| Year |
Citation |
Score |
| 2020 |
Yang BC, Wu SY, Leung PS. Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance. Annals of Translational Medicine. 8: 310. PMID 32355754 DOI: 10.21037/Atm.2020.02.129 |
0.361 |
|
| 2019 |
Xie T, So WY, Li XY, Leung PS. Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism. Clinical Science (London, England : 1979). 133: 2029-2044. PMID 31654570 DOI: 10.1042/Cs20190093 |
0.391 |
|
| 2019 |
Li XY, Wu SY, Leung PS. Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters. International Journal of Molecular Sciences. 20. PMID 31438545 DOI: 10.3390/Ijms20174083 |
0.349 |
|
| 2019 |
Wu SY, Liang J, Yang BC, Leung PS. SIRT1 Activation Promotes β-cell Regeneration by Activating Endocrine Progenitor Cells via AMPK Signaling-mediated Fatty Acid Oxidation. Stem Cells (Dayton, Ohio). PMID 31400234 DOI: 10.1002/Stem.3073 |
0.37 |
|
| 2019 |
Leung PS. The Modulatory Action of Vitamin D on the Renin-Angiotensin System and the Determination of Hepatic Insulin Resistance. Molecules (Basel, Switzerland). 24. PMID 31284538 DOI: 10.3390/Molecules24132479 |
0.347 |
|
| 2019 |
Cheng STW, Li SYT, Leung PS. Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling. International Journal of Molecular Sciences. 20. PMID 31121855 DOI: 10.3390/Ijms20102517 |
0.374 |
|
| 2019 |
Leung PS. FGF21 activation-mediated islet autophagy in Type 2 diabetes with pharmacotherapeutic potential. Future Medicinal Chemistry. PMID 30920304 DOI: 10.4155/Fmc-2018-0491 |
0.325 |
|
| 2018 |
Wang Y, Xie T, Zhang D, Leung PS. GPR120 protects lipotoxicity-induced pancreatic beta-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation. Clinical Science (London, England : 1979). PMID 30523046 DOI: 10.1042/Cs20180836 |
0.395 |
|
| 2018 |
Zhang D, Xie T, Leung PS. Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 51: 924-937. PMID 30466091 DOI: 10.1159/000495395 |
0.339 |
|
| 2017 |
Lai ZQ, Ip SP, Liao HJ, Lu Z, Xie JH, Su ZR, Chen YL, Xian YF, Leung PS, Lin ZX. Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway. Frontiers in Pharmacology. 8: 936. PMID 29311937 DOI: 10.3389/Fphar.2017.00936 |
0.327 |
|
| 2017 |
Lu Z, Lai ZQ, Leung AWN, Leung PS, Li ZS, Lin ZX. Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies. Oncotarget. 8: 84974-84985. PMID 29156697 DOI: 10.18632/Oncotarget.17761 |
0.348 |
|
| 2017 |
Chan LKY, Wang Y, Ng EKW, Leung PS. NHE3 Blockade Ameliorates Type 2 Diabetes Mellitus via Inhibition of SGLT1-Mediated Glucose Absorption in the Small Intestine. Diabetes, Obesity & Metabolism. PMID 29110392 DOI: 10.1111/Dom.13151 |
0.319 |
|
| 2017 |
Xie T, Leung PS. Fibroblast growth factor 21: a regulator of metabolic disease and health span. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00101.2017. PMID 28559437 DOI: 10.1152/Ajpendo.00101.2017 |
0.317 |
|
| 2017 |
Ting Li SY, Wai Cheng ST, Zhang D, Leung PS. Identification and Functional Implications of Sodium/Myo-inositol Cotransporter 1 in Pancreatic Beta-cells and Type 2 Diabetes Mellitus. Diabetes. PMID 28202581 DOI: 10.2337/Db16-0880 |
0.42 |
|
| 2017 |
Wang L, Wang Y, Li XY, Leung PS. Angiotensin II Type 2 Receptor Activation With Compound 21 Augments Islet Function and Regeneration in Streptozotocin-Induced Neonatal Rats and Human Pancreatic Progenitor Cells. Pancreas. PMID 28099262 DOI: 10.1097/Mpa.0000000000000754 |
0.397 |
|
| 2016 |
Zhang D, So WY, Wang Y, Wu SY, Cheng Q, Leung PS. Insulinotropic effects of GPR120 agonists are altered in obese non-diabetic and diabetic states. Clinical Science (London, England : 1979). PMID 27980130 DOI: 10.1042/Cs20160545 |
0.392 |
|
| 2016 |
Cheng S, So WY, Zhang D, Cheng Q, Boucher BJ, Leung PS. Calcitriol reduces hepatic triglyceride accumulation and glucose output through Ca2+/CaMKKβ/AMPK activation under insulin-resistant conditions in type 2 diabetes mellitus. Current Molecular Medicine. PMID 27658467 DOI: 10.2174/1566524016666160920111407 |
0.327 |
|
| 2016 |
So WY, Leung PS. Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling. The International Journal of Biochemistry & Cell Biology. PMID 27452313 DOI: 10.1016/J.Biocel.2016.07.022 |
0.343 |
|
| 2016 |
Lu S, Chow CC, Zhou J, Leung PS, Tsui SK, Lui KO. Genetic Modification of Human Pancreatic Progenitor Cells Through Modified mRNA. Methods in Molecular Biology (Clifton, N.J.). 1428: 307-317. PMID 27236809 DOI: 10.1007/978-1-4939-3625-0_21 |
