Thomas W. Muir, Ph.D. - Publications

Affiliations: 
1996-2011 Chemistry Rockefeller University, New York, NY, United States 
 2011- Chemistry Princeton University, Princeton, NJ 
Area:
physiochemical basis of protein function
Website:
https://chemistry.princeton.edu/faculty/muir

169 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zhou L, Holt MT, Ohashi N, Zhao A, Müller MM, Wang B, Muir TW. Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nature Communications. 7: 10589. PMID 26830124 DOI: 10.1038/ncomms10589  1
2016 Müller MM, Fierz B, Bittova L, Liszczak G, Muir TW. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nature Chemical Biology. PMID 26807716 DOI: 10.1038/nchembio.2008  1
2015 Beh LY, Müller MM, Muir TW, Kaplan N, Landweber LF. DNA-guided establishment of nucleosome patterns within coding regions of a eukaryotic genome. Genome Research. 25: 1727-38. PMID 26330564 DOI: 10.1101/gr.188516.114  1
2015 Wang B, Zhao A, Novick RP, Muir TW. Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence. Proceedings of the National Academy of Sciences of the United States of America. 112: 10679-84. PMID 26261307 DOI: 10.1073/pnas.1506030112  1
2015 Holt MT, David Y, Pollock S, Tang Z, Jeon J, Kim J, Roeder RG, Muir TW. Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. Proceedings of the National Academy of Sciences of the United States of America. PMID 26240340 DOI: 10.1073/pnas.1504483112  1
2015 David Y, Vila-Perelló M, Verma S, Muir TW. Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins. Nature Chemistry. 7: 394-402. PMID 25901817 DOI: 10.1038/nchem.2224  1
2015 Brown ZZ, Müller MM, Kong HE, Lewis PW, Muir TW. Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin. Angewandte Chemie (International Ed. in English). 54: 6457-61. PMID 25873363 DOI: 10.1002/anie.201500085  1
2015 Johnson JG, Wang B, Debelouchina GT, Novick RP, Muir TW. Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus. Chembiochem : a European Journal of Chemical Biology. 16: 1093-100. PMID 25801678 DOI: 10.1002/cbic.201500006  1
2015 Holt M, Muir T. Application of the protein semisynthesis strategy to the generation of modified chromatin. Annual Review of Biochemistry. 84: 265-90. PMID 25784050 DOI: 10.1146/annurev-biochem-060614-034429  1
2015 Kee JM, Oslund RC, Couvillon AD, Muir TW. A second-generation phosphohistidine analog for production of phosphohistidine antibodies. Organic Letters. 17: 187-9. PMID 25531910 DOI: 10.1021/ol503320p  1
2015 Müller MM, Muir TW. Histones: at the crossroads of peptide and protein chemistry. Chemical Reviews. 115: 2296-349. PMID 25330018 DOI: 10.1021/cr5003529  1
2015 Wang B, Zhao A, Novick RP, Muir TW. Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence Proceedings of the National Academy of Sciences of the United States of America. 112: 10679-10684. DOI: 10.1073/pnas.1506030112  1
2014 Brown ZZ, Müller MM, Jain SU, Allis CD, Lewis PW, Muir TW. Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2. Journal of the American Chemical Society. 136: 13498-501. PMID 25180930 DOI: 10.1021/ja5060934  1
2014 Oslund RC, Kee JM, Couvillon AD, Bhatia VN, Perlman DH, Muir TW. A phosphohistidine proteomics strategy based on elucidation of a unique gas-phase phosphopeptide fragmentation mechanism. Journal of the American Chemical Society. 136: 12899-911. PMID 25156620 DOI: 10.1021/ja507614f  1
2014 Nguyen UT, Bittova L, Müller MM, Fierz B, David Y, Houck-Loomis B, Feng V, Dann GP, Muir TW. Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries. Nature Methods. 11: 834-40. PMID 24997861 DOI: 10.1038/nmeth.3022  1
2014 Liu Z, Frutos S, Bick MJ, Vila-Perelló M, Debelouchina GT, Darst SA, Muir TW. Structure of the branched intermediate in protein splicing. Proceedings of the National Academy of Sciences of the United States of America. 111: 8422-7. PMID 24778214 DOI: 10.1073/pnas.1402942111  1
2014 Eryilmaz E, Shah NH, Muir TW, Cowburn D. Structural and dynamical features of inteins and implications on protein splicing. The Journal of Biological Chemistry. 289: 14506-11. PMID 24695731 DOI: 10.1074/jbc.R113.540302  1
2014 Wang B, Zhao A, Novick RP, Muir TW. Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions. Molecular Cell. 53: 929-40. PMID 24656130 DOI: 10.1016/j.molcel.2014.02.029  1
2014 Shah NH, Muir TW. Inteins: Nature's Gift to Protein Chemists. Chemical Science (Royal Society of Chemistry : 2010). 5: 446-461. PMID 24634716 DOI: 10.1039/C3SC52951G  1
