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Kelli L. VanDussen, Ph.D. - Publications

Affiliations: 
2010 University of Michigan, Ann Arbor, Ann Arbor, MI 
 2018- Pediatrics Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States 
Area:
Physiology Biology, Human Development, Cell Biology
Website:
https://www.cincinnatichildrens.org/bio/v/kelli-vandussen
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ma C, Haritunians T, Gremida AK, Syal G, Shah J, Yang S, Ramos Del Aguila de Rivers C, Storer CE, Chen L, Mengesha E, Mujukian A, Hanna M, Fleshner P, Binion DG, VanDussen KL, et al. Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis. Journal of Crohn's & Colitis. PMID 38953127 DOI: 10.1093/ecco-jcc/jjae105  0.557
2023 Funkhouser-Jones LJ, Xu R, Wilke G, Fu Y, Schriefer LA, Makimaa H, Rodgers R, Kennedy EA, VanDussen KL, Stappenbeck TS, Baldridge MT, Sibley LD. Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth. Cell Reports. 42: 112680. PMID 37384526 DOI: 10.1016/j.celrep.2023.112680  0.482
2023 Funkhouser-Jones LJ, Xu R, Wilke G, Fu Y, Shriefer LA, Makimaa H, Rodgers R, Kennedy EA, VanDussen KL, Stappenbeck TS, Baldridge MT, Sibley LD. Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit growth. Biorxiv : the Preprint Server For Biology. PMID 37292732 DOI: 10.1101/2023.05.25.542157  0.502
2021 Ojo BA, VanDussen KL, Rosen MJ. The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis. Inflammatory Bowel Diseases. PMID 34251431 DOI: 10.1093/ibd/izab161  0.311
2021 Liu TC, Kern JT, Jain U, Sonnek NM, Xiong S, Simpson KF, VanDussen KL, Winkler ES, Haritunians T, Malique A, Lu Q, Sasaki Y, Storer C, Diamond MS, Head RD, et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host & Microbe. PMID 34010595 DOI: 10.1016/j.chom.2021.04.004  0.606
2020 VanDussen KL, Funkhouser-Jones LJ, Akey ME, Schaefer DA, Ackman K, Riggs MW, Stappenbeck TS, Sibley LD. Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells. Mbio. 11. PMID 33323514 DOI: 10.1128/mBio.02582-20  0.531
2020 Osterman MT, VanDussen KL, Gordon IO, Davis EM, Li K, Simpson K, Ciorba M, Glover SC, Abraham B, Guo X, Yee EU, Allard FD, Perrigoue JG, Claggett B, Shen B, et al. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflammatory Bowel Diseases. PMID 32964238 DOI: 10.1093/ibd/izaa251  0.572
2020 Seiler KM, Bajinting A, Alvarado DM, Traore MA, Binkley MM, Goo WH, Lanik WE, Ou J, Ismail U, Iticovici M, King CR, VanDussen KL, Swietlicki EA, Gazit V, Guo J, et al. Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Scientific Reports. 10: 3842. PMID 32123209 DOI: 10.1038/S41598-020-60672-5  0.618
2019 Wang Y, Chiang IL, Ohara TE, Fujii S, Cheng J, Muegge BD, Ver Heul A, Han ND, Lu Q, Xiong S, Chen F, Lai CW, Janova H, Wu R, Whitehurst CE, ... VanDussen KL, et al. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. PMID 31708126 DOI: 10.1016/J.Cell.2019.10.015  0.779
2019 Alvarado DM, Chen B, Iticovici M, Thaker AI, Dai N, VanDussen KL, Shaikh N, Lim CK, Guillemin GJ, Tarr PI, Ciorba MA. Epithelial IDO1 Modulates AHR and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota. Gastroenterology. PMID 31325428 DOI: 10.1053/J.Gastro.2019.07.013  0.465
2019 Wilke G, Funkhouser-Jones LJ, Wang Y, Ravindran S, Wang Q, Beatty WL, Baldridge MT, VanDussen KL, Shen B, Kuhlenschmidt MS, Kuhlenschmidt TB, Witola WH, Stappenbeck TS, Sibley LD. A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability. Cell Host & Microbe. PMID 31231046 DOI: 10.1016/J.Chom.2019.05.007  0.603
2019 VanDussen KL, Sonnek NM, Stappenbeck TS. L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams. Stem Cell Research. 37: 101430. PMID 30933720 DOI: 10.1016/J.Scr.2019.101430  0.549
