| Year |
Citation |
Score |
| 2020 |
Staudt RP, Smithgall TE. Nef Homodimers Downregulate SERINC5 by AP-2-Mediated Endocytosis to Promote HIV-1 Infectivity. The Journal of Biological Chemistry. PMID 32873704 DOI: 10.1074/Jbc.Ra120.014668 |
0.369 |
|
| 2020 |
Staudt RP, Alvarado JJ, Emert-Sedlak LA, Shi H, Shu ST, Wales TE, Engen JR, Smithgall TE. Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes. The Journal of Biological Chemistry. PMID 32862141 DOI: 10.1074/Jbc.Rev120.012317 |
0.473 |
|
| 2020 |
Patel RK, Patel YK, Smithgall TE. Evolution Reveals a Single Mutation as Sole Source of Src-Family Kinase C-Helix-out Inhibitor Resistance. Acs Chemical Biology. PMID 32602694 DOI: 10.1021/Acschembio.0C00373 |
0.369 |
|
| 2020 |
Li WF, Aryal M, Shu ST, Smithgall TE. HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane. The Journal of Biological Chemistry. PMID 32144207 DOI: 10.1074/Jbc.Ra120.012536 |
0.554 |
|
| 2019 |
Dorman HR, Close D, Wingert BM, Camacho CJ, Johnston PA, Smithgall TE. Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck. Frontiers in Chemistry. 7: 822. PMID 31850311 DOI: 10.3389/Fchem.2019.00822 |
0.434 |
|
| 2019 |
Patel RK, Weir MC, Shen K, Snyder D, Cooper VS, Smithgall TE. Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance. Plos One. 14: e0225887. PMID 31790499 DOI: 10.1371/Journal.Pone.0225887 |
0.427 |
|
| 2019 |
Shi HE, Tice CM, Emert-Sedlak LA, Chen L, Li WF, Carlsen M, Wrobel JE, Reitz AB, Smithgall TE. Tight-binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-mediated MHC-I downregulation. Acs Infectious Diseases. PMID 31775511 DOI: 10.1021/Acsinfecdis.9B00382 |
0.448 |
|
| 2019 |
Kall SL, Whitlatch K, Smithgall TE, Lavie A. Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase. Scientific Reports. 9: 17121. PMID 31745227 DOI: 10.1038/S41598-019-53447-0 |
0.375 |
|
| 2018 |
Shen K, Moroco JA, Patel RK, Shi H, Engen JR, Dorman HR, Smithgall TE. The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation. Science Signaling. 11. PMID 30352950 DOI: 10.1126/Scisignal.Aat5916 |
0.486 |
|
| 2018 |
Weir MC, Shu ST, Patel RK, Hellwig S, Chen L, Tan L, Gray NS, Smithgall TE. Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo. Acs Chemical Biology. PMID 29763550 DOI: 10.1021/Acschembio.8B00154 |
0.428 |
|
| 2018 |
Shi J, Xiong R, Zhou T, Su P, Zhang X, Qiu X, Li H, Li S, Yu C, Wang B, Ding C, Smithgall TE, Zheng YH. HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome/lysosome system. Journal of Virology. PMID 29514909 DOI: 10.1128/JVI.00196-18 |
0.362 |
|
| 2018 |
Wu M, Alvarado JJ, Augelli-Szafran CE, Ptak RG, Smithgall TE. A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding. Plos One. 13: e0192512. PMID 29415006 DOI: 10.1371/journal.pone.0192512 |
0.381 |
|
| 2017 |
Moroco JA, Alvarado JJ, Staudt RP, Shic H, Wales TE, Smithgall TE, Engen JR. Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding. Journal of Molecular Biology. PMID 29258818 DOI: 10.1016/J.Jmb.2017.12.008 |
0.448 |
|
| 2017 |
Mujib S, Saiyed A, Fadel S, Bozorgzad A, Aidarus N, Yue FY, Benko E, Kovacs C, Emert-Sedlak LA, Smithgall TE, Ostrowski MA. Pharmacologic HIV-1 Nef blockade promotes CD8 T cell-mediated elimination of latently HIV-1-infected cells in vitro. Jci Insight. 2. PMID 28878119 DOI: 10.1172/jci.insight.93684 |
0.346 |
|
| 2017 |