2014 Eryilmaz E, Shah NH, Muir TW, Cowburn D. Structural and dynamical features of inteins and implications on protein splicing (Journal of Biological Chemistry (2014) 289 (14506-14511)) Journal of Biological Chemistry. 289: 19278. DOI: 10.1074/jbc.A113.540302  1
2013 Shah NH, Eryilmaz E, Cowburn D, Muir TW. Naturally split inteins assemble through a "capture and collapse" mechanism. Journal of the American Chemical Society. 135: 18673-81. PMID 24236406 DOI: 10.1021/ja4104364  1
2013 Kim DH, Tang Z, Shimada M, Fierz B, Houck-Loomis B, Bar-Dagen M, Lee S, Lee SK, Muir TW, Roeder RG, Lee JW. Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes. Molecular and Cellular Biology. 33: 4936-46. PMID 24126056 DOI: 10.1128/MCB.00601-13  1
2013 Casadio F, Lu X, Pollock SB, LeRoy G, Garcia BA, Muir TW, Roeder RG, Allis CD. H3R42me2a is a histone modification with positive transcriptional effects. Proceedings of the National Academy of Sciences of the United States of America. 110: 14894-9. PMID 23980157 DOI: 10.1073/pnas.1312925110  1
2013 Tang Z, Chen WY, Shimada M, Nguyen UT, Kim J, Sun XJ, Sengoku T, McGinty RK, Fernandez JP, Muir TW, Roeder RG. SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell. 154: 297-310. PMID 23870121 DOI: 10.1016/j.cell.2013.06.027  1
2013 Kee JM, Oslund RC, Perlman DH, Muir TW. A pan-specific antibody for direct detection of protein histidine phosphorylation. Nature Chemical Biology. 9: 416-21. PMID 23708076 DOI: 10.1038/nchembio.1259  1
2013 Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (New York, N.Y.). 340: 857-61. PMID 23539183 DOI: 10.1126/science.1232245  1
2013 Shah NH, Eryilmaz E, Cowburn D, Muir TW. Extein residues play an intimate role in the rate-limiting step of protein trans-splicing. Journal of the American Chemical Society. 135: 5839-47. PMID 23506399 DOI: 10.1021/ja401015p  1
2013 Kim J, Kim JA, McGinty RK, Nguyen UT, Muir TW, Allis CD, Roeder RG. The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Molecular Cell. 49: 1121-33. PMID 23453808 DOI: 10.1016/j.molcel.2013.01.034  1
2013 Wu L, Lee SY, Zhou B, Nguyen UT, Muir TW, Tan S, Dou Y. ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes. Molecular Cell. 49: 1108-20. PMID 23453805 DOI: 10.1016/j.molcel.2013.01.033  1
2013 Barbuto S, Idoyaga J, Vila-Perelló M, Longhi MP, Breton G, Steinman RM, Muir TW. Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells. Nature Chemical Biology. 9: 250-6. PMID 23416331 DOI: 10.1038/nchembio.1186  1
2013 Vila-Perelló M, Liu Z, Shah NH, Willis JA, Idoyaga J, Muir TW. Streamlined expressed protein ligation using split inteins. Journal of the American Chemical Society. 135: 286-92. PMID 23265282 DOI: 10.1021/ja309126m  1
2012 Fierz B, Kilic S, Hieb AR, Luger K, Muir TW. Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis. Journal of the American Chemical Society. 134: 19548-51. PMID 23163596 DOI: 10.1021/ja308908p  1
2012 Shah NH, Dann GP, Vila-Perelló M, Liu Z, Muir TW. Ultrafast protein splicing is common among cyanobacterial split inteins: implications for protein engineering. Journal of the American Chemical Society. 134: 11338-41. PMID 22734434 DOI: 10.1021/ja303226x  1
2012 Whitcomb SJ, Fierz B, McGinty RK, Holt M, Ito T, Muir TW, Allis CD. Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2. The Journal of Biological Chemistry. 287: 23718-25. PMID 22619169 DOI: 10.1074/jbc.M112.361824  1
2012 Brown ZZ, Muir TW. From EPOthilone to EPO: Aa challenge for natural product synthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 7134-5. PMID 22529360 DOI: 10.1073/pnas.1205667109  1
2012 Fierz B, Muir TW. Chromatin as an expansive canvas for chemical biology. Nature Chemical Biology. 8: 417-27. PMID 22510649 DOI: 10.1038/nchembio.938  1
2012 Kee JM, Muir TW. Chasing phosphohistidine, an elusive sibling in the phosphoamino acid family. Acs Chemical Biology. 7: 44-51. PMID 22148577 DOI: 10.1021/cb200445w  1
2012 Geisinger E, George EA, Chen J, Muir TW, Novick RP. Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor (Journal of Biological Chemistry (2012) 283, (8930-8938)) Journal of Biological Chemistry. 287: 18588. DOI: 10.1074/jbc.A112.710227  1
2011 Shah NH, Muir TW. Split Inteins: Nature's Protein Ligases. Israel Journal of Chemistry. 51: 854-861. PMID 23620603 DOI: 10.1002/ijch.201100094  1
2011 Janz JM, Ren Y, Looby R, Kazmi MA, Sachdev P, Grunbeck A, Haggis L, Chinnapen D, Lin AY, Seibert C, McMurry T, Carlson KE, Muir TW, Hunt S, Sakmar TP. Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. Journal of the American Chemical Society. 133: 15878-81. PMID 21905700 DOI: 10.1021/ja206661w  1
