| Year |
Citation |
Score |
| 2009 |
Hong H, Leadlay PF, Staunton J. The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry. The Febs Journal. 276: 7057-69. PMID 19860832 DOI: 10.1111/J.1742-4658.2009.07418.X |
0.568 |
|
| 2008 |
Kellenberger L, Galloway IS, Sauter G, Böhm G, Hanefeld U, Cortés J, Staunton J, Leadlay PF. A polylinker approach to reductive loop swaps in modular polyketide synthases. Chembiochem : a European Journal of Chemical Biology. 9: 2740-9. PMID 18937219 DOI: 10.1002/Cbic.200800332 |
0.577 |
|
| 2008 |
Demydchuk Y, Sun Y, Hong H, Staunton J, Spencer JB, Leadlay PF. Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem : a European Journal of Chemical Biology. 9: 1136-45. PMID 18404760 DOI: 10.1002/Cbic.200700715 |
0.556 |
|
| 2006 |
Harvey BM, Hong H, Jones MA, Hughes-Thomas ZA, Goss RM, Heathcote ML, Bolanos-Garcia VM, Kroutil W, Staunton J, Leadlay PF, Spencer JB. Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. Chembiochem : a European Journal of Chemical Biology. 7: 1435-42. PMID 16897798 DOI: 10.1002/Cbic.200500474 |
0.575 |
|
| 2006 |
Gallimore AR, Stark CB, Bhatt A, Harvey BM, Demydchuk Y, Bolanos-Garcia V, Fowler DJ, Staunton J, Leadlay PF, Spencer JB. Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chemistry & Biology. 13: 453-60. PMID 16632258 DOI: 10.1016/J.Chembiol.2006.01.013 |
0.588 |
|
| 2005 |
Siskos AP, Baerga-Ortiz A, Bali S, Stein V, Mamdani H, Spiteller D, Popovic B, Spencer JB, Staunton J, Weissman KJ, Leadlay PF. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chemistry & Biology. 12: 1145-53. PMID 16242657 DOI: 10.1016/J.Chembiol.2005.08.017 |
0.589 |
|
| 2005 |
Bhatt A, Stark CB, Harvey BM, Gallimore AR, Demydchuk YA, Spencer JB, Staunton J, Leadlay PF. Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked. Angewandte Chemie (International Ed. in English). 44: 7075-8. PMID 16217816 DOI: 10.1002/Anie.200501757 |
0.483 |
|
| 2005 |
Hong H, Appleyard AN, Siskos AP, Garcia-Bernardo J, Staunton J, Leadlay PF. Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry. The Febs Journal. 272: 2373-87. PMID 15885088 DOI: 10.1111/J.1742-4658.2005.04615.X |
0.559 |
|
| 2004 |
Boakes S, Oliynyk M, Cortés J, Böhm I, Rudd BA, Revill WP, Staunton J, Leadlay PF. A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea. Journal of Molecular Microbiology and Biotechnology. 8: 73-80. PMID 15925898 DOI: 10.1159/000084562 |
0.782 |
|
| 2004 |
Lowden PA, Böhm GA, Metcalfe S, Staunton J, Leadlay PF. New rapamycin derivatives by precursor-directed biosynthesis. Chembiochem : a European Journal of Chemical Biology. 5: 535-8. PMID 15185378 DOI: 10.1002/Cbic.200300758 |
0.524 |
|
| 2004 |
Gregory MA, Gaisser S, Lill RE, Hong H, Sheridan RM, Wilkinson B, Petkovic H, Weston AJ, Carletti I, Lee HL, Staunton J, Leadlay PF. Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus. Angewandte Chemie (International Ed. in English). 43: 2551-3. PMID 15127450 DOI: 10.1002/Anie.200453764 |
0.689 |
|
| 2004 |
Gregory M, Gaisser S, Lill R, Hong H, Wilkinson B, Petkovic H, Sheridan R, Staunton J, Leadlay P, Zhang M. 566 Novel mTOR inhibitors with improved pharmacological properties over rapamycin European Journal of Cancer Supplements. 2: 172. DOI: 10.1016/S1359-6349(04)80574-3 |
0.415 |
|
| 2003 |
Martin CJ, Timoney MC, Sheridan RM, Kendrew SG, Wilkinson B, Staunton JC, Leadlay PF. Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase. Organic & Biomolecular Chemistry. 1: 4144-7. PMID 14685317 DOI: 10.1039/B310740J |
0.7 |
|
| 2003 |
Hong H, Gates PJ, Staunton J, Stinear T, Cole ST, Leadlay PF, Spencer JB. Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans. Chemical Communications (Cambridge, England). 2822-3. PMID 14651122 DOI: 10.1039/B308163J |
0.524 |
|
| 2003 |
Squire CM, Goss RJ, Hong H, Leadlay PF, Staunton J. Catalytically active tetramodular 6-deoxyerythonolide B synthase fusion proteins. Chembiochem : a European Journal of Chemical Biology. 4: 1225-8. PMID 14613116 DOI: 10.1002/Cbic.200300671 |
0.507 |
|
| 2003 |
Hughes-Thomas ZA, Stark CB, Böhm IU, Staunton J, Leadlay PF. Intermediates released from a polyether-producing polyketide synthase provide insight into the mechanism of oxidative cyclization. Angewandte Chemie (International Ed. in English). 42: 4475-8. PMID 14520742 DOI: 10.1002/Anie.200351375 |
0.507 |
|
| 2003 |
Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall K, McArthur HA, Staunton J, Leadlay PF. Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. Organic & Biomolecular Chemistry. 1: 2840-7. PMID 12968333 DOI: 10.1039/B304022D |
0.7 |
|
| 2003 |
Oliynyk M, Stark CB, Bhatt A, Jones MA, Hughes-Thomas ZA, Wilkinson C, Oliynyk Z, Demydchuk Y, Staunton J, Leadlay PF. Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. Molecular Microbiology. 49: 1179-90. PMID 12940979 DOI: 10.1046/J.1365-2958.2003.03571.X |
0.562 |
|
| 2003 |
Petkovic H, Lill RE, Sheridan RM, Wilkinson B, McCormick EL, McArthur HA, Staunton J, Leadlay PF, Kendrew SG. A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase. The Journal of Antibiotics. 56: 543-51. PMID 12931864 DOI: 10.7164/Antibiotics.56.543 |
0.71 |
|
| 2003 |
Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortés J, Rudd BA, Staunton J, Leadlay PF. Active-site residue, domain and module swaps in modular polyketide synthases. Journal of Industrial Microbiology & Biotechnology. 30: 489-94. PMID 12811585 DOI: 10.1007/S10295-003-0062-0 |
