| Year |
Citation |
Score |
| 2020 |
Connor K, Murray DW, Jarzabek MA, Tran NL, White K, Dicker P, Sweeney KJ, O'Halloran PJ, MacCarthy B, Shiels LP, Lodi F, Lambrechts D, Sarkaria JN, Schiffelers RM, Symons M, et al. Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies. Cancers. 12. PMID 33256106 DOI: 10.3390/cancers12123531 |
0.352 |
|
| 2020 |
Ding Z, Dong Z, Yang Y, Fortin Ensign SP, Sabit H, Nakada M, Ruggieri R, Kloss JM, Symons M, Tran NL, Loftus JC. The guanine nucleotide exchange factor, LARG, and RhoC play a role in glioblastoma cell invasion and resistance. The American Journal of Pathology. PMID 32693062 DOI: 10.1016/J.Ajpath.2020.07.005 |
0.545 |
|
| 2020 |
Abrams M, Reichman N, Khatri D, Patel NV, D'Amico RS, Wong T, Fralin S, Li M, Symons M, Langer D, Filippi CG, Boockvar JA. Update on glioma biotechnology. Clinical Neurology and Neurosurgery. 195: 106075. PMID 32653731 DOI: 10.1016/J.Clineuro.2020.106075 |
0.33 |
|
| 2020 |
Maloney C, Kallis MP, Edelman M, Tzanavaris C, Lesser M, Soffer SZ, Symons M, Steinberg BM. Gefitinib inhibits invasion and metastasis of osteosarcoma via inhibition of macrophage Receptor Interacting Serine/Threonine Kinase 2. Molecular Cancer Therapeutics. PMID 32371577 DOI: 10.1158/1535-7163.Mct-19-0903 |
0.46 |
|
| 2020 |
Kallis MP, Maloney C, Blank B, Soffer SZ, Symons M, Steinberg BM. Pharmacological prevention of surgery-accelerated metastasis in an animal model of osteosarcoma. Journal of Translational Medicine. 18: 183. PMID 32354335 DOI: 10.1186/S12967-020-02348-2 |
0.353 |
|
| 2020 |
Kwiatkowska A, Symons M. Signaling Determinants of Glioma Cell Invasion. Advances in Experimental Medicine and Biology. 1202: 129-149. PMID 32034712 DOI: 10.1007/978-3-030-30651-9_7 |
0.45 |
|
| 2020 |
Kallis MP, Maloney C, Edelman M, Soffer SZ, Symons M, Steinberg BM. Abstract PR13: Surgical excision of the primary tumor in osteosarcoma model results in enhanced metastatic growth by modulating the lung immune microenvironment Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-Pr13 |
0.355 |
|
| 2019 |
Skeie B, Ruggieri R, Boockvar JA, Symons M. Colony Stimulating Factor-1 Receptor Inhibitors-A 4 for 1 Deal in the Desire to Improve Glioma Radiotherapy. Neurosurgery. 81: N27-N28. PMID 28859456 DOI: 10.1093/Neuros/Nyx389 |
0.335 |
|
| 2019 |
Mark DJ, Shen ZT, Ruggieri R, Symons MH, Sigalov AB. Abstract LB-193: Preclinical antitumor activity of a first-in-class TREM-1 inhibitory peptide GF9 as monotherapy and in combo with chemotherapy or radiation Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Lb-193 |
0.375 |
|
| 2019 |
Kallis MP, Maloney C, Symons M, Steinberg BM, Soffer SZ. Promotion of Metastasis by Surgical Excision of the Primary Tumor Reflects Changes in the Lung Immune Microenvironment Journal of the American College of Surgeons. 229: S215. DOI: 10.1016/J.Jamcollsurg.2019.08.468 |
0.311 |
|
| 2019 |
Mark DJ, Ruggieri M, Sigalov AB, Symons M. Targeting Tumor-Associated Macrophages to Radiosensitize Glioblastoma in a Mouse Model International Journal of Radiation Oncology Biology Physics. 105. DOI: 10.1016/J.Ijrobp.2019.06.1018 |
0.345 |
|
| 2018 |
Ding Z, Dhruv H, Kwiatkowska-Piwowarczyk A, Ruggieri R, Kloss J, Symons M, Pirrotte P, Eschbacher JM, Tran NL, Loftus JC. PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival. Neoplasia (New York, N.Y.). 20: 1045-1058. PMID 30219706 DOI: 10.1016/J.Neo.2018.08.008 |
0.555 |
|
| 2018 |
Maloney C, Edelman MC, Kallis MP, Soffer SZ, Symons M, Steinberg BM. Intratibial Injection Causes Direct Pulmonary Seeding of Osteosarcoma Cells and Is Not a Spontaneous Model of Metastasis: A Mouse Osteosarcoma Model. Clinical Orthopaedics and Related Research. PMID 29601385 DOI: 10.1007/S11999.0000000000000291 |
0.326 |
|
| 2018 |
Ding Z, Dong Z, Yang Y, Fortin-Ensign S, Sabit H, Nakada M, Ruggieri R, Symons M, Tran N, Loftus J. ANGI-02. A CRITICAL ROLE FOR LARG IN RhoC MEDIATED GLIOBLASTOMA CELL INVASION Neuro-Oncology. 20. DOI: 10.1093/Neuonc/Noy148.104 |