2011 Nguyen DP, Elliott T, Holt M, Muir TW, Chin JW. Genetically encoded 1,2-aminothiols facilitate rapid and site-specific protein labeling via a bio-orthogonal cyanobenzothiazole condensation. Journal of the American Chemical Society. 133: 11418-21. PMID 21736333 DOI: 10.1021/ja203111c  1
2011 Shah NH, Vila-Perelló M, Muir TW. Kinetic control of one-pot trans-splicing reactions by using a wild-type and designed split intein. Angewandte Chemie (International Ed. in English). 50: 6511-5. PMID 21656885 DOI: 10.1002/anie.201102909  1
2011 Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD. Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell. 145: 692-706. PMID 21596426 DOI: 10.1016/j.cell.2011.03.053  1
2011 Cho JH, Muralidharan V, Vila-Perello M, Raleigh DP, Muir TW, Palmer AG. Tuning protein autoinhibition by domain destabilization. Nature Structural & Molecular Biology. 18: 550-5. PMID 21532593 DOI: 10.1038/nsmb.2039  1
2011 Singla N, Erdjument-Bromage H, Himanen JP, Muir TW, Nikolov DB. A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation. Chemistry & Biology. 18: 361-71. PMID 21439481 DOI: 10.1016/j.chembiol.2011.01.011  1
2011 Allis CD, Muir TW. Spreading chromatin into chemical biology. Chembiochem : a European Journal of Chemical Biology. 12: 264-79. PMID 21243714 DOI: 10.1002/cbic.201000761  1
2011 Fierz B, Chatterjee C, McGinty RK, Bar-Dagan M, Raleigh DP, Muir TW. Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nature Chemical Biology. 7: 113-9. PMID 21196936 DOI: 10.1038/nchembio.501  1
2010 Moyle PM, Muir TW. Method for the synthesis of mono-ADP-ribose conjugated peptides. Journal of the American Chemical Society. 132: 15878-80. PMID 20968292 DOI: 10.1021/ja1064312  1
2010 Vila-Perelló M, Muir TW. Biological applications of protein splicing. Cell. 143: 191-200. PMID 20946979 DOI: 10.1016/j.cell.2010.09.031  1
2010 Kee JM, Villani B, Carpenter LR, Muir TW. Development of stable phosphohistidine analogues. Journal of the American Chemical Society. 132: 14327-9. PMID 20879710 DOI: 10.1021/ja104393t  1
2010 Frutos S, Goger M, Giovani B, Cowburn D, Muir TW. Branched intermediate formation stimulates peptide bond cleavage in protein splicing. Nature Chemical Biology. 6: 527-33. PMID 20495572 DOI: 10.1038/nchembio.371  1
2010 Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S, Wilm M, Muir TW, Müller J. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature. 465: 243-7. PMID 20436459 DOI: 10.1038/nature08966  1
2010 Chatterjee C, McGinty RK, Fierz B, Muir TW. Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nature Chemical Biology. 6: 267-9. PMID 20208522 DOI: 10.1038/nchembio.315  1
2010 Chatterjee C, Muir TW. Chemical approaches for studying histone modifications. The Journal of Biological Chemistry. 285: 11045-50. PMID 20147749 DOI: 10.1074/jbc.R109.080291  1
2009 Averette KM, Pratt MR, Yang Y, Bassilian S, Whitelegge JP, Loo JA, Muir TW, Bradley KA. Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent. Plos One. 4: e7913. PMID 19924255 DOI: 10.1371/journal.pone.0007913  1
2009 McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW. Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. Acs Chemical Biology. 4: 958-68. PMID 19799466 DOI: 10.1021/cb9002255  1
2009 Pratt MR, Sekedat MD, Chiang KP, Muir TW. Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe. Chemistry & Biology. 16: 1001-12. PMID 19778728 DOI: 10.1016/j.chembiol.2009.07.011  1
2009 George Cisar EA, Geisinger E, Muir TW, Novick RP. Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC. Molecular Microbiology. 74: 44-57. PMID 19708918 DOI: 10.1111/j.1365-2958.2009.06849.x  1
2009 Ceccarini G, Flavell RR, Butelman ER, Synan M, Willnow TE, Bar-Dagan M, Goldsmith SJ, Kreek MJ, Kothari P, Vallabhajosula S, Muir TW, Friedman JM. PET imaging of leptin biodistribution and metabolism in rodents and primates. Cell Metabolism. 10: 148-59. PMID 19656493 DOI: 10.1016/j.cmet.2009.07.001  1
2009 McGinty RK, Chatterjee C, Muir TW. Semisynthesis of ubiquitylated proteins. Methods in Enzymology. 462: 225-43. PMID 19632477 DOI: 10.1016/S0076-6879(09)62011-5  1
2009 Muir TW. Non-natural amino acids. Preface. Methods in Enzymology. 462: xiii-xv. PMID 19632466 DOI: 10.1016/S0076-6879(09)62016-4  1
2009 Chiang KP, Jensen MS, McGinty RK, Muir TW. A semisynthetic strategy to generate phosphorylated and acetylated histone H2B. Chembiochem : a European Journal of Chemical Biology. 10: 2182-7. PMID 19623598 DOI: 10.1002/cbic.200900238  1
