDIT) Study. International Journal of Epidemiology. PMID 25022274 DOI: 10.1093/Ije/Dyu135  0.231
2003 Miksys S, Lerman C, Shields P, Mash D, Tyndale R. The influence of smoking, alcoholism and genetics on CYP2B6 in human brain Clinical Pharmacology & Therapeutics. 73: P59-P59. DOI: 10.1016/S0009-9236(03)90576-5  0.231
2018 Bierut LJ, Tyndale RF. Preparing the Way: Exploiting Genomic Medicine to Stop Smoking. Trends in Molecular Medicine. PMID 29307500 DOI: 10.1016/j.molmed.2017.12.001  0.23
2015 Kalman LV, Agúndez JA, Appell ML, Black JL, Bell GC, Boukouvala S, Bruckner C, Bruford E, Bruckner C, Caudle K, Coulthard S, Daly AK, Del Tredici AL, den Dunnen JT, Drozda K, ... ... Tyndale R, et al. Pharmacogenetic Allele Nomenclature: International Workgroup Recommendations for Test Result Reporting. Clinical Pharmacology and Therapeutics. PMID 26479518 DOI: 10.1002/Cpt.280  0.229
2018 Mansouri E, Best LM, Le Foll B, Hendershot CS, Tyndale RF, Kish S, Tong J, Boileau I. T76. Involvement of the Endocannabinoid Enzyme Fatty Acid Amide Hydrolase in the Neurobiology of Impulsivity: Positron Emission Tomography Studies With [11C]CURB Biological Psychiatry. 83: S158. DOI: 10.1016/J.Biopsych.2018.02.412  0.225
2021 Stocco MR, El-Sherbeni AA, Zhao B, Novalen M, Tyndale RF. The role of CYP2D in rat brain in methamphetamine-induced striatal dopamine and serotonin release and behavioral sensitization. Psychopharmacology. PMID 33649968 DOI: 10.1007/s00213-021-05808-9  0.225
1998 Droll K, Bruce-Mensah K, Otton SV, Gaedigk A, Sellers EM, Tyndale RF. Comparison of three CYP2D6 probe substrates and genotype in Ghanaians, Chinese and Caucasians. Pharmacogenetics. 8: 325-33. PMID 9731719  0.224
2011 Rehm J, Giesbrecht N, Gliksman L, Graham K, Le AD, Mann RE, Room R, Rush B, Tyndale RF, Wells S. Addiction Research Centres and the Nurturing of Creativity. Substance abuse research in a modern health care centre: the case of the Centre for Addiction and Mental Health. Addiction (Abingdon, England). 106: 689-97. PMID 20491727 DOI: 10.1111/J.1360-0443.2010.02955.X  0.223
2022 Tonkin SS, Colder C, Mahoney MC, Swan GE, Cinciripini P, Schnoll R, George TP, Tyndale RF, Hawk LW. Evaluating Treatment Mechanisms of Varenicline: Mediation by Affect and Craving. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 35639828 DOI: 10.1093/ntr/ntac138  0.222
1995 Tyndale R, Sellers E, Li N. The Brain as a Drug Metabolizing Organ: Genetic Variability in CNS Opiate Metabolism. Analgesia. 1: 789-792. DOI: 10.3727/107156995819562943  0.221
2002 Xu C, Rao YS, Xu B, Hoffmann E, Jones J, Sellers EM, Tyndale RF. An in vivo pilot study characterizing the new CYP2A6*7, *8, and *10 alleles. Biochemical and Biophysical Research Communications. 290: 318-24. PMID 11779172 DOI: 10.1006/Bbrc.2001.6209  0.22
2022 Alsaafin A, Chenoweth MJ, Sylvestre MP, O'Loughlin J, Tyndale RF. Does genetic variation in a bitter taste receptor gene alter early smoking behaviours in adolescents and young adults? Addiction (Abingdon, England). PMID 35293057 DOI: 10.1111/add.15871  0.22
