Frederick M. Hughson - Publications

Affiliations: 
Molecular Biology Princeton University, Princeton, NJ 
Area:
intracellular trafficking in eukaryotes and cell-cell communication
Website:
http://www.princeton.edu/chemistry/faculty/associated/hughson/

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Travis SM, Kokona B, Fairman R, Hughson FM. Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering. Proceedings of the National Academy of Sciences of the United States of America. PMID 31712447 DOI: 10.1073/pnas.1909697116  0.6
2019 Brose N, Brunger A, Cafiso D, Chapman ER, Diao J, Hughson FM, Jackson MB, Jahn R, Lindau M, Ma C, Rizo J, Shin YK, Söllner TH, Tamm L, Yoon TY, et al. Synaptic vesicle fusion: today and beyond. Nature Structural & Molecular Biology. 26: 663-668. PMID 31384060 DOI: 10.1038/s41594-019-0277-z  0.4
2019 Paczkowski JE, McCready AR, Cong JP, Li Z, Jeffrey PD, Smith CD, Henke BR, Hughson FM, Bassler BL. An autoinducer analog reveals an alternative mode of ligand binding for the LasR quorum-sensing receptor. Acs Chemical Biology. PMID 30763066 DOI: 10.1021/acschembio.8b00971  0.72
2018 Jiao J, He M, Port SA, Baker RW, Xu Y, Qu H, Xiong Y, Wang Y, Jin H, Eisemann TJ, Hughson FM, Zhang Y. Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association. Elife. 7. PMID 30540253 DOI: 10.7554/eLife.41771  0.32
2016 Ha JY, Chou HT, Ungar D, Yip CK, Walz T, Hughson FM. Molecular architecture of the complete COG tethering complex. Nature Structural & Molecular Biology. PMID 27428773 DOI: 10.1038/nsmb.3263  1
2016 Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey PD, Semmelhack MF, Fairman R, Bassler BL, Hughson FM. Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. Plos Biology. 14: e1002464. PMID 27219477 DOI: 10.1371/journal.pbio.1002464  0.72
2015 Suckling RJ, Poon PP, Travis SM, Majoul IV, Hughson FM, Evans PR, Duden R, Owen DJ. Structural basis for the binding of tryptophan-based motifs by δ-COP. Proceedings of the National Academy of Sciences of the United States of America. 112: 14242-7. PMID 26578768 DOI: 10.1073/pnas.1506186112  1
2015 Baker RW, Jeffrey PD, Zick M, Phillips BP, Wickner WT, Hughson FM. A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly. Science (New York, N.Y.). 349: 1111-4. PMID 26339030 DOI: 10.1126/science.aac7906  1
2014 Ha JY, Pokrovskaya ID, Climer LK, Shimamura GR, Kudlyk T, Jeffrey PD, Lupashin VV, Hughson FM. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. Proceedings of the National Academy of Sciences of the United States of America. 111: 15762-7. PMID 25331899 DOI: 10.1073/pnas.1414829111  1
2014 Rogers JV, McMahon C, Baryshnikova A, Hughson FM, Rose MD. ER-associated retrograde SNAREs and the Dsl1 complex mediate an alternative, Sey1p-independent homotypic ER fusion pathway. Molecular Biology of the Cell. 25: 3401-12. PMID 25187651 DOI: 10.1091/mbc.E14-07-1220  1
2013 Bharucha N, Liu Y, Papanikou E, McMahon C, Esaki M, Jeffrey PD, Hughson FM, Glick BS. Sec16 influences transitional ER sites by regulating rather than organizing COPII. Molecular Biology of the Cell. 24: 3406-19. PMID 24006484 DOI: 10.1091/mbc.E13-04-0185  1
2013 Baker RW, Jeffrey PD, Hughson FM. Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16* Plos One. 8: e67409. PMID 23840694 DOI: 10.1371/journal.pone.0067409  1
2013 Hughson FM. Neuroscience. Chaperones that SNARE neurotransmitter release. Science (New York, N.Y.). 339: 406-7. PMID 23349281 DOI: 10.1126/science.1233801  1
2012 McMahon C, Studer SM, Clendinen C, Dann GP, Jeffrey PD, Hughson FM. The structure of Sec12 implicates potassium ion coordination in Sar1 activation. The Journal of Biological Chemistry. 287: 43599-606. PMID 23109340 DOI: 10.1074/jbc.M112.420141  1
2011 Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM. A strategy for antagonizing quorum sensing. Molecular Cell. 42: 199-209. PMID 21504831 DOI: 10.1016/j.molcel.2011.04.003  1
2010 Lees JA, Yip CK, Walz T, Hughson FM. Molecular organization of the COG vesicle tethering complex. Nature Structural & Molecular Biology. 17: 1292-7. PMID 20972446 DOI: 10.1038/nsmb.1917  1
2010 Hughson FM. Copy coats: COPI mimics clathrin and COPII. Cell. 142: 19-21. PMID 20603010 DOI: 10.1016/j.cell.2010.06.031  1