0.767 |
|
| 2003 |
Paz F, Gates PJ, Fowler S, Gallimore A, Harvey B, Lopes N, Stark C, Staunton J, Klinowski J, Spencer J. Sodium Monensin Dihydrate: A Second Polymorph Acta Crystallographica Section E-Structure Reports Online. 59. DOI: 10.1007/S1600536803022980 |
0.737 |
|
| 2002 |
Thomas I, Martin CJ, Wilkinson CJ, Staunton J, Leadlay PF. Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer. Chemistry & Biology. 9: 781-7. PMID 12144921 DOI: 10.1016/S1074-5521(02)00164-3 |
0.564 |
|
| 2002 |
Wilkinson CJ, Hughes-Thomas ZA, Martin CJ, Böhm I, Mironenko T, Deacon M, Wheatcroft M, Wirtz G, Staunton J, Leadlay PF. Increasing the efficiency of heterologous promoters in actinomycetes. Journal of Molecular Microbiology and Biotechnology. 4: 417-26. PMID 12125822 |
0.475 |
|
| 2002 |
Gaisser S, Martin CJ, Wilkinson B, Sheridan RM, Lill RE, Weston AJ, Ready SJ, Waldron C, Crouse GD, Leadlay PF, Staunton J. Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents. Chemical Communications (Cambridge, England). 618-9. PMID 12120151 DOI: 10.1039/B200536K |
0.682 |
|
| 2002 |
Gaisser S, Lill R, Staunton J, Méndez C, Salas J, Leadlay PF. Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. Molecular Microbiology. 44: 771-81. PMID 11994157 DOI: 10.1046/J.1365-2958.2002.02910.X |
0.518 |
|
| 2002 |
Long PF, Wilkinson CJ, Bisang CP, Cortés J, Dunster N, Oliynyk M, McCormick E, McArthur H, Mendez C, Salas JA, Staunton J, Leadlay PF. Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Molecular Microbiology. 43: 1215-25. PMID 11918808 DOI: 10.1046/J.1365-2958.2002.02815.X |
0.577 |
|
| 2002 |
Østergaard LH, Kellenberger L, Cortés J, Roddis MP, Deacon M, Staunton J, Leadlay PF. Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase. Biochemistry. 41: 2719-26. PMID 11851419 DOI: 10.1021/Bi0117605 |
0.595 |
|
| 2002 |
Hong H, Østergaard L, Heathcote ML, Staunton J, Leadlay PF. Investigation of malfunction in an engineered polyketide synthase by proteolysis and LC-MS Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 355-356. |
0.425 |
|
| 2001 |
Leadlay PF, Staunton J, Oliynyk M, Bisang C, Cortés J, Frost E, Hughes-Thomas ZA, Jones MA, Kendrew SG, Lester JB, Long PF, McArthur HA, McCormick EL, Oliynyk Z, Stark CB, et al. Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster. Journal of Industrial Microbiology & Biotechnology. 27: 360-7. PMID 11774001 DOI: 10.1038/Sj.Jim.7000204 |
0.783 |
|
| 2001 |
Wilkinson CJ, Frost EJ, Staunton J, Leadlay PF. Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum. Chemistry & Biology. 8: 1197-208. PMID 11755398 DOI: 10.1016/S1074-5521(01)00087-4 |
0.585 |
|
| 2001 |
Gaisser S, Lill R, Wirtz G, Grolle F, Staunton J, Leadlay PF. New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster. Molecular Microbiology. 41: 1223-31. PMID 11555300 DOI: 10.1046/J.1365-2958.2001.02594.X |
0.514 |
|
| 2001 |
Rowe CJ, Böhm IU, Thomas IP, Wilkinson B, Rudd BA, Foster G, Blackaby AP, Sidebottom PJ, Roddis Y, Buss AD, Staunton J, Leadlay PF. Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase. Chemistry & Biology. 8: 475-85. PMID 11358694 DOI: 10.1016/S1074-5521(01)00024-2 |
0.593 |
|
| 2001 |
Holzbaur IE, Ranganathan A, Thomas IP, Kearney DJ, Reather JA, Rudd BA, Staunton J, Leadlay PF. Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates. Chemistry & Biology. 8: 329-40. PMID 11325589 DOI: 10.1016/S1074-5521(01)00014-X |
0.588 |
|
| 2001 |
Heathcote ML, Staunton J, Leadlay PF. Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units. Chemistry & Biology. 8: 207-20. PMID 11251294 DOI: 10.1016/S1074-5521(01)00002-3 |
0.553 |
|
| 2001 |
Lowden PA, Wilkinson B, Böhm GA, Handa S, Floss HG, Leadlay PF, Staunton J. Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase We thank Dr. Bradley S. Moore for help with the deuterium NMR experiments. This work was supported by grants from The Wellcome Trust (to J.S. and P.F.L.) and from the NIH (AI20264 to H.G.F.). Angewandte Chemie (International Ed. in English). 40: 777-779. PMID 11241621 DOI: 10.1002/1521-3773(20010216)40:4<777::Aid-Anie7770>3.0.Co;2-9 |
0.719 |
|
| 2000 |
Gaisser S, Reather J, Wirtz G, Kellenberger L, Staunton J, Leadlay PF. A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea. Molecular Microbiology. 36: 391-401. PMID 10792725 DOI: 10.1046/J.1365-2958.2000.01856.X |
0.564 |
|
| 2000 |
Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Böhm IU, Rowe CJ, Cortés J, Leadlay PF, Staunton J. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. Chemistry & Biology. 7: 111-7. PMID 10662692 DOI: 10.1016/S1074-5521(00)00076-4 |
0.588 |
|
| 2000 |
Bycroft M, Weissman KJ, Staunton J, Leadlay PF. Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase. European Journal of Biochemistry / Febs. 267: 520-6. PMID 10632721 DOI: 10.1046/J.1432-1327.2000.01025.X |
0.592 |
|
| 1999 |
Weissman KJ, Kearney GC, Leadlay PF, Staunton J. Structural elucidation studies of polyketide tetrasubstituted delta-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry Rapid Communications in Mass Spectrometry : Rcm. 13: 2103-8. PMID 10523767 DOI: 10.1002/(Sici)1097-0231(19991115)13:21<2103::Aid-Rcm760>3.0.Co;2-Y |
0.5 |
|
| 1999 |
