| Year |
Citation |
Score |
| 2017 |
Heier JS, Kherani S, Desai S, Dugel P, Kaushal S, Cheng SH, Delacono C, Purvis A, Richards S, Le-Halpere A, Connelly J, Wadsworth SC, Varona R, Buggage R, Scaria A, et al. Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial. Lancet (London, England). PMID 28526489 DOI: 10.1016/S0140-6736(17)30979-0 |
0.323 |
|
| 2017 |
Lei L, Tzekov R, Li H, McDowell JH, Gao G, Smith WC, Tang S, Kaushal S. Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell. International Journal of Molecular Sciences. 18. PMID 28353645 DOI: 10.3390/Ijms18040728 |
0.391 |
|
| 2016 |
Weleber RG, Pennesi ME, Wilson DJ, Kaushal S, Erker LR, Jensen L, McBride MT, Flotte TR, Humphries M, Calcedo R, Hauswirth WW, Chulay JD, Stout JT. Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood-Onset Retinal Dystrophy. Ophthalmology. PMID 27102010 DOI: 10.1016/J.Ophtha.2016.03.003 |
0.452 |
|
| 2015 |
Sharma S, Mishra R, Walker BL, Deshmukh S, Zampino M, Patel J, Anamalai M, Simpson D, Singh IS, Kaushal S, Kaushal S. Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death. Cell Stress & Chaperones. 20: 185-201. PMID 25300203 DOI: 10.1007/S12192-014-0536-1 |
0.316 |
|
| 2014 |
Tam BM, Noorwez SM, Kaushal S, Kono M, Moritz OL. Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13336-48. PMID 25274813 DOI: 10.1523/Jneurosci.1655-14.2014 |
0.474 |
|
| 2013 |
Byrne M, Tzekov R, Wang Y, Rodgers A, Cardia J, Ford G, Holton K, Pandarinathan L, Lapierre J, Stanney W, Bulock K, Shaw S, Libertine L, Fettes K, Khvorova A, ... Kaushal S, et al. Novel hydrophobically modified asymmetric RNAi compounds (sd-rxRNA) demonstrate robust efficacy in the eye. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 29: 855-64. PMID 24180627 DOI: 10.1089/Jop.2013.0148 |
0.361 |
|
| 2013 |
Lei L, Tzekov R, McDowell JH, Smith WC, Tang S, Kaushal S. Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments. Experimental Eye Research. 112: 57-67. PMID 23603319 DOI: 10.1016/J.Exer.2013.04.006 |
0.418 |
|
| 2012 |
Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, ... ... Kaushal S, et al. Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Archives of Ophthalmology (Chicago, Ill. : 1960). 130: 9-24. PMID 21911650 DOI: 10.1001/Archophthalmol.2011.298 |
0.442 |
|
| 2011 |
Hulleman JD, Kaushal S, Balch WE, Kelly JW. Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration. Molecular Biology of the Cell. 22: 4765-75. PMID 22031286 DOI: 10.1091/Mbc.E11-08-0695 |
0.361 |
|
| 2011 |
Xia H, Krebs MP, Kaushal S, Scott EW. Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice. Experimental Eye Research. 93: 862-72. PMID 21989111 DOI: 10.1016/J.Exer.2011.09.020 |
0.438 |
|
| 2011 |
Tzekov R, Stein L, Kaushal S. Protein misfolding and retinal degeneration. Cold Spring Harbor Perspectives in Biology. 3: a007492. PMID 21825021 DOI: 10.1101/Cshperspect.A007492 |
0.491 |
|
| 2011 |
Stein L, Roy K, Lei L, Kaushal S. Clinical gene therapy for the treatment of RPE65-associated Leber congenital amaurosis. Expert Opinion On Biological Therapy. 11: 429-39. PMID 21299439 DOI: 10.1517/14712598.2011.557358 |
0.41 |
|
| 2011 |
Clemson CM, Tzekov R, Krebs M, Checchi JM, Bigelow C, Kaushal S. Therapeutic potential of valproic acid for retinitis pigmentosa British Journal of Ophthalmology. 95: 89-93. PMID 20647559 DOI: 10.1136/Bjo.2009.175356 |
0.372 |
|
| 2010 |
Malhotra R, Kapoor A, Grover V, Kaushal S. Nicotine and periodontal tissues. Journal of Indian Society of Periodontology. 14: 72-9. PMID 20922084 DOI: 10.4103/0972-124X.65442 |