2019 Senft N, Sanderson M, Selove R, Blot WJ, King S, Gilliam K, Kundu S, Steinwandel M, Sternlieb SJ, Warren Andersen S, Friedman DL, Connors E, Fadden MK, Freiberg M, Wells QS, ... ... Tyndale RF, et al. Attitudes towards precision treatment of smoking in the Southern Community Cohort Study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 31160346 DOI: 10.1158/1055-9965.EPI-19-0179  0.219
2016 Jukić M, Opel N, Ström J, Carrillo-Roa T, Miksys S, Novalen M, Renblom A, Sim S, Peñas-Lledó E, Courtet P, Llerena A, Papassotiropoulos A, Tyndale R, Binder E, Dannlowski U, et al. CYP2C19 expression is associated with depressive symptoms and hippocampal serotonin homeostasis impairment European Neuropsychopharmacology. 26. DOI: 10.1016/S0924-977X(16)31328-1  0.217
2019 Stevens EM, Frank D, Codispoti M, Kypriotakis G, Cinciripini PM, Claiborne K, Deweese MM, Engelmann JM, Green CE, Karam-Hage M, Minnix JA, Ng J, Robinson JD, Tyndale RF, Vidrine DJ, et al. The Late Positive Potentials Evoked by Cigarette-Related and Emotional Images Show no Gender Differences in Smokers. Scientific Reports. 9: 3240. PMID 30824792 DOI: 10.1038/S41598-019-39954-0  0.215
2006 Karp I, O'Loughlin J, Hanley J, Tyndale RF, Paradis G. Risk factors for tobacco dependence in adolescent smokers. Tobacco Control. 15: 199-204. PMID 16728750 DOI: 10.1136/tc.2005.014118  0.213
1998 Nowak MP, Sellers EM, Tyndale RF. Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies. Clinical Pharmacology and Therapeutics. 64: 378-83. PMID 9797794 DOI: 10.1016/S0009-9236(98)90068-6  0.211
2021 Desta Z, El-Boraie A, Gong L, Somogyi AA, Lauschke VM, Dandara C, Klein K, Miller N, Klein TE, Tyndale RF, Whirl-Carrillo M, Gaedigk A. PharmVar GeneFocus: CYP2B6. Clinical Pharmacology and Therapeutics. PMID 33448339 DOI: 10.1002/cpt.2166  0.211
2002 Miksys SL, Tyndale RF. Drug-metabolizing cytochrome P450s in the brain. Journal of Psychiatry & Neuroscience : Jpn. 27: 406-15. PMID 12491573  0.211
2011 Desta Z, Kreutz Y, Nguyen AT, Li L, Skaar T, Kamdem LK, Henry NL, Hayes DF, Storniolo AM, Stearns V, Hoffmann E, Tyndale RF, Flockhart DA. Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age. Clinical Pharmacology and Therapeutics. 90: 693-700. PMID 21975350 DOI: 10.1038/clpt.2011.174  0.209
2021 Coleman SRM, Bunn JY, Nighbor TD, Kurti AN, Bolívar HA, Tyndale RF, Higgins ST. Use of electronic nicotine delivery systems (ENDS) among U.S. women of reproductive age: Prevalence, reported reasons for use, and toxin exposure. Preventive Medicine. 106582. PMID 33930436 DOI: 10.1016/j.ypmed.2021.106582  0.208
2020 Ahmed M, Tyndale RF, Rubin-Kahana DS, Le Foll B, Daskalakis ZJ, Boileau I, Kloiber S. Investigating Fatty Acid Amide Hydrolase Levels in Social Anxiety Disorder: A Positron Emission Tomography (PET) Study Using [C-11]CURB Biological Psychiatry. 87: S299. DOI: 10.1016/J.Biopsych.2020.02.770  0.207
2014 Bergen AW, Javitz HS, Krasnow R, Michel M, Nishita D, Conti DV, Edlund CK, Kwok PY, McClure JB, Kim RB, Hall SM, Tyndale RF, Baker TB, Benowitz NL, Swan GE. Organic cation transporter variation and response to smoking cessation therapies. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 16: 1638-46. PMID 25143296 DOI: 10.1093/Ntr/Ntu161  0.205
