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Joshua D. Rabinowitz - Publications

Chemistry and Integrative Genomics Princeton University, Princeton, NJ 
cellular metabolism

238 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Shen Y, Dinh HV, Cruz ER, Chen Z, Bartman CR, Xiao T, Call CM, Ryseck RP, Pratas J, Weilandt D, Baron H, Subramanian A, Fatma Z, Wu ZY, Dwaraknath S, ... ... Rabinowitz JD, et al. Mitochondrial ATP generation is more proteome efficient than glycolysis. Nature Chemical Biology. PMID 38448734 DOI: 10.1038/s41589-024-01571-y  0.536
2024 Cherkaoui S, Yang L, McBride M, Turn CS, Lu W, Eigenmann C, Allen GE, Panasenko OO, Zhang L, Vu A, Liu K, Li Y, Gandhi OH, Surrey L, Wierer M, ... ... Rabinowitz JD, et al. Reprogramming neuroblastoma by diet-enhanced polyamine depletion. Biorxiv : the Preprint Server For Biology. PMID 38260457 DOI: 10.1101/2024.01.07.573662  0.517
2024 McBride MJ, Hunter CJ, Zhang Z, TeSlaa T, Xu X, Ducker GS, Rabinowitz JD. Glycine homeostasis requires reverse SHMT flux. Cell Metabolism. 36: 103-115.e4. PMID 38171330 DOI: 10.1016/j.cmet.2023.12.001  0.705
2023 Kutschka I, Bertero E, Wasmus C, Xiao K, Yang L, Chen X, Oshima Y, Fischer M, Erk M, Arslan B, Alhasan L, Grosser D, Ermer KJ, Nickel A, Kohlhaas M, ... ... Rabinowitz J, et al. Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome. Basic Research in Cardiology. 118: 47. PMID 37930434 DOI: 10.1007/s00395-023-01017-x  0.532
2023 Bartman CR, Faubert B, Rabinowitz JD, DeBerardinis RJ. Metabolic pathway analysis using stable isotopes in patients with cancer. Nature Reviews. Cancer. 23: 863-878. PMID 37907620 DOI: 10.1038/s41568-023-00632-z  0.304
2023 Leitner BP, Lee WD, Zhu W, Zhang X, Gaspar RC, Li Z, Rabinowitz JD, Perry RJ. Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis. Plos One. 18: e0286525. PMID 37410734 DOI: 10.1371/journal.pone.0286525  0.308
2023 Bartman CR, Weilandt DR, Shen Y, Lee WD, Han Y, TeSlaa T, Jankowski CSR, Samarah L, Park NR, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, ... ... Rabinowitz JD, et al. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature. PMID 36725930 DOI: 10.1038/s41586-022-05661-6  0.514
2023 Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, ... ... Rabinowitz JD, et al. Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy. Molecular Cancer Therapeutics. OF1. PMID 36602953 DOI: 10.1158/1535-7163.MCT-22-0766  0.689
2022 Chellappa K, McReynolds MR, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat YR, Lingala SR, Shima RT, Descamps HC, Cox T, Ji L, Jankowski C, Chu Q, ... ... Rabinowitz JD, et al. NAD precursors cycle between host tissues and the gut microbiome. Cell Metabolism. 34: 1947-1959.e5. PMID 36476934 DOI: 10.1016/j.cmet.2022.11.004  0.73
2022 Zhao H, Teng D, Yang L, Xu X, Chen J, Jiang T, Feng AY, Zhang Y, Frederick DT, Gu L, Cai L, Asara JM, Pasca di Magliano M, Boland GM, Flaherty KT, ... ... Rabinowitz JD, et al. Myeloid-derived itaconate suppresses cytotoxic CD8 T cells and promotes tumour growth. Nature Metabolism. PMID 36376563 DOI: 10.1038/s42255-022-00676-9  0.453
2022 Jang C, Hui S, Zeng X, Cowan AJ, Wang L, Chen L, Morscher RJ, Reyes J, Frezza C, Hwang HY, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, ... ... Rabinowitz JD, et al. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metabolism. 34: 1410. PMID 36070684 DOI: 10.1016/j.cmet.2022.08.006  0.722
2022 Zeng X, Xing X, Gupta M, Keber FC, Lopez JG, Lee YJ, Roichman A, Wang L, Neinast MD, Donia MS, Wühr M, Jang C, Rabinowitz JD. Gut bacterial nutrient preferences quantified in vivo. Cell. 185: 3441-3456.e19. PMID 36055202 DOI: 10.1016/j.cell.2022.07.020  0.73
2022 Yang L, TeSlaa T, Ng S, Nofal M, Wang L, Lan T, Zeng X, Cowan A, McBride M, Lu W, Davidson S, Liang G, Oh TG, Downes M, Evans R, ... ... Rabinowitz JD, et al. Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. Med (New York, N.Y.). 3: 119-136. PMID 35425930 DOI: 10.1016/j.medj.2021.12.008  0.769
2022 Wang L, Xing X, Zeng X, Jackson SR, TeSlaa T, Al-Dalahmah O, Samarah LZ, Goodwin K, Yang L, McReynolds MR, Li X, Wolff JJ, Rabinowitz JD, Davidson SM. Spatially resolved isotope tracing reveals tissue metabolic activity. Nature Methods. 19: 223-230. PMID 35132243 DOI: 10.1038/s41592-021-01378-y  0.792
2022 Li X, Hui S, Mirek ET, Jonsson WO, Anthony TG, Lee WD, Zeng X, Jang C, Rabinowitz JD. Circulating metabolite homeostasis achieved through mass action. Nature Metabolism. PMID 35058631 DOI: 10.1038/s42255-021-00517-1  0.761
2021 Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz GJ, Clasquin MF, Rabinowitz JD. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nature Metabolism. PMID 34845393 DOI: 10.1038/s42255-021-00487-4  0.782
2021 Ghergurovich JM, Xu X, Wang JZ, Yang L, Ryseck RP, Wang L, Rabinowitz JD. Methionine synthase supports tumour tetrahydrofolate pools. Nature Metabolism. 3: 1512-1520. PMID 34799699 DOI: 10.1038/s42255-021-00465-w  0.516
2021 Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella AD, Shen Y, Cowan A, McReynolds MR, Kennedy BJ, Lato AM, Campagna SR, Singh M, ... Rabinowitz JD, et al. Metabolite discovery through global annotation of untargeted metabolomics data. Nature Methods. PMID 34711973 DOI: 10.1038/s41592-021-01303-3  0.727
2021 Nofal M, Wang T, Yang L, Jankowski CSR, Hsin-Jung Li S, Han S, Parsons L, Frese AN, Gitai Z, Anthony TG, Wühr M, Sabatini DM, Rabinowitz JD. GCN2 adapts protein synthesis to scavenging-dependent growth. Cell Systems. PMID 34706266 DOI: 10.1016/j.cels.2021.09.014  0.473
2021 Parkhitko AA, Wang L, Filine E, Jouandin P, Leshchiner D, Binari R, Asara JM, Rabinowitz JD, Perrimon N. A genetic model of methionine restriction extends health- and lifespan. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34588310 DOI: 10.1073/pnas.2110387118  0.303
2021 Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, ... ... Rabinowitz JD, et al. Metabolic decisions in development and disease-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 34414571 DOI: 10.1111/nyas.14678  0.337
2021 Phan T, Nguyen VH, Buettner R, Morales C, Yang L, Wong P, Tsai W, Salazar MD, Gil Z, Diamond DJ, Rabinowitz JD, Rosen S, Melstrom LG. Inhibition of pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. International Journal of Biological Sciences. 17: 2240-2251. PMID 34239352 DOI: 10.7150/ijbs.60473  0.459
2021 Phan T, Nguyen VH, Buettner R, Morales C, Yang L, Wong P, Tsai W, Salazar MD, Gil Z, Diamond DJ, Rabinowitz JD, Rosen S, Melstrom LG. Inhibition of pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. International Journal of Biological Sciences. 17: 2240-2251. PMID 34239352 DOI: 10.7150/ijbs.60473  0.459
