| Year |
Citation |
Score |
| 2023 |
Zhao F, Deng Y, Yang F, Yan Y, Feng F, Peng B, Gao J, Bedford MT, Li H. Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional attenuation. Journal of Molecular Biology. 168371. PMID 37977297 DOI: 10.1016/j.jmb.2023.168371 |
0.384 |
|
| 2023 |
Santos M, Hwang JW, Bedford MT. CARM1 Arginine Methyltransferase as a Therapeutic Target for Cancer. The Journal of Biological Chemistry. 105124. PMID 37536629 DOI: 10.1016/j.jbc.2023.105124 |
0.334 |
|
| 2023 |
Wang Y, Bedford MT. Effectors and effects of arginine methylation. Biochemical Society Transactions. 51: 725-734. PMID 37013969 DOI: 10.1042/BST20221147 |
0.429 |
|
| 2023 |
Gao G, Hausmann S, Flores NM, Benitez AM, Shen J, Yang X, Person MD, Gayatri S, Cheng D, Lu Y, Liu B, Mazur PK, Bedford MT. The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer. Nature Communications. 14: 363. PMID 36690626 DOI: 10.1038/s41467-023-35864-y |
0.434 |
|
| 2022 |
Horton JR, Zhou J, Chen Q, Zhang X, Bedford MT, Cheng X. A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. The Journal of Biological Chemistry. 102862. PMID 36596360 DOI: 10.1016/j.jbc.2022.102862 |
0.347 |
|
| 2022 |
Admoni-Elisha L, Elbaz T, Chopra A, Shapira G, Bedford MT, Fry CJ, Shomron N, Biggar K, Feldman M, Levy D. TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma. Nucleic Acids Research. PMID 35694846 DOI: 10.1093/nar/gkac485 |
0.377 |
|
| 2022 |
Iannelli G, Milite C, Marechal N, Cura V, Bonnefond L, Troffer-Charlier N, Feoli A, Rescigno D, Wang Y, Cipriano A, Viviano M, Bedford MT, Cavarelli J, Castellano S, Sbardella G. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. Journal of Medicinal Chemistry. PMID 35482954 DOI: 10.1021/acs.jmedchem.2c00252 |
0.319 |
|
| 2022 |
Van HT, Harkins PR, Patel A, Jain AK, Lu Y, Bedford MT, Santos MA. Methyl-lysine readers PHF20 and PHF20L1 define two distinct gene expression-regulating NSL complexes. The Journal of Biological Chemistry. 298: 101588. PMID 35033534 DOI: 10.1016/j.jbc.2022.101588 |
0.394 |
|
| 2021 |
Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, ... ... Bedford MT, et al. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chemical Biology. PMID 34715055 DOI: 10.1016/j.chembiol.2021.10.003 |
0.362 |
|
| 2021 |
Wang Y, Person MD, Bedford MT. Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens. Methods (San Diego, Calif.). PMID 34107353 DOI: 10.1016/j.ymeth.2021.06.005 |
0.317 |
|
| 2021 |
Chen J, Horton J, Sagum C, Zhou J, Cheng X, Bedford MT. Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. The Biochemical Journal. PMID 33969871 DOI: 10.1042/BCJ20210203 |
0.41 |
|
| 2020 |
Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Richard S, Bedford MT. Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. The Journal of Biological Chemistry. 295: 17060-17070. PMID 33453958 DOI: 10.1074/jbc.RA120.014704 |
0.312 |
|
| 2020 |
Vaughan RM, Kupai A, Foley CA, Sagum CA, Tibben BM, Eden HE, Tiedemann RL, Berryhill CA, Patel V, Shaw KM, Krajewski K, Strahl BD, Bedford MT, Frye SV, Dickson BM, et al. The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells. Epigenetics & Chromatin. 13: 44. PMID 33097091 DOI: 10.1186/s13072-020-00366-4 |
0.441 |
|
| 2020 |
Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Richard S, Bedford MT. Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. The Journal of Biological Chemistry. PMID 33008887 DOI: 10.1074/jbc.RA120.014704 |
0.309 |
|
| 2020 |
Shen Y, Gao G, Yu X, Kim HS, Wang L, Xie L, Schwarz M, Chen X, Guccione E, Liu J, Bedford MT, Jin J. Discovery of First-in-class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. Journal of Medicinal Chemistry. PMID 32787082 DOI: 10.1021/Acs.Jmedchem.0C01111 |
0.328 |
|
| 2020 |
Hwang JW, Kim SN, Myung N, Song D, Han G, Bae GU, Bedford MT, Kim YK. PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation. Communications Biology. 3: 428. PMID 32759981 DOI: 10.1038/s42003-020-01157-z |
0.319 |
|
| 2020 |
Woodcock CB, Horton JR, Zhou J, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Research. PMID 32663306 DOI: 10.1093/Nar/Gkaa604 |
0.418 |
|
| 2020 |
Veazey KJ, Cheng D, Lin K, Villarreal OD, Gao G, Perez-Oquendo M, Van HT, Stratton SA, Green M, Xu H, Lu Y, Bedford MT, Santos MA. CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas. Leukemia. PMID 32576962 DOI: 10.1038/S41375-020-0908-8 |
0.337 |
|
| 2020 |
Jain K, Fraser CS, Marunde MR, Parker MM, Sagum C, Burg JM, Hall N, Popova IK, Rodriguez KL, Vaidya A, Krajewski K, Keogh MC, Bedford MT, Strahl BD. Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions. Epigenetics & Chromatin. 13: 3. PMID 31980037 DOI: 10.1186/S13072-020-0328-Z |
0.531 |
|
| 2020 |
Stossi F, Dandekar RD, Mancini MG, Gu G, Fuqua SAW, Nardone A, De Angelis C, Fu X, Schiff R, Bedford MT, Xu W, Johansson HE, Stephan CC, Mancini MA. Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity. Nucleic Acids Research. PMID 31930333 DOI: 10.1093/Nar/Gkz1172 |
0.365 |
|
| 2020 |