2017 Peng AR, Morales M, Wileyto EP, Hawk LW, Cinciripini P, George TP, Benowitz NL, Nollen NL, Lerman C, Tyndale RF, Schnoll R. Measures and predictors of varenicline adherence in the treatment of nicotine dependence. Addictive Behaviors. 75: 122-129. PMID 28728040 DOI: 10.1016/J.Addbeh.2017.07.006  0.204
2013 Dempsey DA, Sambol NC, Jacob P, Hoffmann E, Tyndale RF, Fuentes-Afflick E, Benowitz NL. CYP2A6 genotype but not age determines cotinine half-life in infants and children. Clinical Pharmacology and Therapeutics. 94: 400-6. PMID 23714690 DOI: 10.1038/clpt.2013.114  0.204
2018 Boileau I, Westwood D, Richardson D, Rhind S, Tyndale RF, Lanius R, Bazinet R, Lobaugh NJ, Houle S. 51. Investigating Endocannabinoid Mechanisms in Posttraumatic Stress Disorder: Neuroimaging Studies With the Novel Fatty Acid Amide Hydrolase Probe, [11C]CURB Biological Psychiatry. 83: S21. DOI: 10.1016/J.Biopsych.2018.02.068  0.203
2011 Wells S, Flynn A, Graham K, Rehm J, Cairney J, Kates N, Kennedy JL, Lobo DS, Chaiton M, Menzies P, Tyndale RF, Verjee Z. Using a Mobile Laboratory to Study Mental Health, Addictions and Violence: A Research Plan Challenges. 2: 1-18. DOI: 10.3390/Challe2010001  0.203
1990 Tyndale RF, Inaba T. Simultaneous determination of haloperidol and reduced haloperidol by gas chromatography using a megabore column with electron-capture detection: application to microsomal oxidation of reduced haloperidol. Journal of Chromatography. 529: 182-8. PMID 2211930 DOI: 10.1016/S0378-4347(00)83820-7  0.201
2015 Wassenaar CA, Ye Y, Cai Q, Aldrich MC, Knight J, Spitz MR, Wu X, Blot WJ, Tyndale RF. CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations. Carcinogenesis. 36: 99-103. PMID 25416559 DOI: 10.1093/Carcin/Bgu235  0.2
2023 Truong VTT, Green C, Pedroza C, Hwang LY, Rajan SS, Suchting R, Cinciripini P, Tyndale RF, Lerman C. Bayesian regularization to predict neuropsychiatric adverse events in smoking cessation with pharmacotherapy. Bmc Medical Research Methodology. 23: 107. PMID 37118656 DOI: 10.1186/s12874-023-01931-7  0.2
2021 Novalen M, Chenoweth MJ, Zhao B, Hawk LW, Tyndale RF. Stability of varenicline concentration in saliva over twenty-one days at three storage temperatures. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 34460924 DOI: 10.1093/ntr/ntab173  0.197
2022 Arguelles N, Richards J, El-Sherbeni AA, Miksys S, Tyndale RF. Sex, estrous cycle, and hormone regulation of CYP2D in the brain alters oxycodone metabolism and analgesia. Biochemical Pharmacology. 198: 114949. PMID 35143755 DOI: 10.1016/j.bcp.2022.114949  0.195
2020 Green D, Kim J, Kish S, Tyndale RF, Hill M, Strafella A, Tong J, McCluskey T, Westwood D, Houle S, Lobaugh NJ, Boileau I. Fatty Acid Amide Hydrolase and Threat Related Amygdala Activity: A Combined Positron Emission Tomography and Magnetic Resonance Imaging Study Biological Psychiatry. 87: S173-S174. DOI: 10.1016/J.Biopsych.2020.02.458  0.195
2002 Miksys S, Rao Y, Hoffmann E, Mash DC, Tyndale RF. Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics. Journal of Neurochemistry. 82: 1376-87. PMID 12354285 DOI: 10.1046/J.1471-4159.2002.01069.X  0.193
2018 Tyndale RF, Sellers EM. Opioids: The Painful Public Health Reality. Clinical Pharmacology and Therapeutics. 103: 924-935. PMID 29878319 DOI: 10.1002/Cpt.1074  0.192