0.333 |
|
| 2016 |
So WY, Leung PS. Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus. Medicinal Research Reviews. PMID 27031294 DOI: 10.1002/Med.21390 |
0.319 |
|
| 2016 |
Cheng ST, Chen L, Li SY, Mayoux E, Leung PS. The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes. Plos One. 11: e0147391. PMID 26807719 DOI: 10.1371/Journal.Pone.0147391 |
0.405 |
|
| 2016 |
Leung PS. The potential protective action of vitamin D in hepatic insulin resistance and pancreatic islet dysfunction in type 2 diabetes mellitus Nutrients. 8. DOI: 10.3390/Nu8030147 |
0.361 |
|
| 2015 |
Zhao S, Chan LK, Chen L, Cheng TW, Klein T, Leung PS. Combination of Telmisartan and Linagliptin Preserves Pancreatic Islet Cell Function and Morphology in db/db Mice. Pancreas. PMID 26495783 DOI: 10.1097/Mpa.0000000000000505 |
0.373 |
|
| 2015 |
Chan LK, Leung PS. Multifaceted interplay among mediators and regulators of intestinal glucose absorption: Potential impacts on diabetes research and treatment. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00373.2015. PMID 26487007 DOI: 10.1152/Ajpendo.00373.2015 |
0.329 |
|
| 2015 |
Liang J, Wu SY, Zhang D, Wang L, Leung KK, Leung PS. NADPH Oxidase-Dependent Reactive Oxygen Species Stimulate β-Cell Regeneration through Differentiation of Endocrine Progenitors in Murine Pancreas. Antioxidants & Redox Signaling. PMID 26464216 DOI: 10.1089/Ars.2014.6135 |
0.316 |
|
| 2015 |
Wong TP, Chan LK, Leung PS. Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice. Nutrients. 7: 7543-61. PMID 26371038 DOI: 10.3390/Nu7095352 |
0.355 |
|
| 2015 |
Wang L, Liang J, Leung PS. The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos. Plos One. 10: e0128216. PMID 26029927 DOI: 10.1371/Journal.Pone.0128216 |
0.443 |
|
| 2015 |
So WY, Cheng Q, Xu A, Lam KS, Leung PS. Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice. Cell Death & Disease. 6: e1707. PMID 25811804 DOI: 10.1038/Cddis.2015.80 |
0.383 |
|
| 2015 |
Chen L, So WY, Li SY, Cheng Q, Boucher BJ, Leung PS. Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. Molecular and Cellular Endocrinology. 404: 56-66. PMID 25622782 DOI: 10.1016/J.Mce.2015.01.029 |
0.419 |
|
| 2014 |
Zhang D, Leung PS. Potential roles of GPR120 and its agonists in the management of diabetes Drug Design Development and Therapy. 8: 1013-1027. PMID 25114508 DOI: 10.2147/Dddt.S53892 |
0.378 |
|
| 2014 |
Li L, Yue GG, Pu JX, Sun HD, Fung KP, Leung PC, Han QB, Lau CB, Leung PS. Eriocalyxin B-induced apoptosis in pancreatic adenocarcinoma cells through thiol-containing antioxidant systems and downstream signalling pathways. Current Molecular Medicine. 14: 673-89. PMID 24894173 DOI: 10.2174/1566524014666140603102459 |
0.348 |
|
| 2014 |
Li L, Leung PS. Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer. The International Journal of Biochemistry & Cell Biology. 53: 224-236. PMID 24875648 DOI: 10.1016/J.Biocel.2014.05.021 |
0.315 |
|
| 2014 |
Liang J, Ng KY, Cheng Q, Xia Y, Wang CC, Leung PS. Human fetal liver stromal cell co-culture enhances the differentiation of pancreatic progenitor cells into islet-like cell clusters. Stem Cell Reviews. 10: 280-94. PMID 24395006 DOI: 10.1007/S12015-013-9491-Y |
0.362 |
|
| 2014 |
Leung KK, Liang J, Zhao S, Chan WY, Leung PS. Angiotensin II type 2 receptor regulates the development of pancreatic endocrine cells in mouse embryos. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 243: 415-27. PMID 24166718 DOI: 10.1002/Dvdy.24084 |
0.409 |
|
| 2014 |
Lam SY, Liu Y, Ng KM, Liong EC, Tipoe GL, Leung PS, Fung ML. Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia. Experimental Physiology. 99: 220-31. PMID 24036592 DOI: 10.1113/Expphysiol.2013.074591 |
0.371 |
|
| 2013 |
Wang L, Leung PS. The role of renin-angiotensin system in cellular differentiation: implications in pancreatic islet cell development and islet transplantation. Molecular and Cellular Endocrinology. 381: 261-271. PMID 23994025 DOI: 10.1016/J.Mce.2013.08.008 |
0.41 |
|
| 2013 |
So WY, Cheng Q, Chen L, Evans-Molina C, Xu A, Lam KS, Leung PS. High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signaling. Diabetes. 62: 3751-9. PMID 23897951 DOI: 10.2337/Db13-0645 |
0.393 |
|
| 2013 |
