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Manuel Llinás - Publications

Affiliations: 
Molecular Biology Princeton University, Princeton, NJ 
Website:
http://www.princeton.edu/chemistry/faculty/associated/llinas/

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Cobbold SA, Llinás M, Kirk K. Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum. Cellular Microbiology. PMID 26633083 DOI: 10.1111/cmi.12552  0.96
2015 Ochoa A, Storey JD, Llinás M, Singh M. Beyond the E-Value: Stratified Statistics for Protein Domain Prediction. Plos Computational Biology. 11: e1004509. PMID 26575353 DOI: 10.1371/journal.pcbi.1004509  0.96
2015 Pulcini S, Staines HM, Lee AH, Shafik SH, Bouyer G, Moore CM, Daley DA, Hoke MJ, Altenhofen LM, Painter HJ, Mu J, Ferguson DJ, Llinás M, Martin RE, Fidock DA, et al. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities. Scientific Reports. 5: 14552. PMID 26420308 DOI: 10.1038/srep14552  0.96
2015 Ke H, Lewis IA, Morrisey JM, McLean KJ, Ganesan SM, Painter HJ, Mather MW, Jacobs-Lorena M, Llinás M, Vaidya AB. Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle. Cell Reports. 11: 164-74. PMID 25843709 DOI: 10.1016/j.celrep.2015.03.011  0.96
2015 Eshar S, Altenhofen L, Rabner A, Ross P, Fastman Y, Mandel-Gutfreund Y, Karni R, Llinás M, Dzikowski R. PfSR1 controls alternative splicing and steady-state RNA levels in Plasmodium falciparum through preferential recognition of specific RNA motifs. Molecular Microbiology. 96: 1283-97. PMID 25807998 DOI: 10.1111/mmi.13007  0.96
2015 Adjalley SH, Scanfeld D, Kozlowski E, Llinás M, Fidock DA. Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1 Bmc Genomics. 16. DOI: 10.1186/s12864-015-2320-8  0.96
2015 Josling GA, Llinás M. Sexual development in Plasmodium parasites: Knowing when it's time to commit Nature Reviews Microbiology. 13: 573-587. DOI: 10.1038/nrmicro3519  0.96
2014 Lisewski AM, Quiros JP, Ng CL, Adikesavan AK, Miura K, Putluri N, Eastman RT, Scanfeld D, Regenbogen SJ, Altenhofen L, Llinás M, Sreekumar A, Long C, Fidock DA, Lichtarge O. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell. 158: 916-28. PMID 25126794 DOI: 10.1016/j.cell.2014.07.011  0.96
2014 Coleman BI, Skillman KM, Jiang RH, Childs LM, Altenhofen LM, Ganter M, Leung Y, Goldowitz I, Kafsack BF, Marti M, Llinás M, Buckee CO, Duraisingh MT. A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. Cell Host & Microbe. 16: 177-86. PMID 25121747 DOI: 10.1016/j.chom.2014.06.014  0.96
2014 Oberstaller J, Pumpalova Y, Schieler A, Llinás M, Kissinger JC. The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems. Nucleic Acids Research. 42: 8271-84. PMID 24957599 DOI: 10.1093/nar/gku500  0.96
2014 O'Hara JK, Kerwin LJ, Cobbold SA, Tai J, Bedell TA, Reider PJ, Llinás M. Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. Plos One. 9: e94061. PMID 24747974 DOI: 10.1371/journal.pone.0094061  0.96
2014 Kafsack BF, Rovira-Graells N, Clark TG, Bancells C, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA, Cortés A, Llinás M. A transcriptional switch underlies commitment to sexual development in malaria parasites. Nature. 507: 248-52. PMID 24572369 DOI: 10.1038/nature12920  0.96
2014 Sinha A, Hughes KR, Modrzynska KK, Otto TD, Pfander C, Dickens NJ, Religa AA, Bushell E, Graham AL, Cameron R, Kafsack BF, Williams AE, Llinás M, Berriman M, Billker O, et al. A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. Nature. 507: 253-7. PMID 24572359 DOI: 10.1038/nature12970  0.96
2014 Lewis IA, Wacker M, Olszewski KL, Cobbold SA, Baska KS, Tan A, Ferdig MT, Llinás M. Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism. Plos Genetics. 10: e1004085. PMID 24391526 DOI: 10.1371/journal.pgen.1004085  0.96