2019 Potdar AA, Li D, Haritunians T, VanDussen KL, Fiorino MF, Liu TC, Stappenbeck TS, Fleshner P, Targan SR, McGovern DPB, Bilsborough J. Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Sub-Groups. Journal of Crohn's & Colitis. PMID 30877309 DOI: 10.1093/Ecco-Jcc/Jjz021  0.558
2019 Kaiko GE, Chen F, Lai CW, Chiang IL, Perrigoue J, Stojmirović A, Li K, Muegge BD, Jain U, VanDussen KL, Goggins BJ, Keely S, Weaver J, Foster PS, Lawrence DA, et al. PAI-1 augments mucosal damage in colitis. Science Translational Medicine. 11. PMID 30842312 DOI: 10.1126/Scitranslmed.Aat0852  0.755
2019 Alvarado DM, Santhanam S, Iticovici M, VanDussen K, Shaikh N, Chen B, Lim C, Guillemin G, Tarr PI, Ciorba MA. 11 EPITHELIAL IDO1 MODULATES AHR AND NOTCH SIGNALING TO ENHANCE SECRETORY CELL DIFFERENTIATION AND ALTERS MUCUS-ASSOCIATED MICROBIOTA Gastroenterology. 156: S84. DOI: 10.1053/J.Gastro.2019.01.195  0.431
2019 VanDussen KL, Liu T, Simpson KF, Ciorba MA, Haritunians T, Fleshner P, McGovern D, Head RD, Stappenbeck TS. Su1826 – Small Intestinal Epithelial Microvilli-Associated Defects Present in a Multi-Center Replication Cohort of Crohn’s Disease Patients Gastroenterology. 156: S-625. DOI: 10.1016/S0016-5085(19)38463-X  0.589
2019 Alvarado DM, Chen B, Iticovici M, VanDussen KL, Shaikh N, Lim CK, Guillemin G, Tarr PI, Ciorba MA. 422 – Epithelial Ido1 Modulates Ahr and Notch Signaling to Enhance Secretory Cell Differentiation, Augment Mucus Barrier, and Alter Microbiota Gastroenterology. 156: S-82. DOI: 10.1016/S0016-5085(19)36995-1  0.429
2018 Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS. Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease. The Journal of Clinical Investigation. PMID 30137026 DOI: 10.1172/Jci120453  0.594
2018 Jain U, Lai CW, Xiong S, Goodwin VM, Lu Q, Muegge BD, Christophi GP, VanDussen KL, Cummings BP, Young E, Hambor J, Stappenbeck TS. Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration. Cell Host & Microbe. PMID 30122655 DOI: 10.1016/J.Chom.2018.07.019  0.727
2018 Wilke G, Ravindran S, Funkhouser-Jones L, Barks J, Wang Q, VanDussen KL, Stappenbeck TS, Kuhlenschmidt TB, Kuhlenschmidt MS, Sibley LD. Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression . Msphere. 3. PMID 29848759 DOI: 10.1128/mSphere.00124-18  0.45
2018 VanDussen KL, Stojmirović A, Li K, Liu TC, Kimes PK, Muegge BD, Simpson KF, Ciorba MA, Perrigoue JG, Friedman JR, Towne JE, Head RD, Stappenbeck TS. Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. Gastroenterology. PMID 29782846 DOI: 10.1053/J.Gastro.2018.05.028  0.763
2018 VanDussen KL, Li K, Stojmirović A, Liu T-, Kimes PK, Perrigoue JG, Friedman JR, Towne JE, Head RD, Stappenbeck T. P050 Enterocyte microvillus length and associated gene expression are reduced in Crohn’s disease Journal of Crohn's and Colitis. 12: S117-S117. DOI: 10.1093/Ecco-Jcc/Jjx180.177  0.528
2018 VanDussen KL, Stojmirović A, Liu T, Kimes PK, Perrigoue JG, Friedman JR, Towne JE, Head RD, Stappenbeck TS. P066 INTESTINAL EPITHELIAL MICROVILLI ARE ABNORMAL IN CROHN'S DISEASE Gastroenterology. 154: S35. DOI: 10.1053/j.gastro.2017.11.104  0.552
2018 VanDussen KL, Stojmirović A, Liu T, Kimes PK, Perrigoue JG, Friedman JR, Towne JE, Head RD, Stappenbeck TS. P066 INTESTINAL EPITHELIAL MICROVILLI ARE ABNORMAL IN CROHN’S DISEASE Inflammatory Bowel Diseases. 24: S24-S25. DOI: 10.1053/J.Gastro.2017.11.104  0.594
2018 Liu T, Kern J, VanDussen KL, Xiong S, Caruso R, Nunez G, Head R, Stappenbeck TS. P063 INTERACTIONS OF GENETIC AND ENVIRONMENTAL FACTORS TRIGGER UNIQUE PPAR-GAMMA SIGNATURE IN PANETH CELLS IN CROHN’S DISEASE SUBJECTS AND RELEVANT MOUSE MODELS Gastroenterology. 154: S34. DOI: 10.1053/j.gastro.2017.11.101  0.505
