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Sumith A. Kularatne - Publications

Affiliations: 
On Target Laboratory 
Area:
Oncology, Drug design and development, Targeted-drugs for cancer and inflammatory diseases, immunotherapy, Image-guided surgery,
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Sengupta S, Pandit A, Krishnan MA, Sharma R, Kularatne SA, Chelvam V. Design, synthesis, and biological evaluation of novel thiourea derivatives as small molecule inhibitors for prostate specific membrane antigen. Bioorganic Chemistry. 155: 108130. PMID 39787914 DOI: 10.1016/j.bioorg.2025.108130  0.369
2023 Stibbe JA, de Barros HA, Linders DGJ, Bhairosingh SS, Bekers EM, van Leeuwen PJ, Low PS, Kularatne SA, Vahrmeijer AL, Burggraaf J, van der Poel HG. First-in-patient study of OTL78 for intraoperative fluorescence imaging of prostate-specific membrane antigen-positive prostate cancer: a single-arm, phase 2a, feasibility trial. The Lancet. Oncology. 24: 457-467. PMID 37062295 DOI: 10.1016/S1470-2045(23)00102-X  0.637
2022 Kennedy GT, Azari FS, Bernstein E, Nadeem B, Chang A, Segil A, Carlin S, Sullivan NT, Encarnado E, Desphande C, Kularatne S, Gagare P, Thomas M, Kucharczuk JC, Christien G, et al. Targeted detection of cancer at the cellular level during biopsy by near-infrared confocal laser endomicroscopy. Nature Communications. 13: 2711. PMID 35581212 DOI: 10.1038/s41467-022-30265-z  0.807
2020 Cresswell GM, Wang B, Kischuk EM, Broman MM, Alfar RA, Vickman RE, Dimitrov DS, Kularatne SA, Sundaram CP, Singhal S, Eruslanov EB, Crist SA, Elzey BD, Ratliff TL, Low PS. Folate Receptor Beta Designates Immunosuppressive Tumor-Associated Myeloid Cells that Can Be Reprogrammed with Folate-Targeted Drugs. Cancer Research. PMID 33203700 DOI: 10.1158/0008-5472.CAN-20-1414  0.75
2018 Mahalingam SM, Kularatne SA, Myers CH, Gagare P, Norshi M, Liu X, Singhal S, Low PS. Evaluation of Novel Tumor-Targeted Near-Infrared Probe for Fluorescence-Guided Surgery of Cancer. Journal of Medicinal Chemistry. PMID 30296376 DOI: 10.1021/Acs.Jmedchem.8B01115  0.717
2018 Kularatne SA, Thomas M, Myers CH, Gagare P, Kanduluru AK, Crain CJ, Cichocki BN. Evaluation of Novel Prostate-Specific Membrane Antigen-Targeted Near-Infrared Imaging Agent for Fluorescence-Guided Surgery for Prostate Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30201762 DOI: 10.1158/1078-0432.Ccr-18-0803  0.75
2018 Marks IS, Gardeen SS, Kurdziel SJ, Nicolaou ST, Woods JE, Kularatne SA, Low PS. Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers. Molecular Pharmaceutics. PMID 29715036 DOI: 10.1021/Acs.Molpharmaceut.8B00139  0.814
2018 Predina JD, Newton AD, Xia L, Corbett C, Connolly C, Shin M, Sulyok LF, Litzky L, Deshpande C, Nie S, Kularatne SA, Low PS, Singhal S. An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas. Oncotarget. 9: 13517-13529. PMID 29568374 DOI: 10.18632/Oncotarget.24399  0.712
2017 Predina JD, Newton AD, Connolly C, Dunbar A, Baldassari M, Deshpande C, Cantu E, Stadanlick J, Kularatne SA, Low PS, Singhal S. Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29241970 DOI: 10.1016/J.Ymthe.2017.10.016  0.723
2017 Predina JD, Newton AD, Keating J, Barbosa EM, Okusanya O, Xia L, Dunbar A, Connolly C, Baldassari MP, Mizelle J, Delikatny EJ, Kucharczuk JC, Deshpande C, Kularatne SA, Low P, et al. Intraoperative Molecular Imaging Combined With Positron Emission Tomography Improves Surgical Management of Peripheral Malignant Pulmonary Nodules. Annals of Surgery. PMID 28746152 DOI: 10.1097/Sla.0000000000002382  0.513
2015 De Jesus E, Keating JJ, Kularatne SA, Jiang J, Judy R, Predina J, Nie S, Low P, Singhal S. Comparison of Folate Receptor Targeted Optical Contrast Agents for Intraoperative Molecular Imaging. International Journal of Molecular Imaging. 2015: 469047. PMID 26491562 DOI: 10.1155/2015/469047  0.749