2014 Klein EY, Graham AL, Llinás M, Levin S. Cross-reactive immune responses as primary drivers of malaria chronicity. Infection and Immunity. 82: 140-51. PMID 24126530 DOI: 10.1128/IAI.00958-13  0.96
2013 Cobbold SA, Vaughan AM, Lewis IA, Painter HJ, Camargo N, Perlman DH, Fishbaugher M, Healer J, Cowman AF, Kappe SH, Llinás M. Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum. The Journal of Biological Chemistry. 288: 36338-50. PMID 24163372 DOI: 10.1074/jbc.M113.503557  0.96
2013 Caudy AA, Guan Y, Jia Y, Hansen C, DeSevo C, Hayes AP, Agee J, Alvarez-Dominguez JR, Arellano H, Barrett D, Bauerle C, Bisaria N, Bradley PH, Breunig JS, Bush E, et al. A new system for comparative functional genomics of Saccharomyces yeasts. Genetics. 195: 275-87. PMID 23852385 DOI: 10.1534/genetics.113.152918  0.96
2013 Mira-Martínez S, Rovira-Graells N, Crowley VM, Altenhofen LM, Llinás M, Cortés A. Epigenetic switches in clag3 genes mediate blasticidin S resistance in malaria parasites. Cellular Microbiology. 15: 1913-23. PMID 23819786 DOI: 10.1111/cmi.12162  0.96
2013 Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Retraction: Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature. 497: 652. PMID 23615611 DOI: 10.1038/nature12164  0.96
2013 Radke JB, Lucas O, De Silva EK, Ma Y, Sullivan WJ, Weiss LM, Llinas M, White MW. ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst. Proceedings of the National Academy of Sciences of the United States of America. 110: 6871-6. PMID 23572590 DOI: 10.1073/pnas.1300059110  0.36
2013 Olszewski KL, Llinás M. Extraction of hydrophilic metabolites from Plasmodium falciparum-infected erythrocytes for metabolomic analysis. Methods in Molecular Biology (Clifton, N.J.). 923: 259-66. PMID 22990783 DOI: 10.1007/978-1-62703-026-7_17  0.96
2013 Painter HJ, Altenhofen LM, Kafsack BF, Llinás M. Whole-genome analysis of Plasmodium spp. Utilizing a new agilent technologies DNA microarray platform. Methods in Molecular Biology (Clifton, N.J.). 923: 213-9. PMID 22990780 DOI: 10.1007/978-1-62703-026-7_14  0.96
2013 Olszewski KL, Llinás M. Extraction of hydrophilic metabolites from plasmodium falciparum -infected erythrocytes for metabolomic analysis Methods in Molecular Biology. 923: 259-266. DOI: 10.1007/978-1-62703-26-7_17  0.96
2012 Pino P, Sebastian S, Kim EA, Bush E, Brochet M, Volkmann K, Kozlowski E, Llinás M, Billker O, Soldati-Favre D. A tetracycline-repressible transactivator system to study essential genes in malaria parasites. Cell Host & Microbe. 12: 824-34. PMID 23245327 DOI: 10.1016/j.chom.2012.10.016  0.96
2012 Babbitt SE, Altenhofen L, Cobbold SA, Istvan ES, Fennell C, Doerig C, Llinás M, Goldberg DE. Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state. Proceedings of the National Academy of Sciences of the United States of America. 109: E3278-87. PMID 23112171 DOI: 10.1073/pnas.1209823109  0.96
2012 Straimer J, Lee MC, Lee AH, Zeitler B, Williams AE, Pearl JR, Zhang L, Rebar EJ, Gregory PD, Llinás M, Urnov FD, Fidock DA. Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases. Nature Methods. 9: 993-8. PMID 22922501 DOI: 10.1038/nmeth.2143  0.96
2012 Kafsack BF, Painter HJ, Llinás M. New Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research community. Malaria Journal. 11: 187. PMID 22681930 DOI: 10.1186/1475-2875-11-187  0.96
2012 Painter HJ, Llinás M. Comment on "Emerging functions of transcription factors in malaria parasite". Journal of Biomedicine & Biotechnology. 2012: 754054. PMID 22675258 DOI: 10.1155/2012/754054  0.96