2018 Liu T, Kern J, VanDussen KL, Xiong S, Caruso R, Nunez G, Head R, Stappenbeck TS. P063 INTERACTIONS OF GENETIC AND ENVIRONMENTAL FACTORS TRIGGER UNIQUE PPAR-GAMMA SIGNATURE IN PANETH CELLS IN CROHN’S DISEASE SUBJECTS AND RELEVANT MOUSE MODELS Inflammatory Bowel Diseases. 24: S24-S24. DOI: 10.1053/J.Gastro.2017.11.101  0.554
2018 Liu T, Kern J, VanDussen KL, Xiong S, Head R, Stappenbeck T. Su2030 - Farnesoid X Receptor Mediates Western Diet-Induced Paneth Cell Defects Gastroenterology. 154: S-1363. DOI: 10.1016/S0016-5085(18)34454-8  0.547
2018 Seiler K, Binkley M, Alvarado DM, Iticovici M, Goo W, VanDussen KL, Stappenbeck T, Rubin DC, George S, Ciorba MA, Meacham M, Warner BW. Tu1258 - Development of Patient-Derived “Small Intestine-On-A-Chip” Microfluidic Devices Gastroenterology. 154: S-917. DOI: 10.1016/S0016-5085(18)33084-1  0.537
2017 Liu TC, Naito T, Liu Z, VanDussen KL, Haritunians T, Li D, Endo K, Kawai Y, Nagasaki M, Kinouchi Y, McGovern DP, Shimosegawa T, Kakuta Y, Stappenbeck TS. LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients. Jci Insight. 2: e91917. PMID 28352666 DOI: 10.1172/Jci.Insight.91917  0.581
2017 Liu T, Naito T, Liu Z, VanDussen K, Haritunians T, Li D, Endo K, Kawai Y, Nagasaki M, Kinouchi Y, McGovern D, Shimosegawa T, Kakuta Y, Stappenbeck TS. Dichotomous Effects of ATG16L1 and LRRK2 in Modulating Paneth Cell Defect in Japanese and North American Crohn's Disease Patients Gastroenterology. 152: S982. DOI: 10.1016/S0016-5085(17)33325-5  0.584
2017 VanDussen KL, Liu T, Head R, Stappenbeck TS. RNA-SEQ of Formalin-Fixed, Paraffin-Embedded Intestinal Tissue Identifies an Epithelial Defect in crohn's Gastroenterology. 152: S565. DOI: 10.1016/S0016-5085(17)32044-9  0.554
2016 Miyoshi H, VanDussen KL, Malvin NP, Ryu SH, Wang Y, Sonnek NM, Lai CW, Stappenbeck TS. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. The Embo Journal. PMID 27797821 DOI: 10.15252/Embj.201694660  0.665
2016 VanDussen K, Miyoshi H, Sonnek N, Ciorba M, Stappenbeck T. O-013 Defining the Basis of Epithelial Defects in Crohnʼs Using Intestinal Spheroid Culture Inflammatory Bowel Diseases. 22: S1-S80. DOI: 10.1097/01.Mib.0000480099.17894.1F  0.555
2016 Liu T, VanDussen KL, Stappenbeck T. Sa1823 Vitamin D Receptor Affects Small Intestinal Paneth Cell Phenotype in Crohn's Disease Patients Independent of ATG16L1 Modulation Gastroenterology. 150: S373. DOI: 10.1016/S0016-5085(16)31312-9  0.601
2015 Demitrack ES, Gifford GB, Keeley TM, Carulli AJ, VanDussen KL, Thomas D, Giordano TJ, Liu Z, Kopan R, Samuelson LC. Notch signaling regulates gastric antral LGR5 stem cell function. The Embo Journal. PMID 26271103 DOI: 10.15252/Embj.201490583  0.638
2015 VanDussen KL, Marinshaw JM, Shaikh N, Miyoshi H, Moon C, Tarr PI, Ciorba MA, Stappenbeck TS. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut. 64: 911-20. PMID 25007816 DOI: 10.1136/Gutjnl-2013-306651  0.712
2014 Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ. ADAM10 regulates Notch function in intestinal stem cells of mice. Gastroenterology. 147: 822-834.e13. PMID 25038433 DOI: 10.1053/J.Gastro.2014.07.003  0.658
2014 Moon C, VanDussen KL, Miyoshi H, Stappenbeck TS. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal Immunology. 7: 818-28. PMID 24220295 DOI: 10.1038/Mi.2013.98  0.738
2014 VanDussen KL, Liu TC, Li D, Towfic F, Modiano N, Winter R, Haritunians T, Taylor KD, Dhall D, Targan SR, Xavier RJ, McGovern DP, Stappenbeck TS. Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology. 146: 200-9. PMID 24076061 DOI: 10.1053/J.Gastro.2013.09.048  0.623
2014 Haritunians T, Liu T, VanDussen KL, Li D, Stappenbeck TS, McGovern DP. 129 Genetic Variation Associated With Paneth Cell Morphological Changes in CD Gastroenterology. 146: S-36. DOI: 10.1016/S0016-5085(14)60124-4  0.526
