George Georgiou - Publications

Biomedical Engineering University of Texas at Austin, Austin, Texas, U.S.A. 
discovery and development of protein therapeutics and applied immunology by capitalizing on state of the art protein engineering, directed evolution and systems biology technologies

232 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Goike J, Hsieh CL, Horton AP, Gardner EC, Zhou L, Bartzoka F, Wang N, Javanmardi K, Herbert A, Abbassi S, Xie X, Xia H, Shi PY, Renberg R, Segall-Shapiro TH, ... ... Georgiou G, et al. SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode. Communications Biology. 6: 1250. PMID 38082099 DOI: 10.1038/s42003-023-05649-6  0.501
2022 Kuraoka M, Curtis NC, Watanabe A, Tanno H, Shin S, Ye K, Macdonald E, Lavidor O, Kong S, Von Holle T, Windsor I, Ippolito GC, Georgiou G, Walter EB, Kelsoe G, et al. Infant Antibody Repertoires during the First Two Years of Influenza Vaccination. Mbio. e0254622. PMID 36314798 DOI: 10.1128/mbio.02546-22  0.387
2021 Charab W, Rosenberger MG, Shivram H, Mirazee JM, Donkor M, Shekhar SR, Gjuka D, Khoo KH, Kim JE, Iyer VR, Georgiou G. IgG Immune Complexes Inhibit Naïve T Cell Proliferation and Suppress Effector Function in Cytotoxic T Cells. Frontiers in Immunology. 12: 713704. PMID 34447380 DOI: 10.3389/fimmu.2021.713704  0.551
2021 Jung J, Mundle ST, Ustyugova IV, Horton AP, Boutz DR, Pougatcheva S, Prabakaran P, McDaniel JR, King GR, Park D, Person MD, Ye C, Tan B, Tanno Y, Kim JE, ... ... Georgiou G, et al. Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans. The Journal of Clinical Investigation. 131. PMID 34196304 DOI: 10.1172/JCI148763  0.732
2021 McCarthy KR, Lee J, Watanabe A, Kuraoka M, Robinson-McCarthy LR, Georgiou G, Kelsoe G, Harrison SC. A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface. Mbio. e0114421. PMID 34060327 DOI: 10.1128/mBio.01144-21  0.454
2021 Goike J, Hsieh CL, Horton A, Gardner EC, Bartzoka F, Wang N, Javanmardi K, Herbert A, Abbassi S, Renberg R, Johanson MJ, Cardona JA, Segall-Shapiro T, Zhou L, Nissly RH, ... ... Georgiou G, et al. Synthetic repertoires derived from convalescent COVID-19 patients enable discovery of SARS-CoV-2 neutralizing antibodies and a novel quaternary binding modality. Biorxiv : the Preprint Server For Biology. PMID 33851158 DOI: 10.1101/2021.04.07.438849  0.524
2021 Denard CA, Paresi C, Yaghi R, McGinnis N, Bennett Z, Yi L, Georgiou G, Iverson BL. YESS 2.0, a Tunable Platform for Enzyme Evolution, Yields Highly Active TEV Protease Variants. Acs Synthetic Biology. PMID 33401904 DOI: 10.1021/acssynbio.0c00452  0.779
2020 Mehaffey MR, Lee J, Jung J, Lanzillotti MB, Escobar EE, Morgenstern KR, Georgiou G, Brodbelt JS. Mapping a Conformational Epitope of Hemagglutinin A Using Native Mass Spectrometry and Ultraviolet Photodissociation. Analytical Chemistry. 92: 11869-11878. PMID 32867493 DOI: 10.1021/Acs.Analchem.0C02237  0.463
2020 Soni C, Perez OA, Voss WN, Pucella JN, Serpas L, Mehl J, Ching KL, Goike J, Georgiou G, Ippolito GC, Sisirak V, Reizis B. Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA. Immunity. PMID 32454024 DOI: 10.1016/J.Immuni.2020.04.015  0.319
2020 Tanno H, McDaniel JR, Stevens CA, Voss WN, Li J, Durrett R, Lee J, Gollihar J, Tanno Y, Delidakis G, Pothukuchy A, Ellefson JW, Goronzy JJ, Maynard JA, Ellington AD, ... ... Georgiou G, et al. A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires. Science Advances. 6: eaay9093. PMID 32426460 DOI: 10.1126/Sciadv.Aay9093  0.686
2020 Lee J, Der BS, Karamitros CS, Li W, Marshall NM, Lungu OI, Miklos AE, Xu J, Kang TH, Lee CH, Tan B, Hughes RA, Jung ST, Ippolito GC, Gray JJ, ... ... Georgiou G, et al. Computer-based Engineering of Thermostabilized Antibody Fragments. Aiche Journal. American Institute of Chemical Engineers. 66. PMID 32336757 DOI: 10.1002/Aic.16864  0.801
2019 Tanno H, Gould TM, McDaniel JR, Cao W, Tanno Y, Durrett RE, Park D, Cate SJ, Hildebrand WH, Dekker CL, Tian L, Weyand CM, Georgiou G, Goronzy JJ. Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins. Proceedings of the National Academy of Sciences of the United States of America. PMID 31879353 DOI: 10.1073/Pnas.1915008117  0.697
2019 Lee CH, Kang TH, Godon O, Watanabe M, Delidakis G, Gillis CM, Sterlin D, Hardy D, Cogné M, Macdonald LE, Murphy AJ, Tu N, Lee J, McDaniel JR, Makowski E, ... ... Georgiou G, et al. Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence. Nature Communications. 10: 5461. PMID 31767870 DOI: 10.1038/S41467-019-13458-X  0.754
2019 Lee CH, Kang TH, Godon O, Watanabe M, Delidakis G, Gillis CM, Sterlin D, Hardy D, Cogné M, Macdonald LE, Murphy AJ, Tu N, Lee J, McDaniel JR, Makowski E, ... ... Georgiou G, et al. An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence. Nature Communications. 10: 5031. PMID 31695028 DOI: 10.1038/S41467-019-13108-2  0.795
2019 Lindesmith LC, McDaniel JR, Changela A, Verardi R, Kerr SA, Costantini V, Brewer-Jensen PD, Mallory ML, Voss WN, Boutz DR, Blazeck JJ, Ippolito GC, Vinje J, Kwong PD, Georgiou G, et al. Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination. Immunity. 50: 1530-1541.e8. PMID 31216462 DOI: 10.1016/J.Immuni.2019.05.007  0.36
2019 Kang TH, Lee CH, Delidakis G, Jung J, Richard-Le Goff O, Lee J, Kim JE, Charab W, Bruhns P, Georgiou G. An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIa Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages. Frontiers in Immunology. 10: 562. PMID 30984171 DOI: 10.3389/Fimmu.2019.00562  0.806
2019 Krebs SJ, Kwon YD, Schramm CA, Law WH, Donofrio G, Zhou KH, Gift S, Dussupt V, Georgiev IS, Schätzle S, McDaniel JR, Lai YT, Sastry M, Zhang B, Jarosinski MC, ... ... Georgiou G, et al. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity. PMID 30876875 DOI: 10.1016/J.Immuni.2019.02.008  0.351
2019 Lee J, Paparoditis P, Horton AP, Frühwirth A, McDaniel JR, Jung J, Boutz DR, Hussein DA, Tanno Y, Pappas L, Ippolito GC, Corti D, Lanzavecchia A, Georgiou G. Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations. Cell Host & Microbe. PMID 30795981 DOI: 10.1016/J.Chom.2019.01.010  0.495
2019 Coma S, Cavanaugh J, Nolan J, Tchaicha J, McGovern K, Stone E, Blazeck J, Lamb C, Georgiou G, Manfredi MG, Zhang M. Abstract B008: Treatment of IDO1 and TDO2 positive tumors with a kynurenine-degrading enzyme: A highly differentiated approach from IDO1 inhibition Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B008  0.308
2019 Gjuka D, Georgiou G, Stone EM. Abstract LB-A18: The frequent tumor deletion of MTAP is a newly recognized potent immune checkpoint that is effectively reversed by a human methylthioadenosine degrading drug candidate Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Lb-A18  0.311
2018 Johnson EL, Doria-Rose NA, Gorman J, Bhiman JN, Schramm CA, Vu AQ, Law WH, Zhang B, Bekker V, Abdool Karim SS, Ippolito GC, Morris L, Moore PL, Kwong PD, Mascola JR, ... Georgiou G, et al. Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation. Nature Communications. 9: 4136. PMID 30297708 DOI: 10.1038/S41467-018-06424-6  0.334
2018 Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, ... ... Georgiou G, et al. Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell. 174: 938-952.e13. PMID 30096313 DOI: 10.1016/J.Cell.2018.07.033  0.38
2018 Lee J, Georgiou G. High-affinity IgA against microbial glycans. Nature Immunology. PMID 29777208 DOI: 10.1038/S41590-018-0116-0  0.531
2018 Liu Y, McDaniel JR, Khan S, Campisi P, Propst EJ, Holler T, Grunebaum E, Georgiou G, Ippolito GC, Ehrhardt GRA. Antibodies Encoded by FCRL4-Bearing Memory B Cells Preferentially Recognize Commensal Microbial Antigens. Journal of Immunology (Baltimore, Md. : 1950). PMID 29703863 DOI: 10.4049/Jimmunol.1701549  0.337
