Thomas W. Muir, Ph.D. - Publications

Affiliations: 
1996-2011 Chemistry Rockefeller University, New York, NY, United States 
 2011- Chemistry Princeton University, Princeton, NJ 
Area:
physiochemical basis of protein function
Website:
https://chemistry.princeton.edu/faculty/muir

212 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Xie Q, Wiedmann MM, Zhao A, Pagan IR, Novick RP, Suga H, Muir TW. Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC. Chemical Communications (Cambridge, England). PMID 32820778 DOI: 10.1039/D0Cc04873A  0.506
2020 McBride MJ, Mashtalir N, Winter EB, Dao HT, Filipovski M, D'Avino AR, Seo HS, Umbreit NT, St Pierre R, Valencia AM, Qian K, Zullow HJ, Jaffe JD, Dhe-Paganon S, Muir TW, et al. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nature Structural & Molecular Biology. PMID 32747783 DOI: 10.1038/S41594-020-0466-9  0.389
2020 Burton AJ, Haugbro M, Gates LA, Bagert JD, Allis CD, Muir TW. In situ chromatin interactomics using a chemical bait and trap approach. Nature Chemistry. 12: 520-527. PMID 32472103 DOI: 10.1038/S41557-020-0474-8  0.401
2020 Diehl KL, Muir TW. Chromatin as a key consumer in the metabolite economy. Nature Chemical Biology. 16: 620-629. PMID 32444835 DOI: 10.1038/S41589-020-0517-X  0.329
2020 Burton AJ, Haugbro M, Parisi E, Muir TW. Live-cell protein engineering with an ultra-short split intein. Proceedings of the National Academy of Sciences of the United States of America. 117: 12041-12049. PMID 32424098 DOI: 10.1073/Pnas.2003613117  0.475
2020 Kwon M, Park K, Hyun K, Lee JH, Zhou L, Cho YW, Ge K, Skalnik DG, Muir TW, Kim J. H2B ubiquitylation enhances H3K4 methylation activities of human KMT2 family complexes. Nucleic Acids Research. PMID 32365172 DOI: 10.1093/Nar/Gkaa317  0.351
2020 Lin X, Leicher R, Ge E, Reynolds MJ, Walz T, Muir T, Liu S, Zhang B. Coarse-Grained Modeling of PRC2-Mediated Inter-Nucleosomal Interactions Biophysical Journal. 118: 76a. DOI: 10.1016/J.Bpj.2019.11.588  0.749
2020 Leicher R, Ge E, Lin X, Reynolds MJ, Walz T, Zhang B, Muir T, Liu S. Single-Molecule Investigation of PRC2 Non-Adjacent Nucleosome Bridging Biophysical Journal. 118: 380a. DOI: 10.1016/J.Bpj.2019.11.2170  0.752
2019 Wan L, Chong S, Xuan F, Liang A, Cui X, Gates L, Carroll TS, Li Y, Feng L, Chen G, Wang SP, Ortiz MV, Daley SK, Wang X, Xuan H, ... ... Muir TW, et al. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature. PMID 31853060 DOI: 10.1038/S41586-019-1842-7  0.391
2019 Murawska M, Schauer T, Matsuda A, Wilson MD, Pysik T, Wojcik F, Muir TW, Hiraoka Y, Straub T, Ladurner AG. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Molecular Cell. PMID 31837996 DOI: 10.1016/J.Molcel.2019.11.016  0.346
2019 Dao HT, Dul BE, Dann GP, Liszczak GP, Muir TW. A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing. Nature Chemical Biology. PMID 31819269 DOI: 10.1038/S41589-019-0413-4  0.362
2019 Thompson RE, Muir TW. Chemoenzymatic Semisynthesis of Proteins. Chemical Reviews. PMID 31774265 DOI: 10.1021/Acs.Chemrev.9B00450  0.371
2019 Albig C, Wang C, Dann GP, Wojcik F, Schauer T, Krause S, Maenner S, Cai W, Li Y, Girton J, Muir TW, Johansen J, Johansen KM, Becker PB, Regnard C. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Nature Communications. 10: 5343. PMID 31767855 DOI: 10.1038/S41467-019-13174-6  0.39
2019 Valencia AM, Collings CK, Dao HT, St Pierre R, Cheng YC, Huang J, Sun ZY, Seo HS, Mashtalir N, Comstock DE, Bolonduro O, Vangos NE, Yeoh ZC, Dornon MK, Hermawan C, ... ... Muir TW, et al. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. PMID 31759698 DOI: 10.1016/J.Cell.2019.10.044  0.334
2019 Diehl KL, Ge EJ, Weinberg DN, Jani KS, Allis CD, Muir TW. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611394 DOI: 10.1073/Pnas.1911775116  0.776
2019 Ge E, Jani KS, Diehl KL, Mueller MM, Muir TW. Nucleation and propagation of heterochromatin by the histone methyltransferase PRC2: geometric constraints and impact of the regulatory subunit JARID2. Journal of the American Chemical Society. PMID 31479253 DOI: 10.1021/Jacs.9B02321  0.794
2019 Gramespacher JA, Burton AJ, Guerra LF, Muir TW. Proximity Induced Splicing Utilizing Caged Split Inteins. Journal of the American Chemical Society. PMID 31418547 DOI: 10.1021/Jacs.9B05721  0.434
2019 Thompson RE, Stevens AJ, Muir TW. Protein engineering through tandem transamidation. Nature Chemistry. PMID 31263208 DOI: 10.1038/S41557-019-0281-2  0.475
2019 Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF. Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization. Cell. PMID 31104845 DOI: 10.1016/J.Cell.2019.04.028  0.351
2019 Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nature Communications. 10: 2146. PMID 31086175 DOI: 10.1038/S41467-019-09981-6  0.375
2019 Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Müller MM, Lewis PW, Muir TW. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America. PMID 30967505 DOI: 10.1073/Pnas.1819029116  0.787
2019 Nacev BA, Feng L, Bagert JD, Lemiesz AE, Gao J, Soshnev AA, Kundra R, Schultz N, Muir TW, Allis CD. The expanding landscape of 'oncohistone' mutations in human cancers. Nature. PMID 30894748 DOI: 10.1038/S41586-019-1038-1  0.325
2019 Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, ... ... Muir TW, et al. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. PMID 30867594 DOI: 10.1038/S41586-019-1024-7  0.332
2019 Xie Q, Zhao A, Jeffrey PD, Kim MK, Bassler BL, Stone HA, Novick RP, Muir TW. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chemical Biology. PMID 30773482 DOI: 10.1016/J.Chembiol.2019.01.006  0.537
2018 Jeon J, McGinty RK, Muir TW, Kim JA, Kim J. Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation. Nucleic Acids Research. PMID 30325428 DOI: 10.1093/Nar/Gky920  0.339
