David Cowburn - Publications

Rockefeller University, New York, NY, United States 
 New York Structural Biology Center 
 Albert Einstein College of Medicine, New York, New York, United States 

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Stevens AJ, Sekar G, Gramespacher JA, Cowburn D, Muir TW. An Atypical Mechanism of Split Intein Molecular Recognition and Folding. Journal of the American Chemical Society. PMID 30156841 DOI: 10.1021/jacs.8b07334  1
2018 Sparks S, Temel DB, Rout MP, Cowburn D. Deciphering the "Fuzzy" Interaction of FG Nucleoporins and Transport Factors Using Small-Angle Neutron Scattering. Structure (London, England : 1993). PMID 29429880 DOI: 10.1016/j.str.2018.01.010  1
2018 Hayama R, Sparks S, Hecht LM, Dutta K, Cabana CM, Karp JM, Rout MP, Cowburn D. Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex. The Journal of Biological Chemistry. PMID 29374059 DOI: 10.1074/jbc.AC117.001649  1
2017 Warren C, Matsui T, Karp JM, Onikubo T, Cahill S, Brenowitz M, Cowburn D, Girvin M, Shechter D. Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release. Nature Communications. 8: 2215. PMID 29263320 DOI: 10.1038/s41467-017-02308-3  1
2017 Stevens AJ, Sekar G, Shah NH, Mostafavi AZ, Cowburn D, Muir TW. A promiscuous split intein with expanded protein engineering applications. Proceedings of the National Academy of Sciences of the United States of America. PMID 28739907 DOI: 10.1073/pnas.1701083114  1
2017 Upla P, Kim SJ, Sampathkumar P, Dutta K, Cahill SM, Chemmama IE, Williams R, Bonanno JB, Rice WJ, Stokes DL, Cowburn D, Almo SC, Sali A, Rout MP, Fernandez-Martinez J. Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex. Structure (London, England : 1993). PMID 28162953 DOI: 10.1016/j.str.2017.01.006  1
2017 Karp JM, Sparks S, Cowburn D. Effects of FGFR2 kinase activation loop dynamics on catalytic activity. Plos Computational Biology. 13: e1005360. PMID 28151998 DOI: 10.1371/journal.pcbi.1005360  1
2017 Liu D, Cowburn D. Segmental Isotopic Labeling of Proteins for NMR Study Using Intein Technology. Methods in Molecular Biology (Clifton, N.J.). 1495: 131-145. PMID 27714614 DOI: 10.1007/978-1-4939-6451-2_9  1
2016 Liu D, Cowburn D. Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophysics Reports. 2: 33-43. PMID 27819029 DOI: 10.1007/s41048-016-0025-4  1
2016 Liu D, Yuan Y, Xu R, Cowburn D. Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling. Protein & Cell. PMID 27815825 DOI: 10.1007/s13238-016-0333-y  1
2016 Raveh B, Karp JM, Sparks S, Dutta K, Rout MP, Sali A, Cowburn D. Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 27091992 DOI: 10.1073/pnas.1522663113  1
2016 Stevens AJ, Brown ZZ, Shah NH, Sekar G, Cowburn D, Muir TW. Design of a Split Intein with Exceptional Protein Splicing Activity. Journal of the American Chemical Society. PMID 26854538 DOI: 10.1021/jacs.5b13528  1
2015 Ferrage F, Dutta K, Cowburn D. Identification of Hydrophobic Interfaces in Protein-Ligand Complexes by Selective Saturation Transfer NMR Spectroscopy. Molecules (Basel, Switzerland). 20: 21992-9. PMID 26690112 DOI: 10.3390/molecules201219824  1
2015 Xia Y, Eryilmaz E, Zhang Q, Cowburn D, Putterman C. Anti-DNA antibody mediated catalysis is isotype dependent. Molecular Immunology. 69: 33-43. PMID 26655427 DOI: 10.1016/j.molimm.2015.11.001  1
2015 Hough LE, Dutta K, Sparks S, Temel DB, Kamal A, Tetenbaum-Novatt J, Rout MP, Cowburn D. The molecular mechanism of nuclear transport revealed by atomic-scale measurements. Elife. 4. PMID 26371551 DOI: 10.7554/eLife.10027  1
2015 Karp JM, Eryilmaz E, Cowburn D. Erratum to: Correlation of chemical shifts predicted by molecular dynamics simulations for partially disordered proteins. Journal of Biomolecular Nmr. 62: 119. PMID 25749870 DOI: 10.1007/s10858-015-9915-x  1
