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Steven A. Benner - Publications

Affiliations: 
Chemistry University of Florida, Gainesville, Gainesville, FL, United States 
Area:
"synthetic biology"
Website:
http://www.ffame.org/sbenner.php
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Year Citation  Score
2022 Jerome CA, Hoshika S, Bradley KM, Benner SA, Biondi E. In vitro evolution of ribonucleases from expanded genetic alphabets. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208261119. PMID 36279447 DOI: 10.1073/pnas.2208261119  0.305
2020 Ganguly A, Weissman BP, Giese TJ, Li NS, Hoshika S, Rao S, Benner SA, Piccirilli JA, York DM. Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme. Nature Chemistry. PMID 31959957 DOI: 10.1038/S41557-019-0391-X  0.576
2019 Zumrut H, Yang Z, Williams N, Arizala JDR, Batool S, Benner S, Mallikaratchy P. Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε. Biochemistry. PMID 31880917 DOI: 10.1021/Acs.Biochem.9B00919  0.325
2019 Benner SA, Kim HJ, Biondi E. Prebiotic Chemistry that Could Not Have Happened. Life (Basel, Switzerland). 9. PMID 31739415 DOI: 10.3390/Life9040084  0.316
2019 Zhang L, Wang S, Yang Z, Hoshika S, Xie S, Li J, Chen X, Wan S, Li L, Benner SA, Tan W. An Aptamer-Nanotrain Assembled from 6-Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells. Angewandte Chemie (International Ed. in English). PMID 31650689 DOI: 10.1002/Anie.201909691  0.652
2019 Hoshika S, Leal NA, Kim MJ, Kim MS, Karalkar NB, Kim HJ, Bates AM, Watkins NE, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia J, Georgiadis MM, ... Benner SA, et al. Hachimoji DNA and RNA: A genetic system with eight building blocks. Science (New York, N.Y.). 363: 884-887. PMID 30792304 DOI: 10.1126/Science.Aat0971  0.801
2019 Laos R, Lampropoulos C, Benner SA. The surprising pairing of 2-aminoimidazo[1,2-a][1,3,5]triazin-4-one, a component of an expanded DNA alphabet. Acta Crystallographica. Section C, Structural Chemistry. 75: 22-28. PMID 30601127 DOI: 10.1107/S2053229618016923  0.339
2018 Ziegler EW, Kim HJ, Benner SA. Molybdenum(VI)-Catalyzed Rearrangement of Prebiotic Carbohydrates in Formamide, a Candidate Prebiotic Solvent. Astrobiology. 18: 1159-1170. PMID 30204496 DOI: 10.1089/Ast.2017.1742  0.315
2018 Hoshika S, Singh I, Switzer C, Molt RW, Leal NA, Kim MJ, Kim MS, Kim HJ, Georgiadis MM, Benner SA. "Skinny" and "Fat" DNA: Two New Double Helices. Journal of the American Chemical Society. PMID 30148365 DOI: 10.1021/Jacs.8B05042  0.674
2018 Karalkar NB, Benner SA. The challenge of synthetic biology. Synthetic Darwinism and the aperiodic crystal structure. Current Opinion in Chemical Biology. 46: 188-195. PMID 30098527 DOI: 10.1016/J.Cbpa.2018.07.008  0.323
2018 Singh I, Laos R, Hoshika S, Benner SA, Georgiadis MM. Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide. Nucleic Acids Research. PMID 29986111 DOI: 10.1093/Nar/Gky552  0.336
2018 Yang Z, Kim HJ, Le JT, McLendon C, Bradley KM, Kim MS, Hutter D, Hoshika S, Yaren O, Benner SA. Nucleoside analogs to manage sequence divergence in nucleic acid amplification and SNP detection. Nucleic Acids Research. PMID 29800323 DOI: 10.1093/Nar/Gky392  0.315
2018 Biondi E, Benner SA. Artificially Expanded Genetic Information Systems for New Aptamer Technologies. Biomedicines. 6. PMID 29747381 DOI: 10.3390/Biomedicines6020053  0.354
2018 Koirala D, Shelke SA, Dupont M, Ruiz S, DasGupta S, Bailey LJ, Benner SA, Piccirilli JA. Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography. Nucleic Acids Research. PMID 29309709 DOI: 10.1093/Nar/Gkx1292  0.781
2018 Benner S. Uniting Natural History with the Molecular Sciences. The Ultimate Multidisciplinarity. Accounts of Chemical Research. 50: 498-502. PMID 28945399 DOI: 10.1021/Acs.Accounts.6B00496  0.303
2017 Kim HJ, Benner SA. A Direct Prebiotic Synthesis of Nicotinamide Nucleotide. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29194806 DOI: 10.1002/Chem.201705394  0.334
2017 Kim HJ, Benner SA. Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases and phosphorylated carbohydrates. Proceedings of the National Academy of Sciences of the United States of America. 114: 11315-11320. PMID 29073050 DOI: 10.1073/Pnas.1710778114  0.348
2017 Singh I, Kim MJ, Molt RW, Hoshika S, Benner SA, Georgiadis MM. Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (X) and 2,4-Diaminopyrimidine (K). Acs Synthetic Biology. PMID 28752992 DOI: 10.1021/Acssynbio.7B00150  0.31
2017 Karalkar NB, Khare K, Molt R, Benner SA. Tautomeric equilibria of iso-guanine and related purine analogs. Nucleosides, Nucleotides & Nucleic Acids. 1-19. PMID 28332916 DOI: 10.1080/15257770.2016.1268694  0.308
2017 Chen F, Zhang Y, Daugherty AB, Yang Z, Shaw R, Dong M, Lutz S, Benner SA. Biological phosphorylation of an Unnatural Base Pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutant. Plos One. 12: e0174163. PMID 28323896 DOI: 10.1371/Journal.Pone.0174163  0.777
2017 Wang X, Hoshika S, Peterson RJ, Kim MJ, Benner SA, Kahn JD. The Biophysics of Artificially Expanded Genetic Information Systems. Thermodynamics of DNA Duplexes Containing Matches and Mismatches Involving 2-Amino-3-nitropyridin-6-one (Z) and Imidazo[1,2-a]-1,3,5-triazin-4(8H)one (P). Acs Synthetic Biology. PMID 28094993 DOI: 10.1021/Acssynbio.6B00224  0.33
2016 Matsuura MF, Winiger CB, Shaw RW, Kim MJ, Kim MS, Daugherty AB, Chen F, Moussatche P, Moses JD, Lutz S, Benner SA. A Single Deoxynucleoside Kinase Variant from Drosophila melanogaster Synthesizes Monophosphates of Nucleosides That Are Components of an Expanded Genetic System. Acs Synthetic Biology. PMID 27935283 DOI: 10.1021/Acssynbio.6B00228  0.786
2016 Matsuura MF, Kim HJ, Takahashi D, Abboud KA, Benner SA. Crystal structures of deprotonated nucleobases from an expanded DNA alphabet. Acta Crystallographica. Section C, Structural Chemistry. 72: 952-959. PMID 27918296 DOI: 10.1107/S2053229616017071  0.352
2016 Biondi E, Lane JD, Das D, Dasgupta S, Piccirilli JA, Hoshika S, Bradley KM, Krantz BA, Benner SA. Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen. Nucleic Acids Research. PMID 27701076 DOI: 10.1093/Nar/Gkw890  0.798
2016 Benner SA, Karalkar NB, Hoshika S, Laos R, Shaw RW, Matsuura M, Fajardo D, Moussatche P. Alternative Watson-Crick Synthetic Genetic Systems. Cold Spring Harbor Perspectives in Biology. PMID 27663774 DOI: 10.1101/Cshperspect.A023770  0.346
2016 Zhang L, Yang Z, Le Trinh T, Teng IT, Wang S, Bradley KM, Hoshika S, Wu Q, Cansiz S, Rowold DJ, McLendon C, Kim MS, Wu Y, Cui C, Liu Y, ... ... Benner SA, et al. Aptamers against Cells Overexpressing Glypican 3 from Expanded Genetic Systems Combined with Cell Engineering and Laboratory Evolution. Angewandte Chemie (International Ed. in English). PMID 27601357 DOI: 10.1002/Anie.201605058  0.638
2016 Yaren O, Bradley KM, Moussatche P, Hoshika S, Yang Z, Zhu S, Karst SM, Benner SA. A Norovirus Detection Architecture Based on Isothermal Amplification and Expanded Genetic Systems. Journal of Virological Methods. PMID 27546345 DOI: 10.1016/J.Jviromet.2016.08.012  0.35
2016 Yaren O, Glushakova LG, Bradley KM, Hoshika S, Benner SA. Standard and AEGIS nicking molecular beacons detect amplicons from the Middle East respiratory syndrome coronavirus. Journal of Virological Methods. 236: 54-61. PMID 27421627 DOI: 10.1016/J.Jviromet.2016.07.008  0.33
2016 Winiger CB, Kim MJ, Hoshika S, Shaw RW, Moses JD, Matsuura MF, Gerloff DL, Benner SA. Polymerase Interactions with Wobble Mismatches in Synthetic Genetic Systems and their Evolutionary Implications. Biochemistry. PMID 27347689 DOI: 10.1021/Acs.Biochem.6B00533  0.378
2016 Karalkar NB, Leal NA, Kim MS, Bradley KM, Benner SA. Synthesis and Enzymology of 2'-Deoxy-7-deazaisoguanosine Triphosphate and Its Complement: A Second Generation Pair in an Artificially Expanded Genetic Information System. Acs Synthetic Biology. PMID 26914388 DOI: 10.1021/Acssynbio.5B00276  0.336
2016 Matsuura MF, Shaw RW, Moses JD, Kim HJ, Kim MJ, Kim MS, Hoshika S, Karalkar N, Benner SA. Assays To Detect the Formation of Triphosphates of Unnatural Nucleotides: Application to Escherichia coli Nucleoside Diphosphate Kinase. Acs Synthetic Biology. PMID 26829203 DOI: 10.1021/Acssynbio.5B00172  0.34
2015 Scharf C, Virgo N, Cleaves HJ, Aono M, Aubert-Kato N, Aydinoglu A, Barahona A, Barge LM, Benner SA, Biehl M, Brasser R, Butch CJ, Chandru K, Cronin L, Danielache S, et al. A Strategy for Origins of Life Research. Astrobiology. 15: 1031-42. PMID 26684503 DOI: 10.1089/Ast.2015.1113  0.617
2015 Glushakova LG, Sharma N, Hoshika S, Bradley AC, Bradley KM, Yang Z, Benner SA. Detecting respiratory viral RNA using expanded genetic alphabets and self-avoiding DNA. Analytical Biochemistry. 489: 62-72. PMID 26299645 DOI: 10.1016/J.Ab.2015.08.015  0.323
2015 Hernandez AR, Shao Y, Hoshika S, Yang Z, Shelke SA, Herrou J, Kim HJ, Kim MJ, Piccirilli JA, Benner SA. A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair. Angewandte Chemie (International Ed. in English). PMID 26223188 DOI: 10.1002/Anie.201504731  0.591
2015 Zhang L, Yang Z, Sefah K, Bradley KM, Hoshika S, Kim MJ, Kim HJ, Zhu G, Jiménez E, Cansiz S, Teng IT, Champanhac C, McLendon C, Liu C, Zhang W, ... ... Benner SA, et al. Evolution of functional six-nucleotide DNA. Journal of the American Chemical Society. 137: 6734-7. PMID 25966323 DOI: 10.1021/Jacs.5B02251  0.675
2015 Georgiadis MM, Singh I, Kellett WF, Hoshika S, Benner SA, Richards NG. Structural basis for a six nucleotide genetic alphabet. Journal of the American Chemical Society. 137: 6947-55. PMID 25961938 DOI: 10.1021/Jacs.5B03482  0.363
2015 Yang Z, McLendon C, Hutter D, Bradley KM, Hoshika S, Frye CB, Benner SA. Helicase-Dependent Isothermal Amplification of DNA and RNA by Using Self-Avoiding Molecular Recognition Systems. Chembiochem : a European Journal of Chemical Biology. 16: 1365-70. PMID 25953623 DOI: 10.1002/Cbic.201500135  0.332
2015 Kim HJ, Benner SA. Prebiotic glycosylation of uracil with electron-donating substituents. Astrobiology. 15: 301-6. PMID 25860300 DOI: 10.1089/Ast.2014.1264  0.308
2015 McLendon C, Opalko FJ, Illangkoon HI, Benner SA. Solubility of polyethers in hydrocarbons at low temperatures. A model for potential genetic backbones on warm titans. Astrobiology. 15: 200-6. PMID 25761113 DOI: 10.1089/ast.2014.1212  0.764
2015 Glushakova LG, Bradley A, Bradley KM, Alto BW, Hoshika S, Hutter D, Sharma N, Yang Z, Kim MJ, Benner SA. High-throughput multiplexed xMAP Luminex array panel for detection of twenty two medically important mosquito-borne arboviruses based on innovations in synthetic biology. Journal of Virological Methods. 214: 60-74. PMID 25680538 DOI: 10.1016/J.Jviromet.2015.01.003  0.311
2015 Leal NA, Kim HJ, Hoshika S, Kim MJ, Carrigan MA, Benner SA. Transcription, reverse transcription, and analysis of RNA containing artificial genetic components. Acs Synthetic Biology. 4: 407-13. PMID 25137127 DOI: 10.1021/Sb500268N  0.364
2015 Benner SA, Kim HJ. The case for a Martian origin for Earth life Proceedings of Spie - the International Society For Optical Engineering. 9606. DOI: 10.1117/12.2192890  0.322
2015 Benner SA, Kim HJ, Merritt KB, Yang Z, McLendon DC, Hoshika S, Hutter D. Next-generation DNA in pathogen detection, surveillance, and CLIA-waivable diagnostics Proceedings of Spie - the International Society For Optical Engineering. 9490. DOI: 10.1117/12.2183481  0.357
2015 Wang X, Sharp KK, Hoshika S, Bellaousov S, Zhang X, Mathews DH, Benner SA, Peterson RJ, Kahn JD. Structure and Thermodynamics of Aegis Nucleotides P and Z in DNA Biophysical Journal. 108: 395a. DOI: 10.1016/J.Bpj.2014.11.2165  0.326