2020 Green R, Sonal, Wang L, Hart SFM, Lu W, Skelding D, Burton JC, Mi H, Capel A, Chen HA, Lin A, Subramaniam AR, Rabinowitz JD, Shou W. Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. Plos Biology. 18: e3000757. PMID 32833957 DOI: 10.1371/Journal.Pbio.3000757  0.377
2020 Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD. Quantitative Fluxomics of Circulating Metabolites. Cell Metabolism. PMID 32791100 DOI: 10.1016/J.Cmet.2020.07.013  0.811
2020 Ghassemi S, Martinez-Becerra FJ, Master AM, Richman SA, Heo D, Leferovich J, Tu Y, García-Cañaveras JC, Ayari A, Lu Y, Wang A, Rabinowitz JD, Milone MC, June CH, O'Connor RS. Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design. Molecular Therapy. Methods & Clinical Development. 18: 595-606. PMID 32775494 DOI: 10.1016/J.Omtm.2020.07.008  0.319
2020 Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz JD, Lazar MA. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science (New York, N.Y.). PMID 32732282 DOI: 10.1126/Science.Aba8984  0.346
2020 Jang C, Wada S, Yang S, Gosis B, Zeng X, Zhang Z, Shen Y, Lee G, Arany Z, Rabinowitz JD. The small intestine shields the liver from fructose-induced steatosis. Nature Metabolism. 2: 586-593. PMID 32694791 DOI: 10.1038/s42255-020-0222-9  0.737
2020 Ghergurovich JM, Esposito M, Chen Z, Wang JZ, Bhatt V, Lan T, White E, Kang Y, Guo JY, Rabinowitz JD. Glucose-6-phosphate dehydrogenase is not essential for K-Ras-driven tumor growth or metastasis. Cancer Research. PMID 32661137 DOI: 10.1158/0008-5472.Can-19-2486  0.302
2020 Lu W, Xing X, Wang L, Chen L, Zhang S, McReynolds MR, Rabinowitz JD. Improved annotation of untargeted metabolomics data through buffer modifications that shift adduct mass and intensity. Analytical Chemistry. PMID 32614575 DOI: 10.1021/Acs.Analchem.0C00985  0.323
2020 Gibney PA, Chen A, Schieler A, Chen JC, Xu Y, Hendrickson DG, McIsaac RS, Rabinowitz JD, Botstein D. A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1. Plos One. 15: e0233779. PMID 32470059 DOI: 10.1371/Journal.Pone.0233779  0.396
2020 Ghergurovich JM, García-Cañaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, ... Rabinowitz JD, et al. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nature Chemical Biology. PMID 32393898 DOI: 10.1038/S41589-020-0533-X  0.379
2020 García-Cañaveras JC, Lancho O, Ducker GS, Ghergurovich JM, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz JD. SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. PMID 32382081 DOI: 10.1038/S41375-020-0845-6  0.708
2020 Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller KD, Schug ZT, Snyder NW, Gade TP, Titchenell PM, ... Rabinowitz JD, et al. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature. 579: 586-591. PMID 32214246 DOI: 10.1038/S41586-020-2101-7  0.768
2020 Yang L, Garcia Canaveras JC, Chen Z, Wang L, Liang L, Jang C, Mayr JA, Zhang Z, Ghergurovich JM, Zhan L, Joshi S, Hu Z, McReynolds MR, Su X, White E, ... ... Rabinowitz JD, et al. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metabolism. PMID 32187526 DOI: 10.1016/J.Cmet.2020.02.017  0.574
2020 Li AM, Ducker GS, Li Y, Seoane JA, Xiao Y, Melemenidis S, Zhou Y, Liu L, Vanharanta S, Graves EE, Rankin EB, Curtis C, Massague J, Rabinowitz JD, Thompson CB, et al. Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Molecular Cancer Research : McR. PMID 31941752 DOI: 10.1158/1541-7786.Mcr-19-0606  0.716
2020 DeBerardinis R, Rabinowitz JD. Decision letter: Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma Elife. DOI: 10.7554/Elife.56782.Sa1  0.334
2020 Ghergurovich JM, O’Shaughnessy J, Levin MK, Killian A, Hendricks W, Espina V, Rabinowitz JD. Abstract P3-02-06: Tracing glucose catabolism in human triple negative breast cancer tumors Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P3-02-06  0.386
2020 Li AM, Ducker GS, Li Y, Seoane JA, Xiao Y, Melemenidis S, Zhou Y, Liu L, Vanharanta S, Graves EE, Rankin EB, Curtis C, Massague J, Rabinowitz JD, Thompson CB, et al. Abstract 5713: Reprogramming of serine metabolism during breast cancer progression Cancer Research. 80: 5713-5713. DOI: 10.1158/1538-7445.Am2020-5713  0.725
2020 Ghassemi S, Martinez-Becerra F, Master A, Richman S, Heo D, Leferovich J, Tu Y, Garcia-Canaveras J, Ayari A, Lu Y, Wang A, Rabinowitz J, Milone M, O'Connor R. Novel media formulations to enhance Chimeric Antigen Receptor (CAR) T-cell potency and anti-tumor cell function for adoptive immunotherapy Cytotherapy. 22: S133. DOI: 10.1016/J.Jcyt.2020.03.260  0.302
2019 Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, Rabinowitz JD. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nature Metabolism. 1: 404-415. PMID 32694724 DOI: 10.1038/s42255-019-0043-x  0.343
2019 Gokhale S, Lu W, Zhu S, Liu Y, Hart RP, Rabinowitz JD, Xie P. Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). PMID 31826940 DOI: 10.4049/Jimmunol.1900658  0.365
2019 Dinh HV, Suthers PF, Chan SHJ, Shen Y, Xiao T, Deewan A, Jagtap SS, Zhao H, Rao CV, Rabinowitz JD, Maranas CD. A comprehensive genome-scale model for IFO0880 accounting for functional genomics and phenotypic data. Metabolic Engineering Communications. 9: e00101. PMID 31720216 DOI: 10.1016/J.Mec.2019.E00101  0.368
2019 Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Cell Stem Cell. PMID 31564549 DOI: 10.1016/J.Stem.2019.08.017  0.389
2019 Park JO, Tanner LB, Wei MH, Khana DB, Jacobson TB, Zhang Z, Rubin SA, Li SH, Higgins MB, Stevenson DM, Amador-Noguez D, Rabinowitz JD. Near-equilibrium glycolysis supports metabolic homeostasis and energy yield. Nature Chemical Biology. PMID 31548693 DOI: 10.1038/S41589-019-0364-9  0.39
2019 Ron-Harel N, Ghergurovich JM, Notarangelo G, LaFleur MW, Tsubosaka Y, Sharpe AH, Rabinowitz JD, Haigis MC. T Cell Activation Depends on Extracellular Alanine. Cell Reports. 28: 3011-3021.e4. PMID 31533027 DOI: 10.1016/J.Celrep.2019.08.034  0.363
2019 Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ, Rabinowitz J, Craft J, Flavell RA. Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature. PMID 31447485 DOI: 10.1038/S41586-019-1490-Y  0.333
2019 Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, ... ... Rabinowitz JD, et al. Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy. Molecular Cancer Therapeutics. PMID 31289137 DOI: 10.1158/1535-7163.Mct-19-0037  0.741
2019 Jang C, Hui S, Zeng X, Cowan AJ, Wang L, Chen L, Morscher RJ, Reyes J, Frezza C, Hwang HY, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, ... ... Rabinowitz JD, et al. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metabolism. PMID 31257152 DOI: 10.1016/J.Cmet.2019.06.002  0.757