Advani G, Lim YC, Catimel B, Lio DSS, Ng NLY, Chüeh AC, Tran M, Anasir MI, Verkade H, Zhu HJ, Turk BE, Smithgall TE, Ang CS, Griffin M, Cheng HC. Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine. Cell Communication and Signaling : Ccs. 15: 29. PMID 28784162 DOI: 10.1186/S12964-017-0186-X |
0.451 |
|
| 2017 |
Weir MC, Hellwig S, Tan L, Liu Y, Gray NS, Smithgall TE. Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth. Plos One. 12: e0181178. PMID 28727840 DOI: 10.1371/Journal.Pone.0181178 |
0.355 |
|
| 2017 |
Eells R, Whitlatch K, Heinrich F, Lösche M, Smithgall TE. Progress Towards a Membrane-Bound Structure of the ITK/NEF Complex Biophysical Journal. 112: 378a. DOI: 10.1016/J.Bpj.2016.11.2055 |
0.51 |
|
| 2016 |
Badger J, Grover P, Panjarian SB, Engen JR, Smithgall TE, Makowski L. The c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution. Biochemistry. PMID 27166638 DOI: 10.1021/Acs.Biochem.6B00202 |
0.456 |
|
| 2016 |
Emert-Sedlak LA, Loughran HM, Shi H, Kulp JL, Shu ST, Zhao J, Day BW, Wrobel JE, Reitz AB, Smithgall TE. Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists. Bioorganic & Medicinal Chemistry Letters. 26: 1480-4. PMID 26852364 DOI: 10.1016/J.Bmcl.2016.01.043 |
0.371 |
|
| 2016 |
Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE. Dynamics of the Tec-family Tyrosine Kinase SH3 domains. Protein Science : a Publication of the Protein Society. PMID 26808198 DOI: 10.1002/Pro.2887 |
0.313 |
|
| 2015 |
Wales TE, Hochrein JM, Morgan CR, Emert-Sedlak LA, Smithgall TE, Engen JR. Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor. Biochemistry. 54: 6382-91. PMID 26440750 DOI: 10.1021/Acs.Biochem.5B00875 |
0.532 |
|
| 2015 |
Grover P, Shi H, Baumgartner M, Camacho CJ, Smithgall TE. Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function. Plos One. 10: e0133590. PMID 26222440 DOI: 10.1371/Journal.Pone.0133590 |
0.437 |
|
| 2015 |
Moroco JA, Baumgartner MP, Rust HL, Choi HG, Hur W, Gray NS, Camacho CJ, Smithgall TE. A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region. Chemical Biology & Drug Design. 86: 144-55. PMID 25376742 DOI: 10.1111/Cbdd.12473 |
0.428 |
|
| 2014 |
Zhang X, Simerly C, Hartnett C, Schatten G, Smithgall TE. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Research. 13: 379-89. PMID 25305536 DOI: 10.1016/J.Scr.2014.09.007 |
0.407 |
|
| 2014 |
Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE. Differential sensitivity of Src-family kinases to activation by SH3 domain displacement. Plos One. 9: e105629. PMID 25144189 DOI: 10.1371/Journal.Pone.0105629 |
0.482 |
|
| 2014 |
Alvarado JJ, Tarafdar S, Yeh JI, Smithgall TE. Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment. The Journal of Biological Chemistry. 289: 28539-53. PMID 25122770 DOI: 10.1074/Jbc.M114.600031 |
0.51 |
|
| 2014 |
Tarafdar S, Poe JA, Smithgall TE. The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner. The Journal of Biological Chemistry. 289: 15718-28. PMID 24722985 DOI: 10.1074/Jbc.M114.572099 |
0.578 |
|
| 2014 |
Iyer PC, Zhao J, Emert-Sedlak LA, Moore KK, Smithgall TE, Day BW. Synthesis and structure-activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor. Bioorganic & Medicinal Chemistry Letters. 24: 1702-6. PMID 24650642 DOI: 10.1016/J.Bmcl.2014.02.045 |
0.397 |
|
| 2014 |