2015 Hernandez AR, Shao Y, Hoshika S, Yang Z, Shelke SA, Herrou J, Kim H, Kim M, Piccirilli JA, Benner SA. Inside Back Cover: A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair (Angew. Chem. Int. Ed. 34/2015) Angewandte Chemie International Edition. 54: 10035-10035. DOI: 10.1002/Anie.201506280  0.561
2015 Hernandez AR, Shao Y, Hoshika S, Yang Z, Shelke SA, Herrou J, Kim H, Kim M, Piccirilli JA, Benner SA. Innenrücktitelbild: A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair (Angew. Chem. 34/2015) Angewandte Chemie. 127: 10173-10173. DOI: 10.1002/Ange.201506280  0.561
2014 Laos R, Thomson JM, Benner SA. DNA polymerases engineered by directed evolution to incorporate non-standard nucleotides. Frontiers in Microbiology. 5: 565. PMID 25400626 DOI: 10.3389/Fmicb.2014.00565  0.382
2014 Merritt KK, Bradley KM, Hutter D, Matsuura MF, Rowold DJ, Benner SA. Autonomous assembly of synthetic oligonucleotides built from an expanded DNA alphabet. Total synthesis of a gene encoding kanamycin resistance. Beilstein Journal of Organic Chemistry. 10: 2348-60. PMID 25383105 DOI: 10.3762/Bjoc.10.245  0.353
2014 Sharma N, Hoshika S, Hutter D, Bradley KM, Benner SA. Recombinase-based isothermal amplification of nucleic acids with self-avoiding molecular recognition systems (SAMRS). Chembiochem : a European Journal of Chemical Biology. 15: 2268-74. PMID 25209570 DOI: 10.1002/Cbic.201402250  0.351
2014 Bradley KM, Benner SA. OligArch: A software tool to allow artificially expanded genetic information systems (AEGIS) to guide the autonomous self-assembly of long DNA constructs from multiple DNA single strands. Beilstein Journal of Organic Chemistry. 10: 1826-33. PMID 25161743 DOI: 10.3762/Bjoc.10.192  0.346
2014 Kim HJ, Leal NA, Hoshika S, Benner SA. Ribonucleosides for an artificially expanded genetic information system. The Journal of Organic Chemistry. 79: 3194-9. PMID 24597611 DOI: 10.1021/Jo402665D  0.361
2014 Sefah K, Yang Z, Bradley KM, Hoshika S, Jiménez E, Zhang L, Zhu G, Shanker S, Yu F, Turek D, Tan W, Benner SA. In vitro selection with artificial expanded genetic information systems. Proceedings of the National Academy of Sciences of the United States of America. 111: 1449-54. PMID 24379378 DOI: 10.1073/Pnas.1311778111  0.685
2013 Laos R, Shaw R, Leal NA, Gaucher E, Benner S. Directed evolution of polymerases to accept nucleotides with nonstandard hydrogen bond patterns. Biochemistry. 52: 5288-94. PMID 23815560 DOI: 10.1021/Bi400558C  0.689
2013 Benner SA, Bains W, Seager S. Models and standards of proof in cross-disciplinary science: the case of arsenic DNA. Astrobiology. 13: 510-3. PMID 23634974 DOI: 10.1089/Ast.2012.0954  0.309
2013 Neveu M, Kim HJ, Benner SA. The "strong" RNA world hypothesis: fifty years old. Astrobiology. 13: 391-403. PMID 23551238 DOI: 10.1089/Ast.2012.0868  0.33
2013 Yang Z, Durante M, Glushakova LG, Sharma N, Leal NA, Bradley KM, Chen F, Benner SA. Conversion strategy using an expanded genetic alphabet to assay nucleic acids. Analytical Chemistry. 85: 4705-12. PMID 23541235 DOI: 10.1021/Ac400422R  0.356
2012 Carrigan MA, Uryasev O, Davis RP, Zhai L, Hurley TD, Benner SA. The natural history of class I primate alcohol dehydrogenases includes gene duplication, gene loss, and gene conversion. Plos One. 7: e41175. PMID 22859968 DOI: 10.1371/Journal.Pone.0041175  0.305
2012 Benner SA, Kim HJ, Carrigan MA. Asphalt, water, and the prebiotic synthesis of ribose, ribonucleosides, and RNA. Accounts of Chemical Research. 45: 2025-34. PMID 22455515 DOI: 10.1021/Ar200332W  0.339
2012 Kim HJ, Chen F, Benner SA. Synthesis and properties of 5-cyano-substituted nucleoside analog with a donor-donor-acceptor hydrogen-bonding pattern. The Journal of Organic Chemistry. 77: 3664-9. PMID 22390337 DOI: 10.1021/Jo300230Z  0.338
2012 Benner SA, Kim HJ, Yang Z. Setting the stage: the history, chemistry, and geobiology behind RNA. Cold Spring Harbor Perspectives in Biology. 4: a003541. PMID 20880988 DOI: 10.1101/087969739.43.1  0.318
2011 Benner SA, Yang Z, Chen F. Synthetic Biology, Tinkering Biology, and Artificial Biology. What are We Learning? Comptes Rendus. Chimie (Print). 14: 372-387. PMID 29983697 DOI: 10.1016/J.Crci.2010.06.013  0.311
2011 Yang Z, Chen F, Alvarado JB, Benner SA. Amplification, mutation, and sequencing of a six-letter synthetic genetic system. Journal of the American Chemical Society. 133: 15105-12. PMID 21842904 DOI: 10.1021/Ja204910N  0.369
2011 Kim HJ, Ricardo A, Illangkoon HI, Kim MJ, Carrigan MA, Frye F, Benner SA. Synthesis of carbohydrates in mineral-guided prebiotic cycles. Journal of the American Chemical Society. 133: 9457-68. PMID 21553892 DOI: 10.1021/Ja201769F  0.774
2011 Chen F, Yang Z, Yan M, Alvarado JB, Wang G, Benner SA. Recognition of an expanded genetic alphabet by type-II restriction endonucleases and their application to analyze polymerase fidelity. Nucleic Acids Research. 39: 3949-61. PMID 21245035 DOI: 10.1093/Nar/Gkq1274  0.388
2010 Hutter D, Kim MJ, Karalkar N, Leal NA, Chen F, Guggenheim E, Visalakshi V, Olejnik J, Gordon S, Benner SA. Labeled nucleoside triphosphates with reversibly terminating aminoalkoxyl groups. Nucleosides, Nucleotides & Nucleic Acids. 29: 879-95. PMID 21128174 DOI: 10.1080/15257770.2010.536191  0.342
2010 Benner SA, Kim HJ, Kim MJ, Ricardo A. Planetary organic chemistry and the origins of biomolecules. Cold Spring Harbor Perspectives in Biology. 2: a003467. PMID 20504964 DOI: 10.1101/Cshperspect.A003467  0.729
2010 Chen F, Gaucher EA, Leal NA, Hutter D, Havemann SA, Govindarajan S, Ortlund EA, Benner SA. Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection. Proceedings of the National Academy of Sciences of the United States of America. 107: 1948-53. PMID 20080675 DOI: 10.1073/Pnas.0908463107  0.803
2010 Yang Z, Chen F, Chamberlin SG, Benner SA. Expanded genetic alphabets in the polymerase chain reaction. Angewandte Chemie (International Ed. in English). 49: 177-80. PMID 19946925 DOI: 10.1002/Anie.200905173  0.339
2010 Benner SA, Ellington AD. "Progenote" or "protogenote"? Science (New York, N.Y.). 248: 943-4. PMID 17745387 DOI: 10.1126/Science.248.4958.943  0.459
2010 Benner SA, Ricardo A, Carrigan MA. Is there a common chemical model for life in the universe? The Nature of Life: Classical and Contemporary Perspectives From Philosophy and Science. 164-185. DOI: 10.1017/CBO9780511730191.016  0.716
2010 BAESCHLIN DK, DAUBE M, BLAETTLER MO, BENNER SA, RICHERT C. ChemInform Abstract: Four-Step Synthesis of a 5′-Deoxy-5′-iodomethylthymidine. Cheminform. 27: no-no. DOI: 10.1002/chin.199625241  0.463
2010 PICCIRILLI JA, KRAUCH T, MACPHERSON LJ, BENNER SA. ChemInform Abstract: A Direct Route to 3-(D-Ribofuranosyl)pyridine Nucleosides. Cheminform. 22: no-no. DOI: 10.1002/chin.199123248  0.458
2009 Fuller CW, Middendorf LR, Benner SA, Church GM, Harris T, Huang X, Jovanovich SB, Nelson JR, Schloss JA, Schwartz DC, Vezenov DV. The challenges of sequencing by synthesis. Nature Biotechnology. 27: 1013-23. PMID 19898456 DOI: 10.1038/Nbt.1585  0.326
2008 Sheng P, Yang Z, Kim Y, Wu Y, Tan W, Benner SA. Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet. Chemical Communications (Cambridge, England). 5128-30. PMID 18956044 DOI: 10.1039/B811159F  0.422
2008 Branton D, Deamer DW, Marziali A, Bayley H, Benner SA, Butler T, Di Ventra M, Garaj S, Hibbs A, Huang X, Jovanovich SB, Krstic PS, Lindsay S, Ling XS, Mastrangelo CH, et al. The potential and challenges of nanopore sequencing. Nature Biotechnology. 26: 1146-53. PMID 18846088 DOI: 10.1038/Nbt.1495  0.36
2008 Johnson RJ, Gaucher EA, Sautin YY, Henderson GN, Angerhofer AJ, Benner SA. The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. Medical Hypotheses. 71: 22-31. PMID 18331782 DOI: 10.1016/J.Mehy.2008.01.017  0.613
2008 Havemann SA, Hoshika S, Hutter D, Benner SA. Incorporation of multiple sequential pseudothymidines by DNA polymerases and their impact on DNA duplex structure. Nucleosides, Nucleotides & Nucleic Acids. 27: 261-78. PMID 18260010 DOI: 10.1080/15257770701853679  0.792
2008 Kim HJ, Kim MJ, Karalkar N, Hutter D, Benner SA. Synthesis of pyrophosphates for in vitro selection of catalytic RNA molecules. Nucleosides, Nucleotides & Nucleic Acids. 27: 43-56. PMID 18188769 DOI: 10.1080/15257770701571867  0.338
2008 Sassi SO, Benner SA. The resurrection of ribonucleases from mammals: from ecology to medicine Ancestral Sequence Reconstruction. DOI: 10.1093/acprof:oso/9780199299188.003.0018  0.7
2007 Yang Z, Sismour AM, Sheng P, Puskar NL, Benner SA. Enzymatic incorporation of a third nucleobase pair. Nucleic Acids Research. 35: 4238-49. PMID 17576683 DOI: 10.1093/Nar/Gkm395  0.789
2007 Yang Z, Sismour AM, Benner SA. Nucleoside alpha-thiotriphosphates, polymerases and the exonuclease III analysis of oligonucleotides containing phosphorothioate linkages. Nucleic Acids Research. 35: 3118-27. PMID 17452363 DOI: 10.1093/Nar/Gkm168  0.794
2007 Sassi SO, Braun EL, Benner SA. The evolution of seminal ribonuclease: pseudogene reactivation or multiple gene inactivation events? Molecular Biology and Evolution. 24: 1012-24. PMID 17267422 DOI: 10.1093/Molbev/Msm020  0.749
2007 Benner SA, Sassi SO, Gaucher EA. Molecular paleoscience: systems biology from the past. Advances in Enzymology and Related Areas of Molecular Biology. 75: 1-132, xi. PMID 17124866 DOI: 10.1002/9780471224464.Ch1  0.79
2007 Benner SA, Glasfeld A, Piccirilli JA. Stereospecificity in Enzymology: Its Place in Evolution Topics in Stereochemistry. 19: 127-207. DOI: 10.1002/9780470147283.Ch3  0.524
2006 Ricardo A, Frye F, Carrigan MA, Tipton JD, Powell DH, Benner SA. 2-Hydroxymethylboronate as a reagent to detect carbohydrates: application to the analysis of the formose reaction. The Journal of Organic Chemistry. 71: 9503-5. PMID 17137382 DOI: 10.1021/Jo061770H  0.697
2006 Yang Z, Hutter D, Sheng P, Sismour AM, Benner SA. Artificially expanded genetic information system: a new base pair with an alternative hydrogen bonding pattern. Nucleic Acids Research. 34: 6095-101. PMID 17074747 DOI: 10.1093/Nar/Gkl633  0.796
2006 Leal NA, Sukeda M, Benner SA. Dynamic assembly of primers on nucleic acid templates. Nucleic Acids Research. 34: 4702-10. PMID 16963776 DOI: 10.1093/Nar/Gkl625  0.347
2006 Li T, Chamberlin SG, Caraco MD, Liberles DA, Gaucher EA, Benner SA. Analysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics. Bmc Evolutionary Biology. 6: 25. PMID 16545144 DOI: 10.1186/1471-2148-6-25  0.721
2006 Gaucher EA, De Kee DW, Benner SA. Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family. Bmc Genomics. 7: 44. PMID 16522197 DOI: 10.1186/1471-2164-7-44  0.778
2006 Bradley ME, Benner SA. Integrating protein structures and precomputed genealogies in the Magnum database: examples with cellular retinoid binding proteins. Bmc Bioinformatics. 7: 89. PMID 16504077 DOI: 10.1186/1471-2105-7-89  0.346
2006 Wang L, Yang CJ, Medley CD, Benner SA, Tan W. Locked nucleic acid molecular beacons for intracellular mRNA monitoring Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6095. DOI: 10.1117/12.644649  0.464
2005 Wang L, Yang CJ, Medley CD, Benner SA, Tan W. Locked nucleic acid molecular beacons. Journal of the American Chemical Society. 127: 15664-5. PMID 16277483 DOI: 10.1021/Ja052498G  0.458
2005 Sismour AM, Benner SA. Synthetic biology. Expert Opinion On Biological Therapy. 5: 1409-14. PMID 16255644 DOI: 10.1517/14712598.5.11.1409  0.802
2005 Sismour AM, Benner SA. The use of thymidine analogs to improve the replication of an extra DNA base pair: a synthetic biological system. Nucleic Acids Research. 33: 5640-6. PMID 16192575 DOI: 10.1093/Nar/Gki873  0.797