2019 Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ, Rabinowitz J, Craft J, Flavell RA. Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature. PMID 31217581 DOI: 10.1038/S41586-019-1311-3  0.351
2019 Schober AF, Mathis AD, Ingle C, Park JO, Chen L, Rabinowitz JD, Junier I, Rivoire O, Reynolds KA. A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism. Cell Reports. 27: 3359-3370.e7. PMID 31189117 DOI: 10.1016/J.Celrep.2019.05.030  0.406
2019 García-Cañaveras JC, Chen L, Rabinowitz JD. The Tumor Metabolic Microenvironment: Lessons from Lactate. Cancer Research. PMID 31171526 DOI: 10.1158/0008-5472.Can-18-3726  0.324
2019 Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, et al. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metabolism. PMID 31155495 DOI: 10.1016/J.Cmet.2019.05.005  0.336
2019 Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A. The metabolites NADP and NADPH are the targets of the circadian protein Nocturnin (Curled). Nature Communications. 10: 2367. PMID 31147539 DOI: 10.1038/S41467-019-10125-Z  0.423
2019 Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, Rabinowitz JD. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nature Metabolism. 1: 404-415. PMID 31058257  0.342
2019 Bradley PH, Gibney PA, Botstein D, Troyanskaya OG, Rabinowitz JD. Minor Isozymes Tailor Yeast Metabolism to Carbon Availability. Msystems. 4. PMID 30834327 DOI: 10.1128/mSystems.00170-18  0.803
2019 Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS. Serine Metabolism Supports Macrophage IL-1β Production. Cell Metabolism. PMID 30773464 DOI: 10.1016/J.Cmet.2019.01.014  0.696
2019 Dekhne A, Shah K, Ducker GS, Nayeen MJ, Katinas JM, Wong J, Doshi A, Bao X, Kalpage H, Liu J, Kim S, Wallace-Povirk A, Ning C, O'Connor C, Hou Z, ... ... Rabinowitz JD, et al. Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2992  0.719
2018 Wang L, Xing X, Chen L, Yang L, Su X, Rabitz HA, Lu W, Rabinowitz JD. Peak annotation and verification engine (PAVE) for untargeted LC-MS metabolomics. Analytical Chemistry. PMID 30586294 DOI: 10.1021/Acs.Analchem.8B03132  0.54
2018 Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 115: 13347-13352. PMID 30530686 DOI: 10.1073/Pnas.1804149115  0.369
2018 Minhas PS, Liu L, Moon PK, Joshi AU, Dove C, Mhatre S, Contrepois K, Wang Q, Lee BA, Coronado M, Bernstein D, Snyder MP, Migaud M, Majeti R, Mochly-Rosen D, ... Rabinowitz JD, et al. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nature Immunology. PMID 30478397 DOI: 10.1038/S41590-018-0255-3  0.317
2018 Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg MW, Mehnert JM, Guo JY, Lattime E, ... Rabinowitz JD, et al. Autophagy maintains tumour growth through circulating arginine. Nature. PMID 30429607 DOI: 10.1038/S41586-018-0697-7  0.393
2018 Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. PMID 30057115 DOI: 10.1016/J.Cell.2018.06.031  0.377
2018 Li SH, Li Z, Park JO, King CG, Rabinowitz JD, Wingreen NS, Gitai Z. Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions. Nature Microbiology. PMID 30038306 DOI: 10.1038/S41564-018-0199-2  0.344
2018 Rodan LH, Qi W, Ducker GS, Demirbas D, Laine R, Yang E, Walker MA, Eichler F, Rabinowitz JD, Anselm I, Berry GT. 5,10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination. Molecular Genetics and Metabolism. PMID 30031689 DOI: 10.1016/J.Ymgme.2018.06.006  0.728
2018 Tanner LB, Goglia AG, Wei MH, Sehgal T, Parsons LR, Park JO, White E, Toettcher JE, Rabinowitz JD. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Systems. PMID 29960885 DOI: 10.1016/J.Cels.2018.06.003  0.358
2018 Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife. 7. PMID 29893687 DOI: 10.7554/Elife.33246  0.315
2018 Jang C, Chen L, Rabinowitz JD. Metabolomics and Isotope Tracing. Cell. 173: 822-837. PMID 29727671 DOI: 10.1016/J.Cell.2018.03.055  0.384
2018 Liu L, Su X, Quinn WJ, Hui S, Krukenberg K, Frederick DW, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison TJ, Baur JA, Rabinowitz JD. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metabolism. PMID 29685734 DOI: 10.1016/J.Cmet.2018.03.018  0.429
2018 Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nature Medicine. PMID 29578539 DOI: 10.1038/Nm.4514  0.345
2018 Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. The Journal of Clinical Investigation. PMID 29533924 DOI: 10.1172/Jci94427  0.372
2018 Gibney PA, Schieler A, Chen JC, Bacha-Hummel JM, Botstein M, Volpe M, Silverman SJ, Xu Y, Bennett BD, Rabinowitz JD, Botstein D. Common and Divergent Features of Galactose-1-phosphate and Fructose-1-phosphate Toxicity in Yeast. Molecular Biology of the Cell. PMID 29444955 DOI: 10.1091/Mbc.E17-11-0666  0.646
2018 McKee SE, Zhang S, Chen L, Rabinowitz JD, Reyes TM. Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain. Journal of Neurochemistry. PMID 29423909 DOI: 10.1111/Jnc.14319  0.322
2018 Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metabolism. 27: 351-361.e3. PMID 29414685 DOI: 10.1016/J.Cmet.2017.12.016  0.362
2018 Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD. Mitochondrial translation requires folate-dependent tRNA methylation. Nature. PMID 29364879 DOI: 10.1038/Nature25460  0.714
2018 Pavlova NN, Hui S, Ghergurovich JM, Fan J, Intlekofer AM, White RM, Rabinowitz JD, Thompson CB, Zhang J. As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Cell Metabolism. PMID 29337136 DOI: 10.1016/J.Cmet.2017.12.006  0.355
2018 Dekhne AS, Ducker GS, Frühauf J, Shah K, Nayeen MJ, Wallace-Povirk A, O'Connor C, Hou Z, Polin L, Gangjee A, Rabinowitz JD, Matherly LH. Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine antifolates Cancer Research. 78: 3980-3980. DOI: 10.1158/1538-7445.Am2018-3980  0.73
2017 Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, ... ... Rabinowitz JD, et al. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. PMID 29153836 DOI: 10.1016/J.Cell.2017.10.037  0.352
2017 Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 114: 11404-11409. PMID 29073064 DOI: 10.1073/Pnas.1706617114  0.729
2017 Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Zhan, Yanxiang Guo J, White E, Rabinowitz JD. Glucose feeds the TCA cycle via circulating lactate. Nature. PMID 29045397 DOI: 10.1038/Nature24057  0.376
2017 Kim HI, Raffler J, Lu W, Lee JJ, Abbey D, Saleheen D, Rabinowitz JD, Bennett MJ, Hand NJ, Brown C, Rader DJ. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. American Journal of Human Genetics. PMID 28942964 DOI: 10.1016/J.Ajhg.2017.08.008  0.317
2017 Liu L, Rowe GC, Yang S, Li J, Damilano F, Chan MC, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann BK, Rabinowitz J, Das S, Rosenzweig A, et al. PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy. Circulation Research. PMID 28928113 DOI: 10.1161/Circresaha.117.311456  0.323