Chen LH, Leung PS. Inhibition of the sodium glucose co-transporter-2: its beneficial action and potential combination therapy for type 2 diabetes mellitus. Diabetes, Obesity and Metabolism. 15: 392-402. PMID 23331516 DOI: 10.1111/Dom.12064 |
0.341 |
|
| 2013 |
Cheng Q, Boucher BJ, Leung PS. Modulation of hypovitaminosis D-induced islet dysfunction and insulin resistance through direct suppression of the pancreatic islet renin–angiotensin system in mice Diabetologia. 56: 553-562. PMID 23250033 DOI: 10.1007/S00125-012-2801-0 |
0.365 |
|
| 2012 |
Wong TP, Ho KY, Ng EK, Debnam ES, Leung PS. Upregulation of ACE2-ANG-(1-7)-Mas axis in jejunal enterocytes of type 1 diabetic rats: implications for glucose transport. American Journal of Physiology. Endocrinology and Metabolism. 303: E669-81. PMID 22811473 DOI: 10.1152/Ajpendo.00562.2011 |
0.407 |
|
| 2012 |
Chen L, Klein T, Leung PS. Effects of combining linagliptin treatment with BI-38335, a novel SGLT2 inhibitor, on pancreatic islet function and inflammation in db/db mice. Current Molecular Medicine. 12: 995-1004. PMID 22804249 DOI: 10.2174/156652412802480970 |
0.391 |
|
| 2012 |
Li L, Yue GG, Lau CB, Sun H, Fung KP, Leung PC, Han Q, Leung PS. Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways. Toxicology and Applied Pharmacology. 262: 80-90. PMID 22561874 DOI: 10.1016/J.Taap.2012.04.021 |
0.358 |
|
| 2012 |
Liu L, Lin ZX, Leung PS, Chen LH, Zhao M, Liang J. Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells. International Journal of Molecular Medicine. 30: 93-9. PMID 22552257 DOI: 10.3892/Ijmm.2012.980 |
0.353 |
|
| 2012 |
Liang J, Leung KK, Lam SY, Leung PS. Combined treatment with a dipeptidyl peptidase-IV inhibitor (sitagliptin) and an angiotensin II type 1 receptor blocker (losartan) promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells. Diabetes, Obesity & Metabolism. 14: 842-51. PMID 22519909 DOI: 10.1111/J.1463-1326.2012.01612.X |
0.443 |
|
| 2012 |
Leung KK, Liang J, Ma MT, Leung PS. Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation. Stem Cells (Dayton, Ohio). 30: 525-36. PMID 22162314 DOI: 10.1002/Stem.1008 |
0.425 |
|
| 2012 |
Leung PS, Ng KY. Current progress in stem cell research and its potential for islet cell transplantation. Current Molecular Medicine. 13: 109-125. DOI: 10.2174/1566524011307010109 |
0.345 |
|
| 2011 |
Skipworth JR, Szabadkai G, Olde Damink SW, Leung PS, Humphries SE, Montgomery HE. Review article: pancreatic renin-angiotensin systems in health and disease. Alimentary Pharmacology & Therapeutics. 34: 840-52. PMID 21851372 DOI: 10.1111/J.1365-2036.2011.04810.X |
0.392 |
|
| 2011 |
Chan YC, Leung PS. The renin-angiotensin system and reactive oxygen species: Implications in pancreatitis Antioxidants and Redox Signaling. 15: 2743-2755. PMID 21644836 DOI: 10.1089/Ars.2011.4071 |
0.398 |
|
| 2011 |
Zhao M, Lau ST, Leung PS, Che CT, Lin ZX. Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines. Phytotherapy Research. 25: 1796-1800. PMID 21480411 DOI: 10.1002/Ptr.3477 |
0.301 |
|
| 2011 |
Cheng Q, Li YC, Boucher BJ, Leung PS. A novel role for vitamin D: Modulation of expression and function of the local renin-angiotensin system in mouse pancreatic islets Diabetologia. 54: 2077-2081. PMID 21424540 DOI: 10.1007/S00125-011-2100-1 |
0.391 |
|
| 2011 |
Cheng Q, Leung PS. An update on the islet renin-angiotensin system. Peptides. 32: 1087-95. PMID 21396973 DOI: 10.1016/J.Peptides.2011.03.003 |
0.398 |
|
| 2011 |
Lau ST, Leung PS. Role of the RAS in pancreatic cancer. Current Cancer Drug Targets. 11: 412-420. PMID 21395550 DOI: 10.2174/156800911795538110 |
0.382 |
|
| 2011 |
Ma MT, Leung KK, Tsang KS, Leung PS. Reduced immunogenicity of pancreatic progenitor cells derived from first-trimester human fetal pancreas. The International Journal of Biochemistry & Cell Biology. 43: 812-20. PMID 21352950 DOI: 10.1016/J.Biocel.2011.02.006 |
0.383 |
|
| 2011 |
Chan YC, Leung PS. Co-operative effects of angiotensin II and caerulein in NFκB activation in pancreatic acinar cells in vitro Regulatory Peptides. 166: 128-134. PMID 20959124 DOI: 10.1016/J.Regpep.2010.10.006 |
0.409 |
|
| 2011 |
Cui J, Wang Z, Cheng Q, Lin R, Zhang XM, Leung PS, Copeland NG, Jenkins NA, Yao KM, Huang JD. Targeted inactivation of kinesin-1 in pancreatic β-cells in vivo leads to insulin secretory deficiency. Diabetes. 60: 320-30. PMID 20870970 DOI: 10.2337/Db09-1078 |