2005 Li Q, Ricardo A, Benner SA, Winefordner JD, Powell DH. Desorption/ionization on porous silicon mass spectrometry studies on pentose-borate complexes. Analytical Chemistry. 77: 4503-8. PMID 16013866 DOI: 10.1021/Ac050258D  0.684
2005 Benner SA, Sismour AM. Synthetic biology. Nature Reviews. Genetics. 6: 533-43. PMID 15995697 DOI: 10.1038/nrg1637  0.775
2005 Thomson JM, Gaucher EA, Burgan MF, De Kee DW, Li T, Aris JP, Benner SA. Resurrecting ancestral alcohol dehydrogenases from yeast. Nature Genetics. 37: 630-5. PMID 15864308 DOI: 10.1038/Ng1553  0.749
2005 Bradley ME, Benner SA. Phylogenomic approaches to common problems encountered in the analysis of low copy repeats: the sulfotransferase 1A gene family example. Bmc Evolutionary Biology. 5: 22. PMID 15752422 DOI: 10.1186/1471-2148-5-22  0.317
2005 Benner SA, Ricardo A. Planetary systems biology. Molecular Cell. 17: 471-2. PMID 15721248 DOI: 10.1016/J.Molcel.2005.02.005  0.708
2004 Benner SA, Ricardo A, Carrigan MA. Is there a common chemical model for life in the universe? Current Opinion in Chemical Biology. 8: 672-89. PMID 15556414 DOI: 10.1016/J.Cbpa.2004.10.003  0.716
2004 Benner SA. Understanding nucleic acids using synthetic chemistry. Accounts of Chemical Research. 37: 784-97. PMID 15491125 DOI: 10.1021/Ar040004Z  0.351
2004 Carrigan MA, Ricardo A, Ang DN, Benner SA. Quantitative analysis of a RNA-cleaving DNA catalyst obtained via in vitro selection. Biochemistry. 43: 11446-59. PMID 15350131 DOI: 10.1021/Bi049898L  0.735
2004 Gaucher EA, Graddy LG, Li T, Simmen RC, Simmen FA, Schreiber DR, Liberles DA, Janis CM, Benner SA. The planetary biology of cytochrome P450 aromatases. Bmc Biology. 2: 19. PMID 15315709 DOI: 10.1186/1741-7007-2-19  0.8
2004 Chang MS, Benner SA. Empirical analysis of protein insertions and deletions determining parameters for the correct placement of gaps in protein sequence alignments. Journal of Molecular Biology. 341: 617-31. PMID 15276848 DOI: 10.1016/J.Jmb.2004.05.045  0.352
2004 Martinot TA, Benner SA. Artificial genetic systems: exploiting the "aromaticity" formalism to improve the tautomeric ratio for isoguanosine derivatives. The Journal of Organic Chemistry. 69: 3972-5. PMID 15153036 DOI: 10.1021/Jo0497959  0.735
2004 Hendrickson CL, Devine KG, Benner SA. Probing minor groove recognition contacts by DNA polymerases and reverse transcriptases using 3-deaza-2'-deoxyadenosine. Nucleic Acids Research. 32: 2241-50. PMID 15107492 DOI: 10.1093/Nar/Gkh542  0.768
2004 Roychowdhury A, Illangkoon H, Hendrickson CL, Benner SA. 2'-deoxycytidines carrying amino and thiol functionality: synthesis and incorporation by Vent (exo-) polymerase. Organic Letters. 6: 489-92. PMID 14961605 DOI: 10.1021/Ol0360290  0.775
2004 Sismour AM, Lutz S, Park JH, Lutz MJ, Boyer PL, Hughes SH, Benner SA. PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1. Nucleic Acids Research. 32: 728-35. PMID 14757837 DOI: 10.1093/Nar/Gkh241  0.791
2004 Ricardo A, Carrigan MA, Olcott AN, Benner SA. Borate minerals stabilize ribose. Science (New York, N.Y.). 303: 196. PMID 14716004 DOI: 10.1126/Science.1092464  0.718
2004 von Krosigk U, Benner S. Expanding the Genetic Alphabet: Pyrazine Nucleosides That Support a DonorDonorAcceptor Hydrogen-Bonding Pattern Helvetica Chimica Acta. 87: 1299-1324. DOI: 10.1002/Hlca.200490120  0.336
2003 Geyer CR, Battersby TR, Benner SA. Nucleobase pairing in expanded Watson-Crick-like genetic information systems. Structure (London, England : 1993). 11: 1485-98. PMID 14656433 DOI: 10.1016/J.Str.2003.11.008  0.757
2003 Hutter D, Benner SA. Expanding the genetic alphabet: non-epimerizing nucleoside with the pyDDA hydrogen-bonding pattern. The Journal of Organic Chemistry. 68: 9839-42. PMID 14656120 DOI: 10.1021/Jo034900K  0.313
2003 Benner SA, Hutter D, Sismour AM. Synthetic biology with artificially expanded genetic information systems. From personalized medicine to extraterrestrial life. Nucleic Acids Research. Supplement (2001). 125-6. PMID 14510412  0.801
2003 Gaucher EA, Thomson JM, Burgan MF, Benner SA. Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins. Nature. 425: 285-8. PMID 13679914 DOI: 10.1038/Nature01977  0.649
2003 Held HA, Roychowdhury A, Benner SA. C-5 modified nucleosides: direct insertion of alkynyl-thio functionality in pyrimidines. Nucleosides, Nucleotides & Nucleic Acids. 22: 391-404. PMID 12885121 DOI: 10.1081/Ncn-120022030  0.332
2003 Benner SA. Interpretive proteomics--finding biological meaning in genome and proteome databases. Advances in Enzyme Regulation. 43: 271-359. PMID 12791396 DOI: 10.1016/S0065-2571(02)00024-9  0.322
2003 Gaucher EA, Miyamoto MM, Benner SA. Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein. Genetics. 163: 1549-53. PMID 12702697  0.581
2003 Eschgfäller B, Schmidt JG, König M, Benner SA. Synthesis and properties of oligodeoxynucleotide analogs with bis(methylene) sulfone bridges Helvetica Chimica Acta. 86: 2959-2997. DOI: 10.1002/Hlca.200390244  0.344
2002 Held HA, Benner SA. Challenging artificial genetic systems: thymidine analogs with 5-position sulfur functionality. Nucleic Acids Research. 30: 3857-69. PMID 12202771 DOI: 10.1093/Nar/Gkf500  0.395
2002 Gaucher EA, Gu X, Miyamoto MM, Benner SA. Predicting functional divergence in protein evolution by site-specific rate shifts. Trends in Biochemical Sciences. 27: 315-21. PMID 12069792 DOI: 10.1016/S0968-0004(02)02094-7  0.637
2002 Huang Z, Benner SA. Oligodeoxyribonucleotide analogues with bridging dimethylene sulfide, sulfoxide, and sulfone groups. Toward a second-generation model of nucleic acid structure. The Journal of Organic Chemistry. 67: 3996-4013. PMID 12054932 DOI: 10.1021/Jo0003910  0.368
2002 Fukami-Kobayashi K, Schreiber DR, Benner SA. Detecting compensatory covariation signals in protein evolution using reconstructed ancestral sequences. Journal of Molecular Biology. 319: 729-43. PMID 12054866 DOI: 10.1016/S0022-2836(02)00239-5  0.607
2002 Benner SA, Caraco MD, Thomson JM, Gaucher EA. Planetary biology--paleontological, geological, and molecular histories of life. Science (New York, N.Y.). 296: 864-8. PMID 11988562 DOI: 10.1126/Science.1069863  0.629
2002 Benner SA. The past as the key to the present: resurrection of ancient proteins from eosinophils. Proceedings of the National Academy of Sciences of the United States of America. 99: 4760-1. PMID 11959927 DOI: 10.1073/Pnas.092143699  0.33
2002 Benner SA, Hutter D. Phosphates, DNA, and the search for nonterrean life: a second generation model for genetic molecules. Bioorganic Chemistry. 30: 62-80. PMID 11955003 DOI: 10.1006/Bioo.2001.1232  0.41
2002 Gaucher EA, Das UK, Miyamoto MM, Benner SA. The crystal structure of eEF1A refines the functional predictions of an evolutionary analysis of rate changes among elongation factors. Molecular Biology and Evolution. 19: 569-73. PMID 11919299 DOI: 10.1093/Oxfordjournals.Molbev.A004113  0.652
2002 Hutter D, Blaettler MO, Benner SA. From phosphate to bis(methylene) sulfone: Non-ionic backbone linkers in DNA Helvetica Chimica Acta. 85: 2777-2806. DOI: 10.1002/1522-2675(200209)85:9<2777::Aid-Hlca2777>3.0.Co;2-1  0.351
2001 Liberles DA, Schreiber DR, Govindarajan S, Chamberlin SG, Benner SA. The adaptive evolution database (TAED). Genome Biology. 2: RESEARCH0028. PMID 11532212 DOI: 10.1186/Gb-2001-2-8-Research0028  0.722
2001 Rao P, Benner SA. Fluorescent charge-neutral analogue of xanthosine: synthesis of a 2'-deoxyribonucleoside bearing a 5-aza-7-deazaxanthine base. The Journal of Organic Chemistry. 66: 5012-5. PMID 11463249 DOI: 10.1021/Jo005743H  0.311
2001 Benner SA, Gaucher EA. Evolution, language and analogy in functional genomics. Trends in Genetics : Tig. 17: 414-8. PMID 11418223 DOI: 10.1016/S0168-9525(01)02320-4  0.606
2001 Liberles DA, Schreiber DR, Govindarajan S, Chamberlin SG, Benner SA. The Adaptive Evolution Database (TAED). Genome Biology. 2: PREPRINT0003. PMID 11305934  0.709
2001 Gaucher EA, Miyamoto MM, Benner SA. Function-structure analysis of proteins using covarion-based evolutionary approaches: Elongation factors. Proceedings of the National Academy of Sciences of the United States of America. 98: 548-52. PMID 11209054 DOI: 10.1073/Pnas.98.2.548  0.655
2000 Peltier MR, Raley LC, Liberles DA, Benner SA, Hansen PJ. Evolutionary history of the uterine serpins. The Journal of Experimental Zoology. 288: 165-74. PMID 10931499 DOI: 10.1002/1097-010X(20000815)288:2<165::Aid-Jez7>3.0.Co;2-R  0.758
2000 Gonnet GH, Korostensky C, Benner S. Evaluation measures of multiple sequence alignments Journal of Computational Biology. 7: 261-276. PMID 10890401 DOI: 10.1089/10665270050081513  0.32
2000 Benner SA, Chamberlin SG, Liberles DA, Govindarajan S, Knecht L. Functional inferences from reconstructed evolutionary biology involving rectified databases--an evolutionarily grounded approach to functional genomics. Research in Microbiology. 151: 97-106. PMID 10865954 DOI: 10.1016/S0923-2508(00)00123-6  0.587
2000 Jurczyk SC, Horlacher J, Devined KG, Benner SA, Battersby TR. Synthesis and characterization of oligonucleotides containing 2'- deoxyxanthosine using phosphoramidite chemistry Helvetica Chimica Acta. 83: 1517-1524. DOI: 10.1002/1522-2675(20000705)83:7<1517::Aid-Hlca1517>3.0.Co;2-S  0.747
1999 Battersby TR, Ang DN, Burgstaller P, Jurczyk SC, Bowser MT, Buchanan DD, Kennedy RT, Benner SA. Quantitative analysis of receptors for adenosine nucleotides obtained via in vitro selection from a library incorporating a cationic nucleotide analog. Journal of the American Chemical Society. 121: 9781-9. PMID 11543572 DOI: 10.1021/Ja9816436  0.751
1999 Soucek J, Raines RT, Haugg M, Raillard-Yoon SA, Benner SA. Structural changes to ribonuclease A and their effects on biological activity. Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology. 123: 103-11. PMID 10442819 DOI: 10.1016/S0742-8413(99)00005-5  0.323
1999 Lutz MJ, Will DW, Breipohl G, Benner SA, Uhlmann E. Synthesis of a monocharged peptide nucleic acid (PNA) analog and its recognition as substrate by DNA polymerases. Nucleosides & Nucleotides. 18: 393-401. PMID 10408922 DOI: 10.1080/15257779908043084  0.34
1999 Lutz S, Burgstaller P, Benner SA. An in vitro screening technique for DNA polymerases that can incorporate modified nucleotides. Pseudo-thymidine as a substrate for thermostable polymerases. Nucleic Acids Research. 27: 2792-8. PMID 10373598 DOI: 10.1093/Nar/27.13.2792  0.574
1999 Lutz S, Benner SA. Simple one-pot synthesis of a 2'-tritium labeled C-deoxynucleoside. Bioorganic & Medicinal Chemistry Letters. 9: 723-6. PMID 10201836 DOI: 10.1016/S0960-894X(99)00068-2  0.511
1999 Vatzaki EH, Allen SC, Leonidas DD, Trautwein-Fritz K, Stackhouse J, Benner SA, Acharya KR. Crystal structure of a hybrid between ribonuclease A and bovine seminal ribonuclease--the basic surface, at 2.0 A resolution. European Journal of Biochemistry / Febs. 260: 176-82. PMID 10091597 DOI: 10.1046/J.1432-1327.1999.00142.X  0.333
1999 Gerloff DL, Cannarozzi GM, Joachimiak M, Cohen FE, Schreiber D, Benner SA. Evolutionary, mechanistic, and predictive analyses of the hydroxymethyldihydropterin pyrophosphokinase family of proteins. Biochemical and Biophysical Research Communications. 254: 70-6. PMID 9920734 DOI: 10.1006/Bbrc.1998.9884  0.603
1999 Benner SA, Burgstaller P, Battersby TR, Jurczyk S. 6 Did the RNA World Exploit an Expanded Genetic Alphabet Cold Spring Harbor Monograph Archive. 37: 163-181. DOI: 10.1101/087969589.37.163  0.372
1999 Jurczyk SC, Kodra JT, Park JH, Benner SA, Battersby TR. Synthesis of 2'-deoxyisoguanosine 5'-triphosphate and 2'-deoxy-5 methylisocytidine 5'-triphosphate Helvetica Chimica Acta. 82: 1005-1015. DOI: 10.1002/(Sici)1522-2675(19990707)82:7<1005::Aid-Hlca1005>3.0.Co;2-5  0.749