2018 Chen YQ, Wohlbold TJ, Zheng NY, Huang M, Huang Y, Neu KE, Lee J, Wan H, Rojas KT, Kirkpatrick E, Henry C, Palm AE, Stamper CT, Lan LY, Topham DJ, ... ... Georgiou G, et al. Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies. Cell. 173: 417-429.e10. PMID 29625056 DOI: 10.1016/J.Cell.2018.03.030  0.467
2018 McDaniel JR, Pero SC, Voss WN, Shukla GS, Sun Y, Schaetzle S, Lee CH, Horton AP, Harlow S, Gollihar J, Ellefson JW, Krag CC, Tanno Y, Sidiropoulos N, Georgiou G, et al. Identification of tumor-reactive B cells and systemic IgG in breast cancer based on clonal frequency in the sentinel lymph node. Cancer Immunology, Immunotherapy : Cii. PMID 29427082 DOI: 10.1007/S00262-018-2123-2  0.304
2018 Wang B, DeKosky BJ, Timm MR, Lee J, Normandin E, Misasi J, Kong R, McDaniel JR, Delidakis G, Leigh KE, Niezold T, Choi CW, Viox EG, Fahad A, Cagigi A, ... ... Georgiou G, et al. Functional interrogation and mining of natively paired human VH:VL antibody repertoires. Nature Biotechnology. PMID 29309060 DOI: 10.1038/Nbt.4052  0.633
2017 Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, ... ... Georgiou G, et al. Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions. Nature Immunology. 18: 1173. PMID 28926542 DOI: 10.1038/Ni1017-1173C  0.759
2017 McDaniel JR, Ippolito GC, Georgiou G. Mapping the secrets of the antibody pool. Nature Biotechnology. PMID 28892077 DOI: 10.1038/Nbt.3972  0.365
2017 Williams LD, Ofek G, Schätzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, ... ... Georgiou G, et al. Potent and broad HIV-neutralizing antibodies in memory B cells and plasma. Science Immunology. 2. PMID 28783671 DOI: 10.1126/Sciimmunol.Aal2200  0.326
2017 Kim SJ, Schätzle S, Ahmed SS, Haap W, Jang SH, Gregersen PK, Georgiou G, Diamond B. Increased cathepsin S in Prdm1(-/-) dendritic cells alters the TFH cell repertoire and contributes to lupus. Nature Immunology. PMID 28692065 DOI: 10.1038/Ni.3793  0.305
2017 Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, ... ... Georgiou G, et al. IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions. Nature Immunology. PMID 28604720 DOI: 10.1038/Ni.3770  0.804
2017 Cotham VC, Horton AP, Lee J, Georgiou G, Brodbelt JS. Middle-Down 193 nm Ultraviolet Photodissociation for Unambiguous Antibody Identification and its Implications for Immunoproteomic Analysis. Analytical Chemistry. PMID 28517930 DOI: 10.1021/Acs.Analchem.7B00564  0.543
2017 Triplett TA, Triplett K, Stone E, Zhang M, Manfredi M, Lamb C, Tanno Y, Ehrlich L, Georgiou G. Abstract 5571: Immune-checkpoint inhibition via enzyme-mediated degradation of kynurenine Cancer Research. 77: 5571-5571. DOI: 10.1158/1538-7445.Am2017-5571  0.304
2017 Zhang M, Stone E, Triplett TA, Triplett K, Lamb C, Karamitros CS, Blazek J, Georgiou G, Manfredi MG. Abstract 5570: A novel approach to targeting the IDO/TDO pathway through degradation of the immunosuppressive metabolite kynurenine Cancer Research. 77: 5570-5570. DOI: 10.1158/1538-7445.Am2017-5570  0.303
2016 Wu GC, Cheung NV, Georgiou G, Marcotte EM, Ippolito GC. Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire. Nature Communications. 7: 13838. PMID 28000661 DOI: 10.1038/Ncomms13838  0.308
2016 Li Q, Yi L, Hoi KH, Marek P, Georgiou G, Iverson BL. Profiling Protease Specificity: Combining Yeast ER Sequestration Screening (YESS) with Next Generation Sequencing. Acs Chemical Biology. PMID 27977123 DOI: 10.1021/Acschembio.6B00547  0.359
2016 Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas PV, ... ... Georgiou G, et al. Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nature Medicine. PMID 27820605 DOI: 10.1038/Nm.4224  0.777
2016 Raymond DD, Stewart SM, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre EC, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, et al. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nature Medicine. PMID 27820604 DOI: 10.1038/Nm.4223  0.766
2016 Wang B, Kluwe CA, Lungu OI, DeKosky BJ, Kerr SA, Johnson EL, Tanno H, Lee CH, Jung J, Rezigh AB, Carroll SM, Reyes AN, Bentz JR, Villanueva I, Altman AL, ... ... Georgiou G, et al. Corrigendum: Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining. Scientific Reports. 6: 27229. PMID 27282782 DOI: 10.1038/Srep27229  0.614
2016 Wang B, Lee CH, Johnson EL, Kluwe CA, Cunningham JC, Tanno H, Crooks RM, Georgiou G, Ellington AD. Discovery of high affinity anti-ricin antibodies by B cell receptor sequencing and by yeast display of combinatorial VH:VL libraries from immunized animals. Mabs. 0. PMID 27224530 DOI: 10.1080/19420862.2016.1190059  0.565
2016 DeKosky BJ, Lungu OI, Park D, Johnson EL, Charab W, Chrysostomou C, Kuroda D, Ellington AD, Ippolito GC, Gray JJ, Georgiou G. Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114511 DOI: 10.1073/Pnas.1525510113  0.773
2016 Brezski RJ, Georgiou G. Immunoglobulin isotype knowledge and application to Fc engineering. Current Opinion in Immunology. 40: 62-69. PMID 27003675 DOI: 10.1016/J.Coi.2016.03.002  0.404
2016 McDaniel JR, DeKosky BJ, Tanno H, Ellington AD, Georgiou G. Ultra-high-throughput sequencing of the immune receptor repertoire from millions of lymphocytes. Nature Protocols. 11: 429-42. PMID 26844430 DOI: 10.1038/Nprot.2016.024  0.492
2016 Dekker JD, Park D, Shaffer AL, Kohlhammer H, Deng W, Lee BK, Ippolito GC, Georgiou G, Iyer VR, Staudt LM, Tucker HO. Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787899 DOI: 10.1073/Pnas.1524677113  0.768
2016 Agnello G, Alters S, Tyler J, Liu J, Huang P, Stone E, Georgiou G, Lowe D, Rowlinson S. Development of a Human Therapeutic L-Cyst(e)Ine-Degrading Enzyme for the Treatment of Hematological Malignancies Blood. 128: 1587-1587. DOI: 10.1182/Blood.V128.22.1587.1587  0.306
2015 Gorman J, Soto C, Yang MM, Davenport TM, Guttman M, Bailer RT, Chambers M, Chuang GY, DeKosky BJ, Doria-Rose NA, Druz A, Ernandes MJ, Georgiev IS, Jarosinski MC, Joyce MG, ... ... Georgiou G, et al. Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nature Structural & Molecular Biology. PMID 26689967 DOI: 10.1038/Nsmb.3144  0.379
2015 Quandt EM, Gollihar J, Blount ZD, Ellington AD, Georgiou G, Barrick JE. Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment. Elife. 4. PMID 26465114 DOI: 10.7554/Elife.09696  0.456
2015 Kerr SA, Jackson EL, Lungu OI, Meyer AG, Demogines A, Ellington AD, Georgiou G, Wilke CO, Sawyer SL. Computational and Functional Analysis of the Virus-Receptor Interface Reveals Host Range Trade-Offs in New World Arenaviruses. Journal of Virology. 89: 11643-53. PMID 26355089 DOI: 10.1128/Jvi.01408-15  0.458
2015 Wang B, Kluwe CA, Lungu OI, DeKosky BJ, Kerr SA, Johnson EL, Jung J, Rezigh AB, Carroll SM, Reyes AN, Bentz JR, Villanueva I, Altman AL, Davey RA, Ellington AD, ... Georgiou G, et al. Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining. Scientific Reports. 5: 13926. PMID 26355042 DOI: 10.1038/Srep13926  0.707
2015 Wine Y, Horton AP, Ippolito GC, Georgiou G. Serology in the 21st century: the molecular-level analysis of the serum antibody repertoire. Current Opinion in Immunology. 35: 89-97. PMID 26172290 DOI: 10.1016/J.Coi.2015.06.009  0.374
2015 Yi L, Taft JM, Li Q, Gebhard MC, Georgiou G, Iverson BL. Yeast Endoplasmic Reticulum Sequestration Screening for the Engineering of Proteases from Libraries Expressed in Yeast. Methods in Molecular Biology (Clifton, N.J.). 1319: 81-93. PMID 26060071 DOI: 10.1007/978-1-4939-2748-7_5  0.327