2015 Wilner SE, Sparks SE, Cowburn D, Girvin ME, Levy M. Controlling lipid micelle stability using oligonucleotide headgroups. Journal of the American Chemical Society. 137: 2171-4. PMID 25634639 DOI: 10.1021/ja512012m  1
2015 Karp JM, Erylimaz E, Cowburn D. Correlation of chemical shifts predicted by molecular dynamics simulations for partially disordered proteins. Journal of Biomolecular Nmr. 61: 35-45. PMID 25416617 DOI: 10.1007/s10858-014-9879-2  1
2014 Eryilmaz E, Shah NH, Muir TW, Cowburn D. Structural and dynamical features of inteins and implications on protein splicing. The Journal of Biological Chemistry. 289: 14506-11. PMID 24695731 DOI: 10.1074/jbc.R113.540302  1
2013 Shah NH, Eryilmaz E, Cowburn D, Muir TW. Naturally split inteins assemble through a "capture and collapse" mechanism. Journal of the American Chemical Society. 135: 18673-81. PMID 24236406 DOI: 10.1021/ja4104364  1
2013 Eryilmaz E, Janda A, Kim J, Cordero RJ, Cowburn D, Casadevall A. Global structures of IgG isotypes expressing identical variable regions. Molecular Immunology. 56: 588-98. PMID 23911417 DOI: 10.1016/j.molimm.2013.06.006  1
2013 Chen H, Huang Z, Dutta K, Blais S, Neubert TA, Li X, Cowburn D, Traaseth NJ, Mohammadi M. Cracking the molecular origin of intrinsic tyrosine kinase activity through analysis of pathogenic gain-of-function mutations. Cell Reports. 4: 376-84. PMID 23871672 DOI: 10.1016/j.celrep.2013.06.025  1
2013 Bhattacharya S, Ju JH, Orlova N, Khajeh JA, Cowburn D, Bu Z. Ligand-induced dynamic changes in extended PDZ domains from NHERF1. Journal of Molecular Biology. 425: 2509-28. PMID 23583913 DOI: 10.1016/j.jmb.2013.04.001  1
2013 Shah NH, Eryilmaz E, Cowburn D, Muir TW. Extein residues play an intimate role in the rate-limiting step of protein trans-splicing. Journal of the American Chemical Society. 135: 5839-47. PMID 23506399 DOI: 10.1021/ja401015p  1
2012 Cucuringu M, Singer A, Cowburn D. Eigenvector synchronization, graph rigidity and the molecule problem. Information and Inference : a Journal of the Ima. 1: 21. PMID 24432187  1
2012 Janda A, Eryilmaz E, Nakouzi A, Cowburn D, Casadevall A. Variable region identical immunoglobulins differing in isotype express different paratopes. The Journal of Biological Chemistry. 287: 35409-17. PMID 22930758 DOI: 10.1074/jbc.M112.404483  1
2012 Xu R, Liu D, Cowburn D. Abl kinase constructs expressed in bacteria: facilitation of structural and functional studies including segmental labeling by expressed protein ligation. Molecular Biosystems. 8: 1878-85. PMID 22592215 DOI: 10.1039/c2mb25051a  1
2012 Kalinina J, Dutta K, Ilghari D, Beenken A, Goetz R, Eliseenkova AV, Cowburn D, Mohammadi M. The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition. Structure (London, England : 1993). 20: 77-88. PMID 22244757 DOI: 10.1016/j.str.2011.10.022  1
2012 Bhattacharya S, Zhang H, Cowburn D, Debnath AK. Novel structures of self-associating stapled peptides. Biopolymers. 97: 253-64. PMID 22170623 DOI: 10.1002/bip.22015  1
2012 Piserchio A, Cowburn D, Ghose R. Expression and purification of Src-family kinases for solution NMR studies. Methods in Molecular Biology (Clifton, N.J.). 831: 111-31. PMID 22167671 DOI: 10.1007/978-1-61779-480-3_7  1
2011 Zhang H, Curreli F, Zhang X, Bhattacharya S, Waheed AA, Cooper A, Cowburn D, Freed EO, Debnath AK. Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain. Retrovirology. 8: 28. PMID 21539734 DOI: 10.1186/1742-4690-8-28  1
2011 Zhao F, Ilbert M, Varadan R, Cremers CM, Hoyos B, Acin-Perez R, Vinogradov V, Cowburn D, Jakob U, Hammerling U. Are zinc-finger domains of protein kinase C dynamic structures that unfold by lipid or redox activation? Antioxidants & Redox Signaling. 14: 757-66. PMID 21067413 DOI: 10.1089/ars.2010.3773  1