Bisang C, Long PF, Cortés J, Westcott J, Crosby J, Matharu AL, Cox RJ, Simpson TJ, Staunton J, Leadlay PF. A chain initiation factor common to both modular and aromatic polyketide synthases. Nature. 401: 502-5. PMID 10519556 DOI: 10.1038/46829 |
0.552 |
|
| 1999 |
Ranganathan A, Timoney M, Bycroft M, Cortés J, Thomas IP, Wilkinson B, Kellenberger L, Hanefeld U, Galloway IS, Staunton J, Leadlay PF. Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues. Chemistry & Biology. 6: 731-41. PMID 10508677 DOI: 10.1016/S1074-5521(00)80020-4 |
0.569 |
|
| 1999 |
Kearney GC, Gates PJ, Leadlay PF, Staunton J, Jones R. Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II. Rapid Communications in Mass Spectrometry : Rcm. 13: 1650-6. PMID 10440983 DOI: 10.1002/(SICI)1097-0231(19990830)13:16<1650::AID-RCM693>3.0.CO;2-8 |
0.453 |
|
| 1999 |
Holzbaur IE, Harris RC, Bycroft M, Cortes J, Bisang C, Staunton J, Rudd BA, Leadlay PF. Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase. Chemistry & Biology. 6: 189-95. PMID 10099131 DOI: 10.1016/S1074-5521(99)80035-0 |
0.586 |
|
| 1999 |
Gates PJ, Kearney GC, Jones R, Leadlay PF, Staunton J. Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 13: 242-6. PMID 10097401 DOI: 10.1002/(Sici)1097-0231(19990228)13:4<242::Aid-Rcm447>3.0.Co;2-B |
0.514 |
|
| 1998 |
Weissman KJ, Smith CJ, Hanefeld U, Aggarwal R, Bycroft M, Staunton J, Leadlay PF. The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates. Angewandte Chemie (International Ed. in English). 37: 1437-1440. PMID 29710889 DOI: 10.1002/(Sici)1521-3773(19980605)37:10<1437::Aid-Anie1437>3.0.Co;2-7 |
0.575 |
|
| 1998 |
Staunton J, Wilkinson B. Towards engineered polyketides. Expert Opinion On Investigational Drugs. 7: 1369-87. PMID 15992038 DOI: 10.1517/13543784.7.9.1369 |
0.32 |
|
| 1998 |
Pacey MS, Dirlam JP, Geldart RW, Leadlay PF, McArthur HA, McCormick EL, Monday RA, O'Connell TN, Staunton J, Winchester TJ. Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity. The Journal of Antibiotics. 51: 1029-34. PMID 9918396 DOI: 10.7164/Antibiotics.51.1029 |
0.555 |
|
| 1998 |
Weissman KJ, Bycroft M, Cutter AL, Hanefeld U, Frost EJ, Timoney MC, Harris R, Handa S, Roddis M, Staunton J, Leadlay PF. Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase. Chemistry & Biology. 5: 743-54. PMID 9862800 DOI: 10.1016/S1074-5521(98)90666-4 |
0.592 |
|
| 1998 |
Rowe CJ, Cortés J, Gaisser S, Staunton J, Leadlay PF. Construction of new vectors for high-level expression in actinomycetes. Gene. 216: 215-23. PMID 9714812 DOI: 10.1016/S0378-1119(98)00327-8 |
0.55 |
|
| 1998 |
Böhm I, Holzbaur IE, Hanefeld U, Cortés J, Staunton J, Leadlay PF. Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension. Chemistry & Biology. 5: 407-12. PMID 9710562 DOI: 10.1016/S1074-5521(98)90157-0 |
0.795 |
|
| 1998 |
Weissman KJ, Bycroft M, Staunton J, Leadlay PF. Origin of starter units for erythromycin biosynthesis. Biochemistry. 37: 11012-7. PMID 9692995 DOI: 10.1021/Bi9806246 |
0.605 |
|
| 1998 |
Staunton J. Combinatorial biosynthesis of erythromycin and complex polyketides. Current Opinion in Chemical Biology. 2: 339-45. PMID 9691072 DOI: 10.1016/S1367-5931(98)80007-0 |
0.353 |
|
| 1998 |
Khaw LE, Böhm GA, Metcalfe S, Staunton J, Leadlay PF. Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase. Journal of Bacteriology. 180: 809-14. PMID 9473033 DOI: 10.1128/Jb.180.4.809-814.1998 |
0.552 |
|
| 1998 |
Marsden AF, Wilkinson B, Cortés J, Dunster NJ, Staunton J, Leadlay PF. Engineering broader specificity into an antibiotic-producing polyketide synthase. Science (New York, N.Y.). 279: 199-202. PMID 9422686 DOI: 10.1126/Science.279.5348.199 |
0.582 |
|
| 1998 |
Sheldrake PW, Suckling KE, Woodhouse RN, Murtagh AJ, Herbert RB, Barker AC, Staunton J, Battersby AR. Biosynthesis. Part 30.1 Colchicine: Studies on the ring expansion step focusing on the fate of the hydrogens at C-4 of autumnaline Journal of the Chemical Society - Perkin Transactions 1. 3003-3009. DOI: 10.1039/A803853H |
0.321 |
|
| 1998 |
Harris RC, Cutter AL, Weissman KJ, Hanefeld U, Timoney MC, Staunton J. Enantiospecific Synthesis of Analogues of the Diketide Intermediate of the Erythromycin Polyketide Synthase (PKS) Journal of Chemical Research - Part S. 283. DOI: 10.1039/A800584B |
0.365 |
|
| 1998 |
Wilkinson AL, Hanefeld U, Wilkinson B, Leadlay PF, Staunton J. Enantiospecific synthesis of tetrasubstituted δ-lactones Tetrahedron Letters. 39: 9827-9830. DOI: 10.1016/S0040-4039(98)02243-6 |
0.545 |
|
| 1998 |
Weissman KJ, Smith CJ, Hanefeld U, Aggarwal R, Bycroft M, Staunton J, Leadlay PF. The thioesterase of the erythromycin-producing polyketide synthase: Influence of acyl chain structure on the mode of release of substrate analogues from the acyl enzyme intermediates Angewandte Chemie - International Edition. 37: 1437-1440. DOI: 10.1002/(SICI)1521-3773(19980605)37:10<1437::AID-ANIE1437>3.0.CO;2-7 |
0.488 |
|
| 1998 |
Weissman K, Smith C, Hanefeld U, Aggarwal R, Bycroft M, Staunton J, Leadlay P. Die Thioesterase der Polyketid-Synthase von Erythromycin: Einfluß der Acylkettenstruktur auf den Abkopplungsmechanismus der Substratanaloga von der Acyl-Enzym-Zwischenstufe Angewandte Chemie. 110: 1503-1506. DOI: 10.1002/(Sici)1521-3757(19980518)110:10<1503::Aid-Ange1503>3.0.Co;2-4 |
0.522 |
|
| 1997 |
Staunton J, Wilkinson B. Biosynthesis of Erythromycin and Rapamycin. Chemical Reviews. 97: 2611-2630. PMID 11851474 DOI: 10.1021/Cr9600316 |
0.617 |
|
| 1997 |