1996 Charles AC, Kodali SK, Tyndale RF. Intercellular calcium waves in neurons. Molecular and Cellular Neurosciences. 7: 337-53. PMID 8812061 DOI: 10.1006/Mcne.1996.0025  0.191
2002 O'Loughlin J, DiFranza J, Tarasuk J, Meshefedjian G, McMillan-Davey E, Paradis G, Tyndale RF, Clarke P, Hanley J. Assessment of nicotine dependence symptoms in adolescents: a comparison of five indicators. Tobacco Control. 11: 354-60. PMID 12432161  0.188
2021 Boronat A, Rodriguez-Morató J, Serreli G, Fitó M, Tyndale RF, Deiana M, de la Torre R. Contribution of Biotransformations Carried Out by the Microbiota, Drug-Metabolizing Enzymes, and Transport Proteins to the Biological Activities of Phytochemicals Found in the Diet. Advances in Nutrition (Bethesda, Md.). PMID 34388248 DOI: 10.1093/advances/nmab085  0.185
2007 Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, ... ... Tyndale RF, et al. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clinical Pharmacology and Therapeutics. 81: 328-45. PMID 17339863 DOI: 10.1038/Sj.Clpt.6100087  0.185
2016 Wang LA, Gonzalez D, Leeder JS, Tyndale RF, Pearce RE, Benjamin DK, Kearns GL, Cohen-Wolkowiez M. Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation. Journal of Clinical Pharmacology. PMID 27417511 DOI: 10.1002/jcph.797  0.184
2016 Tyndale R, Miksys S. CYP2D activity in the brain acts independently from CYP2D in the liver to alter CNS drug levels and response European Neuropsychopharmacology. 26: S119. DOI: 10.1016/S0924-977X(16)30885-9  0.183
2013 Cheng J, Zhen Y, Miksys S, BeyoÄŸlu D, Krausz KW, Tyndale RF, Yu A, Idle JR, Gonzalez FJ. Potential role of CYP2D6 in the central nervous system. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 973-84. PMID 23614566 DOI: 10.3109/00498254.2013.791410  0.181
2019 Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF. Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities. Clinical Pharmacology and Therapeutics. PMID 31696505 DOI: 10.1002/Cpt.1664  0.178
2021 Arguelles N, Miksys S, Tyndale RF. Sex and Estrous Cycle Differences in Analgesia and Brain Oxycodone Levels. Molecular Neurobiology. 58: 6540-6551. PMID 34581987 DOI: 10.1007/s12035-021-02560-1  0.173
2010 Mroziewicz M, Tyndale RF. Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment. Addiction Science & Clinical Practice. 5: 17-29. PMID 22002450  0.17
2022 Senft Everson N, Klein WMP, Lee SS, Selove R, Sanderson M, Blot WJ, Tyndale RF, King S, Gilliam K, Kundu S, Steinwandel M, Sternlieb SJ, Warren Andersen S, Friedman DL, Connors E, et al. Dispositional optimism and optimistic bias: Associations with cessation motivation, confidence, and attitudes. Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association. PMID 35901400 DOI: 10.1037/hea0001184  0.168
2013 Bergen AW, Javitz HS, Su L, He Y, Conti DV, Benowitz NL, Tyndale RF, Lerman C, Swan GE. The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 15: 1190-200. PMID 23212438 DOI: 10.1093/Ntr/Nts245  0.167
2000 Mash DC, Kovera CA, Pablo J, Tyndale RF, Ervin FD, Williams IC, Singleton EG, Mayor M. Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures. Annals of the New York Academy of Sciences. 914: 394-401. PMID 11085338 DOI: 10.1111/J.1749-6632.2000.Tb05213.X  0.16