2010 Ren Q, Wimmer C, Chicka MC, Ye S, Ren Y, Hughson FM, Whiteheart SW. Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis. Blood. 116: 869-77. PMID 20435885 DOI: 10.1182/blood-2010-02-270934  0.72
2010 Hughson FM, Reinisch KM. Structure and mechanism in membrane trafficking. Current Opinion in Cell Biology. 22: 454-60. PMID 20418086 DOI: 10.1016/j.ceb.2010.03.011  1
2010 Yen WL, Shintani T, Nair U, Cao Y, Richardson BC, Li Z, Hughson FM, Baba M, Klionsky DJ. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. The Journal of Cell Biology. 188: 101-14. PMID 20065092 DOI: 10.1083/jcb.200904075  1
2010 Yu IM, Hughson FM. Tethering factors as organizers of intracellular vesicular traffic. Annual Review of Cell and Developmental Biology. 26: 137-56. PMID 19575650 DOI: 10.1146/annurev.cellbio.042308.113327  1
2009 Ren Y, Yip CK, Tripathi A, Huie D, Jeffrey PD, Walz T, Hughson FM. A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell. 139: 1119-29. PMID 20005805 DOI: 10.1016/j.cell.2009.11.002  1
2009 Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, Rabinowitz JD, Semmelhack MF, Hughson FM, Bassler BL. The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nature Chemical Biology. 5: 891-5. PMID 19838203 DOI: 10.1038/nchembio.237  1
2009 Richardson BC, Smith RD, Ungar D, Nakamura A, Jeffrey PD, Lupashin VV, Hughson FM. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proceedings of the National Academy of Sciences of the United States of America. 106: 13329-34. PMID 19651599 DOI: 10.1073/pnas.0901966106  1
2009 Tripathi A, Ren Y, Jeffrey PD, Hughson FM. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nature Structural & Molecular Biology. 16: 114-23. PMID 19151722 DOI: 10.1038/nsmb.1548  1
2008 Hughson FM. Both layers of the COPII coat come into view. Cell. 134: 384-5. PMID 18692460 DOI: 10.1016/j.cell.2008.07.027  1
2007 Neiditch MB, Hughson FM. The regulation of histidine sensor kinase complexes by quorum sensing signal molecules. Methods in Enzymology. 423: 250-63. PMID 17609135 DOI: 10.1016/S0076-6879(07)23011-3  1
2007 Cavanaugh LF, Chen X, Richardson BC, Ungar D, Pelczer I, Rizo J, Hughson FM. Structural analysis of conserved oligomeric Golgi complex subunit 2. The Journal of Biological Chemistry. 282: 23418-26. PMID 17565980 DOI: 10.1074/jbc.M703716200  1
2006 Togneri J, Cheng YS, Munson M, Hughson FM, Carr CM. Specific SNARE complex binding mode of the Sec1/Munc-18 protein, Sec1p. Proceedings of the National Academy of Sciences of the United States of America. 103: 17730-5. PMID 17090679 DOI: 10.1073/pnas.0605448103  1
2006 Neiditch MB, Federle MJ, Pompeani AJ, Kelly RC, Swem DL, Jeffrey PD, Bassler BL, Hughson FM. Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell. 126: 1095-108. PMID 16990134 DOI: 10.1016/j.cell.2006.07.032  1
2006 Ungar D, Oka T, Krieger M, Hughson FM. Retrograde transport on the COG railway. Trends in Cell Biology. 16: 113-20. PMID 16406524 DOI: 10.1016/j.tcb.2005.12.004  1
2005 Oka T, Vasile E, Penman M, Novina CD, Dykxhoorn DM, Ungar D, Hughson FM, Krieger M. Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells. The Journal of Biological Chemistry. 280: 32736-45. PMID 16051600 DOI: 10.1074/jbc.M505558200  1
2005 Ungar D, Oka T, Vasile E, Krieger M, Hughson FM. Subunit architecture of the conserved oligomeric Golgi complex. The Journal of Biological Chemistry. 280: 32729-35. PMID 16020545 DOI: 10.1074/jbc.M504590200  1
2005 Neiditch MB, Federle MJ, Miller ST, Bassler BL, Hughson FM. Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2. Molecular Cell. 18: 507-18. PMID 15916958 DOI: 10.1016/j.molcel.2005.04.020  1
2004 Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM. Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Molecular Cell. 15: 677-87. PMID 15350213 DOI: 10.1016/j.molcel.2004.07.020  1
2004 Oka T, Ungar D, Hughson FM, Krieger M. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. Molecular Biology of the Cell. 15: 2423-35. PMID 15004235 DOI: 10.1091/mbc.E03-09-0699  1
2003 Zweifel ME, Leahy DJ, Hughson FM, Barrick D. Structure and stability of the ankyrin domain of the Drosophila Notch receptor. Protein Science : a Publication of the Protein Society. 12: 2622-32. PMID 14573873 DOI: 10.1110/ps.03279003  1
2003 Ungar D, Hughson FM. SNARE protein structure and function. Annual Review of Cell and Developmental Biology. 19: 493-517. PMID 14570579 DOI: 10.1146/annurev.cellbio.19.110701.155609  1