2017 Nofal M, Zhang K, Han S, Rabinowitz JD. mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein. Molecular Cell. PMID 28918901 DOI: 10.1016/J.Molcel.2017.08.011  0.306
2017 Zhang Z, Chen L, Liu L, Su X, Rabinowitz JD. Chemical basis for deuterium labeling of fat and NADPH. Journal of the American Chemical Society. PMID 28911221 DOI: 10.1021/Jacs.7B08012  0.362
2017 Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, ... ... Rabinowitz J, et al. A unified approach to targeting the lysosome's degradative and growth signaling roles. Cancer Discovery. PMID 28899863 DOI: 10.1158/2159-8290.Cd-17-0741  0.324
2017 Zhang Y, Kurupati R, Liu L, Zhou XY, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis GC, Schuchter LM, Xu W, Amaravadi R, Xiao M, Sadek N, ... ... Rabinowitz JD, et al. Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 32: 377-391.e9. PMID 28898698 DOI: 10.1016/J.Ccell.2017.08.004  0.329
2017 Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Nature Chemical Biology. PMID 28805803 DOI: 10.1038/Nchembio.2453  0.374
2017 Chen L, Ducker GS, Lu W, Teng X, Rabinowitz JD. An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate. Analytical and Bioanalytical Chemistry. PMID 28799108 DOI: 10.1007/S00216-017-0514-4  0.701
2017 Lu W, Su X, Klein MS, Lewis IA, Fiehn O, Rabinowitz JD. Metabolite Measurement: Pitfalls to Avoid and Practices to Follow. Annual Review of Biochemistry. 86: 277-304. PMID 28654323 DOI: 10.1146/Annurev-Biochem-061516-044952  0.349
2017 Rajeshkumar NV, Yabuuchi S, Pai S, De Oliveira E, Kamphorst JJ, Rabinowitz JD, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang CV. Treatment of pancreatic cancer patient-derived xenograft panel with metabolic inhibitors reveals efficacy of phenformin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28611197 DOI: 10.1158/1078-0432.Ccr-17-1115  0.313
2017 Gong Y, Cao R, Ding G, Hong S, Zhou W, Lu W, Damle M, Fang B, Wang CC, Qian J, Lie N, Lanzillotta C, Rabinowitz JD, Sun Z. Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Molecular and Cellular Endocrinology. PMID 28554803 DOI: 10.1016/J.Mce.2017.05.024  0.316
2017 Choi J, Rajagopal A, Xu YF, Rabinowitz JD, O'Shea EK. A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae. Plos One. 12: e0176085. PMID 28520786 DOI: 10.1371/Journal.Pone.0176085  0.333
2017 Lu W, Wang L, Chen L, Hui S, Rabinowitz JD. Extraction and quantitation of NAD(P)(H). Antioxidants & Redox Signaling. PMID 28497978 DOI: 10.1089/Ars.2017.7014  0.328
2017 Su X, Lu W, Rabinowitz JD. Metabolite Spectral Accuracy on Orbitraps. Analytical Chemistry. PMID 28471646 DOI: 10.1021/Acs.Analchem.7B00396  0.306
2016 Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, ... ... Rabinowitz JD, et al. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nature Medicine. PMID 28024083 DOI: 10.1038/Nm.4256  0.336
2016 Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metabolism. PMID 27866836 DOI: 10.1016/J.Cmet.2016.10.012  0.323
2016 Hackett SR, Zanotelli VR, Xu W, Goya J, Park JO, Perlman DH, Gibney PA, Botstein D, Storey JD, Rabinowitz JD. Systems-level analysis of mechanisms regulating yeast metabolic flux. Science (New York, N.Y.). 354. PMID 27789812 DOI: 10.1126/Science.Aaf2786  0.428
2016 Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metabolism. 24: 640-641. PMID 27732838 DOI: 10.1016/J.Cmet.2016.09.011  0.702
2016 Ducker GS, Rabinowitz JD. One-Carbon Metabolism in Health and Disease. Cell Metabolism. PMID 27641100 DOI: 10.1016/J.Cmet.2016.08.009  0.75
2016 Moloughney JG, Kim PK, Vega-Cotto NM, Wu CC, Zhang S, Adlam M, Lynch T, Chou PC, Rabinowitz JD, Werlen G, Jacinto E. mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Molecular Cell. PMID 27570073 DOI: 10.1016/J.Molcel.2016.07.015  0.438
2016 Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes & Development. PMID 27516533 DOI: 10.1101/Gad.283416.116  0.373
2016 Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metabolism. 24: 104-17. PMID 27411012 DOI: 10.1016/J.Cmet.2016.06.007  0.392
2016 Teng X, Emmett MJ, Lazar MA, Goldberg E, Rabinowitz JD. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. Acs Chemical Biology. PMID 27333189 DOI: 10.1021/Acschembio.6B00290  0.323
2016 Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metabolism. PMID 27211901 DOI: 10.1016/J.Cmet.2016.04.016  0.724
2016 Park JO, Rubin SA, Xu YF, Amador-Noguez D, Fan J, Shlomi T, Rabinowitz JD. Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nature Chemical Biology. PMID 27159581 DOI: 10.1038/Nchembio.2077  0.38
2016 Bren A, Park JO, Towbin BD, Dekel E, Rabinowitz JD, Alon U. Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP. Scientific Reports. 6: 24834. PMID 27109914 DOI: 10.1038/Srep24834  0.337
2016 Liu L, Shah S, Fan J, Park JO, Wellen KE, Rabinowitz JD. Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nature Chemical Biology. PMID 26999781 DOI: 10.1038/Nchembio.2047  0.43
2016 Zong WX, Rabinowitz JD, White E. Mitochondria and Cancer. Molecular Cell. 61: 667-76. PMID 26942671 DOI: 10.1016/J.Molcel.2016.02.011  0.336
2016 Ducker GS, Esposito MB, Kang Y, Rabinowitz JD. Abstract A14: Role of mitochondrial folate metabolism in cancer cell growth and proliferation Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-A14  0.757
2016 Suri V, Mainolfi N, Friedman A, Moyer MP, Ducker G, Rabinowitz JD, Manfredi M. Abstract 232: Pharmacological and genetic dissection of one carbon pathway provides novel insights into generation, transformation and utilization of one carbon units Cancer Research. 76: 232-232. DOI: 10.1158/1538-7445.Am2016-232  0.406
2016 Jacinto E, Moloughney J, Kim PK, Vega-Cotto NM, Wu C, Lynch T, Zhang S, Adlam M, Guntaka S, Chou P, Rabinowitz JD, Werlen G. Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels Cancer Research. 76: 21-21. DOI: 10.1158/1538-7445.Am2016-21  0.452
2016 Liu L, Chen L, Ducker G, Park J, Shah S, Wellen KE, Rabinowitz JD. Abstract 1013: Quantification of NADPH balance in cancer Cancer Research. 76: 1013-1013. DOI: 10.1158/1538-7445.Am2016-1013  0.385
2015 Su X, Wellen KE, Rabinowitz JD. Metabolic control of methylation and acetylation. Current Opinion in Chemical Biology. 30: 52-60. PMID 26629854 DOI: 10.1016/J.Cbpa.2015.10.030  0.385
2015 Bott AJ, Peng IC, Fan Y, Faubert B, Zhao L, Li J, Neidler S, Sun Y, Jaber N, Krokowski D, Lu W, Pan JA, Powers S, Rabinowitz J, Hatzoglou M, et al. Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation. Cell Metabolism. PMID 26603296 DOI: 10.1016/J.Cmet.2015.09.025  0.34