0.371 |
|
| 2011 |
Ng KY, Ma MT, Leung KK, Leung PS. Vitamin D and vitamin A receptor expression and the proliferative effects of ligand activation of these receptors on the development of pancreatic progenitor cells derived from human fetal pancreas. Stem Cell Reviews. 7: 53-63. PMID 20354914 DOI: 10.1007/S12015-010-9146-1 |
0.38 |
|
| 2010 |
Leung PS. Current Research of the RAS in Pancreatitis and Pancreatic Cancer Advances in Experimental Medicine and Biology. 690: 179-199. PMID 20700843 DOI: 10.1007/978-90-481-9060-7_10 |
0.394 |
|
| 2010 |
Leung PS. Current Research Concerning the RAS in Pancreatic Stem Cells Advances in Experimental Medicine and Biology. 690: 155-177. PMID 20700842 DOI: 10.1007/978-90-481-9060-7_9 |
0.384 |
|
| 2010 |
Leung PS. Current research of the RAS in diabetes mellitus. Advances in Experimental Medicine and Biology. 690: 131-153. PMID 20700841 DOI: 10.1007/978-90-481-9060-7_8 |
0.381 |
|
| 2010 |
Leung PS. Basic Techniques for Pancreatic Research Advances in Experimental Medicine and Biology. 690: 109-130. PMID 20700840 DOI: 10.1007/978-90-481-9060-7_7 |
0.333 |
|
| 2010 |
Leung PS. Common pancreatic disease. Advances in Experimental Medicine and Biology. 690: 29-51. PMID 20700836 DOI: 10.1007/978-90-481-9060-7_3 |
0.331 |
|
| 2010 |
Leung PS. Physiology of the Pancreas Advances in Experimental Medicine and Biology. 690: 13-27. PMID 20700835 DOI: 10.1007/978-90-481-9060-7_2 |
0.36 |
|
| 2010 |
Leung PS. Overview of the pancreas. Advances in Experimental Medicine and Biology. 690: 3-12. PMID 20700834 DOI: 10.1007/978-90-481-9060-7_1 |
0.391 |
|
| 2010 |
Leung PS, Cheng Q. The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function. Advances in Experimental Medicine and Biology. 654: 339-61. PMID 20217505 DOI: 10.1007/978-90-481-3271-3_15 |
0.421 |
|
| 2010 |
Tsang SW, Shao D, Cheah KSE, Okuse K, Leung PS, Yao KM. Increased basal insulin secretion in Pdzd2-deficient mice Molecular and Cellular Endocrinology. 315: 263-270. PMID 19932150 DOI: 10.1016/J.Mce.2009.11.007 |
0.374 |
|
| 2010 |
Chu KY, Cheng Q, Chen C, Au LS, Seto SW, Tuo Y, Motin L, Kwan YW, Leung PS. Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta-cells via angiotensin II type 2 receptors. American Journal of Physiology. Cell Physiology. 298: C313-23. PMID 19889960 DOI: 10.1152/Ajpcell.00575.2008 |
0.354 |
|
| 2009 |
Wong TP, Debnam ES, Leung PS. Diabetes mellitus and expression of the enterocyte renin-angiotensin system: implications for control of glucose transport across the brush border membrane. American Journal of Physiology. Cell Physiology. 297: C601-10. PMID 19535516 DOI: 10.1152/Ajpcell.00135.2009 |
0.37 |
|
| 2009 |
Lau ST, Lin ZX, Liao Y, Zhao M, Cheng CH, Leung PS. Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase. Cancer Letters. 281: 42-52. PMID 19286308 DOI: 10.1016/J.Canlet.2009.02.017 |
0.355 |
|
| 2009 |
Chu KY, Leung PS. Angiotensin II in type 2 diabetes mellitus. Current Protein & Peptide Science. 10: 75-84. PMID 19275674 DOI: 10.2174/138920309787315176 |
0.381 |
|
| 2009 |
Thomas MK, Tsang SW, Yeung ML, Leung PS, Yao KM. The roles of the PDZ-containing proteins bridge-1 and PDZD2 in the regulation of insulin production and pancreatic beta-cell mass. Current Protein & Peptide Science. 10: 30-6. PMID 19275670 DOI: 10.2174/138920309787315248 |
0.37 |
|
| 2009 |
Chan YC, Leung PS. Involvement of redox-sensitive extracellular-regulated kinases in angiotensin II-induced interleukin-6 expression in pancreatic acinar cells Journal of Pharmacology and Experimental Therapeutics. 329: 450-458. PMID 19211919 DOI: 10.1124/Jpet.108.148353 |
0.359 |
|
| 2009 |
Leung KK, Suen PM, Lau TK, Ko WH, Yao KM, Leung PS. PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization. Stem Cells and Development. 18: 979-90. PMID 19046020 DOI: 10.1089/Scd.2008.0325 |
0.39 |
|
| 2009 |
Leung PS, Chan YC. Role of oxidative stress in pancreatic inflammation Antioxidants and Redox Signaling. 11: 135-165. PMID 18837654 DOI: 10.1089/Ars.2008.2109 |
0.322 |
|
| 2008 |
Cheng Q, Law PK, de Gasparo M, Leung PS. Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-L-valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes. The Journal of Pharmacology and Experimental Therapeutics. 327: 683-91. PMID 18787107 DOI: 10.1124/Jpet.108.142703 |