0.66 |
|
| 2010 |
Kaushal S, Annamali M, Blomenkamp K, Rudnick D, Halloran D, Brunt EM, Teckman JH. Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model. Experimental Biology and Medicine (Maywood, N.J.). 235: 700-9. PMID 20511674 DOI: 10.1258/Ebm.2010.009297 |
0.314 |
|
| 2010 |
Krebs MP, Holden DC, Joshi P, Clark CL, Lee AH, Kaushal S. Molecular mechanisms of rhodopsin retinitis pigmentosa and the efficacy of pharmacological rescue. Journal of Molecular Biology. 395: 1063-78. PMID 19913029 DOI: 10.1016/J.Jmb.2009.11.015 |
0.5 |
|
| 2009 |
Noorwez SM, Sama RR, Kaushal S. Calnexin improves the folding efficiency of mutant rhodopsin in the presence of pharmacological chaperone 11-cis-retinal. The Journal of Biological Chemistry. 284: 33333-42. PMID 19801547 DOI: 10.1074/Jbc.M109.043364 |
0.431 |
|
| 2009 |
Cideciyan AV, Hauswirth WW, Aleman TS, Kaushal S, Schwartz SB, Boye SL, Windsor EA, Conlon TJ, Sumaroka A, Roman AJ, Byrne BJ, Jacobson SG. Vision 1 year after gene therapy for Leber's congenital amaurosis. The New England Journal of Medicine. 361: 725-7. PMID 19675341 DOI: 10.1056/Nejmc0903652 |
0.373 |
|
| 2009 |
Cideciyan AV, Hauswirth WW, Aleman TS, Kaushal S, Schwartz SB, Boye SL, Windsor EA, Conlon TJ, Sumaroka A, Pang JJ, Roman AJ, Byrne BJ, Jacobson SG. Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year. Human Gene Therapy. 20: 999-1004. PMID 19583479 DOI: 10.1089/Hum.2009.086 |
0.437 |
|
| 2009 |
Welch DE, Elmariah H, Peden MC, Adams SG, Ratnakaram R, Kaushal S. Short-term response of macular oedema to intravitreal bevacizumab. The British Journal of Ophthalmology. 93: 1033-6. PMID 19403519 DOI: 10.1136/Bjo.2008.148874 |
0.336 |
|
| 2009 |
Swindle-Reilly KE, Shah M, Hamilton PD, Eskin TA, Kaushal S, Ravi N. Rabbit study of an in situ forming hydrogel vitreous substitute. Investigative Ophthalmology & Visual Science. 50: 4840-6. PMID 19324846 DOI: 10.1167/Iovs.08-2891 |
0.326 |
|
| 2009 |
Krebs MP, White DA, Kaushal S. Biphasic photoreceptor degeneration induced by light in a T17M rhodopsin mouse model of cone bystander damage. Investigative Ophthalmology & Visual Science. 50: 2956-65. PMID 19136713 DOI: 10.1167/Iovs.08-3116 |
0.454 |
|
| 2009 |
Harris JR, Fisher R, Jorgensen M, Kaushal S, Scott EW. CD133 progenitor cells from the bone marrow contribute to retinal pigment epithelium repair. Stem Cells (Dayton, Ohio). 27: 457-66. PMID 19038791 DOI: 10.1634/Stemcells.2008-0836 |
0.389 |
|
| 2008 |
Cideciyan AV, Aleman TS, Boye SL, Schwartz SB, Kaushal S, Roman AJ, Pang JJ, Sumaroka A, Windsor EA, Wilson JM, Flotte TR, Fishman GA, Heon E, Stone EM, Byrne BJ, et al. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proceedings of the National Academy of Sciences of the United States of America. 105: 15112-7. PMID 18809924 DOI: 10.1073/Pnas.0807027105 |
0.454 |
|
| 2008 |
Hauswirth WW, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, Conlon TJ, Boye SL, Flotte TR, Byrne BJ, Jacobson SG. Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Human Gene Therapy. 19: 979-90. PMID 18774912 DOI: 10.1089/Hum.2008.107 |
0.474 |
|
| 2008 |
Aleman TS, Cideciyan AV, Sumaroka A, Windsor EA, Herrera W, White DA, Kaushal S, Naidu A, Roman AJ, Schwartz SB, Stone EM, Jacobson SG. Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations. Investigative Ophthalmology & Visual Science. 49: 1580-90. PMID 18385078 DOI: 10.1167/Iovs.07-1110 |
0.487 |
|
| 2008 |
