Daniel J. Leahy - Publications

Affiliations: 
Biophysics and Biophysical Chemistry Johns Hopkins University, Baltimore, MD 
Area:
Molecular studies of signal transduction
Website:
http://www.hopkinsmedicine.org/pharmacology_molecular_sciences/faculty/bios/leahy.html

91 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Kavran JM, Leahy DJ. Immunoaffinity Purification of Proteins. Methods in Enzymology. 559: 27-36. PMID 26096501 DOI: 10.1016/bs.mie.2014.11.006  0.48
2015 Li W, Koutmou KS, Leahy DJ, Li M. Systemic RNA Interference Deficiency-1 (SID-1) extracellular domain selectively binds long double-stranded RNA and is required for RNA transport by SID-1. The Journal of Biological Chemistry. PMID 26067272 DOI: 10.1074/jbc.M115.658864  0.48
2015 Zhang W, Wu J, Ward MD, Yang S, Chuang YA, Xiao M, Li R, Leahy DJ, Worley PF. Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron. 86: 490-500. PMID 25864631 DOI: 10.1016/j.neuron.2015.03.030  0.48
2015 McCabe JM, Leahy DJ. Smoothened goes molecular: new pieces in the hedgehog signaling puzzle. The Journal of Biological Chemistry. 290: 3500-7. PMID 25519909 DOI: 10.1074/jbc.R114.617936  0.48
2015 Ward MD, Leahy DJ. Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry. The Journal of Biological Chemistry. 290: 1570-9. PMID 25468910 DOI: 10.1074/jbc.M114.612085  0.48
2014 Cleveland TE, McCabe JM, Leahy DJ. Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs. Protein Expression and Purification. 104: 92-102. PMID 25261717 DOI: 10.1016/j.pep.2014.09.012  0.48
2014 Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA. Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. The Journal of Biological Chemistry. 289: 31361-72. PMID 25248746 DOI: 10.1074/jbc.M114.597153  0.48
2014 Ma HS, Nguyen B, Duffield AS, Li L, Galanis A, Williams AB, Brown PA, Levis MJ, Leahy DJ, Small D. FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia. Cancer Research. 74: 5206-17. PMID 25060518 DOI: 10.1158/0008-5472.CAN-14-1028  0.48
2014 Kavran JM, Leahy DJ. Silver staining of SDS-polyacrylamide gel. Methods in Enzymology. 541: 169-76. PMID 24674071 DOI: 10.1016/B978-0-12-420119-4.00014-8  0.48
2014 Kavran JM, Leahy DJ. Coupling antibody to cyanogen bromide-activated sepharose. Methods in Enzymology. 541: 27-34. PMID 24674060 DOI: 10.1016/B978-0-12-420119-4.00003-3  0.48
2014 King C, Sarabipour S, Byrne P, Leahy DJ, Hristova K. The FRET signatures of noninteracting proteins in membranes: simulations and experiments. Biophysical Journal. 106: 1309-17. PMID 24655506 DOI: 10.1016/j.bpj.2014.01.039  0.48
2014 Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, et al. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. Journal of the American Chemical Society. 136: 3370-3. PMID 24533830 DOI: 10.1021/ja5006674  0.48
2014 Longo PA, Kavran JM, Kim MS, Leahy DJ. Single cell cloning of a stable mammalian cell line. Methods in Enzymology. 536: 165-72. PMID 24423275 DOI: 10.1016/B978-0-12-420070-8.00014-3  0.48
2014 Kavran JM, Leahy DJ. Lysis of mammalian and Sf9 cells. Methods in Enzymology. 536: 47-52. PMID 24423265 DOI: 10.1016/B978-0-12-420070-8.00004-0  0.48
2013 Kim MS, Leahy D. Enzymatic deglycosylation of glycoproteins Methods in Enzymology. 533: 259-263. PMID 24182931 DOI: 10.1016/B978-0-12-420067-8.00019-2  0.48
2013 Longo PA, Kavran JM, Kim MS, Leahy DJ. Transient mammalian cell transfection with polyethylenimine (PEI). Methods in Enzymology. 529: 227-40. PMID 24011049 DOI: 10.1016/B978-0-12-418687-3.00018-5  0.48
2013 A Longo P, Kavran JM, Kim MS, Leahy DJ. Generating mammalian stable cell lines by electroporation. Methods in Enzymology. 529: 209-26. PMID 24011048 DOI: 10.1016/B978-0-12-418687-3.00017-3  0.48