Poe JA, Vollmer L, Vogt A, Smithgall TE. Development and validation of a high-content bimolecular fluorescence complementation assay for small-molecule inhibitors of HIV-1 Nef dimerization Journal of Biomolecular Screening. 19: 556-565. PMID 24282155 DOI: 10.1177/1087057113513640 |
0.364 |
|
| 2014 |
Zhang X, Meyn MA, Smithgall TE. c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src. Acs Chemical Biology. 9: 139-46. PMID 23895624 DOI: 10.1021/Cb400249B |
0.335 |
|
| 2013 |
Smithgall TE, Thomas G. Small molecule inhibitors of the HIV-1 virulence factor, Nef. Drug Discovery Today. Technologies. 10: e523-9. PMID 24451644 DOI: 10.1016/J.Ddtec.2013.07.002 |
0.311 |
|
| 2013 |
Trible RP, Narute P, Emert-Sedlak LA, Alvarado JJ, Atkins K, Thomas L, Kodama T, Yanamala N, Korotchenko V, Day BW, Thomas G, Smithgall TE. Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen. Retrovirology. 10: 135. PMID 24229420 DOI: 10.1186/1742-4690-10-135 |
0.482 |
|
| 2013 |
Perrone R, Nadai M, Frasson I, Poe JA, Butovskaya E, Smithgall TE, Palumbo M, Palù G, Richter SN. A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter. Journal of Medicinal Chemistry. 56: 6521-30. PMID 23865750 DOI: 10.1021/Jm400914R |
0.315 |
|
| 2013 |
Emert-Sedlak LA, Narute P, Shu ST, Poe JA, Shi H, Yanamala N, Alvarado JJ, Lazo JS, Yeh JI, Johnston PA, Smithgall TE. Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chemistry & Biology. 20: 82-91. PMID 23352142 DOI: 10.1016/J.Chembiol.2012.11.005 |
0.412 |
|
| 2013 |
Panjarian S, Iacob RE, Chen S, Engen JR, Smithgall TE. Structure and dynamic regulation of Abl kinases. The Journal of Biological Chemistry. 288: 5443-50. PMID 23316053 DOI: 10.1074/Jbc.R112.438382 |
0.385 |
|
| 2013 |
Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE. Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. The Journal of Biological Chemistry. 288: 6116-29. PMID 23303187 DOI: 10.1074/Jbc.M112.431312 |
0.437 |
|
| 2013 |
O'Reilly LP, Zhang X, Smithgall TE. Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation. Cellular Signalling. 25: 860-6. PMID 23266470 DOI: 10.1016/J.Cellsig.2012.12.009 |
0.359 |
|
| 2012 |
Hellwig S, Miduturu CV, Kanda S, Zhang J, Filippakopoulos P, Salah E, Deng X, Choi HG, Zhou W, Hur W, Knapp S, Gray NS, Smithgall TE. Small-molecule inhibitors of the c-Fes protein-tyrosine kinase. Chemistry & Biology. 19: 529-40. PMID 22520759 DOI: 10.1016/J.Chembiol.2012.01.020 |
0.399 |
|
| 2012 |
Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE. HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck. Bmc Chemical Biology. 12: 1. PMID 22420777 DOI: 10.1186/1472-6769-12-1 |
0.584 |
|
| 2012 |
Narute PS, Smithgall TE. Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. Plos One. 7: e32561. PMID 22393415 DOI: 10.1371/journal.pone.0032561 |
0.515 |
|
| 2012 |
Moroco J, Craigo J, Gray N, Smithgall T. 225 Diversity in Individual Src-family Kinase Regulation: Opportunities for Selective Inhibitor Discovery European Journal of Cancer. 48: 68. DOI: 10.1016/S0959-8049(12)72023-3 |
0.351 |
|
| 2011 |
Lee J, Su EW, Zhu C, Hainline S, Phuah J, Moroco JA, Smithgall TE, Kuchroo VK, Kane LP. Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways. Molecular and Cellular Biology. 31: 3963-74. PMID 21807895 DOI: 10.1128/Mcb.05297-11 |
0.366 |
|
| 2011 |