0.419 |
|
| 2008 |
Sin TL, Lin ZX, Zhao M, Leung PS. Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines Phytotherapy Research. 22: 477-486. PMID 18386257 DOI: 10.1002/Ptr.2344 |
0.321 |
|
| 2008 |
Suen PM, Zou C, Zhang YA, Lau TK, Chan J, Yao KM, Leung PS. PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells. The International Journal of Biochemistry & Cell Biology. 40: 789-803. PMID 18037333 DOI: 10.1016/J.Biocel.2007.10.020 |
0.385 |
|
| 2007 |
Fung ML, Lam SY, Wong TP, Tjong YW, Leung PS. Carotid Body AT(4) Receptor Expression and its Upregulation in Chronic Hypoxia. The Open Cardiovascular Medicine Journal. 1: 1-7. PMID 18949084 DOI: 10.2174/1874192400701010001 |
0.336 |
|
| 2007 |
Lai KC, Cheng CH, Leung PS. The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas. Pancreas. 35: e1-8. PMID 17895831 DOI: 10.1097/Mpa.0B0013E31812Eee3E |
0.413 |
|
| 2007 |
Wong TP, Debnam ES, Leung PS. Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane. The Journal of Physiology. 584: 613-23. PMID 17702818 DOI: 10.1113/Jphysiol.2007.138578 |
0.365 |
|
| 2007 |
Chan YC, Leung PS. Angiotensin II Type 1 Receptor-Dependent Nuclear Factor-κB Activation-Mediated Proinflammatory Actions in a Rat Model of Obstructive Acute Pancreatitis Journal of Pharmacology and Experimental Therapeutics. 323: 10-18. PMID 17616560 DOI: 10.1124/Jpet.107.124891 |
0.354 |
|
| 2007 |
Leung PS. Mechanisms of protective effects induced by blockade of the renin-angiotensin system: novel role of the pancreatic islet angiotensin-generating system in Type 2 diabetes. Diabetic Medicine. 24: 110-116. PMID 17257271 DOI: 10.1111/J.1464-5491.2007.02072.X |
0.413 |
|
| 2007 |
Leung PS. The physiology of a local renin-angiotensin system in the pancreas. The Journal of Physiology. 580: 31-37. PMID 17218353 DOI: 10.1113/Jphysiol.2006.126193 |
0.458 |
|
| 2007 |
Chan YC, Leung PS. Acute pancreatitis: Animal models and recent advances in basic research Pancreas. 34: 1-14. PMID 17198179 DOI: 10.1097/01.Mpa.0000246658.38375.04 |
0.312 |
|
| 2007 |
Li JM, Che CT, Lau CB, Leung PS, Cheng CH. Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) inhibits glucose uptake in the intestine and kidney: In vitro and in vivo studies. The Journal of Pharmacology and Experimental Therapeutics. 320: 38-46. PMID 17038511 DOI: 10.1124/Jpet.106.111526 |
0.324 |
|
| 2006 |
Leung PS, Gasparo Md. Involvement of the pancreatic renin-angiotensin system in insulin resistance and the metabolic syndrome. Journal of the Cardiometabolic Syndrome. 1: 197-203. PMID 17679833 DOI: 10.1111/J.1559-4564.2006.05460.X |
0.401 |
|
| 2006 |
Zhao Y, Shen S, Guo J, Chen H, Greenblatt DY, Kleeff J, Liao Q, Chen G, Friess H, Leung PS. Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells. Journal of Surgical Research. 136: 325-335. PMID 17054996 DOI: 10.1016/J.Jss.2006.06.031 |
0.332 |
|
| 2006 |
Leung PS. Novel roles of a local angiotensin-generating system in the carotid body. The Journal of Physiology. 575: 4-4. PMID 16809356 DOI: 10.1113/Jphysiol.2006.115550 |
0.372 |
|
| 2006 |
Yeung CM, Chan CB, Leung PS, Cheng CH. Cells of the anterior pituitary. The International Journal of Biochemistry & Cell Biology. 38: 1441-9. PMID 16621669 DOI: 10.1016/J.Biocel.2006.02.012 |
0.323 |
|
| 2006 |
Chu KY, Lau T, Carlsson P, Leung PS. Angiotensin II Type 1 Receptor Blockade Improves β-Cell Function and Glucose Tolerance in a Mouse Model of Type 2 Diabetes Diabetes. 55: 367-374. PMID 16443769 DOI: 10.2337/Diabetes.55.02.06.Db05-1022 |
0.406 |
|
| 2006 |
Chan YC, Leung PS. AT1 receptor antagonism ameliorates acute pancreatitis- associated pulmonary injury Regulatory Peptides. 134: 46-53. PMID 16443293 DOI: 10.1016/J.Regpep.2005.12.001 |
0.332 |
|
| 2006 |
Zou C, Suen PM, Zhang Y, Wang Z, Chan P, Leung PS, Zhang YA. Isolation and in vitro characterization of pancreatic progenitor cells from the islets of diabetic monkey models. The International Journal of Biochemistry & Cell Biology. 38: 973-84. PMID 16431150 DOI: 10.1016/J.Biocel.2005.12.012 |
0.392 |
|
| 2006 |
Leung PS, Ip SP. Pancreatic acinar cell: Its role in acute pancreatitis The International Journal of Biochemistry & Cell Biology. 38: 1024-1030. PMID 16423553 DOI: 10.1016/J.Biocel.2005.12.001 |