Weissman KJ, Timoney M, Bycroft M, Grice P, Hanefeld U, Staunton J, Leadlay PF. The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase. Biochemistry. 36: 13849-55. PMID 9374862 DOI: 10.1021/Bi971566B |
0.592 |
|
| 1997 |
König A, Schwecke T, Molnar I, Böhm GA, Lowden PA, Staunton J, Leadlay PF. The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus. European Journal of Biochemistry / Febs. 247: 526-34. PMID 9266694 DOI: 10.1111/J.1432-1033.1997.00526.X |
0.581 |
|
| 1997 |
Galloway IS, Rowe CJ, Cortes J, Staunton J, Leadlay PF. A system for the enhanced expression of genes in saccharopolyspora erythraea and its use in the production of novel polyketides Faseb Journal. 11: A1144. |
0.461 |
|
| 1996 |
Oliynyk M, Brown MJ, Cortés J, Staunton J, Leadlay PF. A hybrid modular polyketide synthase obtained by domain swapping. Chemistry & Biology. 3: 833-9. PMID 8939702 DOI: 10.1016/S1074-5521(96)90069-1 |
0.58 |
|
| 1996 |
Aparicio JF, Molnár I, Schwecke T, König A, Haydock SF, Khaw LE, Staunton J, Leadlay PF. Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase. Gene. 169: 9-16. PMID 8635756 DOI: 10.1016/0378-1119(95)00800-4 |
0.562 |
|
| 1996 |
Molnár I, Aparicio JF, Haydock SF, Khaw LE, Schwecke T, König A, Staunton J, Leadlay PF. Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase. Gene. 169: 1-7. PMID 8635730 DOI: 10.1016/0378-1119(95)00799-7 |
0.542 |
|
| 1996 |
Staunton J, Caffrey P, Aparicio JF, Roberts GA, Bethell SS, Leadlay PF. Evidence for a double-helical structure for modular polyketide synthases. Nature Structural Biology. 3: 188-92. PMID 8564546 DOI: 10.1038/Nsb0296-188 |
0.561 |
|
| 1996 |
Less SL, Leadlay PF, Dutton CJ, Staunton J. Biosynthesis of tetronasin: Part 7. Preparation of structural analogues of the tetraketide biosynthetic precursor to tetronasin Tetrahedron Letters. 37: 3519-3520. DOI: 10.1016/0040-4039(96)00601-6 |
0.544 |
|
| 1996 |
Less SL, Handa S, Millburn K, Leadlay PF, Dutton CJ, Staunton J. Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin Tetrahedron Letters. 37: 3515-3518. DOI: 10.1016/0040-4039(96)00600-4 |
0.551 |
|
| 1996 |
Less SL, Handa S, Leadlay PF, Dutton CJ, Staunton J. Biosynthesis of tetronasin: Part 5. Novel fluorinated and non-fluorinated analogues of tetronasin via intact incorporation of di-, tri- and tetraketide analogue precursors Tetrahedron Letters. 37: 3511-3514. DOI: 10.1016/0040-4039(96)00599-0 |
0.537 |
|
| 1996 |
Lowden PAS, Böhm GA, Staunton J, Leadlay PF. The nature of the starter unit for the rapamycin polyketide synthase Angewandte Chemie (International Edition in English). 35: 2249-2251. DOI: 10.1002/Anie.199622491 |
0.512 |
|
| 1996 |
Lowden PAS, Böhm GA, Staunton J, Leadlay PF. Die Startereinheit der Rapamycin-Polyketid-Synthase Angewandte Chemie. 108: 2395-2397. DOI: 10.1002/Ange.19961081927 |
0.515 |
|
| 1995 |
Wiesmann KE, Cortés J, Brown MJ, Cutter AL, Staunton J, Leadlay PF. Polyketide synthesis in vitro on a modular polyketide synthase. Chemistry & Biology. 2: 583-9. PMID 9383462 DOI: 10.1016/1074-5521(95)90122-1 |
0.603 |
|
| 1995 |
Cortes J, Wiesmann KE, Roberts GA, Brown MJ, Staunton J, Leadlay PF. Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Science (New York, N.Y.). 268: 1487-9. PMID 7770773 DOI: 10.1126/Science.7770773 |
0.566 |
|
| 1995 |
Haydock SF, Aparicio JF, Molnár I, Schwecke T, Khaw LE, König A, Marsden AF, Galloway IS, Staunton J, Leadlay PF. Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. Febs Letters. 374: 246-8. PMID 7589545 DOI: 10.1016/0014-5793(95)01119-Y |
0.572 |
|
| 1995 |
Aggarwal R, Caffrey P, Leadlay PF, Smith CJ, Staunton J. The thioesterase of the erythromycin-producing polyketide synthase: Mechanistic studies in vitro to investigate its mode of action and substrate specificity Journal of the Chemical Society, Chemical Communications. 1519-1520. DOI: 10.1039/C39950001519 |
0.534 |
|
| 1995 |
Brown MJB, Cortes J, Cutter AL, Leadlay PF, Staunton J. A mutant generated by expression of an engineered DEBS 1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coelicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate as starter acid Journal of the Chemical Society, Chemical Communications. 1517-1518. DOI: 10.1039/C39950001517 |
0.575 |
|
| 1995 |
Hill AM, Staunton J. The pentaketide hydroxyacyl intermediate in aspyrone biosynthesis in Aspergillus melieus is shown to be the (S)-enantiomer using deuterium-labelled precursors and 2H NMR Journal of the Chemical Society, Chemical Communications. 861-862. DOI: 10.1039/C39950000861 |
0.321 |
|
| 1995 |
Hill AM, Jacobs A, Staunton J. Investigation of the stereochemistry of the tri- and tetra-ketide hydroxyacyl intermediates in the biosynthesis of the polyketide aspyrone in Aspergillus malleus using deuterium labelling and deuterium NMR spectroscopy Journal of the Chemical Society, Chemical Communications. 859-860. DOI: 10.1039/C39950000859 |
0.331 |
|
| 1994 |
Marsden AFA, Caffrey P, Aparicio JF, Loughran MS, Staunton J, Leadlay PF. Stereospecific acyl transfers on the erythromycin-producing polyketide synthase Science. 263: 378-380. PMID 8278811 DOI: 10.1126/Science.8278811 |
0.585 |
|
| 1994 |
Dutton CJ, Hooper AM, Leadlay PF, Staunton J. Avermectin biosynthesis. Intact incorporation of a diketide chain-assembly intermediate into the polyketide macrocyclic ring Tetrahedron Letters. 35: 327-330. DOI: 10.1016/S0040-4039(00)76544-0 |