Marcsisin SR, Narute PS, Emert-Sedlak LA, Kloczewiak M, Smithgall TE, Engen JR. On the solution conformation and dynamics of the HIV-1 viral infectivity factor. Journal of Molecular Biology. 410: 1008-22. PMID 21763503 DOI: 10.1016/J.Jmb.2011.04.053 |
0.374 |
|
| 2011 |
Hellwig S, Smithgall TE. Structure and regulation of the c-Fes protein-tyrosine kinase. Frontiers in Bioscience (Landmark Edition). 16: 3146-55. PMID 21622225 DOI: 10.2741/3902 |
0.335 |
|
| 2010 |
Alvarado JJ, Betts L, Moroco JA, Smithgall TE, Yeh JI. Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism. The Journal of Biological Chemistry. 285: 35455-61. PMID 20810664 DOI: 10.1074/Jbc.M110.145102 |
0.472 |
|
| 2010 |
Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, ... ... Smithgall TE, et al. Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Molecular Biology of the Cell. 21: 3279-92. PMID 20702582 DOI: 10.1091/Mbc.E10-05-0470 |
0.443 |
|
| 2010 |
Pene-Dumitrescu T, Smithgall TE. Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner. The Journal of Biological Chemistry. 285: 21446-57. PMID 20452982 DOI: 10.1074/jbc.M109.090043 |
0.407 |
|
| 2010 |
Panjarian S, Chen S, Engen J, Smithgall T. Enhanced SH3:Linker Interaction Suppresses Activating Mutations of the c-Abl Protein-Tyrosine Kinase. Blood. 116: 1208-1208. DOI: 10.1182/Blood.V116.21.1208.1208 |
0.43 |
|
| 2009 |
Meyn MA, Smithgall TE. Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. Science Signaling. 2: ra64. PMID 19825829 DOI: 10.1126/scisignal.2000311 |
0.369 |
|
| 2009 |
Emert-Sedlak L, Kodama T, Lerner EC, Dai W, Foster C, Day BW, Lazo JS, Smithgall TE. Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. Acs Chemical Biology. 4: 939-47. PMID 19807124 DOI: 10.1021/Cb900195C |
0.432 |
|
| 2009 |
Poe JA, Smithgall TE. HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication. Journal of Molecular Biology. 394: 329-42. PMID 19781555 DOI: 10.1016/J.Jmb.2009.09.047 |
0.389 |
|
| 2009 |
Choi Y, Seeliger MA, Panjarian SB, Kim H, Deng X, Sim T, Couch B, Koleske AJ, Smithgall TE, Gray NS. N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor. The Journal of Biological Chemistry. 284: 29005-14. PMID 19679652 DOI: 10.1074/Jbc.M109.026633 |
0.404 |
|
| 2009 |
Molina G, Vogt A, Bakan A, Dai W, Queiroz de Oliveira P, Znosko W, Smithgall TE, Bahar I, Lazo JS, Day BW, Tsang M. Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nature Chemical Biology. 5: 680-7. PMID 19578332 DOI: 10.1038/Nchembio.190 |
0.322 |
|
| 2009 |
Shaffer JM, Hellwig S, Smithgall TE. Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells. Biochemistry. 48: 4780-8. PMID 19382747 DOI: 10.1021/Bi900238F |
0.323 |
|
| 2009 |
Iacob RE, Pene-Dumitrescu T, Zhang J, Gray NS, Smithgall TE, Engen JR. Conformational disturbance in Abl kinase upon mutation and deregulation. Proceedings of the National Academy of Sciences of the United States of America. 106: 1386-91. PMID 19164531 DOI: 10.1073/Pnas.0811912106 |
0.384 |
|
| 2008 |
Pene-Dumitrescu T, Peterson LF, Donato NJ, Smithgall TE. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. Oncogene. 27: 7055-69. PMID 18794796 DOI: 10.1038/Onc.2008.330 |
0.522 |
|
| 2008 |
Chen S, O'Reilly LP, Smithgall TE, Engen JR. Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. Journal of Molecular Biology. 383: 414-23. PMID 18775435 DOI: 10.1016/J.Jmb.2008.08.040 |
0.441 |
|
| 2008 |