2013 Wang Z, Raines LL, Hooy RM, Roberson H, Leahy DJ, Cole PA. Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor. Acs Chemical Biology. 8: 2372-6. PMID 24004111 DOI: 10.1021/cb4005707  0.48
2013 Leahy DJ. Piecing together the extracellular puzzle. Cell. 154: 23-5. PMID 23827672 DOI: 10.1016/j.cell.2013.06.014  0.48
2013 Leahy DJ. Magic bullets from llamas. Structure (London, England : 1993). 21: 1072-3. PMID 23823325 DOI: 10.1016/j.str.2013.06.008  0.48
2013 Han J, Ryu S, Moskowitz DM, Rothenberg D, Leahy DJ, Atzmon G, Barzilai N, Suh Y. Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. Mechanisms of Ageing and Development. 134: 478-85. PMID 23376243 DOI: 10.1016/j.mad.2013.01.005  0.48
2013 Perilla JR, Leahy DJ, Woolf TB. Molecular dynamics simulations of transitions for ECD epidermal growth factor receptors show key differences between human and drosophila forms of the receptors. Proteins. 81: 1113-26. PMID 23348956 DOI: 10.1002/prot.24257  0.48
2013 Williams AB, Nguyen B, Li L, Brown P, Levis M, Leahy D, Small D. Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors. Leukemia. 27: 48-55. PMID 22858906 DOI: 10.1038/leu.2012.191  0.48
2012 Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD. Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron. 76: 931-44. PMID 23217742 DOI: 10.1016/j.neuron.2012.10.009  0.48
2012 Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, et al. Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. Nature Genetics. 44: 1249-54. PMID 23023332 DOI: 10.1038/ng.2421  0.48
2012 Hollmén M, Liu P, Kurppa K, Wildiers H, Reinvall I, Vandorpe T, Smeets A, Deraedt K, Vahlberg T, Joensuu H, Leahy DJ, Schöffski P, Elenius K. Proteolytic processing of ErbB4 in breast cancer. Plos One. 7: e39413. PMID 22761786 DOI: 10.1371/journal.pone.0039413  0.48
2012 Lee CH, Kim MS, Chung BM, Leahy DJ, Coulombe PA. Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nature Structural & Molecular Biology. 19: 707-15. PMID 22705788 DOI: 10.1038/nsmb.2330  0.48
2012 Liu P, Cleveland TE, Bouyain S, Byrne PO, Longo PA, Leahy DJ. A single ligand is sufficient to activate EGFR dimers. Proceedings of the National Academy of Sciences of the United States of America. 109: 10861-6. PMID 22699492 DOI: 10.1073/pnas.1201114109  0.48
2012 Liu P, Bouyain S, Eigenbrot C, Leahy DJ. The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether. Protein Science : a Publication of the Protein Society. 21: 152-5. PMID 22012915 DOI: 10.1002/pro.753  0.48
2011 Wang Z, Longo PA, Tarrant MK, Kim K, Head S, Leahy DJ, Cole PA. Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nature Structural & Molecular Biology. 18: 1388-93. PMID 22101934 DOI: 10.1038/nsmb.2168  0.48
2010 Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, et al. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (New York, N.Y.). 330: 1689-92. PMID 21097901 DOI: 10.1126/science.1196154  0.48
2010 Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes & Development. 24: 2001-12. PMID 20844013 DOI: 10.1101/gad.1951710  0.48
2010 Leahy DJ. The ins and outs of EGFR asymmetry. Cell. 142: 513-5. PMID 20723751 DOI: 10.1016/j.cell.2010.08.003  0.48
2010 Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. The Journal of Biological Chemistry. 285: 24584-90. PMID 20519495 DOI: 10.1074/jbc.M110.131680  0.48
2010 Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD. A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5767-75. PMID 20410128 DOI: 10.1523/JNEUROSCI.5061-09.2010  0.48
2010 Williams EH, Pappano WN, Saunders AM, Kim MS, Leahy DJ, Beachy PA. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proceedings of the National Academy of Sciences of the United States of America. 107: 5869-74. PMID 20231458 DOI: 10.1073/pnas.1001777107  0.48