0.565 |
|
| 1994 |
Boons G, Lennon IC, Ley SV, Owen ES, Staunton J, Wadsworth DJ. Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603) Tetrahedron Letters. 35: 323-326. DOI: 10.1016/S0040-4039(00)76543-9 |
0.332 |
|
| 1994 |
Hailes HC, Handa S, Leadlay PF, Lennon IC, Ley SV, Staunton J. Biosynthesis of tetronasin: Part 3 preparation of deuterium labelled tri- and tetraketides as putative biosynthetic precursors of tetronasin Tetrahedron Letters. 35: 315-318. DOI: 10.1016/S0040-4039(00)76541-5 |
0.476 |
|
| 1994 |
Hailes HC, Handa S, Leadlay PF, Lennon IC, Ley SV, Staunton J. Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase Tetrahedron Letters. 35: 311-314. DOI: 10.1016/S0040-4039(00)76540-3 |
0.513 |
|
| 1994 |
Hailes HC, Jackson CM, Leadlay PF, Ley SV, Staunton J. Biosynthesis of tetronasin: Part 1 introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase Tetrahedron Letters. 35: 307-310. DOI: 10.1016/S0040-4039(00)76539-7 |
0.539 |
|
| 1993 |
Roberts GA, Staunton J, Leadlay PF. Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase. European Journal of Biochemistry / Febs. 214: 305-11. PMID 8508800 DOI: 10.1111/J.1432-1033.1993.Tb17925.X |
0.593 |
|
| 1993 |
Roberts GA, Staunton J, Leadlay PF. 6-Deoxyerythronolide B synthase 3 from Saccharopolyspora erythraea: over-expression in Escherichia coli, purification and characterisation. Biochemical Society Transactions. 21: 32S. PMID 8449313 DOI: 10.1042/Bst021032S |
0.507 |
|
| 1993 |
Cooper HN, Cortes J, Bevitt DJ, Leadlay PF, Staunton J. Analysis of a gene cluster from S. longisporoflavus potentially involved in tetronasin biosynthesis Biochemical Society Transactions. 21: 31S. PMID 8449312 DOI: 10.1042/Bst021031S |
0.512 |
|
| 1993 |
Bevitt DJ, Staunton J, Leadlay PF. Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase Biochemical Society Transactions. 21: 30S. PMID 8449310 DOI: 10.1042/Bst021030S |
0.758 |
|
| 1993 |
Leadlay PF, Staunton J, Aparicio JF, Bevitt DJ, Caffrey P, Cortes J, Marsden A, Roberts GA. The erythromycin-producing polyketide synthase. Biochemical Society Transactions. 21: 218-22. PMID 8449298 DOI: 10.1042/Bst0210218 |
0.555 |
|
| 1993 |
Morris SA, Revill WP, Staunton J, Leadlay PF. Purification and separation of holo- and apo-forms of Saccharopolyspora erythraea acyl-carrier protein released from recombinant Escherichia coli by freezing and thawing. The Biochemical Journal. 294: 521-7. PMID 8373367 DOI: 10.1042/Bj2940521 |
0.761 |
|
| 1992 |
Caffrey P, Bevitt DJ, Staunton J, Leadlay PF. Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea Febs Letters. 304: 225-228. PMID 1618327 DOI: 10.1016/0014-5793(92)80624-P |
0.52 |
|
| 1991 |
Caffrey P, Green B, Packman LC, Rawlings BJ, Staunton J, Leadlay PF. An acyl-carrier-protein - thioesterase domain from the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-level production, purification and characterisation in Escherichia coli European Journal of Biochemistry. 195: 823-830. PMID 1999200 DOI: 10.1111/J.1432-1033.1991.Tb15771.X |
0.573 |
|
| 1991 |
Jacobs A, Staunton J, Sutkowski AC. Aspyrone biosynthesis in Aspergillus melleus: identification of the intermediates formed on the polyketide synthase (PKS) in the first chain extension cycle leading to crotonate Journal of the Chemical Society, Chemical Communications. 1991: 1113-1114. DOI: 10.1039/C39910001113 |
0.363 |
|
| 1991 |
Staunton J, Sutkowski AC. Biosynthesis of aspyrone, a metabolite of Aspergillus melleus: advanced precursor studies to identify the product of the polyketide synthase Journal of the Chemical Society, Chemical Communications. 1108-1110. DOI: 10.1039/C39910001108 |
0.317 |
|
| 1991 |
Bridges AM, Leadlay PF, Revill WP, Staunton J. Use of electrospray mass spectrometry in enzymic studies on acyl carrier protein implicated in fatty acid biosynthesis in Saccharopolyspora erythraea Journal of the Chemical Society, Chemical Communications. 778-779. DOI: 10.1039/C39910000778 |
0.548 |
|
| 1991 |
Bridges AM, Leadlay PF, Revill WP, Staunton J. Use of electrospray mass spectrometry to assay chemical reactivity of an acyl carrier protein involved in fatty acid biosynthesis in Saccharopolyspora erythraea Journal of the Chemical Society, Chemical Communications. 776-777. DOI: 10.1039/C39910000776 |
0.53 |
|
| 1990 |
Battersby R, Scott A, Staunton J. Studies of enzyme-mediated reactions. Part 161. Stereochemical course of the formation of 5-hydroxytryptamine (serotonin) by decarboxylation of (2)-5-hydroxytryptophan with the aromatic L-amino acid decarboxylase (E.C. 4.1.1.28) from hog kidney Tetrahedron. 46: 4685-4696. DOI: 10.1016/S0040-4020(01)85589-7 |
0.333 |
|
| 1988 |
Demetriadou AK, Laue ED, Staunton J. Biosynthesis of palitantin, a polyketide metabolite of Penicillium brefeldianum: 13C n.m.r. assignment and incorporation of 13C-, 2H-, and 18O2-labelled acetates Journal of the Chemical Society-Perkin Transactions 1. 773-778. DOI: 10.1039/P19880000773 |
0.329 |
|
| 1988 |
Demetriadou AK, Laue ED, Staunton J. A study of biosynthesis of the polyketide polivione in Penicillium frequentans using 13C-, 2H-, and 18O-labelled precursors Journal of the Chemical Society-Perkin Transactions 1. 769-772. DOI: 10.1039/P19880000769 |
0.326 |
|
| 1988 |