2010 Ferrage F, Reichel A, Battacharya S, Cowburn D, Ghose R. On the measurement of ¹⁵N-{¹H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 207: 294-303. PMID 20951618 DOI: 10.1016/j.jmr.2010.09.014  1
2010 Tait S, Dutta K, Cowburn D, Warwicker J, Doig AJ, McCarthy JE. Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E. Proceedings of the National Academy of Sciences of the United States of America. 107: 17627-32. PMID 20880835 DOI: 10.1073/pnas.1008242107  1
2010 Nicholas MP, Eryilmaz E, Ferrage F, Cowburn D, Ghose R. Nuclear spin relaxation in isotropic and anisotropic media. Progress in Nuclear Magnetic Resonance Spectroscopy. 57: 111-58. PMID 20633361 DOI: 10.1016/j.pnmrs.2010.04.003  1
2010 Frutos S, Goger M, Giovani B, Cowburn D, Muir TW. Branched intermediate formation stimulates peptide bond cleavage in protein splicing. Nature Chemical Biology. 6: 527-33. PMID 20495572 DOI: 10.1038/nchembio.371  1
2010 Ferrage F, Dutta K, Shekhtman A, Cowburn D. Structural determination of biomolecular interfaces by nuclear magnetic resonance of proteins with reduced proton density. Journal of Biomolecular Nmr. 47: 41-54. PMID 20372977 DOI: 10.1007/s10858-010-9409-9  1
2010 Bhattacharya S, Dai Z, Li J, Baxter S, Callaway DJE, Cowburn D, Bu Z. A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation Journal of Biological Chemistry. 285: 9981-9994. PMID 20042604 DOI: 10.1074/jbc.M109.074005  1
2009 Liu D, Xu R, Cowburn D. Segmental isotopic labeling of proteins for nuclear magnetic resonance. Methods in Enzymology. 462: 151-75. PMID 19632474 DOI: 10.1016/S0076-6879(09)62008-5  1
2009 Piserchio A, Ghose R, Cowburn D. Optimized bacterial expression and purification of the c-Src catalytic domain for solution NMR studies. Journal of Biomolecular Nmr. 44: 87-93. PMID 19399371 DOI: 10.1007/s10858-009-9318-y  1
2009 Ferrage F, Cowburn D, Ghose R. Accurate sampling of high-frequency motions in proteins by steady-state (15)N-{(1)H} nuclear Overhauser effect measurements in the presence of cross-correlated relaxation. Journal of the American Chemical Society. 131: 6048-9. PMID 19358609 DOI: 10.1021/ja809526q  1
2008 Pellecchia M, Bertini I, Cowburn D, Dalvit C, Giralt E, Jahnke W, James TL, Homans SW, Kessler H, Luchinat C, Meyer B, Oschkinat H, Peng J, Schwalbe H, Siegal G. Perspectives on NMR in drug discovery: a technique comes of age. Nature Reviews. Drug Discovery. 7: 738-45. PMID 19172689 DOI: 10.1038/nrd2606  1
2008 Schwartz EC, Shekhtman A, Dutta K, Pratt MR, Cowburn D, Darst S, Muir TW. A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding. Chemistry & Biology. 15: 1091-103. PMID 18940669 DOI: 10.1016/j.chembiol.2008.09.008  1
2008 Bhattacharya S, Zhang H, Debnath AK, Cowburn D. Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid. The Journal of Biological Chemistry. 283: 16274-8. PMID 18417468 DOI: 10.1074/jbc.C800048200  1
2008 Ferrage F, Piserchio A, Cowburn D, Ghose R. On the measurement of 15N-{1H} nuclear Overhauser effects. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 192: 302-13. PMID 18417394 DOI: 10.1016/j.jmr.2008.03.011  1
2008 Zhang H, Zhao Q, Bhattacharya S, Waheed AA, Tong X, Hong A, Heck S, Curreli F, Goger M, Cowburn D, Freed EO, Debnath AK. A cell-penetrating helical peptide as a potential HIV-1 inhibitor. Journal of Molecular Biology. 378: 565-80. PMID 18374356 DOI: 10.1016/j.jmb.2008.02.066  1
2008 Liu D, Xu R, Dutta K, Cowburn D. N-terminal cysteinyl proteins can be prepared using thrombin cleavage. Febs Letters. 582: 1163-7. PMID 18331839 DOI: 10.1016/j.febslet.2008.02.078  1
2008 Xiong X, Cui P, Hossain S, Xu R, Warner B, Guo X, An X, Debnath AK, Cowburn D, Kotula L. Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1. Biochimica Et Biophysica Acta. 1783: 737-47. PMID 18328268 DOI: 10.1016/j.bbamcr.2008.01.028  1
2007 Cowburn D. Moving parts: how the adaptor protein CRK is regulated, and regulates. Nature Structural & Molecular Biology. 14: 465-6. PMID 17549081 DOI: 10.1038/nsmb0607-465  0.01