2019 Tolledo EC, Miksys S, Gonzalez FJ, Tyndale RF. Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: effects on activity and drug response. British Journal of Pharmacology. PMID 31648367 DOI: 10.1111/bph.14884  0.156
2008 Grant DM, Tyndale RF. In memoriam: Werner Kalow, MD (1917–2008) Pharmacogenetics and Genomics. 18: 835-836. DOI: 10.1097/Fpc.0B013E32830D102D  0.154
1992 Otton SV, Tyndale RF, Wu D, Inaba T, Kalow W, Sellers EM. Catalytic and immunologic similarities between monkey and human liver cytochrome P-450db1 (human cytochrome P-450 2D6). Drug Metabolism and Disposition: the Biological Fate of Chemicals. 20: 1-5. PMID 1346982  0.153
1997 Sellers EM, Otton SV, Tyndale RF. The potential role of the cytochrome P-450 2D6 pharmacogenetic polymorphism in drug abuse. Nida Research Monograph. 173: 6-26. PMID 9260180  0.152
1999 Tyndale RF, Tomkins DM. Differences in propensity for drinking alcohol are reflected in subunit- and region-specific GABA(A) receptor levels. Addiction Biology. 4: 309-16. PMID 20575797 DOI: 10.1080/13556219971515  0.151
2022 Watts JJ, Guma E, Chavez S, Tyndale RF, Ross RA, Houle S, Wilson AA, Chakravarty M, Rusjan PM, Mizrahi R. In vivo brain endocannabinoid metabolism is related to hippocampus glutamate and structure - a multimodal imaging study with PET, H-MRS, and MRI. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 35906490 DOI: 10.1038/s41386-022-01384-4  0.151
1998 Gaedigk A, Tyndale RF, Jurima-Romet M, Sellers EM, Grant DM, Leeder JS. NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations. Pharmacogenetics. 8: 305-13. PMID 9731717  0.147
2016 Avey JP, Hiratsuka VY, Beans JA, Trinidad SB, Tyndale RF, Robinson RF. Perceptions of pharmacogenetic research to guide tobacco cessation by patients, providers and leaders in a tribal healthcare setting. Pharmacogenomics. PMID 26871371 DOI: 10.2217/pgs.15.177  0.146
2016 Boileau I, Mansouri E, Williams B, Le Foll B, Rusjan P, Mizrahi R, Tyndale RF, Huestis MA, Payer DE, Wilson AA, Houle S, Kish SJ, Tong J. Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [(11)C]CURB. Biological Psychiatry. PMID 27345297 DOI: 10.1016/J.Biopsych.2016.04.012  0.143
2017 Rodríguez-Morató J, Robledo P, Tanner JA, Boronat A, Pérez-Mañá C, Oliver Chen CY, Tyndale RF, de la Torre R. CYP2D6 and CYP2A6 biotransform dietary tyrosol into hydroxytyrosol. Food Chemistry. 217: 716-25. PMID 27664690 DOI: 10.1016/j.foodchem.2016.09.026  0.141
2021 Best LM, Wardell JD, Tyndale RF, McPhee MD, Le Foll B, Kish SJ, Boileau I, Hendershot CS. Association of the Fatty Acid Amide Hydrolase C385A Polymorphism with Alcohol Use Severity and Coping Motives in Heavy-drinking Youth. Alcoholism, Clinical and Experimental Research. PMID 33460184 DOI: 10.1111/acer.14552  0.138
2023 Langlois AWR, Pouget JG, Knight J, Chenoweth MJ, Tyndale RF. Associating CYP2A6 structural variants with ovarian and lung cancer risk in the UK Biobank: replication and extension. European Journal of Human Genetics : Ejhg. PMID 38097766 DOI: 10.1038/s41431-023-01518-2  0.135