2018 Stevens AJ, Sekar G, Gramespacher JA, Cowburn D, Muir TW. An Atypical Mechanism of Split Intein Molecular Recognition and Folding. Journal of the American Chemical Society. PMID 30156841 DOI: 10.1021/Jacs.8B07334  0.449
2018 Liszczak GP, Muir TW. Nucleic acid-barcoding technologies: converting DNA sequencing into a broad-spectrum molecular counter. Angewandte Chemie (International Ed. in English). PMID 30153374 DOI: 10.1002/Anie.201808956  0.311
2018 Liszczak G, Diehl KL, Dann GP, Muir TW. Acetylation blocks DNA damage-induced chromatin ADP-ribosylation. Nature Chemical Biology. PMID 30013063 DOI: 10.1038/S41589-018-0097-1  0.337
2018 Wojcik F, Dann GP, Beh LY, Debelouchina GT, Hofmann R, Muir TW. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nature Communications. 9: 1394. PMID 29643390 DOI: 10.1038/S41467-018-03895-5  0.364
2018 Bos J, Muir TW. A Chemical Probe for Protein Crotonylation. Journal of the American Chemical Society. PMID 29584949 DOI: 10.1021/Jacs.7B13141  0.443
2018 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, ... ... Muir TW, et al. How many human proteoforms are there? Nature Chemical Biology. 14: 206-214. PMID 29443976 DOI: 10.1038/Nchembio.2576  0.57
2018 Jenness C, Giunta S, Müller MM, Kimura H, Muir TW, Funabiki H. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. Proceedings of the National Academy of Sciences of the United States of America. PMID 29339483 DOI: 10.1073/Pnas.1717509115  0.353
2017 Debelouchina GT, Muir TW. A molecular engineering toolbox for the structural biologist. Quarterly Reviews of Biophysics. 50: e7. PMID 29233219 DOI: 10.1017/S0033583517000051  0.376
2017 Gramespacher JA, Stevens AJ, Thompson RE, Muir TW. Improved Protein Splicing Using Embedded Split Inteins. Protein Science : a Publication of the Protein Society. PMID 29226478 DOI: 10.1002/Pro.3357  0.414
2017 Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nature Structural & Molecular Biology. PMID 29058709 DOI: 10.1038/Nsmb.3487  0.783
2017 Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Nature Chemical Biology. PMID 28805803 DOI: 10.1038/Nchembio.2453  0.765
2017 Dann GP, Liszczak G, Bagert JD, Müller MM, Nguyen UTT, Wojcik F, Brown ZZ, Bos J, Panchenko T, Pihl R, Pollock SB, Diehl KL, Allis CD, Muir TW. ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference. Nature. PMID 28767641 DOI: 10.1038/Nature23671  0.633
2017 Stevens AJ, Sekar G, Shah NH, Mostafavi AZ, Cowburn D, Muir TW. A promiscuous split intein with expanded protein engineering applications. Proceedings of the National Academy of Sciences of the United States of America. PMID 28739907 DOI: 10.1073/Pnas.1701083114  0.661
2017 David Y, Muir TW. Emerging chemistry strategies for engineering native chromatin. Journal of the American Chemical Society. PMID 28635271 DOI: 10.1021/Jacs.7B03430  0.717
2017 Gramespacher JA, Stevens AJ, Nguyen DP, Chin JW, Muir TW. Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis. Journal of the American Chemical Society. PMID 28562027 DOI: 10.1021/Jacs.7B02618  0.336
2017 Liszczak GP, Brown ZZ, Kim SH, Oslund RC, David Y, Muir TW. Genomic targeting of epigenetic probes using a chemically tailored Cas9 system. Proceedings of the National Academy of Sciences of the United States of America. PMID 28069948 DOI: 10.1073/Pnas.1615723114  0.738
2017 Wang B, Zhao A, Xie Q, Olinares PD, Chait BT, Novick RP, Muir TW. Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence. Cell Chemical Biology. 24: 76-86. PMID 28065658 DOI: 10.1016/J.Chembiol.2016.12.008  0.523
2016 Debelouchina GT, Gerecht K, Muir TW. Ubiquitin utilizes an acidic surface patch to alter chromatin structure. Nature Chemical Biology. PMID 27870837 DOI: 10.1038/Nchembio.2235  0.397
2016 Frutos S, Jordan JB, Bio MM, Muir TW, Thiel OR, Vila-Perelló M. Access to site-specific Fc-cRGD peptide conjugates through streamlined expressed protein ligation. Organic & Biomolecular Chemistry. PMID 27722696 DOI: 10.1039/C6Ob01833E  0.35
2016 Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, ... ... Muir TW, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science (New York, N.Y.). 352: 844-9. PMID 27174990 DOI: 10.1126/Science.Aac7272  0.305
2016 Stevens AJ, Brown ZZ, Shah NH, Sekar G, Cowburn D, Muir TW. Design of a Split Intein with Exceptional Protein Splicing Activity. Journal of the American Chemical Society. PMID 26854538 DOI: 10.1021/Jacs.5B13528  0.67
2016 Zhou L, Holt MT, Ohashi N, Zhao A, Müller MM, Wang B, Muir TW. Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nature Communications. 7: 10589. PMID 26830124 DOI: 10.1038/Ncomms10589  0.613
2016 Müller MM, Fierz B, Bittova L, Liszczak G, Muir TW. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nature Chemical Biology. PMID 26807716 DOI: 10.1038/Nchembio.2008  0.684
2015 Beh LY, Müller MM, Muir TW, Kaplan N, Landweber LF. DNA-guided establishment of nucleosome patterns within coding regions of a eukaryotic genome. Genome Research. 25: 1727-38. PMID 26330564 DOI: 10.1101/Gr.188516.114  0.309
2015 Wang B, Zhao A, Novick RP, Muir TW. Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence. Proceedings of the National Academy of Sciences of the United States of America. 112: 10679-84. PMID 26261307 DOI: 10.1073/Pnas.1506030112  0.543
2015 Holt MT, David Y, Pollock S, Tang Z, Jeon J, Kim J, Roeder RG, Muir TW. Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. Proceedings of the National Academy of Sciences of the United States of America. PMID 26240340 DOI: 10.1073/Pnas.1504483112  0.786
2015 David Y, Vila-Perelló M, Verma S, Muir TW. Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins. Nature Chemistry. 7: 394-402. PMID 25901817 DOI: 10.1038/Nchem.2224  0.808
2015 Brown ZZ, Müller MM, Kong HE, Lewis PW, Muir TW. Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin. Angewandte Chemie (International Ed. in English). 54: 6457-61. PMID 25873363 DOI: 10.1002/Anie.201500085  0.794