2009 Qiu C, Tarrant MK, Boronina T, Longo PA, Kavran JM, Cole RN, Cole PA, Leahy DJ. In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry. 48: 6624-32. PMID 19518076 DOI: 10.1021/bi900755n  0.48
2008 McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature. 455: 979-83. PMID 18794898 DOI: 10.1038/nature07358  0.48
2008 Mori MX, Vander Kooi CW, Leahy DJ, Yue DT. Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+. Structure (London, England : 1993). 16: 607-20. PMID 18400181 DOI: 10.1016/j.str.2008.01.011  0.48
2008 Leahy DJ. A molecular view of anti-ErbB monoclonal antibody therapy. Cancer Cell. 13: 291-3. PMID 18394550 DOI: 10.1016/j.ccr.2008.03.010  0.48
2008 Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (London, England : 1993). 16: 460-7. PMID 18334220 DOI: 10.1016/j.str.2007.12.016  0.48
2008 Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proceedings of the National Academy of Sciences of the United States of America. 105: 3438-42. PMID 18316725 DOI: 10.1073/pnas.0705467105  0.48
2008 Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science (New York, N.Y.). 319: 476-81. PMID 18218901 DOI: 10.1126/science.1151227  0.48
2008 Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ. Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site. The Journal of Biological Chemistry. 283: 2734-40. PMID 18045866 DOI: 10.1074/jbc.M703523200  0.48
2007 Leahy DJ. A monkey wrench in the kinase machine. Nature Structural & Molecular Biology. 14: 1120-1. PMID 18059449 DOI: 10.1038/nsmb1207-1120  0.48
2007 Vander Kooi CW, Jusino MA, Perman B, Neau DB, Bellamy HD, Leahy DJ. Structural basis for ligand and heparin binding to neuropilin B domains. Proceedings of the National Academy of Sciences of the United States of America. 104: 6152-7. PMID 17405859 DOI: 10.1073/pnas.0700043104  0.48
2007 Bouyain S, Leahy DJ. Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. Protein Science : a Publication of the Protein Society. 16: 654-61. PMID 17384230 DOI: 10.1110/ps.062700307  0.48
2007 Zhang F, McLellan JS, Ayala AM, Leahy DJ, Linhardt RJ. Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. Biochemistry. 46: 3933-41. PMID 17348690 DOI: 10.1021/bi6025424  0.48
2007 Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J. Mutational analysis of Norrin-Frizzled4 recognition. The Journal of Biological Chemistry. 282: 4057-68. PMID 17158104 DOI: 10.1074/jbc.M609618200  0.48
2006 Lee JC, Vivanco I, Beroukhim R, Huang JH, Feng WL, DeBiasi RM, Yoshimoto K, King JC, Nghiemphu P, Yuza Y, Xu Q, Greulich H, Thomas RK, Paez JG, Peck TC, ... ... Leahy DJ, et al. Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. Plos Medicine. 3: e485. PMID 17177598 DOI: 10.1371/journal.pmed.0030485  0.48
2006 McLellan JS, Yao S, Zheng X, Geisbrecht BV, Ghirlando R, Beachy PA, Leahy DJ. Structure of a heparin-dependent complex of Hedgehog and Ihog. Proceedings of the National Academy of Sciences of the United States of America. 103: 17208-13. PMID 17077139 DOI: 10.1073/pnas.0606738103  0.48
2005 Zweifel ME, Leahy DJ, Barrick D. Structure and Notch receptor binding of the tandem WWE domain of Deltex. Structure (London, England : 1993). 13: 1599-611. PMID 16271883 DOI: 10.1016/j.str.2005.07.015  0.48
2005 Bouyain S, Longo PA, Li S, Ferguson KM, Leahy DJ. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. Proceedings of the National Academy of Sciences of the United States of America. 102: 15024-9. PMID 16203964 DOI: 10.1073/pnas.0507591102  0.48
2005 Geisbrecht BV, Hamaoka BY, Perman B, Zemla A, Leahy DJ. The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens. The Journal of Biological Chemistry. 280: 17243-50. PMID 15691839 DOI: 10.1074/jbc.M412311200  0.48