Han Z, Dash S, Sagum CA, Ruthel G, Jaladanki CK, Berry CT, Schwoerer MP, Harty NM, Freedman BD, Bedford MT, Fan H, Sidhu SS, Sudol M, Shtanko O, Harty RN. Modular Mimicry and Engagement of the Hippo Pathway by Marburg Virus VP40: Implications for Filovirus Biology and Budding. Plos Pathogens. 16: e1008231. PMID 31905227 DOI: 10.1371/Journal.Ppat.1008231 |
0.33 |
|
| 2019 |
Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Kashyap TR, Fushman D, Cheng X, Bedford MT, Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes & Development. PMID 31699778 DOI: 10.1101/Gad.332395.119 |
0.374 |
|
| 2019 |
Manickavinayaham S, Vélez-Cruz R, Biswas AK, Bedford E, Klein BJ, Kutateladze TG, Liu B, Bedford MT, Johnson DG. E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. Nature Communications. 10: 4951. PMID 31666529 DOI: 10.1038/S41467-019-12861-8 |
0.32 |
|
| 2019 |
Chen J, Sagum C, Bedford MT. Protein Domain Microarrays as a Platform to Decipher Signaling Pathways and the Histone Code. Methods (San Diego, Calif.). PMID 31449908 DOI: 10.1016/J.Ymeth.2019.08.007 |
0.397 |
|
| 2019 |
Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, et al. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chemical Biology. PMID 31422906 DOI: 10.1016/J.Chembiol.2019.07.013 |
0.506 |
|
| 2019 |
Gao G, Zhang L, Villarreal OD, He W, Su D, Bedford E, Moh P, Shen J, Shi X, Bedford MT, Xu H. PRMT1 loss sensitizes cells to PRMT5 inhibition. Nucleic Acids Research. PMID 30916320 DOI: 10.1093/Nar/Gkz200 |
0.399 |
|
| 2019 |
Rajendran P, Johnson GS, Li L, Chen YS, Dashwood WM, Nguyen N, Ulusan AM, Ertem FU, Zhang M, Li J, Sun D, Huang Y, Wang S, Leung HE, Lieberman D, ... ... Bedford MT, et al. Acetylation of CCAR2 establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition. Cancer Research. PMID 30643017 DOI: 10.1158/0008-5472.Can-18-2003 |
0.498 |
|
| 2019 |
Su H, Liu S, Sun C, Bedford MT, Zhao X. Protein Arginine Methyltransferase 1 (PRMT1) Dampens Self-Renewal and Promotes Differentiation of Hematopoietic Stem Cells in Mouse Models Blood. 134: 2460-2460. DOI: 10.1182/Blood-2019-127226 |
0.414 |
|
| 2019 |
Johnson GS, Rajendran P, Li L, Chen Y, Dashwood WM, Nguyen N, Ulusan AM, Ertem F, Zhang M, Sun D, Huang Y, Wang S, Leung HE, Lieberman D, Beaver LM, ... ... Bedford MT, et al. Abstract 2614: CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition Cancer Research. 79: 2614-2614. DOI: 10.1158/1538-7445.Am2019-2614 |
0.503 |
|
| 2018 |
Hupalowska A, Jedrusik A, Zhu M, Bedford MT, Glover DM, Zernicka-Goetz M. CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development. Cell. 175: 1902-1916.e13. PMID 30550788 DOI: 10.1016/J.Cell.2018.11.027 |
0.405 |
|
| 2018 |
Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, et al. Correction to "Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1". Biochemistry. PMID 30485080 DOI: 10.1021/Acs.Biochem.8B01187 |
0.371 |
|
| 2018 |
Cheng D, Vemulapalli V, Lu Y, Shen J, Aoyagi S, Fry CJ, Yang Y, Foulds CE, Stossi F, Treviño LS, Mancini MA, O'Malley BW, Walker CL, Boyer TG, Bedford MT. CARM1 methylates MED12 to regulate its RNA-binding ability. Life Science Alliance. 1: e201800117. PMID 30456381 DOI: 10.26508/lsa.201800117 |
0.458 |
|
| 2018 |
Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Gaitán-Peñas H, Guénet JL, Lin K, ... ... Bedford MT, et al. Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. Jci Insight. 3. PMID 30135305 DOI: 10.1172/Jci.Insight.99767 |
0.342 |
|
| 2018 |
Hamidi T, Singh AK, Veland N, Vemulapalli V, Chen J, Hardikar S, Bao J, Fry CJ, Yang V, Lee KA, Guo A, Arrowsmith CH, Bedford MT, Chen T. Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9. The Journal of Biological Chemistry. PMID 29959229 DOI: 10.1074/Jbc.Ra118.002890 |
0.494 |
|
| 2018 |
Bao J, Rousseaux S, Shen J, Lin K, Lu Y, Bedford MT. The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis. Nucleic Acids Research. PMID 29659998 DOI: 10.1093/Nar/Gky240 |
0.458 |
|
| 2018 |
Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, et al. Quantitative characterization of bivalent probes for a dual bromodomain protein, Transcription Initiation Factor TFIID subunit 1, TAF1. Biochemistry. PMID 29558110 DOI: 10.1021/Acs.Biochem.8B00150 |
0.329 |
|
| 2018 |
Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, et al. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. Bmc Genomics. 19: 150. PMID 29458327 DOI: 10.1186/S12864-018-4533-0 |
0.388 |
|
| 2018 |
Hossain MB, Shifat R, Kim DK, Rivera-Molina Y, Martinez FP, Jiang H, Nguyen T, Johnson DG, Bedford MT, Hung M, Sulman EP, Lang F, Sawaya R, Fueyo J, Gomez-Manzano C. Abstract 3205: Histone tyrosine phosphorylation determines glioblastoma cell survival Cancer Research. 78: 3205-3205. DOI: 10.1158/1538-7445.Am2018-3205 |
0.466 |
|
| 2018 |
Avasarala S, Wu P, Khan SQ, Scoyk MV, Su Y, David O, Gupta V, Bedford MT, Winn RA, Bikkavilli RK. Abstract 138: PRMT6 promotes lung tumor growth via the modulation of macrophage M2 polarization Cancer Research. 78: 138-138. DOI: 10.1158/1538-7445.Am2018-138 |
0.312 |
|
| 2017 |