1998 Benner SA, Battersby TR, Eschgfaller B, Hutter D, Kodra JT, Lutz S, Arslan T, Baschlin DK, Blattler M, Egli M, Hammer C, Held HA, Horlacher J, Huang Z, Hyrup B, et al. Redesigning nucleic acids. Pure and Applied Chemistry. Chimie Pure Et Appliquã©E. 70: 263-6. PMID 11542721 DOI: 10.1351/Pac199870020263  0.791
1998 Lutz MJ, Horlacher J, Benner SA. Recognition of a non-standard base pair by thermostable DNA polymerases. Bioorganic & Medicinal Chemistry Letters. 8: 1149-52. PMID 9871725 DOI: 10.1016/S0960-894X(98)00177-2  0.337
1998 Lutz MJ, Horlacher J, Benner SA. Recognition of 2'-deoxyisoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA polymerases. Bioorganic & Medicinal Chemistry Letters. 8: 499-504. PMID 9871606 DOI: 10.1016/S0960-894X(98)00057-2  0.309
1998 Gerloff DL, Joachimiak M, Cohen FE, Cannarozzi GM, Chamberlin SG, Benner SA. Structure prediction in a post-genomic environment: a secondary and tertiary structural model for the initiation factor 5A family. Biochemical and Biophysical Research Communications. 251: 173-81. PMID 9790926 DOI: 10.1006/Bbrc.1998.9198  0.314
1998 Benner SA, Trabesinger N, Schreiber D. Post-genomic science: Converting primary structure into physiological function Advances in Enzyme Regulation. 38: 155-180. PMID 9762352 DOI: 10.1016/S0065-2571(97)00019-8  0.629
1998 Chelvanayagam G, Knecht L, Jenny T, Benner SA, Gonnet GH. A combinatorial distance-constraint approach to predicting protein tertiary models from known secondary structure Folding and Design. 3: 149-160. PMID 9562545 DOI: 10.1016/S1359-0278(98)00023-6  0.306
1998 Opitz JG, Ciglic MI, Haugg M, Trautwein-Fritz K, Raillard SA, Jermann TM, Benner SA. Origin of the catalytic activity of bovine seminal ribonuclease against double-stranded RNA. Biochemistry. 37: 4023-33. PMID 9521723 DOI: 10.1021/Bi9722047  0.372
1998 Ciglic MI, Jackson PJ, Raillard SA, Haugg M, Jermann TM, Opitz JG, Trabesinger-Rüf N, Benner SA. Origin of dimeric structure in the ribonuclease superfamily. Biochemistry. 37: 4008-22. PMID 9521722 DOI: 10.1021/Bi972203E  0.396
1998 Eschgfäller B, König M, Boess F, Boelsterli UA, Benner SA. Synthesis and biodistribution of a short nonionic oligonucleotide analogue in mouse with a potential to mimic peptides Journal of Medicinal Chemistry. 41: 276-283. PMID 9464358 DOI: 10.1021/Jm970538O  0.31
1998 Jurczyk SC, Kodra JT, David Rozzell J, Benner SA, Battersby TR. Synthesis of Oligonucleotides Containing 2′-Deoxyisoguanosine and 2′-Deoxy-5-methylisocytidine Using Phosphoramidite Chemistry Helvetica Chimica Acta. 81: 793-811.  0.722
1997 Chelvanayagam G, Eggenschwiler A, Knecht L, Gonnet GH, Benner SA. An analysis of simultaneous variation in protein structures Protein Engineering. 10: 307-316. PMID 9194155 DOI: 10.1093/Protein/10.4.307  0.317
1997 Gerloff DL, Cohen FE, Korostensky C, Turcotte M, Gonnet GH, Benner SA. A predicted consensus structure for the N-terminal fragment of the heat shock protein HSP90 family. Proteins. 27: 450-8. PMID 9094746 DOI: 10.1002/(Sici)1097-0134(199703)27:3<450::Aid-Prot12>3.0.Co;2-K  0.324
1997 Tauer A, Benner SA. The B12-dependent ribonucleotide reductase from the archaebacterium Thermoplasma acidophila: An evolutionary solution to the ribonucleotide reductase conundrum Proceedings of the National Academy of Sciences of the United States of America. 94: 53-58. PMID 8990160 DOI: 10.1073/Pnas.94.1.53  0.312
1996 Baeschlin DK, Hyrup B, Benner SA, Richert C. Chimera of Dimethylene Sulfone-, Methyl Sulfide-, and Methyl Sulfoxide-Linked Ribonucleotides and DNA. The Journal of Organic Chemistry. 61: 7620-7626. PMID 11667701 DOI: 10.1021/Jo960669H  0.514
1996 Lutz MJ, Held HA, Hottiger M, Hübscher U, Benner SA. Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet. Nucleic Acids Research. 24: 1308-13. PMID 8614635 DOI: 10.1093/Nar/24.7.1308  0.346
1996 Trabesinger-Ruef N, Jermann T, Zankel T, Durrant B, Frank G, Benner SA. Pseudogenes in ribonuclease evolution: A source of new biomacromolecular function? Febs Letters. 382: 319-322. PMID 8605993 DOI: 10.1016/0014-5793(96)00191-3  0.304
1996 Richert C, Roughton AL, Benner SA. Nonionic analogs of RNA with dimethylene sulfone bridges Journal of the American Chemical Society. 118: 4518-4531. DOI: 10.1021/Ja952322M  0.547
1996 Baeschlin DK, Daube M, Blättler MO, Benner SA, Richert C. Four step synthesis of a 5′-deoxy-5′-iodomethylthymidine Tetrahedron Letters. 37: 1591-1592. DOI: 10.1016/0040-4039(96)00090-1  0.523
1996 Voegel JJ, Benner SA. 156. Synthesis, molecular recognition, and enzymology of oligonucleotides containing the non-standard base pair between 5-aza-7-deazaisoguanine and 6-amino-3-methylpyrazin-2(1H)-one, a donor-acceptor-acceptor purine analog and an acceptor-donor-donor pyrimidine analog Helvetica Chimica Acta. 79: 1881-1898. DOI: 10.1002/Hlca.19960790711  0.362
1996 Voegel JJ, Benner SA. 155. Synthesis and characterization of non-standard nucleosides and nucleotides bearing the acceptor-donor-donor pyrimidine analog 6-amino-3-methylpyrazin-2(1H)-one Helvetica Chimica Acta. 79: 1863-1880. DOI: 10.1002/Hlca.19960790710  0.321
1995 Gerloff DL, Benner SA. A consensus prediction of the secondary structure for the 6-phospho-β-D- galactosidase superfamily Proteins: Structure, Function and Genetics. 21: 273-281. PMID 7567950 DOI: 10.1002/Prot.340210402  0.302
1995 Hyrup B, Richert C, Schulte-herbrüggen T, Benner SA, Egli M. X-ray crystal struture of a dimethylene sulfone-bridged ribonucleotide dimer in a single-stranded state Nucleic Acids Research. 23: 2427-2433. PMID 7543197 DOI: 10.1093/Nar/23.13.2427  0.538
1995 Horlacher J, Hottiger M, Podust VN, Hübscher U, Benner SA. Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns Proceedings of the National Academy of Sciences of the United States of America. 92: 6329-6333. PMID 7541538 DOI: 10.1073/Pnas.92.14.6329  0.323
1995 Jermann TM, Opitz JG, Stackhouse J, Benner SA. Reconstructing the evolutionary history of the artiodactyl ribonuclease superfamily Nature. 374: 57-59. PMID 7532788 DOI: 10.1038/374057A0  0.333
1994 Benner SA, Badcoe I, Cohen MA, Gerloff DL. Bona fide prediction of aspects of protein conformation. Assigning interior and surface residues from patterns of variation and conservation in homologous protein sequences. Journal of Molecular Biology. 235: 926-58. PMID 8289328 DOI: 10.1006/Jmbi.1994.1049  0.33
1994 Gonnet GH, Cohen MA, Benner SA. Analysis of amino acid substitution during divergent evolution: the 400 by 400 dipeptide substitution matrix. Biochemical and Biophysical Research Communications. 199: 489-96. PMID 8135790 DOI: 10.1006/Bbrc.1994.1255  0.331
1994 Benner SA, Jenny TF, Cohen MA, Gonnet GH. Predicting the conformation of proteins from sequences. Progress and future progress. Advances in Enzyme Regulation. 34: 269-353. PMID 7942279 DOI: 10.1016/0065-2571(94)90021-3  0.329
1994 Voegel JJ, Benner SA. Nonstandard hydrogen bonding in duplex oligonucleotides. The base pair between an acceptor-donor-donor pyrimidine analog and a donor-acceptor-acceptor purine analog Journal of the American Chemical Society. 116: 6929-6230. DOI: 10.1021/Ja00094A055  0.305
1994 Heeb NV, Benner SA. Guanosine derivatives bearing an N2-3-imidazolepropionic acid Tetrahedron Letters. 35: 3045-3048. DOI: 10.1016/S0040-4039(00)76823-7  0.309
1993 Benner SA, Cohen MA, Gonnet GH. Empirical and structural models for insertions and deletions in the divergent evolution of proteins. Journal of Molecular Biology. 229: 1065-82. PMID 8445636 DOI: 10.1006/Jmbi.1993.1105  0.332
1993 Johnsson K, Allemann RK, Widmer H, Benner SA. Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides Nature. 365: 530-532. PMID 8413606 DOI: 10.1038/365530A0  0.698
1993 Switzer CY, Moroney SE, Benner SA. Enzymatic recognition of the base pair between isocytidine and isoguanosine. Biochemistry. 32: 10489-96. PMID 7691174 DOI: 10.1021/Bi00090A027  0.661
1993 Benner SA, Cohen MA, Gerloff D. Predicted secondary structure for the Src homology 3 domain. Journal of Molecular Biology. 229: 295-305. PMID 7679147 DOI: 10.1006/Jmbi.1993.1035  0.307
1993 Benner SA, Cohen MA, Gonnet GH, Berkowitz DB, Johnsson KP. 2 Reading the Palimpsest: Contemporary Biochemical Data and the RNA World Cold Spring Harbor Monograph Archive. 24: 27-70. DOI: 10.1101/087969380.24.27  0.614
1993 Voegel JJ, von Krosigk U, Benner SA. Synthesis and tautomeric equilibrium of 6-amino-5-benzyl-3-methylpyrazin-2-one. An acceptor-donor-donor nucleoside base analog The Journal of Organic Chemistry. 58: 7542-7547. DOI: 10.1021/Jo00078A038  0.349
1993 Arslan T, Herradon B, Schweizer BW, Benner SA. Determination of the absolute configuration of dimethyl (2S,3S)-2-allyl-3-hydroxyglutarate: A chiral building block for preparing branched-chain nucleoside analogues Helvetica Chimica Acta. 76: 2969-2975. DOI: 10.1002/Hlca.19930760821  0.717
1993 Voegel JJ, Altorfer MM, Benner SA. The Donor-Acceptor-Acceptor Purine Analog: Transformation of 5-aza-7-deaza-1H-isoguanine (=4-aminoimidazo-[1,2-a]-1,3,5-triazin-2(1H)-one) to 2?-deoxy-5-aza-7-deaza-isoguanosine using purine nucleoside phosphorylase Helvetica Chimica Acta. 76: 2061-2069. DOI: 10.1002/Hlca.19930760520  0.302
1993 Jenny TF, Benner SA. Carbocyclic Analogs of Nucleosides. Part 4. Preparation of enantiomerically pure analogs of purine nucleosides for the synthesis of sulfone-linked oligonucleotide analogs Helvetica Chimica Acta. 76: 826-841. DOI: 10.1002/Hlca.19930760207  0.313
1992 Gonnet GH, Cohen MA, Benner SA. Exhaustive matching of the entire protein sequence database. Science (New York, N.Y.). 256: 1443-5. PMID 1604319 DOI: 10.1126/Science.1604319  0.312
1992 Bain JD, Switzer C, Chamberlin AR, Benner SA. Ribosome-mediated incorporation of a non-standard amino acid into a peptide through expansion of the genetic code. Nature. 356: 537-9. PMID 1560827 DOI: 10.1038/356537A0  0.663
1991 Weinhold EG, Glasfeld A, Ellington AD, Benner SA. Structural determinants of stereospecificity in yeast alcohol dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 88: 8420-4. PMID 1924300 DOI: 10.1073/Pnas.88.19.8420  0.731
1991 Benner SA, Gerloff D. Patterns of divergence in homologous proteins as indicators of secondary and tertiary structure: A prediction of the structure of the catalytic domain of protein kinases Advances in Enzyme Regulation. 31: 121-181. PMID 1877385 DOI: 10.1016/0065-2571(91)90012-B  0.303
1991 Allemann RK, Presnell SR, Benner SA. A hybrid of bovine pancreatic ribonuclease and human angiogenin: An external loop as a module controlling substrate specificity? Protein Engineering, Design and Selection. 4: 831-835. PMID 1798706 DOI: 10.1093/Protein/4.7.831  0.591
1991 Piccirilli JA, Moroney SE, Benner SA. A C-nucleotide base pair: methylpseudouridine-directed incorporation of formycin triphosphate into RNA catalyzed by T7 RNA polymerase. Biochemistry. 30: 10350-6. PMID 1718418 DOI: 10.1021/Bi00106A037  0.586
1991 Green R, Szostak JW, Benner SA, Rich A, Usman N. Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. Nucleic Acids Research. 19: 4161-6. PMID 1714564 DOI: 10.1093/Nar/19.15.4161  0.531
1991 Piccirilli JA, Krauch T, MacPherson LJ, Benner SA. A Direct Route to 3-(D-Ribofuranosyl)pyridine Nucleosides Helvetica Chimica Acta. 74: 397-406. DOI: 10.1002/Hlca.19910740217  0.516
1990 Glasfeld A, Leanz GF, Benner SA. The stereospecificities of seven dehydrogenases from Acholeplasma laidlawii. The simplest historical model that explains dehydrogenase stereospecificity. The Journal of Biological Chemistry. 265: 11692-9. PMID 2365693  0.672