2017 Huestis MA, Tyndale RF. Designer Drugs 2.0. Clinical Pharmacology and Therapeutics. 101: 152-157. PMID 28084644 DOI: 10.1002/Cpt.575  0.132
2015 Le Foll B, Tyndale RF. Cannabinoids: Friend or foe? Clinical Pharmacology and Therapeutics. 97: 528-31. PMID 25801347 DOI: 10.1002/cpt.119  0.131
2013 Ting-A-Kee R, Vargas-Perez H, Bufalino MR, Bahi A, Dreyer JL, Tyndale RF, van der Kooy D. Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation. The European Journal of Neuroscience. 37: 996-1003. PMID 23279128 DOI: 10.1111/Ejn.12105  0.13
2013 Falcone M, Smith RM, Chenoweth MJ, Bhattacharjee AK, Kelsoe JR, Tyndale RF, Lerman C. Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2327-37. PMID 23793356 DOI: 10.1038/Npp.2013.152  0.13
2023 Kazi I, Chenoweth MJ, Jutras-Aswad D, Ahamad K, Socias ME, Le Foll B, Tyndale RF. Pharmacogenetics of Biochemically Verified Abstinence in an Opioid Agonist Therapy Randomized Clinical Trial of Methadone and Buprenorphine/Naloxone. Clinical Pharmacology and Therapeutics. PMID 38009933 DOI: 10.1002/cpt.3112  0.128
2016 Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Clinical Pharmacology and Therapeutics. PMID 27256705 DOI: 10.1002/Cpt.405  0.127
2019 Desta Z, Gammal RS, Gong L, Whirl-Carrillo M, Gaur AH, Sukasem C, Hockings J, Myers A, Swart M, Tyndale R, Masimirembwa C, Iwuchukwu OF, Chirwa S, Lennox J, Gaedigk A, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-containing Antiretroviral Therapy. Clinical Pharmacology and Therapeutics. PMID 31006110 DOI: 10.1002/cpt.1477  0.126
2020 Ashare RL, Wileyto EP, Logue-Chamberlain E, Gross R, Tyndale RF, Lerman C, Hawk LW, Cinciripini P, George TP, Lubitz SF, Schnoll R. Patterns of lapses and recoveries during a quit attempt using varenicline and behavioral counseling among smokers with and without HIV. Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors. PMID 32686950 DOI: 10.1037/Adb0000619  0.125
2022 Langlois AWR, El-Boraie A, Fukunaga K, Mushiroda T, Kubo M, Lerman C, Knight J, Scherer SE, Chenoweth MJ, Tyndale RF. Accuracy and applications of sequencing and genotyping approaches for CYP2A6 and homologous genes. Pharmacogenetics and Genomics. PMID 35190513 DOI: 10.1097/FPC.0000000000000466  0.123
2022 Milosavljević F, Brusini I, Atanasov A, Manojlović M, Vučić M, Oreščanin-Dušić Z, Brkljačić J, Miljević Č, Nikolić-Kokić A, Blagojević D, Wang C, Damberg P, Pešić V, Tyndale RF, Ingelman-Sundberg M, et al. The humanized CYP2C19 transgenic mouse exhibits cerebellar atrophy and movement impairment reminiscent of ataxia. Neuropathology and Applied Neurobiology. e12867. PMID 36536486 DOI: 10.1111/nan.12867  0.118
2023 Green DG, Westwood DJ, Kim J, Best LM, Kish SJ, Tyndale RF, McCluskey T, Lobaugh NJ, Boileau I. Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation. Neuroimage. Reports. 2: 100094. PMID 37235067 DOI: 10.1016/j.ynirp.2022.100094  0.116
2002 Zhang W, Ramamoorthy Y, Kilicarslan T, Nolte H, Tyndale RF, Sellers EM. Inhibition of cytochromes P450 by antifungal imidazole derivatives. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 314-8. PMID 11854151 DOI: 10.1124/Dmd.30.3.314  0.113