0.475 |
|
| 2018 |
Kallis MP, Maloney CW, Symons M, Steinberg BM, Soffer SZ. Surgical Removal of the Primary Tumor Accelerates Pulmonary Metastasis in a Mouse Model of Osteosarcoma Journal of the American College of Surgeons. 227: S202-S203. DOI: 10.1016/J.Jamcollsurg.2018.07.444 |
0.328 |
|
| 2018 |
Maloney CW, Kallis MP, Symons M, Steinberg BM, Soffer SZ. Selective Depletion of Pulmonary Alveolar Macrophages Inhibits Metastatic Outgrowth in a Mouse Model of Osteosarcoma Journal of the American College of Surgeons. 227: S201-S202. DOI: 10.1016/J.Jamcollsurg.2018.07.442 |
0.3 |
|
| 2017 |
Markowitz D, Ha G, Ruggieri R, Symons M. Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism. Oncotargets and Therapy. 10: 5633-5642. PMID 29200877 DOI: 10.2147/Ott.S143096 |
0.308 |
|
| 2017 |
De Witt M, Gamble A, Hanson D, Markowitz D, Powell C, Al Dimassi S, Atlas M, Boockvar J, Ruggieri R, Symons M. Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors. Molecular Medicine (Cambridge, Mass.). 23. PMID 28386621 DOI: 10.2119/Molmed.2017.00011 |
0.405 |
|
| 2017 |
Hendricks L, Aziz M, Yang WL, Nicastro J, Coppa GF, Symons M, Wang P. Milk fat globule-epidermal growth factor-factor VIII-derived peptide MSP68 is a cytoskeletal immunomodulator of neutrophils that inhibits Rac1. The Journal of Surgical Research. 208: 10-19. PMID 27993196 DOI: 10.1016/J.Jss.2016.08.098 |
0.306 |
|
| 2017 |
Maloney CW, Edelman M, Symons M, Steinberg BM, Soffer SZ. Gefitinib Blocks Macrophage-Promoted Invasion of Osteosarcoma via Inhibition of Receptor-Interacting Protein Kinase 2 (RIPK2) and Prevents Progression of Pulmonary Micrometastases Journal of the American College of Surgeons. 225: S150. DOI: 10.1016/J.Jamcollsurg.2017.07.337 |
0.389 |
|
| 2016 |
Coniglio S, Miller I, Symons M, Segall JE. Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion. Journal of Visualized Experiments : Jove. PMID 27805587 DOI: 10.3791/53990 |
0.758 |
|
| 2016 |
Mukherjee S, Baidoo J, Fried A, Atwi D, Dolai S, Boockvar J, Symons M, Ruggieri R, Raja K, Banerjee P. Curcumin Changes the Polarity of Tumor-Associated Microglia and Eliminates Glioblastoma. International Journal of Cancer. PMID 27543754 DOI: 10.1002/Ijc.30398 |
0.4 |
|
| 2016 |
Markowitz D, Powell C, Tran NL, Berens ME, Ryken TC, Vanan M, Rosen L, He M, Sun S, Symons M, Al-Abed Y, Ruggieri R. Pharmacological inhibition of the protein kinase MRK/ZAK radiosensitizes medulloblastoma. Molecular Cancer Therapeutics. PMID 27207779 DOI: 10.1158/1535-7163.Mct-15-0849 |
0.397 |
|
| 2016 |
Kelley K, Knisely J, Symons M, Ruggieri R. Radioresistance of Brain Tumors. Cancers. 8. PMID 27043632 DOI: 10.3390/Cancers8040042 |
0.363 |
|
| 2016 |
Chakraborty S, Bodhinayake I, Chiluwal A, Langer DJ, Ruggieri R, Symons M, Boockvar JA. Neuro-oncology biotech industry progress report. Journal of Neuro-Oncology. PMID 26897014 DOI: 10.1007/S11060-016-2087-Z |
0.369 |
|
| 2016 |
Ensign SP, Roos A, Mathews IT, Dhruv HD, Tuncali S, Sarkaria JN, Symons MH, Loftus JC, Berens ME, Tran NL. SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide. Molecular Cancer Research : McR. 14: 302-12. PMID 26764186 DOI: 10.1158/1541-7786.Mcr-15-0183 |
0.461 |
|
| 2016 |
Maloney CW, Symons M, Steinberg BM, Soffer SZ. Epidermal Growth Factor Receptor Inhibition Decreases Macrophage-Promoted Invasion in Osteosarcoma Journal of the American College of Surgeons. 223: S140-S141. DOI: 10.1016/J.Jamcollsurg.2016.06.298 |
0.375 |
|
| 2015 |
Hesketh AJ, Maloney C, Behr CA, Edelman MC, Glick RD, Al-Abed Y, Symons M, Soffer SZ, Steinberg BM. The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma through Inhibition of Extravasation. Plos One. 10: e0145197. PMID 26709919 DOI: 10.1371/Journal.Pone.0145197 |
0.426 |
|
| 2015 |
