Jonathan Watts - Publications

Affiliations: 
2009-2013 Biochemistry U. Mass. Medical School 

14/109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-quadruplexes. Chembiochem : a European Journal of Chemical Biology. PMID 32372560 DOI: 10.1002/cbic.202000136  0.52
2018 Li L, Shen X, Liu Z, Norrbom M, Prakash TP, O'Reilly D, Sharma VK, Damha MJ, Watts JK, Rigo F, Corey DR. Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat. Nucleic Acid Therapeutics. PMID 29341839 DOI: 10.1089/nat.2017.0703  0.52
2018 Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV. Oligonucleotides Targeting TCF4 Triplet Repeat Expansion Inhibit RNA Foci and Mis-splicing in Fuchs' Dystrophy. Human Molecular Genetics. PMID 29325021 DOI: 10.1093/hmg/ddy018  0.52
2017 Pendergraff HM, Krishnamurthy PM, Debacker AJ, Moazami MP, Sharma VK, Niitsoo L, Yu Y, Tan YN, Haitchi HM, Watts JK. Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA. Molecular Therapy. Nucleic Acids. 8: 158-168. PMID 28918018 DOI: 10.1016/j.omtn.2017.06.012  0.48
2016 Pendergraff HM, Debacker AJ, Watts JK. Single-Stranded Silencing RNAs: Hit Rate and Chemical Modification. Nucleic Acid Therapeutics. PMID 27123752 DOI: 10.1089/nat.2015.0557  0.48
2015 Poma A, Brahmbhatt H, Pendergraff HM, Watts JK, Turner NW. Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles. Advanced Materials (Deerfield Beach, Fla.). 27: 750-8. PMID 25413444 DOI: 10.1002/adma.201404235  0.52
2014 Schaukowitch K, Joo JY, Liu X, Watts JK, Martinez C, Kim TK. Enhancer RNA facilitates NELF release from immediate early genes. Molecular Cell. 56: 29-42. PMID 25263592 DOI: 10.1016/j.molcel.2014.08.023  0.52
2012 Watts JK, Corey DR. Silencing disease genes in the laboratory and the clinic. The Journal of Pathology. 226: 365-79. PMID 22069063 DOI: 10.1002/path.2993  0.52
2011 Gagnon KT, Watts JK, Pendergraff HM, Montaillier C, Thai D, Potier P, Corey DR. Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates. Journal of the American Chemical Society. 133: 8404-7. PMID 21539318 DOI: 10.1021/ja200312y  0.52
2011 Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biological Chemistry. 392: 315-25. PMID 21294677 DOI: 10.1515/BC.2011.045  0.52
2011 Anzahaee MY, Watts JK, Alla NR, Nicholson AW, Damha MJ. Energetically important C-H···F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity. Journal of the American Chemical Society. 133: 728-31. PMID 21171597 DOI: 10.1021/ja109817p  0.52
2010 Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ. Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic Acids Research. 38: 4547-57. PMID 20413581 DOI: 10.1093/nar/gkq181  0.52
2010 Watts JK, Yu D, Charisse K, Montaillier C, Potier P, Manoharan M, Corey DR. Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters. Nucleic Acids Research. 38: 5242-59. PMID 20403811 DOI: 10.1093/nar/gkq258  0.52
2010 Watts JK, Corey DR. Clinical status of duplex RNA. Bioorganic & Medicinal Chemistry Letters. 20: 3203-7. PMID 20399650 DOI: 10.1016/j.bmcl.2010.03.109  0.52
Low-probability matches
2017 Sharma VK, Singh SK, Krishnamurthy PM, Alterman JF, Haraszti RA, Khvorova A, Prasad AK, Watts JK. Synthesis and biological properties of triazole-linked locked nucleic acid. Chemical Communications (Cambridge, England). PMID 28736781 DOI: 10.1039/c7cc04092j  0.12
2010 Watts JK, Martín-Pintado N, Gómez-Pinto I, Schwartzentruber J, Portella G, Orozco M, González C, Damha MJ. Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility. Nucleic Acids Research. 38: 2498-511. PMID 20071751 DOI: 10.1093/nar/gkp1225  0.08
2009 Deleavey GF, Watts JK, Damha MJ. Chemical modification of siRNA. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 16.3. PMID 20013783 DOI: 10.1002/0471142700.nc1603s39  0.08
2009 Watts JK, Katolik A, Viladoms J, Damha MJ. Studies on the hydrolytic stability of 2'-fluoroarabinonucleic acid (2'F-ANA). Organic & Biomolecular Chemistry. 7: 1904-10. PMID 19590787 DOI: 10.1039/b900443b  0.08
2008 Watts JK, Deleavey GF, Damha MJ. Chemically modified siRNA: tools and applications. Drug Discovery Today. 13: 842-55. PMID 18614389 DOI: 10.1016/j.drudis.2008.05.007  0.08
2008 Watts JK, Johnston BD, Jayakanthan K, Wahba AS, Pinto BM, Damha MJ. Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide. Journal of the American Chemical Society. 130: 8578-9. PMID 18543920 DOI: 10.1021/ja802205u  0.08