0.37 |
|
| 2006 |
Ma RY, Tam TS, Suen AP, Yeung PM, Tsang SW, Chung SK, Thomas MK, Leung PS, Yao KM. Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells. The International Journal of Biochemistry & Cell Biology. 38: 1015-22. PMID 16413998 DOI: 10.1016/J.Biocel.2005.11.012 |
0.373 |
|
| 2006 |
Li JM, Che CT, Lau CB, Leung PS, Cheng CH. Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin. The International Journal of Biochemistry & Cell Biology. 38: 985-95. PMID 16289850 DOI: 10.1016/J.Biocel.2005.10.002 |
0.305 |
|
| 2006 |
Suen PM, Li K, Chan JC, Leung PS. In vivo treatment with glucagon-like peptide 1 promotes the graft function of fetal islet-like cell clusters in transplanted mice. The International Journal of Biochemistry & Cell Biology. 38: 951-60. PMID 16172015 DOI: 10.1016/J.Biocel.2005.08.005 |
0.364 |
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| 2006 |
Chan YC, Leung PS. The Protective Effect Of At1 Receptor Blockade On Obstruction-Induced Acute Pancreatitis: Its Potential Mechanistic Pathways Pancreas. 33: 451. DOI: 10.1097/00006676-200611000-00054 |
0.343 |
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| 2005 |
Kampf C, Lau T, Olsson R, Leung PS, Carlsson P. Angiotensin II type 1 receptor inhibition markedly improves the blood perfusion, oxygen tension and first phase of glucose-stimulated insulin secretion in revascularised syngeneic mouse islet grafts. Diabetologia. 48: 1159-1167. PMID 15877216 DOI: 10.1007/S00125-005-1761-Z |
0.379 |
|
| 2005 |
Leung PS, Carlsson P. Pancreatic islet renin angiotensin system: its novel roles in islet function and in diabetes mellitus. Pancreas. 30: 293-298. PMID 15841036 DOI: 10.1097/01.Mpa.0000158028.76666.76 |
0.373 |
|
| 2005 |
Lai JK, Cheng CH, Ko WH, Leung PS. Ghrelin system in pancreatic AR42J cells: its ligand stimulation evokes calcium signalling through ghrelin receptors. The International Journal of Biochemistry & Cell Biology. 37: 887-900. PMID 15694847 DOI: 10.1016/J.Biocel.2004.11.012 |
0.355 |
|
| 2005 |
Chan VY, Chan MW, Leung WK, Leung PS, Sung JJ, Chan FK. Intestinal trefoil factor promotes invasion in non-tumorigenic Rat-2 fibroblast cell. Regulatory Peptides. 127: 87-94. PMID 15680474 DOI: 10.1016/J.Regpep.2004.10.016 |
0.328 |
|
| 2005 |
Leung PS. Roles of the renin-angiotensin system and its blockade in pancreatic inflammation. The International Journal of Biochemistry & Cell Biology. 37: 237-238. PMID 15381165 DOI: 10.1016/J.Biocel.2004.07.004 |
0.354 |
|
| 2004 |
Leung PS. The peptide hormone angiotensin II: its new functions in tissues and organs. Current Protein & Peptide Science. 5: 267-273. PMID 15320733 DOI: 10.2174/1389203043379693 |
0.346 |
|
| 2004 |
Tsang SW, Cheng CHK, Leung PS. The role of the pancreatic renin-angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis Regulatory Peptides. 119: 213-219. PMID 15120483 DOI: 10.1016/J.Regpep.2004.02.003 |
0.433 |
|
| 2004 |
Lau T, Carlsson P, Leung P. Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets Diabetologia. 47: 240-248. PMID 14722647 DOI: 10.1007/S00125-003-1295-1 |
0.39 |
|
| 2004 |
Tsang SW, Ip SP, Leung PS. Prophylactic and therapeutic treatments with AT1 and AT 2 receptor antagonists and their effects on changes in the severity of pancreatitis International Journal of Biochemistry and Cell Biology. 36: 330-339. PMID 14643897 DOI: 10.1016/S1357-2725(03)00257-7 |
0.384 |
|
| 2003 |
Ip SP, Wong TP, Tsai SJ, Leung PS. The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition. Journal of Molecular Endocrinology. 31: 563-71. PMID 14664716 DOI: 10.1677/Jme.0.0310563 |
0.381 |
|
| 2003 |
Leung PS, Suen PM, Ip SP, Yip CK, Chen G, Lai PB. Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response. Regulatory Peptides. 116: 61-9. PMID 14599716 DOI: 10.1016/S0167-0115(03)00192-7 |
0.391 |
|
| 2003 |
Leung P, Sernia C. The renin-angiotensin system and male reproduction: new functions for old hormones. Journal of Molecular Endocrinology. 30: 263-270. PMID 12790798 DOI: 10.1677/Jme.0.0300263 |
0.318 |
|
| 2003 |
Lam SY, Leung PS. Chronic hypoxia activates a local angiotensin-generating system in rat carotid body. Molecular and Cellular Endocrinology. 203: 147-53. PMID 12782411 DOI: 10.1016/S0303-7207(03)00087-X |
0.315 |
|
| 2003 |