Behr CA, Hesketh AJ, Barlow M, Glick RD, Symons M, Steinberg BM, Soffer SZ. Celecoxib inhibits Ewing sarcoma cell migration via actin modulation. The Journal of Surgical Research. PMID 25934222 DOI: 10.1016/J.Jss.2015.03.085 |
0.471 |
|
| 2015 |
Ben-Chetrit N, Chetrit D, Russell R, Körner C, Mancini M, Abdul-Hai A, Itkin T, Carvalho S, Cohen-Dvashi H, Koestler WJ, Shukla K, Lindzen M, Kedmi M, Lauriola M, Shulman Z, ... ... Symons M, et al. Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer. Science Signaling. 8: ra7. PMID 25605973 DOI: 10.1126/Scisignal.2005537 |
0.426 |
|
| 2015 |
Murray DW, O'Halloran P, Jarzabek M, MacCarthy B, Sarkaria JN, Schiffelers RM, Symons M, Byrne AT. Abstract 5093: Pre-clinical assessment of a novel anti-invasion nanoparticle therapeutic in combination with bevacizumab for the treatment of glioblastoma Cancer Research. 75: 5093-5093. DOI: 10.1158/1538-7445.Am2015-5093 |
0.393 |
|
| 2015 |
Ruggieri R, Markowitz D, Powell C, Tran N, Vanan M, He M, Al-Abed Y, Symons M. Abstract 3338: Pharmacological inhibition of MRK/ZAK kinase for the treatment of medulloblastoma Cancer Research. 75: 3338-3338. DOI: 10.1158/1538-7445.Am2015-3338 |
0.428 |
|
| 2015 |
Li L, Xu J, Davie J, Katyal S, Symons M, Vanan MI. PTPS-29UBIQUITIN CARBOXYL TERMINAL HYDROLASE-L1 (UCH-L1) IS A TUMOR SUPPRESSOR IN ATYPICAL TERATOID RHABDOID TUMORS (ATRTs) Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov228.29 |
0.418 |
|
| 2015 |
Gamble A, Witt MD, Markowitz D, Hanson D, Powell C, Atlas M, Ruggieri R, Symons M. Atps-83Repurposing Mebendazole As A Replacement For Vincristine For The Treatment Of Brain Tumors Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov204.83 |
0.392 |
|
| 2015 |
Ruggieri R, Markowitz D, Powell C, Tran N, Vanan M, He M, Abed YA, Symons M. Mb-05Pharmacological Inhibition Of Mrk/Zak Kinase For The Treatment Of Medulloblastoma Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov061.81 |
0.416 |
|
| 2014 |
Miller IS, Didier S, Murray DW, Turner TH, Issaivanan M, Ruggieri R, Al-Abed Y, Symons M. Semapimod sensitizes glioblastoma tumors to ionizing radiation by targeting microglia. Plos One. 9: e95885. PMID 24816734 DOI: 10.1371/Journal.Pone.0095885 |
0.461 |
|
| 2014 |
Murray DW, Didier S, Chan A, Paulino V, Van Aelst L, Ruggieri R, Tran NL, Byrne AT, Symons M. Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation. British Journal of Cancer. 110: 1307-15. PMID 24518591 DOI: 10.1038/Bjc.2014.39 |
0.474 |
|
| 2014 |
Khalil BD, Hanna S, Saykali BA, El-Sitt S, Nasrallah A, Marston D, El-Sabban M, Hahn KM, Symons M, El-Sibai M. The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility. Experimental Cell Research. 321: 109-22. PMID 24333506 DOI: 10.1016/J.Yexcr.2013.11.023 |
0.507 |
|
| 2014 |
Kwiatkowska A, Paulino V, Dong Z, Loftus J, Kloss J, Ruggieri R, Tran N, Symons M. CB-11DIVERSE ROLES FOR RhoA AND RhoC IN GLIOBLASTOMA Neuro-Oncology. 16. DOI: 10.1093/Neuonc/Nou241.10 |
0.529 |
|
| 2014 |
Hesketh A, Barlow M, Steinberg B, Symons M, Soffer S. M2 Macrophages Induce Ewing’s Sarcoma Cellular Proliferation and Invasion Journal of Surgical Research. 186: 685. DOI: 10.1016/J.Jss.2013.11.968 |
0.351 |
|
| 2013 |
Fortin Ensign SP, Mathews IT, Symons MH, Berens ME, Tran NL. Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression. Frontiers in Oncology. 3: 241. PMID 24109588 DOI: 10.3389/Fonc.2013.00241 |
0.539 |
|
| 2013 |
Fortin Ensign SP, Mathews IT, Eschbacher JM, Loftus JC, Symons MH, Tran NL. The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2. The Journal of Biological Chemistry. 288: 21887-97. PMID 23775076 DOI: 10.1074/Jbc.M113.468686 |
0.532 |
|
| 2013 |
Korkina O, Dong Z, Marullo A, Warshaw G, Symons M, Ruggieri R. The MLK-related kinase (MRK) is a novel RhoC effector that mediates lysophosphatidic acid (LPA)-stimulated tumor cell invasion. The Journal of Biological Chemistry. 288: 5364-73. PMID 23319595 DOI: 10.1074/Jbc.M112.414060 |