Engen JR, Wales TE, Hochrein JM, Meyn MA, Banu Ozkan S, Bahar I, Smithgall TE. Structure and dynamic regulation of Src-family kinases. Cellular and Molecular Life Sciences : Cmls. 65: 3058-73. PMID 18563293 DOI: 10.1007/S00018-008-8122-2 |
0.406 |
|
| 2008 |
Meyn MA, Smithgall TE. Small molecule inhibitors of Lck: the search for specificity within a kinase family. Mini Reviews in Medicinal Chemistry. 8: 628-37. PMID 18537718 DOI: 10.2174/138955708784534454 |
0.417 |
|
| 2008 |
Chen S, Dumitrescu TP, Smithgall TE, Engen JR. Abl N-terminal cap stabilization of SH3 domain dynamics. Biochemistry. 47: 5795-803. PMID 18452309 DOI: 10.1021/Bi800446B |
0.345 |
|
| 2007 |
Trible RP, Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR, Smithgall TE. Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor. Journal of Molecular Biology. 374: 121-9. PMID 17920628 DOI: 10.1016/J.Jmb.2007.09.009 |
0.512 |
|
| 2007 |
Chen S, Brier S, Smithgall TE, Engen JR. The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding. Protein Science : a Publication of the Protein Society. 16: 572-81. PMID 17327393 DOI: 10.1110/Ps.062631007 |
0.419 |
|
| 2007 |
Mitchell JL, Trible RP, Emert-Sedlak LA, Weis DD, Lerner EC, Applen JJ, Sefton BM, Smithgall TE, Engen JR. Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein. Journal of Molecular Biology. 366: 1282-93. PMID 17207813 DOI: 10.1016/J.Jmb.2006.12.026 |
0.378 |
|
| 2007 |
Pecquet C, Nyga R, Penard-Lacronique V, Smithgall TE, Murakami H, Régnier A, Lassoued K, Gouilleux F. The Src tyrosine kinase Hck is required for Tel-Abl- but not for Tel-Jak2-induced cell transformation. Oncogene. 26: 1577-85. PMID 16953222 DOI: 10.1038/Sj.Onc.1209949 |
0.497 |
|
| 2006 |
Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC. C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases. The Journal of Biological Chemistry. 281: 32988-99. PMID 16959780 DOI: 10.1074/Jbc.M602951200 |
0.469 |
|
| 2006 |
Meyn MA, Wilson MB, Abdi FA, Fahey N, Schiavone AP, Wu J, Hochrein JM, Engen JR, Smithgall TE. Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. The Journal of Biological Chemistry. 281: 30907-16. PMID 16912036 DOI: 10.1074/Jbc.M605902200 |
0.482 |
|
| 2006 |
Kanda S, Miyata Y, Kanetake H, Smithgall TE. Fibroblast growth factor-2 induces the activation of Src through Fes, which regulates focal adhesion disassembly. Experimental Cell Research. 312: 3015-22. PMID 16884713 DOI: 10.1016/J.Yexcr.2006.06.032 |
0.353 |
|
| 2006 |
Trible RP, Emert-Sedlak L, Smithgall TE. HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction. The Journal of Biological Chemistry. 281: 27029-38. PMID 16849330 DOI: 10.1074/Jbc.M601128200 |
0.578 |
|
| 2006 |
Hochrein JM, Wales TE, Lerner EC, Schiavone AP, Smithgall TE, Engen JR. Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry. Biochemistry. 45: 7733-9. PMID 16784224 DOI: 10.1021/Bi060438X |
0.336 |
|
| 2006 |
Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB, Grandis JR. Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 103: 6901-6. PMID 16641105 DOI: 10.1073/Pnas.0509719103 |
0.375 |
|
| 2005 |
Lerner EC, Trible RP, Schiavone AP, Hochrein JM, Engen JR, Smithgall TE. Activation of the Src family kinase Hck without SH3-linker release. The Journal of Biological Chemistry. 280: 40832-7. PMID 16210316 DOI: 10.1074/Jbc.M508782200 |
0.509 |
|
| 2005 |