2015 Johnson JG, Wang B, Debelouchina GT, Novick RP, Muir TW. Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus. Chembiochem : a European Journal of Chemical Biology. 16: 1093-100. PMID 25801678 DOI: 10.1002/Cbic.201500006  0.539
2015 Holt M, Muir T. Application of the protein semisynthesis strategy to the generation of modified chromatin. Annual Review of Biochemistry. 84: 265-90. PMID 25784050 DOI: 10.1146/Annurev-Biochem-060614-034429  0.635
2015 Kee JM, Oslund RC, Couvillon AD, Muir TW. A second-generation phosphohistidine analog for production of phosphohistidine antibodies. Organic Letters. 17: 187-9. PMID 25531910 DOI: 10.1021/Ol503320P  0.594
2015 Müller MM, Muir TW. Histones: at the crossroads of peptide and protein chemistry. Chemical Reviews. 115: 2296-349. PMID 25330018 DOI: 10.1021/Cr5003529  0.422
2015 Wang B, Zhao A, Novick RP, Muir TW. Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence Proceedings of the National Academy of Sciences of the United States of America. 112: 10679-10684. DOI: 10.1073/pnas.1506030112  0.427
2014 Brown ZZ, Müller MM, Jain SU, Allis CD, Lewis PW, Muir TW. Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2. Journal of the American Chemical Society. 136: 13498-501. PMID 25180930 DOI: 10.1021/Ja5060934  0.365
2014 Oslund RC, Kee JM, Couvillon AD, Bhatia VN, Perlman DH, Muir TW. A phosphohistidine proteomics strategy based on elucidation of a unique gas-phase phosphopeptide fragmentation mechanism. Journal of the American Chemical Society. 136: 12899-911. PMID 25156620 DOI: 10.1021/Ja507614F  0.609
2014 Nguyen UT, Bittova L, Müller MM, Fierz B, David Y, Houck-Loomis B, Feng V, Dann GP, Muir TW. Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries. Nature Methods. 11: 834-40. PMID 24997861 DOI: 10.1038/Nmeth.3022  0.793
2014 Liu Z, Frutos S, Bick MJ, Vila-Perelló M, Debelouchina GT, Darst SA, Muir TW. Structure of the branched intermediate in protein splicing. Proceedings of the National Academy of Sciences of the United States of America. 111: 8422-7. PMID 24778214 DOI: 10.1073/Pnas.1402942111  0.819
2014 Eryilmaz E, Shah NH, Muir TW, Cowburn D. Structural and dynamical features of inteins and implications on protein splicing. The Journal of Biological Chemistry. 289: 14506-11. PMID 24695731 DOI: 10.1074/Jbc.R113.540302  0.675
2014 Wang B, Zhao A, Novick RP, Muir TW. Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions. Molecular Cell. 53: 929-40. PMID 24656130 DOI: 10.1016/J.Molcel.2014.02.029  0.52
2014 Shah NH, Muir TW. Inteins: Nature's Gift to Protein Chemists. Chemical Science (Royal Society of Chemistry : 2010). 5: 446-461. PMID 24634716 DOI: 10.1039/C3Sc52951G  0.686
2014 Eryilmaz E, Shah NH, Muir TW, Cowburn D. Structural and dynamical features of inteins and implications on protein splicing (Journal of Biological Chemistry (2014) 289 (14506-14511)) Journal of Biological Chemistry. 289: 19278. DOI: 10.1074/Jbc.A113.540302  0.626
2013 Shah NH, Eryilmaz E, Cowburn D, Muir TW. Naturally split inteins assemble through a "capture and collapse" mechanism. Journal of the American Chemical Society. 135: 18673-81. PMID 24236406 DOI: 10.1021/Ja4104364  0.666
2013 Kim DH, Tang Z, Shimada M, Fierz B, Houck-Loomis B, Bar-Dagen M, Lee S, Lee SK, Muir TW, Roeder RG, Lee JW. Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes. Molecular and Cellular Biology. 33: 4936-46. PMID 24126056 DOI: 10.1128/Mcb.00601-13  0.672
2013 Tang Z, Chen WY, Shimada M, Nguyen UT, Kim J, Sun XJ, Sengoku T, McGinty RK, Fernandez JP, Muir TW, Roeder RG. SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell. 154: 297-310. PMID 23870121 DOI: 10.1016/J.Cell.2013.06.027  0.554
2013 Kee JM, Oslund RC, Perlman DH, Muir TW. A pan-specific antibody for direct detection of protein histidine phosphorylation. Nature Chemical Biology. 9: 416-21. PMID 23708076 DOI: 10.1038/Nchembio.1259  0.61
2013 Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (New York, N.Y.). 340: 857-61. PMID 23539183 DOI: 10.1126/Science.1232245  0.335
2013 Shah NH, Eryilmaz E, Cowburn D, Muir TW. Extein residues play an intimate role in the rate-limiting step of protein trans-splicing. Journal of the American Chemical Society. 135: 5839-47. PMID 23506399 DOI: 10.1021/Ja401015P  0.696
2013 Kim J, Kim JA, McGinty RK, Nguyen UT, Muir TW, Allis CD, Roeder RG. The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Molecular Cell. 49: 1121-33. PMID 23453808 DOI: 10.1016/J.Molcel.2013.01.034  0.578
2013 Wu L, Lee SY, Zhou B, Nguyen UT, Muir TW, Tan S, Dou Y. ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes. Molecular Cell. 49: 1108-20. PMID 23453805 DOI: 10.1016/J.Molcel.2013.01.033  0.602
2013 Vila-Perelló M, Liu Z, Shah NH, Willis JA, Idoyaga J, Muir TW. Streamlined expressed protein ligation using split inteins. Journal of the American Chemical Society. 135: 286-92. PMID 23265282 DOI: 10.1021/Ja309126M  0.834
2012 Fierz B, Kilic S, Hieb AR, Luger K, Muir TW. Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis. Journal of the American Chemical Society. 134: 19548-51. PMID 23163596 DOI: 10.1021/Ja308908P  0.706
2012 Shah NH, Dann GP, Vila-Perelló M, Liu Z, Muir TW. Ultrafast protein splicing is common among cyanobacterial split inteins: implications for protein engineering. Journal of the American Chemical Society. 134: 11338-41. PMID 22734434 DOI: 10.1021/Ja303226X  0.819
2012 Whitcomb SJ, Fierz B, McGinty RK, Holt M, Ito T, Muir TW, Allis CD. Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2. The Journal of Biological Chemistry. 287: 23718-25. PMID 22619169 DOI: 10.1074/Jbc.M112.361824  0.753
2012 Brown ZZ, Muir TW. From EPOthilone to EPO: Aa challenge for natural product synthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 7134-5. PMID 22529360 DOI: 10.1073/Pnas.1205667109  0.351