2002 Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM. Structural identification of a bacterial quorum-sensing signal containing boron. Nature. 415: 545-9. PMID 11823863 DOI: 10.1038/415545a  1
2002 Barrick D, Hughson FM. Irreversible assembly of membrane fusion machines. Nature Structural Biology. 9: 78-80. PMID 11813007 DOI: 10.1038/nsb0202-78  1
2002 Munson M, Hughson FM. Conformational regulation of SNARE assembly and disassembly in vivo. The Journal of Biological Chemistry. 277: 9375-81. PMID 11777922 DOI: 10.1074/jbc.M111729200  1
2000 Waters MG, Hughson FM. Membrane tethering and fusion in the secretory and endocytic pathways. Traffic (Copenhagen, Denmark). 1: 588-97. PMID 11208146  1
2000 Munson M, Chen X, Cocina AE, Schultz SM, Hughson FM. Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly. Nature Structural Biology. 7: 894-902. PMID 11017200 DOI: 10.1038/79659  1
2000 Lerman JC, Robblee J, Fairman R, Hughson FM. Structural analysis of the neuronal SNARE protein syntaxin-1A. Biochemistry. 39: 8470-9. PMID 10913252 DOI: 10.1021/bi0003994  1
1999 Carr CM, Grote E, Munson M, Hughson FM, Novick PJ. Sec1p binds to SNARE complexes and concentrates at sites of secretion. The Journal of Cell Biology. 146: 333-44. PMID 10427089 DOI: 10.1083/jcb.146.2.333  1
1999 Hughson FM, Schedl P. Two domains and one RNA: a molecular threesome. Nature Structural Biology. 6: 499-502. PMID 10360345 DOI: 10.1038/9264  1
1999 Hughson FM. Membrane fusion: structure snared at last. Current Biology : Cb. 9: R49-52. PMID 10021356 DOI: 10.1016/S0960-9822(99)80008-6  1
1998 Nicholson KL, Munson M, Miller RB, Filip TJ, Fairman R, Hughson FM. Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p. Nature Structural Biology. 5: 793-802. PMID 9731774 DOI: 10.1038/1834  1
1997 Hughson FM. Enveloped viruses: a common mode of membrane fusion?. Current Biology : Cb. 7: R565-9. PMID 9285698  1
1997 Hughson FM. Penetrating insights into pore formation. Nature Structural Biology. 4: 89-92. PMID 9033582 DOI: 10.1038/nsb0297-89  1
1995 Skehel JJ, Bizebard T, Bullough PA, Hughson FM, Knossow M, Steinhauer DA, Wharton SA, Wiley DC. Membrane fusion by influenza hemagglutinin. Cold Spring Harbor Symposia On Quantitative Biology. 60: 573-80. PMID 8824430  1
1995 Chen J, Wharton SA, Weissenhorn W, Calder LJ, Hughson FM, Skehel JJ, Wiley DC. A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation. Proceedings of the National Academy of Sciences of the United States of America. 92: 12205-9. PMID 8618870 DOI: 10.1073/pnas.92.26.12205  1
1995 Hughson FM. Molecular mechanisms of protein-mediated membrane fusion. Current Opinion in Structural Biology. 5: 507-13. PMID 8528767 DOI: 10.1016/0959-440X(95)80036-0  1
1995 Hughson FM. Structural characterization of viral fusion proteins. Current Biology : Cb. 5: 265-74. PMID 7780737 DOI: 10.1016/S0960-9822(95)00057-1  1
1994 Barrick D, Hughson FM, Baldwin RL. Molecular mechanisms of acid denaturation. The role of histidine residues in the partial unfolding of apomyoglobin. Journal of Molecular Biology. 237: 588-601. PMID 8158639 DOI: 10.1006/jmbi.1994.1257  1
1994 Bullough PA, Hughson FM, Treharne AC, Ruigrok RW, Skehel JJ, Wiley DC. Crystals of a fragment of influenza haemagglutinin in the low pH induced conformation. Journal of Molecular Biology. 236: 1262-5. PMID 8120902 DOI: 10.1016/0022-2836(94)90027-2  1
1994 Bullough PA, Hughson FM, Skehel JJ, Wiley DC. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature. 371: 37-43. PMID 8072525 DOI: 10.1038/371037a0  1
1991 Hughson FM, Barrick D, Baldwin RL. Probing the stability of a partly folded apomyoglobin intermediate by site-directed mutagenesis. Biochemistry. 30: 4113-8. PMID 2021603  1
1990 Hughson FM, Wright PE, Baldwin RL. Structural characterization of a partly folded apomyoglobin intermediate. Science (New York, N.Y.). 249: 1544-8. PMID 2218495  1
1989 Hughson FM, Baldwin RL. Use of site-directed mutagenesis to destabilize native apomyoglobin relative to folding intermediates. Biochemistry. 28: 4415-22. PMID 2765493  1
1984 Weinert TA, Derbyshire KM, Hughson FM, Grindley ND. Replicative and conservative transpositional recombination of insertion sequences. Cold Spring Harbor Symposia On Quantitative Biology. 49: 251-60. PMID 6099240  1
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