2014 Kularatne SA, Deshmukh V, Ma J, Tardif V, Lim RK, Pugh HM, Sun Y, Manibusan A, Sellers AJ, Barnett RS, Srinagesh S, Forsyth JS, Hassenpflug W, Tian F, Javahishvili T, et al. A CXCR4-targeted site-specific antibody-drug conjugate. Angewandte Chemie (International Ed. in English). 53: 11863-7. PMID 25213874 DOI: 10.1002/Anie.201408103  0.821
2013 Kularatne SA, Deshmukh V, Gymnopoulos M, Biroc SL, Xia J, Srinagesh S, Sun Y, Zou N, Shimazu M, Pinkstaff J, Ensari S, Knudsen N, Manibusan A, Axup JY, Kim CH, et al. Recruiting cytotoxic T cells to folate-receptor-positive cancer cells. Angewandte Chemie (International Ed. in English). 52: 12101-4. PMID 24573789 DOI: 10.1002/Anie.201306866  0.794
2013 Henne WA, Kularatne SA, Hakenjos J, Carron JD, Henne KL. Synthesis and activity of a folate targeted monodisperse PEG camptothecin conjugate. Bioorganic & Medicinal Chemistry Letters. 23: 5810-3. PMID 24064501 DOI: 10.1016/J.Bmcl.2013.08.113  0.417
2013 Kularatne SA, Bélanger MJ, Meng X, Connolly BM, Vanko A, Suresch DL, Guenther I, Wang S, Low PS, McQuade P, Trotter DG. Comparative analysis of folate derived PET imaging agents with [(18)F]-2-fluoro-2-deoxy-d-glucose using a rodent inflammatory paw model. Molecular Pharmaceutics. 10: 3103-11. PMID 23819524 DOI: 10.1021/Mp4001684  0.616
2013 Kelderhouse LE, Chelvam V, Wayua C, Mahalingam S, Poh S, Kularatne SA, Low PS. Development of tumor-targeted near infrared probes for fluorescence guided surgery. Bioconjugate Chemistry. 24: 1075-80. PMID 23642154 DOI: 10.1021/Bc400131A  0.865
2013 Gent YY, Weijers K, Molthoff CF, Windhorst AD, Huisman MC, Smith DE, Kularatne SA, Jansen G, Low PS, Lammertsma AA, van der Laken CJ. Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis. Arthritis Research & Therapy. 15: R37. PMID 23452511 DOI: 10.1186/Ar4191  0.598
2013 Gent YY, Weijers K, Molthoff CF, Windhorst AD, Huisman MC, Smith DE, Kularatne SA, Jansen G, Low PS, Lammertsma AA, van der Laken CJ. AB0761 Synthesis and evaluation of the novel folate receptor ligand [18f]fluoro-peg-folate for macrophage targeting in a rat model of arthritis Annals of the Rheumatic Diseases. 72: A1021.3-A1021. DOI: 10.1136/Annrheumdis-2013-Eular.3083  0.596
2012 Vaitilingam B, Chelvam V, Kularatne SA, Poh S, Ayala-Lopez W, Low PS. A folate receptor-α-specific ligand that targets cancer tissue and not sites of inflammation. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 53: 1127-34. PMID 22693311 DOI: 10.2967/Jnumed.111.099390  0.784
2012 Dubrovska A, Elliott J, Salamone RJ, Telegeev GD, Stakhovsky AE, Schepotin IB, Yan F, Wang Y, Bouchez LC, Kularatne SA, Watson J, Trussell C, Reddy VA, Cho CY, Schultz PG. CXCR4 expression in prostate cancer progenitor cells. Plos One. 7: e31226. PMID 22359577 DOI: 10.1371/Journal.Pone.0031226  0.821
2012 Yang JJ, Kularatne SA, Chen X, Low PS, Wang E. Characterization of in vivo disulfide-reduction mediated drug release in mouse kidneys. Molecular Pharmaceutics. 9: 310-7. PMID 22171616 DOI: 10.1021/Mp200483T  0.619
2012 Henne WA, Kularatne SA, Ayala-López W, Doorneweerd DD, Stinnette TW, Lu Y, Low PS. Synthesis and activity of folate conjugated didemnin B for potential treatment of inflammatory diseases. Bioorganic & Medicinal Chemistry Letters. 22: 709-12. PMID 22100311 DOI: 10.1016/J.Bmcl.2011.10.042  0.685
2012 Vaitilingam B, Chelvam V, Kularatne SA, Poh S, Ayala-Lopez W, Low PS. Abstract 5745: Synthesis and characterization of a folate receptor alpha-specific ligand for distinguishing cancer tissue from sites of inflammation Cancer Research. 72: 5745-5745. DOI: 10.1158/1538-7445.Am2012-5745  0.757
2012 Kelderhouse LE, Chelvam V, Wayua C, Sakkarapalayam MM, Poh S, Kularatne SA, Low PS. Abstract 374: Development of tumor-targeted near infrared dyes for fluorescence guided surgery Cancer Research. 72: 374-374. DOI: 10.1158/1538-7445.Am2012-374  0.815
2010 Kularatne SA, Venkatesh C, Santhapuram HK, Wang K, Vaitilingam B, Henne WA, Low PS. Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs. Journal of Medicinal Chemistry. 53: 7767-77. PMID 20936874 DOI: 10.1021/Jm100729B  0.806