2012 Fierz B, Muir TW. Chromatin as an expansive canvas for chemical biology. Nature Chemical Biology. 8: 417-27. PMID 22510649 DOI: 10.1038/Nchembio.938  0.67
2012 Kee JM, Muir TW. Chasing phosphohistidine, an elusive sibling in the phosphoamino acid family. Acs Chemical Biology. 7: 44-51. PMID 22148577 DOI: 10.1021/Cb200445W  0.607
2012 Geisinger E, George EA, Chen J, Muir TW, Novick RP. Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor (Journal of Biological Chemistry (2012) 283, (8930-8938)) Journal of Biological Chemistry. 287: 18588. DOI: 10.1074/jbc.A112.710227  0.411
2011 Shah NH, Muir TW. Split Inteins: Nature's Protein Ligases. Israel Journal of Chemistry. 51: 854-861. PMID 23620603 DOI: 10.1002/Ijch.201100094  0.671
2011 Janz JM, Ren Y, Looby R, Kazmi MA, Sachdev P, Grunbeck A, Haggis L, Chinnapen D, Lin AY, Seibert C, McMurry T, Carlson KE, Muir TW, Hunt S, Sakmar TP. Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. Journal of the American Chemical Society. 133: 15878-81. PMID 21905700 DOI: 10.1021/Ja206661W  0.318
2011 Nguyen DP, Elliott T, Holt M, Muir TW, Chin JW. Genetically encoded 1,2-aminothiols facilitate rapid and site-specific protein labeling via a bio-orthogonal cyanobenzothiazole condensation. Journal of the American Chemical Society. 133: 11418-21. PMID 21736333 DOI: 10.1021/Ja203111C  0.574
2011 Shah NH, Vila-Perelló M, Muir TW. Kinetic control of one-pot trans-splicing reactions by using a wild-type and designed split intein. Angewandte Chemie (International Ed. in English). 50: 6511-5. PMID 21656885 DOI: 10.1002/Anie.201102909  0.828
2011 Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD. Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell. 145: 692-706. PMID 21596426 DOI: 10.1016/J.Cell.2011.03.053  0.372
2011 Cho JH, Muralidharan V, Vila-Perello M, Raleigh DP, Muir TW, Palmer AG. Tuning protein autoinhibition by domain destabilization. Nature Structural & Molecular Biology. 18: 550-5. PMID 21532593 DOI: 10.1038/Nsmb.2039  0.817
2011 Singla N, Erdjument-Bromage H, Himanen JP, Muir TW, Nikolov DB. A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation. Chemistry & Biology. 18: 361-71. PMID 21439481 DOI: 10.1016/J.Chembiol.2011.01.011  0.336
2011 Allis CD, Muir TW. Spreading chromatin into chemical biology. Chembiochem : a European Journal of Chemical Biology. 12: 264-79. PMID 21243714 DOI: 10.1002/Cbic.201000761  0.332
2011 Fierz B, Chatterjee C, McGinty RK, Bar-Dagan M, Raleigh DP, Muir TW. Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nature Chemical Biology. 7: 113-9. PMID 21196936 DOI: 10.1038/Nchembio.501  0.755
2011 Fierz B, Chatterjee C, McGinty RK, Bar-Dagan M, Raleigh DP, Muir TW. Discrete Mechanisms Govern the Modulation of Chromatin Structure by Ubiquitylation and Acetylation Biophysical Journal. 100: 68a. DOI: 10.1016/J.Bpj.2010.12.570  0.755
2010 Moyle PM, Muir TW. Method for the synthesis of mono-ADP-ribose conjugated peptides. Journal of the American Chemical Society. 132: 15878-80. PMID 20968292 DOI: 10.1021/Ja1064312  0.63
2010 Vila-Perelló M, Muir TW. Biological applications of protein splicing. Cell. 143: 191-200. PMID 20946979 DOI: 10.1016/J.Cell.2010.09.031  0.792
2010 Kee JM, Villani B, Carpenter LR, Muir TW. Development of stable phosphohistidine analogues. Journal of the American Chemical Society. 132: 14327-9. PMID 20879710 DOI: 10.1021/Ja104393T  0.62
2010 Frutos S, Goger M, Giovani B, Cowburn D, Muir TW. Branched intermediate formation stimulates peptide bond cleavage in protein splicing. Nature Chemical Biology. 6: 527-33. PMID 20495572 DOI: 10.1038/Nchembio.371  0.819
2010 Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S, Wilm M, Muir TW, Müller J. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature. 465: 243-7. PMID 20436459 DOI: 10.1038/Nature08966  0.379
2010 Chatterjee C, McGinty RK, Fierz B, Muir TW. Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nature Chemical Biology. 6: 267-9. PMID 20208522 DOI: 10.1038/Nchembio.315  0.767
2010 Chatterjee C, Muir TW. Chemical approaches for studying histone modifications. The Journal of Biological Chemistry. 285: 11045-50. PMID 20147749 DOI: 10.1074/Jbc.R109.080291  0.603
2009 Averette KM, Pratt MR, Yang Y, Bassilian S, Whitelegge JP, Loo JA, Muir TW, Bradley KA. Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent. Plos One. 4: e7913. PMID 19924255 DOI: 10.1371/Journal.Pone.0007913  0.558
2009 McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW. Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. Acs Chemical Biology. 4: 958-68. PMID 19799466 DOI: 10.1021/Cb9002255  0.725
2009 Pratt MR, Sekedat MD, Chiang KP, Muir TW. Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe. Chemistry & Biology. 16: 1001-12. PMID 19778728 DOI: 10.1016/J.Chembiol.2009.07.011  0.543
2009 George Cisar EA, Geisinger E, Muir TW, Novick RP. Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC. Molecular Microbiology. 74: 44-57. PMID 19708918 DOI: 10.1111/J.1365-2958.2009.06849.X  0.521
2009 McGinty RK, Chatterjee C, Muir TW. Semisynthesis of ubiquitylated proteins. Methods in Enzymology. 462: 225-43. PMID 19632477 DOI: 10.1016/S0076-6879(09)62011-5  0.657
2009 Chiang KP, Jensen MS, McGinty RK, Muir TW. A semisynthetic strategy to generate phosphorylated and acetylated histone H2B. Chembiochem : a European Journal of Chemical Biology. 10: 2182-7. PMID 19623598 DOI: 10.1002/Cbic.200900238  0.464
2009 Lockless SW, Muir TW. Traceless protein splicing utilizing evolved split inteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 10999-1004. PMID 19541616 DOI: 10.1073/Pnas.0902964106  0.77
2009 Kim J, Guermah M, McGinty RK, Lee JS, Tang Z, Milne TA, Shilatifard A, Muir TW, Roeder RG. RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell. 137: 459-71. PMID 19410543 DOI: 10.1016/J.Cell.2009.02.027  0.325