2015 Chrysostomou C, Quandt EM, Marshall NM, Stone E, Georgiou G. An alternate pathway of arsenate resistance in E. coli mediated by the glutathione S-transferase GstB. Acs Chemical Biology. 10: 875-82. PMID 25517993 DOI: 10.1021/Cb500755J  0.337
2015 DeKosky BJ, Kojima T, Rodin A, Charab W, Ippolito GC, Ellington AD, Georgiou G. In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire. Nature Medicine. 21: 86-91. PMID 25501908 DOI: 10.1038/Nm.3743  0.546
2015 Lavinder JJ, Horton AP, Georgiou G, Ippolito GC. Next-generation sequencing and protein mass spectrometry for the comprehensive analysis of human cellular and serum antibody repertoires. Current Opinion in Chemical Biology. 24: 112-20. PMID 25461729 DOI: 10.1016/J.Cbpa.2014.11.007  0.424
2015 Stone E, Marshall N, Donkor M, Triplett K, Blazek J, Triplett T, Ehrlich L, Georgiou G. Abstract LB-226: Depletion of kynurenine using an engineered therapeutic enzyme potently inhibits cancer immune checkpoints both as a monotherapy and in combination with anti-PD-1 Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-226  0.302
2014 Kelton W, Mehta N, Charab W, Lee J, Lee CH, Kojima T, Kang TH, Georgiou G. IgGA: a "cross-isotype" engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions. Chemistry & Biology. 21: 1603-9. PMID 25500223 DOI: 10.1016/J.Chembiol.2014.10.017  0.802
2014 Romain G, Senyukov V, Rey-Villamizar N, Merouane A, Kelton W, Liadi I, Mahendra A, Charab W, Georgiou G, Roysam B, Lee DA, Varadarajan N. Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells. Blood. 124: 3241-9. PMID 25232058 DOI: 10.1182/Blood-2014-04-569061  0.348
2014 Lavinder JJ, Hoi KH, Reddy ST, Wine Y, Georgiou G. Systematic characterization and comparative analysis of the rabbit immunoglobulin repertoire. Plos One. 9: e101322. PMID 24978027 DOI: 10.1371/Journal.Pone.0101322  0.308
2014 Boutz DR, Horton AP, Wine Y, Lavinder JJ, Georgiou G, Marcotte EM. Proteomic identification of monoclonal antibodies from serum. Analytical Chemistry. 86: 4758-66. PMID 24684310 DOI: 10.1021/Ac4037679  0.358
2014 Mroczek ES, Ippolito GC, Rogosch T, Hoi KH, Hwangpo TA, Brand MG, Zhuang Y, Liu CR, Schneider DA, Zemlin M, Brown EE, Georgiou G, Schroeder HW. Differences in the composition of the human antibody repertoire by B cell subsets in the blood. Frontiers in Immunology. 5: 96. PMID 24678310 DOI: 10.3389/Fimmu.2014.00096  0.362
2014 Laserson U, Vigneault F, Gadala-Maria D, Yaari G, Uduman M, Vander Heiden JA, Kelton W, Taek Jung S, Liu Y, Laserson J, Chari R, Lee JH, Bachelet I, Hickey B, Lieberman-Aiden E, ... ... Georgiou G, et al. High-resolution antibody dynamics of vaccine-induced immune responses. Proceedings of the National Academy of Sciences of the United States of America. 111: 4928-33. PMID 24639495 DOI: 10.1073/Pnas.1323862111  0.366
2014 Doria-Rose NA, Schramm CA, Gorman J, Moore PL, Bhiman JN, DeKosky BJ, Ernandes MJ, Georgiev IS, Kim HJ, Pancera M, Staupe RP, Altae-Tran HR, Bailer RT, Crooks ET, Cupo A, ... ... Georgiou G, et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature. 509: 55-62. PMID 24590074 DOI: 10.1038/Nature13036  0.354
2014 Lavinder JJ, Wine Y, Giesecke C, Ippolito GC, Horton AP, Lungu OI, Hoi KH, DeKosky BJ, Murrin EM, Wirth MM, Ellington AD, Dörner T, Marcotte EM, Boutz DR, Georgiou G. Identification and characterization of the constituent human serum antibodies elicited by vaccination. Proceedings of the National Academy of Sciences of the United States of America. 111: 2259-64. PMID 24469811 DOI: 10.1073/Pnas.1317793111  0.519
2014 Georgiou G, Ippolito GC, Beausang J, Busse CE, Wardemann H, Quake SR. The promise and challenge of high-throughput sequencing of the antibody repertoire. Nature Biotechnology. 32: 158-68. PMID 24441474 DOI: 10.1038/Nbt.2782  0.346
2014 Quandt EM, Deatherage DE, Ellington AD, Georgiou G, Barrick JE. Recursive genomewide recombination and sequencing reveals a key refinement step in the evolution of a metabolic innovation in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 111: 2217-22. PMID 24379390 DOI: 10.1073/Pnas.1314561111  0.478
2013 Agnello G, Chang LL, Lamb CM, Georgiou G, Stone EM. Discovery of a substrate selectivity motif in amino acid decarboxylases unveils a taurine biosynthesis pathway in prokaryotes. Acs Chemical Biology. 8: 2264-71. PMID 23972067 DOI: 10.1021/Cb400335K  0.306
2013 Der BS, Kluwe C, Miklos AE, Jacak R, Lyskov S, Gray JJ, Georgiou G, Ellington AD, Kuhlman B. Alternative computational protocols for supercharging protein surfaces for reversible unfolding and retention of stability. Plos One. 8: e64363. PMID 23741319 DOI: 10.1371/Journal.Pone.0064363  0.473
2013 Yi L, Gebhard MC, Li Q, Taft JM, Georgiou G, Iverson BL. Engineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial libraries. Proceedings of the National Academy of Sciences of the United States of America. 110: 7229-34. PMID 23589865 DOI: 10.1073/Pnas.1215994110  0.377
2013 Carroll S, Georgiou G. Antibody-mediates inhibition of human C1s and the classical complement pathway. Immunobiology. 218: 1041-8. PMID 23434433 DOI: 10.1016/J.Imbio.2013.01.001  0.626
2013 Paley O, Agnello G, Cantor J, Yoo TH, Georgiou G, Stone E. GFP reporter screens for the engineering of amino acid degrading enzymes from libraries expressed in bacteria. Methods in Molecular Biology (Clifton, N.J.). 978: 31-44. PMID 23423887 DOI: 10.1007/978-1-62703-293-3_3  0.334
2013 Wine Y, Boutz DR, Lavinder JJ, Miklos AE, Hughes RA, Hoi KH, Jung ST, Horton AP, Murrin EM, Ellington AD, Marcotte EM, Georgiou G. Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response. Proceedings of the National Academy of Sciences of the United States of America. 110: 2993-8. PMID 23382245 DOI: 10.1073/Pnas.1213737110  0.761
2013 DeKosky BJ, Ippolito GC, Deschner RP, Lavinder JJ, Wine Y, Rawlings BM, Varadarajan N, Giesecke C, Dörner T, Andrews SF, Wilson PC, Hunicke-Smith SP, Willson CG, Ellington AD, Georgiou G. High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nature Biotechnology. 31: 166-9. PMID 23334449 DOI: 10.1038/Nbt.2492  0.479
2013 Needham BD, Carroll SM, Giles DK, Georgiou G, Whiteley M, Trent MS. Modulating the innate immune response by combinatorial engineering of endotoxin. Proceedings of the National Academy of Sciences of the United States of America. 110: 1464-9. PMID 23297218 DOI: 10.1073/Pnas.1218080110  0.578
2013 Mittal J, Yoo TH, Georgiou G, Truskett TM. Structural ensemble of an intrinsically disordered polypeptide. The Journal of Physical Chemistry. B. 117: 118-24. PMID 23205890 DOI: 10.1021/Jp308984E  0.527
2013 Jung ST, Kelton W, Kang TH, Ng DT, Andersen JT, Sandlie I, Sarkar CA, Georgiou G. Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity. Acs Chemical Biology. 8: 368-75. PMID 23030766 DOI: 10.1021/Cb300455F  0.814
2013 Romain G, Senyukov VV, Liadi I, Kelton W, Georgiou G, Lee DA, Varadarajan N. Single-cell quantification of functional outcomes of CD16 ligation in NK cells by Fc-engineered antibodies Journal For Immunotherapy of Cancer. 1. DOI: 10.1186/2051-1426-1-S1-O5  0.35
2012 Saggy I, Wine Y, Shefet-Carasso L, Nahary L, Georgiou G, Benhar I. Antibody isolation from immunized animals: comparison of phage display and antibody discovery via V gene repertoire mining. Protein Engineering, Design & Selection : Peds. 25: 539-49. PMID 22988130 DOI: 10.1093/Protein/Gzs060  0.409
2012 Li W, Cantor JR, Yogesha SD, Yang S, Chantranupong L, Liu JQ, Agnello G, Georgiou G, Stone EM, Zhang Y. Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. Acs Chemical Biology. 7: 1840-7. PMID 22891768 DOI: 10.1021/Cb300232N  0.318