1990 Stackhouse J, Presnell SR, McGeehan GM, Nambiar KP, Benner SA. The ribonuclease from an extinct bovid ruminant Febs Letters. 262: 104-106. PMID 2318301 DOI: 10.1016/0014-5793(90)80164-E  0.308
1990 Schein CH, Haugg M, Benner SA. Interferon-γ activates the cleavage of double-stranded RNA by bovine seminal ribonuclease Febs Letters. 270: 229-232. PMID 2121524 DOI: 10.1016/0014-5793(90)81275-S  0.31
1990 Piccirilli JA, Krauch T, Moroney SE, Benner SA. Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet. Nature. 343: 33-7. PMID 1688644 DOI: 10.1038/343033A0  0.606
1989 Benner S, Ellington AD. Interpreting the behavior of enzymes: purpose or pedigree? Crc Critical Reviews in Biochemistry. 23: 369-426. PMID 3067974 DOI: 10.3109/10409238809082549  0.498
1989 Glasfeld A, Benner SA. The stereospecificity of the ferrous-ion-dependent alcohol dehydrogenase from Zymomonas mobilis. European Journal of Biochemistry / Febs. 180: 373-5. PMID 2924772 DOI: 10.1111/J.1432-1033.1989.Tb14658.X  0.675
1989 Benner SA. Patterns of divergence in homologous proteins as indicators of tertiary and quaternary structure Advances in Enzyme Regulation. 28. PMID 2624173 DOI: 10.1016/0065-2571(89)90073-3  0.302
1989 Benner SA, Allemann RK. The return of pancreatic ribonucleases Trends in Biochemical Sciences. 14: 396-397. PMID 2479128 DOI: 10.1016/0968-0004(89)90282-X  0.553
1989 Benner SA, Ellington AD, Tauer A. Modern metabolism as a palimpsest of the RNA world Proceedings of the National Academy of Sciences of the United States of America. 86: 7054-7058. PMID 2476811 DOI: 10.1073/Pnas.86.18.7054  0.51
1989 Switzer C, Moroney SE, Benner SA. Enzymatic incorporation of a new base pair into DNA and RNA Journal of the American Chemical Society. 111: 8322-8323. DOI: 10.1021/Ja00203A067  0.668
1988 Benner SA, Ellington AD. Return of the 'last ribo-organism' [7] Nature. 332: 688-689. PMID 2451785 DOI: 10.1038/332688B0  0.422
1988 Presnell SR, Benner SA. The design of syntetic genes Nucleic Acids Research. 16: 1693-1702. PMID 2451218 DOI: 10.1093/Nar/16.5.1693  0.313
1988 Allemann RK, Hung R, Benner SA. Stereochemical profile of the dehydrogenases of Drosophila melanogaster Journal of the American Chemical Society. 110: 5555-5560. DOI: 10.1021/Ja00224A046  0.549
1988 Glasfeld A, Zbinden P, Dobler M, Benner SA, Dunitz JD. Crystal structures of two simple N-substituted dihydronicotinamides: Possible implications for stereoelectronic arguments in enzymology Journal of the American Chemical Society. 110: 5152-5157. DOI: 10.1021/Ja00223A040  0.68
1987 Berkowitz DB, Benner SA. Anomeric specificity of L-fucose dehydrogenase: a stereochemical imperative in aldopyranose dehydrogenases? Biochemistry. 26: 2606-11. PMID 3607036 DOI: 10.1021/Bi00383A029  0.523
1987 Ellington AD, Benner SA. Free energy differences between enzyme bound states Journal of Theoretical Biology. 127: 491-506. PMID 3444340 DOI: 10.1016/S0022-5193(87)80145-5  0.45
1987 Benner SA, Allemann RK, Ellington AD, Ge L, Glasfeld A, Leanz GF, Krauch T, MacPherson LJ, Moroney S, Piccirilli JA. Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry. Cold Spring Harbor Symposia On Quantitative Biology. 52: 53-63. PMID 2456885 DOI: 10.1101/Sqb.1987.052.01.009  0.792
1987 Benner SA, Ellington AD. The last ribo-organism [9] Nature. 329: 295-296. PMID 2442624 DOI: 10.1038/329295A0  0.42
1987 Piccirilli JA, Rozzell JD, Benner SA. The stereospecificity of oxaloacetate decarboxylase: a stereochemical imperative? Journal of the American Chemical Society. 109: 8084-8085. DOI: 10.1021/Ja00260A023  0.513
1984 Nambiar KP, Stackhouse J, Stauffer DM, Kennedy WP, Eldredge JK, Benner SA. Total synthesis and cloning of a gene coding for the ribonuclease S protein Science. 223: 1299-1301. PMID 6322300 DOI: 10.1126/Science.6322300  0.307
Low-probability matches (unlikely to be authored by this person)
1994 Jenny TF, Benner SA. Evaluating predictions of secondary structure in proteins Biochemical and Biophysical Research Communications. 200: 149-155. PMID 8166681 DOI: 10.1006/Bbrc.1994.1427  0.3
1993 Benner SA, Gerloff DL. Predicting the conformation of proteins man versus machine Febs Letters. 325: 29-33. PMID 8513889 DOI: 10.1016/0014-5793(93)81408-R  0.299
2017 Biondi E, Furukawa Y, Kawai J, Benner SA. Adsorption of RNA on mineral surfaces and mineral precipitates. Beilstein Journal of Organic Chemistry. 13: 393-404. PMID 28382177 DOI: 10.3762/Bjoc.13.42  0.297
2003 Schmidt J, Eschgfäller B, Benner SA. A direct synthesis of nucleoside analogs homologated at the 3′- and 5′-positions Helvetica Chimica Acta. 86: 2937-2958. DOI: 10.1002/Hlca.200390243  0.295
1993 Gerloff DL, Jenny TF, Knecht LJ, Gonnet GH, Benner SA. The nitrogenase MoFe protein. A secondary structure prediction Febs Letters. 318: 118-124. PMID 8440368 DOI: 10.1016/0014-5793(93)80004-E  0.294
1997 Benner SA, Cannarozzi G, Gerloff D, Turcotte M, Chelvanayagam G. Bona Fide Predictions of Protein Secondary Structure Using Transparent Analyses of Multiple Sequence Alignments. Chemical Reviews. 97: 2725-2844. PMID 11851479 DOI: 10.1021/Cr940469A  0.293
2010 Bedau M, Church G, Rasmussen S, Caplan A, Benner S, Fussenegger M, Collins J, Deamer D. Life after the synthetic cell. Nature. 465: 422-4. PMID 20495545 DOI: 10.1038/465422A  0.293
2010 Hoshika S, Chen F, Leal NA, Benner SA. Artificial genetic systems: self-avoiding DNA in PCR and multiplexed PCR. Angewandte Chemie (International Ed. in English). 49: 5554-7. PMID 20586087 DOI: 10.1002/Anie.201001977  0.293
1995 Jenny TF, Gerloff DL, Cohen MA, Benner SA. Predicted secondary and supersecondary structure for the serine-threonine-specific protein phosphatase family. Proteins. 21: 1-10. PMID 7716164 DOI: 10.1002/Prot.340210102  0.291
1998 Blattler MO, Wenz C, Pingoud A, Benner SA. Distorting duplex DNA by dimethylenesulfone substitution: A new class of 'transition state analog' inhibitors for restriction enzymes [13] Journal of the American Chemical Society. 120: 2674-2675. DOI: 10.1021/Ja972768Y  0.29
2016 Kim HJ, Furukawa Y, Kakegawa T, Bita A, Scorei R, Benner SA. Evaporite Borate-Containing Mineral Ensembles Make Phosphate Available and Regiospecifically Phosphorylate Ribonucleosides: Borate as a Multifaceted Problem Solver in Prebiotic Chemistry. Angewandte Chemie (International Ed. in English). PMID 27862722 DOI: 10.1002/Anie.201608001  0.289
1997 Lutz MJ, Benner SA, Hein S, Breipohl G, Uhlmann E. Recognition of uncharged polyamide-linked nucleic acid analogs by DNA polymerases and reverse transcriptases Journal of the American Chemical Society. 119: 3177-3178. DOI: 10.1021/Ja9637457  0.288
2018 Yaren O, Alto BW, Bradley KM, Moussatche P, Glushakova L, Benner SA. Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1. Journal of Visualized Experiments : Jove. PMID 29608170 DOI: 10.3791/57051  0.287
2018 Biondi E, Howell L, Benner S. Opal Adsorbs and Stabilizes RNA – A Hierarchy of Prebiotic Silica Minerals Synlett. 29: 256-256. DOI: 10.1055/S-0036-1589524  0.287
2016 Winiger CB, Shaw RW, Kim MJ, Moses JD, Matsuura MF, Benner SA. Expanded Genetic Alphabets. Managing Nucleotides that Lack Tautomeric, Protonated, or Deprotonated Versions Complementary to Natural Nucleotides. Acs Synthetic Biology. PMID 27648724 DOI: 10.1021/Acssynbio.6B00193  0.286
2020 Yang Z, Le JT, Hutter D, Bradley KM, Overton BR, McLendon C, Benner SA. Eliminating primer dimers and improving SNP detection using self-avoiding molecular recognition systems. Biology Methods & Protocols. 5: bpaa004. PMID 32395633 DOI: 10.1093/Biomethods/Bpaa004  0.286
1988 Benner SA. Extracellular 'communicator RNA' Febs Letters. 233: 225-228. PMID 2454845 DOI: 10.1016/0014-5793(88)80431-9  0.285
1995 Gerloff DL, Chelvanayagam G, Benner SA. A predicted consensus structure for the protein kinase C2 homology (C2H) domain, the repeating unit of synaptotagmin Proteins: Structure, Function and Genetics. 22: 299-310. PMID 7479705 DOI: 10.1002/Prot.340220402  0.285
1995 Benner SA, Gerloff D, Chelvanayagam G. The phospho-β-galactosidase and synaptotagmin predictions Proteins: Structure, Function and Genetics. 23: 446-453. PMID 8710837 DOI: 10.1002/Prot.340230318  0.283
1993 Arslan T, Benner SA. Reduction of 2-substituted 3-oxoglutarates mediated by baker's yeast. Variation in enantioselectivity without corresponding variation in diastereoselectivity Journal of Organic Chemistry. 58: 2260-2264. DOI: 10.1021/Jo00060A048  0.283
2012 Benner SA. Aesthetics in synthesis and synthetic biology. Current Opinion in Chemical Biology. 16: 581-5. PMID 23196149 DOI: 10.1016/J.Cbpa.2012.11.004  0.282
2017 Glushakova LG, Alto BW, Kim MS, Bradley A, Yaren O, Benner SA. Detection of chikungunya viral RNA in mosquito bodies on cationic (Q) paper based on innovations in synthetic biology. Journal of Virological Methods. PMID 28457785 DOI: 10.1016/J.Jviromet.2017.04.013  0.282
1993 Gerloff DL, Jenny TF, Knecht LJ, Benner SA. A Secondary Structure Prediction of the Hemorrhagic Metalloprotease Family Biochemical and Biophysical Research Communications. 194: 560-565. PMID 8333870 DOI: 10.1006/Bbrc.1993.1856  0.281
2003 Benner SA. Synthetic biology: Act natural. Nature. 421: 118. PMID 12520282 DOI: 10.1038/421118A  0.281
1992 Jenny TF, Horlacher J, Previsani N, Benner SA. Carbocyclic analogs of nucleosides. Synthesis of 2',3'-dideoxy-5'-homonucleoside analogs Helvetica Chimica Acta. 75: 1944-1954. DOI: 10.1002/Hlca.19920750620  0.28
1994 Jenny TF, Benner SA. A prediction of the secondary structure of the pleckstrin homology domain Proteins: Structure, Function and Genetics. 20: 1-3. PMID 7824519 DOI: 10.1002/Prot.340200102  0.279
1997 Gerloff DL, Cohen FE, Benner SA. A predicted consensus structure for the C terminus of the beta and gamma chains of fibrinogen. Proteins. 27: 279-89. PMID 9061791 DOI: 10.1002/(Sici)1097-0134(199702)27:2<279::Aid-Prot13>3.0.Co;2-J  0.279
1992 Moradian A, Benner SA. A biomimetic biotechnological process for converting starch to fructose: thermodynamic and evolutionary considerations in applied enzymology. Journal of the American Chemical Society. 114: 6980-6987. DOI: 10.1021/Ja00044A005  0.276
2004 Johnson SC, Marshall DJ, Harms G, Miller CM, Sherrill CB, Beaty EL, Lederer SA, Roesch EB, Madsen G, Hoffman GL, Laessig RH, Kopish GJ, Baker MW, Benner SA, Farrell PM, et al. Multiplexed genetic analysis using an expanded genetic alphabet. Clinical Chemistry. 50: 2019-27. PMID 15319316 DOI: 10.1373/Clinchem.2004.034330  0.276
1996 Benner SA, Jermann TM, Opitz JG, Raillard SA, Zankel TR, Trautwein-Fritz K, Stackhouse J, Ciglic MI, Haugg M, Trabesinger-Rüf N, Weinhold EG. Developing new synthetic catalysts. How nature does it Acta Chemica Scandinavica. 50: 243-248. PMID 8901176 DOI: 10.3891/Acta.Chem.Scand.50-0243  0.276
2010 Kim HJ, Benner SA. Comment on "The silicate-mediated formose reaction: bottom-up synthesis of sugar silicates". Science (New York, N.Y.). 329: 902; author reply 90. PMID 20724620 DOI: 10.1126/Science.1188697  0.271
2006 Wellington KW, Benner SA. A review: synthesis of aryl C-glycosides via the heck coupling reaction. Nucleosides, Nucleotides & Nucleic Acids. 25: 1309-33. PMID 17067955 DOI: 10.1080/15257770600917013  0.271
2023 Oh J, Shan Z, Hoshika S, Xu J, Chong J, Benner SA, Lyumkis D, Wang D. A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase. Nature Communications. 14: 8219. PMID 38086811 DOI: 10.1038/s41467-023-43735-9  0.27
2012 Blaby IK, Lyons BJ, Wroclawska-Hughes E, Phillips GC, Pyle TP, Chamberlin SG, Benner SA, Lyons TJ, Crécy-Lagard Vd, Crécy Ed. Experimental evolution of a facultative thermophile from a mesophilic ancestor. Applied and Environmental Microbiology. 78: 144-55. PMID 22020511 DOI: 10.1128/Aem.05773-11  0.27