2009 Geisinger E, Muir TW, Novick RP. agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides. Proceedings of the National Academy of Sciences of the United States of America. 106: 1216-21. PMID 19147840 DOI: 10.1073/Pnas.0807760106  0.533
2009 Flavell RR, Muir TW. Expressed protein ligation (EPL) in the study of signal transduction, ion conduction, and chromatin biology. Accounts of Chemical Research. 42: 107-16. PMID 18939858 DOI: 10.1021/Ar800129C  0.489
2008 Chiang KP, Muir TW. Systems- and molecular-level elucidation of signaling processes through chemistry. Science Signaling. 1: pe45. PMID 18941136 DOI: 10.1126/Scisignal.142Pe45  0.349
2008 Schwartz EC, Shekhtman A, Dutta K, Pratt MR, Cowburn D, Darst S, Muir TW. A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding. Chemistry & Biology. 15: 1091-103. PMID 18940669 DOI: 10.1016/J.Chembiol.2008.09.008  0.703
2008 Muir TW. Studying protein structure and function using semisynthesis. Biopolymers. 90: 743-50. PMID 18924136 DOI: 10.1002/Bip.21102  0.472
2008 Vila-Perelló M, Hori Y, Ribó M, Muir TW. Activation of protein splicing by protease- or light-triggered O to N acyl migration. Angewandte Chemie (International Ed. in English). 47: 7764-7. PMID 18767096 DOI: 10.1002/Anie.200802502  0.745
2008 Singla N, Himanen JP, Muir TW, Nikolov DB. Toward the semisynthesis of multidomain transmembrane receptors: modification of Eph tyrosine kinases. Protein Science : a Publication of the Protein Society. 17: 1740-7. PMID 18628240 DOI: 10.1110/Ps.035659.108  0.475
2008 Flavell RR, Kothari P, Bar-Dagan M, Synan M, Vallabhajosula S, Friedman JM, Muir TW, Ceccarini G. Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure. Journal of the American Chemical Society. 130: 9106-12. PMID 18570424 DOI: 10.1021/Ja801666Z  0.314
2008 McGinty RK, Kim J, Chatterjee C, Roeder RG, Muir TW. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature. 453: 812-6. PMID 18449190 DOI: 10.1038/Nature06906  0.622
2008 George EA, Novick RP, Muir TW. Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis. Journal of the American Chemical Society. 130: 4914-24. PMID 18335939 DOI: 10.1021/Ja711126E  0.546
2008 Tyszkiewicz AB, Muir TW. Activation of protein splicing with light in yeast. Nature Methods. 5: 303-5. PMID 18272963 DOI: 10.1038/Nmeth.1189  0.436
2008 Geisinger E, George EA, Chen J, Muir TW, Novick RP. Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor. The Journal of Biological Chemistry. 283: 8930-8. PMID 18222919 DOI: 10.1074/Jbc.M710227200  0.552
2008 Ottesen JJ, Bar-Dagan M, Giovani B, Muir TW. An amalgamation of solid phase peptide synthesis and ribosomal peptide synthesis. Biopolymers. 90: 406-14. PMID 17636509 DOI: 10.1002/Bip.20810  0.823
2008 Pratt MR, Muir TW. Synthesis of Large Biological Molecules: Expressed Protein Ligation Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 2: 537-566. DOI: 10.1002/9783527619375.ch10a  0.583
2007 Hahn ME, Pellois JP, Vila-Perelló M, Muir TW. Tunable photoactivation of a post-translationally modified signaling protein and its unmodified counterpart in live cells. Chembiochem : a European Journal of Chemical Biology. 8: 2100-5. PMID 17907120 DOI: 10.1002/Cbic.200700404  0.792
2007 Vila-Perelló M, Pratt MR, Tulin F, Muir TW. Covalent capture of phospho-dependent protein oligomerization by site-specific incorporation of a diazirine photo-cross-linker. Journal of the American Chemical Society. 129: 8068-9. PMID 17567014 DOI: 10.1021/Ja072013J  0.825
2007 Pratt MR, Schwartz EC, Muir TW. Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt. Proceedings of the National Academy of Sciences of the United States of America. 104: 11209-14. PMID 17563385 DOI: 10.1073/Pnas.0700816104  0.763
2007 Chatterjee C, McGinty RK, Pellois JP, Muir TW. Auxiliary-mediated site-specific peptide ubiquitylation. Angewandte Chemie (International Ed. in English). 46: 2814-8. PMID 17366504 DOI: 10.1002/Anie.200605155  0.543
2007 Schwartz EC, Saez L, Young MW, Muir TW. Post-translational enzyme activation in an animal via optimized conditional protein splicing. Nature Chemical Biology. 3: 50-4. PMID 17128262 DOI: 10.1038/Nchembio832  0.655
2006 Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R. Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science (New York, N.Y.). 314: 1004-7. PMID 17095703 DOI: 10.1126/Science.1133415  0.652
2006 Valiyaveetil FI, Sekedat M, MacKinnon R, Muir TW. Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel. Journal of the American Chemical Society. 128: 11591-9. PMID 16939283 DOI: 10.1021/Ja0631955  0.659
2006 Pellois JP, Muir TW. Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't. Current Opinion in Chemical Biology. 10: 487-91. PMID 16935551 DOI: 10.1016/J.Cbpa.2006.08.016  0.453
2006 Muir TW. Chemical biology: cutting out the middle man. Nature. 442: 517-8. PMID 16885971 DOI: 10.1038/442517A  0.385
2006 Muralidharan V, Dutta K, Cho J, Vila-Perello M, Raleigh DP, Cowburn D, Muir TW. Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II. Biochemistry. 45: 8874-84. PMID 16846230 DOI: 10.1021/Bi060590Z  0.786
2006 Muralidharan V, Muir TW. Protein ligation: an enabling technology for the biophysical analysis of proteins. Nature Methods. 3: 429-38. PMID 16721376 DOI: 10.1038/Nmeth886  0.644
2006 Muir T. Posttranslational Modification of Proteins: Expanding Nature's Inventory. By Christopher T. Walsh. Chembiochem. 7: 1623-1624. DOI: 10.1002/Cbic.200600342  0.349
2005 Muir TW. 2005 Irving Sigal Young Investigator Award. Protein Science : a Publication of the Protein Society. 14: 3140-4. PMID 16322585 DOI: 10.1110/Ps.051848105  0.32
2005 Pellois JP, Muir TW. A ligation and photorelease strategy for the temporal and spatial control of protein function in living cells. Angewandte Chemie (International Ed. in English). 44: 5713-7. PMID 16059958 DOI: 10.1002/Anie.200501244  0.305