Lewis CN, Staunton J, Sunter DC. Biosynthesis of canescin, a metabolite of Aspergillus malignus: incorporation of methionine, acetate, succinate, and isocoumarin precursors, labelled with deuterium and carbon-13 Journal of the Chemical Society-Perkin Transactions 1. 747-754. DOI: 10.1039/P19880000747 |
0.339 |
|
| 1987 |
Abell C, Sutkowski AC, Staunton J. Studies on the biosynthesis of hydroxymellein using 17O n.m.r. and 2H n.m.r. spectroscopy to determine the origin of the C-4 hydroxy group Journal of the Chemical Society, Chemical Communications. 586-587. DOI: 10.1039/C39870000586 |
0.489 |
|
| 1987 |
REGAN AC, STAUNTON J. ChemInform Abstract: Asymmetric Synthesis of (+)-Citrinin Using an ortho-Toluate Carbanion Generated by a Chiral Base. Cheminform. 18. DOI: 10.1002/CHIN.198739169 |
0.509 |
|
| 1986 |
Barber JA, Staunton J, Wilkinson MR. A diastereoselective synthesis of the polyketide antibiotic citrinin using toluate anion chemistry Journal of the Chemical Society-Perkin Transactions 1. 2101-2109. DOI: 10.1039/P19860002101 |
0.603 |
|
| 1986 |
Garson MJ, Jenkins SM, Staunton J, Chaloner PA. Isolation of some new 3,6-dialkyl-1,4-dihydroxypiperazine-2,5-diones from Aspergillus terreus Journal of the Chemical Society-Perkin Transactions 1. 17: 901-903. DOI: 10.1039/P19860000901 |
0.323 |
|
| 1986 |
Abell C, Bush BD, Staunton J. Biomimetic syntheses of the polyketide fungal metabolites alternariol and rubrofusarin: models for cyclisation reactions catalysed by polyketide synthase enzymes Journal of the Chemical Society, Chemical Communications. 15-17. DOI: 10.1039/C39860000015 |
0.546 |
|
| 1986 |
Garson MJ, Jenkins SM, Staunton J, Chaloner PA. Isolation of some new 3,6-dialkyl-1,4-dihydroxypiperazine-2,5-diones from Aspergillus terreus Journal of the Chemical Society, Perkin Transactions 1. 901-903. |
0.456 |
|
| 1985 |
Demetriadou AK, Laue ED, Staunton J. The biosynthesis of the polyketide metabolite palitantin from deuterium and oxygen labelled acetates in Penicillium brefeldianum Journal of the Chemical Society, Chemical Communications. 1125-1127. DOI: 10.1039/C39850001125 |
0.324 |
|
| 1984 |
Leeper FJ, Staunton J. The biosynthesis of rubrofusarin, a polyketide naphthopyrone from Fusarium culmorum: 13C n.m.r. assignments and incorporation of 13C- and 2H-labelled acetates Journal of the Chemical Society-Perkin Transactions 1. 2919-2925. DOI: 10.1039/P19840002919 |
0.314 |
|
| 1984 |
Brereton RG, Garson MJ, Staunton J. Biosynthesis of fungal metabolites: asperlactone and its relationship to other metabolites of Aspergillus melleus Journal of the Chemical Society-Perkin Transactions 1. 15: 1027-1033. DOI: 10.1039/P19840001027 |
0.346 |
|
| 1984 |
Garson MJ, Staunton J, Jones PG. New polyketide metabolites from Aspergillus melleus: structural and stereochemical studies Journal of the Chemical Society-Perkin Transactions 1. 15: 1021-1026. DOI: 10.1039/P19840001021 |
0.332 |
|
| 1984 |
Copeland RJ, Hill RA, Hinchcliffe DJ, Staunton J. Biosynthesis of aspyrone, a metabolite of Aspergillus malleus. Incorporation studies with 14C- and 3H-labelled acetates and malonate Journal of the Chemical Society-Perkin Transactions 1. 1013-1019. DOI: 10.1039/P19840001013 |
0.36 |
|
| 1984 |
Abell C, Staunton J. Biosynthesis of 6-methylsalicylic acid; the combined use of mono- and tri-duteriated acetate precursors to investigate the degree of stereocontrol in the aromatisation sequence Journal of the Chemical Society, Chemical Communications. 1005-1007. DOI: 10.1039/C39840001005 |
0.514 |
|
| 1983 |
Abell C, Doddrell DM, Garson MJ, Laue ED, Staunton J. Biosynthesis of the polyketide mellein from CD3CO2H and 13CD3CO2H in Aspergillus melleus: detection of deuterium by 2H n.m.r. and edited 13C n.m.r. spectra Journal of the Chemical Society, Chemical Communications. 694-696. DOI: 10.1039/C39830000694 |
0.483 |
|
| 1983 |
REGAN AC, STAUNTON J. ChemInform Abstract: ASYMMETRIC SYNTHESIS OF MELLEIN METHYL ETHER: USE OF ORTHO-TOLUATE CARBANIONS GENERATED BY CHIRAL BASES Chemischer Informationsdienst. 14. DOI: 10.1002/Chin.198347190 |
0.568 |
|
| 1982 |
Battersby AR, Staunton J, Tippett J. Studies of enzyme-mediated reactions. Part 15. Stereochemical course of the formation of γ-aminobutyric acid (GABA) by decarboxylation of (2S)-glutamic acid with glutamate decarboxylase from Escherichia coli Journal of the Chemical Society-Perkin Transactions 1. 13: 455-459. DOI: 10.1039/P19820000455 |
0.324 |
|
| 1982 |
Battersby AR, Murphy R, Staunton J. Studies of enzyme-mediated reactions. Part 14. Stereochemical course of the formation of cadaverine by decarboxylation of (2S)-lysine with lysine decarboxylase (E.C. 4.1.1.18) from Bacillus cadaveris Journal of the Chemical Society-Perkin Transactions 1. 13: 449-453. DOI: 10.1039/P19820000449 |
0.303 |
|
| 1982 |
Abell C, Garson MJ, Leeper FJ, Staunton J. Biosynthesis of the fungal metabolites alternariol, mellein, rubrofusarin, and 6-methylsalicylic acid from CD3CO2H Journal of the Chemical Society, Chemical Communications. 1011-1013. DOI: 10.1039/C39820001011 |
0.505 |
|
| 1981 |
Barber J, Garson MJ, Staunton J. The biosynthesis of fungal metabolites: Sclerin, a plant growth hormone from Sclerotinia sclerotiorum Journal of the Chemical Society, Perkin Transactions 1. 2584-2593. DOI: 10.1039/P19810002584 |
0.696 |
|
| 1981 |
Barber J, Carter RH, Garson MJ, Staunton J. The biosynthesis of citrinin by Penicillium citrinum Journal of the Chemical Society, Perkin Transactions 1. 2577-2583. DOI: 10.1039/P19810002577 |