2007 Valentine ER, Ferrage F, Massi F, Cowburn D, Palmer AG. Joint composite-rotation adiabatic-sweep isotope filtration. Journal of Biomolecular Nmr. 38: 11-22. PMID 17353973 DOI: 10.1007/s10858-006-9131-9  1
2006 Burz DS, Dutta K, Cowburn D, Shekhtman A. In-cell NMR for protein-protein interactions (STINT-NMR). Nature Protocols. 1: 146-52. PMID 17406226 DOI: 10.1038/nprot.2006.23  1
2006 Ferrage F, Pelupessy P, Cowburn D, Bodenhausen G. Protein backbone dynamics through 13C′-13C α cross-relaxation in NMR spectroscopy Journal of the American Chemical Society. 128: 11072-11078. PMID 16925424 DOI: 10.1021/ja0600577  1
2006 Muralidharan V, Dutta K, Cho J, Vila-Perello M, Raleigh DP, Cowburn D, Muir TW. Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II. Biochemistry. 45: 8874-84. PMID 16846230 DOI: 10.1021/bi060590z  1
2006 Ji H, Shekhtman A, Ghose R, McDonnell JM, Cowburn D. NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL. Magnetic Resonance in Chemistry : Mrc. 44: S101-7. PMID 16826547 DOI: 10.1002/mrc.1856  1
2006 Mukherjee M, Dutta K, White MA, Cowburn D, Fox RO. NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition. Protein Science : a Publication of the Protein Society. 15: 1342-55. PMID 16731969 DOI: 10.1110/ps.051844006  1
2006 Burz DS, Dutta K, Cowburn D, Shekhtman A. Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR). Nature Methods. 3: 91-3. PMID 16432517 DOI: 10.1038/nmeth851  1
2004 Cowburn D, Shekhtman A, Xu R, Ottesen JJ, Muir TW. Segmental isotopic labeling for structural biological applications of NMR. Methods in Molecular Biology (Clifton, N.J.). 278: 47-56. PMID 15317990 DOI: 10.1385/1-59259-809-9:047  1
2004 Romanelli A, Shekhtman A, Cowburn D, Muir TW. Semisynthesis of a segmental isotopically labeled protein splicing precursor: NMR evidence for an unusual peptide bond at the N-extein-intein junction. Proceedings of the National Academy of Sciences of the United States of America. 101: 6397-402. PMID 15087498 DOI: 10.1073/pnas.0306616101  1
2002 Shekhtman A, Cowburn D. A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins. Biochemical and Biophysical Research Communications. 296: 1222-7. PMID 12207904 DOI: 10.1016/S0006-291X(02)02006-5  1
2002 Shekhtman A, Ghose R, Goger M, Cowburn D. NMR structure determination and investigation using a reduced proton (REDPRO) labeling strategy for proteins. Febs Letters. 524: 177-82. PMID 12135763 DOI: 10.1016/S0014-5793(02)03051-X  1
2002 Camarero JA, Shekhtman A, Campbell EA, Chlenov M, Gruber TM, Bryant DA, Darst SA, Cowburn D, Muir TW. Autoregulation of a bacterial sigma factor explored by using segmental isotopic labeling and NMR. Proceedings of the National Academy of Sciences of the United States of America. 99: 8536-41. PMID 12084914 DOI: 10.1073/pnas.132033899  1
2001 Shekhtman A, Ghose R, Wang D, Cole PA, Cowburn D. Novel mechanism of regulation of the non-receptor protein tyrosine kinase Csk: insights from NMR mapping studies and site-directed mutagenesis. Journal of Molecular Biology. 314: 129-38. PMID 11724538 DOI: 10.1006/jmbi.2001.5126  1
2001 Ghose R, Shekhtman A, Goger MJ, Ji H, Cowburn D. A novel, specific interaction involving the Csk SH3 domain and its natural ligand. Nature Structural Biology. 8: 998-1004. PMID 11685249 DOI: 10.1038/nsb1101-998  1
2001 Ghose R, Fushman D, Cowburn D. Determination of the rotational diffusion tensor of macromolecules in solution from nmr relaxation data with a combination of exact and approximate methods--application to the determination of interdomain orientation in multidomain proteins. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 149: 204-17. PMID 11318619 DOI: 10.1006/jmre.2001.2295  1
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