Ip SP, Kwan PC, Williams CH, Pang S, Hooper NM, Leung PS. Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis. The International Journal of Biochemistry & Cell Biology. 35: 944-54. PMID 12676178 DOI: 10.1016/S1357-2725(02)00181-4 |
0.365 |
|
| 2003 |
Leung PS, Fung ML, Tam MSC. Renin-angiotensin system in the carotid body. The International Journal of Biochemistry & Cell Biology. 35: 847-854. PMID 12676171 DOI: 10.1016/S1357-2725(02)00180-2 |
0.333 |
|
| 2003 |
Leung PS, Chappell MC. A local pancreatic renin-angiotensin system: endocrine and exocrine roles. The International Journal of Biochemistry & Cell Biology. 35: 838-846. PMID 12676170 DOI: 10.1016/S1357-2725(02)00179-6 |
0.395 |
|
| 2003 |
Ip SP, Tsang SW, Wong TP, Che CT, Leung PS. Saralasin, a nonspecific angiotensin II receptor antagonist, attenuates oxidative stress and tissue injury in cerulein-induced acute pancreatitis. Pancreas. 26: 224-9. PMID 12657946 DOI: 10.1097/00006676-200304000-00003 |
0.353 |
|
| 2003 |
Tsang SW, Ip SP, Wong TP, Che CT, Leung PS. Differential effects of saralasin and ramiprilat, the inhibitors of renin-angiotensin system, on cerulein-induced acute pancreatitis. Regulatory Peptides. 111: 47-53. PMID 12609748 DOI: 10.1016/S0167-0115(02)00226-4 |
0.387 |
|
| 2002 |
Ip SP, Chan YW, Leung PS. Effects of chronic hypoxia on the circulating and pancreatic renin-angiotensin system. Pancreas. 25: 296-300. PMID 12370542 DOI: 10.1097/00006676-200210000-00013 |
0.371 |
|
| 2002 |
Lam SY, Leung PS. A locally generated angiotensin system in rat carotid body. Regulatory Peptides. 107: 97-103. PMID 12137971 DOI: 10.1016/S0167-0115(02)00068-X |
0.366 |
|
| 2002 |
Ip SP, Chan YW, Che CT, Leung PS. Effect of Chronic Hypoxia on Glutathione Status and Membrane Integrity in the Pancreas Pancreatology. 2: 34-39. PMID 12120004 DOI: 10.1159/000049446 |
0.31 |
|
| 2002 |
Cullinane AB, Leung PS, Ortego J, Coca-Prados M, Harvey BJ. Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium British Journal of Ophthalmology. 86: 676-683. PMID 12034692 DOI: 10.1136/Bjo.86.6.676 |
0.325 |
|
| 2002 |
M-L Fung, Lam SY, Dong X, Chen Y, Leung PS. Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors. The Journal of Endocrinology. 173: 305-13. PMID 12010638 DOI: 10.1677/Joe.0.1730305 |
0.344 |
|
| 2002 |
Lam KY, Leung PS. Regulation and expression of a renin-angiotensin system in human pancreas and pancreatic endocrine tumours European Journal of Endocrinology. 146: 567-572. PMID 11916627 DOI: 10.1530/Eje.0.1460567 |
0.371 |
|
| 2002 |
Leung PS, Wong TP, Chung YW, Chan HC. Androgen dependent expression of AT1 receptor and its regulation of anion secretion in rat epididymis. Cell Biology International. 26: 117-22. PMID 11779228 DOI: 10.1006/Cbir.2001.0830 |
0.354 |
|
| 2001 |
Leung PS, Tsai SJ, Wallukat G, Leung TN, Lau TK. The upregulation of angiotensin II receptor AT1 in human preeclamptic placenta Molecular and Cellular Endocrinology. 184: 95-102. PMID 11694345 DOI: 10.1016/S0303-7207(01)00637-2 |
0.352 |
|
| 2001 |
Yung WH, Leung PS, Ng SS, Zhang J, Chan SC, Chow BK. Secretin facilitates GABA transmission in the cerebellum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7063-8. PMID 11549716 DOI: 10.1523/Jneurosci.21-18-07063.2001 |
0.326 |
|
| 2001 |
Leung P, Carlsson P. Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas Journal of Molecular Endocrinology. 26: 155-164. PMID 11432370 DOI: 10.1677/Jme.0.0260155 |
0.382 |
|
| 2001 |
Leung PS, So SC, Lam SY, Tsang LL, Chung YW, Chan HC. Local regulation of anion secretion by pituitary adenylate cyclase-activating polypeptide in human colonic T84 cells. Cell Biology International. 25: 123-9. PMID 11237416 DOI: 10.1006/Cbir.2000.0584 |
0.329 |
|
| 2001 |
Fung ML, Lam SY, Chen Y, Dong X, Leung PS. Functional expression of angiotensin II receptors in type-I cells of the rat carotid body. PflüGers Archiv : European Journal of Physiology. 441: 474-80. PMID 11212210 DOI: 10.1007/S004240000445 |
0.346 |
|
| 2001 |
Leung P, Fung M, Sernia C. Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymis Regulatory Peptides. 96: 143-149. PMID 11111020 DOI: 10.1016/S0167-0115(00)00169-5 |
0.348 |
|
| 2000 |
Leung PS, Chan WP, Nobiling R. Regulated expression of pancreatic renin-angiotensin system in experimental pancreatitis. Molecular and Cellular Endocrinology. 166: 121-128. PMID 10996430 DOI: 10.1016/S0303-7207(00)00275-6 |
