Year |
Citation |
Score |
2024 |
Parasrampuria MA, White AA, Chilamkurthy R, Pater AA, El-Azzouzi F, Ovington KN, Jensik PJ, Gagnon KT. Sequencing-guided design of genetically encoded small RNAs targeting CAG repeats for selective inhibition of mutant . Molecular Therapy. Nucleic Acids. 35: 102206. PMID 38803421 DOI: 10.1016/j.omtn.2024.102206 |
0.464 |
|
2023 |
Sudhakar S, Barkau CL, Chilamkurthy R, Barber HM, Pater AA, Moran SD, Damha MJ, Pradeepkumar PI, Gagnon KT. Binding to the Conserved and Stably Folded Guide RNA Pseudoknot Induces Cas12a Conformational Changes During Ribonucleoprotein Assembly. The Journal of Biological Chemistry. 104700. PMID 37059184 DOI: 10.1016/j.jbc.2023.104700 |
0.372 |
|
2021 |
Ageely EA, Chilamkurthy R, Jana S, Abdullahu L, O'Reilly D, Jensik PJ, Damha MJ, Gagnon KT. Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles. Nature Communications. 12: 6591. PMID 34782635 DOI: 10.1038/s41467-021-26989-z |
0.406 |
|
2020 |
Kartje ZJ, Janis HI, Mukhopadhyay S, Gagnon KT. Revisiting T7 RNA polymerase transcription in vitro with the Broccoli RNA aptamer as a simplified real-time fluorescent reporter. The Journal of Biological Chemistry. PMID 33303627 DOI: 10.1074/jbc.RA120.014553 |
0.349 |
|
2020 |
Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Chembiochem : a European Journal of Chemical Biology. PMID 32372560 DOI: 10.1002/cbic.202000136 |
0.492 |
|
2020 |
Habibian M, Harikrishna S, Fakhoury J, Barton M, Ageely EA, Cencic R, Fakih HH, Katolik A, Takahashi M, Rossi J, Pelletier J, Gagnon KT, Pradeepkumar PI, Damha MJ. Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference. Nucleic Acids Research. PMID 32282904 DOI: 10.1093/Nar/Gkaa222 |
0.358 |
|
2019 |
Barkau CL, O'Reilly D, Rohilla KJ, Damha MJ, Gagnon KT. Rationally Designed Small Nucleic Acid-Based Inhibitors of CRISPR-Cas9. Nucleic Acid Therapeutics. PMID 30990769 DOI: 10.1089/Nat.2018.0758 |
0.302 |
|
2019 |
Gagnon KT, Corey DR. Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs. Nucleic Acid Therapeutics. PMID 30907681 DOI: 10.1089/Nat.2018.0772 |
0.562 |
|
2018 |
O'Reilly D, Kartje ZJ, Ageely EA, Malek-Adamian E, Habibian M, Schofield A, Barkau CL, Rohilla KJ, DeRossett LB, Weigle AT, Damha MJ, Gagnon KT. Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity. Nucleic Acids Research. PMID 30517736 DOI: 10.1093/Nar/Gky1214 |
0.318 |
|
2018 |
Kartje ZJ, Barkau CL, Rohilla KJ, Ageely EA, Gagnon KT. Chimeric Guides Probe and Enhance Cas9 Biochemical Activity. Biochemistry. PMID 29746102 DOI: 10.1021/acs.biochem.8b00107 |
0.348 |
|
2017 |
Rohilla KJ, Gagnon KT. RNA biology of disease-associated microsatellite repeat expansions. Acta Neuropathologica Communications. 5: 63. PMID 28851463 DOI: 10.1186/s40478-017-0468-y |
0.388 |
|
2016 |
Ageely EA, Kartje ZJ, Rohilla KJ, Barkau CL, Gagnon KT. Quadruplex-flanking stem structures modulate the stability and metal ion preferences of RNA mimics of GFP. Acs Chemical Biology. PMID 27467146 DOI: 10.1021/acschembio.6b00047 |
0.353 |
|
2016 |
Kalantari R, Hicks JA, Li L, Gagnon KT, Sridhara V, Lemoff A, Mirzaei H, Corey DR. Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells. Rna (New York, N.Y.). PMID 27198507 DOI: 10.1261/Rna.056499.116 |
0.61 |
|
2016 |
Gagnon KT. Loading of Argonaute Protein with Small Duplex RNA in Cellular Extracts. Methods in Molecular Biology (Clifton, N.J.). 1421: 53-67. PMID 26965257 DOI: 10.1007/978-1-4939-3591-8_6 |
0.358 |
|
2016 |
Dodd DW, Tomchick DR, Corey DR, Gagnon KT. Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches. Biochemistry. PMID 26878348 DOI: 10.1021/Acs.Biochem.6B00136 |
0.605 |
|
2015 |
Gagnon KT, Corey DR. Stepping toward therapeutic CRISPR. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644585 DOI: 10.1073/Pnas.1521670112 |
0.537 |
|
2015 |
Hu J, Liu J, Li L, Gagnon KT, Corey DR. Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus. Chemistry & Biology. PMID 26584779 DOI: 10.1016/J.Chembiol.2015.09.016 |
0.651 |
|
2015 |