0.516 |
|
| 2013 |
Kwiatkowska A, Symons M. Signaling determinants of glioma cell invasion. Advances in Experimental Medicine and Biology. 986: 121-41. PMID 22879067 DOI: 10.1007/978-94-007-4719-7_7 |
0.538 |
|
| 2013 |
Ben-Chetrit N, Chetrit D, Koerner C, Carvalho S, Symons M, Schmitt F, Wiemann S, Ehrlich M, Yarden Y. Abstract A84: Synaptojanin-2 and microRNA-31 control invadopodia and metastasis by regulating vesicular trafficking Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A84 |
0.497 |
|
| 2013 |
Murray DW, Didier S, Paulino VM, Chan A, Tran NL, Byrne AT, Symons MH. Abstract LB-40: Guanine nucleotide exchange factors Dock7 and Ect2 mediate HGF/c-MET-induced glioblastoma cell invasion. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-40 |
0.547 |
|
| 2013 |
Fortin SP, Mathews IT, Rollo J, Ross JTD, Symons MH, Sarkaria JN, Tran NL. Abstract 4108: SGEF is overexpressed in glioblastoma and mediates TWEAK-Fn14 induced cell survival. Cancer Research. 73: 4108-4108. DOI: 10.1158/1538-7445.Am2013-4108 |
0.483 |
|
| 2012 |
Chuang Y, Xu X, Kwiatkowska A, Tsapraillis G, Hwang H, Petritis K, Flynn D, Symons M. Regulation of synaptojanin 2 5'-phosphatase activity by Src. Cell Adhesion & Migration. 6: 518-25. PMID 23076136 DOI: 10.4161/Cam.22139 |
0.459 |
|
| 2012 |
Kwiatkowska A, Didier S, Fortin S, Chuang Y, White T, Berens ME, Rushing E, Eschbacher J, Tran NL, Chan A, Symons M. The small GTPase RhoG mediates glioblastoma cell invasion. Molecular Cancer. 11: 65. PMID 22966858 DOI: 10.1186/1476-4598-11-65 |
0.482 |
|
| 2012 |
Fortin SP, Ennis MJ, Schumacher CA, Zylstra-Diegel CR, Williams BO, Ross JT, Winkles JA, Loftus JC, Symons MH, Tran NL. Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells. Molecular Cancer Research : McR. 10: 958-68. PMID 22571869 DOI: 10.1158/1541-7786.Mcr-11-0616 |
0.53 |
|
| 2012 |
Vanan I, Dong Z, Tosti E, Warshaw G, Symons M, Ruggieri R. Role of a DNA damage checkpoint pathway in ionizing radiation-induced glioblastoma cell migration and invasion. Cellular and Molecular Neurobiology. 32: 1199-208. PMID 22552889 DOI: 10.1007/S10571-012-9846-Y |
0.497 |
|
| 2012 |
Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, Segall JE. Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Molecular Medicine (Cambridge, Mass.). 18: 519-27. PMID 22294205 DOI: 10.2119/Molmed.2011.00217 |
0.768 |
|
| 2012 |
Kwiatkowska A, Dong Z, Paulino VM, Tran NL, Ruggieri R, Symons MH. Abstract LB-516: PDZ-RhoGEF promotes glioblastoma cell invasion, proliferation and survival Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-516 |
0.43 |
|
| 2012 |
Murray DW, Didier S, Chan A, Paulino V, Tran N, Byrne A, Symons M. Abstract LB-515: Guanine nucleotide exchange factor Dock7 expression is increased in human glioblastoma and mediates tumor cell invasion. Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-515 |
0.553 |
|
| 2012 |
Miller IS, Didier S, Murray DW, Issaivanan M, Coniglio SJ, Segall JE, Al-Abed Y, Symons M. Abstract LB-503: Pharmacological inhibition of microglia leads to increased survival in a murine model of glioblastoma multiforme in conjunction with ionizing radiation Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-503 |
0.75 |
|
| 2012 |
Coniglio SJ, Eugenin E, Dobrenis K, West B, Symons M, Segall JE. Abstract 46: Microglial stimulation of glioblastoma invasion involves EGFR and CSF-1R signaling Cancer Research. 72: 46-46. DOI: 10.1158/1538-7445.Am2012-46 |
0.779 |
|
| 2012 |
Yang FH, Zhang B, Zhou DJ, Bie L, Tom MW, Drummond DC, Nicolaides T, Mueller S, Banerjee A, Park JW, Prados MD, James DC, Gupta N, Hashizume R, Strohbehn GW, ... ... Symons M, et al. LAB-EXPERIMENTAL (PRE-CLINICAL) THERAPEUTICS AND PHARMACOLOGY Neuro-Oncology. 14: vi25-vi37. DOI: 10.1093/Neuonc/Nos222 |
0.687 |
|
| 2012 |