2009 Lockless SW, Muir TW. Traceless protein splicing utilizing evolved split inteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 10999-1004. PMID 19541616 DOI: 10.1073/pnas.0902964106  1
2009 Kim J, Guermah M, McGinty RK, Lee JS, Tang Z, Milne TA, Shilatifard A, Muir TW, Roeder RG. RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell. 137: 459-71. PMID 19410543 DOI: 10.1016/j.cell.2009.02.027  1
2009 Muir TW. Chemical biology in a time of transition. Acs Chemical Biology. 4: 241-3. PMID 19371132 DOI: 10.1021/cb900077q  1
2009 Geisinger E, Muir TW, Novick RP. agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides. Proceedings of the National Academy of Sciences of the United States of America. 106: 1216-21. PMID 19147840 DOI: 10.1073/pnas.0807760106  1
2009 Flavell RR, Muir TW. Expressed protein ligation (EPL) in the study of signal transduction, ion conduction, and chromatin biology. Accounts of Chemical Research. 42: 107-16. PMID 18939858 DOI: 10.1021/ar800129c  1
2008 Chiang KP, Muir TW. Systems- and molecular-level elucidation of signaling processes through chemistry. Science Signaling. 1: pe45. PMID 18941136 DOI: 10.1126/scisignal.142pe45  1
2008 Schwartz EC, Shekhtman A, Dutta K, Pratt MR, Cowburn D, Darst S, Muir TW. A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding. Chemistry & Biology. 15: 1091-103. PMID 18940669 DOI: 10.1016/j.chembiol.2008.09.008  1
2008 Muir TW. Studying protein structure and function using semisynthesis. Biopolymers. 90: 743-50. PMID 18924136 DOI: 10.1002/bip.21102  1
2008 Vila-Perelló M, Hori Y, Ribó M, Muir TW. Activation of protein splicing by protease- or light-triggered O to N acyl migration. Angewandte Chemie (International Ed. in English). 47: 7764-7. PMID 18767096 DOI: 10.1002/anie.200802502  1
2008 Singla N, Himanen JP, Muir TW, Nikolov DB. Toward the semisynthesis of multidomain transmembrane receptors: modification of Eph tyrosine kinases. Protein Science : a Publication of the Protein Society. 17: 1740-7. PMID 18628240 DOI: 10.1110/ps.035659.108  1
2008 Flavell RR, Kothari P, Bar-Dagan M, Synan M, Vallabhajosula S, Friedman JM, Muir TW, Ceccarini G. Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure. Journal of the American Chemical Society. 130: 9106-12. PMID 18570424 DOI: 10.1021/ja801666z  1
2008 McGinty RK, Kim J, Chatterjee C, Roeder RG, Muir TW. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature. 453: 812-6. PMID 18449190 DOI: 10.1038/nature06906  1
2008 George EA, Novick RP, Muir TW. Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis. Journal of the American Chemical Society. 130: 4914-24. PMID 18335939 DOI: 10.1021/ja711126e  1
2008 Tyszkiewicz AB, Muir TW. Activation of protein splicing with light in yeast. Nature Methods. 5: 303-5. PMID 18272963 DOI: 10.1038/nmeth.1189  1
2008 Geisinger E, George EA, Chen J, Muir TW, Novick RP. Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor. The Journal of Biological Chemistry. 283: 8930-8. PMID 18222919 DOI: 10.1074/jbc.M710227200  1
2008 Ottesen JJ, Bar-Dagan M, Giovani B, Muir TW. An amalgamation of solid phase peptide synthesis and ribosomal peptide synthesis. Biopolymers. 90: 406-14. PMID 17636509 DOI: 10.1002/bip.20810  1
2008 Pratt MR, Muir TW. Synthesis of Large Biological Molecules: Expressed Protein Ligation Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 2: 537-566. DOI: 10.1002/9783527619375.ch10a  1
2007 Hahn ME, Pellois JP, Vila-Perelló M, Muir TW. Tunable photoactivation of a post-translationally modified signaling protein and its unmodified counterpart in live cells. Chembiochem : a European Journal of Chemical Biology. 8: 2100-5. PMID 17907120 DOI: 10.1002/cbic.200700404  1
2007 Vila-Perelló M, Pratt MR, Tulin F, Muir TW. Covalent capture of phospho-dependent protein oligomerization by site-specific incorporation of a diazirine photo-cross-linker. Journal of the American Chemical Society. 129: 8068-9. PMID 17567014 DOI: 10.1021/ja072013j  1
2007 Pratt MR, Schwartz EC, Muir TW. Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt. Proceedings of the National Academy of Sciences of the United States of America. 104: 11209-14. PMID 17563385 DOI: 10.1073/pnas.0700816104  1
2007 George EA, Muir TW. Molecular mechanisms of agr quorum sensing in virulent staphylococci. Chembiochem : a European Journal of Chemical Biology. 8: 847-55. PMID 17457814 DOI: 10.1002/cbic.200700023  1