2012 Klein EY, Lewis IA, Jung C, Llinás M, Levin SA. Relationship between treatment-seeking behaviour and artemisinin drug quality in Ghana. Malaria Journal. 11: 110. PMID 22482747 DOI: 10.1186/1475-2875-11-110  0.96
2011 Lindner SE, Llinás M, Keck JL, Kappe SH. The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast. Molecular and Biochemical Parasitology. 180: 69-75. PMID 21856338 DOI: 10.1016/j.molbiopara.2011.08.002  0.96
2011 Ochoa A, Llinás M, Singh M. Using context to improve protein domain identification. Bmc Bioinformatics. 12: 90. PMID 21453511 DOI: 10.1186/1471-2105-12-90  0.96
2011 Painter HJ, Campbell TL, Llinás M. The Apicomplexan AP2 family: integral factors regulating Plasmodium development. Molecular and Biochemical Parasitology. 176: 1-7. PMID 21126543 DOI: 10.1016/j.molbiopara.2010.11.014  0.96
2011 Olszewski KL, Llinás M. Central carbon metabolism of Plasmodium parasites. Molecular and Biochemical Parasitology. 175: 95-103. PMID 20849882 DOI: 10.1016/j.molbiopara.2010.09.001  0.96
2010 Campbell TL, De Silva EK, Olszewski KL, Elemento O, Llinás M. Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. Plos Pathogens. 6: e1001165. PMID 21060817 DOI: 10.1371/journal.ppat.1001165  0.96
2010 Plata G, Hsiao TL, Olszewski KL, Llinás M, Vitkup D. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Molecular Systems Biology. 6: 408. PMID 20823846 DOI: 10.1038/msb.2010.60  0.96
2010 Olszewski KL, Mather MW, Morrisey JM, Garcia BA, Vaidya AB, Rabinowitz JD, Llinás M. Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature. 466: 774-8. PMID 20686576 DOI: 10.1038/nature09301  0.96
2010 Dowling DP, Ilies M, Olszewski KL, Portugal S, Mota MM, Llinás M, Christianson DW. Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection . Biochemistry. 49: 5600-8. PMID 20527960 DOI: 10.1021/bi100390z  0.96
2010 Kafsack BF, Llinás M. Eating at the table of another: metabolomics of host-parasite interactions. Cell Host & Microbe. 7: 90-9. PMID 20159614 DOI: 10.1016/j.chom.2010.01.008  0.96
2010 Otto TD, Wilinski D, Assefa S, Keane TM, Sarry LR, Böhme U, Lemieux J, Barrell B, Pain A, Berriman M, Newbold C, Llinás M. New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. Molecular Microbiology. 76: 12-24. PMID 20141604 DOI: 10.1111/j.1365-2958.2009.07026.x  0.96
2010 Lindner SE, De Silva EK, Keck JL, Llinás M. Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator. Journal of Molecular Biology. 395: 558-67. PMID 19913037 DOI: 10.1016/j.jmb.2009.11.004  0.96
2009 Battistel MD, Grishaev A, An SS, Castellino FJ, Llinás M. Solution structure and functional characterization of human plasminogen kringle 5. Biochemistry. 48: 10208-19. PMID 19821587 DOI: 10.1021/bi901433n  0.4
2009 Howitt CA, Wilinski D, Llinás M, Templeton TJ, Dzikowski R, Deitsch KW. Clonally variant gene families in Plasmodium falciparum share a common activation factor. Molecular Microbiology. 73: 1171-85. PMID 19708920 DOI: 10.1111/j.1365-2958.2009.06846.x  0.96
2009 Zawada RJ, Kwan P, Olszewski KL, Llinas M, Huang SG. Quantitative determination of urea concentrations in cell culture medium. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 87: 541-4. PMID 19448747 DOI: 10.1139/o09-011  0.96
2009 Olszewski KL, Morrisey JM, Wilinski D, Burns JM, Vaidya AB, Rabinowitz JD, Llinás M. Host-parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host & Microbe. 5: 191-9. PMID 19218089 DOI: 10.1016/j.chom.2009.01.004  0.96
2009 van Brummelen AC, Olszewski KL, Wilinski D, Llinás M, Louw AI, Birkholtz LM. Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses. The Journal of Biological Chemistry. 284: 4635-46. PMID 19073607 DOI: 10.1074/jbc.M807085200  0.96