Meyn MA, Schreiner SJ, Dumitrescu TP, Nau GJ, Smithgall TE. SRC family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology. 68: 1320-30. PMID 15985613 DOI: 10.1124/Mol.104.010231 |
0.465 |
|
| 2004 |
Ye H, Choi HJ, Poe J, Smithgall TE. Oligomerization is required for HIV-1 Nef-induced activation of the Src family protein-tyrosine kinase, Hck. Biochemistry. 43: 15775-84. PMID 15595833 DOI: 10.1021/Bi048712F |
0.607 |
|
| 2004 |
Choi HJ, Smithgall TE. Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase. Journal of Molecular Biology. 343: 1255-68. PMID 15491611 DOI: 10.1016/J.Jmb.2004.09.015 |
0.58 |
|
| 2004 |
Choi HJ, Smithgall TE. HIV-1 Nef promotes survival of TF-1 macrophages by inducing Bcl-XL expression in an extracellular signal-regulated kinase-dependent manner. The Journal of Biological Chemistry. 279: 51688-96. PMID 15459189 DOI: 10.1074/Jbc.M410068200 |
0.597 |
|
| 2004 |
Zhang Q, Thomas SM, Xi S, Smithgall TE, Siegfried JM, Kamens J, Gooding WE, Grandis JR. SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Cancer Research. 64: 6166-73. PMID 15342401 DOI: 10.1158/0008-5472.Can-04-0504 |
0.404 |
|
| 2004 |
Laurent CE, Smithgall TE. The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner. Experimental Cell Research. 299: 188-98. PMID 15302586 DOI: 10.1016/J.Yexcr.2004.05.010 |
0.315 |
|
| 2004 |
Cheng HY, Li P, David M, Smithgall TE, Feng L, Lieberman MW. Arsenic inhibition of the JAK-STAT pathway. Oncogene. 23: 3603-12. PMID 15116095 DOI: 10.1038/Sj.Onc.1207466 |
0.469 |
|
| 2004 |
Trible RP, Smithgall TE. HIV-1 Nef Alleles Show Differential Activation of Hematopoietic Cell Kinase in a Yeast Model System. Blood. 104: 3107-3107. DOI: 10.1182/Blood.V104.11.3107.3107 |
0.583 |
|
| 2003 |
Shangary S, Lerner EC, Zhan Q, Corey SJ, Smithgall TE, Baskaran R. Lyn regulates the cell death response to ultraviolet radiation through c-Jun N terminal kinase-dependent Fas ligand activation. Experimental Cell Research. 289: 67-76. PMID 12941605 DOI: 10.1016/S0014-4827(03)00234-9 |
0.332 |
|
| 2003 |
Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, Kamens J, Grandis JR. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. The Journal of Biological Chemistry. 278: 31574-83. PMID 12771142 DOI: 10.1074/Jbc.M303499200 |
0.451 |
|
| 2003 |
Takashima Y, Delfino FJ, Engen JR, Superti-Furga G, Smithgall TE. Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae. Biochemistry. 42: 3567-74. PMID 12653561 DOI: 10.1021/Bi0272499 |
0.42 |
|
| 2002 |
Wilson MB, Schreiner SJ, Choi HJ, Kamens J, Smithgall TE. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 21: 8075-88. PMID 12444544 DOI: 10.1038/Sj.Onc.1206008 |
0.577 |
|
| 2002 |
Klejman A, Schreiner SJ, Nieborowska-Skorska M, Slupianek A, Wilson M, Smithgall TE, Skorski T. The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. The Embo Journal. 21: 5766-74. PMID 12411494 DOI: 10.1093/Emboj/Cdf562 |
0.526 |
|
| 2002 |
Schreiner SJ, Schiavone AP, Smithgall TE. Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. The Journal of Biological Chemistry. 277: 45680-7. PMID 12244095 DOI: 10.1074/jbc.M204255200 |
0.509 |
|
| 2002 |
Lerner EC, Smithgall TE. SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo. Nature Structural Biology. 9: 365-9. PMID 11976726 DOI: 10.1038/Nsb782 |
0.335 |
|
| 2002 |