2004 Leahy DJ. Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors. Advances in Protein Chemistry. 68: 1-27. PMID 15500857 DOI: 10.1016/S0065-3233(04)68001-6  0.48
2004 Hamaoka BY, Dann CE, Geisbrecht BV, Leahy DJ. Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A. Proceedings of the National Academy of Sciences of the United States of America. 101: 11673-8. PMID 15289613 DOI: 10.1073/pnas.0402559101  0.48
2004 Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell. 5: 317-28. PMID 15093539 DOI: 10.1016/S1535-6108(04)00083-2  0.48
2003 Zweifel ME, Leahy DJ, Hughson FM, Barrick D. Structure and stability of the ankyrin domain of the Drosophila Notch receptor. Protein Science : a Publication of the Protein Society. 12: 2622-32. PMID 14573873 DOI: 10.1110/ps.03279003  0.48
2003 Burgess AW, Cho HS, Eigenbrot C, Ferguson KM, Garrett TP, Leahy DJ, Lemmon MA, Sliwkowski MX, Ward CW, Yokoyama S. An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Molecular Cell. 12: 541-52. PMID 14527402 DOI: 10.1016/S1097-2765(03)00350-2  0.48
2003 Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ. Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. The Journal of Biological Chemistry. 278: 32561-8. PMID 12810718 DOI: 10.1074/jbc.M302943200  0.48
2003 Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 11: 507-17. PMID 12620237 DOI: 10.1016/S1097-2765(03)00047-9  0.48
2003 Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW, Leahy DJ. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 421: 756-60. PMID 12610629 DOI: 10.1038/nature01392  0.48
2002 Leahy DJ. New light on the integrin switch. Structure (London, England : 1993). 10: 1152-4. PMID 12220485 DOI: 10.1016/S0969-2126(02)00834-1  0.48
2002 Cho HS, Leahy DJ. Structure of the extracellular region of HER3 reveals an interdomain tether. Science (New York, N.Y.). 297: 1330-3. PMID 12154198 DOI: 10.1126/science.1074611  0.48
2002 Gu C, Limberg BJ, Whitaker GB, Perman B, Leahy DJ, Rosenbaum JS, Ginty DD, Kolodkin AL. Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. The Journal of Biological Chemistry. 277: 18069-76. PMID 11886873 DOI: 10.1074/jbc.M201681200  0.48
2001 Ooi SL, Dann C, Nam K, Leahy DJ, Damha MJ, Boeke JD. RNA lariat debranching enzyme. Methods in Enzymology. 342: 233-48. PMID 11586896 DOI: 10.1016/S0076-6879(01)42548-1  0.48
2001 Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature. 412: 86-90. PMID 11452312 DOI: 10.1038/35083601  0.48
2000 Leahy DJ, Dann CE, Longo P, Perman B, Ramyar KX. A mammalian expression vector for expression and purification of secreted proteins for structural studies. Protein Expression and Purification. 20: 500-6. PMID 11087690 DOI: 10.1006/prep.2000.1331  0.48
2000 Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron. 26: 143-54. PMID 10798399  0.48
1999 Fuse N, Maiti T, Wang B, Porter JA, Hall TM, Leahy DJ, Beachy PA. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proceedings of the National Academy of Sciences of the United States of America. 96: 10992-9. PMID 10500113 DOI: 10.1073/pnas.96.20.10992  0.48
1999 Leahy DJ. Structure and Function of the Developmental Signaling Molecule Hedgehog Journal of Biochemistry and Molecular Biology. 32: 103-111.  0.48
1997 Beachy PA, Cooper MK, Young KE, von Kessler DP, Park WJ, Hall TM, Leahy DJ, Porter JA. Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. Cold Spring Harbor Symposia On Quantitative Biology. 62: 191-204. PMID 9598352  0.48
1997 Leahy DJ. Implications of atomic-resolution structures for cell adhesion. Annual Review of Cell and Developmental Biology. 13: 363-93. PMID 9442878 DOI: 10.1146/annurev.cellbio.13.1.363  0.48
1997 Hall TM, Porter JA, Young KE, Koonin EV, Beachy PA, Leahy DJ. Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell. 91: 85-97. PMID 9335337 DOI: 10.1016/S0092-8674(01)80011-8  0.48