2015 Mok WW, Park JO, Rabinowitz JD, Brynildsen MP. RNA Futile Cycling in Model Persisters Derived from MazF Accumulation. Mbio. 6. PMID 26578677 DOI: 10.1128/Mbio.01588-15  0.399
2015 Rajeshkumar NV, Dutta P, Yabuuchi S, de Wilde RF, Matrinez GV, Le A, Kamphorst JJ, Rabinowitz JD, Jain SK, Hidalgo M, Dang CV, Gillies RJ, Maitra A. Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function. Cancer Research. PMID 26113084 DOI: 10.1158/0008-5472.Can-15-0108  0.358
2015 Gibney PA, Schieler A, Chen JC, Rabinowitz JD, Botstein D. Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter. Proceedings of the National Academy of Sciences of the United States of America. 112: 6116-21. PMID 25918382 DOI: 10.1073/Pnas.1506289112  0.396
2015 Purdy JG, Shenk T, Rabinowitz JD. Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Reports. 10: 1375-85. PMID 25732827 DOI: 10.1016/J.Celrep.2015.02.003  0.346
2015 Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, ... ... Rabinowitz JD, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology. 34: 189-201. PMID 25731751 DOI: 10.1016/J.Copbio.2015.02.003  0.368
2015 Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, Thompson CB, Rabinowitz JD. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Research. 75: 544-53. PMID 25644265 DOI: 10.1158/0008-5472.Can-14-2211  0.359
2015 Ducker GS, Rabinowitz JD. ZMP: a master regulator of one-carbon metabolism. Molecular Cell. 57: 203-4. PMID 25616065 DOI: 10.1016/J.Molcel.2015.01.012  0.718
2015 Xu YF, Lu W, Rabinowitz JD. Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomics. Analytical Chemistry. 87: 2273-81. PMID 25591916 DOI: 10.1021/Ac504118Y  0.338
2015 Aristilde L, Lewis IA, Park JO, Rabinowitz JD. Hierarchy in pentose sugar metabolism in Clostridium acetobutylicum. Applied and Environmental Microbiology. 81: 1452-62. PMID 25527534 DOI: 10.1128/Aem.03199-14  0.457
2015 Ducker GS, Chen L, Teng X, Rabinowitz JD. Abstract 4709: Compartmental flexibility in mammalian folate metabolism Cancer Research. 75: 4709-4709. DOI: 10.1158/1538-7445.Am2015-4709  0.738
2015 Jacinto E, Moloughney J, Lynch T, Wu C, Ibironke O, Navia A, Chou P, Zhang S, Rabinowitz J, Werlen G. Abstract 1150: mTORC2 enhances flux through the hexosamine biosynthetic pathway by regulation of GFAT1 expression Cancer Research. 75: 1150-1150. DOI: 10.1158/1538-7445.Am2015-1150  0.438
2014 Kamphorst JJ, Chung MK, Fan J, Rabinowitz JD. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer & Metabolism. 2: 23. PMID 25671109 DOI: 10.1186/2049-3002-2-23  0.387
2014 Hwang J, Purdy JG, Wu K, Rabinowitz JD, Shenk T. Estrogen-related receptor α is required for efficient human cytomegalovirus replication. Proceedings of the National Academy of Sciences of the United States of America. 111: E5706-15. PMID 25512541 DOI: 10.1073/Pnas.1422361112  0.317
2014 Castellana M, Wilson MZ, Xu Y, Joshi P, Cristea IM, Rabinowitz JD, Gitai Z, Wingreen NS. Enzyme clustering accelerates processing of intermediates through metabolic channeling. Nature Biotechnology. 32: 1011-8. PMID 25262299 DOI: 10.1038/Nbt.3018  0.382
2014 Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, Olin-Sandoval V, Grüning N, Krüger A, Tauqeer Alam M, Keller MA, Breitenbach M, Brindle KM, Rabinowitz JD, Ralser M. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biological Reviews of the Cambridge Philosophical Society. PMID 25243985 DOI: 10.1111/Brv.12140  0.452
2014 Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Molecular Cell. 56: 205-18. PMID 25242145 DOI: 10.1016/J.Molcel.2014.08.018  0.347
2014 Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, Thompson CB. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discovery. 4: 1406-17. PMID 25186948 DOI: 10.1158/2159-8290.Cd-14-0250  0.354
2014 Mathew R, Khor S, Hackett SR, Rabinowitz JD, Perlman DH, White E. Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunity. Molecular Cell. 55: 916-30. PMID 25175026 DOI: 10.1016/J.Molcel.2014.07.019  0.363
2014 Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discovery. 4: 914-27. PMID 24875857 DOI: 10.1158/2159-8290.Cd-14-0363  0.315
2014 Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD. Quantitative flux analysis reveals folate-dependent NADPH production. Nature. 510: 298-302. PMID 24805240 DOI: 10.1038/Nature13236  0.435
2014 Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L. Genetic basis of metabolome variation in yeast. Plos Genetics. 10: e1004142. PMID 24603560 DOI: 10.1371/Journal.Pgen.1004142  0.453
2014 Shlomi T, Fan J, Tang B, Kruger WD, Rabinowitz JD. Quantitation of cellular metabolic fluxes of methionine. Analytical Chemistry. 86: 1583-91. PMID 24397525 DOI: 10.1021/Ac4032093  0.464
2014 Fan J, Teng X, Liu L, Looper R, Rabinowitz J. Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate and promotes histone methylation Cancer & Metabolism. 2: P75. DOI: 10.1186/2049-3002-2-S1-P75  0.305
2014 Park J, Rubin S, Xu Y, Amador-Noguez D, Fan J, Rabinowitz J. Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P54  0.327
2014 Lu W, Zhang S, Teng X, Melamud E, Lazar MA, White E, Rabinowitz JD. LC-MS and GC-MS based metabolomics platform for cancer research Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P41  0.346
2014 Liu L, Shah S, Fan J, Wellen K, Rabinowitz J. Quantification of NADPH balance during adipogenesis Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-P40  0.362
2014 Altman BJ, Hsieh A, Gouw AM, Stine ZE, Venkataraman A, Bellovin DI, Diskin SJ, Lu W, Zhang S, Felsher DW, Maris JM, Lazar MA, Rabinowitz JD, Hogenesch JB, Dang CV. Abstract 2953: Rev-erbα modulates Myc-driven cancer cell growth and altered metabolism Cancer Research. 74: 2953-2953. DOI: 10.1158/1538-7445.Am2014-2953  0.384
2014 Wu C, Lynch T, Moloughney J, Navia A, Ibironke O, Chou P, Vega-Cotto NM, Zhang S, Rabinowitz J, Werlen G, Jacinto E. Abstract 2441: mTOR complex 2 modulates glycosylation of CD147 via the hexosamine biosynthetic pathway Cancer Research. 74: 2441-2441. DOI: 10.1158/1538-7445.Am2014-2441  0.371
2013 Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM. Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. Cell Reports. 5: 1725-36. PMID 24360963 DOI: 10.1016/J.Celrep.2013.11.040  0.581
2013 Fan J, Kamphorst JJ, Mathew R, Chung MK, White E, Shlomi T, Rabinowitz JD. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Molecular Systems Biology. 9: 712. PMID 24301801 DOI: 10.1038/Msb.2013.65  0.403
2013 Grady SL, Purdy JG, Rabinowitz JD, Shenk T. Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection. Proceedings of the National Academy of Sciences of the United States of America. 110: E5006-15. PMID 24297925 DOI: 10.1073/Pnas.1321305110  0.385