2015 Furukawa Y, Kim HJ, Hutter D, Benner SA. Abiotic regioselective phosphorylation of adenosine with borate in formamide. Astrobiology. 15: 259-67. PMID 25826074 DOI: 10.1089/Ast.2014.1209  0.269
1991 Jenny TF, Previsani N, Benner SA. Carbocyclic analogs of nucleosides via modified Mitsunobu reactions Tetrahedron Letters. 32: 7029-7032. DOI: 10.1016/0040-4039(91)85031-Y  0.269
2000 Benner SA, Devine KG, Matveeva LN, Powell DH. The missing organic molecules on Mars. Proceedings of the National Academy of Sciences of the United States of America. 97: 2425-30. PMID 10706606 DOI: 10.1073/Pnas.040539497  0.267
1998 Jurczyk SC, Kodra JT, Rozzell JD, Benner SA, Battersby TR. Synthesis of Oligonucleotides Containing 2′‐Deoxyisoguanosine and 2′‐Deoxy‐5‐methylisocytidine Using Phosphoramidite Chemistry Helvetica Chimica Acta. 81: 793-811. DOI: 10.1002/Hlca.19980810502  0.267
2023 Benner SA. Rethinking nucleic acids from their origins to their applications. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 378: 20220027. PMID 36633284 DOI: 10.1098/rstb.2022.0027  0.266
1981 Polavarapu PL, Nafie LA, Benner SA, Morton TH. Optical activity due to isotopic substitution. Vibrational circular dichroism and the absolute configurations of .alpha.-deuterated cyclohexanones Journal of the American Chemical Society. 103: 5349-5354. DOI: 10.1021/Ja00408A012  0.266
2023 Benner S, Wang B, Bradley K, Kim MJ, Laos R, Chen C, Gerloff D, Manfio L, Yang Z. Enzyme-Assisted High Throughput Sequencing of an Expanded Genetic Alphabet at Single Base Resolution. Research Square. PMID 38196584 DOI: 10.21203/rs.3.rs-3678081/v1  0.266
2008 Benner S. Biology from the bottom up Nature. 452: 692-694. DOI: 10.1038/452692A  0.265
2004 Benner SA. Chemistry. Redesigning genetics. Science (New York, N.Y.). 306: 625-6. PMID 15499002 DOI: 10.1126/Science.1101104  0.263
2000 Benner SA. Unite efforts and conquer mysteries of artificial genetics. Science (New York, N.Y.). 290: 1506. PMID 11185506 DOI: 10.1126/Science.290.5496.1506  0.262
2003 Des Marais DJ, Allamandola LJ, Benner SA, Boss AP, Deamer D, Falkowski PG, Farmer JD, Hedges SB, Jakosky BM, Knoll AH, Liskowsky DR, Meadows VS, Meyer MA, Pilcher CB, Nealson KH, et al. The NASA Astrobiology Roadmap. Astrobiology. 3: 219-35. PMID 14577870 DOI: 10.1089/153110703769016299  0.261
1983 Rozzell JD, Benner SA. Combining enzymatic and chemical steps in the synthesis of biochemically valuable compounds: isotopically chiral methyl acetate The Journal of Organic Chemistry. 48: 1190-1193. DOI: 10.1021/Jo00156A009  0.26
2009 Johnson RJ, Sautin YY, Oliver WJ, Roncal C, Mu W, Gabriela Sanchez-Lozada L, Rodriguez-Iturbe B, Nakagawa T, Benner SA. Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. 179: 67-76. PMID 18649082 DOI: 10.1007/S00360-008-0291-7  0.257
1991 Trautwein K, Holliger P, Stackhouse J, Benner SA. Site-directed mutagenesis of bovine pancreatic ribonuclease: Lysine-41 and aspartate-121 Febs Letters. 281: 275-277. PMID 1901803 DOI: 10.1016/0014-5793(91)80410-5  0.256
2009 Kim HJ, Leal NA, Benner SA. 2'-deoxy-1-methylpseudocytidine, a stable analog of 2'-deoxy-5-methylisocytidine. Bioorganic & Medicinal Chemistry. 17: 3728-32. PMID 19394831 DOI: 10.1016/J.Bmc.2009.03.047  0.256
1995 Matousek J, Soucek J, Riha J, Zankel TR, Benner SA. Immunosuppressive activity of angiogenin in comparison with bovine seminal ribonuclease and pancreatic ribonuclease Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 112: 235-241. PMID 7584854 DOI: 10.1016/0305-0491(95)00075-5  0.256
2015 Carrigan MA, Uryasev O, Frye CB, Eckman BL, Myers CR, Hurley TD, Benner SA. Hominids adapted to metabolize ethanol long before human-directed fermentation. Proceedings of the National Academy of Sciences of the United States of America. 112: 458-63. PMID 25453080 DOI: 10.1073/Pnas.1404167111  0.255
1989 McGeehan GM, Benner SA. An improved system for expressing pancreatic ribonuclease in Escherichia coli Febs Letters. 247: 55-56. PMID 2523320 DOI: 10.1016/0014-5793(89)81239-6  0.255
1989 Benner SA. Enzyme kinetics and molecular evolution Chemical Reviews. 89: 789-806. DOI: 10.1021/Cr00094A004  0.254
1999 Benner SA. ORIGINS OF LIFE:Old Views of Ancient Events Science. 283: 2026a-2026. DOI: 10.1126/Science.283.5410.2026A  0.253
2023 Li Y, Abraham C, Suslov O, Yaren O, Shaw RW, Kim MJ, Wan S, Marliere P, Benner SA. Synthetic Biology Pathway to Nucleoside Triphosphates for Expanded Genetic Alphabets. Acs Synthetic Biology. PMID 37227319 DOI: 10.1021/acssynbio.3c00060  0.251
1999 Zepik HH, Benner SA. Catalysts, Anticatalysts, and Receptors for Unactivated Phosphate Diesters in Water. The Journal of Organic Chemistry. 64: 8080-8083. PMID 11674719 DOI: 10.1021/Jo982418+  0.251
2009 Davies PC, Benner SA, Cleland CE, Lineweaver CH, McKay CP, Wolfe-Simon F. Signatures of a shadow biosphere. Astrobiology. 9: 241-9. PMID 19292603 DOI: 10.1089/Ast.2008.0251  0.25
1991 Huang Z, Schneider KC, Benner SA. Building blocks for oligonucleotide analogs with dimethylene sulfide, sulfoxide, and sulfone groups replacing phosphodiester linkages The Journal of Organic Chemistry. 56: 3869-3882. DOI: 10.1021/Jo00012A018  0.25
1990 Benner SA. Erweiterung des genetischen Alphabets Nachrichten Aus Chemie, Technik Und Laboratorium. 38: 442-444. DOI: 10.1002/Nadc.19900380405  0.248
1983 Nambiar KP, Stauffer DM, Kolodziej PA, Benner SA. A mechanistic basis for the stereoselectivity of enzymic transfer of hydrogen from nicotinamide cofactors Journal of the American Chemical Society. 105: 5886-5890. DOI: 10.1002/Chin.198350328  0.248
1998 Giger T, Wigger M, Audétat S, Benner SA. Libraries for Receptor-Assisted Combinatorial Synthesis (RACS). The olefin metathesis reaction Synlett. 688-691. DOI: 10.1055/S-1998-1737  0.246
2018 Glushakova LG, Alto BW, Kim MS, Wiggins K, Eastmond B, Moussatche P, Burkett-Cadena ND, Benner SA. Optimization of cationic (Q)-paper for detection of arboviruses in infected mosquitoes. Journal of Virological Methods. 261: 71-79. PMID 30099053 DOI: 10.1016/J.Jviromet.2018.08.004  0.246
1994 Benner SA, Gerloff DL, Jenny TF. Predicting protein crystal structures [3] Science. 265: 1642-1644. PMID 8085149 DOI: 10.1126/Science.8085149  0.246
1990 Schneider KC, Benner SA. Oligonucleotides containing flexible nucleoside analogs Journal of the American Chemical Society. 112: 453-455. DOI: 10.1021/Ja00157A073  0.243
2010 Benner SA. Q&A: Life, synthetic biology and risk. Bmc Biology. 8: 77. PMID 20594289 DOI: 10.1186/1741-7007-8-77  0.242
2020 Ouaray Z, Benner SA, Georgiadis MM, Richards NGJ. Building better polymerases: Engineering the replication of expanded genetic alphabets. The Journal of Biological Chemistry. 295: 17046-17059. PMID 33453957 DOI: 10.1074/jbc.REV120.013745  0.242
2023 Thomas CA, Craig JM, Hoshika S, Brinkerhoff H, Huang JR, Abell SJ, Kim HC, Franzi MC, Carrasco JD, Kim HJ, Smith DC, Gundlach JH, Benner SA, Laszlo AH. Assessing Readability of an 8-Letter Expanded Deoxyribonucleic Acid Alphabet with Nanopores. Journal of the American Chemical Society. PMID 37036666 DOI: 10.1021/jacs.3c00829  0.241
1993 Huang Z, Schneider KC, Benner SA. Oligonucleotide analogs with dimethylenesulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages Methods in Molecular Biology (Clifton, N.J.). 20: 315-353. PMID 8242143 DOI: 10.1385/0-89603-281-7:315  0.241
2020 Ouaray Z, Benner SA, Georgiadis MM, Richards NGJ. Building better DNA polymerases: Engineering the replication of expanded genetic alphabets. The Journal of Biological Chemistry. PMID 33004440 DOI: 10.1074/jbc.REV120.013745  0.24
1992 Jenny TF, Christian Schneider K, Benner SA. N2-isobutyryl-06-[2-(p-nitrophenyl)ethyl]guanine: A new building block for the efficient synthesis of carbocyclic guanosineanalogs Nucleosides and Nucleotides. 11: 1257-1261. DOI: 10.1080/07328319208018340  0.24
2023 Kawabe H, Thomas CA, Hoshika S, Kim MJ, Kim MS, Miessner L, Kaplan N, Craig JM, Gundlach JH, Laszlo AH, Benner SA, Marchand JA. Enzymatic synthesis and nanopore sequencing of 12-letter supernumerary DNA. Nature Communications. 14: 6820. PMID 37884513 DOI: 10.1038/s41467-023-42406-z  0.239
2016 Kim H, Furukawa Y, Kakegawa T, Bita A, Scorei R, Benner SA. Cover Picture: Evaporite Borate-Containing Mineral Ensembles Make Phosphate Available and Regiospecifically Phosphorylate Ribonucleosides: Borate as a Multifaceted Problem Solver in Prebiotic Chemistry (Angew. Chem. Int. Ed. 51/2016) Angewandte Chemie International Edition. 55: 15683-15683. DOI: 10.1002/Anie.201610992  0.239
1984 Rozzell JD, Benner SA. Stereochemical imperative in enzymic decarboxylations. Stereochemical course of the decarboxylation catalyzed by acetoacetate decarboxylase Journal of the American Chemical Society. 106: 4937-4941. DOI: 10.1021/Ja00329A051  0.239
1997 Kodra JT, Benner SA. Synthesis Of An N-Alkyl Derivative Of 2'-Deoxyisoguanosine Synlett. 1997: 939-940. DOI: 10.1055/S-1997-952  0.238
2023 Shukla MS, Hoshika S, Benner SA, Georgiadis MM. Crystal structures of 'ALternative Isoinformational ENgineered' DNA in B-form. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 378: 20220028. PMID 36633282 DOI: 10.1098/rstb.2022.0028  0.237
1981 Benner SA, Maggio JE, Simmons HE. Rearrangement of a geometrically restricted triepoxide to the first topologically nonplanar molecule: A reaction path elucidated by using oxygen isotope effects on carbon-13 chemical shifts Journal of the American Chemical Society. 103: 1581-1582. DOI: 10.1021/Ja00396A058  0.236
1981 Benner SA, Morton TH. Analogs for acetoacetate as an enzyme substrate. Stereochemical preferences Journal of the American Chemical Society. 103: 991-993. DOI: 10.1021/Ja00394A070  0.235
2016 Kim H, Furukawa Y, Kakegawa T, Bita A, Scorei R, Benner SA. Titelbild: Evaporite Borate-Containing Mineral Ensembles Make Phosphate Available and Regiospecifically Phosphorylate Ribonucleosides: Borate as a Multifaceted Problem Solver in Prebiotic Chemistry (Angew. Chem. 51/2016) Angewandte Chemie. 128: 15911-15911. DOI: 10.1002/Ange.201610992  0.235
1995 Weinhold EG, Benner SA. Engineering yeast alcohol dehydrogenase. Replacing Trp54 by leu broadens substrate specificity Protein Engineering. 8: 457-461. PMID 8532667 DOI: 10.1093/Protein/8.5.457  0.234
1995 Roughton AL, Portmann S, Benner SA, Egli M. Crystal structure of a dimethylene sulfone-linked ribodinucleotide analog Journal of the American Chemical Society. 117: 7249-7250. DOI: 10.1021/Ja00132A027  0.234
1997 Wigger M, Nawrocki JP, Watson CH, Eyler JR, Benner SA. Assessing enzyme substrate specificity using combinatorial libraries and electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 11: 1749-52. PMID 9375409 DOI: 10.1002/(Sici)1097-0231(19971030)11:16<1749::Aid-Rcm91>3.0.Co;2-G  0.234
1995 Von Krosigk U, Benner SA. pH-independent triple helix formation by an oligonucleotide containing a pyrazine donor-donor-acceptor base Journal of the American Chemical Society. 117: 5361-5362. DOI: 10.1021/Ja00124A020  0.234
1985 Benner SA, Nambiar KP, Chambers GK. A stereochemical imperative in dehydrogenases: new data and criteria for evaluating function-based theories in bioorganic chemistry Journal of the American Chemical Society. 107: 5513-5517. DOI: 10.1021/Ja00305A031  0.231
2002 Wigger M, Eyler JR, Benner SA, Li W, Marshall AG. Fourier transform-ion cyclotron resonance mass spectrometric resolution, identification, and screening of non-covalent complexes of Hck Src homology 2 domain receptor and ligands from a 324-member peptide combinatorial library. Journal of the American Society For Mass Spectrometry. 13: 1162-9. PMID 12387321 DOI: 10.1016/S1044-0305(02)00439-7  0.23