Kijima N, Hosen N, Kagawa N, Hashimoto N, Chiba Y, Kinoshita M, Sugiyama H, Yoshimine T, Kim YZ, Kim KH, Lee EH, Hu B, Sim H, Mohan N, Agudelo-Garcia P, ... ... Symons M, et al. LAB-CELL BIOLOGY AND SIGNALING Neuro-Oncology. 14: vi7-vi20. DOI: 10.1093/Neuonc/Nos220 |
0.358 |
|
| 2011 |
Symons M. Rac1 activation comes full circle. The Embo Journal. 30: 3875-7. PMID 21975373 DOI: 10.1038/Emboj.2011.330 |
0.336 |
|
| 2011 |
Vader P, van der Meel R, Symons MH, Fens MH, Pieters E, Wilschut KJ, Storm G, Jarzabek M, Gallagher WM, Schiffelers RM, Byrne AT. Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach. Angiogenesis. 14: 457-66. PMID 21789714 DOI: 10.1007/S10456-011-9229-X |
0.418 |
|
| 2011 |
van der Meel R, Symons MH, Kudernatsch R, Kok RJ, Schiffelers RM, Storm G, Gallagher WM, Byrne AT. The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy. Drug Discovery Today. 16: 219-28. PMID 21262381 DOI: 10.1016/J.Drudis.2011.01.005 |
0.375 |
|
| 2011 |
Fortin SP, Rollo J, Paquette K, Chan A, Ross J, Symons M, Tran NL. Abstract 3846: SGEF is over-expressed in advanced glial tumors and mediates glioma cell invasion and survival Cancer Research. 71: 3846-3846. DOI: 10.1158/1538-7445.Am2011-3846 |
0.517 |
|
| 2010 |
Wu R, Abramson AL, Symons MH, Steinberg BM. Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression. International Journal of Cancer. Journal International Du Cancer. 127: 2230-7. PMID 20131316 DOI: 10.1002/Ijc.25226 |
0.417 |
|
| 2010 |
Coniglio SJ, Kedrin D, Dobrenis K, Symons M, Segall JE. Abstract 552: Microglia-stimulation of glioma cell invasion is dependent on EGFR and CSF1R signaling Cancer Research. 70: 552-552. DOI: 10.1158/1538-7445.Am10-552 |
0.786 |
|
| 2010 |
Ennis MJ, McDonough WS, Chan A, Symons MH, Winkles JA, Salhia B, Loftus JC, Tran NL. Abstract 5128: Identification of RhoGEFs within the TWEAK-R (Fn14)-Rac1 signaling pathway that mediate glioblastoma cell invasion Cancer Research. 70: 5128-5128. DOI: 10.1158/1538-7445.Am10-5128 |
0.552 |
|
| 2010 |
Lucs AV, Wu R, Symons MH, Abramson AL, Steinberg BM. Abstract 5062: Rac1 signaling is up-regulated in normal tissue adjacent to recurrent respiratory papillomas Cancer Research. 70: 5062-5062. DOI: 10.1158/1538-7445.Am10-5062 |
0.402 |
|
| 2009 |
Zavarella SM, Smith J, Yang Y, Belverud SA, Latefi A, Mittler M, Schneider SJ, Symons MH. Identification of Rho Guanine Nucleotide Exchange Factors as Novel Therapeutic Targets for Medulloblastoma Invasion: 952. Neurosurgery. 65: 417-418. PMID 28173375 DOI: 10.1227/01.Neu.0000358723.69636.69 |
0.334 |
|
| 2009 |
Zavarella S, Nakada M, Belverud S, Coniglio SJ, Chan A, Mittler MA, Schneider SJ, Symons M. Role of Rac1-regulated signaling in medulloblastoma invasion. Laboratory investigation. Journal of Neurosurgery. Pediatrics. 4: 97-104. PMID 19645540 DOI: 10.3171/2009.4.Peds08322 |
0.738 |
|
| 2009 |
Symons M, Segall JE. Rac and Rho driving tumor invasion: who's at the wheel? Genome Biology. 10: 213. PMID 19291272 DOI: 10.1186/Gb-2009-10-3-213 |
0.416 |
|
| 2008 |
Salhia B, Tran NL, Chan A, Wolf A, Nakada M, Rutka F, Ennis M, McDonough WS, Berens ME, Symons M, Rutka JT. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. The American Journal of Pathology. 173: 1828-38. PMID 19008376 DOI: 10.2353/Ajpath.2008.080043 |
0.496 |
|
| 2008 |
Symons M. Cell biology: watching the first steps of podosome formation. Current Biology : Cb. 18: R925-7. PMID 18957242 DOI: 10.1016/J.Cub.2008.08.034 |
0.389 |
|
| 2008 |
Laragione T, Brenner M, Mello A, Symons M, Gulko PS. The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts. Arthritis and Rheumatism. 58: 2296-306. PMID 18668563 DOI: 10.1002/Art.23610 |
0.308 |
|
| 2008 |
Coniglio SJ, Zavarella S, Symons MH. Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Molecular and Cellular Biology. 28: 4162-72. PMID 18411304 DOI: 10.1128/Mcb.01532-07 |
0.779 |
|
| 2008 |