Noorwez SM, Ostrov DA, McDowell JH, Krebs MP, Kaushal S. A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin. Investigative Ophthalmology & Visual Science. 49: 3224-30. PMID 18378578 DOI: 10.1167/Iovs.07-1539 |
0.319 |
|
| 2008 |
Cunningham MA, Edelman JL, Kaushal S. Intravitreal steroids for macular edema: the past, the present, and the future. Survey of Ophthalmology. 53: 139-49. PMID 18348879 DOI: 10.1016/J.Survophthal.2007.12.005 |
0.416 |
|
| 2008 |
Hauswirth W, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, Conlon T, Boye SL, Flotte TR, Byrne B, Jacobson SG. Phase I Trial of Leber Congenital Amaurosis due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results Human Gene Therapy. 81015093227032. DOI: 10.1089/Hgt.2008.107 |
0.32 |
|
| 2006 |
Kaushal S. Effect of rapamycin on the fate of P23H opsin associated with retinitis pigmentosa (an American Ophthalmological Society thesis). Transactions of the American Ophthalmological Society. 104: 517-29. PMID 17471359 |
0.354 |
|
| 2006 |
Jacobson SG, Boye SL, Aleman TS, Conlon TJ, Zeiss CJ, Roman AJ, Cideciyan AV, Schwartz SB, Komaromy AM, Doobrajh M, Cheung AY, Sumaroka A, Pearce-Kelling SE, Aguirre GD, Kaushal S, et al. Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Human Gene Therapy. 17: 845-58. PMID 16942444 DOI: 10.1089/Hum.2006.17.845 |
0.479 |
|
| 2006 |
Nusinowitz S, Ridder WH, Pang JJ, Chang B, Noorwez SM, Kaushal S, Hauswirth WW, Heckenlively JR. Cortical visual function in the rd12 mouse model of Leber Congenital Amarousis (LCA) after gene replacement therapy to restore retinal function. Vision Research. 46: 3926-34. PMID 16814838 DOI: 10.1016/J.Visres.2006.05.010 |
0.427 |
|
| 2006 |
Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Schwartz SB, Cideciyan AV, Zeiss CJ, Komaromy AM, Kaushal S, Roman AJ, Windsor EA, Sumaroka A, Pearce-Kelling SE, Conlon TJ, Chiodo VA, et al. Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1074-84. PMID 16644289 DOI: 10.1016/J.Ymthe.2006.03.005 |
0.399 |
|
| 2006 |
Harris JR, Brown GA, Jorgensen M, Kaushal S, Ellis EA, Grant MB, Scott EW. Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury. Investigative Ophthalmology & Visual Science. 47: 2108-13. PMID 16639022 DOI: 10.1167/Iovs.05-0928 |
0.379 |
|
| 2006 |
Pang JJ, Chang B, Kumar A, Nusinowitz S, Noorwez SM, Li J, Rani A, Foster TC, Chiodo VA, Doyle T, Li H, Malhotra R, Teusner JT, McDowell JH, Min SH, ... ... Kaushal S, et al. Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 565-72. PMID 16223604 DOI: 10.1016/J.Ymthe.2005.09.001 |
0.733 |
|
| 2005 |
Pang JJ, Chang B, Hawes NL, Hurd RE, Davisson MT, Li J, Noorwez SM, Malhotra R, McDowell JH, Kaushal S, Hauswirth WW, Nusinowitz S, Thompson DA, Heckenlively JR. Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA). Molecular Vision. 11: 152-62. PMID 15765048 |
0.716 |
|
| 2004 |
Krebs MP, Noorwez SM, Malhotra R, Kaushal S. Quality control of integral membrane proteins. Trends in Biochemical Sciences. 29: 648-55. PMID 15544951 DOI: 10.1016/J.Tibs.2004.10.009 |
0.671 |
|
| 2004 |
Noorwez SM, Malhotra R, McDowell JH, Smith KA, Krebs MP, Kaushal S. Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H. The Journal of Biological Chemistry. 279: 16278-84. PMID 14769795 DOI: 10.1074/Jbc.M312101200 |
0.718 |
|
| 2003 |
Noorwez SM, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, Kaushal S. Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa. The Journal of Biological Chemistry. 278: 14442-50. PMID 12566452 DOI: 10.1074/Jbc.M300087200 |
0.515 |
|
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