Gagnon KT, Maxwell ES. Assessing intermolecular RNA:RNA interactions within a ribonucleoprotein complex using heavy metal cleavage mapping. Methods in Molecular Biology (Clifton, N.J.). 1240: 125-34. PMID 25352141 DOI: 10.1007/978-1-4939-1896-6_9 |
0.405 |
|
2014 |
Gagnon KT, Li L, Janowski BA, Corey DR. Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading. Nature Protocols. 9: 2045-60. PMID 25079428 DOI: 10.1038/Nprot.2014.135 |
0.593 |
|
2014 |
Gagnon KT, Li L, Chu Y, Janowski BA, Corey DR. RNAi factors are present and active in human cell nuclei. Cell Reports. 6: 211-21. PMID 24388755 DOI: 10.1016/J.Celrep.2013.12.013 |
0.625 |
|
2013 |
Matsui M, Chu Y, Zhang H, Gagnon KT, Shaikh S, Kuchimanchi S, Manoharan M, Corey DR, Janowski BA. Promoter RNA links transcriptional regulation of inflammatory pathway genes. Nucleic Acids Research. 41: 10086-109. PMID 23999091 DOI: 10.1093/Nar/Gkt777 |
0.64 |
|
2013 |
Dodd DW, Gagnon KT, Corey DR. Digital quantitation of potential therapeutic target RNAs. Nucleic Acid Therapeutics. 23: 188-94. PMID 23656494 DOI: 10.1089/Nat.2013.0427 |
0.632 |
|
2012 |
Gagnon KT, Biswas S, Zhang X, Brown BA, Wollenzien P, Mattos C, Maxwell ES. Structurally conserved Nop56/58 N-terminal domain facilitates archaeal box C/D ribonucleoprotein-guided methyltransferase activity. The Journal of Biological Chemistry. 287: 19418-28. PMID 22496443 DOI: 10.1074/Jbc.M111.323253 |
0.338 |
|
2012 |
Gagnon KT, Corey DR. Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression. Nucleic Acid Therapeutics. 22: 3-16. PMID 22283730 DOI: 10.1089/Nat.2011.0330 |
0.671 |
|
2011 |
Gagnon KT, Watts JK, Pendergraff HM, Montaillier C, Thai D, Potier P, Corey DR. Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates. Journal of the American Chemical Society. 133: 8404-7. PMID 21539318 DOI: 10.1021/Ja200312Y |
0.659 |
|
2011 |
Biswas S, Buhrman G, Gagnon K, Mattos C, Brown BA, Maxwell ES. Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. Biochemistry. 50: 2907-18. PMID 21366326 DOI: 10.1021/Bi1020474 |
0.366 |
|
2011 |
Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biological Chemistry. 392: 315-25. PMID 21294677 DOI: 10.1515/Bc.2011.045 |
0.681 |
|
2011 |
Gagnon KT, Maxwell ES. Electrophoretic mobility shift assay for characterizing RNA-protein interaction. Methods in Molecular Biology (Clifton, N.J.). 703: 275-91. PMID 21125497 DOI: 10.1007/978-1-59745-248-9_19 |
0.379 |
|
2010 |
Gagnon KT, Pendergraff HM, Deleavey GF, Swayze EE, Potier P, Randolph J, Roesch EB, Chattopadhyaya J, Damha MJ, Bennett CF, Montaillier C, Lemaitre M, Corey DR. Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry. 49: 10166-78. PMID 21028906 DOI: 10.1021/Bi101208K |
0.585 |
|
2010 |
Yue X, Schwartz JC, Chu Y, Younger ST, Gagnon KT, Elbashir S, Janowski BA, Corey DR. Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini. Nature Chemical Biology. 6: 621-9. PMID 20581822 DOI: 10.1038/Nchembio.400 |
0.703 |
|
2010 |
Gagnon KT, Zhang X, Qu G, Biswas S, Suryadi J, Brown BA, Maxwell ES. Signature amino acids enable the archaeal L7Ae box C/D RNP core protein to recognize and bind the K-loop RNA motif. Rna (New York, N.Y.). 16: 79-90. PMID 19926724 DOI: 10.1261/rna.1692310 |
0.334 |
|
2009 |
Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR. Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nature Biotechnology. 27: 478-84. PMID 19412185 DOI: 10.1038/Nbt.1539 |
0.713 |
|
2009 |
Gagnon KT, Ju SY, Goshe MB, Maxwell ES, Franzen S. A role for hydrophobicity in a Diels-Alder reaction catalyzed by pyridyl-modified RNA. Nucleic Acids Research. 37: 3074-82. PMID 19304744 DOI: 10.1093/Nar/Gkp177 |
0.368 |
|
2007 |
Gagnon K, Zhang X, Maxwell ES. In vitro reconstitution and affinity purification of catalytically active archaeal box C/D sRNP complexes. Methods in Enzymology. 425: 263-82. PMID 17673088 DOI: 10.1016/S0076-6879(07)25012-8 |
0.378 |
|
2006 |
Gagnon KT, Zhang X, Agris PF, Maxwell ES. Assembly of the archaeal box C/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling. Journal of Molecular Biology. 362: 1025-42. PMID 16949610 DOI: 10.1016/J.Jmb.2006.07.091 |
0.329 |
|
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