2012 Borrok MJ, Jung ST, Kang TH, Monzingo AF, Georgiou G. Revisiting the role of glycosylation in the structure of human IgG Fc. Acs Chemical Biology. 7: 1596-602. PMID 22747430 DOI: 10.1021/Cb300130K  0.795
2012 Romero PA, Stone E, Lamb C, Chantranupong L, Krause A, Miklos AE, Hughes RA, Fechtel B, Ellington AD, Arnold FH, Georgiou G. SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis. Acs Synthetic Biology. 1: 221-8. PMID 22737599 DOI: 10.1021/Sb300014T  0.594
2012 Rani M, Bolles M, Donaldson EF, Van Blarcom T, Baric R, Iverson B, Georgiou G. Increased antibody affinity confers broad in vitro protection against escape mutants of severe acute respiratory syndrome coronavirus. Journal of Virology. 86: 9113-21. PMID 22696652 DOI: 10.1128/Jvi.00233-12  0.769
2012 Skretas G, Makino T, Varadarajan N, Pogson M, Georgiou G. Multi-copy genes that enhance the yield of mammalian G protein-coupled receptors in Escherichia coli. Metabolic Engineering. 14: 591-602. PMID 22609824 DOI: 10.1016/J.Nbt.2012.08.406  0.376
2012 Ippolito GC, Hoi KH, Reddy ST, Carroll SM, Ge X, Rogosch T, Zemlin M, Shultz LD, Ellington AD, Vandenberg CL, Georgiou G. Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. Plos One. 7: e35497. PMID 22558161 DOI: 10.1371/Journal.Pone.0035497  0.626
2012 Miklos AE, Kluwe C, Der BS, Pai S, Sircar A, Hughes RA, Berrondo M, Xu J, Codrea V, Buckley PE, Calm AM, Welsh HS, Warner CR, Zacharko MA, Carney JP, ... ... Georgiou G, et al. Structure-based design of supercharged, highly thermoresistant antibodies. Chemistry & Biology. 19: 449-55. PMID 22520751 DOI: 10.1016/J.Chembiol.2012.01.018  0.802
2012 Yoo TH, Pogson M, Iverson BL, Georgiou G. Directed evolution of highly selective proteases by using a novel FACS-based screen that capitalizes on the p53 regulator MDM2. Chembiochem : a European Journal of Chemical Biology. 13: 649-53. PMID 22334509 DOI: 10.1002/Cbic.201100718  0.327
2012 Cantor JR, Panayiotou V, Agnello G, Georgiou G, Stone EM. Engineering reduced-immunogenicity enzymes for amino acid depletion therapy in cancer. Methods in Enzymology. 502: 291-319. PMID 22208990 DOI: 10.1016/B978-0-12-416039-2.00015-X  0.324
2012 Stone E, Chantranupong L, Gonzalez C, O'Neal J, Rani M, VanDenBerg C, Georgiou G. Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 158: 171-9. PMID 22001609 DOI: 10.1016/J.Jconrel.2011.09.097  0.326
2012 Freeman A, Abramov S, Georgiou G. Fixation and stabilization of Escherichia coli cells displaying genetically engineered cell surface proteins. Biotechnology and Bioengineering. 52: 625-30. PMID 18629936 DOI: 10.1002/(Sici)1097-0290(19961205)52:5<625::Aid-Bit10>3.0.Co;2-E  0.345
2012 Georgiou G, Shuler ML. A computer model for the growth and differentiation of a fungal colony on solid substrate. Biotechnology and Bioengineering. 28: 405-16. PMID 18555342 DOI: 10.1002/Bit.260280314  0.462
2012 Senyukov V, Kelton W, Mehta N, Georgiou G, Lee D. Engineering Anti-AML Antibodies for Improved NK Cell ADCC Blood. 120: 3629-3629. DOI: 10.1182/Blood.V120.21.3629.3629  0.375
2012 Xu J, Miklos AE, Hughes R, Kuhlman B, Georgiou G, Ellington AD, Gray JJ. A Systematic Computational Method to Predict and Enhance Antibody-Antigen Binding in the Absence of Antibody Crystal Structures Biophysical Journal. 102: 621a. DOI: 10.1016/J.Bpj.2011.11.3382  0.546
2011 Reddy ST, Georgiou G. Systems analysis of adaptive immunity by utilization of high-throughput technologies. Current Opinion in Biotechnology. 22: 584-9. PMID 21570821 DOI: 10.1016/J.Copbio.2011.04.015  0.3
2011 Makino T, Skretas G, Georgiou G. Strain engineering for improved expression of recombinant proteins in bacteria. Microbial Cell Factories. 10: 32. PMID 21569582 DOI: 10.1186/1475-2859-10-32  0.36
2011 Feeney MA, Veeravalli K, Boyd D, Gon S, Faulkner MJ, Georgiou G, Beckwith J. Repurposing lipoic acid changes electron flow in two important metabolic pathways of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 7991-6. PMID 21521794 DOI: 10.1073/Pnas.1105429108  0.343
2011 Jung ST, Kang TH, Kelton W, Georgiou G. Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy. Current Opinion in Biotechnology. 22: 858-67. PMID 21420850 DOI: 10.1016/J.Copbio.2011.03.002  0.808
2011 Cantor JR, Yoo TH, Dixit A, Iverson BL, Forsthuber TG, Georgiou G. Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. Proceedings of the National Academy of Sciences of the United States of America. 108: 1272-7. PMID 21209329 DOI: 10.1073/Pnas.1014739108  0.393
2011 Veeravalli K, Boyd D, Iverson BL, Beckwith J, Georgiou G. Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways. Nature Chemical Biology. 7: 101-5. PMID 21186348 DOI: 10.1038/Nchembio.499  0.339
2011 Makino T, Skretas G, Kang TH, Georgiou G. Comprehensive engineering of Escherichia coli for enhanced expression of IgG antibodies Metabolic Engineering. 13: 241-251. PMID 21130896 DOI: 10.1016/J.Ymben.2010.11.002  0.776
2011 Cao Y, Marks JW, Carroll S, Georgiou G, Hittelman WN, Rosenblum MG. Abstract 1759: Design optimization and characterization of novel herceptin-based immunotoxins for cancer therapy. Enhanced antitumor activity in vitro and in vivo Cancer Research. 71: 1759-1759. DOI: 10.1158/1538-7445.Am2011-1759  0.615
2011 Arredondo SA, Georgiou G. The problem of expression of multidisulfide bonded recombinant proteins in E. coli Protein Reviews. 14: 183-215. DOI: 10.1007/978-1-4419-7273-6-9  0.741
2010 Qiu JK, Jung ST, Georgiou G, Hang HY. Enrichment of Escherichia coli spheroplasts displaying scFv antibodies specific for antigens expressed on the human cell surface. Applied Microbiology and Biotechnology. 88: 1385-91. PMID 20878322 DOI: 10.1007/S00253-010-2861-3  0.784
2010 Reddy ST, Ge X, Miklos AE, Hughes RA, Kang SH, Hoi KH, Chrysostomou C, Hunicke-Smith SP, Iverson BL, Tucker PW, Ellington AD, Georgiou G. Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nature Biotechnology. 28: 965-9. PMID 20802495 DOI: 10.1038/Nbt.1673  0.559
2010 Skretas G, Georgiou G. Simple genetic selection protocol for isolation of overexpressed genes that enhance accumulation of membrane-integrated human G protein-coupled receptors in Escherichia coli Applied and Environmental Microbiology. 76: 5852-5859. PMID 20639362 DOI: 10.1128/Aem.00963-10  0.36
2010 Jung ST, Kang TH, Georgiou G. Efficient expression and purification of human aglycosylated Fcgamma receptors in Escherichia coli. Biotechnology and Bioengineering. 107: 21-30. PMID 20506277 DOI: 10.1002/Bit.22785  0.817
2010 Mazor Y, Van Blarcom T, Carroll S, Georgiou G. Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening. The Febs Journal. 277: 2291-303. PMID 20423457 DOI: 10.1111/J.1742-4658.2010.07645.X  0.812
2010 Van Blarcom TJ, Sofer-Podesta C, Ang J, Boyer JL, Crystal RG, Georgiou G. Affinity maturation of an anti-V antigen IgG expressed in situ through adenovirus gene delivery confers enhanced protection against Yersinia pestis challenge. Gene Therapy. 17: 913-21. PMID 20393511 DOI: 10.1038/Gt.2010.42  0.763
2010 Ge X, Mazor Y, Hunicke-Smith SP, Ellington AD, Georgiou G. Rapid construction and characterization of synthetic antibody libraries without DNA amplification. Biotechnology and Bioengineering. 106: 347-57. PMID 20198660 DOI: 10.1002/Bit.22712  0.496
2010 Jung ST, Reddy ST, Kang TH, Borrok MJ, Sandlie I, Tucker PW, Georgiou G. Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 604-9. PMID 20080725 DOI: 10.1073/Pnas.0908590107  0.815