2007 Chatterjee C, McGinty RK, Pellois JP, Muir TW. Auxiliary-mediated site-specific peptide ubiquitylation. Angewandte Chemie (International Ed. in English). 46: 2814-8. PMID 17366504 DOI: 10.1002/anie.200605155  1
2007 Schwartz EC, Saez L, Young MW, Muir TW. Post-translational enzyme activation in an animal via optimized conditional protein splicing. Nature Chemical Biology. 3: 50-4. PMID 17128262 DOI: 10.1038/nchembio832  1
2006 Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R. Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science (New York, N.Y.). 314: 1004-7. PMID 17095703 DOI: 10.1126/science.1133415  1
2006 Valiyaveetil FI, Sekedat M, MacKinnon R, Muir TW. Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel. Journal of the American Chemical Society. 128: 11591-9. PMID 16939283 DOI: 10.1021/ja0631955  1
2006 Pellois JP, Muir TW. Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't. Current Opinion in Chemical Biology. 10: 487-91. PMID 16935551 DOI: 10.1016/j.cbpa.2006.08.016  1
2006 Muir TW. Chemical biology: cutting out the middle man. Nature. 442: 517-8. PMID 16885971 DOI: 10.1038/442517a  1
2006 Muralidharan V, Dutta K, Cho J, Vila-Perello M, Raleigh DP, Cowburn D, Muir TW. Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II. Biochemistry. 45: 8874-84. PMID 16846230 DOI: 10.1021/bi060590z  1
2006 Muralidharan V, Muir TW. Protein ligation: an enabling technology for the biophysical analysis of proteins. Nature Methods. 3: 429-38. PMID 16721376 DOI: 10.1038/nmeth886  1
2005 Muir TW. 2005 Irving Sigal Young Investigator Award. Protein Science : a Publication of the Protein Society. 14: 3140-4. PMID 16322585 DOI: 10.1110/ps.051848105  1
2005 Pellois JP, Muir TW. A ligation and photorelease strategy for the temporal and spatial control of protein function in living cells. Angewandte Chemie (International Ed. in English). 44: 5713-7. PMID 16059958 DOI: 10.1002/anie.200501244  1
2005 Shi J, Muir TW. Development of a tandem protein trans-splicing system based on native and engineered split inteins. Journal of the American Chemical Society. 127: 6198-206. PMID 15853324 DOI: 10.1021/ja042287w  1
2005 Hahn ME, Muir TW. Manipulating proteins with chemistry: a cross-section of chemical biology. Trends in Biochemical Sciences. 30: 26-34. PMID 15653323 DOI: 10.1016/j.tibs.2004.10.010  1
2005 Strobel SA, Muir TW. Biopolymers: Exploring biological function through chemical manipulation of biopolymers Current Opinion in Chemical Biology. 9: 545-547. DOI: 10.1016/j.cbpa.2005.10.017  1
2004 Valiyaveetil FI, Sekedat M, Mackinnon R, Muir TW. Glycine as a D-amino acid surrogate in the K(+)-selectivity filter. Proceedings of the National Academy of Sciences of the United States of America. 101: 17045-9. PMID 15563591 DOI: 10.1073/pnas.0407820101  1
2004 Wright JS, Lyon GJ, George EA, Muir TW, Novick RP. Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing. Proceedings of the National Academy of Sciences of the United States of America. 101: 16168-73. PMID 15528279 DOI: 10.1073/pnas.0404039101  1
2004 Hahn ME, Muir TW. Photocontrol of Smad2, a multiphosphorylated cell-signaling protein, through caging of activating phosphoserines. Angewandte Chemie (International Ed. in English). 43: 5800-3. PMID 15523718 DOI: 10.1002/anie.200461141  1
2004 Muralidharan V, Cho J, Trester-Zedlitz M, Kowalik L, Chait BT, Raleigh DP, Muir TW. Domain-specific incorporation of noninvasive optical probes into recombinant proteins. Journal of the American Chemical Society. 126: 14004-12. PMID 15506763 DOI: 10.1021/ja0466199  1
2004 Mootz HD, Blum ES, Muir TW. Activation of an autoregulated protein kinase by conditional protein splicing. Angewandte Chemie (International Ed. in English). 43: 5189-92. PMID 15455415 DOI: 10.1002/anie.200460941  1
2004 Cowburn D, Shekhtman A, Xu R, Ottesen JJ, Muir TW. Segmental isotopic labeling for structural biological applications of NMR. Methods in Molecular Biology (Clifton, N.J.). 278: 47-56. PMID 15317990 DOI: 10.1385/1-59259-809-9:047  1
2004 Pellois JP, Hahn ME, Muir TW. Simultaneous triggering of protein activity and fluorescence. Journal of the American Chemical Society. 126: 7170-1. PMID 15186142 DOI: 10.1021/ja0499142  1
2004 Ottesen JJ, Huse M, Sekedat MD, Muir TW. Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase. Biochemistry. 43: 5698-706. PMID 15134444 DOI: 10.1021/bi0498407  1
2004 Valiyaveetil FI, Sekedat M, Muir TW, MacKinnon R. Semisynthesis of a functional K+ channel. Angewandte Chemie (International Ed. in English). 43: 2504-7. PMID 15127436 DOI: 10.1002/anie.200453849  1