El-Sibai M, Pertz O, Pang H, Yip SC, Lorenz M, Symons M, Condeelis JS, Hahn KM, Backer JM. RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Experimental Cell Research. 314: 1540-52. PMID 18316075 DOI: 10.1016/J.Yexcr.2008.01.016 |
0.497 |
|
| 2008 |
Salhia B, Hwang JH, Smith CA, Nakada M, Rutka F, Symons M, Rutka JT. Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas. Cell Motility and the Cytoskeleton. 65: 12-24. PMID 17896341 DOI: 10.1002/Cm.20240 |
0.418 |
|
| 2008 |
Schneider S, Zavarella S, Coniglio S, Belverud S, Mittler aM, Symons M. Role of Rac1-Mediated Signaling in Medulloblastoma Invasion and Growth Journal of Neurosurgery. 1. DOI: 10.3171/Ped/2008/1/4/Paper15 |
0.776 |
|
| 2007 |
Yip SC, El-Sibai M, Coniglio SJ, Mouneimne G, Eddy RJ, Drees BE, Neilsen PO, Goswami S, Symons M, Condeelis JS, Backer JM. The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. Journal of Cell Science. 120: 3138-46. PMID 17698922 DOI: 10.1242/Jcs.005298 |
0.746 |
|
| 2007 |
Chan A, Akhtar M, Brenner M, Zheng Y, Gulko PS, Symons M. The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients. Molecular Medicine. 13: 297-304. PMID 17622308 DOI: 10.2119/2007-00025.Chan |
0.425 |
|
| 2007 |
Wu R, Coniglio SJ, Chan A, Symons MH, Steinberg BM. Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas. Molecular Medicine (Cambridge, Mass.). 13: 143-50. PMID 17592548 DOI: 10.2119/2007-00005.Wu |
0.76 |
|
| 2007 |
Chuang YY, Valster A, Coniglio SJ, Backer JM, Symons M. The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration. Journal of Cell Science. 120: 1927-34. PMID 17504809 DOI: 10.1242/Jcs.03456 |
0.759 |
|
| 2007 |
Zavarella SM, Belverud S, Chan A, Steinberg B, Mittler M, Schneider SJ, Symons MH. Rac1-regulated Signaling as a Novel Therapeutic Target for Medulloblastoma Neurosurgery. 61: 210-210. DOI: 10.1227/01.Neu.0000279927.65375.77 |
0.318 |
|
| 2006 |
Tran NL, McDonough WS, Savitch BA, Fortin SP, Winkles JA, Symons M, Nakada M, Cunliffe HE, Hostetter G, Hoelzinger DB, Rennert JL, Michaelson JS, Burkly LC, Lipinski CA, Loftus JC, et al. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Research. 66: 9535-42. PMID 17018610 DOI: 10.1158/0008-5472.Can-06-0418 |
0.51 |
|
| 2006 |
Salhia B, Tran NL, Symons M, Winkles JA, Rutka JT, Berens ME. Molecular pathways triggering glioma cell invasion. Expert Review of Molecular Diagnostics. 6: 613-26. PMID 16824034 DOI: 10.1586/14737159.6.4.613 |
0.462 |
|
| 2005 |
Valster A, Tran NL, Nakada M, Berens ME, Chan AY, Symons M. Cell migration and invasion assays. Methods (San Diego, Calif.). 37: 208-15. PMID 16288884 DOI: 10.1016/J.Ymeth.2005.08.001 |
0.47 |
|
| 2005 |
Chan AY, Coniglio SJ, Chuang YY, Michaelson D, Knaus UG, Philips MR, Symons M. Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogene. 24: 7821-9. PMID 16027728 DOI: 10.1038/Sj.Onc.1208909 |
0.769 |
|
| 2005 |
Di Marzio P, Dai WW, Franchin G, Chan AY, Symons M, Sherry B. Role of Rho family GTPases in CCR1- and CCR5-induced actin reorganization in macrophages. Biochemical and Biophysical Research Communications. 331: 909-16. PMID 15882964 DOI: 10.1016/J.Bbrc.2005.04.015 |
0.351 |
|
| 2005 |
Swant JD, Rendon BE, Symons M, Mitchell RA. Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1. The Journal of Biological Chemistry. 280: 23066-72. PMID 15840582 DOI: 10.1074/jbc.M500636200 |
0.303 |
|
| 2005 |
Fan S, Gao M, Meng Q, Laterra JJ, Symons MH, Coniglio S, Pestell RG, Goldberg ID, Rosen EM. Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene. 24: 1749-66. PMID 15688034 DOI: 10.1038/Sj.Onc.1208327 |
0.405 |
|
| 2005 |
Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, Condeelis J. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. The Journal of Cell Biology. 168: 441-52. PMID 15684033 DOI: 10.1083/Jcb.200407076 |
0.751 |
|
| 2004 |
Chuang YY, Tran NL, Rusk N, Nakada M, Berens ME, Symons M. Role of synaptojanin 2 in glioma cell migration and invasion. Cancer Research. 64: 8271-5. PMID 15548694 DOI: 10.1158/0008-5472.Can-04-2097 |