Franco HL, Nagari A, Malladi V, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, et al. Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis. Genome Research. PMID 29273624 DOI: 10.1101/Gr.226019.117 |
0.344 |
|
| 2017 |
Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T. The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. Cell Reports. 21: 3390-3397. PMID 29262320 DOI: 10.1016/J.Celrep.2017.11.082 |
0.482 |
|
| 2017 |
Carr SM, Munro S, Sagum CA, Fedorov O, Bedford MT, La Thangue NB. Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein. Cell Death and Differentiation. PMID 28841214 DOI: 10.1038/Cdd.2017.135 |
0.528 |
|
| 2017 |
Han Z, Sagum CA, Takizawa F, Ruthel G, Berry CT, Kong J, Sunyer JO, Freedman BD, Bedford MT, Sidhu SS, Sudol M, Harty RN. Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 to Regulate Egress. Journal of Virology. PMID 28768865 DOI: 10.1128/Jvi.00812-17 |
0.369 |
|
| 2017 |
Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN. Correction: Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. Plos Pathogens. 13: e1006519. PMID 28723972 DOI: 10.1371/Journal.Ppat.1006519 |
0.315 |
|
| 2017 |
Gates LA, Shi J, Rohira AD, Feng Q, Zhu B, Bedford MT, Sagum CA, Jung SY, Qin J, Tsai MJ, Tsai SY, Li W, Foulds CE, O'Malley BW. Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation. The Journal of Biological Chemistry. 292: 14456-14472. PMID 28717009 DOI: 10.1074/Jbc.M117.802074 |
0.487 |
|
| 2017 |
Kaushik S, Liu F, Veazey K, Gao G, Das P, Neves L, Li K, Zhong Y, Lu Y, Giuliani V, Bedford MT, Nimer SD, Santos MA. Genetic deletion or small molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML. Leukemia. PMID 28663579 DOI: 10.1038/Leu.2017.206 |
0.399 |
|
| 2017 |
Bae N, Viviano M, Su X, Lv J, Cheng D, Sagum C, Castellano S, Bai X, Johnson C, Khalil MI, Shen J, Chen K, Li H, Sbardella G, Bedford MT. Developing Spindlin1 small-molecule inhibitors by using protein microarrays. Nature Chemical Biology. PMID 28504676 DOI: 10.1038/Nchembio.2377 |
0.44 |
|
| 2017 |
Shanle EK, Shinsky SA, Bridgers JB, Bae N, Sagum C, Krajewski K, Rothbart SB, Bedford MT, Strahl BD. Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics & Chromatin. 10: 12. PMID 28293301 DOI: 10.1186/S13072-017-0117-5 |
0.479 |
|
| 2017 |
Gao G, Dhar S, Bedford MT. PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1. Nucleic Acids Research. PMID 28115626 DOI: 10.1093/Nar/Gkw1367 |
0.455 |
|
| 2017 |
Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN. Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. Plos Pathogens. 13: e1006132. PMID 28076420 DOI: 10.1371/Journal.Ppat.1006132 |
0.382 |
|
| 2017 |
Hossain MB, Shifat R, Li J, Rivera-Mokina Y, Martinez FP, Johnson DG, Bedford MT, Hung M, Sulman EP, Lang F, Sawaya R, Fueyo J, Gomez-Manzano C. Abstract 5854: TIE2-mediated epigenetic marks regulate therapeutic resistance of glioblastoma Cancer Research. 77: 5854-5854. DOI: 10.1158/1538-7445.Am2017-5854 |
0.371 |
|
| 2017 |
Hossain M, Shifat R, Rivera-Molina Y, Puerta-Martinez F, Jiang H, Kim D, Johnson D, Bedford M, Sulman E, Lang F, Fueyo J, Gomez-Manzano C. GENE-19. TIE2-MEDIATED EPIGENETIC MODIFICATIONS REGULATE RADIORESISTANCE OF GLIOBLASTOMA Neuro-Oncology. 19: vi96-vi96. DOI: 10.1093/Neuonc/Nox168.393 |
0.465 |
|
| 2016 |
Barnea M, Olender T, Bedford MT, Elson A. Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains. Biochemical Society Transactions. 44: 1295-1303. PMID 27911712 DOI: 10.1042/Bst20160141 |
0.402 |
|
| 2016 |
Norrie JL, Li Q, Co S, Huang BL, Ding D, Uy JC, Ji Z, Mackem S, Bedford MT, Galli A, Ji H, Vokes SA. PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development (Cambridge, England). PMID 27827819 DOI: 10.1242/Dev.140715 |
0.321 |
|
| 2016 |
Tsai WC, Gayatri S, Reineke LC, Sbardella G, Bedford MT, Lloyd RE. Arginine demethylation of G3BP1 promotes stress granule assembly. The Journal of Biological Chemistry. PMID 27601476 DOI: 10.1074/Jbc.M116.739573 |
0.494 |
|
| 2016 |
Park IY, Powell RT, Tripathi DN, Dere R, Ho TH, Blasius TL, Chiang YC, Davis IJ, Fahey CC, Hacker KE, Verhey KJ, Bedford MT, Jonasch E, Rathmell WK, Walker CL. Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell. 166: 950-62. PMID 27518565 DOI: 10.1016/J.Cell.2016.07.005 |
0.48 |
|
| 2016 |
Han Z, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN. ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 to Regulate Budding. Journal of Virology. PMID 27489272 DOI: 10.1128/Jvi.01078-16 |
0.319 |
|
| 2016 |
Gayatri S, Cowles MW, Vemulapalli V, Cheng D, Sun ZW, Bedford MT. Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Scientific Reports. 6: 28718. PMID 27338245 DOI: 10.1038/Srep28718 |
0.469 |
|
| 2016 |
Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG, Li W, Bedford MT, Shi X. G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Nature Communications. 7: 10810. PMID 26960573 DOI: 10.1038/Ncomms10810 |
0.5 |
|
| 2016 |
Bao J, Bedford MT. Epigenetic regulation of the histone-to-protamine transition during spermiogenesis. Reproduction (Cambridge, England). 151: R55-70. PMID 26850883 DOI: 10.1530/Rep-15-0562 |
0.495 |
|
| 2016 |
Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, ... ... Bedford MT, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 26807715 DOI: 10.1038/Nchembio.2007 |
0.471 |
|
| 2016 |
Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, ... ... Bedford MT, et al. Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Nature Structural & Molecular Biology. 23: 132-9. PMID 26751641 DOI: 10.1038/Nsmb.3153 |
0.391 |
|
| 2015 |
Estève PO, Zhang G, Ponnaluri VK, Deepti K, Chin HG, Dai N, Sagum C, Black K, Corrêa IR, Bedford MT, Cheng X, Pradhan S. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Research. PMID 26553800 DOI: 10.1093/Nar/Gkv1162 |
0.472 |
|
| 2015 |
Perez CJ, Mecklenburg L, Jaubert J, Martinez-Santamaria L, Iritani BM, Espejo A, Napoli E, Song G, Del Río M, DiGiovanni J, Giulivi C, Bedford MT, Dent SY, Wood RD, Kusewitt DF, et al. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. The Journal of Investigative Dermatology. PMID 26288350 DOI: 10.1038/Jid.2015.314 |
0.303 |
|
| 2015 |
Hadjikyriacou A, Yang Y, Espejo A, Bedford MT, Clarke SG. Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and its Substrate RNA Splicing Factor SF3B2. The Journal of Biological Chemistry. PMID 25979344 DOI: 10.1074/Jbc.M115.659433 |
0.328 |
|
| 2015 |
Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X. Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Molecular Cell. 58: 863-9. PMID 25959398 DOI: 10.1016/J.Molcel.2015.03.032 |
0.379 |
|
| 2015 |
Hu SB, Xiang JF, Li X, Xu Y, Xue W, Huang M, Wong CC, Sagum CA, Bedford MT, Yang L, Cheng D, Chen LL. Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus. Genes & Development. 29: 630-45. PMID 25792598 DOI: 10.1101/Gad.257048.114 |
0.452 |
|
| 2015 |
Yang Y, Hadjikyriacou A, Xia Z, Gayatri S, Kim D, Zurita-Lopez C, Kelly R, Guo A, Li W, Clarke SG, Bedford MT. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Nature Communications. 6: 6428. PMID 25737013 DOI: 10.1038/Ncomms7428 |
0.53 |
|
| 2015 |
James LI, Stuckey JI, Baughman BM, Perfetti MT, Pattenden SG, Dickson BM, Norris JL, Cui G, Mader P, Dong A, Mu Y, Rothbart SB, Strahl BD, Min J, Brown PJ, ... ... Bedford MT, et al. Abstract SY08-03: Targeting chromatin regulation for cancer therapy: progress towards chemical probes for methyl-lysine readers Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Sy08-03 |
0.474 |
|
| 2015 |
Hossain MB, Shifat R, Johnson DG, Bedford MT, Hung M, Cortes-Santiago N, Gabrusiewicz K, Gumin J, Ezhilarasan R, Sulman EP, Lang F, Sawaya R, Yung WKA, Fueyo J, Gomez-Manzano C. Abstract 3298: ABL1 is required for Tie2-mediated DNA repair in brain tumor stem cells Cancer Research. 75: 3298-3298. DOI: 10.1158/1538-7445.Am2015-3298 |
0.357 |
|
| 2015 |
Hossain MB, Shifat R, Johnson DG, Bedford MT, Hung M, Gabrusiewicz K, Gumin J, Ezhilarasan R, Sulman EP, Lang F, Tyler J, Sawaya R, Yung WA, Fueyo J, Gomez-Manzano C. RTRB-10TYROSINE KINASE RECEPTOR TIE2 REGULATES DNA REPAIR THROUGH THE PROTO-ONCOGENE ABL1 IN BRAIN TUMOR STEM CELLS Neuro-Oncology. 17: v197.2-v197. DOI: 10.1093/Neuonc/Nov231.10 |
0.327 |
|
| 2014 |
Levy-Apter E, Finkelshtein E, Vemulapalli V, Li SS, Bedford MT, Elson A. Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts. The Journal of Biological Chemistry. 289: 36048-58. PMID 25381250 DOI: 10.1074/Jbc.M114.603548 |
0.365 |
|
| 2014 |
Carr SM, Munro S, Zalmas LP, Fedorov O, Johansson C, Krojer T, Sagum CA, Bedford MT, Oppermann U, La Thangue NB. Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 111: 11341-6. PMID 25049398 DOI: 10.1073/pnas.1403737111 |
0.4 |
|
| 2014 |
Di Lorenzo A, Yang Y, Macaluso M, Bedford MT. A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator. Nucleic Acids Research. 42: 8297-309. PMID 24939901 DOI: 10.1093/Nar/Gku530 |
0.448 |
|
| 2014 |
Gayatri S, Bedford MT. Readers of histone methylarginine marks. Biochimica Et Biophysica Acta. 1839: 702-10. PMID 24583552 DOI: 10.1016/J.Bbagrm.2014.02.015 |
0.571 |
|
| 2014 |
Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford MT. Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Molecular Cell. 53: 484-97. PMID 24507716 DOI: 10.1016/J.Molcel.2014.01.011 |
0.458 |
|
| 2014 |
Estève PO, Terragni J, Deepti K, Chin HG, Dai N, Espejo A, Corrêa IR, Bedford MT, Pradhan S. Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. The Journal of Biological Chemistry. 289: 8277-87. PMID 24492612 DOI: 10.1074/Jbc.M113.525279 |
0.515 |
|
| 2014 |
Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, et al. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Molecular & Cellular Proteomics : McP. 13: 372-87. PMID 24129315 DOI: 10.1074/Mcp.O113.027870 |
0.548 |
|
| 2014 |
Hadjikyriacou A, Yang Y, Bedford M, Clarke S. Characterization of the Activity and Biological Function of Human Protein Arginine Methyltransferase 9 (PRMT9) The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.Lb211 |
0.477 |
|
| 2013 |
Feng Y, Maity R, Whitelegge JP, Hadjikyriacou A, Li Z, Zurita-Lopez C, Al-Hadid Q, Clark AT, Bedford MT, Masson JY, Clarke SG. Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. The Journal of Biological Chemistry. 288: 37010-25. PMID 24247247 DOI: 10.1074/Jbc.M113.525345 |