2004 Romanelli A, Shekhtman A, Cowburn D, Muir TW. Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein-intein junction. Proceedings of the National Academy of Sciences of the United States of America. 101: 6397-402. PMID 15087498 DOI: 10.1073/pnas.0306616101  1
2003 Lyon GJ, Muir TW. Chemical signaling among bacteria and its inhibition. Chemistry & Biology. 10: 1007-21. PMID 14652068 DOI: 10.1016/j.chembiol.2003.11.003  1
2003 Muir TW. Turning virulence on and off in staphylococci. Journal of Peptide Science : An Official Publication of the European Peptide Society. 9: 612-9. PMID 14620127 DOI: 10.1002/psc.486  1
2003 Schwartz EC, Muir TW, Tyszkiewicz AB. "The splice is right": how protein splicing is opening new doors in protein science. Chemical Communications (Cambridge, England). 2087-90. PMID 13678154  1
2003 Mootz HD, Blum ES, Tyszkiewicz AB, Muir TW. Conditional protein splicing: a new tool to control protein structure and function in vitro and in vivo. Journal of the American Chemical Society. 125: 10561-9. PMID 12940738 DOI: 10.1021/ja0362813  1
2003 Giriat I, Muir TW. Protein semi-synthesis in living cells. Journal of the American Chemical Society. 125: 7180-1. PMID 12797783 DOI: 10.1021/ja034736i  1
2003 Muir TW. Semisynthesis of proteins by expressed protein ligation. Annual Review of Biochemistry. 72: 249-89. PMID 12626339 DOI: 10.1146/annurev.biochem.72.121801.161900  1
2003 Trester-Zedlitz M, Kamada K, Burley SK, Fenyö D, Chait BT, Muir TW. A modular cross-linking approach for exploring protein interactions. Journal of the American Chemical Society. 125: 2416-25. PMID 12603129 DOI: 10.1021/ja026917a  1
2003 Miller JS, Dudkin VY, Lyon GJ, Muir TW, Danishefsky SJ. Toward fully synthetic N-linked glycoproteins. Angewandte Chemie (International Ed. in English). 42: 431-4. PMID 12569509 DOI: 10.1002/anie.200390131  1
2002 Muir TW, McGinty R, Pratt M, Chatterjee C, Schwartz E. Making and Breaking Ubiquitin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4113. PMID 29430986 DOI: 10.1096/fasebj.22.1_supplement.411.3  1
2002 Hofmann RM, Muir TW. Recent advances in the application of expressed protein ligation to protein engineering. Current Opinion in Biotechnology. 13: 297-303. PMID 12323349 DOI: 10.1016/S0958-1669(02)00326-9  1
2002 Valiyaveetil FI, MacKinnon R, Muir TW. Semisynthesis and folding of the potassium channel KcsA. Journal of the American Chemical Society. 124: 9113-20. PMID 12149015 DOI: 10.1021/ja0266722  1
2002 Mootz HD, Muir TW. Protein splicing triggered by a small molecule. Journal of the American Chemical Society. 124: 9044-5. PMID 12148996 DOI: 10.1021/ja026769o  1
2002 Lyon GJ, Wright JS, Muir TW, Novick RP. Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry. 41: 10095-104. PMID 12146974  1
2002 Camarero JA, Shekhtman A, Campbell EA, Chlenov M, Gruber TM, Bryant DA, Darst SA, Cowburn D, Muir TW. Autoregulation of a bacterial sigma factor explored by using segmental isotopic labeling and NMR. Proceedings of the National Academy of Sciences of the United States of America. 99: 8536-41. PMID 12084914 DOI: 10.1073/pnas.132033899  1
2002 Flavell RR, Huse M, Goger M, Trester-Zedlitz M, Kuriyan J, Muir TW. Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor. Organic Letters. 4: 165-8. PMID 11796041 DOI: 10.1021/ol016859i  1
2002 Lyon GJ, Wright JS, Christopoulos A, Novick RP, Muir TW. Reversible and specific extracellular antagonism of receptor-histidine kinase signaling. The Journal of Biological Chemistry. 277: 6247-53. PMID 11733525 DOI: 10.1074/jbc.M109989200  1
2001 Camarero JA, Muir TW. Native chemical ligation of polypeptides. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit18.4. PMID 18429140 DOI: 10.1002/0471140864.ps1804s15  1
2001 Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massagué J, Shi Y. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Molecular Cell. 8: 1277-89. PMID 11779503 DOI: 10.1016/S1097-2765(01)00421-X  1
2001 Hofmann RM, Cotton GJ, Chang EJ, Vidal E, Veach D, Bornmann W, Muir TW. Fluorescent monitoring of kinase activity in real time: development of a robust fluorescence-based assay for Abl tyrosine kinase activity. Bioorganic & Medicinal Chemistry Letters. 11: 3091-4. PMID 11720849 DOI: 10.1016/S0960-894X(01)00650-3  1
2001 Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massagué J. The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Molecular Cell. 8: 671-82. PMID 11583628 DOI: 10.1016/S1097-2765(01)00332-X  1