2013 Liu T, VanDussen K, Gao F, Li D, Towfic F, Modiano N, Winter R, Haritunians T, Dhall D, Targan S, Xavier R, McGovern D, Stappenbeck T. O-025 Paneth Cell Phenotype Correlates with Genetics, Transcriptome Profile, Pathologic Hallmark and Predicts Clinical Outcome in Patients with Crohnʼs Disease Inflammatory Bowel Diseases. 19: S15. DOI: 10.1097/01.Mib.0000438994.14825.01  0.547
2013 VanDussen KL, Head R, Stappenbeck TS. Sa1816 RNA-Seq Analysis of Formalin-Fixed Paraffin-Embedded Intestinal Tissue Identifies a Gene Network Associated With Epithelial Dysregulation in Crohn's Disease Patients Gastroenterology. 144: S-312. DOI: 10.1016/S0016-5085(13)61126-9  0.565
2013 VanDussen KL, Marinshaw JM, Miyoshi H, Ciorba MA, Stappenbeck TS. 280 Efficient Isolation, Expansion and Differentiation of Human Epithelial Stem Cells From Endoscopic Biopsies of the Gastrointestinal Tract Gastroenterology. 144: S-62-S-63. DOI: 10.1016/S0016-5085(13)60226-7  0.606
2012 VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud A, Grosse AS, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ, et al. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells Development. 139: 488-497. PMID 22190634 DOI: 10.1242/Dev.070763  0.679
2011 Mendez MP, Monroy YK, Du M, Preston AM, Tolle L, Lin Y, VanDussen KL, Samuelson LC, Standiford TJ, Curtis JL, Beck JM, Christensen PJ, Paine R. Overexpression of sICAM-1 in the alveolar epithelial space results in an exaggerated inflammatory response and early death in Gram negative pneumonia. Respiratory Research. 12: 12. PMID 21247482 DOI: 10.1186/1465-9921-12-12  0.556
2011 Demitrack E, VanDussen KL, Samuelson LC. Notch Signaling is Critical for Gastric Epithelial Cell Homeostasis, Regulating Proliferation, Gastric Antral Stem Cell Marker Expression and Cell Lineage Determination Gastroenterology. 140: S-628. DOI: 10.1016/S0016-5085(11)62597-3  0.632
2011 Tsai Y, VanDussen KL, Bhatt R, Crawford HC, Samuelson LC, Dempsey PJ. ADAM10 is Essential for Intestinal Crypt Homeostasis Gastroenterology. 140: S-38. DOI: 10.1016/S0016-5085(11)60152-2  0.623
2010 VanDussen KL, Samuelson LC. Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Developmental Biology. 346: 215-23. PMID 20691176 DOI: 10.1016/J.Ydbio.2010.07.026  0.681
2010 Tsai Y, VanDussen KL, Crawford HC, Samuelson LC, Dempsey PJ. T1728 Role of ADAM10 Signaling in Cell Proliferation and Cell Fate Specification is Conserved Between the Developing and Adult Intestine Gastroenterology. 138: S-566. DOI: 10.1016/S0016-5085(10)62606-6  0.633
2010 VanDussen KL, Kolterud Å, Gumucio DL, Samuelson LC. 848 Notch Signaling Induces Expression of the Intestinal Stem Cell Marker Olfactomedin 4 (OLFM4) Gastroenterology. 138: S-116. DOI: 10.1016/S0016-5085(10)60531-8  0.645
2009 VanDussen KL, Samuelson LC. 865 Math1 Regulates Epithelial-Mesenchymal Crosstalk in the Intestine to Alter Mesenchymal Development and Hedgehog Signaling Gastroenterology. 136: A-132-A-133. DOI: 10.1016/S0016-5085(09)60594-1  0.627
2009 VanDussen KL, Stoeck A, Shang L, Crawford HC, Samuelson LC, Dempsey PJ. 277 Adam10 Is Required for Cell Lineage Specification of the Intestinal Epithelium Gastroenterology. 136: A-53-A-54. DOI: 10.1016/S0016-5085(09)60242-0  0.678
2008 VanDussen KL, Samuelson LC. 210 Math1 Directs Intestinal Secretory Cell Specification and Is a Novel Regulator of Epithelium-Mesenchyme Signaling Gastroenterology. 134: A-37. DOI: 10.1016/S0016-5085(08)60178-X  0.66
2007 López-Díaz L, Jain RN, Keeley TM, VanDussen KL, Brunkan CS, Gumucio DL, Samuelson LC. Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate Developmental Biology. 309: 298-305. PMID 17706959 DOI: 10.1016/J.Ydbio.2007.07.015  0.775
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