2013 Tepper N, Noor E, Amador-Noguez D, Haraldsdóttir HS, Milo R, Rabinowitz J, Liebermeister W, Shlomi T. Steady-State Metabolite Concentrations Reflect a Balance between Maximizing Enzyme Efficiency and Minimizing Total Metabolite Load Plos One. 8. PMID 24086517 DOI: 10.1371/Journal.Pone.0075370  0.383
2013 Fan J, Kamphorst JJ, Rabinowitz JD, Shlomi T. Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux. The Journal of Biological Chemistry. 288: 31363-9. PMID 24030823 DOI: 10.1074/Jbc.M113.502740  0.415
2013 Rabinowitz JD, Silhavy TJ. Systems biology: metabolite turns master regulator. Nature. 500: 283-4. PMID 23925111 DOI: 10.1038/Nature12544  0.305
2013 Reaves ML, Young BD, Hosios AM, Xu YF, Rabinowitz JD. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature. 500: 237-41. PMID 23903661 DOI: 10.1038/Nature12445  0.819
2013 Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, Snyder E, Santanam U, Dipaola RS, Jacks T, Rabinowitz JD, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes & Development. 27: 1447-61. PMID 23824538 DOI: 10.1101/Gad.219642.113  0.314
2013 Koyuncu E, Purdy JG, Rabinowitz JD, Shenk T. Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny. Plos Pathogens. 9: e1003333. PMID 23696731 DOI: 10.1371/Journal.Ppat.1003333  0.369
2013 Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proceedings of the National Academy of Sciences of the United States of America. 110: 8882-7. PMID 23671091 DOI: 10.1073/Pnas.1307237110  0.367
2013 Xu YF, Létisse F, Absalan F, Lu W, Kuznetsova E, Brown G, Caudy AA, Yakunin AF, Broach JR, Rabinowitz JD. Nucleotide degradation and ribose salvage in yeast. Molecular Systems Biology. 9: 665. PMID 23670538 DOI: 10.1038/Msb.2013.21  0.391
2013 Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 497: 633-7. PMID 23665962 DOI: 10.1038/Nature12138  0.332
2013 Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature. 497: 652. PMID 23615611 DOI: 10.1038/Nature12164  0.311
2013 Shlomi T, Rabinowitz JD. Metabolism: Cancer mistunes methylation. Nature Chemical Biology. 9: 293-4. PMID 23594782 DOI: 10.1038/Nchembio.1234  0.341
2012 Xu YF, Zhao X, Glass DS, Absalan F, Perlman DH, Broach JR, Rabinowitz JD. Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylation. Molecular Cell. 48: 52-62. PMID 22902555 DOI: 10.1016/J.Molcel.2012.07.013  0.319
2012 Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfield RJ. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science (New York, N.Y.). 337: 470-3. PMID 22773140 DOI: 10.1126/Science.1219861  0.769
2012 Grady SL, Hwang J, Vastag L, Rabinowitz JD, Shenk T. Herpes simplex virus 1 infection activates poly(ADP-ribose) polymerase and triggers the degradation of poly(ADP-ribose) glycohydrolase. Journal of Virology. 86: 8259-68. PMID 22623791 DOI: 10.1128/Jvi.00495-12  0.79
2012 Rabinowitz JD, Vastag L. Teaching the design principles of metabolism. Nature Chemical Biology. 8: 497-501. PMID 22596190 DOI: 10.1038/Nchembio.969  0.791
2012 Xu YF, Amador-Noguez D, Reaves ML, Feng XJ, Rabinowitz JD. Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase. Nature Chemical Biology. 8: 562-8. PMID 22522319 DOI: 10.1038/Nchembio.941  0.794
2012 Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB. Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 109: 6904-9. PMID 22509023 DOI: 10.1073/Pnas.1204176109  0.361
2012 Peterson CN, Levchenko I, Rabinowitz JD, Baker TA, Silhavy TJ. RpoS proteolysis is controlled directly by ATP levels in Escherichia coli. Genes & Development. 26: 548-53. PMID 22426532 DOI: 10.1101/Gad.183517.111  0.415
2012 Clasquin MF, Melamud E, Rabinowitz JD. LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. Current Protocols in Bioinformatics / Editoral Board, Andreas D. Baxevanis ... [Et Al.]. Unit14.11. PMID 22389014 DOI: 10.1002/0471250953.Bi1411S37  0.74
2012 Terry LJ, Vastag L, Rabinowitz JD, Shenk T. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proceedings of the National Academy of Sciences of the United States of America. 109: 3071-6. PMID 22315427 DOI: 10.1073/Pnas.1200494109  0.802
2012 Kamphorst JJ, Cross JR, Fan J, Lu W, White E, Thompson CB, Rabinowitz JD. Ras-driven cancer cells can scavenge exogenous lipids to support their proliferation Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-P25  0.355
2012 Rajeshkumar NV, Dutta P, Kamphorst J, Le A, Yabuuchi S, Wilde RFd, Campbell NR, Oliveira ED, Jesus-Acosta AD, Rabinowitz J, Laheru D, Jain SK, Hidalgo M, Thompson CB, Hoff DDV, et al. Abstract LB-61: Targeting cancer cell metabolism in pancreatic cancer: p53, a key regulator of glycolysis and a major factor deciding the outcome of targeting the Warburg effect Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-61  0.363
2011 Rabinowitz JD, Purdy JG, Vastag L, Shenk T, Koyuncu E. Metabolomics in drug target discovery. Cold Spring Harbor Symposia On Quantitative Biology. 76: 235-46. PMID 22114327 DOI: 10.1101/Sqb.2011.76.010694  0.803
2011 Kamphorst JJ, Fan J, Lu W, White E, Rabinowitz JD. Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Analytical Chemistry. 83: 9114-22. PMID 22004349 DOI: 10.1021/Ac202220B  0.367
2011 Doucette CD, Schwab DJ, Wingreen NS, Rabinowitz JD. α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nature Chemical Biology. 7: 894-901. PMID 22002719 DOI: 10.1038/Nchembio.685  0.689
2011 Amador-Noguez D, Brasg IA, Feng XJ, Roquet N, Rabinowitz JD. Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum. Applied and Environmental Microbiology. 77: 7984-97. PMID 21948824 DOI: 10.1128/Aem.05374-11  0.423
2011 Strelko CL, Lu W, Dufort FJ, Seyfried TN, Chiles TC, Rabinowitz JD, Roberts MF. Itaconic acid is a mammalian metabolite induced during macrophage activation. Journal of the American Chemical Society. 133: 16386-9. PMID 21919507 DOI: 10.1021/Ja2070889  0.36
2011 Vastag L, Koyuncu E, Grady SL, Shenk TE, Rabinowitz JD. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. Plos Pathogens. 7: e1002124. PMID 21779165 DOI: 10.1371/Journal.Ppat.1002124  0.81
2011 Petti AA, Crutchfield CA, Rabinowitz JD, Botstein D. Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America. 108: E1089-98. PMID 21734149 DOI: 10.1073/Pnas.1101494108  0.731
2011 Clasquin MF, Melamud E, Singer A, Gooding JR, Xu X, Dong A, Cui H, Campagna SR, Savchenko A, Yakunin AF, Rabinowitz JD, Caudy AA. Riboneogenesis in yeast. Cell. 145: 969-80. PMID 21663798 DOI: 10.1016/J.Cell.2011.05.022  0.783
2011 Reaves ML, Rabinowitz JD. Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvG. Journal of Bacteriology. 193: 4576-81. PMID 21531803 DOI: 10.1128/Jb.00325-11  0.781