2001 Giriat I, Muir TW, Perler FB. Protein splicing and its applications. Genetic Engineering. 23: 171-99. PMID 11570103  1
2001 Camarero JA, Fushman D, Cowburn D, Muir TW. Peptide chemical ligation inside living cells: in vivo generation of a circular protein domain. Bioorganic & Medicinal Chemistry. 9: 2479-84. PMID 11553489 DOI: 10.1016/S0968-0896(01)00217-6  1
2001 Cowburn D, Muir TW. Segmental isotopic labeling using expressed protein ligation. Methods in Enzymology. 339: 41-54. PMID 11462824 DOI: 10.1016/S0076-6879(01)39308-4  1
2001 Camarero JA, Fushman D, Sato S, Giriat I, Cowburn D, Raleigh DP, Muir TW. Rescuing a destabilized protein fold through backbone cyclization. Journal of Molecular Biology. 308: 1045-62. PMID 11352590 DOI: 10.1006/jmbi.2001.4631  1
2001 Minakhin L, Camarero JA, Holford M, Parker C, Muir TW, Severinov K. Mapping the molecular interface between the sigma(70) subunit of E. coli RNA polymerase and T4 AsiA. Journal of Molecular Biology. 306: 631-42. PMID 11243776 DOI: 10.1006/jmbi.2001.4445  1
2001 Muir TW. Development and application of expressed protein ligation Synlett. 733-740.  1
2000 Lyon GJ, Mayville P, Muir TW, Novick RP. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proceedings of the National Academy of Sciences of the United States of America. 97: 13330-5. PMID 11087872 DOI: 10.1073/pnas.97.24.13330  1
2000 Blaschke UK, Silberstein J, Muir TW. Protein engineering by expressed protein ligation. Methods in Enzymology. 328: 478-96. PMID 11075362  1
2000 Jarraud S, Lyon GJ, Figueiredo AM, Lina G, Gérard L, Vandenesch F, Etienne J, Muir TW, Novick RP. Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. Journal of Bacteriology. 182: 6517-22. PMID 11053400 DOI: 10.1128/JB.06355-11  1
2000 Cotton GJ, Muir TW. Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid-phase expressed protein ligation. Chemistry & Biology. 7: 253-61. PMID 10780925 DOI: 10.1016/S1074-5521(00)00100-9  1
2000 Camarero JA, Adeva A, Muir TW. 3-Thiopropionic acid as a highly versatile multidetachable thioester resin linker International Journal of Peptide Research and Therapeutics. 7: 17-21. DOI: 10.1023/A:1008922017011  1
2000 Huse M, Holford MN, Kuriyan J, Muir TW. Semisynthesis of hyperphosphorylated type I TGFβ receptor: Addressing the mechanism of kinase activation [20] Journal of the American Chemical Society. 122: 8337-8338. DOI: 10.1021/ja001763p  1
2000 Blaschke UK, Cotton GJ, Muir TW. Synthesis of multi-domain proteins using Expressed Protein Ligation: Strategies for segmental isotopic labeling of internal regions Tetrahedron. 56: 9461-9470.  1
1999 Ayers B, Blaschke UK, Camarero JA, Cotton GJ, Holford M, Muir TW. Introduction of unnatural amino acids into proteins using expressed protein ligation. Biopolymers. 51: 343-54. PMID 10685045 DOI: 10.1002/(SICI)1097-0282(1999)51:5<343::AID-BIP4>3.0.CO;2-W  1
1999 Cotton GJ, Muir TW. Peptide ligation and its application to protein engineering. Chemistry & Biology. 6: R247-56. PMID 10467135 DOI: 10.1016/S1074-5521(99)80109-4  1
1999 Novick RP, Muir TW. Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria. Current Opinion in Microbiology. 2: 40-5. PMID 10047551 DOI: 10.1016/S1369-5274(99)80007-1  1
1999 Mayville P, Ji G, Beavis R, Yang H, Goger M, Novick RP, Muir TW. Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proceedings of the National Academy of Sciences of the United States of America. 96: 1218-23. PMID 9990004 DOI: 10.1073/pnas.96.4.1218  1
1999 Xu R, Ayers B, Cowburn D, Muir TW. Chemical ligation of folded recombinant proteins: segmental isotopic labeling of domains for NMR studies. Proceedings of the National Academy of Sciences of the United States of America. 96: 388-93. PMID 9892643 DOI: 10.1073/pnas.96.2.388  1
1999 Camarero JA, Muir TW. Biosynthesis of a head-to-tail cyclized protein with improved biological activity Journal of the American Chemical Society. 121: 5597-5598. DOI: 10.1021/ja990929n  1
1999 Cotton GJ, Ayers B, Xu R, Muir TW. Insertion of a synthetic peptide into a recombinant protein framework: A protein biosensor [7] Journal of the American Chemical Society. 121: 1100-1101. DOI: 10.1021/ja983804b  1
1998 Holford M, Muir TW. Adding 'splice' to protein engineering. Structure (London, England : 1993). 6: 951-6. PMID 9739093  1
1998 Severinov K, Muir TW. Expressed protein ligation, a novel method for studying protein-protein interactions in transcription. The Journal of Biological Chemistry. 273: 16205-9. PMID 9632677 DOI: 10.1074/jbc.273.26.16205  1