Leong PL, Xi S, Drenning SD, Dyer KF, Wentzel AL, Lerner EC, Smithgall TE, Grandis JR. Differential function of STAT5 isoforms in head and neck cancer growth control. Oncogene. 21: 2846-53. PMID 11973644 DOI: 10.1038/Sj.Onc.1205385 |
0.316 |
|
| 2001 |
Gmeiner WH, Xu I, Horita DA, Smithgall TE, Engen JR, Smith DL, Byrd RA. Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP. Cell Biochemistry and Biophysics. 35: 115-26. PMID 11892787 DOI: 10.1385/Cbb:35:2:115 |
0.342 |
|
| 2001 |
Xie S, Wang Y, Liu J, Sun T, Wilson MB, Smithgall TE, Arlinghaus RB. Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation. Oncogene. 20: 6188-95. PMID 11593427 DOI: 10.1038/Sj.Onc.1204834 |
0.468 |
|
| 2001 |
Cheng HY, Schiavone AP, Smithgall TE. A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells. Molecular and Cellular Biology. 21: 6170-80. PMID 11509660 DOI: 10.1128/Mcb.21.18.6170-6180.2001 |
0.393 |
|
| 2001 |
Briggs SD, Scholtz B, Jacque JM, Swingler S, Stevenson M, Smithgall TE. HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway. The Journal of Biological Chemistry. 276: 25605-11. PMID 11328823 DOI: 10.1074/Jbc.M103244200 |
0.519 |
|
| 2000 |
Rogers JA, Cheng HY, Smithgall TE. Src homology 2 domain substitution modulates the kinase and transforming activities of the Fes protein-tyrosine kinase. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 11: 581-92. PMID 11095247 |
0.382 |
|
| 2000 |
Smithgall TE, Briggs SD, Schreiner S, Lerner EC, Cheng H, Wilson MB. Control of myeloid differentiation and survival by Stats. Oncogene. 19: 2612-8. PMID 10851060 DOI: 10.1038/sj.onc.1203477 |
0.305 |
|
| 2000 |
Lionberger JM, Wilson MB, Smithgall TE. Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck. The Journal of Biological Chemistry. 275: 18581-5. PMID 10849448 DOI: 10.1074/jbc.C000126200 |
0.542 |
|
| 2000 |
Zhang Y, Turkson J, Carter-Su C, Smithgall T, Levitzki A, Kraker A, Krolewski JJ, Medveczky P, Jove R. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. The Journal of Biological Chemistry. 275: 24935-44. PMID 10823829 DOI: 10.1074/Jbc.M002383200 |
0.52 |
|
| 2000 |
Glover RT, Angiolieri M, Kelly S, Monaghan DT, Wang JY, Smithgall TE, Buller AL. Interaction of the N-methyl-D-aspartic acid receptor NR2D subunit with the c-Abl tyrosine kinase. The Journal of Biological Chemistry. 275: 12725-9. PMID 10777567 DOI: 10.1074/Jbc.275.17.12725 |
0.376 |
|
| 2000 |
Kanda S, Lerner EC, Tsuda S, Shono T, Kanetake H, Smithgall TE. The nonreceptor protein-tyrosine kinase c-Fes is involved in fibroblast growth factor-2-induced chemotaxis of murine brain capillary endothelial cells. The Journal of Biological Chemistry. 275: 10105-11. PMID 10744691 DOI: 10.1074/Jbc.275.14.10105 |
0.331 |
|
| 2000 |
Lionberger JM, Smithgall TE. The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl. Cancer Research. 60: 1097-103. PMID 10706130 |
0.332 |
|
| 2000 |
Briggs SD, Lerner EC, Smithgall TE. Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo. Biochemistry. 39: 489-95. PMID 10642173 DOI: 10.1021/Bi992504J |
0.581 |
|
| 1999 |
Cheng H, Rogers JA, Dunham NA, Smithgall TE. Regulation of c-Fes tyrosine kinase and biological activities by N-terminal coiled-coil oligomerization domains. Molecular and Cellular Biology. 19: 8335-43. PMID 10567558 DOI: 10.1128/Mcb.19.12.8335 |
0.355 |
|
| 1999 |