0.39 |
|
| 2000 |
Cheuk BL, Leung PS, Lo AC, Wong PY. Androgen control of cyclooxygenase expression in the rat epididymis. Biology of Reproduction. 63: 775-80. PMID 10952920 DOI: 10.1093/Biolreprod/63.3.775 |
0.306 |
|
| 2000 |
Leung PS, Wong TP, Lam SY, Chan HC, Wong PY. Testicular hormonal regulation of the renin-angiotensin system in the rat epididymis. Life Sciences. 66: 1317-24. PMID 10755467 DOI: 10.1016/S0024-3205(00)00439-2 |
0.353 |
|
| 2000 |
Chan WP, Fung ML, Nobiling R, Leung PS. Activation of local renin-angiotensin system by chronic hypoxia in rat pancreas. Molecular and Cellular Endocrinology. 160: 107-114. PMID 10715544 DOI: 10.1016/S0303-7207(99)00258-0 |
0.376 |
|
| 1999 |
Leung PS, Wong TP, Sernia C. Angiotensinogen expression by rat epididymis: evidence for an intrinsic, angiotensin-generating system. Molecular and Cellular Endocrinology. 155: 115-22. PMID 10580844 DOI: 10.1016/S0303-7207(99)00107-0 |
0.34 |
|
| 1999 |
Chan LN, Chung YW, Leung PS, Liu CQ, Chan HC. Activation of an adenosine 3',5'-cyclic monophosphate-dependent Cl- conductance in response to neurohormonal stimuli in mouse endometrial epithelial cells: The role of cystic fibrosis transmembrane conductance regulator Biology of Reproduction. 60: 374-380. PMID 9916004 DOI: 10.1095/Biolreprod60.2.374 |
0.308 |
|
| 1999 |
Wong PYD, Chan HC, Leung PS, Chung YW, Wong YL, Lee WM, Ng V, Dun NJ. Regulation of anion secretion by cyclo-oxygenase and prostanoids in cultured epididymal epithelia from the rat. The Journal of Physiology. 514: 809-820. PMID 9882752 DOI: 10.1111/J.1469-7793.1999.809Ad.X |
0.336 |
|
| 1999 |
Leung PS, Chan WP, Wong TP, Sernia C. Expression and localization of the renin-angiotensin system in the rat pancreas. The Journal of Endocrinology. 160: 13-9. PMID 9854172 DOI: 10.1677/Joe.0.1600013 |
0.393 |
|
| 1998 |
Leung PS, Wong TP, Wong PY, Chan HC. Localization and distribution of pituitary adenylate cyclase-activating polypeptide in the rat epididymis. Cell Biology International. 22: 193-8. PMID 9974213 DOI: 10.1006/Cbir.1998.0239 |
0.304 |
|
| 1998 |
So SC, Wu WL, Grima J, Leung PS, Chung YW, Cheng CY, Wong PY, Yan YC, Chan HC. Functional expression of sperm angiotensin II type I receptor in Xenopus oocyte: modulation of a sperm Ca2+-activated K+ channel. Biochimica Et Biophysica Acta. 1415: 261-5. PMID 9858746 DOI: 10.1016/S0005-2736(98)00201-6 |
0.32 |
|
| 1998 |
Cheng HS, Leung PY, Cheng Chew SB, Leung PS, Lam SY, Wong WS, Wang ZD, Chan HC. Concurrent and independent HCO3- and Cl- secretion in a human pancreatic duct cell line (CAPAN-1). The Journal of Membrane Biology. 164: 155-67. PMID 9662559 DOI: 10.1007/S002329900401 |
0.312 |
|
| 1998 |
Leung PS, Chan HC, Wong PYD. Immunohistochemical localization of angiotensin II in the mouse pancreas. Histochemical Journal. 30: 21-25. PMID 9539203 DOI: 10.1023/A:1003210428276 |
0.374 |
|
| 1997 |
Leung PS, Yao XQ, Chan HC, Fu LXM, Wong PYD. Differential Gene Expression Of Angiotensin Ii Receptor Subtypes In The Epididymides Of Mature And Immature Rats Life Sciences. 62: 461-468. PMID 9449237 DOI: 10.1016/S0024-3205(97)01140-5 |
0.353 |
|
| 1997 |
Zhou WL, Leung PS, Wong TP, Dun NJ, Wong PY, Chan HC. Local regulation of epididymal anion secretion by pituitary adenylate cyclase-activating polypeptide. The Journal of Endocrinology. 154: 389-95. PMID 9379115 DOI: 10.1677/Joe.0.1540389 |
0.354 |
|
| 1997 |
Leung PS, Chan HC, Fu LXM, Wong PYD. Localization of angiotensin II receptor subtypes AT1 and AT2 in the pancreas of rodents. Journal of Endocrinology. 153: 269-274. PMID 9166116 DOI: 10.1677/Joe.0.1530269 |
0.376 |
|
| 1997 |
Leung PS, Chan HC, Fu LXM, Leung PY, Chew SBC, Wong PYD. Angiotensin II receptors: Localization of type I and type II in rat epididymides of different developmental stages Journal of Membrane Biology. 157: 97-103. PMID 9141362 DOI: 10.1007/S002329900219 |
0.321 |
|
| 1997 |
Chan HC, Law SH, Leung PS, Fu LXM, Wong PYD. Angiotensin II Receptor Type I-Regulated Anion Secretion in Cystic Fibrosis Pancreatic Duct Cells The Journal of Membrane Biology. 156: 241-249. PMID 9096065 DOI: 10.1007/S002329900204 |
0.369 |
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