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Matthew L. Bettini, Ph.D. - Publications

Affiliations: 
2008 Emory University, Atlanta, GA 
Area:
Immunology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jing Y, Kong Y, Allard D, Liu B, Kolawole E, Sprouse M, Evavold B, Bettini M, Bettini M. Increased TCR signaling in regulatory T cells is disengaged from TCR affinity. Biorxiv : the Preprint Server For Biology. PMID 36711832 DOI: 10.1101/2023.01.17.523999  0.508
2022 Szwarc MM, Hai L, Maurya VK, Rajapakshe K, Perera D, Ittmann MM, Mo Q, Lin Y, Bettini ML, Coarfa C, Lydon JP. Histopathologic and transcriptomic phenotypes of a conditional RANKL transgenic mouse thymus. Cytokine. 160: 156022. PMID 36099756 DOI: 10.1016/j.cyto.2022.156022  0.434
2022 Majumdar S, Lin Y, Bettini ML. Host-microbiota interactions shaping T-cell response and tolerance in type 1 diabetes. Frontiers in Immunology. 13: 974178. PMID 36059452 DOI: 10.3389/fimmu.2022.974178  0.313
2022 Lin Y, Perovanovic J, Kong Y, Igyarto BZ, Zurawski S, Tantin D, Zurawski G, Bettini M, Bettini ML. Antibody-Mediated Targeting of a Hybrid-Insulin-Peptide Towards Neonatal Thymic Langerin+ Cells Enhances T Cell Central Tolerance and Delays Autoimmune Diabetes. Diabetes. PMID 35622068 DOI: 10.2337/db21-1069  0.353
2022 Kong Y, Jing Y, Allard D, Scavuzzo MA, Sprouse ML, Borowiak M, Bettini ML, Bettini M. A dormant T-cell population with autoimmune potential exhibits low self-reactivity and infiltrates islets in type 1 diabetes. European Journal of Immunology. PMID 35389516 DOI: 10.1002/eji.202149690  0.555
2022 Jing Y, Kong Y, McGinty J, Blahnik-Fagan G, Lee T, Orozco-Figueroa S, Bettini ML, James EA, Bettini M. TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Post-translationally Modified GAD65 Epitope. Diabetes. PMID 35179565 DOI: 10.2337/db21-0993  0.541
2021 Zegarra-Ruiz DF, Kim DV, Norwood K, Kim M, Wu WH, Saldana-Morales FB, Hill AA, Majumdar S, Orozco S, Bell R, Round JL, Longman RS, Egawa T, Bettini ML, Diehl GE. Thymic development of gut-microbiota-specific T cells. Nature. PMID 33981034 DOI: 10.1038/s41586-021-03531-1  0.381
2020 Ramstead AG, Wallace JA, Lee SH, Bauer KM, Tang WW, Ekiz HA, Lane TE, Cluntun AA, Bettini ML, Round JL, Rutter J, O'Connell RM. Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell Reports. 30: 2889-2899.e6. PMID 32130894 DOI: 10.1016/J.Celrep.2020.02.042  0.464
2020 Jing Y, Kong Y, Mcginty J, Blahnik-Fagan G, Bettini M, James EA, Bettini M. 287-OR: TCR/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope Diabetes. 69. DOI: 10.2337/Db20-287-Or  0.346
2019 Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini ML. A Critical Insulin TCR Contact Residue Selects High Affinity and Pathogenic Insulin Specific T Cells. Diabetes. PMID 31836691 DOI: 10.2337/Db19-0821  0.427
2018 Kim M, Galan C, Hill AA, Wu WJ, Fehlner-Peach H, Song HW, Schady D, Bettini ML, Simpson KW, Longman RS, Littman DR, Diehl GE. Critical Role for the Microbiota in CXCR1 Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses. Immunity. PMID 29980437 DOI: 10.1016/J.Immuni.2018.05.009  0.413
2018 Sprouse ML, Scavuzzo MA, Blum S, Shevchenko I, Lee T, Makedonas G, Borowiak M, Bettini ML, Bettini M. High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity. Jci Insight. 3. PMID 29367462 DOI: 10.1172/Jci.Insight.97322  0.519
2018 Lin Y, Lee T, Bettini M, Bettini M. Thymic Development of Beta-Cell Specific Regulatory T Cells in Neonatal NOD Mice Diabetes. 67. DOI: 10.2337/Db18-316-Or  0.544
2018 KONG Y, SPROUSE ML, JING Y, BETTINI M, BETTINI M. Self-Reactivity and T-Cell Receptor Repertoire of Effector and Regulatory T Cells in Autoimmune Diabetes Diabetes. 67: 2418-PUB. DOI: 10.2337/Db18-2418-Pub  0.563
2017 Bettini ML, Bettini M. Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex. Frontiers in Endocrinology. 8: 351. PMID 29312143 DOI: 10.3389/Fendo.2017.00351  0.486
2017 Sprouse ML, Shevchenko I, Scavuzzo MA, Joseph F, Lee T, Blum S, Borowiak M, Bettini ML, Bettini M. Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). PMID 29282307 DOI: 10.4049/Jimmunol.1700156  0.507
2017 Sprouse ML, Blahnik G, Lee T, Tully N, Benarjee P, James EA, Redondo MJ, Bettini ML, Bettini M. Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs. Journal of Visualized Experiments : Jove. PMID 28930975 DOI: 10.3791/55379  0.419