2008 Llinás M, Deitsch KW, Voss TS. Plasmodium gene regulation: far more to factor in. Trends in Parasitology. 24: 551-6. PMID 18929512 DOI: 10.1016/j.pt.2008.08.010  0.96
2008 Tamez PA, Bhattacharjee S, van Ooij C, Hiller NL, Llinás M, Balu B, Adams JH, Haldar K. An erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surface. Plos Pathogens. 4: e1000118. PMID 18688278 DOI: 10.1371/journal.ppat.1000118  0.96
2008 De Silva EK, Gehrke AR, Olszewski K, León I, Chahal JS, Bulyk ML, Llinás M. Specific DNA-binding by apicomplexan AP2 transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 105: 8393-8. PMID 18541913 DOI: 10.1073/pnas.0801993105  0.96
2008 Birkholtz L, van Brummelen AC, Clark K, Niemand J, Maréchal E, Llinás M, Louw AI. Exploring functional genomics for drug target and therapeutics discovery in Plasmodia. Acta Tropica. 105: 113-23. PMID 18083131 DOI: 10.1016/j.actatropica.2007.10.013  0.96
2007 Hu G, Llinás M, Li J, Preiser PR, Bozdech Z. Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy. Bmc Bioinformatics. 8: 350. PMID 17880708 DOI: 10.1186/1471-2105-8-350  0.96
2007 Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. Mechanisms of gene regulation in Plasmodium. The American Journal of Tropical Medicine and Hygiene. 77: 201-8. PMID 17690387  0.96
2007 Cellitti J, Llinas M, Echols N, Shank EA, Gillespie B, Kwon E, Crowder SM, Dahlquist FW, Alber T, Marqusee S. Exploring subdomain cooperativity in T4 lysozyme I: structural and energetic studies of a circular permutant and protein fragment. Protein Science : a Publication of the Protein Society. 16: 842-51. PMID 17400926 DOI: 10.1110/ps.062628607  0.72
2006 Llinás M, Bozdech Z, Wong ED, Adai AT, DeRisi JL. Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains. Nucleic Acids Research. 34: 1166-73. PMID 16493140 DOI: 10.1093/nar/gkj517  0.96
2005 Llinás M, del Portillo HA. Mining the malaria transcriptome. Trends in Parasitology. 21: 350-2. PMID 15979411 DOI: 10.1016/j.pt.2005.06.009  0.96
2004 Galgoczy DJ, Cassidy-Stone A, Llinás M, O'Rourke SM, Herskowitz I, DeRisi JL, Johnson AD. Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 101: 18069-74. PMID 15604142 DOI: 10.1073/pnas.0407611102  0.96
2004 Llinás M, DeRisi JL. Pernicious plans revealed: Plasmodium falciparum genome wide expression analysis. Current Opinion in Microbiology. 7: 382-7. PMID 15358256 DOI: 10.1016/j.mib.2004.06.014  0.96
2004 Grishaev A, Llinás M. BACUS: A Bayesian protocol for the identification of protein NOESY spectra via unassigned spin systems. Journal of Biomolecular Nmr. 28: 1-10. PMID 14739635 DOI: 10.1023/B:JNMR.0000012846.56763.f7  0.4
2003 Bozdech Z, Llinás M, Pulliam BL, Wong ED, Zhu J, DeRisi JL. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. Plos Biology. 1: E5. PMID 12929205 DOI: 10.1371/journal.pbio.0000005  0.96
1999 Llinás M, Gillespie B, Dahlquist FW, Marqusee S. The energetics of T4 lysozyme reveal a hierarchy of conformations. Nature Structural Biology. 6: 1072-8. PMID 10542101 DOI: 10.1038/14956  0.72
1999 Liu H, Farr-Jones S, Ulyanov NB, Llinas M, Marqusee S, Groth D, Cohen FE, Prusiner SB, James TL. Solution structure of Syrian hamster prion protein rPrP(90-231). Biochemistry. 38: 5362-77. PMID 10220323 DOI: 10.1021/bi982878x  0.96
1998 Llinás M, Marqusee S. Subdomain interactions as a determinant in the folding and stability of T4 lysozyme. Protein Science : a Publication of the Protein Society. 7: 96-104. PMID 9514264 DOI: 10.1002/pro.5560070110  0.96
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