2011 Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW. Remodeling of the metabolome during early frog development. Plos One. 6: e16881. PMID 21347444 DOI: 10.1371/Journal.Pone.0016881  0.802
2011 Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes & Development. 25: 460-70. PMID 21317241 DOI: 10.1101/Gad.2016311  0.356
2011 Klosinska MM, Crutchfield CA, Bradley PH, Rabinowitz JD, Broach JR. Yeast cells can access distinct quiescent states. Genes & Development. 25: 336-49. PMID 21289062 DOI: 10.1101/Gad.2011311  0.798
2011 Hart Y, Madar D, Yuan J, Bren A, Mayo AE, Rabinowitz JD, Alon U. Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Molecular Cell. 41: 117-27. PMID 21211727 DOI: 10.1016/J.Molcel.2010.12.023  0.344
2011 Reaves ML, Rabinowitz JD. Metabolomics in systems microbiology. Current Opinion in Biotechnology. 22: 17-25. PMID 21050741 DOI: 10.1016/J.Copbio.2010.10.001  0.815
2011 Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Erratum: Branched tricarboxylic acid metabolism in Plasmodium falciparum Nature. 469: 432-432. DOI: 10.1038/Nature09712  0.385
2010 Rabinowitz JD, White E. Autophagy and metabolism. Science (New York, N.Y.). 330: 1344-8. PMID 21127245 DOI: 10.1126/Science.1193497  0.397
2010 Wellen KE, Lu C, Mancuso A, Lemons JM, Ryczko M, Dennis JW, Rabinowitz JD, Coller HA, Thompson CB. The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes & Development. 24: 2784-99. PMID 21106670 DOI: 10.1101/Gad.1985910  0.39
2010 Melamud E, Vastag L, Rabinowitz JD. Metabolomic analysis and visualization engine for LC-MS data. Analytical Chemistry. 82: 9818-26. PMID 21049934 DOI: 10.1021/Ac1021166  0.784
2010 Lemons JM, Feng XJ, Bennett BD, Legesse-Miller A, Johnson EL, Raitman I, Pollina EA, Rabitz HA, Rabinowitz JD, Coller HA. Quiescent fibroblasts exhibit high metabolic activity. Plos Biology. 8: e1000514. PMID 21049082 DOI: 10.1371/Journal.Pbio.1000514  0.711
2010 Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, Tsukamoto T, Rojas CJ, Slusher BS, Rabinowitz JD, Dang CV, Riggins GJ. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Research. 70: 8981-7. PMID 21045145 DOI: 10.1158/0008-5472.Can-10-1666  0.642
2010 Merritt JH, Ha DG, Cowles KN, Lu W, Morales DK, Rabinowitz J, Gitai Z, O'Toole GA. Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases. Mbio. 1. PMID 20978535 DOI: 10.1128/Mbio.00183-10  0.326
2010 Crutchfield CA, Lu W, Melamud E, Rabinowitz JD. Mass spectrometry-based metabolomics of yeast. Methods in Enzymology. 470: 393-426. PMID 20946819 DOI: 10.1016/S0076-6879(10)70016-1  0.717
2010 Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (New York, N.Y.). 329: 1492-9. PMID 20847263 DOI: 10.1126/Science.1188015  0.423
2010 Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature. 466: 774-8. PMID 20686576 DOI: 10.1038/Nature09301  0.429
2010 Amador-Noguez D, Feng XJ, Fan J, Roquet N, Rabitz H, Rabinowitz JD. Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum. Journal of Bacteriology. 192: 4452-61. PMID 20622067 DOI: 10.1128/Jb.00490-10  0.455
2010 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... Rabinowitz JD, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 465: 966. PMID 20559394 DOI: 10.1038/nature09132  0.528
2010 Kwon YK, Higgins MB, Rabinowitz JD. Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless death in E. coli. Acs Chemical Biology. 5: 787-95. PMID 20553049 DOI: 10.1021/Cb100096F  0.332
2010 Goyal S, Yuan J, Chen T, Rabinowitz JD, Wingreen NS. Achieving optimal growth through product feedback inhibition in metabolism. Plos Computational Biology. 6: e1000802. PMID 20532205 DOI: 10.1371/Journal.Pcbi.1000802  0.424
2010 Goodarzi H, Bennett BD, Amini S, Reaves ML, Hottes AK, Rabinowitz JD, Tavazoie S. Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. Molecular Systems Biology. 6: 378. PMID 20531407 DOI: 10.1038/Msb.2010.33  0.772
2010 Lu W, Clasquin MF, Melamud E, Amador-Noguez D, Caudy AA, Rabinowitz JD. Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Analytical Chemistry. 82: 3212-21. PMID 20349993 DOI: 10.1021/Ac902837X  0.754
2010 Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 17: 225-34. PMID 20171147 DOI: 10.1016/J.Ccr.2010.01.020  0.578
2010 Monds RD, Newell PD, Wagner JC, Schwartzman JA, Lu W, Rabinowitz JD, O'Toole GA. Di-adenosine tetraphosphate (Ap4A) metabolism impacts biofilm formation by Pseudomonas fluorescens via modulation of c-di-GMP-dependent pathways. Journal of Bacteriology. 192: 3011-23. PMID 20154123 DOI: 10.1128/Jb.01571-09  0.387
2010 Lu X, Bennet B, Mu E, Rabinowitz J, Kang Y. Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model Journal of Biological Chemistry. 285: 9317-9321. PMID 20139083 DOI: 10.1074/Jbc.C110.104448  0.377
2010 Boer VM, Crutchfield CA, Bradley PH, Botstein D, Rabinowitz JD. Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations. Molecular Biology of the Cell. 21: 198-211. PMID 19889834 DOI: 10.1091/Mbc.E09-07-0597  0.798
2010 Fantin VR, Dang L, White DW, Gross S, Bittinger MA, Driggers EM, Jang HG, Jin S, Keenan MC, Marks KM, Yen KE, Ward PS, Prins RM, Liau LM, Bennett BD, ... Rabinowitz JD, et al. Abstract 33: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Cancer Research. 70: 33-33. DOI: 10.1158/1538-7445.Am10-33  0.606
2009 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... Rabinowitz JD, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 462: 739-44. PMID 19935646 DOI: 10.1038/Nature08617  0.609
2009 Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, Rabinowitz JD, Semmelhack MF, Hughson FM, Bassler BL. The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nature Chemical Biology. 5: 891-5. PMID 19838203 DOI: 10.1038/Nchembio.237  0.316
2009 Yuan J, Doucette CD, Fowler WU, Feng XJ, Piazza M, Rabitz HA, Wingreen NS, Rabinowitz JD. Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Molecular Systems Biology. 5: 302. PMID 19690571 DOI: 10.1038/Msb.2009.60  0.688
2009 Bennett BD, Kimball EH, Gao M, Osterhout R, Van Dien SJ, Rabinowitz JD. Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nature Chemical Biology. 5: 593-9. PMID 19561621 DOI: 10.1038/Nchembio.186  0.675
2009 Shinar G, Rabinowitz JD, Alon U. Robustness in glyoxylate bypass regulation. Plos Computational Biology. 5: e1000297. PMID 19266029 DOI: 10.1371/Journal.Pcbi.1000297  0.333
2009 Bradley PH, Brauer MJ, Rabinowitz JD, Troyanskaya OG. Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae. Plos Computational Biology. 5: e1000270. PMID 19180179 DOI: 10.1371/Journal.Pcbi.1000270  0.797