2010 Georgiou G, Shuler ML, Wilson DB. Release of periplasmic enzymes and other physiological effects of beta-lactamase overproduction in Escherichia coli. Biotechnology and Bioengineering. 32: 741-8. PMID 18587779 DOI: 10.1002/Bit.260320603  0.499
2010 Koulieris E, Kyrtsonis M, Maltezas D, Tzenou T, Mirbahai L, Kafassi N, Bartzis V, Dimou M, Georgiou G, Matsouka C, Pangalis G, Panayiotidis P, Bradwell A, Harding S. Quantification of Serum IgMκ and IgMλ In Patients with Waldenstrom's Macroglobulinemia (WM) at Diagnosis and During Disease Course; Clinical Correlations Blood. 116: 3004-3004. DOI: 10.1182/Blood.V116.21.3004.3004  0.31
2009 Varadarajan N, Pogson M, Georgiou G, Iverson BL. Proteases that can distinguish among different post-translational forms of tyrosine engineered using multicolor flow cytometry. Journal of the American Chemical Society. 131: 18186-90. PMID 19924991 DOI: 10.1021/Ja907803K  0.347
2009 Cantor JR, Stone EM, Chantranupong L, Georgiou G. The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity. Biochemistry. 48: 11026-31. PMID 19839645 DOI: 10.1021/Bi901397H  0.32
2009 Skretas G, Carroll S, DeFrees S, Schwartz MF, Johnson KF, Georgiou G. Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli. Microbial Cell Factories. 8: 50. PMID 19788761 DOI: 10.1186/1475-2859-8-50  0.622
2009 Zhou L, Zhao M, Wolf RZ, Graham DE, Georgiou G. Transcriptional regulation of the Escherichia coli gene rraB, encoding a protein inhibitor of RNase E Journal of Bacteriology. 191: 6665-6674. PMID 19717586 DOI: 10.1128/Jb.00344-09  0.355
2009 Pogson M, Georgiou G, Iverson BL. Engineering next generation proteases. Current Opinion in Biotechnology. 20: 390-7. PMID 19709875 DOI: 10.1016/J.Copbio.2009.07.003  0.313
2009 Arredondo SA, Chen TF, Riggs AF, Gilbert HF, Georgiou G. Role of dimerization in the catalytic properties of the Escherichia coli disulfide isomerase DsbC. The Journal of Biological Chemistry. 284: 23972-9. PMID 19581640 DOI: 10.1074/Jbc.M109.010199  0.758
2009 Varadarajan N, Cantor JR, Georgiou G, Iverson BL. Construction and flow cytometric screening of targeted enzyme libraries. Nature Protocols. 4: 893-901. PMID 19478805 DOI: 10.1038/Nprot.2009.60  0.36
2009 Leysath CE, Monzingo AF, Maynard JA, Barnett J, Georgiou G, Iverson BL, Robertus JD. Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen. Journal of Molecular Biology. 387: 680-93. PMID 19361425 DOI: 10.1016/J.Jmb.2009.02.003  0.636
2009 Mazor Y, Van Blarcom T, Iverson BL, Georgiou G. Isolation of full-length IgG antibodies from combinatorial libraries expressed in Escherichia coli. Methods in Molecular Biology (Clifton, N.J.). 525: 217-39, xiv. PMID 19252859 DOI: 10.1007/978-1-59745-554-1_11  0.783
2009 Seo MJ, Jeong KJ, Leysath CE, Ellington AD, Iverson BL, Georgiou G. Engineering antibody fragments to fold in the absence of disulfide bonds. Protein Science : a Publication of the Protein Society. 18: 259-67. PMID 19177559 DOI: 10.1002/Pro.31  0.609
2009 Eser M, Masip L, Kadokura H, Georgiou G, Beckwith J. Disulfide bond formation by exported glutaredoxin indicates glutathione's presence in the E. coli periplasm. Proceedings of the National Academy of Sciences of the United States of America. 106: 1572-7. PMID 19164554 DOI: 10.1073/Pnas.0812596106  0.732
2009 Skretas G, Georgiou G. Genetic analysis of G protein-coupled receptor expression in Escherichia Coli: Inhibitory role of DnaJ on the membrane integration of the human central cannabinoid receptor Biotechnology and Bioengineering. 102: 357-367. PMID 18828176 DOI: 10.1002/Bit.22097  0.38
2009 Strauch EM, Georgiou G. Mechanistic challenges and engineering applications of protein export in E. coli Systems Biology and Biotechnology of Escherichia Coli. 327-349. DOI: 10.1007/978-1-4020-9394-4_16  0.576
2008 Mazor Y, Van Blarcom T, Iverson BL, Georgiou G. E-clonal antibodies: selection of full-length IgG antibodies using bacterial periplasmic display. Nature Protocols. 3: 1766-77. PMID 18948976 DOI: 10.1038/Nprot.2008.176  0.779
2008 Skretas G, Georgiou G. Engineering G protein-coupled receptor expression in bacteria Proceedings of the National Academy of Sciences of the United States of America. 105: 14747-14748. PMID 18812517 DOI: 10.1073/Pnas.0807741105  0.305
2008 Arredondo S, Segatori L, Gilbert HF, Georgiou G. De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC. The Journal of Biological Chemistry. 283: 31469-76. PMID 18782764 DOI: 10.1074/Jbc.M803346200  0.804
2008 Varadarajan N, Georgiou G, Iverson BL. An engineered protease that cleaves specifically after sulfated tyrosine. Angewandte Chemie (International Ed. in English). 47: 7861-3. PMID 18780393 DOI: 10.1002/Anie.200800736  0.388
2008 Link AJ, Skretas G, Strauch EM, Chari NS, Georgiou G. Efficient production of membrane-integrated and detergent-soluble G protein-coupled receptors in Escherichia coli. Protein Science : a Publication of the Protein Society. 17: 1857-63. PMID 18593817 DOI: 10.1110/Ps.035980.108  0.703
2008 Faulkner MJ, Veeravalli K, Gon S, Georgiou G, Beckwith J. Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 6735-40. PMID 18456836 DOI: 10.1073/Pnas.0801986105  0.344
2008 Cobaugh CW, Almagro JC, Pogson M, Iverson B, Georgiou G. Synthetic Antibody Libraries Focused Towards Peptide Ligands Journal of Molecular Biology. 378: 622-633. PMID 18384812 DOI: 10.1016/J.Jmb.2008.02.037  0.402
2008 Li HX, Hwang BY, Laxmikanthan G, Blaber SI, Blaber M, Golubkov PA, Ren P, Iverson BL, Georgiou G. Substrate specificity of human kallikreins 1 and 6 determined by phage display. Protein Science : a Publication of the Protein Society. 17: 664-72. PMID 18359858 DOI: 10.1110/Ps.073333208  0.325
2008 Masip L, Klein-Marcuschamer D, Quan S, Bardwell JC, Georgiou G. Laboratory evolution of Escherichia coli thioredoxin for enhanced catalysis of protein oxidation in the periplasm reveals a phylogenetically conserved substrate specificity determinant. The Journal of Biological Chemistry. 283: 840-8. PMID 18003618 DOI: 10.1074/Jbc.M705147200  0.74
2008 Van Blarcom TJ, Carroll S, Mazor Y, Georgiou G. A comparison of antibodies isolated from immune libraries by two different Anchored Periplasmic Expression (APEx) systems Aiche Annual Meeting, Conference Proceedings 0.735
2007 Strauch EM, Georgiou G. Escherichia coli tatC mutations that suppress defective twin-arginine transporter signal peptides. Journal of Molecular Biology. 374: 283-91. PMID 17936785 DOI: 10.1016/J.Jmb.2007.09.050  0.608
2007 Link AJ, Jeong KJ, Georgiou G. Beyond toothpicks: new methods for isolating mutant bacteria. Nature Reviews. Microbiology. 5: 680-8. PMID 17676054 DOI: 10.1038/Nrmicro1715  0.527
2007 Jung ST, Jeong KJ, Iverson BL, Georgiou G. Binding and enrichment of Escherichia coli spheroplasts expressing inner membrane tethered scFv antibodies on surface immobilized antigens. Biotechnology and Bioengineering. 98: 39-47. PMID 17657772 DOI: 10.1002/Bit.21405  0.747
2007 Jeong KJ, Seo MJ, Iverson BL, Georgiou G. APEx 2-hybrid, a quantitative protein-protein interaction assay for antibody discovery and engineering. Proceedings of the National Academy of Sciences of the United States of America. 104: 8247-52. PMID 17494738 DOI: 10.1073/Pnas.0702650104  0.462
2007 Ribnicky B, Van Blarcom T, Georgiou G. A scFv Antibody Mutant Isolated in a Genetic Screen for Improved Export via the Twin Arginine Transporter Pathway Exhibits Faster Folding Journal of Molecular Biology. 369: 631-639. PMID 17462668 DOI: 10.1016/J.Jmb.2007.03.068  0.794