2010 Adak AK, Leonov AP, Ding N, Thundimadathil J, Kularatne S, Low PS, Wei A. Bishydrazide glycoconjugates for lectin recognition and capture of bacterial pathogens. Bioconjugate Chemistry. 21: 2065-75. PMID 20925370 DOI: 10.1021/Bc100288C  0.569
2010 Gaind V, Kularatne S, Low PS, Webb KJ. Deep-tissue imaging of intramolecular fluorescence resonance energy-transfer parameters. Optics Letters. 35: 1314-6. PMID 20436553 DOI: 10.1364/Ol.35.001314  0.652
2010 Kularatne SA, Low PS. Targeting of nanoparticles: folate receptor. Methods in Molecular Biology (Clifton, N.J.). 624: 249-65. PMID 20217601 DOI: 10.1007/978-1-60761-609-2_17  0.675
2010 Gaind V, Webb KJ, Kularatne SA, Low PS. In vivo Fluorescence Resonance Energy Transfer and Optical Diffusion Tomography Imaging of Targeted Drug Delivery to Tumors Ieee Transactions On Biomedical Engineering. DOI: 10.1364/Biomed.2010.Bsue4  0.683
2010 Reddy JA, Xu L, Dorton R, Bloomfield A, Nelson M, Klein P, Kularatne S, Low P, Leamon C. Abstract 3248: PSMA specific imaging of prostate cancer Cancer Research. 70: 3248-3248. DOI: 10.1158/1538-7445.Am10-3248  0.717
2009 Thomas M, Kularatne SA, Qi L, Kleindl P, Leamon CP, Hansen MJ, Low PS. Ligand-targeted delivery of small interfering RNAs to malignant cells and tissues. Annals of the New York Academy of Sciences. 1175: 32-9. PMID 19796075 DOI: 10.1111/J.1749-6632.2009.04977.X  0.84
2009 Gaind V, Webb KJ, Kularatne S, Bouman CA. Towards in vivo imaging of intramolecular fluorescence resonance energy transfer parameters. Journal of the Optical Society of America. a, Optics, Image Science, and Vision. 26: 1805-13. PMID 19649115 DOI: 10.1364/Josaa.26.001805  0.314
2009 Low PS, Kularatne SA. Folate-targeted therapeutic and imaging agents for cancer. Current Opinion in Chemical Biology. 13: 256-62. PMID 19419901 DOI: 10.1016/J.Cbpa.2009.03.022  0.726
2009 Yi YS, Ayala-López W, Kularatne SA, Low PS. Folate-targeted hapten immunotherapy of adjuvant-induced arthritis: comparison of hapten potencies. Molecular Pharmaceutics. 6: 1228-36. PMID 19374407 DOI: 10.1021/Mp900070B  0.62
2009 Kularatne SA, Wang K, Santhapuram HK, Low PS. Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand. Molecular Pharmaceutics. 6: 780-9. PMID 19361233 DOI: 10.1021/Mp900069D  0.752
2009 Kularatne SA, Zhou Z, Yang J, Post CB, Low PS. Design, synthesis, and preclinical evaluation of prostate-specific membrane antigen targeted (99m)Tc-radioimaging agents. Molecular Pharmaceutics. 6: 790-800. PMID 19361232 DOI: 10.1021/Mp9000712  0.735
2009 Gaind V, Webb KJ, Kularatne SA, Low PS. In Vivo imaging of targeted drug delivery to tumors based on fluorescence resonance energy transfer and optical diffusion tomography Optics Infobase Conference Papers. DOI: 10.1364/Fio.2009.Ftul3  0.684
2009 Hale JA, Poh S, Kularatne S, Low PS, Ritchie KP. Dynamics Of Folate/Folate Receptor Complexes In KB Cells Observed Through Single Molecule Fluorescence Imaging Biophysical Journal. 96: 282a-283a. DOI: 10.1016/J.Bpj.2008.12.1399  0.724
2008 He W, Kularatne SA, Kalli KR, Prendergast FG, Amato RJ, Klee GG, Hartmann LC, Low PS. Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligands. International Journal of Cancer. Journal International Du Cancer. 123: 1968-73. PMID 18661519 DOI: 10.1002/Ijc.23717  0.728
2006 Henne WA, Doorneweerd DD, Hilgenbrink AR, Kularatne SA, Low PS. Synthesis and activity of a folate peptide camptothecin prodrug. Bioorganic & Medicinal Chemistry Letters. 16: 5350-5. PMID 16901694 DOI: 10.1016/J.Bmcl.2006.07.076  0.624
2005 Burns DH, Calderon-Kawasaki K, Kularatne S. Buried solvent determines both anion-binding selectivity and binding stoichiometry with hydrogen-bonding receptors. The Journal of Organic Chemistry. 70: 2803-7. PMID 15787574 DOI: 10.1021/Jo047756R  0.304
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