Daniel J. Leahy - Publications

Biophysics and Biophysical Chemistry Johns Hopkins University, Baltimore, MD 
Molecular studies of signal transduction

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nature Communications. 7: 10339. PMID 26842342 DOI: 10.1038/Ncomms10339  0.323
2015 Li W, Koutmou KS, Leahy DJ, Li M. Systemic RNA Interference Deficiency-1 (SID-1) extracellular domain selectively binds long double-stranded RNA and is required for RNA transport by SID-1. The Journal of Biological Chemistry. PMID 26067272 DOI: 10.1074/Jbc.M115.658864  0.308
2015 Zhang W, Wu J, Ward MD, Yang S, Chuang YA, Xiao M, Li R, Leahy DJ, Worley PF. Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron. 86: 490-500. PMID 25864631 DOI: 10.1016/J.Neuron.2015.03.030  0.357
2015 Sun H, Luo L, Lal B, Ma X, Chen L, Fulton A, Leahy D, Laterra J, Li M. ATPS-82PROBING THE TUMORIGENIC PROPERTIES OF TWO PORE POTASSIUM CHANNELS USING INHIBITORY KCNK9 mAbs Neuro-Oncology. 17: v36.3-v36. DOI: 10.1093/Neuonc/Nov204.82  0.309
2015 Byrne P, Hristova K, Leahy D. Mechanisms of Autoinhibition and Dimerization of the EGF Receptor Family Biophysical Journal. 108: 351a. DOI: 10.1016/J.Bpj.2014.11.1922  0.404
2015 Salotto M, Singh DR, King C, Byrne P, Leahy D, Hristova K. Comparison of EGFR Dimer Stabilities in the Presence and Absence of the Ligand EGF Biophysical Journal. 108: 258a. DOI: 10.1016/J.Bpj.2014.11.1429  0.332
2014 Cleveland TE, McCabe JM, Leahy DJ. Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs. Protein Expression and Purification. 104: 92-102. PMID 25261717 DOI: 10.1016/J.Pep.2014.09.012  0.423
2014 Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ. How IGF-1 activates its receptor. Elife. 3. PMID 25255214 DOI: 10.7554/Elife.03772  0.342
2014 Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA. Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. The Journal of Biological Chemistry. 289: 31361-72. PMID 25248746 DOI: 10.1074/Jbc.M114.597153  0.358
2014 King C, Sarabipour S, Byrne P, Leahy DJ, Hristova K. The FRET signatures of noninteracting proteins in membranes: simulations and experiments. Biophysical Journal. 106: 1309-17. PMID 24655506 DOI: 10.1016/J.Bpj.2014.01.039  0.313
2014 Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, et al. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. Journal of the American Chemical Society. 136: 3370-3. PMID 24533830 DOI: 10.1021/Ja5006674  0.343
2014 Bagchi A, Bessman NJ, Wu NZ, Raines L, Kan Z, Hu W, Englander SW, Leahy DJ, Lemmon MA, Ferguson KM. Allosteric Regulation of the Epidermal Growth Factor Receptor Biophysical Journal. 106: 105a. DOI: 10.1016/J.Bpj.2013.11.650  0.33
2014 King CR, Sarabipour S, Byrne P, Leahy D, Hristova K. The FRET Signatures of Non-Interacting Proteins in Cellular Membranes Biophysical Journal. 106: 719a. DOI: 10.1016/J.Bpj.2013.11.3973  0.312
2012 Hollmén M, Liu P, Kurppa K, Wildiers H, Reinvall I, Vandorpe T, Smeets A, Deraedt K, Vahlberg T, Joensuu H, Leahy DJ, Schöffski P, Elenius K. Proteolytic processing of ErbB4 in breast cancer. Plos One. 7: e39413. PMID 22761786 DOI: 10.1371/Journal.Pone.0039413  0.302
2012 Lee CH, Kim MS, Chung BM, Leahy DJ, Coulombe PA. Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nature Structural & Molecular Biology. 19: 707-15. PMID 22705788 DOI: 10.1038/Nsmb.2330  0.318
2012 Liu P, Cleveland TE, Bouyain S, Byrne PO, Longo PA, Leahy DJ. A single ligand is sufficient to activate EGFR dimers. Proceedings of the National Academy of Sciences of the United States of America. 109: 10861-6. PMID 22699492 DOI: 10.1073/Pnas.1201114109  0.352
2012 Liu P, Bouyain S, Eigenbrot C, Leahy DJ. The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether. Protein Science : a Publication of the Protein Society. 21: 152-5. PMID 22012915 DOI: 10.1002/Pro.753  0.424
2011 Wang Z, Longo PA, Tarrant MK, Kim K, Head S, Leahy DJ, Cole PA. Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nature Structural & Molecular Biology. 18: 1388-93. PMID 22101934 DOI: 10.1038/Nsmb.2168  0.318
2011 Kim MS, Saunders AM, Hamaoka BY, Beachy PA, Leahy DJ. Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 13112-7. PMID 21828006 DOI: 10.1073/Pnas.1109877108  0.752