2007 Rouhier N, Unno H, Bandyopadhyay S, Masip L, Kim SK, Hirasawa M, Gualberto JM, Lattard V, Kusunoki M, Knaff DB, Georgiou G, Hase T, Johnson MK, Jacquot JP. Functional, structural, and spectroscopic characterization of a glutathione-ligated [2Fe-2S] cluster in poplar glutaredoxin C1. Proceedings of the National Academy of Sciences of the United States of America. 104: 7379-84. PMID 17460036 DOI: 10.1073/Pnas.0702268104  0.713
2007 Strauch EM, Georgiou G. A bacterial two-hybrid system based on the twin-arginine transporter pathway of E. coli. Protein Science : a Publication of the Protein Society. 16: 1001-8. PMID 17456749 DOI: 10.1110/Ps.062687207  0.64
2007 Mazor Y, Van Blarcom T, Mabry R, Iverson BL, Georgiou G. Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli. Nature Biotechnology. 25: 563-5. PMID 17435747 DOI: 10.1038/Nbt1296  0.781
2007 Levy R, Molineux IJ, Iverson BL, Georgiou G. Isolation of trans-acting genes that enhance soluble expression of scFv antibodies in the E. coli cytoplasm by lambda phage display. Journal of Immunological Methods. 321: 164-73. PMID 17328908 DOI: 10.1016/J.Jim.2007.01.017  0.615
2007 Tullman-Ercek D, DeLisa MP, Kawarasaki Y, Iranpour P, Ribnicky B, Palmer T, Georgiou G. Export pathway selectivity of Escherichia coli twin arginine translocation signal peptides. The Journal of Biological Chemistry. 282: 8309-16. PMID 17218314 DOI: 10.1074/Jbc.M610507200  0.77
2007 Link AJ, Georgiou G. Advances and challenges in membrane protein expression Aiche Journal. 53: 752-756. DOI: 10.1002/Aic.11107  0.521
2006 Griswold KE, Aiyappan NS, Iverson BL, Georgiou G. The evolution of catalytic efficiency and substrate promiscuity in human theta class 1-1 glutathione transferase. Journal of Molecular Biology. 364: 400-10. PMID 17011574 DOI: 10.1016/J.Jmb.2006.09.012  0.321
2006 Gao J, Lee K, Zhao M, Qiu J, Zhan X, Saxena A, Moore CJ, Cohen SN, Georgiou G. Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome Molecular Microbiology. 61: 394-406. PMID 16771842 DOI: 10.1111/J.1365-2958.2006.05246.X  0.705
2006 Masip L, Veeravalli K, Georgiou G. The many faces of glutathione in bacteria. Antioxidants & Redox Signaling. 8: 753-62. PMID 16771667 DOI: 10.1089/Ars.2006.8.753  0.724
2006 Lee PA, Tullman-Ercek D, Georgiou G. The bacterial twin-arginine translocation pathway. Annual Review of Microbiology. 60: 373-95. PMID 16756481 DOI: 10.1146/Annurev.Micro.60.080805.142212  0.674
2006 Zhao M, Zhou L, Kawarasaki Y, Georgiou G. Regulation of RraA, a protein inhibitor of RNase E-mediated RNA decay. Journal of Bacteriology. 188: 3257-63. PMID 16621818 DOI: 10.1128/Jb.188.9.3257-3263.2006  0.312
2006 Harvey BR, Shanafelt AB, Baburina I, Hui R, Vitone S, Iverson BL, Georgiou G. Engineering of recombinant antibody fragments to methamphetamine by anchored periplasmic expression. Journal of Immunological Methods. 308: 43-52. PMID 16337958 DOI: 10.1016/J.Jim.2005.09.017  0.406
2006 Segatori L, Murphy L, Arredondo S, Kadokura H, Gilbert H, Beckwith J, Georgiou G. Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB. The Journal of Biological Chemistry. 281: 4911-9. PMID 16280324 DOI: 10.1074/Jbc.M505453200  0.793
2006 Link AJ, Jeong K, Georgiou G. Expression of soluble and membrane proteins in E. coli Microbial Cell Factories. 5: 1-1. DOI: 10.1186/1475-2859-5-S1-S15  0.538
2005 Jeong KJ, Mabry R, Georgiou G. Avimers hold their own Nature Biotechnology.. 23: 1493-1494. PMID 16333289 DOI: 10.1038/Nbt1205-1493  0.388
2005 Mabry R, Rani M, Geiger R, Hubbard GB, Carrion R, Brasky K, Patterson JL, Georgiou G, Iverson BL. Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region. Infection and Immunity. 73: 8362-8. PMID 16299334 DOI: 10.1128/Iai.73.12.8362-8368.2005  0.402
2005 Georgiou G, Segatori L. Preparative expression of secreted proteins in bacteria: status report and future prospects. Current Opinion in Biotechnology. 16: 538-45. PMID 16095898 DOI: 10.1016/J.Copbio.2005.07.008  0.698
2005 Sheoran AS, Chapman-Bonofiglio S, Harvey BR, Mukherjee J, Georgiou G, Donohue-Rolfe A, Tzipori S. Human antibody against shiga toxin 2 administered to piglets after the onset of diarrhea due to Escherichia coli O157:H7 prevents fatal systemic complications. Infection and Immunity. 73: 4607-13. PMID 16040972 DOI: 10.1128/Iai.73.8.4607-4613.2005  0.355
2005 Griswold KE, Kawarasaki Y, Ghoneim N, Benkovic SJ, Iverson BL, Georgiou G. Evolution of highly active enzymes by homology-independent recombination. Proceedings of the National Academy of Sciences of the United States of America. 102: 10082-7. PMID 16009931 DOI: 10.1073/Pnas.0504556102  0.317
2005 Drummond DA, Iverson BL, Georgiou G, Arnold FH. Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins. Journal of Molecular Biology. 350: 806-16. PMID 15939434 DOI: 10.1016/J.Jmb.2005.05.023  0.484
2005 Varadarajan N, Gam J, Olsen MJ, Georgiou G, Iverson BL. Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity. Proceedings of the National Academy of Sciences of the United States of America. 102: 6855-60. PMID 15867160 DOI: 10.1073/Pnas.0500063102  0.335
2005 Hicks MG, Lee PA, Georgiou G, Berks BC, Palmer T. Positive selection for loss-of-function tat mutations identifies critical residues required for TatA activity. Journal of Bacteriology. 187: 2920-5. PMID 15805540 DOI: 10.1128/Jb.187.8.2920-2925.2005  0.321
2005 Goldman ER, Medintz IL, Hayhurst A, Anderson GP, Mauro JM, Iverson BL, Georgiou G, Mattoussi H. Self-assembled luminescent CdSe-ZnS quantum dot bioconjugates prepared using engineered poly-histidine terminated proteins Analytica Chimica Acta. 534: 63-67. DOI: 10.1016/J.Aca.2004.03.079  0.305
2004 Zhang M, Monzingo AF, Segatori L, Georgiou G, Robertus JD. Structure of DsbC from Haemophilus influenzae. Acta Crystallographica. Section D, Biological Crystallography. 60: 1512-8. PMID 15333920 DOI: 10.1107/S0907444904014593  0.688
2004 Ki JJ, Kawarasaki Y, Gam J, Harvey BR, Iverson BL, Georgiou G. A periplasmic fluorescent reporter protein and its application in high-throughput membrane protein topology analysis. Journal of Molecular Biology. 341: 901-9. PMID 15328603 DOI: 10.1016/J.Jmb.2004.05.078  0.358
2004 McCarter JD, Stephens D, Shoemaker K, Rosenberg S, Kirsch JF, Georgiou G. Substrate specificity of the Escherichia coli outer membrane protease OmpT. Journal of Bacteriology. 186: 5919-25. PMID 15317797 DOI: 10.1128/Jb.186.17.5919-5925.2004  0.338
2004 Segatori L, Paukstelis PJ, Gilbert HF, Georgiou G. Engineered DsbC chimeras catalyze both protein oxidation and disulfide-bond isomerization in Escherichia coli: Reconciling two competing pathways. Proceedings of the National Academy of Sciences of the United States of America. 101: 10018-23. PMID 15220477 DOI: 10.1073/Pnas.0403003101  0.7
2004 Harvey BR, Georgiou G, Hayhurst A, Jeong KJ, Iverson BL, Rogers GK. Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries. Proceedings of the National Academy of Sciences of the United States of America. 101: 9193-8. PMID 15197275 DOI: 10.1073/Pnas.0400187101  0.427
2004 Freeman A, Cohen-Hadar N, Abramov S, Modai-Hod R, Dror Y, Georgiou G. Screening of large protein libraries by the cell immobilized on adsorbed bead approach. Biotechnology and Bioengineering. 86: 196-200. PMID 15052639 DOI: 10.1002/Bit.10883  0.303
2004 Masip L, Pan JL, Haldar S, Penner-Hahn JE, DeLisa MP, Georgiou G, Bardwell JC, Collet JF. An engineered pathway for the formation of protein disulfide bonds. Science (New York, N.Y.). 303: 1185-9. PMID 14976313 DOI: 10.1126/Science.1092612  0.787