1981 Benner SA, Rozzell JD, Morton TH. Stereospecificity and stereochemical infidelity of acetoacetate decarboxylase (AAD) Journal of the American Chemical Society. 103: 993-994. DOI: 10.1021/Ja00394A071  0.229
1998 Huang Z, Benner SA. Functionalization of nucleoside analogs: Regiospecific conversion of 4'- hydroxyl groups to thioesters and deoxygenation of 3'-hydroxyl groups Nucleosides and Nucleotides. 17: 895-899. PMID 9708330 DOI: 10.1080/07328319808003461  0.227
1993 Benner S. Book Review: Artificial Life II. A Proceedings Volume in the Santa Fe Institute Studies on the Sciences of Complexity. Edited by C. G. Langton, C. Taylor, J.D. Farmer, and S. Rasmussen Angewandte Chemie International Edition in English. 32: 1372-1372. DOI: 10.1002/Anie.199313721  0.227
1996 Nawrocki JP, Wigger M, Watson CH, Hayes TW, Senko MW, Benner SA, Eyler JR. Analysis of combinatorial libraries using electrospray Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 10: 1860-4. PMID 8953790 DOI: 10.1002/(Sici)1097-0231(199611)10:14<1860::Aid-Rcm770>3.0.Co;2-#  0.226
2019 Glushakova LG, Alto BW, Kim MS, Hutter D, Bradley A, Bradley KM, Burkett-Cadena ND, Benner SA. Multiplexed kit based on Luminex technology and achievements in synthetic biology discriminates Zika, chikungunya, and dengue viruses in mosquitoes. Bmc Infectious Diseases. 19: 418. PMID 31088375 DOI: 10.1186/S12879-019-3998-Z  0.226
2015 Schulze-Makuch D, Rummel JD, Benner SA, Levin G, Parro V, Kounaves S. Nearly Forty Years after Viking: Are We Ready for a New Life-Detection Mission? Astrobiology. 15: 413-9. PMID 26053735 DOI: 10.1089/Ast.2015.1336  0.226
2020 Eberlein L, Beierlein FR, van Eikema Hommes NJR, Radadiya A, Heil J, Benner SA, Clark T, Kast SM, Richards NGJ. Tautomeric Equilibria of Nucleobases in the Hachimoji Expanded Genetic Alphabet. Journal of Chemical Theory and Computation. PMID 32125859 DOI: 10.1021/Acs.Jctc.9B01079  0.225
2019 Kawai J, McLendon DC, Kim H-, Benner SA. Hydroxymethanesulfonate from Volcanic Sulfur Dioxide: A "Mineral" Reservoir for Formaldehyde and Other Simple Carbohydrates in Prebiotic Chemistry. Astrobiology. 19: 506-516. PMID 30615473 DOI: 10.1089/Ast.2017.1800  0.225
1992 Benner SA, Cohen MA, Gerloff D. Correct structure prediction? Nature. 359: 781. PMID 1436052 DOI: 10.1038/359781A0  0.224
1993 Huang Z, Benner SA. Selective Protection and Deprotection Procedures for Thiol and Hydroxyl Groups Synlett. 1993: 83-84. DOI: 10.1055/S-1993-22358  0.224
2022 Hoshika S, Shukla MS, Benner SA, Georgiadis MM. Visualizing "Alternative Isoinformational Engineered" DNA in A- and B-Forms at High Resolution. Journal of the American Chemical Society. PMID 35969672 DOI: 10.1021/jacs.2c05255  0.223
2017 Yaren O, Alto BW, Gangodkar PV, Ranade SR, Patil KN, Bradley KM, Yang Z, Phadke N, Benner SA. Point of sampling detection of Zika virus within a multiplexed kit capable of detecting dengue and chikungunya. Bmc Infectious Diseases. 17: 293. PMID 28427352 DOI: 10.1186/S12879-017-2382-0  0.223
1993 Benner SA. Artificial Life II. A Proceedings Volume in the Santa Fe Institute Studies on the Sciences of Complexity. Herausgegeben von C. G. Langton. C. Taylor, J. D. Farmer und S. Rasmussen. Addison‐Wesley, Redwood City, CA (USA), 1992. XXI, 854 S., geb. 57.95 $. – ISBNO‐201–52570‐4 Angewandte Chemie. 105: 1433-1434. DOI: 10.1002/Ange.19931050947  0.221
1985 Stackhouse J, Nambiar KP, Burbaum JJ, Stauffer DM, Benner SA. Dynamic transduction of energy and internal equilibria in enzymes: a reexamination of pyruvate kinase Journal of the American Chemical Society. 107: 2757-2763. DOI: 10.1021/Ja00295A031  0.221
1993 Gonnet GH, Benner SA. A word in your protein [7] Nature. 361: 121. PMID 8421517 DOI: 10.1038/361121B0  0.22
1993 Benner SA. Catalysis: Design versus selection Science. 261: 1402-1403. PMID 8367723 DOI: 10.1126/Science.8367723  0.219
2009 Wellington KW, Ooi HC, Benner SA. A convenient synthesis of N,N'-dibenzyl-2,4-diaminopyrimidine-2'-deoxyribonucleoside and 1-methyl-2'-deoxypseudoisocytidine. Nucleosides, Nucleotides & Nucleic Acids. 28: 275-91. PMID 20183581 DOI: 10.1080/15257770902946090  0.216
1994 Benner SA. Expanding the genetic lexicon: Incorporating non-standard amino acids into proteins by ribosome-based synthesis Trends in Biotechnology. 12: 158-163. PMID 7764897 DOI: 10.1016/0167-7799(94)90076-0  0.213
2012 Carrigan MA, Uryasev O, Davis RP, Zhai L, Hurley TD, Benner SA. Gene duplication can generate “whole gene” and “chimeric gene” paralogs. Plos One. DOI: 10.1371/Journal.Pone.0041175.G004  0.212
2007 Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sánchez-Lozada LG. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. The American Journal of Clinical Nutrition. 86: 899-906. PMID 17921363 DOI: 10.1093/Ajcn/86.4.899  0.208
2022 Jerome CA, Kim HJ, Mojzsis SJ, Benner SA, Biondi E. Catalytic Synthesis of Polyribonucleic Acid on Prebiotic Rock Glasses. Astrobiology. PMID 35588195 DOI: 10.1089/ast.2022.0027  0.202
2021 Kim HJ, Benner SA. Abiotic Synthesis of Nucleoside 5'-Triphosphates with Nickel Borate and Cyclic Trimetaphosphate (CTMP). Astrobiology. PMID 33533695 DOI: 10.1089/ast.2020.2264  0.195
1986 Dunitz JD, Benner SA. Body temperature and the specific heat of water Nature. 324: 418. DOI: 10.1038/324418C0  0.189
1995 Benner SA, Jermann TM, Opitz JG, Stackhouse J, Knecht LJ, Gonnet GH. Uncertainty in ancient phylogenies Nature. 377: 109-110. DOI: 10.1038/377109A0  0.182
2015 Glushakova LG, Sharma N, Hoshika S, Bradley AC, Bradley KM, Yang Z, Benner SA. Detecting respiratory viral RNA using expanded genetic alphabets and self-avoiding DNA Analytical Biochemistry. 489: 62-72. DOI: 10.1016/j.ab.2015.08.015  0.182
1994 Benner SA, Cohen MA, Gonnet GH. Amino acid substitution during functionally constrained divergent evolution of protein sequences. Protein Engineering. 7: 1323-32. PMID 7700864 DOI: 10.1093/Protein/7.11.1323  0.18
2008 Hoshika S, Chen F, Leal NA, Benner SA. Self-Avoiding Molecular Recognition Systems (SAMRS). Nucleic Acids Symposium Series (2004). 129-30. PMID 18776287 DOI: 10.1093/nass/nrn066  0.178
2008 Benner SA, Hoshika S, Sukeda M, Hutter D, Leal N, Yang Z, Chen F. Synthetic biology for improved personalized medicine. Nucleic Acids Symposium Series (2004). 243-4. PMID 18776344 DOI: 10.1093/nass/nrn123  0.177
1992 Benner SA. Predicting de novo the folded structure of proteins Current Opinion in Structural Biology. 2: 402-412. DOI: 10.1016/0959-440X(92)90232-V  0.176
2023 Pham TM, Miffin T, Sun H, Sharp KK, Wang X, Zhu M, Hoshika S, Peterson RJ, Benner SA, Kahn JD, Mathews DH. DNA Structure Design Is Improved Using an Artificially Expanded Alphabet of Base Pairs Including Loop and Mismatch Thermodynamic Parameters. Acs Synthetic Biology. PMID 37671922 DOI: 10.1021/acssynbio.3c00358  0.169
2023 Pham TM, Miffin T, Sun H, Sharp KK, Wang X, Zhu M, Hoshika S, Peterson RJ, Benner SA, Kahn JD, Mathews DH. DNA Structure Design Is Improved Using an Artificially Expanded Alphabet of Base Pairs Including Loop and Mismatch Thermodynamic Parameters. Biorxiv : the Preprint Server For Biology. PMID 37333404 DOI: 10.1101/2023.06.06.543917  0.166
2023 Yaren O, McCarter J, Morris AR, Bradley KM, Karalkar NB, McLendon DC, Kim D, Eastmond BH, Burkett-Cadena ND, Alto BW, Benner SA. Multiplex Surveillance Kit Using Sweetened Solid Support to Detect Arboviruses Isothermally in Mosquito Saliva from the Field. Analytical Chemistry. PMID 37390024 DOI: 10.1021/acs.analchem.3c01735  0.166
2011 Benner SA. Comment on "A bacterium that can grow by using arsenic instead of phosphorus". Science (New York, N.Y.). 332: 1149; author reply 1. PMID 21622712 DOI: 10.1126/science.1201304  0.155
1997 Benner SA, Cannarozzi G, Gerloff D, Turcotte M, Chelvanayagam G. Bona fide predictions of protein secondary structure using transparent analyses of multiple sequence alignments Chemical Reviews. 97: 2725-2843.  0.153
2010 JENNY TF, BENNER SA. ChemInform Abstract: Carbocyclic Analogues of Nucleosides. Part 4. Preparation of Enantiomerically Pure Analogues of Purine Nucleosides for the Synthesis of Sulfone-Linked Oligonucleotide Analogues. Cheminform. 24: no-no. DOI: 10.1002/chin.199332252  0.151
1987 Nambiar KP, Stackhouse J, Presnell SR, Benner SA. Expression of bovine pancreatic ribonuclease A in Escherichia coli European Journal of Biochemistry. 163: 67-71. PMID 3545826 DOI: 10.1111/j.1432-1033.1987.tb10737.x  0.151
2010 VOEGEL JJ, BENNER SA. ChemInform Abstract: Synthesis and Characterization of Non-Standard Nucleosides and Nucleotides Bearing the Acceptor-Donor-Donor Pyrimidine Analogue 6- Amino-3-methylpyrazin-2(1H)-one. Cheminform. 28: no-no. DOI: 10.1002/chin.199706214  0.15
2011 Benner SA, Chen F, Yang Z. Synthetic Biology, Tinkering Biology, and Artificial Biology: A Perspective from Chemistry Chemical Synthetic Biology. 69-106. DOI: 10.1002/9780470977873.ch3  0.15
1994 Boix E, Nogués MV, Schein CH, Benner SA, Cuchillo CM. Reverse Transphosphorylation by Ribonuclease A Needs an Intact p2-binding Site: Point mutations at LYS-7 and ARG-10 alter the catalytic properties of the enzyme Journal of Biological Chemistry. 269: 2529-2534. PMID 8300580  0.148
1995 Benner SA. Predicting the conformation of proteins from sequences. Progress and future progress Journal of Molecular Recognition : Jmr. 8: 9-28. PMID 7598957  0.142
2015 Yaren O, Benner SA. Restriction enzymes cleave DNA immobilized on micron-sized diamond crystallites Diamond and Related Materials. 52: 18-24. DOI: 10.1016/j.diamond.2014.11.013  0.139
1982 Benner SA. The stereoselectivity of alcohol dehydrogenases: A sterochemical imperative? Experientia. 38: 633-637. PMID 7047206 DOI: 10.1007/BF02327092  0.136
2020 Špaček J, Karalkar N, Fojta M, Wang J, Benner SA. Electrochemical Reduction and Oxidation of Eight Unnatural 2'-Deoxynucleosides at a Pyrolytic Graphite Electrode. Electrochimica Acta. 362. PMID 33087943 DOI: 10.1016/j.electacta.2020.137210  0.132
2022 Laos R, Benner S. Fluorinated oil-surfactant mixtures with the density of water: Artificial cells for synthetic biology. Plos One. 17: e0252361. PMID 35051170 DOI: 10.1371/journal.pone.0252361  0.132
1981 Benner SA. Diphenylphosphinodithioic acid: A reagent for the conversion of nitriles to thioamides Tetrahedron Letters. 22: 1851-1854. DOI: 10.1016/S0040-4039(01)90459-9  0.128
2010 Benner SA. Defining life. Astrobiology. 10: 1021-30. PMID 21162682 DOI: 10.1089/ast.2010.0524  0.122
2015 Benner SA. Foreword Aptamers Selected by Cell-Selex For Theranostics. v-vii. DOI: 10.1007/978-3-662-46226-3  0.12
2024 Wang B, Pan X, Teng IT, Li X, Kobeissy F, Wu ZY, Zhu J, Cai G, Yan H, Yan X, Liang M, Yu F, Lu J, Yang Z, Biondi E, ... ... Benner SA, et al. Functional Selection of Tau Oligomerization-Inhibiting Aptamers. Angewandte Chemie (International Ed. in English). e202402007. PMID 38407551 DOI: 10.1002/anie.202402007  0.12
2024 Kim D, DeBriere TJ, Eastmond BH, Alomar AA, Yaren O, McCarter J, Bradley KM, Benner SA, Alto BW, Burkett-Cadena ND. Rapid detection of West Nile and Dengue viruses from mosquito saliva by loop-mediated isothermal amplification and displaced probes. Plos One. 19: e0298805. PMID 38394282 DOI: 10.1371/journal.pone.0298805  0.12
2024 Aiyer S, Baldwin PR, Tan SM, Shan Z, Oh J, Mehrani A, Bowman ME, Louie G, Passos DO, Đorđević-Marquardt S, Mietzsch M, Hull JA, Hoshika S, Barad BA, Grotjahn DA, ... ... Benner SA, et al. Overcoming resolution attenuation during tilted cryo-EM data collection. Nature Communications. 15: 389. PMID 38195598 DOI: 10.1038/s41467-023-44555-7  0.119
1992 Benner SA. Predicting de novo the folded structure of proteins Current Biology. 2: 376. DOI: 10.1016/0960-9822(92)90077-N  0.117