2011 Perilla JR, Leahy D, Woolf TB. Dynamic Importance Sampling Calculations on ECD Epitelial Growth Factor Receptor Conformational Changes Biophysical Journal. 100: 256a. DOI: 10.1016/J.Bpj.2010.12.1613  0.364
2010 Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes & Development. 24: 2001-12. PMID 20844013 DOI: 10.1101/Gad.1951710  0.391
2010 Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. The Journal of Biological Chemistry. 285: 24584-90. PMID 20519495 DOI: 10.1074/Jbc.M110.131680  0.45
2010 Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD. A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5767-75. PMID 20410128 DOI: 10.1523/Jneurosci.5061-09.2010  0.357
2010 Williams EH, Pappano WN, Saunders AM, Kim MS, Leahy DJ, Beachy PA. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proceedings of the National Academy of Sciences of the United States of America. 107: 5869-74. PMID 20231458 DOI: 10.1073/Pnas.1001777107  0.376
2009 Qiu C, Tarrant MK, Boronina T, Longo PA, Kavran JM, Cole RN, Cole PA, Leahy DJ. In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry. 48: 6624-32. PMID 19518076 DOI: 10.1021/Bi900755N  0.311
2008 McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature. 455: 979-83. PMID 18794898 DOI: 10.1038/Nature07358  0.646
2008 Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (London, England : 1993). 16: 460-7. PMID 18334220 DOI: 10.1016/J.Str.2007.12.016  0.343
2008 Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science (New York, N.Y.). 319: 476-81. PMID 18218901 DOI: 10.1126/Science.1151227  0.327
2007 Vander Kooi CW, Jusino MA, Perman B, Neau DB, Bellamy HD, Leahy DJ. Structural basis for ligand and heparin binding to neuropilin B domains. Proceedings of the National Academy of Sciences of the United States of America. 104: 6152-7. PMID 17405859 DOI: 10.1073/Pnas.0700043104  0.418
2007 Zhang F, McLellan JS, Ayala AM, Leahy DJ, Linhardt RJ. Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. Biochemistry. 46: 3933-41. PMID 17348690 DOI: 10.1021/Bi6025424  0.62
2007 Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J. Mutational analysis of Norrin-Frizzled4 recognition. The Journal of Biological Chemistry. 282: 4057-68. PMID 17158104 DOI: 10.1074/Jbc.M609618200  0.449
2006 McLellan JS, Yao S, Zheng X, Geisbrecht BV, Ghirlando R, Beachy PA, Leahy DJ. Structure of a heparin-dependent complex of Hedgehog and Ihog. Proceedings of the National Academy of Sciences of the United States of America. 103: 17208-13. PMID 17077139 DOI: 10.1073/Pnas.0606738103  0.635
2005 Zweifel ME, Leahy DJ, Barrick D. Structure and Notch receptor binding of the tandem WWE domain of Deltex. Structure (London, England : 1993). 13: 1599-611. PMID 16271883 DOI: 10.1016/J.Str.2005.07.015  0.461
2005 Bouyain S, Longo PA, Li S, Ferguson KM, Leahy DJ. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. Proceedings of the National Academy of Sciences of the United States of America. 102: 15024-9. PMID 16203964 DOI: 10.1073/Pnas.0507591102  0.366
2005 Geisbrecht BV, Hamaoka BY, Perman B, Zemla A, Leahy DJ. The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens. The Journal of Biological Chemistry. 280: 17243-50. PMID 15691839 DOI: 10.1074/Jbc.M412311200  0.752
2004 Hamaoka BY, Dann CE, Geisbrecht BV, Leahy DJ. Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A. Proceedings of the National Academy of Sciences of the United States of America. 101: 11673-8. PMID 15289613 DOI: 10.1073/Pnas.0402559101  0.72
2003 Zweifel ME, Leahy DJ, Hughson FM, Barrick D. Structure and stability of the ankyrin domain of the Drosophila Notch receptor. Protein Science : a Publication of the Protein Society. 12: 2622-32. PMID 14573873 DOI: 10.1110/Ps.03279003  0.452
2003 Burgess AW, Cho HS, Eigenbrot C, Ferguson KM, Garrett TP, Leahy DJ, Lemmon MA, Sliwkowski MX, Ward CW, Yokoyama S. An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Molecular Cell. 12: 541-52. PMID 14527402 DOI: 10.1016/S1097-2765(03)00350-2  0.342
2003 Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ. Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. The Journal of Biological Chemistry. 278: 32561-8. PMID 12810718 DOI: 10.1074/Jbc.M302943200  0.377
2003 Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 11: 507-17. PMID 12620237 DOI: 10.1016/S1097-2765(03)00047-9  0.393