2005 Shi J, Muir TW. Development of a tandem protein trans-splicing system based on native and engineered split inteins. Journal of the American Chemical Society. 127: 6198-206. PMID 15853324 DOI: 10.1021/Ja042287W  0.437
2005 Hahn ME, Muir TW. Manipulating proteins with chemistry: a cross-section of chemical biology. Trends in Biochemical Sciences. 30: 26-34. PMID 15653323 DOI: 10.1016/J.Tibs.2004.10.010  0.401
2004 Valiyaveetil FI, Sekedat M, Mackinnon R, Muir TW. Glycine as a D-amino acid surrogate in the K(+)-selectivity filter. Proceedings of the National Academy of Sciences of the United States of America. 101: 17045-9. PMID 15563591 DOI: 10.1073/Pnas.0407820101  0.666
2004 Wright JS, Lyon GJ, George EA, Muir TW, Novick RP. Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing. Proceedings of the National Academy of Sciences of the United States of America. 101: 16168-73. PMID 15528279 DOI: 10.1073/Pnas.0404039101  0.686
2004 Hahn ME, Muir TW. Photocontrol of Smad2, a multiphosphorylated cell-signaling protein, through caging of activating phosphoserines. Angewandte Chemie (International Ed. in English). 43: 5800-3. PMID 15523718 DOI: 10.1002/Anie.200461141  0.354
2004 Muralidharan V, Cho J, Trester-Zedlitz M, Kowalik L, Chait BT, Raleigh DP, Muir TW. Domain-specific incorporation of noninvasive optical probes into recombinant proteins. Journal of the American Chemical Society. 126: 14004-12. PMID 15506763 DOI: 10.1021/Ja0466199  0.808
2004 Mootz HD, Blum ES, Muir TW. Activation of an autoregulated protein kinase by conditional protein splicing. Angewandte Chemie (International Ed. in English). 43: 5189-92. PMID 15455415 DOI: 10.1002/Anie.200460941  0.66
2004 Cowburn D, Shekhtman A, Xu R, Ottesen JJ, Muir TW. Segmental isotopic labeling for structural biological applications of NMR. Methods in Molecular Biology (Clifton, N.J.). 278: 47-56. PMID 15317990 DOI: 10.1385/1-59259-809-9:047  0.724
2004 Pellois JP, Hahn ME, Muir TW. Simultaneous triggering of protein activity and fluorescence. Journal of the American Chemical Society. 126: 7170-1. PMID 15186142 DOI: 10.1021/Ja0499142  0.38
2004 Ottesen JJ, Huse M, Sekedat MD, Muir TW. Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase. Biochemistry. 43: 5698-706. PMID 15134444 DOI: 10.1021/Bi0498407  0.704
2004 Valiyaveetil FI, Sekedat M, Muir TW, MacKinnon R. Semisynthesis of a functional K+ channel. Angewandte Chemie (International Ed. in English). 43: 2504-7. PMID 15127436 DOI: 10.1002/Anie.200453849  0.644
2004 Romanelli A, Shekhtman A, Cowburn D, Muir TW. Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein-intein junction. Proceedings of the National Academy of Sciences of the United States of America. 101: 6397-402. PMID 15087498 DOI: 10.1073/Pnas.0306616101  0.44
2003 Lyon GJ, Muir TW. Chemical signaling among bacteria and its inhibition. Chemistry & Biology. 10: 1007-21. PMID 14652068 DOI: 10.1016/J.Chembiol.2003.11.003  0.592
2003 Wilson KA, Kalkum M, Ottesen J, Yuzenkova J, Chait BT, Landick R, Muir T, Severinov K, Darst SA. Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail. Journal of the American Chemical Society. 125: 12475-83. PMID 14531691 DOI: 10.1021/Ja036756Q  0.705
2003 Schwartz EC, Muir TW, Tyszkiewicz AB. "The splice is right": how protein splicing is opening new doors in protein science. Chemical Communications (Cambridge, England). 2087-90. PMID 13678154 DOI: 10.1039/B304989M  0.649
2003 Mootz HD, Blum ES, Tyszkiewicz AB, Muir TW. Conditional protein splicing: a new tool to control protein structure and function in vitro and in vivo. Journal of the American Chemical Society. 125: 10561-9. PMID 12940738 DOI: 10.1021/Ja0362813  0.699
2003 Giriat I, Muir TW. Protein semi-synthesis in living cells. Journal of the American Chemical Society. 125: 7180-1. PMID 12797783 DOI: 10.1021/Ja034736I  0.821
2003 Muir TW. Semisynthesis of proteins by expressed protein ligation. Annual Review of Biochemistry. 72: 249-89. PMID 12626339 DOI: 10.1146/Annurev.Biochem.72.121801.161900  0.46
2003 Trester-Zedlitz M, Kamada K, Burley SK, Fenyö D, Chait BT, Muir TW. A modular cross-linking approach for exploring protein interactions. Journal of the American Chemical Society. 125: 2416-25. PMID 12603129 DOI: 10.1021/Ja026917A  0.801
2003 Miller JS, Dudkin VY, Lyon GJ, Muir TW, Danishefsky SJ. Toward fully synthetic N-linked glycoproteins. Angewandte Chemie (International Ed. in English). 42: 431-4. PMID 12569509 DOI: 10.1002/Anie.200390131  0.576
2002 Muir TW, McGinty R, Pratt M, Chatterjee C, Schwartz E. Making and Breaking Ubiquitin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4113. PMID 29430986 DOI: 10.1096/Fasebj.22.1_Supplement.411.3  0.818
2002 Hofmann RM, Muir TW. Recent advances in the application of expressed protein ligation to protein engineering. Current Opinion in Biotechnology. 13: 297-303. PMID 12323349 DOI: 10.1016/S0958-1669(02)00326-9  0.428
2002 Valiyaveetil FI, MacKinnon R, Muir TW. Semisynthesis and folding of the potassium channel KcsA. Journal of the American Chemical Society. 124: 9113-20. PMID 12149015 DOI: 10.1021/Ja0266722  0.745
2002 Mootz HD, Muir TW. Protein splicing triggered by a small molecule. Journal of the American Chemical Society. 124: 9044-5. PMID 12148996 DOI: 10.1021/Ja026769O  0.668
2002 Lyon GJ, Wright JS, Muir TW, Novick RP. Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry. 41: 10095-104. PMID 12146974 DOI: 10.1021/Bi026049U  0.709
2002 Camarero JA, Shekhtman A, Campbell EA, Chlenov M, Gruber TM, Bryant DA, Darst SA, Cowburn D, Muir TW. Autoregulation of a bacterial sigma factor explored by using segmental isotopic labeling and NMR. Proceedings of the National Academy of Sciences of the United States of America. 99: 8536-41. PMID 12084914 DOI: 10.1073/Pnas.132033899  0.351