2004 Zhan X, Gao J, Jain C, Cieslewicz MJ, Swartz JR, Georgiou G. Genetic analysis of disulfide isomerization in Escherichia coli: expression of DsbC is modulated by RNase E-dependent mRNA processing. Journal of Bacteriology. 186: 654-60. PMID 14729690 DOI: 10.1128/Jb.186.3.654-660.2004  0.681
2004 DeLisa MP, Lee P, Palmer T, Georgiou G. Phage shock protein PspA of Escherichia coli relieves saturation of protein export via the Tat pathway. Journal of Bacteriology. 186: 366-73. PMID 14702305 DOI: 10.1128/Jb.186.2.366-373.2004  0.622
2003 Monzingo AF, Gao J, Qiu J, Georgiou G, Robertus JD. The X-ray structure of Escherichia coli RraA (MenG), A protein inhibitor of RNA processing. Journal of Molecular Biology. 332: 1015-24. PMID 14499605 DOI: 10.1016/S0022-2836(03)00970-7  0.642
2003 Lee K, Zhan X, Gao J, Qiu J, Feng Y, Meganathan R, Cohen SN, Georgiou G. RraA. a protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli. Cell. 114: 623-34. PMID 13678585 DOI: 10.1016/J.Cell.2003.08.003  0.707
2003 Goldman ER, Hayhurst A, Lingerfelt BM, Iverson BL, Georgiou G, Anderson GP. 2,4,6-Trinitrotoluene detection using recombinant antibodies. Journal of Environmental Monitoring : Jem. 5: 380-3. PMID 12833979 DOI: 10.1039/B302012F  0.408
2003 Lafond R, Zhan X, Georgiou G. Screening and selection strategies for disulfide isomerase activity. Methods in Molecular Biology (Clifton, N.J.). 230: 239-57. PMID 12824588 DOI: 10.1385/1-59259-396-8:239  0.459
2003 Hayhurst A, Happe S, Mabry R, Koch Z, Iverson BL, Georgiou G. Isolation and expression of recombinant antibody fragments to the biological warfare pathogen Brucella melitensis. Journal of Immunological Methods. 276: 185-96. PMID 12738372 DOI: 10.1016/S0022-1759(03)00100-5  0.434
2003 DeLisa MP, Tullman D, Georgiou G. Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway. Proceedings of the National Academy of Sciences of the United States of America. 100: 6115-20. PMID 12721369 DOI: 10.1073/Pnas.0937838100  0.628
2003 Georgiou G, Masip L. Biochemistry. An overoxidation journey with a return ticket. Science (New York, N.Y.). 300: 592-4. PMID 12714731 DOI: 10.1126/Science.1084976  0.696
2003 Griswold KE, Mahmood NA, Iverson BL, Georgiou G. Effects of codon usage versus putative 5'-mRNA structure on the expression of Fusarium solani cutinase in the Escherichia coli cytoplasm. Protein Expression and Purification. 27: 134-42. PMID 12509995 DOI: 10.1016/S1046-5928(02)00578-8  0.326
2003 Georgiou G. How to flip the (redox) switch. Cell. 111: 607-10. PMID 12464172 DOI: 10.1016/S0092-8674(02)01165-0  0.307
2002 Cox JC, Hayhurst A, Hesselberth J, Bayer TS, Georgiou G, Ellington AD. Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer. Nucleic Acids Research. 30: e108. PMID 12384610 DOI: 10.1093/Nar/Gnf107  0.502
2002 Chen W, Georgiou G. Cell-Surface display of heterologous proteins: From high-throughput screening to environmental applications. Biotechnology and Bioengineering. 79: 496-503. PMID 12209821 DOI: 10.1002/Bit.10407  0.374
2002 Maynard JA, Maassen CB, Leppla SH, Brasky K, Patterson JL, Iverson BL, Georgiou G. Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. Nature Biotechnology. 20: 597-601. PMID 12042864 DOI: 10.1038/Nbt0602-597  0.629
2002 DeLisa MP, Samuelson P, Palmer T, Georgiou G. Genetic analysis of the twin arginine translocator secretion pathway in bacteria. The Journal of Biological Chemistry. 277: 29825-31. PMID 12021272 DOI: 10.1074/Jbc.M201956200  0.623
2002 Maynard JA, Chen G, Georgiou G, Iverson BL. In vitro scanning-saturation mutagenesis. Methods in Molecular Biology (Clifton, N.J.). 182: 149-63. PMID 11768962 DOI: 10.1385/1-59259-194-9:149  0.528
2002 Hayhurst A, Georgiou G. High-throughput antibody isolation. Current Opinion in Chemical Biology. 5: 683-9. PMID 11738179 DOI: 10.1016/S1367-5931(01)00266-6  0.403
2001 Levy R, Weiss R, Chen G, Iverson BL, Georgiou G. Production of correctly folded Fab antibody fragment in the cytoplasm of Escherichia coli trxB gor mutants via the coexpression of molecular chaperones. Protein Expression and Purification. 23: 338-47. PMID 11676610 DOI: 10.1006/Prep.2001.1520  0.622
2001 Chen G, Hayhurst A, Thomas JG, Harvey BR, Iverson BL, Georgiou G. Isolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS). Nature Biotechnology. 19: 537-42. PMID 11385457 DOI: 10.1038/89281  0.367
2001 Bessette PH, Qiu J, Bardwell JC, Swartz JR, Georgiou G. Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli. Journal of Bacteriology. 183: 980-8. PMID 11208797 DOI: 10.1128/Jb.183.3.980-988.2001  0.751
2000 Olsen MJ, Stephens D, Griffiths D, Daugherty P, Georgiou G, Iverson BL. Function-based isolation of novel enzymes from a large library. Nature Biotechnology. 18: 1071-4. PMID 11017045 DOI: 10.1038/80267  0.364
2000 Daugherty PS, Iverson BL, Georgiou G. Flow cytometric screening of cell-based libraries. Journal of Immunological Methods. 243: 211-27. PMID 10986416 DOI: 10.1016/S0022-1759(00)00236-2  0.317
2000 Olsen M, Iverson B, Georgiou G. High-throughput screening of enzyme libraries Current Opinion in Biotechnology. 11: 331-337. PMID 10975452 DOI: 10.1016/S0958-1669(00)00108-7  0.328
2000 Daugherty PS, Chen G, Iverson BL, Georgiou G. Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies. Proceedings of the National Academy of Sciences of the United States of America. 97: 2029-34. PMID 10688877 DOI: 10.1073/Pnas.030527597  0.36
1999 Zhan X, Schwaller M, Gilbert HF, Georgiou G. Facilitating the formation of disulfide bonds in the Escherichia coli periplasm via coexpression of yeast protein disulfide isomerase. Biotechnology Progress. 15: 1033-8. PMID 10585186 DOI: 10.1021/Bp990083R  0.594
1999 Bessette PH, Aslund F, Beckwith J, Georgiou G. Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm. Proceedings of the National Academy of Sciences of the United States of America. 96: 13703-8. PMID 10570136 DOI: 10.1073/Pnas.96.24.13703  0.696
1999 Georgiou G, Valax P. Isolating inclusion bodies from bacteria. Methods in Enzymology. 309: 48-58. PMID 10507015 DOI: 10.1016/S0076-6879(99)09005-9  0.353
1999 Daugherty PS, Olsen MJ, Iverson BL, Georgiou G. Development of an optimized expression system for the screening of antibody libraries displayed on the Escherichia coli surface. Protein Engineering. 12: 613-21. PMID 10436088 DOI: 10.1093/Protein/12.7.613  0.373
1999 Chen G, Dubrawsky I, Mendez P, Georgiou G, Iverson BL. In vitro scanning saturation mutagenesis of all the specificity determining residues in an antibody binding site. Protein Engineering. 12: 349-56. PMID 10325406 DOI: 10.1093/Protein/12.4.349  0.405
1999 Park SJ, Georgiou G, Lee SY. Secretory production of recombinant protein by a high cell density culture of a protease negative mutant Escherichia coli strain. Biotechnology Progress. 15: 164-7. PMID 10194390 DOI: 10.1021/Bp9900108  0.318
1999 Freeman A, Abramov S, Georgiou G. Site-protected fixation and immobilization of Escherichia coli cells displaying surface-anchored beta-lactamase. Biotechnology and Bioengineering. 62: 155-9. PMID 10099524 DOI: 10.1002/(Sici)1097-0290(19990120)62:2<155::Aid-Bit4>3.0.Co;2-U  0.338
1999 Bessette PH, Cotto JJ, Gilbert HF, Georgiou G. In vivo and in vitro function of the Escherichia coli periplasmic cysteine oxidoreductase DsbG. The Journal of Biological Chemistry. 274: 7784-92. PMID 10075670 DOI: 10.1074/jbc.274.12.7784  0.684
1998 Qiu J, Swartz JR, Georgiou G. Expression of active human tissue-type plasminogen activator in Escherichia coli. Applied and Environmental Microbiology. 64: 4891-6. PMID 9835579 DOI: 10.1128/Aem.64.12.4891-4896.1998  0.586