0.543 |
|
| 2013 |
Zheng S, Moehlenbrink J, Lu YC, Zalmas LP, Sagum CA, Carr S, McGouran JF, Alexander L, Fedorov O, Munro S, Kessler B, Bedford MT, Yu Q, La Thangue NB. Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Molecular Cell. 52: 37-51. PMID 24076217 DOI: 10.1016/j.molcel.2013.08.039 |
0.412 |
|
| 2013 |
Zeng H, Wu J, Bedford MT, Sbardella G, Hoffmann FM, Bi K, Xu W. A TR-FRET-based functional assay for screening activators of CARM1. Chembiochem : a European Journal of Chemical Biology. 14: 827-35. PMID 23585185 DOI: 10.1002/Cbic.201300029 |
0.435 |
|
| 2013 |
Dhar S, Vemulapalli V, Patananan AN, Huang GL, Di Lorenzo A, Richard S, Comb MJ, Guo A, Clarke SG, Bedford MT. Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Scientific Reports. 3: 1311. PMID 23419748 DOI: 10.1038/Srep01311 |
0.477 |
|
| 2013 |
James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, ... ... Bedford MT, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature Chemical Biology. 9: 184-91. PMID 23292653 DOI: 10.1038/Nchembio.1157 |
0.406 |
|
| 2013 |
Li J, Zhao Z, Carter C, Ehrlich LI, Bedford MT, Richie ER. Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. Journal of Immunology (Baltimore, Md. : 1950). 190: 597-604. PMID 23248263 DOI: 10.4049/Jimmunol.1102513 |
0.419 |
|
| 2013 |
Yang Y, Bedford MT. Protein arginine methyltransferases and cancer. Nature Reviews. Cancer. 13: 37-50. PMID 23235912 DOI: 10.1038/Nrc3409 |
0.493 |
|
| 2012 |
Yang Y, Bedford MT. Titivated for destruction: the methyl degron. Molecular Cell. 48: 487-8. PMID 23200121 DOI: 10.1016/J.Molcel.2012.11.007 |
0.453 |
|
| 2012 |
Castellano S, Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, et al. Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. Journal of Medicinal Chemistry. 55: 9875-90. PMID 23095008 DOI: 10.1021/Jm301097P |
0.545 |
|
| 2012 |
Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nature Structural & Molecular Biology. 19: 1155-60. PMID 23022729 DOI: 10.1038/Nsmb.2391 |
0.497 |
|
| 2012 |
Cheng D, Vemulapalli V, Bedford MT. Methods applied to the study of protein arginine methylation. Methods in Enzymology. 512: 71-92. PMID 22910203 DOI: 10.1016/B978-0-12-391940-3.00004-4 |
0.519 |
|
| 2012 |
Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G. PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nature Structural & Molecular Biology. 19: 916-24. PMID 22864287 DOI: 10.1038/Nsmb.2353 |
0.388 |
|
| 2012 |
Kawabe Y, Wang YX, McKinnell IW, Bedford MT, Rudnicki MA. Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell. 11: 333-45. PMID 22863532 DOI: 10.1016/J.Stem.2012.07.001 |
0.52 |
|
| 2012 |
Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging. 4: 462-79. PMID 22820736 |
0.491 |
|
| 2012 |
Liu K, Guo Y, Liu H, Bian C, Lam R, Liu Y, Mackenzie F, Rojas LA, Reinberg D, Bedford MT, Xu RM, Min J. Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. Plos One. 7: e30375. PMID 22363433 DOI: 10.1371/Journal.Pone.0030375 |
0.489 |
|
| 2012 |
Zhao H, Ho PC, Lo YH, Espejo A, Bedford MT, Hung MC, Wang SC. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. Plos One. 7: e29416. PMID 22238610 DOI: 10.1371/Journal.Pone.0029416 |
0.347 |
|
| 2012 |
Badeaux AI, Yang Y, Cardenas K, Vemulapalli V, Chen K, Kusewitt D, Richie E, Li W, Bedford MT. Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. The Journal of Biological Chemistry. 287: 429-37. PMID 22072714 DOI: 10.1074/Jbc.M111.271163 |
0.566 |
|
| 2012 |
Rothbart SB, Fuchs SM, Nady N, Krajewski K, Tempel W, Xue S, Iberg AN, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Arrowsmith CH, Strahl BD. Abstract 993: A high-throughput peptide array screen of H3K9 methyl effectors identifies UHRF1 as an exception to the “phospho/methyl switch.” Cancer Research. 72: 993-993. DOI: 10.1158/1538-7445.Am2012-993 |
0.814 |
|
| 2012 |
Zhao HJ, Ho P, Lo Y, Espejo A, Bedford MT, Hung M, Wang S. Abstract 3036: Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer Cancer Research. 72: 3036-3036. DOI: 10.1158/1538-7445.Am2012-3036 |
0.343 |
|
| 2011 |
Chang Y, Sun L, Kokura K, Horton JR, Fukuda M, Espejo A, Izumi V, Koomen JM, Bedford MT, Zhang X, Shinkai Y, Fang J, Cheng X. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nature Communications. 2: 533. PMID 22086334 DOI: 10.1038/Ncomms1549 |
0.478 |
|
| 2011 |
Cheng D, Valente S, Castellano S, Sbardella G, Di Santo R, Costi R, Bedford MT, Mai A. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. Journal of Medicinal Chemistry. 54: 4928-32. PMID 21612300 DOI: 10.1021/Jm200453N |
0.336 |
|
| 2011 |
Guo Q, Bedford MT, Fast W. Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Molecular Biosystems. 7: 2286-95. PMID 21584310 DOI: 10.1039/C1Mb05089C |
0.498 |
|
| 2011 |
Bissinger EM, Heinke R, Spannhoff A, Eberlin A, Metzger E, Cura V, Hassenboehler P, Cavarelli J, Schüle R, Bedford MT, Sippl W, Jung M. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1 Bioorganic and Medicinal Chemistry. 19: 3717-3731. PMID 21440447 DOI: 10.1016/J.Bmc.2011.02.032 |
