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Keith Gagnon - Publications

Affiliations: 
2010-2015 Chemistry Univ. Southern Illinois 
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Parasrampuria MA, White AA, Chilamkurthy R, Pater AA, El-Azzouzi F, Ovington KN, Jensik PJ, Gagnon KT. Sequencing-guided design of genetically encoded small RNAs targeting CAG repeats for selective inhibition of mutant . Molecular Therapy. Nucleic Acids. 35: 102206. PMID 38803421 DOI: 10.1016/j.omtn.2024.102206  0.464
2023 Sudhakar S, Barkau CL, Chilamkurthy R, Barber HM, Pater AA, Moran SD, Damha MJ, Pradeepkumar PI, Gagnon KT. Binding to the Conserved and Stably Folded Guide RNA Pseudoknot Induces Cas12a Conformational Changes During Ribonucleoprotein Assembly. The Journal of Biological Chemistry. 104700. PMID 37059184 DOI: 10.1016/j.jbc.2023.104700  0.372
2021 Ageely EA, Chilamkurthy R, Jana S, Abdullahu L, O'Reilly D, Jensik PJ, Damha MJ, Gagnon KT. Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles. Nature Communications. 12: 6591. PMID 34782635 DOI: 10.1038/s41467-021-26989-z  0.406
2020 Kartje ZJ, Janis HI, Mukhopadhyay S, Gagnon KT. Revisiting T7 RNA polymerase transcription in vitro with the Broccoli RNA aptamer as a simplified real-time fluorescent reporter. The Journal of Biological Chemistry. PMID 33303627 DOI: 10.1074/jbc.RA120.014553  0.349
2020 Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Chembiochem : a European Journal of Chemical Biology. PMID 32372560 DOI: 10.1002/cbic.202000136  0.492
2020 Habibian M, Harikrishna S, Fakhoury J, Barton M, Ageely EA, Cencic R, Fakih HH, Katolik A, Takahashi M, Rossi J, Pelletier J, Gagnon KT, Pradeepkumar PI, Damha MJ. Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference. Nucleic Acids Research. PMID 32282904 DOI: 10.1093/Nar/Gkaa222  0.358
2019 Barkau CL, O'Reilly D, Rohilla KJ, Damha MJ, Gagnon KT. Rationally Designed Small Nucleic Acid-Based Inhibitors of CRISPR-Cas9. Nucleic Acid Therapeutics. PMID 30990769 DOI: 10.1089/Nat.2018.0758  0.302
2019 Gagnon KT, Corey DR. Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs. Nucleic Acid Therapeutics. PMID 30907681 DOI: 10.1089/Nat.2018.0772  0.562
2018 O'Reilly D, Kartje ZJ, Ageely EA, Malek-Adamian E, Habibian M, Schofield A, Barkau CL, Rohilla KJ, DeRossett LB, Weigle AT, Damha MJ, Gagnon KT. Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity. Nucleic Acids Research. PMID 30517736 DOI: 10.1093/Nar/Gky1214  0.318
2018 Kartje ZJ, Barkau CL, Rohilla KJ, Ageely EA, Gagnon KT. Chimeric Guides Probe and Enhance Cas9 Biochemical Activity. Biochemistry. PMID 29746102 DOI: 10.1021/acs.biochem.8b00107  0.348
2017 Rohilla KJ, Gagnon KT. RNA biology of disease-associated microsatellite repeat expansions. Acta Neuropathologica Communications. 5: 63. PMID 28851463 DOI: 10.1186/s40478-017-0468-y  0.388
2016 Ageely EA, Kartje ZJ, Rohilla KJ, Barkau CL, Gagnon KT. Quadruplex-flanking stem structures modulate the stability and metal ion preferences of RNA mimics of GFP. Acs Chemical Biology. PMID 27467146 DOI: 10.1021/acschembio.6b00047  0.353
2016 Kalantari R, Hicks JA, Li L, Gagnon KT, Sridhara V, Lemoff A, Mirzaei H, Corey DR. Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells. Rna (New York, N.Y.). PMID 27198507 DOI: 10.1261/Rna.056499.116  0.61
2016 Gagnon KT. Loading of Argonaute Protein with Small Duplex RNA in Cellular Extracts. Methods in Molecular Biology (Clifton, N.J.). 1421: 53-67. PMID 26965257 DOI: 10.1007/978-1-4939-3591-8_6  0.358
2016 Dodd DW, Tomchick DR, Corey DR, Gagnon KT. Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches. Biochemistry. PMID 26878348 DOI: 10.1021/Acs.Biochem.6B00136  0.605
2015 Gagnon KT, Corey DR. Stepping toward therapeutic CRISPR. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644585 DOI: 10.1073/Pnas.1521670112  0.537
2015 Hu J, Liu J, Li L, Gagnon KT, Corey DR. Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus. Chemistry & Biology. PMID 26584779 DOI: 10.1016/J.Chembiol.2015.09.016  0.651