Briggs SD, Smithgall TE. SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts. The Journal of Biological Chemistry. 274: 26579-83. PMID 10473622 DOI: 10.1074/jbc.274.37.26579 |
0.5 |
|
| 1999 |
Peters KL, Smithgall TE. Tyrosine phosphorylation enhances the SH2 domain-binding activity of Bcr and inhibits Bcr interaction with 14-3-3 proteins Cellular Signalling. 11: 507-514. PMID 10405761 DOI: 10.1016/S0898-6568(99)00021-2 |
0.478 |
|
| 1998 |
Smithgall TE, Rogers JA, Peters KL, Li J, Briggs SD, Lionberger JM, Cheng H, Shibata A, Scholtz B, Schreiner S, Dunham N. The c-Fes family of protein-tyrosine kinases Critical Reviews in Oncogenesis. 9: 43-62. PMID 9754447 DOI: 10.1615/Critrevoncog.V9.I1.40 |
0.332 |
|
| 1998 |
Li J, Smithgall TE. Fibroblast transformation by Fps/Fes tyrosine kinases requires Ras, Rac, and Cdc42 and induces extracellular signal-regulated and c-Jun N-terminal kinase activation. The Journal of Biological Chemistry. 273: 13828-34. PMID 9593727 DOI: 10.1074/jbc.273.22.13828 |
0.43 |
|
| 1998 |
Nelson KL, Rogers JA, Bowman TL, Jove R, Smithgall TE. Activation of STAT3 by the c-Fes protein-tyrosine kinase Journal of Biological Chemistry. 273: 7072-7077. PMID 9507017 DOI: 10.1074/jbc.273.12.7072 |
0.449 |
|
| 1997 |
Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry. Biochemistry. 36: 14384-91. PMID 9398156 DOI: 10.1021/Bi971635M |
0.338 |
|
| 1997 |
Briggs SD, Sharkey M, Stevenson M, Smithgall TE. SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1. The Journal of Biological Chemistry. 272: 17899-902. PMID 9218412 DOI: 10.1074/jbc.272.29.17899 |
0.613 |
|
| 1997 |
Li J, Smithgall TE. Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues. The Journal of Biological Chemistry. 271: 32930-6. PMID 8955135 DOI: 10.1074/jbc.271.51.32930 |
0.427 |
|
| 1996 |
Rogers JA, Read RD, Li J, Peters KL, Smithgall TE. Autophosphorylation of the Fes tyrosine kinase. Evidence for an intermolecular mechanism involving two kinase domain tyrosine residues Journal of Biological Chemistry. 271: 17519-17525. PMID 8663427 DOI: 10.1074/jbc.271.29.17519 |
0.352 |
|
| 1996 |
Smithgall TE. SH2 and SH3 domains: potential targets for anti-cancer drug design. Journal of Pharmacological and Toxicological Methods. 34: 125-32. PMID 8573762 DOI: 10.1016/1056-8719(95)00082-7 |
0.437 |
|
| 1996 |
Bukrinskaya AG, Ghorpade A, Heinzinger NK, Smithgall TE, Lewis RE, Stevenson M. Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. Proceedings of the National Academy of Sciences of the United States of America. 93: 367-71. PMID 8552640 DOI: 10.1073/Pnas.93.1.367 |
0.357 |
|
| 1995 |
Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE. The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck. The Journal of Biological Chemistry. 270: 14718-24. PMID 7782336 DOI: 10.1074/jbc.270.24.14718 |
0.424 |
|
| 1995 |
Maru Y, Peters KL, Afar DEH, Shibuya M, Witte ON, Smithgall TE. Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS Molecular and Cellular Biology. 15: 835-842. PMID 7529874 DOI: 10.1128/MCB.15.2.835 |
0.447 |
|
| 1993 |
Hjermstad SJ, Briggs SD, Smithgall TE. Phosphorylation of the ras GTPase-activating protein (GAP) by the p93c-fes protein-tyrosine kinase in vitro and formation of GAP-fes complexes via an SH2 domain-dependent mechanism. Biochemistry. 32: 10519-25. PMID 7691175 DOI: 10.1021/Bi00090A031 |
0.304 |
|
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