2002 Flavell RR, Huse M, Goger M, Trester-Zedlitz M, Kuriyan J, Muir TW. Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor. Organic Letters. 4: 165-8. PMID 11796041 DOI: 10.1021/Ol016859I  0.791
2002 Lyon GJ, Wright JS, Christopoulos A, Novick RP, Muir TW. Reversible and specific extracellular antagonism of receptor-histidine kinase signaling. The Journal of Biological Chemistry. 277: 6247-53. PMID 11733525 DOI: 10.1074/Jbc.M109989200  0.701
2001 Camarero JA, Muir TW. Native chemical ligation of polypeptides. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit18.4. PMID 18429140 DOI: 10.1002/0471140864.Ps1804S15  0.427
2001 Hofmann RM, Cotton GJ, Chang EJ, Vidal E, Veach D, Bornmann W, Muir TW. Fluorescent monitoring of kinase activity in real time: development of a robust fluorescence-based assay for Abl tyrosine kinase activity. Bioorganic & Medicinal Chemistry Letters. 11: 3091-4. PMID 11720849 DOI: 10.1016/S0960-894X(01)00650-3  0.341
2001 Stanger HE, Syud FA, Espinosa JF, Giriat I, Muir T, Gellman SH. Length-dependent stability and strand length limits in antiparallel beta -sheet secondary structure. Proceedings of the National Academy of Sciences of the United States of America. 98: 12015-20. PMID 11593011 DOI: 10.1073/Pnas.211536998  0.774
2001 Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massagué J. The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Molecular Cell. 8: 671-82. PMID 11583628 DOI: 10.1016/S1097-2765(01)00332-X  0.518
2001 Giriat I, Muir TW, Perler FB. Protein splicing and its applications. Genetic Engineering. 23: 171-99. PMID 11570103  0.806
2001 Camarero JA, Fushman D, Cowburn D, Muir TW. Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain. Bioorganic & Medicinal Chemistry. 9: 2479-84. PMID 11553489 DOI: 10.1016/S0968-0896(01)00217-6  0.429
2001 Cowburn D, Muir TW. Segmental isotopic labeling using expressed protein ligation. Methods in Enzymology. 339: 41-54. PMID 11462824 DOI: 10.1016/S0076-6879(01)39308-4  0.337
2001 Camarero JA, Fushman D, Sato S, Giriat I, Cowburn D, Raleigh DP, Muir TW. Rescuing a destabilized protein fold through backbone cyclization. Journal of Molecular Biology. 308: 1045-62. PMID 11352590 DOI: 10.1006/Jmbi.2001.4631  0.813
2001 Zvara A, Fajardo JE, Escalante M, Cotton G, Muir T, Kirsch KH, Birge RB. Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II Oncogene. 20: 951-961. PMID 11314030 DOI: 10.1038/Sj.Onc.1204173  0.342
2001 Minakhin L, Camarero JA, Holford M, Parker C, Muir TW, Severinov K. Mapping the molecular interface between the sigma(70) subunit of E. coli RNA polymerase and T4 AsiA. Journal of Molecular Biology. 306: 631-42. PMID 11243776 DOI: 10.1006/Jmbi.2001.4445  0.386
2001 Muir TW. Development and application of expressed protein ligation Synlett. 733-740. DOI: 10.1055/S-2001-14577  0.367
2000 Lyon GJ, Mayville P, Muir TW, Novick RP. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proceedings of the National Academy of Sciences of the United States of America. 97: 13330-5. PMID 11087872 DOI: 10.1073/Pnas.97.24.13330  0.704
2000 Blaschke UK, Silberstein J, Muir TW. Protein engineering by expressed protein ligation. Methods in Enzymology. 328: 478-96. PMID 11075362 DOI: 10.1016/S0076-6879(00)28414-0  0.443
2000 Jarraud S, Lyon GJ, Figueiredo AM, Lina G, Gérard L, Vandenesch F, Etienne J, Muir TW, Novick RP. Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. Journal of Bacteriology. 182: 6517-22. PMID 11053400 DOI: 10.1128/Jb.182.22.6517-6522.2000  0.67
2000 Cotton GJ, Muir TW. Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid-phase expressed protein ligation. Chemistry & Biology. 7: 253-61. PMID 10780925 DOI: 10.1016/S1074-5521(00)00100-9  0.475
2000 Huse M, Holford MN, Kuriyan J, Muir TW. Semisynthesis of hyperphosphorylated type I TGFβ receptor: Addressing the mechanism of kinase activation [20] Journal of the American Chemical Society. 122: 8337-8338. DOI: 10.1021/Ja001763P  0.503
2000 Blaschke UK, Cotton GJ, Muir TW. Synthesis of multi-domain proteins using Expressed Protein Ligation: Strategies for segmental isotopic labeling of internal regions Tetrahedron. 56: 9461-9470. DOI: 10.1016/S0040-4020(00)00830-9  0.434
2000 Camarero JA, Adeva A, Muir TW. 3-Thiopropionic acid as a highly versatile multidetachable thioester resin linker International Journal of Peptide Research and Therapeutics. 7: 17-21. DOI: 10.1007/Bf02443557  0.328
1999 Ayers B, Blaschke UK, Camarero JA, Cotton GJ, Holford M, Muir TW. Introduction of unnatural amino acids into proteins using expressed protein ligation. Biopolymers. 51: 343-54. PMID 10685045 DOI: 10.1002/(Sici)1097-0282(1999)51:5<343::Aid-Bip4>3.0.Co;2-W  0.458
1999 Layfield R, Franklin K, Landon M, Walker G, Wang P, Ramage R, Brown A, Love S, Urquhart K, Muir T, Baker R, Mayer RJ. Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes. Analytical Biochemistry. 274: 40-9. PMID 10527495 DOI: 10.1006/Abio.1999.4234  0.632
1999 Cotton GJ, Muir TW. Peptide ligation and its application to protein engineering. Chemistry & Biology. 6: R247-56. PMID 10467135 DOI: 10.1016/S1074-5521(99)80109-4  0.437
1999 Novick RP, Muir TW. Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria. Current Opinion in Microbiology. 2: 40-5. PMID 10047551 DOI: 10.1016/S1369-5274(99)80007-1  0.518
1999 Mayville P, Ji G, Beavis R, Yang H, Goger M, Novick RP, Muir TW. Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proceedings of the National Academy of Sciences of the United States of America. 96: 1218-23. PMID 9990004 DOI: 10.1073/Pnas.96.4.1218  0.557
1999 Xu R, Ayers B, Cowburn D, Muir TW. Chemical ligation of folded recombinant proteins: segmental isotopic labeling of domains for NMR studies. Proceedings of the National Academy of Sciences of the United States of America. 96: 388-93. PMID 9892643 DOI: 10.1073/Pnas.96.2.388  0.471