0.49 |
|
| 2011 |
Chang Y, Horton JR, Bedford MT, Zhang X, Cheng X. Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. Journal of Molecular Biology. 408: 807-14. PMID 21419134 DOI: 10.1016/J.Jmb.2011.03.018 |
0.49 |
|
| 2011 |
Spannhoff A, Kim YK, Raynal NJ, Gharibyan V, Su MB, Zhou YY, Li J, Castellano S, Sbardella G, Issa JP, Bedford MT. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. Embo Reports. 12: 238-43. PMID 21331099 DOI: 10.1038/Embor.2011.9 |
0.447 |
|
| 2011 |
Butler JS, Zurita-Lopez CI, Clarke SG, Bedford MT, Dent SY. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. The Journal of Biological Chemistry. 286: 12234-44. PMID 21285357 DOI: 10.1074/Jbc.M110.202416 |
0.533 |
|
| 2011 |
Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nature Cell Biology. 13: 174-81. PMID 21258366 DOI: 10.1038/Ncb2158 |
0.407 |
|
| 2011 |
Lee YH, Bedford MT, Stallcup MR. Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes & Development. 25: 176-88. PMID 21245169 DOI: 10.1101/Gad.1975811 |
0.429 |
|
| 2011 |
Cheng D, Bedford MT. Xenoestrogens regulate the activity of arginine methyltransferases. Chembiochem : a European Journal of Chemical Biology. 12: 323-9. PMID 21243720 DOI: 10.1002/Cbic.201000522 |
0.432 |
|
| 2011 |
Cha B, Kim W, Kim YK, Hwang BN, Park SY, Yoon JW, Park WS, Cho JW, Bedford MT, Jho EH. Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Oncogene. 30: 2379-89. PMID 21242974 DOI: 10.1038/onc.2010.610 |
0.351 |
|
| 2011 |
Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, ... ... Bedford MT, et al. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nature Immunology. 12: 29-36. PMID 21131967 DOI: 10.1038/Ni.1968 |
0.551 |
|
| 2011 |
Di Lorenzo A, Bedford MT. Histone arginine methylation. Febs Letters. 585: 2024-31. PMID 21074527 DOI: 10.1016/J.Febslet.2010.11.010 |
0.549 |
|
| 2010 |
Yang Y, Lu Y, Espejo A, Wu J, Xu W, Liang S, Bedford MT. TDRD3 is an effector molecule for arginine-methylated histone marks. Molecular Cell. 40: 1016-23. PMID 21172665 DOI: 10.1016/J.Molcel.2010.11.024 |
0.565 |
|
| 2010 |
Kokura K, Sun L, Bedford MT, Fang J. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. The Embo Journal. 29: 3673-87. PMID 20871592 DOI: 10.1038/Emboj.2010.239 |
0.523 |
|
| 2010 |
Liu H, Galka M, Iberg A, Wang Z, Li L, Voss C, Jiang X, Lajoie G, Huang Z, Bedford MT, Li SS. Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. Journal of Proteome Research. 9: 5827-36. PMID 20836566 DOI: 10.1021/Pr100597B |
0.8 |
|
| 2010 |
Zhu F, Dollé ME, Berton TR, Kuiper RV, Capps C, Espejo A, McArthur MJ, Bedford MT, van Steeg H, de Vries A, Johnson DG. Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Research. 70: 5851-9. PMID 20587514 DOI: 10.1158/0008-5472.Can-09-4646 |
0.323 |
|
| 2010 |
O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, ... Bedford MT, et al. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development (Cambridge, England). 137: 2147-56. PMID 20530543 DOI: 10.1242/Dev.037150 |
0.71 |
|
| 2010 |
Chang Y, Ganesh T, Horton JR, Spannhoff A, Liu J, Sun A, Zhang X, Bedford MT, Shinkai Y, Snyder JP, Cheng X. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. Journal of Molecular Biology. 400: 1-7. PMID 20434463 DOI: 10.1016/J.Jmb.2010.04.048 |
0.503 |
|
| 2010 |
Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Molecular Endocrinology (Baltimore, Md.). 24: 993-1006. PMID 20351197 DOI: 10.1210/Me.2009-0438 |
0.416 |
|
| 2010 |
Short JD, Dere R, Houston KD, Cai SL, Kim J, Bergeron JM, Shen J, Liang J, Bedford MT, Mills GB, Walker CL. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Molecular Carcinogenesis. 49: 429-39. PMID 20146253 DOI: 10.1002/Mc.20613 |
0.359 |
|
| 2010 |
Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). Chemmedchem. 5: 398-414. PMID 20091730 DOI: 10.1002/Cmdc.200900459 |
0.352 |
|
| 2010 |
Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Research. 38: e11. PMID 19897549 DOI: 10.1093/Nar/Gkp899 |
0.54 |
|
| 2010 |
Kim D, Lee J, Cheng D, Li J, Carter C, Richie E, Bedford MT. Enzymatic activity is required for the in vivo functions of CARM1. The Journal of Biological Chemistry. 285: 1147-52. PMID 19897492 DOI: 10.1074/Jbc.M109.035865 |
0.516 |
|
| 2009 |
Bua DJ, Kuo AJ, Cheung P, Liu CL, Migliori V, Espejo A, Casadio F, Bassi C, Amati B, Bedford MT, Guccione E, Gozani O. Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. Plos One. 4: e6789. PMID 19956676 DOI: 10.1371/Journal.Pone.0006789 |
0.515 |
|
| 2009 |
Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M, Ozaki T, Lotz M, Bedford MT, Asahara H. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. Bmc Developmental Biology. 9: 47. PMID 19725955 DOI: 10.1186/1471-213X-9-47 |
0.749 |
|
| 2009 |
Lu M, Yang J, Ren Z, Sabui S, Espejo A, Bedford MT, Jacobson RH, Jeruzalmi D, McMurray JS, Chen X. Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. Journal of Molecular Biology. 393: 397-408. PMID 19660470 DOI: 10.1016/J.Jmb.2009.07.086 |
0.371 |
|
| 2009 |
Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nature Structural & Molecular Biology. 16: 312-7. PMID 19219047 DOI: 10.1038/Nsmb.1560 |
0.498 |
|
| 2009 |
Herrmann F, Pably P, Eckerich C, Bedford MT, Fackelmayer FO. Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. Journal of Cell Science. 122: 667-77. PMID 19208762 DOI: 10.1242/Jcs.039933 |
0.443 |
|
| 2009 |
Dacwag CS, Bedford MT, Sif S, Imbalzano AN. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Molecular and Cellular Biology. 29: 1909-21. PMID 19188441 DOI: 10.1128/Mcb.00742-08 |
0.31 |
|
| 2009 |
Bedford MT, Clarke SG. Protein arginine methylation in mammals: who, what, and why. Molecular Cell. 33: 1-13. PMID 19150423 DOI: 10.1016/J.Molcel.2008.12.013 |
0.538 |
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| 2009 |
Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT, Tian Y. Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. The Journal of Biological Chemistry. 284: 9199-205. PMID 19144646 DOI: 10.1074/Jbc.M806193200 |
0.563 |
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| 2008 |
Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes & Development. 22: 2048-61. PMID 18676810 DOI: 10.1101/Gad.476008 |
0.427 |
|
| 2008 |
Mai A, Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G, Sbardella G, De Bellis F, Miceli M, Altucci L. epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. Journal of Medicinal Chemistry. 51: 2279-90. PMID 18348515 DOI: 10.1021/Jm701595Q |
0.399 |
|
| 2008 |
Hassa PO, Covic M, Bedford MT, Hottiger MO. Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. Journal of Molecular Biology. 377: 668-78. PMID 18280497 DOI: 10.1016/J.Jmb.2008.01.044 |
0.449 |
|
| 2008 |
Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, Bedford MT. CARM1 promotes adipocyte differentiation by coactivating PPARgamma. Embo Reports. 9: 193-8. PMID 18188184 DOI: 10.1038/Sj.Embor.7401151 |
0.741 |
|
| 2008 |
Iberg AN, Espejo A, Cheng D, Kim D, Michaud-Levesque J, Richard S, Bedford MT. Arginine methylation of the histone H3 tail impedes effector binding. The Journal of Biological Chemistry. 283: 3006-10. PMID 18077460 DOI: 10.1074/Jbc.C700192200 |
0.816 |
|
| 2007 |
Bedford MT. Arginine methylation at a glance. Journal of Cell Science. 120: 4243-6. PMID 18057026 DOI: 10.1242/Jcs.019885 |
0.506 |
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| 2007 |
Sayegh J, Webb K, Cheng D, Bedford MT, Clarke SG. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. The Journal of Biological Chemistry. 282: 36444-53. PMID 17925405 DOI: 10.1074/Jbc.M704650200 |
0.405 |
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| 2007 |
Ludes-Meyers JH, Kil H, Nuñez MI, Conti CJ, Parker-Thornburg J, Bedford MT, Aldaz CM. WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes, Chromosomes & Cancer. 46: 1129-36. PMID 17823927 DOI: 10.1002/Gcc.20497 |
0.308 |
|
| 2007 |
Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL. p53 is regulated by the lysine demethylase LSD1. Nature. 449: 105-8. PMID 17805299 DOI: 10.1038/Nature06092 |
0.532 |
|
| 2007 |
Mai A, Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, Bedford MT. Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. Chemmedchem. 2: 987-91. PMID 17458842 DOI: 10.1002/Cmdc.200700023 |
0.571 |
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| 2007 |
Swiercz R, Cheng D, Kim D, Bedford MT. Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. The Journal of Biological Chemistry. 282: 16917-23. PMID 17439947 DOI: 10.1074/Jbc.M609778200 |
0.385 |
|
| 2007 |
Shaaban SA, Bedford MT. Reprogramming the histone code. Chemistry & Biology. 14: 242-4. PMID 17379139 DOI: 10.1016/J.Chembiol.2007.03.001 |
0.398 |
|
| 2007 |
Lake AN, Bedford MT. Protein methylation and DNA repair. Mutation Research. 618: 91-101. PMID 17306845 DOI: 10.1016/J.Mrfmmm.2006.09.010 |
0.371 |
|
| 2007 |
Cheng D, Côté J, Shaaban S, Bedford MT. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Molecular Cell. 25: 71-83. PMID 17218272 DOI: 10.1016/J.Molcel.2006.11.019 |
0.489 |
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| 2007 |
Shi X, Kachirskaia I, Walter KL, Kuo JH, Lake A, Davrazou F, Chan SM, Martin DG, Fingerman IM, Briggs SD, Howe L, Utz PJ, Kutateladze TG, Lugovskoy AA, Bedford MT, et al. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. The Journal of Biological Chemistry. 282: 2450-5. PMID 17142463 DOI: 10.1074/Jbc.C600286200 |
0.529 |
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| 2006 |
Bedford MT. 2 The family of protein arginine metkyltransferases. The Enzymes. 24: 31-50. PMID 26718036 DOI: 10.1016/S1874-6047(06)80004-1 |
0.536 |
|
| 2006 |
El Messaoudi S, Fabbrizio E, Rodriguez C, Chuchana P, Fauquier L, Cheng D, Theillet C, Vandel L, Bedford MT, Sardet C. Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proceedings of the National Academy of Sciences of the United States of America. 103: 13351-6. PMID 16938873 DOI: 10.1073/Pnas.0605692103 |
0.48 |
|
| 2006 |
Huang Y, Fang J, Bedford MT, Zhang Y, Xu RM. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (New York, N.Y.). 312: 748-51. PMID 16601153 DOI: 10.1126/Science.1125162 |