0.528 |
|
| 2004 |
Cheng TL, Symons M, Jou TS. Regulation of anoikis by Cdc42 and Rac1. Experimental Cell Research. 295: 497-511. PMID 15093747 DOI: 10.1016/J.Yexcr.2004.02.002 |
0.49 |
|
| 2004 |
Karnoub AE, Symons M, Campbell SL, Der CJ. Molecular basis for Rho GTPase signaling specificity. Breast Cancer Research and Treatment. 84: 61-71. PMID 14999155 DOI: 10.1023/B:Brea.0000018427.84929.5C |
0.354 |
|
| 2004 |
Schlunck G, Damke H, Kiosses WB, Rusk N, Symons MH, Waterman-Storer CM, Schmid SL, Schwartz MA. Modulation of Rac localization and function by dynamin. Molecular Biology of the Cell. 15: 256-67. PMID 14617821 DOI: 10.1091/Mbc.E03-01-0019 |
0.372 |
|
| 2003 |
Neumeister P, Pixley FJ, Xiong Y, Xie H, Wu K, Ashton A, Cammer M, Chan A, Symons M, Stanley ER, Pestell RG. Cyclin D1 governs adhesion and motility of macrophages. Molecular Biology of the Cell. 14: 2005-15. PMID 12802071 DOI: 10.1091/Mbc.02-07-0102 |
0.403 |
|
| 2003 |
Symons M, Rusk N. Control of vesicular trafficking by Rho GTPases. Current Biology : Cb. 13: R409-18. PMID 12747855 DOI: 10.1016/S0960-9822(03)00324-5 |
0.301 |
|
| 2003 |
Rusk N, Le PU, Mariggio S, Guay G, Lurisci C, Nabi IR, Corda D, Symons M. Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis. Current Biology : Cb. 13: 659-63. PMID 12699622 DOI: 10.1016/S0960-9822(03)00241-0 |
0.328 |
|
| 2003 |
Symons M, Rusk N. ErratumControl of Vesicular Trafficking by Rho GTPases Current Biology. DOI: 10.1016/J.Cub.2003.09.029 |
0.306 |
|
| 2002 |
Banyard J, Symons M. Cell motility and invasion assays. Methods in Molecular Biology (Clifton, N.J.). 189: 129-40. PMID 12094581 DOI: 10.1385/1-59259-281-3:129 |
0.33 |
|
| 2002 |
Van Aelst L, Symons M. Role of Rho family GTPases in epithelial morphogenesis. Genes & Development. 16: 1032-54. PMID 12000787 DOI: 10.1101/Gad.978802 |
0.407 |
|
| 2001 |
Martin CB, Mahon GM, Klinger MB, Kay RJ, Symons M, Der CJ, Whitehead IP. The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. Oncogene. 20: 1953-63. PMID 11360179 DOI: 10.1038/Sj.Onc.1204281 |
0.383 |
|
| 2001 |
Ruggieri R, Chuang Y, Symons M. The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts. Molecular Medicine. 7: 293-300. DOI: 10.1007/Bf03402212 |
0.493 |
|
| 2001 |
Bouzahzah B, Albanese C, Ahmed F, Pixley F, Lisanti MP, Segall JD, Condeelis J, Joyce D, Minden A, Der CJ, Chan A, Symons M, Pestell RG. Rho Family GTPases Regulate Mammary Epithelium Cell Growth and Metastasis Through Distinguishable Pathways Molecular Medicine. 7: 816-830. DOI: 10.1007/Bf03401974 |
0.492 |
|
| 2000 |
Malecz N, McCabe PC, Spaargaren C, Qiu R, Chuang Y, Symons M. Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis. Current Biology : Cb. 10: 1383-6. PMID 11084340 DOI: 10.1016/S0960-9822(00)00778-8 |
0.428 |
|
| 2000 |
Zohn IE, Klinger M, Karp X, Kirk H, Symons M, Chrzanowska-Wodnicka M, Der CJ, Kay RJ. G2A is an oncogenic G protein-coupled receptor. Oncogene. 19: 3866-77. PMID 10951580 DOI: 10.1038/Sj.Onc.1203731 |
0.35 |
|
| 2000 |
Symons M. Adhesion signaling: PAK meets Rac on solid ground. Current Biology : Cb. 10: R535-7. PMID 10898998 DOI: 10.1016/S0960-9822(00)00588-1 |
0.381 |
|
| 2000 |
Banyard J, Anand-Apte B, Symons M, Zetter BR. Motility and invasion are differentially modulated by Rho family GTPases. Oncogene. 19: 580-91. PMID 10698528 DOI: 10.1038/Sj.Onc.1203338 |
0.507 |
|
| 1998 |
Malliri A, Symons M, Hennigan RF, Hurlstone AFL, Lamb RF, Wheeler T, Ozanne BW. The transcription factor AP-1 is required for EGF-induced activation of Rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells Journal of Cell Biology. 143: 1087-1099. PMID 9817764 DOI: 10.1083/Jcb.143.4.1087 |
0.489 |
|
| 1998 |
Westwick JK, Lee RJ, Lambert QT, Symons M, Pestell RG, Der CJ, Whitehead IP. Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun Journal of Biological Chemistry. 273: 16739-16747. PMID 9642229 DOI: 10.1074/Jbc.273.27.16739 |