2000 Vandenbergh DJ, Thompson MD, Cook EH, Bendahhou E, Nguyen T, Krasowski MD, Zarrabian D, Comings D, Sellers EM, Tyndale RF, George SR, O'Dowd BF, Uhl GR. Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Molecular Psychiatry. 5: 283-92. PMID 10889531 DOI: 10.1038/Sj.Mp.4000701  0.112
2009 Miksys SL, Tyndale RF. Brain and disease: the long path to discovery and treatment. Clinical Pharmacology and Therapeutics. 86: 343-6. PMID 19763109 DOI: 10.1038/clpt.2009.168  0.11
2019 Boronat A, Mateus J, Soldevila-Domenech N, Guerra M, Rodríguez-Morató J, Varon C, Muñoz D, Barbosa F, Morales JC, Gaedigk A, Langohr K, Covas MI, Pérez-Mañá C, Fitó M, Tyndale RF, et al. Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial. Free Radical Biology & Medicine. 143: 471-481. PMID 31479717 DOI: 10.1016/j.freeradbiomed.2019.08.032  0.109
1994 Hales TG, Tyndale RF. Few cell lines with GABAA mRNAs have functional receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5429-36. PMID 8083746  0.105
1994 Hales T, Tyndale R. Few cell lines with GABAA mRNAs have functional receptors The Journal of Neuroscience. 14: 5429-5436. DOI: 10.1523/Jneurosci.14-09-05429.1994  0.105
2023 Coelho SG, Hendershot CS, Aston ER, Ruocco AC, Quilty LC, Tyndale RF, Wardell JD. Executive functions and behavioral economic demand for cannabis among young adults: Indirect associations with cannabis consumption and cannabis use disorder. Experimental and Clinical Psychopharmacology. PMID 37732960 DOI: 10.1037/pha0000678  0.102
2022 Best LM, Hendershot CS, Buckman JF, Jagasar S, McPhee MD, Muzumdar N, Tyndale RF, Houle S, Logan R, Sanches M, Kish SJ, Le Foll B, Boileau I. Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [C]CURB in Heavy-Drinking Youth. Biological Psychiatry. PMID 36868890 DOI: 10.1016/j.biopsych.2022.11.022  0.101
1995 Beischlag TV, Marchese A, Meador-Woodruff JH, Damask SP, O'Dowd BF, Tyndale RF, van Tol HH, Seeman P, Niznik HB. The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region. Biochemistry. 34: 5960-70. PMID 7727453  0.1
1996 Grudzinskas CV, Woosley RL, Payte TJ, Collins J, Moody DE, Tyndale RF, Sellers EM. The documented role of pharmacogenetic: in the identification and administration of new medications for treating drug abuse. Nida Research Monograph. 162: 60-3. PMID 9066815  0.096
2019 Boronat A, Mateus J, Soldevila-Domenech N, Guerra M, Rodríguez-Morató J, Varon C, Muñoz D, Barbosa F, Morales JC, Gaedigk A, Langohr K, Covas MI, Pérez-Mañá C, Fitó M, Tyndale RF, et al. Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans. Data in Brief. 27: 104787. PMID 31788516 DOI: 10.1016/j.dib.2019.104787  0.095
2023 Boachie N, Gaudette E, Bazinet RP, Lin L, Tyndale RF, Mansouri E, Huestis MA, Tong J, Le Foll B, Kish SJ, George TP, Boileau I. Circulating Endocannabinoids and N-Acylethanolamines in Individuals with Cannabis Use Disorder-Preliminary Findings. Brain Sciences. 13. PMID 37891745 DOI: 10.3390/brainsci13101375  0.095
1989 Tyndale RF, Inaba T, Kalow W. Evidence in humans for variant allozymes of the nondeficient sparteine/debrisoquine monooxygenase (P45OIID 1) in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 17: 334-40. PMID 2568917  0.095