2017 Lee T, Sprouse ML, Banerjee P, Bettini M, Bettini ML. Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 28835461 DOI: 10.4049/Jimmunol.1700207  0.559
2017 Bettini ML, Chou PC, Guy CS, Lee T, Vignali KM, Vignali DAA. Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development. Journal of Immunology (Baltimore, Md. : 1950). PMID 28733484 DOI: 10.4049/Jimmunol.1700069  0.49
2016 Sprouse ML, Blahnik G, Lee T, Tully N, Banerjee P, James EA, Redondo MJ, Bettini ML, Bettini M. Rapid identification and expression of human TCRs in retrogenic mice. Journal of Immunological Methods. PMID 27589924 DOI: 10.1016/J.Jim.2016.08.010  0.467
2016 Lee T, Shevchenko I, Sprouse ML, Bettini M, Bettini ML. Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice. Journal of Visualized Experiments : Jove. PMID 27500835 DOI: 10.3791/54196  0.533
2015 Paust S, Bettini M. Daring to learn from humanized mice. Blood. 125: 3829-31. PMID 26089378 DOI: 10.1182/Blood-2015-04-639435  0.33
2014 Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA. Membrane association of the CD3ε signaling domain is required for optimal T cell development and function. Journal of Immunology (Baltimore, Md. : 1950). 193: 258-67. PMID 24899501 DOI: 10.4049/Jimmunol.1400322  0.574
2013 Bettini ML, Bettini M, Nakayama M, Guy CS, Vignali DA. Generation of T cell receptor-retrogenic mice: improved retroviral-mediated stem cell gene transfer. Nature Protocols. 8: 1837-40. PMID 24008379 DOI: 10.1038/Nprot.2013.111  0.342
2013 Delgoffe GM, Woo SR, Turnis ME, Gravano DM, Guy C, Overacre AE, Bettini ML, Vogel P, Finkelstein D, Bonnevier J, Workman CJ, Vignali DA. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature. 501: 252-6. PMID 23913274 DOI: 10.1038/Nature12428  0.48
2013 Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, et al. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nature Immunology. 14: 262-70. PMID 23377202 DOI: 10.1038/Ni.2538  0.564
2012 Delgoffe GM, Bettini ML, Vignali DA. Identity crisis: it's not just Foxp3 anymore. Immunity. 37: 759-61. PMID 23159220 DOI: 10.1016/J.Immuni.2012.10.012  0.474
2012 Bettini ML, Pan F, Bettini M, Finkelstein D, Rehg JE, Floess S, Bell BD, Ziegler SF, Huehn J, Pardoll DM, Vignali DA. Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity. 36: 717-30. PMID 22579476 DOI: 10.1016/J.Immuni.2012.03.020  0.476
2012 Bettini ML, Bettini M, Vignali DA. T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice. Immunology. 136: 265-72. PMID 22348644 DOI: 10.1111/J.1365-2567.2012.03574.X  0.588
2012 Woo SR, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, Bettini ML, Gravano DM, Vogel P, Liu CL, Tangsombatvisit S, Grosso JF, Netto G, Smeltzer MP, Chaux A, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Research. 72: 917-27. PMID 22186141 DOI: 10.1158/0008-5472.Can-11-1620  0.395
2011 Goldberg MV, Woo S, Bankoti J, Selby M, Nirschl CJ, Bettini ML, Vogel P, Grosso JF, Netto G, Chaux A, Smeltzer M, Workman CJ, Pardoll DM, Korman AJ, Vignali DA, et al. Abstract LB-251: The checkpoint molecules LAG-3 and PD-1 synergize to maintain tolerance to tumors Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-251  0.369
2010 Wang H, Holst J, Woo SR, Guy C, Bettini M, Wang Y, Shafer A, Naramura M, Mingueneau M, Dragone LL, Hayes SM, Malissen B, Band H, Vignali DA. Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. The Embo Journal. 29: 1285-98. PMID 20150895 DOI: 10.1038/Emboj.2010.10  0.604
2010 Bettini ML, Vignali DA. Development of thymically derived natural regulatory T cells. Annals of the New York Academy of Sciences. 1183: 1-12. PMID 20146704 DOI: 10.1111/J.1749-6632.2009.05129.X  0.486
2007 Bettini ML, Kersh GJ. MAP kinase phosphatase activity sets the threshold for thymocyte positive selection. Proceedings of the National Academy of Sciences of the United States of America. 104: 16257-62. PMID 17901205 DOI: 10.1073/Pnas.0705321104  0.63
2003 Bettini M, Xi H, Kersh GJ. T cell stimulation in the absence of exogenous antigen: a T cell signal is induced by both MHC-dependent and -independent mechanisms. European Journal of Immunology. 33: 3109-16. PMID 14579279 DOI: 10.1002/Eji.200324067  0.649
2002 Bettini M, Xi H, Milbrandt J, Kersh GJ. Thymocyte development in early growth response gene 1-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 169: 1713-20. PMID 12165491 DOI: 10.4049/Jimmunol.169.4.1713  0.635
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