0.349 |
|
| 1998 |
Kheradmand F, Werner E, Tremble P, Symons M, Werb Z. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science (New York, N.Y.). 280: 898-902. PMID 9572733 DOI: 10.1126/Science.280.5365.898 |
0.408 |
|
| 1998 |
Zohn IE, Symons M, Chrzanowska-Wodnicka M, Westwick JK, Der CJ. Mas oncogene signaling and transformation require the small GTP-binding protein Rac. Molecular and Cellular Biology. 18: 1225-35. PMID 9488437 DOI: 10.1128/Mcb.18.3.1225 |
0.371 |
|
| 1997 |
Falasca M, Carvelli A, Iurisci C, Qiu RG, Symons MH, Corda D. Fast receptor-induced formation of glycerophosphoinositol-4-phosphate, a putative novel intracellular messenger in the Ras pathway. Molecular Biology of the Cell. 8: 443-53. PMID 9188097 DOI: 10.1091/Mbc.8.3.443 |
0.306 |
|
| 1997 |
Qiu RG, Abo A, McCormick F, Symons M. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Molecular and Cellular Biology. 17: 3449-58. PMID 9154844 DOI: 10.1128/Mcb.17.6.3449 |
0.363 |
|
| 1997 |
Hess JA, Ross AH, Qiu RG, Symons M, Exton JH. Role of Rho family proteins in phospholipase D activation by growth factors Journal of Biological Chemistry. 272: 1615-1620. PMID 8999836 DOI: 10.1074/Jbc.272.3.1615 |
0.439 |
|
| 1996 |
Vexler ZS, Symons M, Barber DL. Activation of Na +-H + exchange is necessary for RhoA-induced stress fiber formation Journal of Biological Chemistry. 271: 22281-22284. PMID 8798382 DOI: 10.1074/Jbc.271.37.22281 |
0.307 |
|
| 1996 |
Hooley R, Yu CY, Symons M, Barber DL. Gα13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways Journal of Biological Chemistry. 271: 6152-6158. PMID 8626403 DOI: 10.1074/Jbc.271.11.6152 |
0.417 |
|
| 1996 |
Symons M, Derry JMJ, Karlak B, Jiang S, Lemahieu V, McCormick F, Francke U, Abo A. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization Cell. 84: 723-734. PMID 8625410 DOI: 10.1016/S0092-8674(00)81050-8 |
0.318 |
|
| 1996 |
Symons M. Rho family GTPases: the cytoskeleton and beyond Trends in Biochemical Sciences. 21: 178-181. DOI: 10.1016/S0968-0004(96)10022-0 |
0.369 |
|
| 1995 |
Marcusohn J, Isakoff SJ, Rose E, Symons M, Skolnik EY. The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes Current Biology. 5: 1296-1302. PMID 8574587 DOI: 10.1016/S0960-9822(95)00256-9 |
0.341 |
|
| 1995 |
Symons M. The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies. Current Opinion in Biotechnology. 6: 668-674. PMID 8527838 DOI: 10.1016/0958-1669(95)80110-3 |
0.349 |
|
| 1995 |
Peppelenbosch MP, Qiu RG, de Vries-Smits AM, Tertoolen LG, de Laat SW, McCormick F, Hall A, Symons MH, Bos JL. Rac mediates growth factor-induced arachidonic acid release. Cell. 81: 849-56. PMID 7781062 DOI: 10.1016/0092-8674(95)90005-5 |
0.301 |
|
| 1995 |
Siddiqi AR, Smith JL, Ross AH, Qiu RG, Symons M, Exton JH. Regulation of phospholipase D in HL60 cells: Evidence for a cytosolic phospholipase D Journal of Biological Chemistry. 270: 8466-8473. PMID 7721742 DOI: 10.1074/Jbc.270.15.8466 |
0.338 |
|
| 1995 |
Qiu RG, Chen J, Kirn D, McCormick F, Symons M. An essential role for Rac in Ras transformation. Nature. 374: 457-9. PMID 7700355 DOI: 10.1038/374457A0 |
0.349 |
|
| 1995 |
Hawkins PT, Eguinoa A, Qiu R, Stokoe D, Cooke FT, Walters R, Wennström S, Claesson-Welsh L, Evans T, Symons M, Stephens L. PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase Current Biology. 5: 393-403. PMID 7627555 DOI: 10.1016/S0960-9822(95)00080-7 |
0.416 |
|
| 1994 |
Freed E, Symons M, Macdonald SG, McCormick F, Ruggieri R. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science (New York, N.Y.). 265: 1713-6. PMID 8085158 DOI: 10.1126/Science.8085158 |
0.334 |
|
| 1992 |
Symons MH, Mitchison TJ. A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts. The Journal of Cell Biology. 118: 1235-44. PMID 1512294 DOI: 10.1083/Jcb.118.5.1235 |
0.327 |
|
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