2012 Miksys SL, Uhl K, Tyndale RF. Twenty-first-century neuroscience: the potential for innovative therapies for brain disorders. Clinical Pharmacology and Therapeutics. 91: 153-7. PMID 22261679 DOI: 10.1038/clpt.2011.310  0.076
1991 Someya T, Inaba T, Tyndale RF, Tang SW, Takahashi S. Conversion of bromperidol to reduced bromperidol in human liver. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 5: 177-82. PMID 1755933  0.074
2011 Roden DM, Tyndale RF. Pharmacogenomics at the tipping point: challenges and opportunities. Clinical Pharmacology and Therapeutics. 89: 323-7. PMID 21326256 DOI: 10.1038/Clpt.2010.340  0.072
2021 Green DGJ, Kim J, Kish SJ, Tyndale RF, Hill MN, Strafella AP, Tong J, McCluskey T, Westwood DJ, Houle S, Lobaugh NJ, Boileau I. Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals. Journal of Psychiatry & Neuroscience : Jpn. 46: E238-E246. PMID 33729738 DOI: 10.1503/jpn.200010  0.069
2012 McDonagh EM, Wassenaar C, David SP, Tyndale RF, Altman RB, Whirl-Carrillo M, Klein TE. PharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6. Pharmacogenetics and Genomics. 22: 695-708. PMID 22547082 DOI: 10.1097/FPC.0b013e3283540217  0.068
2017 Jukić MM, Opel N, Ström J, Carrillo-Roa T, Miksys S, Novalen M, Renblom A, Sim SC, Peñas-Lledó EM, Courtet P, Llerena A, Baune BT, de Quervain DJ, Papassotiropoulos A, Tyndale RF, et al. Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment. Molecular Psychiatry. PMID 28416806 DOI: 10.1038/mp.2017.93  0.066
2002 Field JK, Brambilla C, Caporaso N, Flahault A, Henschke C, Herman J, Hirsch F, Lachmann P, Lam S, Maier S, Montuenga LM, Mulshine J, Murphy M, Pullen J, Spitz M, ... ... Tyndale R, et al. Consensus statements from the Second International Lung Cancer Molecular Biomarkers Workshop: a European strategy for developing lung cancer molecular diagnostics in high risk populations. International Journal of Oncology. 21: 369-73. PMID 12118333 DOI: 10.3892/ijo.21.2.369  0.047
2013 Roden DM, Tyndale RF. Genomic medicine, precision medicine, personalized medicine: what's in a name? Clinical Pharmacology and Therapeutics. 94: 169-72. PMID 23872826 DOI: 10.1038/clpt.2013.101  0.041
2010 Miksys SL, Tyndale RF. Neurodegenerative diseases: a growing challenge. Clinical Pharmacology and Therapeutics. 88: 427-30. PMID 20856233 DOI: 10.1038/clpt.2010.198  0.014
2006 Jarvis MJ, Perkins K, Picciotto MR, Clarke PBS, Corrigall WA, Shiffman S, Balfour D, Caggiula A, Tyndale RF, Bertrand D. General discussion I Novartis Foundation Symposium. 275: 59-63.  0.01
2006 Tyndale RF, Shiffman S, Brody AL, Clarke PBS, Walton R, Jarvis MJ, Hajek P, West R, Perkins K, Balfour D, Stolerman I. Discussion Novartis Foundation Symposium. 275: 231-234.  0.01
2006 Markou A, Jarvis MJ, Stolerman I, Picciotto MR, Perkins K, Chiamulera C, Shiffman S, Caggiula A, Hajek P, Tyndale RF, Bertrand D, Balfour D, Bizarro L. Final discussion Novartis Foundation Symposium. 275: 262-265.  0.01
2006 Chiamulera C, Picciotto MR, Balfour D, Bertrand D, Clarke PBS, Corrigall WA, Caggiula A, Tyndale RF, Brody AL, Shiffman S, West R. Discussion Novartis Foundation Symposium. 275: 90-95.  0.01
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