2016 Benner SA. Unusual Hydrogen Bonding Patterns and the Role of the Backbone in Nucleic Acid Information Transfer. Acs Central Science. 2: 882-884. PMID 28058276 DOI: 10.1021/acscentsci.6b00344  0.116
2021 Carn D, Lanaspa MA, Benner SA, Andrews P, Dudley R, Andres-Hernando A, Tolan DR, Johnson RJ. The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis. Alcoholism, Clinical and Experimental Research. PMID 34120350 DOI: 10.1111/acer.14655  0.114
2021 Yaren O, McCarter J, Phadke N, Bradley KM, Overton B, Yang Z, Ranade S, Patil K, Bangale R, Benner SA. Ultra-rapid detection of SARS-CoV-2 in public workspace environments. Plos One. 16: e0240524. PMID 33626039 DOI: 10.1371/journal.pone.0240524  0.114
1989 BENNER SA. ChemInform Abstract: Enzyme Kinetics and Molecular Evolution Cheminform. 20. DOI: 10.1002/chin.198943346  0.112
2012 Benner SA. Use of codon models in molecular dating and functional analysis Codon Evolution: Mechanisms and Models. DOI: 10.1093/acprof:osobl/9780199601165.003.0010  0.112
1996 Gonnet GH, Benner SA. Probabilistic ancestral sequences and multiple alignments Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 1097: 380-391.  0.111
2010 Johnson RJ, Andrews P, Benner SA, Oliver W. Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene. Transactions of the American Clinical and Climatological Association. 121: 295-305; discussion . PMID 20697570  0.108
2010 JENNY TF, HORLACHER J, PREVISANI N, BENNER SA. ChemInform Abstract: Carbocyclic Analogues of Nucleosides. Part 2. Synthesis of 2′,3′- Dideoxy-5′-homonucleoside Analogues. Cheminform. 24: no-no. DOI: 10.1002/chin.199303267  0.108
2010 HUANG Z, SCHNEIDER KC, BENNER SA. ChemInform Abstract: Building Blocks for Oligonucleotide Analogues with Dimethylene Sulfide, Sulfoxide, and Sulfone Group Replacing Phosphodiester Linkages. Cheminform. 22: no-no. DOI: 10.1002/chin.199144291  0.107
2010 JENNY TF, BENNER SA. ChemInform Abstract: Efficient Regioselective Synthesis of Guanosine Analogs. Cheminform. 24: no-no. DOI: 10.1002/chin.199312256  0.106
2010 HUANG Z, SCHNEIDER KC, BENNER SA. ChemInform Abstract: Oligonucleotide Analogues with Dimethylenesulfide, -sulfoxide, and - sulfone Groups Replacing Phosphodiester Linkages Cheminform. 25: no-no. DOI: 10.1002/chin.199410307  0.105
2022 Špaček J, Benner SA. Agnostic Life Finder (ALF) for Large-Scale Screening of Martian Life During Refueling. Astrobiology. PMID 35796703 DOI: 10.1089/ast.2021.0070  0.105
2010 Benner SA, Geroff DL, Rozzell JD. Protein structure prediction. Science (New York, N.Y.). 274: 1448b-9b. PMID 17816993 DOI: 10.1126/science.274.5292.1448b  0.104
1996 Benner SA, Geroff DL, Rozzell JD. Protein structure prediction [2] Science. 274: 1448-1449. PMID 8966608  0.104
1996 Benner SA, Geroff DL, David Rozzell J. Protein Structure Prediction Science. 274: 1447b-1451. DOI: 10.1126/science.274.5292.1447b  0.104
1983 NAMBIAR KP, STAUFFER DM, KOLODZIEJ PA, BENNER SA. ChemInform Abstract: A MECHANISTIC BASIS FOR THE STEREOSELECTIVITY OF ENZYMIC TRANSFER OF HYDROGEN FROM NICOTINAMIDE COFACTORS Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198350328  0.103
2023 Aiyer S, Baldwin PR, Tan SM, Shan Z, Oh J, Mehrani A, Bowman ME, Louie G, Passos DO, Đorđević-Marquardt S, Mietzsch M, Hull JA, Hoshika S, Barad BA, Grotjahn DA, ... ... Benner SA, et al. Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection. Biorxiv : the Preprint Server For Biology. PMID 37503021 DOI: 10.1101/2023.07.14.548955  0.103
1990 Schneider KC, Benner SA. Building blocks for oligonucleotide analogs with dimethylene-sulfide, -sulfoxide, and -sulfone groups replacing phosphodiester linkages Tetrahedron Letters. 31: 335-338. DOI: 10.1016/S0040-4039(00)94548-9  0.102
1996 Benner SA. Catalysis: The omnipresent phenomenon Faseb Journal. 10: A968.  0.102
2022 Biţă A, Scorei IR, Bălşeanu TA, Ciocîlteu MV, Bejenaru C, Radu A, Bejenaru LE, Rău G, Mogoşanu GD, Neamţu J, Benner SA. New Insights into Boron Essentiality in Humans and Animals. International Journal of Molecular Sciences. 23. PMID 36012416 DOI: 10.3390/ijms23169147  0.1
2010 HUANG Z, BENNER SA. ChemInform Abstract: Functionalization of Nucleoside Analogues: Regiospecific Conversion of 4′′-Hydroxyl Groups to Thioesters and Deoxygenation of 3′-Hydroxyl Groups. Cheminform. 29: no-no. DOI: 10.1002/chin.199836268  0.098
2023 Biţă A, Scorei IR, Ciocîlteu MV, Nicolaescu OE, Pîrvu AS, Bejenaru LE, Rău G, Bejenaru C, Radu A, Neamţu J, Mogoşanu GD, Benner SA. Nicotinamide Riboside, a Promising Vitamin B Derivative for Healthy Aging and Longevity: Current Research and Perspectives. Molecules (Basel, Switzerland). 28. PMID 37630330 DOI: 10.3390/molecules28166078  0.098
1988 GLASFELD A, ZBINDEN P, DOBLER M, BENNER SA, DUNITZ JD. ChemInform Abstract: Crystal Structures of Two Simple N-Substituted Dihydronicotinamides: Possible Implications for Stereoelectronic Arguments in Enzymology Cheminform. 19. DOI: 10.1002/chin.198846062  0.098
1981 BENNER SA. ChemInform Abstract: DIPHENYLPHOSPHINODITHIOIC ACID: A REAGENT FOR THE CONVERSION OF NITRILES TO THIOAMIDES Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198136189  0.096
2010 KODRA JT, BENNER SA. ChemInform Abstract: Synthesis of an N-Alkyl Derivative of 2′-Deoxyisoguanosine. Cheminform. 28: no-no. DOI: 10.1002/chin.199751249  0.095
1997 Kodra JT, Benner SA. Synthesis of an N-Alkyl Derivative of 2′-Deoxywoguanosine Synlett. 1997: 939-940.  0.092
1981 BENNER SA, MORTON TH. ChemInform Abstract: ANALOGS FOR ACETOACETATE AS AN ENZYME SUBSTRATE. STEREOCHEMICAL PREFERENCES Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198122159  0.089
1981 BENNER SA. ChemInform Abstract: MECHANISM OF THE REACTION OF DIPHENYLPHOSPHINODITHIOIC ACID WITH NITRILES Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198136190  0.089
2013 Benner SA. Synthesis as a Route to Knowledge Biological Theory. 8: 357-367. DOI: 10.1007/s13752-013-0142-y  0.086
2010 ARSLAN T, HERRADON B, SCHWEIZER BW, BENNER SA. ChemInform Abstract: Determination of the Absolute Configuration of Dimethyl (2S,3S)-2- Allyl-3-hydroxyglutarate: A Chiral Building Block for Preparing Branched-Chain Nucleoside Analogues. Cheminform. 25: no-no. DOI: 10.1002/chin.199411104  0.086
2010 VOEGEL JJ, ALTORFER MM, BENNER SA. ChemInform Abstract: Donor-Acceptor-Acceptor Purine Analogue: Transformation of 5-Aza-7- deaza-1H-isoguanine (= 4-Aminoimidazo(1,2-a)-1,3,5-triazin-2(1H)-one) to 2′-Deoxy-5-aza-7-deaza-isoguanosine Using Purine Nucleoside Phosphorylase. Cheminform. 24: no-no. DOI: 10.1002/chin.199348269  0.085
2001 Benner SA. Natural progression. Nature. 409: 459. PMID 11206523 DOI: 10.1038/35054149  0.085
1981 Benner SA, Maggio JE, Simmons HE. Rearrangement of a geometrically restricted triepoxide to the first topologically nonplanar molecule: a reaction path elucidated by using oxygen isotope effects on carbon-13 chemical shifts Journal of the American Chemical Society. 103: 1581-1582. DOI: 10.1021/ja00396a058  0.084
1981 Benner SA. Mechanism of the reaction of diphenylphosphinodithioic acid with nitriles Tetrahedron Letters. 22: 1855-1858. DOI: 10.1016/S0040-4039(01)90460-5  0.082
2010 JENNY TF, PREVISANI N, BENNER SA. ChemInform Abstract: Carbocyclic Analogs of Nucleosides, e.g. (III), via Modified Mitsunobu Reactions. Cheminform. 23: no-no. DOI: 10.1002/chin.199230235  0.078
2010 HUANG Z, BENNER SA. ChemInform Abstract: Selective Protection and Deprotection Procedures for Thiol and Hydroxyl Group. Cheminform. 25: no-no. DOI: 10.1002/chin.199415108  0.075
2020 Benner SA, Bell EA, Biondi E, Brasser R, Carell T, Kim H, Mojzsis SJ, Omran A, Pasek MA, Trail D. Front Cover: When Did Life Likely Emerge on Earth in an RNA‐First Process? (ChemSystemsChem 2/2020) Chemsystemschem. 2. DOI: 10.1002/syst.202000010  0.075
2020 Benner SA, Bell EA, Biondi E, Brasser R, Carell T, Kim H, Mojzsis SJ, Omran A, Pasek MA, Trail D. When Did Life Likely Emerge on Earth in an RNA‐First Process? Chemsystemschem. 2. DOI: 10.1002/syst.201900035  0.074
2010 Benner SA. Chemistry, life, and the search for aliens Proceedings of Spie - the International Society For Optical Engineering. 7819. DOI: 10.1117/12.866981  0.074
2014 Benner SA. Paradoxes in the origin of life. Origins of Life and Evolution of the Biosphere : the Journal of the International Society For the Study of the Origin of Life. 44: 339-43. PMID 25608919 DOI: 10.1007/s11084-014-9379-0  0.07
2018 Benner SA. Prebiotic plausibility and networks of paradox-resolving independent models. Nature Communications. 9: 5173. PMID 30538230 DOI: 10.1038/s41467-018-07274-y  0.068
2018 Benner S, Corey EJ. Frank Henry Westheimer. 15 January 1912—14 April 2007 Biographical Memoirs of Fellows of the Royal Society. 65: 469-480. DOI: 10.1098/Rsbm.2018.0009  0.065
2011 Benner SA, Yang Z, Chen F. Synthetic biology, tinkering biology, and artificial biology. What are we learning? Comptes Rendus Chimie. 14: 372-387. DOI: 10.1016/j.crci.2010.06.013  0.065
1981 BENNER SA, ROZZELL JDJ, MORTON TH. ChemInform Abstract: STEREOSPECIFICITY AND STEREOCHEMICAL INFIDELITY OF ACETOACETATE DECARBOXYLASE (AAD) Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198122160  0.057
2015 Benner S. Alien life – not necessarily as we know it New Scientist. 228: 28-29. DOI: 10.1016/S0262-4079(15)31662-6  0.057
1981 POLAVARAPU PL, NAFIE LA, BENNER SA, MORTON TH. ChemInform Abstract: OPTICAL ACTIVITY DUE TO ISOTOPIC SUBSTITUTION. VIBRATIONAL CIRCULAR DICHROISM AND THE ABSOLUTE CONFIGURATIONS OF α-DEUTERATED CYCLOHEXANONES Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198150074  0.054
2017 Benner SA. Detecting Darwinism from Molecules in the Enceladus Plumes, Jupiter's Moons, and Other Planetary Water Lagoons. Astrobiology. PMID 28665680 DOI: 10.1089/ast.2016.1611  0.05
2008 Benner SA. The early days of paleogenetics: Connecting molecules to the planet Ancestral Sequence Reconstruction. DOI: 10.1093/acprof:oso/9780199299188.003.0001  0.047
1997 Stead WW, Olsen AJ, Benner SA, Blackwelder M, Cooperstock L, Paton JA, Russell FK, Van Hine P. The IAIMS--an essential infrastructure for increasing the competitiveness of health care practices Journal of the American Medical Informatics Association : Jamia. 4: S73-76. PMID 9067890  0.039
2008 Borg LE, Des Marais DJ, Beaty DW, Aharonson O, Benner SA, Bogard DD, Bridges JC, Budney CJ, Calvin WN, Clark BC, Eigenbrode JL, Grady MM, Head JW, Hemming SR, Hinners NW, et al. Science priorities for Mars sample return Astrobiology. 8: 489-535. PMID 18688946 DOI: 10.1089/ast.2008.0759  0.029
1999 DeMario MD, Ratain MJ, Vogelzang NJ, Mani S, Vokes EE, Fleming GF, Melton K, Johnson S, Benner S, Lebwohl D. A phase I study of oral uracil/ftorafur (UFT) plus leucovorin and bis-acetato-ammine-dichloro-cyclohexylamine-platinum IV (JM-216) each given over 14 days every 28 days. Cancer Chemotherapy and Pharmacology. 43: 385-8. PMID 10100593 DOI: 10.1007/s002800050911  0.027
1995 Benner SA, Jermann TM, Opitz JG, Stackhouse J, Knecht LJ, Gonnet GH. Uncertainty in ancient phylogenies [7] Nature. 377: 109-110.  0.019
1999 Klaassen U, Lang S, Borquez D, Oberhoff C, Benner S, Harstrick A, Seeber S. Phase I/II trial of oral UFT/Leucovorin (LV) and paclitaxel (P) in the second line treatment of patients (PTS) with metastatic breast cancer (MBC) European Journal of Cancer. 35: S322-S323. DOI: 10.1016/S0959-8049(99)81710-9  0.016
1999 Mani S, Sciortino D, Samuels B, Arrietta R, Schilsky RL, Vokes EE, Benner S. Phase II trial of uracil/tegafur (UFT) plus leucovorin in patients with advanced biliary carcinoma. Investigational New Drugs. 17: 97-101. PMID 10555128 DOI: 10.1023/A:1006268018519  0.015
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