1999 Camarero JA, Muir TW. Biosynthesis of a head-to-tail cyclized protein with improved biological activity Journal of the American Chemical Society. 121: 5597-5598. DOI: 10.1021/Ja990929N  0.479
1999 Cotton GJ, Ayers B, Xu R, Muir TW. Insertion of a synthetic peptide into a recombinant protein framework: A protein biosensor [7] Journal of the American Chemical Society. 121: 1100-1101. DOI: 10.1021/Ja983804B  0.44
1999 Ayers B, Blaschke UK, Camarero JA, Cotton GJ, Holford M, Muir TW. Introduction of unnatural amino acids into proteins using expressed protein ligationStandard IUPAC single- and triple-letter codes for amino acids are used throughout the article Biopolymers. 51: 343. DOI: 10.1002/(Sici)1097-0282(1999)51:5<343::Aid-Bip4>3.3.Co;2-N  0.334
1998 Camarero JA, Pavel J, Muir TW. Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization. Angewandte Chemie (International Ed. in English). 37: 347-349. PMID 29711251 DOI: 10.1002/(Sici)1521-3773(19980216)37:3<347::Aid-Anie347>3.0.Co;2-5  0.375
1998 Holford M, Muir TW. Adding 'splice' to protein engineering. Structure (London, England : 1993). 6: 951-6. PMID 9739093 DOI: 10.1016/S0969-2126(98)00097-5  0.432
1998 Severinov K, Muir TW. Expressed protein ligation, a novel method for studying protein-protein interactions in transcription. The Journal of Biological Chemistry. 273: 16205-9. PMID 9632677 DOI: 10.1074/Jbc.273.26.16205  0.454
1998 Muir TW, Sondhi D, Cole PA. Expressed protein ligation: a general method for protein engineering. Proceedings of the National Academy of Sciences of the United States of America. 95: 6705-10. PMID 9618476 DOI: 10.1073/Pnas.95.12.6705  0.466
1998 Camarero JA, Cotton GJ, Adeva A, Muir TW. Chemical ligation of unprotected peptides directly from a solid support. The Journal of Peptide Research : Official Journal of the American Peptide Society. 51: 303-16. PMID 9560006 DOI: 10.1111/J.1399-3011.1998.Tb00428.X  0.321
1997 Muir TW, Dawson PE, Fitzgerald MC, Kent SB. Protein signature analysis: a practical new approach for studying structure-activity relationships in peptides and proteins. Methods in Enzymology. 289: 545-64. PMID 9353737 DOI: 10.1016/S0076-6879(97)89063-5  0.775
1997 Muir TW, Dawson PE, Kent SB. Protein synthesis by chemical ligation of unprotected peptides in aqueous solution. Methods in Enzymology. 289: 266-98. PMID 9353726 DOI: 10.1016/S0076-6879(97)89052-0  0.678
1997 Franklin K, Layfield R, Landon M, Ramage R, Brown A, Love S, Muir T, Urquhart K, Bownes M, Mayer RJ. Capillary electrophoresis assay for ubiquitin carboxyl-terminal hydrolases with chemically synthesized ubiquitin-valine as substrate. Analytical Biochemistry. 247: 305-9. PMID 9177692 DOI: 10.1006/Abio.1997.2099  0.624
1997 Love SG, Muir TW, Ramage R, Shaw KT, Alexeev D, Sawyer L, Kelly SM, Price NC, Arnold JE, Mee MP, Mayer RJ. Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids. The Biochemical Journal. 323: 727-34. PMID 9169606 DOI: 10.1042/Bj3230727  0.638
1997 Stewart PL, Chiu CY, Huang S, Muir T, Zhao Y, Chait B, Mathias P, Nemerow GR. Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization Embo Journal. 16: 1189-1198. PMID 9135136 DOI: 10.1093/Emboj/16.6.1189  0.305
1997 Camarero JA, Muir TW. Chemoselective backbone cyclization of unprotected peptides Chemical Communications. 1369-1370. DOI: 10.1039/A702083J  0.313
1997 Dawson PE, Fitzgerald MC, Muir TW, Kent SBH. Methods for the chemical synthesis and readout of self-encoded arrays of polypeptide analogues Journal of the American Chemical Society. 119: 7917-7927. DOI: 10.1021/Ja963122T  0.662
1996 Muir TW, Dawson PE, Fitzgerald MC, Kent SB. Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis. Chemistry & Biology. 3: 817-25. PMID 8939700 DOI: 10.1016/S1074-5521(96)90067-8  0.783
1996 Zhao Y, Muir TW, Kent SB, Tischer E, Scardina JM, Chait BT. Mapping protein-protein interactions by affinity-directed mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 93: 4020-4. PMID 8633009 DOI: 10.1073/Pnas.93.9.4020  0.568
1995 Muir TW. A chemical approach to the construction of multimeric protein assemblies. Structure (London, England : 1993). 3: 649-52. PMID 8591042 DOI: 10.1016/S0969-2126(01)00200-3  0.465
1995 Muir TW, Williams MJ, Kent SB. Detection of synthetic protein isomers and conformers by electrospray mass spectrometry. Analytical Biochemistry. 224: 100-9. PMID 7710055 DOI: 10.1006/Abio.1995.1013  0.538
1994 Alexeev D, Bury SM, Turner MA, Ogunjobi OM, Muir TW, Ramage R, Sawyer L. Synthetic, structural and biological studies of the ubiquitin system: chemically synthesized and native ubiquitin fold into identical three-dimensional structures. The Biochemical Journal. 299: 159-63. PMID 8166634 DOI: 10.1042/Bj2990159  0.61
1994 Ramage R, Green J, Muir TW, Ogunjobi OM, Love S, Shaw K. Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin. The Biochemical Journal. 299: 151-8. PMID 8166633 DOI: 10.1042/Bj2990151  0.593
1994 Dawson PE, Muir TW, Clark-Lewis I, Kent SB. Synthesis of proteins by native chemical ligation. Science (New York, N.Y.). 266: 776-9. PMID 7973629  0.692
1994 Muir TW, Williams MJ, Ginsberg MH, Kent SB. Design and chemical synthesis of a neoprotein structural model for the cytoplasmic domain of a multisubunit cell-surface receptor: integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Biochemistry. 33: 7701-8. PMID 7516703 DOI: 10.1021/Bi00190A025  0.554
1994 Williams MJ, Muir TW, Ginsberg MH, Kent SBH. Total chemical synthesis of a folded β-sandwich protein domain: An analog of the tenth fibronectin type 3 module Journal of the American Chemical Society. 116: 10797-10798. DOI: 10.1021/Ja00102A060  0.357
1993 Muir TW, Kent SB. The chemical synthesis of proteins. Current Opinion in Biotechnology. 4: 420-7. PMID 7763972 DOI: 10.1016/0958-1669(93)90007-J  0.621
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