0.705 |
|
| 1981 |
Hill RA, Carter RH, Staunton J. Biosynthesis of fungal metabolites. Terrein, a metabolite of Aspergillus terreus Thom Journal of the Chemical Society-Perkin Transactions 1. 12: 2570-2576. DOI: 10.1039/P19810002570 |
0.316 |
|
| 1981 |
Battersby AR, Jones RCF, Minta A, Ottridge AP, Staunton J. Biosynthesis. Part 25. Proof that hasubanonine and protostephanine are biosynthesised from the 1-benzylisoquinoline system Journal of the Chemical Society-Perkin Transactions 1. 12: 2030-2039. DOI: 10.1039/P19810002030 |
0.308 |
|
| 1981 |
Battersby AR, Jones RCF, Kazlauskas R, Thornber CW, Ruchirawat S, Staunton J. Biosynthesis. Part 24. Speculative incorporation experiments with 1-benzylisoquinolines and a logical approach via C6–C2 and C6–C3 precursors to the biosynthesis of hasubanonine and protostephanine Journal of the Chemical Society-Perkin Transactions 1. 12: 2016-2029. DOI: 10.1039/P19810002016 |
0.323 |
|
| 1981 |
Battersby AR, Jones RCF, Kazlauskas R, Ottridge AP, Poupat C, Staunton J. Biosynthesis. Part 23. Degradative studies on the alkaloids hasubanonine and protostephanine from Stephania japonica Journal of the Chemical Society-Perkin Transactions 1. 12: 2010-2015. DOI: 10.1039/P19810002010 |
0.336 |
|
| 1981 |
Battersby AR, Bhatnagar AK, Hackett P, Thornber CW, Staunton J. Synthesis along biosynthetic pathways. Part 2. Synthesis of protostephanine Journal of the Chemical Society-Perkin Transactions 1. 12: 2002-2009. DOI: 10.1039/P19810002002 |
0.302 |
|
| 1981 |
Barber J, Staunton J. The total synthesis of some deuterium labelled pentaketide derivatives of orsellinic acid Journal of the Chemical Society-Perkin Transactions 1. 12: 1685-1689. DOI: 10.1039/P19810001685 |
0.605 |
|
| 1981 |
Carter RH, Garson MJ, Hill RA, Staunton J, Sunter DC. The synthesis of indan-1-ones and isocoumarins Journal of the Chemical Society-Perkin Transactions 1. 12: 471-479. DOI: 10.1039/P19810000471 |
0.314 |
|
| 1981 |
Abell C, Staunton J. The use of 2H n.m.r. spectroscopy and β-isotopic shifts in the 13C n.m.r. spectrum to measure deuterium retention in the biosynthesis of the polyketide 6-methylsalicylic acid Journal of the Chemical Society, Chemical Communications. 856-858. DOI: 10.1039/C39810000856 |
0.495 |
|
| 1981 |
Garson MJ, Staunton J. The biosynthesis of asperlactone: Incorporation studies with [2-<sup>13</sup>C,2-<sup>2</sup>H<inf>3</inf>]acetate Journal of the Chemical Society - Series Chemical Communications. 708-710. DOI: 10.1039/C39810000708 |
0.525 |
|
| 1981 |
Brereton RG, Garson MJ, Staunton J. The application of adjustable-parameter sine bell apodization to carbon-13 NMR spectra Journal of Magnetic Resonance (1969). 43: 224-233. DOI: 10.1016/0022-2364(81)90033-0 |
0.523 |
|
| 1981 |
BARBER J, GARSON MJ, STAUNTON J. ChemInform Abstract: THE BIOSYNTHESIS OF FUNGAL METABOLITES: SCLERIN, A PLANT GROWTH HORMONE FROM SCLEROTINIA SCLEROTIORUM Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198151365 |
0.633 |
|
| 1980 |
Battersby AR, Chrystal EJ, Staunton J. Studies of enzyme-mediated reactions. Part 12. Stereochemical course of the decarboxylation of (2S)-tyrosine to tyramine by microbial, mammalian, and plant systems. Journal of the Chemical Society. Perkin Transactions 1. 1: 31-42. PMID 6766946 DOI: 10.1039/P19800000031 |
0.315 |
|
| 1980 |
Barber J, Staunton J. New insights into polyketide metabolism; the use of protium as a tracer in the biosynthesis of citrinin by Penicillium citrinum Journal of the Chemical Society-Perkin Transactions 1. 2244-2248. DOI: 10.1039/P19800002244 |
0.577 |
|
| 1980 |
Barber J, Staunton J. Citrinin biosynthesis in P. citrinum: incorporation of a deuterium-labelled advanced precursor in the presence of a specific inhibitor of an early step Journal of the Chemical Society, Chemical Communications. 1163-1164. DOI: 10.1039/C39800001163 |
0.598 |
|
| 1980 |
Barber J, Staunton J. Biosynthesis of citrinin in Penicillium citrinum: advanced precursor studies using 2H nuclear magnetic resonance spectroscopy Journal of the Chemical Society, Chemical Communications. 552-554. DOI: 10.1039/C39800000552 |
0.576 |
|
| 1980 |
MURPHY JA, STAUNTON J. ChemInform Abstract: NOVEL SYNTHESIS OF PRETETRAMID Chemischer Informationsdienst. 11. DOI: 10.1002/Chin.198017196 |
0.486 |
|
| 1980 |
MURPHY JA, STAUNTON J. ChemInform Abstract: A NOVEL BASE-INDUCED CYCLIZATION TO PRODUCE AN ARYL RING Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198017189 |
0.423 |
|
| 1979 |
Battersby AR, Buckley DG, Staunton J, Williams PJ. Studies of enzyme-mediated reactions. Part 10. Stereochemical course of the dehydrogenation of stereospecifically labelled 1-amino-heptanes by the amine oxidase from rat liver mitochondria (E.C. 1.4.3.4). Journal of the Chemical Society. Perkin Transactions 1. 10: 2550-8. PMID 575782 DOI: 10.1039/P19790002550 |
0.323 |
|
| 1979 |
Battersby AR, Staunton J, Summers MC, Southgate R. Studies of enzyme-mediated reactions. Part 9. Stereochemistry of oxidative ring cleavage adjacent to nitrogen during the biosynthesis of chelidonine Journal of the Chemical Society-Perkin Transactions 1. 45-52. DOI: 10.1039/P19790000045 |
0.334 |
|
| 1979 |
Garson MJ, Staunton J. Some new N.M.R. methods for tracing the fate of hydrogen in biosynthesis Chemical Society Reviews. 8: 539-561. DOI: 10.1039/CS9790800539 |