1996 Qu A, Leahy DJ. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure (London, England : 1993). 4: 931-42. PMID 8805579 DOI: 10.1016/S0969-2126(96)00100-1  0.48
1996 Leahy DJ, Aukhil I, Erickson HP. 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell. 84: 155-64. PMID 8548820 DOI: 10.1016/S0092-8674(00)81002-8  0.48
1995 Leahy DJ. A structural view of CD4 and CD8. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 17-25. PMID 7821755  0.48
1995 Sun J, Leahy DJ, Kavathas PB. Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha 2 and alpha 3 domains of MHC class I. The Journal of Experimental Medicine. 182: 1275-80. PMID 7595198 DOI: 10.1084/jem.182.5.1275  0.48
1995 Qu A, Leahy DJ. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proceedings of the National Academy of Sciences of the United States of America. 92: 10277-81. PMID 7479767  0.48
1995 Hall TM, Porter JA, Beachy PA, Leahy DJ. A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature. 378: 212-6. PMID 7477329 DOI: 10.1038/378212a0  0.48
1994 Giblin PA, Leahy DJ, Mennone J, Kavathas PB. The role of charge and multiple faces of the CD8 alpha/alpha homodimer in binding to major histocompatibility complex class I molecules: support for a bivalent model. Proceedings of the National Academy of Sciences of the United States of America. 91: 1716-20. PMID 8127870  0.48
1994 Leahy DJ, Erickson HP, Aukhil I, Joshi P, Hendrickson WA. Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine. Proteins. 19: 48-54. PMID 8066086 DOI: 10.1002/prot.340190107  0.48
1992 Leahy DJ, Axel R, Hendrickson WA. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell. 68: 1145-62. PMID 1547508 DOI: 10.1016/0092-8674(92)90085-Q  0.48
1992 Hendrickson WA, Kwong PD, Leahy DJ, Ryu SE, Yamaguchi H, Fleury S, Sékaly RP. Structural aspects of CD4 and CD8 involvement in the cellular immune response. Cold Spring Harbor Symposia On Quantitative Biology. 57: 549-56. PMID 1339692  0.48
1992 Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP. Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. Science (New York, N.Y.). 258: 987-91. PMID 1279805  0.48
1991 Theriault TP, Leahy DJ, Levitt M, McConnell HM, Rule GS. Structural and kinetic studies of the Fab fragment of a monoclonal anti-spin label antibody by nuclear magnetic resonance. Journal of Molecular Biology. 221: 257-70. PMID 1920409 DOI: 10.1016/0022-2836(91)80218-J  0.48
1991 Brünger AT, Leahy DJ, Hynes TR, Fox RO. 2.9 A resolution structure of an anti-dinitrophenyl-spin-label monoclonal antibody Fab fragment with bound hapten. Journal of Molecular Biology. 221: 239-56. PMID 1920408 DOI: 10.1016/0022-2836(91)80217-I  0.48
1989 Kuo CH, Beggs CG, Kemper PR, Bowers MT, Leahy DJ, Zare RN. Experimental measurement of the radiative lifetime of NO+ (X 1Σ+, v=1, 2 and 3) Chemical Physics Letters. 163: 291-296. DOI: 10.1016/0009-2614(89)85138-3  0.48
1988 Leahy DJ, Rule GS, Whittaker MM, McConnell HM. Sequences of 12 monoclonal anti-dinitrophenyl spin-label antibodies for NMR studies. Proceedings of the National Academy of Sciences of the United States of America. 85: 3661-5. PMID 3375235  0.48
1988 Leahy DJ, Hynes TR, McConnell HM, Fox RO. Crystallization of an anti-2,2,6,6-tetramethyl-1-piperidinyloxy-dinitrophenyl monoclonal antibody Fab fragment with and without bound hapten. Journal of Molecular Biology. 203: 829-30. PMID 3210234 DOI: 10.1016/0022-2836(88)90215-X  0.48
1987 Anglister J, Bond MW, Frey T, Leahy D, Levitt M, McConnell HM, Rule GS, Tomasello J, Whittaker M. Contribution of tryptophan residues to the combining site of a monoclonal anti dinitrophenyl spin-label antibody. Biochemistry. 26: 6058-64. PMID 3120771  0.48
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