2008 Munger J, Bennett BD, Parikh A, Feng XJ, McArdle J, Rabitz HA, Shenk T, Rabinowitz JD. Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nature Biotechnology. 26: 1179-86. PMID 18820684 DOI: 10.1038/Nbt.1500  0.693
2008 Kwon YK, Lu W, Melamud E, Khanam N, Bognar A, Rabinowitz JD. A domino effect in antifolate drug action in Escherichia coli. Nature Chemical Biology. 4: 602-8. PMID 18724364 DOI: 10.1038/Nchembio.108  0.412
2008 Yuan J, Bennett BD, Rabinowitz JD. Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nature Protocols. 3: 1328-40. PMID 18714301 DOI: 10.1038/Nprot.2008.131  0.688
2008 Bennett BD, Yuan J, Kimball EH, Rabinowitz JD. Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nature Protocols. 3: 1299-311. PMID 18714298 DOI: 10.1038/Nprot.2008.107  0.653
2008 Lu W, Bennett BD, Rabinowitz JD. Analytical strategies for LC-MS-based targeted metabolomics. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 871: 236-42. PMID 18502704 DOI: 10.1016/J.Jchromb.2008.04.031  0.616
2008 Rabinowitz JD, Hsiao JJ, Gryncel KR, Kantrowitz ER, Feng XJ, Li G, Rabitz H. Dissecting enzyme regulation by multiple allosteric effectors: nucleotide regulation of aspartate transcarbamoylase. Biochemistry. 47: 5881-8. PMID 18454556 DOI: 10.1021/Bi8000566  0.32
2007 Rabinowitz JD, Kimball E. Acidic acetonitrile for cellular metabolome extraction from Escherichia coli. Analytical Chemistry. 79: 6167-73. PMID 17630720 DOI: 10.1021/Ac070470C  0.319
2007 Yuan J, Rabinowitz JD. Differentiating metabolites formed from de novo synthesis versus macromolecule decomposition. Journal of the American Chemical Society. 129: 9294-5. PMID 17616198 DOI: 10.1021/Ja072997C  0.413
2007 Rabinowitz JD. Cellular metabolomics of Escherchia coli. Expert Review of Proteomics. 4: 187-98. PMID 17425455 DOI: 10.1586/14789450.4.2.187  0.409
2007 Lu W, Kwon YK, Rabinowitz JD. Isotope ratio-based profiling of microbial folates. Journal of the American Society For Mass Spectrometry. 18: 898-909. PMID 17360194 DOI: 10.1016/J.Jasms.2007.01.017  0.371
2006 Munger J, Bajad SU, Coller HA, Shenk T, Rabinowitz JD. Dynamics of the cellular metabolome during human cytomegalovirus infection. Plos Pathogens. 2: e132. PMID 17173481 DOI: 10.1371/Journal.Ppat.0020132  0.43
2006 Brauer MJ, Yuan J, Bennett BD, Lu W, Kimball E, Botstein D, Rabinowitz JD. Conservation of the metabolomic response to starvation across two divergent microbes. Proceedings of the National Academy of Sciences of the United States of America. 103: 19302-7. PMID 17159141 DOI: 10.1073/Pnas.0609508103  0.67
2006 Hess DC, Lu W, Rabinowitz JD, Botstein D. Ammonium toxicity and potassium limitation in yeast. Plos Biology. 4: e351. PMID 17048990 DOI: 10.1371/Journal.Pbio.0040351  0.339
2006 Yuan J, Fowler WU, Kimball E, Lu W, Rabinowitz JD. Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nature Chemical Biology. 2: 529-30. PMID 16936719 DOI: 10.1038/Nchembio816  0.382
2006 Bajad SU, Lu W, Kimball EH, Yuan J, Peterson C, Rabinowitz JD. Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. Journal of Chromatography. A. 1125: 76-88. PMID 16759663 DOI: 10.1016/J.Chroma.2006.05.019  0.344
2006 Lu W, Kimball E, Rabinowitz JD. A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites. Journal of the American Society For Mass Spectrometry. 17: 37-50. PMID 16352439 DOI: 10.1016/J.Jasms.2005.09.001  0.353
2002 Hall FC, Rabinowitz JD, Busch R, Visconti KC, Belmares M, Patil NS, Cope AP, Patel S, McConnell HM, Mellins ED, Sonderstrup G. Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes. European Journal of Immunology. 32: 662-70. PMID 11857340 DOI: 10.1002/1521-4141(200203)32:3<662::Aid-Immu662>3.0.Co;2-5  0.447
2001 Patil NS, Pashine A, Belmares MP, Liu W, Kaneshiro B, Rabinowitz J, McConnell H, Mellins ED. Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles Journal of Immunology. 167: 7157-7168. PMID 11739539 DOI: 10.4049/Jimmunol.167.12.7157  0.432
2000 Belmares MP, Rabinowitz JD, Liu W, Mellins ED, McConnell HM. pH stability of HLA-DR4 complexes with antigenic peptides. Biochemistry. 39: 14558-66. PMID 11087411 DOI: 10.1021/Bi001544G  0.447
2000 Kasson PM, Rabinowitz JD, Schmitt L, Davis MM, McConnell HM. Kinetics of peptide binding to the class II MHC protein I-Ek. Biochemistry. 39: 1048-58. PMID 10653650 DOI: 10.1021/Bi9921337  0.444
1998 Rabinowitz JD, Vrljic M, Kasson PM, Liang MN, Busch R, Boniface JJ, Davis MM, McConnell HM. Formation of a highly peptide-receptive state of class II MHC. Immunity. 9: 699-709. PMID 9846491 DOI: 10.1016/S1074-7613(00)80667-6  0.726
1998 Boniface JJ, Rabinowitz JD, Wülfing C, Hampl J, Reich Z, Altman JD, Kantor RM, Beeson C, McConnell HM, Davis MM. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]. Immunity. 9: 459-66. PMID 9806632 DOI: 10.1016/S1074-7613(00)80629-9  0.638
1998 Lee C, Liang MN, Tate KM, Rabinowitz JD, Beeson C, Jones PP, McConnell HM. Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft. The Journal of Experimental Medicine. 187: 1505-16. PMID 9565642 DOI: 10.1084/Jem.187.9.1505  0.676
1998 Rabinowitz JD, Vacchino JF, Beeson C, McConnell HM. Potentiometric measurement of intracellular redox activity Journal of the American Chemical Society. 120: 2464-2473. DOI: 10.1021/Ja973560F  0.767
1997 Rabinowitz JD, Rigler P, Carswell-Crumpton C, Beeson C, McConnell HM. Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockade. Life Sciences. 61: PL87-94. PMID 9252253 DOI: 10.1016/S0024-3205(97)00543-2  0.669
1997 Rabinowitz JD, Tate K, Lee C, Beeson C, McConnell HM. Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex. Proceedings of the National Academy of Sciences of the United States of America. 94: 8702-7. PMID 9238041 DOI: 10.1073/Pnas.94.16.8702  0.638
1997 Wülfing C, Rabinowitz JD, Beeson C, Sjaastad MD, McConnell HM, Davis MM. Kinetics and extent of T cell activation as measured with the calcium signal. The Journal of Experimental Medicine. 185: 1815-25. PMID 9151707 DOI: 10.1084/Jem.185.10.1815  0.643
1996 Rabinowitz JD, Beeson C, Wülfing C, Tate K, Allen PM, Davis MM, McConnell HM. Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity. 5: 125-35. PMID 8769476 DOI: 10.1016/S1074-7613(00)80489-6  0.644
1996 Beeson C, Rabinowitz J, Tate K, Gütgemann I, Chien YH, Jones PP, Davis MM, McConnell HM. Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface. The Journal of Experimental Medicine. 184: 777-82. PMID 8760833 DOI: 10.1084/Jem.184.2.777  0.646
1996 Rabinowitz JD, Beeson C, Lyons DS, Davis MM, McConnell HM. Kinetic discrimination in T-cell activation. Proceedings of the National Academy of Sciences of the United States of America. 93: 1401-5. PMID 8643643 DOI: 10.1073/Pnas.93.4.1401  0.642
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