1998 Muir TW, Sondhi D, Cole PA. Expressed protein ligation: a general method for protein engineering. Proceedings of the National Academy of Sciences of the United States of America. 95: 6705-10. PMID 9618476 DOI: 10.1073/pnas.95.12.6705  1
1998 Camarero JA, Ayers B, Muir TW. Studying receptor-ligand interactions using encoded amino acid scanning. Biochemistry. 37: 7487-95. PMID 9585562 DOI: 10.1021/bi973122l  1
1998 Camarero JA, Cotton GJ, Adeva A, Muir TW. Chemical ligation of unprotected peptides directly from a solid support. The Journal of Peptide Research : Official Journal of the American Peptide Society. 51: 303-16. PMID 9560006  1
1998 Camarero JA, Pavel J, Muir TW. Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization Angewandte Chemie - International Edition. 37: 347-349.  1
1997 Muir TW, Dawson PE, Fitzgerald MC, Kent SB. Protein signature analysis: a practical new approach for studying structure-activity relationships in peptides and proteins. Methods in Enzymology. 289: 545-64. PMID 9353737 DOI: 10.1016/S0076-6879(97)89063-5  1
1997 Muir TW, Dawson PE, Kent SB. Protein synthesis by chemical ligation of unprotected peptides in aqueous solution. Methods in Enzymology. 289: 266-98. PMID 9353726 DOI: 10.1016/S0076-6879(97)89052-0  1
1997 Love SG, Muir TW, Ramage R, Shaw KT, Alexeev D, Sawyer L, Kelly SM, Price NC, Arnold JE, Mee MP, Mayer RJ. Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids. The Biochemical Journal. 323: 727-34. PMID 9169606  1
1997 Dawson PE, Fitzgerald MC, Muir TW, Kent SBH. Methods for the chemical synthesis and readout of self-encoded arrays of polypeptide analogues Journal of the American Chemical Society. 119: 7917-7927. DOI: 10.1021/ja963122t  1
1997 Camarero JA, Muir TW. Chemoselective backbone cyclization of unprotected peptides Chemical Communications. 1369-1370.  1
1996 Muir TW, Dawson PE, Fitzgerald MC, Kent SB. Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis. Chemistry & Biology. 3: 817-25. PMID 8939700  1
1996 Zhao Y, Muir TW, Kent SB, Tischer E, Scardina JM, Chait BT. Mapping protein-protein interactions by affinity-directed mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 93: 4020-4. PMID 8633009 DOI: 10.1073/pnas.93.9.4020  1
1995 Muir TW. A chemical approach to the construction of multimeric protein assemblies. Structure (London, England : 1993). 3: 649-52. PMID 8591042 DOI: 10.1016/S0969-2126(01)00200-3  1
1995 Muir TW, Williams MJ, Kent SB. Detection of synthetic protein isomers and conformers by electrospray mass spectrometry. Analytical Biochemistry. 224: 100-9. PMID 7710055 DOI: 10.1006/abio.1995.1013  1
1995 Baca M, Muir TW, Schnölzer M, Kent SBH. Chemical ligation of cysteine-containing peptides: Synthesis of a 22 kDa tethered dimer of HIV-1 protease Journal of the American Chemical Society. 117: 1881-1887. DOI: 10.1021/ja00112a003  1
1994 Alexeev D, Bury SM, Turner MA, Ogunjobi OM, Muir TW, Ramage R, Sawyer L. Synthetic, structural and biological studies of the ubiquitin system: chemically synthesized and native ubiquitin fold into identical three-dimensional structures. The Biochemical Journal. 299: 159-63. PMID 8166634  1
1994 Ramage R, Green J, Muir TW, Ogunjobi OM, Love S, Shaw K. Synthetic, structural and biological studies of the ubiquitin system: the total chemical synthesis of ubiquitin. The Biochemical Journal. 299: 151-8. PMID 8166633  1
1994 Dawson PE, Muir TW, Clark-Lewis I, Kent SB. Synthesis of proteins by native chemical ligation. Science (New York, N.Y.). 266: 776-9. PMID 7973629  1
1994 Muir TW, Williams MJ, Ginsberg MH, Kent SB. Design and chemical synthesis of a neoprotein structural model for the cytoplasmic domain of a multisubunit cell-surface receptor: integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Biochemistry. 33: 7701-8. PMID 7516703  1
1994 Williams MJ, Muir TW, Ginsberg MH, Kent SBH. Total chemical synthesis of a folded β-sandwich protein domain: An analog of the tenth fibronectin type 3 module Journal of the American Chemical Society. 116: 10797-10798. DOI: 10.1021/ja00102a060  1
1993 Muir TW, Kent SB. The chemical synthesis of proteins. Current Opinion in Biotechnology. 4: 420-7. PMID 7763972 DOI: 10.1016/0958-1669(93)90007-J  1
1993 McLellan JF, McNab H, Muir TW. Ring expansion and rearrangement reactions of N-heteroarylmethyl radicals Journal of the Chemical Society, Chemical Communications. 839-840. DOI: 10.1039/C39930000839  1
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