2015 Gagnon KT, Maxwell ES. Assessing intermolecular RNA:RNA interactions within a ribonucleoprotein complex using heavy metal cleavage mapping. Methods in Molecular Biology (Clifton, N.J.). 1240: 125-34. PMID 25352141 DOI: 10.1007/978-1-4939-1896-6_9  0.405
2014 Gagnon KT, Li L, Janowski BA, Corey DR. Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading. Nature Protocols. 9: 2045-60. PMID 25079428 DOI: 10.1038/Nprot.2014.135  0.593
2014 Gagnon KT, Li L, Chu Y, Janowski BA, Corey DR. RNAi factors are present and active in human cell nuclei. Cell Reports. 6: 211-21. PMID 24388755 DOI: 10.1016/J.Celrep.2013.12.013  0.625
2013 Matsui M, Chu Y, Zhang H, Gagnon KT, Shaikh S, Kuchimanchi S, Manoharan M, Corey DR, Janowski BA. Promoter RNA links transcriptional regulation of inflammatory pathway genes. Nucleic Acids Research. 41: 10086-109. PMID 23999091 DOI: 10.1093/Nar/Gkt777  0.64
2013 Dodd DW, Gagnon KT, Corey DR. Digital quantitation of potential therapeutic target RNAs. Nucleic Acid Therapeutics. 23: 188-94. PMID 23656494 DOI: 10.1089/Nat.2013.0427  0.632
2012 Gagnon KT, Biswas S, Zhang X, Brown BA, Wollenzien P, Mattos C, Maxwell ES. Structurally conserved Nop56/58 N-terminal domain facilitates archaeal box C/D ribonucleoprotein-guided methyltransferase activity. The Journal of Biological Chemistry. 287: 19418-28. PMID 22496443 DOI: 10.1074/Jbc.M111.323253  0.338
2012 Gagnon KT, Corey DR. Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression. Nucleic Acid Therapeutics. 22: 3-16. PMID 22283730 DOI: 10.1089/Nat.2011.0330  0.671
2011 Gagnon KT, Watts JK, Pendergraff HM, Montaillier C, Thai D, Potier P, Corey DR. Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates. Journal of the American Chemical Society. 133: 8404-7. PMID 21539318 DOI: 10.1021/Ja200312Y  0.659
2011 Biswas S, Buhrman G, Gagnon K, Mattos C, Brown BA, Maxwell ES. Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. Biochemistry. 50: 2907-18. PMID 21366326 DOI: 10.1021/Bi1020474  0.366
2011 Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biological Chemistry. 392: 315-25. PMID 21294677 DOI: 10.1515/Bc.2011.045  0.681
2011 Gagnon KT, Maxwell ES. Electrophoretic mobility shift assay for characterizing RNA-protein interaction. Methods in Molecular Biology (Clifton, N.J.). 703: 275-91. PMID 21125497 DOI: 10.1007/978-1-59745-248-9_19  0.379
2010 Gagnon KT, Pendergraff HM, Deleavey GF, Swayze EE, Potier P, Randolph J, Roesch EB, Chattopadhyaya J, Damha MJ, Bennett CF, Montaillier C, Lemaitre M, Corey DR. Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry. 49: 10166-78. PMID 21028906 DOI: 10.1021/Bi101208K  0.585
2010 Yue X, Schwartz JC, Chu Y, Younger ST, Gagnon KT, Elbashir S, Janowski BA, Corey DR. Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini. Nature Chemical Biology. 6: 621-9. PMID 20581822 DOI: 10.1038/Nchembio.400  0.703
2010 Gagnon KT, Zhang X, Qu G, Biswas S, Suryadi J, Brown BA, Maxwell ES. Signature amino acids enable the archaeal L7Ae box C/D RNP core protein to recognize and bind the K-loop RNA motif. Rna (New York, N.Y.). 16: 79-90. PMID 19926724 DOI: 10.1261/rna.1692310  0.334
2009 Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR. Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nature Biotechnology. 27: 478-84. PMID 19412185 DOI: 10.1038/Nbt.1539  0.713
2009 Gagnon KT, Ju SY, Goshe MB, Maxwell ES, Franzen S. A role for hydrophobicity in a Diels-Alder reaction catalyzed by pyridyl-modified RNA. Nucleic Acids Research. 37: 3074-82. PMID 19304744 DOI: 10.1093/Nar/Gkp177  0.368
2007 Gagnon K, Zhang X, Maxwell ES. In vitro reconstitution and affinity purification of catalytically active archaeal box C/D sRNP complexes. Methods in Enzymology. 425: 263-82. PMID 17673088 DOI: 10.1016/S0076-6879(07)25012-8  0.378
2006 Gagnon KT, Zhang X, Agris PF, Maxwell ES. Assembly of the archaeal box C/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling. Journal of Molecular Biology. 362: 1025-42. PMID 16949610 DOI: 10.1016/J.Jmb.2006.07.091  0.329
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