2003 Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW, Leahy DJ. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 421: 756-60. PMID 12610629 DOI: 10.1038/Nature01392  0.358
2002 Gu C, Limberg BJ, Whitaker GB, Perman B, Leahy DJ, Rosenbaum JS, Ginty DD, Kolodkin AL. Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. The Journal of Biological Chemistry. 277: 18069-76. PMID 11886873 DOI: 10.1074/Jbc.M201681200  0.411
2001 Ooi SL, Dann C, Nam K, Leahy DJ, Damha MJ, Boeke JD. RNA lariat debranching enzyme. Methods in Enzymology. 342: 233-48. PMID 11586896 DOI: 10.1016/S0076-6879(01)42548-1  0.649
2001 Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature. 412: 86-90. PMID 11452312 DOI: 10.1038/35083601  0.734
2000 Leahy DJ, Dann CE, Longo P, Perman B, Ramyar KX. A mammalian expression vector for expression and purification of secreted proteins for structural studies. Protein Expression and Purification. 20: 500-6. PMID 11087690 DOI: 10.1006/Prep.2000.1331  0.693
2000 Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron. 26: 143-54. PMID 10798399 DOI: 10.1016/S0896-6273(00)81145-9  0.703
1999 Fuse N, Maiti T, Wang B, Porter JA, Hall TM, Leahy DJ, Beachy PA. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proceedings of the National Academy of Sciences of the United States of America. 96: 10992-9. PMID 10500113 DOI: 10.1073/Pnas.96.20.10992  0.426
1997 Beachy PA, Cooper MK, Young KE, von Kessler DP, Park WJ, Hall TM, Leahy DJ, Porter JA. Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. Cold Spring Harbor Symposia On Quantitative Biology. 62: 191-204. PMID 9598352 DOI: 10.1101/Sqb.1997.062.01.025  0.318
1997 Hall TM, Porter JA, Young KE, Koonin EV, Beachy PA, Leahy DJ. Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell. 91: 85-97. PMID 9335337 DOI: 10.1016/S0092-8674(01)80011-8  0.414
1996 Qu A, Leahy DJ. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure (London, England : 1993). 4: 931-42. PMID 8805579 DOI: 10.1016/S0969-2126(96)00100-1  0.428
1996 Leahy DJ, Aukhil I, Erickson HP. 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell. 84: 155-64. PMID 8548820 DOI: 10.1016/S0092-8674(00)81002-8  0.438
1995 Qu A, Leahy DJ. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proceedings of the National Academy of Sciences of the United States of America. 92: 10277-81. PMID 7479767 DOI: 10.1073/Pnas.92.22.10277  0.409
1995 Hall TM, Porter JA, Beachy PA, Leahy DJ. A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature. 378: 212-6. PMID 7477329 DOI: 10.1038/378212A0  0.455
1994 Leahy DJ, Erickson HP, Aukhil I, Joshi P, Hendrickson WA. Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine. Proteins. 19: 48-54. PMID 8066086 DOI: 10.1002/Prot.340190107  0.322
1992 Leahy DJ, Axel R, Hendrickson WA. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell. 68: 1145-62. PMID 1547508 DOI: 10.1016/0092-8674(92)90085-Q  0.381
1992 Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP. Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. Science (New York, N.Y.). 258: 987-91. PMID 1279805 DOI: 10.1126/Science.1279805  0.449
1991 Theriault TP, Leahy DJ, Levitt M, McConnell HM, Rule GS. Structural and kinetic studies of the Fab fragment of a monoclonal anti-spin label antibody by nuclear magnetic resonance. Journal of Molecular Biology. 221: 257-70. PMID 1920409 DOI: 10.1016/0022-2836(91)80218-J  0.67
1988 Leahy DJ, Rule GS, Whittaker MM, McConnell HM. Sequences of 12 monoclonal anti-dinitrophenyl spin-label antibodies for NMR studies. Proceedings of the National Academy of Sciences of the United States of America. 85: 3661-5. PMID 3375235 DOI: 10.1073/Pnas.85.11.3661  0.633
1988 Leahy DJ, Hynes TR, McConnell HM, Fox RO. Crystallization of an anti-2,2,6,6-tetramethyl-1-piperidinyloxy-dinitrophenyl monoclonal antibody Fab fragment with and without bound hapten. Journal of Molecular Biology. 203: 829-30. PMID 3210234 DOI: 10.1016/0022-2836(88)90215-X  0.407
1987 Anglister J, Bond MW, Frey T, Leahy D, Levitt M, McConnell HM, Rule GS, Tomasello J, Whittaker M. Contribution of tryptophan residues to the combining site of a monoclonal anti dinitrophenyl spin-label antibody. Biochemistry. 26: 6058-64. PMID 3120771 DOI: 10.1021/Bi00393A017  0.626
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