0.512 |
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| 2006 |
Kim J, Daniel J, Espejo A, Lake A, Krishna M, Xia L, Zhang Y, Bedford MT. Tudor, MBT and chromo domains gauge the degree of lysine methylation. Embo Reports. 7: 397-403. PMID 16415788 DOI: 10.1038/Sj.Embor.7400625 |
0.538 |
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| 2006 |
Sgarra R, Lee J, Tessari MA, Altamura S, Spolaore B, Giancotti V, Bedford MT, Manfioletti G. The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. The Journal of Biological Chemistry. 281: 3764-72. PMID 16293633 DOI: 10.1074/Jbc.M510231200 |
0.526 |
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| 2005 |
Herrmann F, Lee J, Bedford MT, Fackelmayer FO. Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo. The Journal of Biological Chemistry. 280: 38005-10. PMID 16159886 DOI: 10.1074/Jbc.M502458200 |
0.503 |
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| 2005 |
Lee J, Sayegh J, Daniel J, Clarke S, Bedford MT. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. The Journal of Biological Chemistry. 280: 32890-6. PMID 16051612 DOI: 10.1074/Jbc.M506944200 |
0.446 |
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| 2005 |
Bedford MT, Richard S. Arginine methylation: An emerging regulator of protein function Molecular Cell. 18: 263-272. PMID 15866169 DOI: 10.1016/J.Molcel.2005.04.003 |
0.515 |
|
| 2005 |
Boulanger MC, Liang C, Russell RS, Lin R, Bedford MT, Wainberg MA, Richard S. Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. Journal of Virology. 79: 124-31. PMID 15596808 DOI: 10.1128/Jvi.79.1.124-131.2005 |
0.379 |
|
| 2005 |
Swiercz R, Person MD, Bedford MT. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3) Biochemical Journal. 386: 85-91. PMID 15473865 DOI: 10.1042/Bj20041466 |
0.479 |
|
| 2004 |
Lee J, Cheng D, Bedford MT. Techniques in protein methylation. Methods in Molecular Biology (Clifton, N.J.). 284: 195-208. PMID 15173617 DOI: 10.1385/1-59259-816-1:195 |
0.507 |
|
| 2004 |
Kim J, Lee J, Yadav N, Wu Q, Carter C, Richard S, Richie E, Bedford MT. Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. The Journal of Biological Chemistry. 279: 25339-44. PMID 15096520 DOI: 10.1074/Jbc.M402544200 |
0.767 |
|
| 2004 |
Ludes-Meyers JH, Kil H, Bednarek AK, Drake J, Bedford MT, Aldaz CM. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 23: 5049-55. PMID 15064722 DOI: 10.1038/Sj.Onc.1207680 |
0.415 |
|
| 2004 |
Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. The Journal of Biological Chemistry. 279: 23892-9. PMID 15056663 DOI: 10.1074/Jbc.M401853200 |
0.772 |
|
| 2004 |
Espejo A, Bedford MT. Protein-domain microarrays. Methods in Molecular Biology (Clifton, N.J.). 264: 173-81. PMID 15020789 DOI: 10.1385/1-59259-759-9:173 |
0.414 |
|
| 2003 |
Ludes-Meyers JH, Bednarek AK, Popescu NC, Bedford MT, Aldaz CM. WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenetic and Genome Research. 100: 101-110. PMID 14526170 DOI: 10.1159/000072844 |
0.371 |
|
| 2003 |
Yadav N, Lee J, Kim J, Shen J, Hu MC, Aldaz CM, Bedford MT. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 6464-8. PMID 12756295 DOI: 10.1073/Pnas.1232272100 |
0.791 |
|
| 2003 |
Côté J, Boisvert FM, Boulanger MC, Bedford MT, Richard S. Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Molecular Biology of the Cell. 14: 274-87. PMID 12529443 DOI: 10.1091/Mbc.E02-08-0484 |
0.442 |
|
| 2002 |
Espejo A, Côté J, Bednarek A, Richard S, Bedford MT. A protein-domain microarray identifies novel protein-protein interactions. The Biochemical Journal. 367: 697-702. PMID 12137563 DOI: 10.1042/Bj20020860 |
0.407 |
|
| 2002 |
Lee J, Bedford MT. PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. Embo Reports. 3: 268-73. PMID 11850402 DOI: 10.1093/Embo-Reports/Kvf052 |
0.518 |
|
| 2002 |
Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. The Journal of Biological Chemistry. 277: 3537-43. PMID 11724789 DOI: 10.1074/Jbc.M108786200 |
0.735 |
|
| 2001 |
Sotgia F, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP. Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Biochemistry. 40: 14585-92. PMID 11724572 DOI: 10.1021/Bi011247R |
0.336 |
|
| 2000 |
Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. The Journal of Biological Chemistry. 275: 16030-6. PMID 10748127 DOI: 10.1074/Jbc.M909368199 |
0.43 |
|
| 2000 |
Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB. A novel pro-Arg motif recognized by WW domains. The Journal of Biological Chemistry. 275: 10359-69. PMID 10744724 DOI: 10.1074/Jbc.275.14.10359 |
0.349 |
|
| 1999 |
Rentschler S, Linn H, Deininger K, Bedford MT, Espanel X, Sudol M. The WW domain of dystrophin requires EF-hands region to interact with β-dystroglycan Biological Chemistry. 380: 431-442. PMID 10355629 DOI: 10.1515/Bc.1999.057 |
0.317 |
|
| 1996 |
Chan DC, Bedford MT, Leder P. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. The Embo Journal. 15: 1045-54. PMID 8605874 DOI: 10.1002/J.1460-2075.1996.Tb00442.X |
0.387 |
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