1998 Daugherty PS, Chen G, Olsen MJ, Iverson BL, Georgiou G. Antibody affinity maturation using bacterial surface display. Protein Engineering. 11: 825-32. PMID 9796833 DOI: 10.1093/Protein/11.9.825  0.414
1997 Rietsch A, Bessette P, Georgiou G, Beckwith J. Reduction of the periplasmic disulfide bond isomerase, DsbC, occurs by passage of electrons from cytoplasmic thioredoxin Journal of Bacteriology. 179: 6602-6608. PMID 9352906 DOI: 10.1128/Jb.179.21.6602-6608.1997  0.691
1997 Georgiou G, Stathopoulos C, Daugherty PS, Nayak AR, Iverson BL, Curtiss R. Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines. Nature Biotechnology. 15: 29-34. PMID 9035102 DOI: 10.1038/Nbt0197-29  0.396
1997 Burks EA, Chen G, Georgiou G, Iverson BL. In vitro scanning saturation mutagenesis of an antibody binding pocket. Proceedings of the National Academy of Sciences of the United States of America. 94: 412-7. PMID 9012796 DOI: 10.1073/Pnas.94.2.412  0.434
1996 Georgiou G, Stephens DL, Stathopoulos C, Poetschke HL, Mendenhall J, Earhart CF. Display of β-lactamase on the Escherichia coli surface: Outer membrane phenotypes conferred by Lpp′-OmpA′-β-lactamase fusions Protein Engineering. 9: 239-247. PMID 9005446 DOI: 10.1093/Protein/9.2.239  0.364
1996 Chen G, Cloud J, Georgiou G, Iverson BL. A quantitative immunoassay utilizing Escherichia coli cells possessing surface-expressed single chain Fv molecules. Biotechnology Progress. 12: 572-4. PMID 8987483 DOI: 10.1021/Bp960041S  0.42
1996 Stathopoulos C, Georgiou G, Earhart CF. Characterization of Escherichia coli expressing an Lpp′OmpA(46-159)-PhoA fusion protein localized in the outer membrane Applied Microbiology and Biotechnology. 45: 112-119. PMID 8920186 DOI: 10.1007/S002530050657  0.4
1996 Georgiou G, Valax P. Expression of correctly folded proteins in Escherichia coli. Current Opinion in Biotechnology. 7: 190-7. PMID 8791338 DOI: 10.1016/S0958-1669(96)80012-7  0.396
1996 Ostermeier M, De Sutter K, Georgiou G. Eukaryotic protein disulfide isomerase complements Escherichia coli dsbA mutants and increases the yield of a heterologous secreted protein with disulfide bonds. The Journal of Biological Chemistry. 271: 10616-22. PMID 8631865 DOI: 10.1074/Jbc.271.18.10616  0.669
1996 Freeman A, Abramov S, Georgiou G. Communication fixation and stabilization of Escherichia coli cells displaying genetically engineered cell surface proteins Biotechnology and Bioengineering. 52: 625-630. DOI: 10.1002/(Sici)1097-0290(19961205)52:5<625::Aid-Bit10>3.3.Co;2-O  0.308
1995 Francisco JA, Georgiou G. The expression of recombinant proteins on the external surface of Escherichia coli. Biotechnological applications. Annals of the New York Academy of Sciences. 745: 372-82. PMID 7832524 DOI: 10.1111/J.1749-6632.1994.Tb44389.X  0.414
1995 Meerman HJ, Georgiou G. Construction and characterization of a set of E. coli strains deficient in all known loci affecting the proteolytic stability of secreted recombinant proteins. Bio/Technology (Nature Publishing Company). 12: 1107-10. PMID 7765553 DOI: 10.1038/Nbt1194-1107  0.371
1994 Lin SC, Minton MA, Sharma MM, Georgiou G. Structural and immunological characterization of a biosurfactant produced by Bacillus licheniformis JF-2. Applied and Environmental Microbiology. 60: 31-8. PMID 8117083 DOI: 10.1128/Aem.60.1.31-38.1994  0.321
1994 Georgiou G, Valax P, Ostermeier M, Horowitz PM. Folding and aggregation of TEM beta-lactamase: analogies with the formation of inclusion bodies in Escherichia coli. Protein Science : a Publication of the Protein Society. 3: 1953-60. PMID 7703842 DOI: 10.1002/Pro.5560031107  0.614
1993 Francisco JA, Campbell R, Iverson BL, Georgiou G. Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface. Proceedings of the National Academy of Sciences of the United States of America. 90: 10444-8. PMID 8248129 DOI: 10.1073/Pnas.90.22.10444  0.433
1993 Francisco JA, Stathopoulos C, Warren RA, Kilburn DG, Georgiou G. Specific adhesion and hydrolysis of cellulose by intact Escherichia coli expressing surface anchored cellulase or cellulose binding domains. Bio/Technology (Nature Publishing Company). 11: 491-5. PMID 7763519 DOI: 10.1038/Nbt0493-491  0.372
1993 Georgiou G, Poetschke HL, Stathopoulos C, Francisco JA. Practical applications of engineering Gram-negative bacterial cell surfaces Trends in Biotechnology. 11: 6-10. PMID 7763382 DOI: 10.1016/0167-7799(93)90068-K  0.344
1992 Phelps PA, Agarwal SK, Speitel GE, Georgiou G. Methylosinus trichosporium OB3b Mutants Having Constitutive Expression of Soluble Methane Monooxygenase in the Presence of High Levels of Copper Applied and Environmental Microbiology. 58: 3701-3708. PMID 16348810 DOI: 10.1128/Aem.58.11.3701-3708.1992  0.322
1992 Francisco JA, Earhart CF, Georgiou G. Transport and anchoring of beta-lactamase to the external surface of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 89: 2713-7. PMID 1557377 DOI: 10.1073/Pnas.89.7.2713  0.343
1992 Baneyx F, Georgiou G. Degradation of secreted proteins in Escherichia coli. Annals of the New York Academy of Sciences. 665: 301-8. PMID 1416612 DOI: 10.1111/J.1749-6632.1992.Tb42593.X  0.347
1991 Baneyx F, Georgiou G. Construction and characterization of Escherichia coli strains deficient in multiple secreted proteases: protease III degrades high-molecular-weight substrates in vivo. Journal of Bacteriology. 173: 2696-703. PMID 2013581 DOI: 10.1128/Jb.173.8.2696-2703.1991  0.336
1991 Baneyx F, Ayling A, Palumbo T, Thomas D, Georgiou G. Optimization of growth conditions for the production of proteolytically-sensitive proteins in the periplasmic space of Escherichia coli. Applied Microbiology and Biotechnology. 36: 14-20. PMID 1367774 DOI: 10.1007/Bf00164691  0.357
1991 Bowden GA, Paredes AM, Georgiou G. Structure and morphology of protein inclusion bodies in Escherichia coli. Bio/Technology (Nature Publishing Company). 9: 725-30. PMID 1367632 DOI: 10.1038/Nbt0891-725  0.342
1990 Baneyx F, Georgiou G. In vivo degradation of secreted fusion proteins by the Escherichia coli outer membrane protease OmpT. Journal of Bacteriology. 172: 491-4. PMID 2403549 DOI: 10.1128/Jb.172.1.491-494.1990  0.36
1990 Georgiou G, Baneyx F. Expression, purification, and immobilization of a protein A-beta-lactamase hybrid protein. Annals of the New York Academy of Sciences. 589: 139-47. PMID 2192655 DOI: 10.1111/J.1749-6632.1990.Tb24240.X  0.307
1990 Baneyx F, Schmidt C, Georgiou G. Affinity immobilization of a genetically engineered bifunctional hybrid protein. Enzyme and Microbial Technology. 12: 337-42. PMID 1366486 DOI: 10.1016/0141-0229(90)90161-I  0.583
1989 Baneyx F, Georgiou G. Expression, purification, and enzymatic characterization of a protein A-β-lactamase hybrid protein Enzyme and Microbial Technology. 11: 559-567. DOI: 10.1016/0141-0229(89)90083-5  0.371
1988 Georgiou G, Palumbo T, Wilson DB, Shuler ML. Effect of alkaline medium on the production and excretion of B-lactamase by Escherichia coli Biotechnology Letters. 10: 377-382. DOI: 10.1007/Bf01087432  0.505
1986 Georgiou G, Telford JN, Shuler ML, Wilson DB. Localization of inclusion bodies in Escherichia coli overproducing β-lactamase or alkaline phosphatase Applied and Environmental Microbiology. 52: 1157-1161. PMID 3539017 DOI: 10.1128/Aem.52.5.1157-1161.1986  0.495
1985 Georgiou G, Chalmers JJ, Shuler ML, Wilson DB. Continuous Immobilized Recombinant Protein Production from E. coli Capable of Selective Protein Excretion: A Feasibility Study. Biotechnology Progress. 1: 75-9. PMID 20568139 DOI: 10.1002/Btpr.5420010114  0.675
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