0.463 |
|
| 1979 |
Murphy JA, Staunton J. Novel synthesis of pretetramid Journal of the Chemical Society, Chemical Communications. 1166-1167. DOI: 10.1039/C39790001166 |
0.478 |
|
| 1979 |
Murphy JA, Staunton J. A novel base-induced cyclisation to produce an aryl ring Journal of the Chemical Society, Chemical Communications. 1165-1166. DOI: 10.1039/C39790001165 |
0.5 |
|
| 1979 |
Barber J, Staunton J. Protium as a tracer in polyketide biosynthesis: incorporation of 13CH313CO2H into citrinin produced on a medium based on D2O Journal of the Chemical Society, Chemical Communications. 1098-1099. DOI: 10.1039/C39790001098 |
0.578 |
|
| 1979 |
Carter RH, Garson MJ, Staunton J. Biosynthesis of citrinin: Incorporation studies with advanced precursors Journal of the Chemical Society, Chemical Communications. 1097-1098. DOI: 10.1039/C39790001097 |
0.554 |
|
| 1979 |
Evans GE, Leeper FJ, Murphy JA, Staunton J. Triacetic acid lactone as a polyketide synthon: Synthesis of toralactone and polyketide-type anthracene derivatives Journal of the Chemical Society, Chemical Communications. 205-206. DOI: 10.1039/C39790000205 |
0.499 |
|
| 1979 |
EVANS GE, LEEPER FJ, MURPHY JA, STAUNTON J. ChemInform Abstract: TRIACETIC ACID LACTONE AS A POLYKETIDE SYNTHON: SYNTHESIS OF TORALACTONE AND POLYKETIDE-TYPE ANTHRACENE DERIVATIVES Chemischer Informationsdienst. 10. DOI: 10.1002/Chin.197945225 |
0.503 |
|
| 1978 |
Leeper FJ, Staunton J. Biomimetic syntheses of heptaketide metabolites: alternariol and a derivative of rubrofusarin Journal of the Chemical Society, Chemical Communications. 406-407. DOI: 10.1039/C39780000406 |
0.304 |
|
| 1977 |
Garson MJ, Hill RA, Staunton J. Deuterium as a tracer in polyketide biosynthesis: A new method for the detection of chain starter units Journal of the Chemical Society, Chemical Communications. 921-922. DOI: 10.1039/C39770000921 |
0.562 |
|
| 1977 |
Garson MJ, Hill RA, Staunton J. Deuterium as a tracer in polyketide biosynthesis: Incorporation of [2- 13C,2-2H3]acetate into terrein Journal of the Chemical Society, Chemical Communications. 624-626. DOI: 10.1039/C39770000624 |
0.551 |
|
| 1976 |
Battersby AR, McDonald E, Redfern JR, Staunton J, Wightman RH. Biosynthesis of porphyrins and related macrocycles. Part V. Structural integrity of the type III porphyrinogen macrocycle in an active biological system; studies on the aromatisation of protoporphyrinogen-IX. Journal of the Chemical Society. Perkin Transactions 1. 266-73. PMID 942965 DOI: 10.1039/P19760000266 |
0.368 |
|
| 1976 |
Battersby AR, Staunton J, Summers MC. Studies of enzyme-mediated reactions. Part VI. Stereochemical course of the dehydrogenation of stereospecifically labelled benzylamines by the amine oxidase from pea seedlings (E.C. 1.4.3.6.). Journal of the Chemical Society. Perkin Transactions 1. 1052-6. PMID 819449 DOI: 10.1039/P19760001052 |
0.361 |
|
| 1976 |
Garson MJ, Staunton J. Biosynthesis of sclerin, a metabolite of Sclerotinia sclerotiorum: incorporation of [1-13C]- and [1,2-13C2]- acetates Journal of the Chemical Society, Chemical Communications. 928-929. DOI: 10.1039/C39760000928 |
0.571 |
|
| 1975 |
Battersby AR, Staunton J, Wiltshire HR, Bircher BJ, Fuganti C. Studies of enzyme-mediated reactions. Part V. Synthesis of (13S)- and (13R)-[13-3H1]scoulerine from stereospecifically labelled (R)- and (S)-[α3H1]benzyl alcohols; stereochemistry of enzymic reactions at saturated benzylic carbon Journal of the Chemical Society-Perkin Transactions 1. 6: 1162-1171. DOI: 10.1039/P19750001162 |
0.34 |
|
| 1975 |
Battersby AR, Staunton J, Wiltshire HR, Francis RJ, Southgate R. Biosynthesis. Part XXII. The origin of chelidonine and of other alkaloids derived from the tetrahydroprotoberberine skeleton Journal of the Chemical Society-Perkin Transactions 1. 1147-1156. DOI: 10.1039/P19750001147 |
0.335 |
|
| 1975 |
Battersby AR, Francis RJ, Hirst M, Ruveda EA, Staunton J. Biosynthesis. Part XXI. Investigations on the biosynthesis of stylopine in Chelidonium majus Journal of the Chemical Society-Perkin Transactions 1. 1140-1147. DOI: 10.1039/P19750001140 |
0.317 |
|
| 1975 |
Hill RA, Carter RH, Staunton J. Biosynthesis of terrein, a metabolite of Aspergillus terreus Thom Journal of the Chemical Society, Chemical Communications. 380-381. DOI: 10.1039/C39750000380 |
0.302 |
|
| 1974 |
Battersby AR, Staunton J, Summers MC. Stereochemistry of dehydrogenation catalysed by the amine oxidase from pea seedlings (E.C.1.4.3.5.) Journal of the Chemical Society, Chemical Communications. 548-549. DOI: 10.1039/C39740000548 |
0.306 |
|
| 1973 |
Battersby AR, Kelsey JE, Staunton J, Suckling KE. Studies of enzyme-mediated reactions. 3. Stereoselective labelling at C-2 of tyramine: stereochemistry of hydroxylation at saturated carbon. Journal of the Chemical Society. Perkin Transactions 1. 15: 1609-15. PMID 4796394 DOI: 10.1039/P19730001609 |
0.335 |
|
| 1972 |
Wightman RH, Staunton J, Battersby AR, Hanson KR. Studies of enzyme-mediated reactions. I. Syntheses of deuterium- or tritium-labelled (3S)-and (3R)-phenylalanines: stereochemical course of the elimination catalysed by L-phenylalanine ammonia-lyase. Journal of the Chemical Society. Perkin Transactions 1. 18: 2355-64. PMID 4674457 DOI: 10.1039/P19720002355 |
0.329 |
|
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