2007 Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Mario Pinto B, Damha MJ. 2'-Fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Research. 35: 1441-1451. PMID 28383739 DOI: 10.1093/nar/gkl1153  0.08
2007 Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Pinto BM, Damha MJ. 2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Research. 35: 1441-51. PMID 17284457 DOI: 10.1093/nar/gkl1153  0.08
2006 Watts JK, Sadalapure K, Choubdar N, Pinto BM, Damha MJ. Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU). The Journal of Organic Chemistry. 71: 921-5. PMID 16438502 DOI: 10.1021/jo051844+  0.08
2019 Watts JK, Brown RH, Khvorova A. Nucleic Acid Therapeutics for Neurological Diseases. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31037650 DOI: 10.1007/s13311-019-00736-1  0.04
2018 Debacker AJ, Sharma VK, Meda Krishnamurthy P, O'Reilly D, Greenhill R, Watts J. Next-generation PNA chimeras exhibit high affinity and potent gene silencing. Biochemistry. PMID 30520300 DOI: 10.1021/acs.biochem.8b00827  0.04
2018 Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nature Communications. 9: 2641. PMID 29980686 DOI: 10.1038/s41467-018-05073-z  0.04
2017 Khvorova A, Watts JK. The chemical evolution of oligonucleotide therapies of clinical utility. Nature Biotechnology. PMID 28244990 DOI: 10.1038/nbt.3765  0.04
2020 Oomen ME, Hedger AK, Watts JK, Dekker J. Detecting chromatin interactions between and along sister chromatids with SisterC. Nature Methods. 17: 1002-1009. PMID 32968250 DOI: 10.1038/s41592-020-0930-9  0.01
2020 Wang F, Zuroske T, Watts JK. RNA therapeutics on the rise. Nature Reviews. Drug Discovery. PMID 32341501 DOI: 10.1038/d41573-020-00078-0  0.01
2020 Watts JK, Ockene IS. RNA Interference for the Masses? siRNA Targeting PCSK9 Promises Prevention of Cardiovascular Disease. Nucleic Acid Therapeutics. PMID 31928497 DOI: 10.1089/nat.2019.0835  0.01
2019 Aartsma-Rus A, Watts JK. The Munich Meeting: Medical Maturation, More Mechanisms, and Milasen. Nucleic Acid Therapeutics. 29: 302-304. PMID 31804155 DOI: 10.1089/nat.2019.29003.aar  0.01
2018 Sharma VK, Osborn MF, Hassler M, Echeverria D, Ly S, Ulashchik E, Martynenko-Makaev Y, Shmanai VV, Zatsepin TS, Khvorova A, Watts J. Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo. Bioconjugate Chemistry. PMID 29898368 DOI: 10.1021/acs.bioconjchem.8b00365  0.01
2018 Muellner P, Watts J, Bingham P, Bullians M, Gould B, Pande A, Riding T, Stevens P, Vink D, Stärk KD. SurF: an innovative framework in biosecurity and animal health surveillance evaluation. Transboundary and Emerging Diseases. PMID 29770591 DOI: 10.1111/tbed.12898  0.01
2018 Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A. Efficient gene silencing in brain tumors with hydrophobically modified siRNAs. Molecular Cancer Therapeutics. PMID 29654062 DOI: 10.1158/1535-7163.MCT-17-1144  0.01
2016 Watts J. Brazil's health system woes worsen in economic crisis. Lancet (London, England). 387: 1603-4. PMID 27116057 DOI: 10.1016/S0140-6736(16)30249-5  0.01
2015 Sharma VK, Watts JK. Oligonucleotide therapeutics: chemistry, delivery and clinical progress. Future Medicinal Chemistry. 7: 2221-42. PMID 26510815 DOI: 10.4155/fmc.15.144  0.01
2015 Mu F, Lucas JT, Watts JM, Johnson AJ, Daniel Bourland J, Laxton AW, Chan MD, Tatter SB. Tumor resection with carmustine wafer placement as salvage therapy after local failure of radiosurgery for brain metastasis. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 22: 561-5. PMID 25560387 DOI: 10.1016/j.jocn.2014.08.020  0.01
2014 Watts J. Haiti making good progress in health but challenges remain The Lancet. 384: 1413-1414. PMID 25390310 DOI: 10.1016/S0140-6736(14)61835-3  0.01
2013 Watts JK. Locked nucleic acid: tighter is different. Chemical Communications (Cambridge, England). 49: 5618-20. PMID 23682352 DOI: 10.1039/c3cc40340h  0.01
2013 Watts JM, Whitlow CT, Maldjian JA. Clinical applications of arterial spin labeling. Nmr in Biomedicine. 26: 892-900. PMID 23378178 DOI: 10.1002/nbm.2904  0.01
2009 Watts J. Lead poisoning cases spark riots in China. Lancet (London, England). 374: 868. PMID 19757511  0.01
2008 Watts J. China's environmental health challenges. Lancet (London, England). 372: 1451-2. PMID 18975391  0.01
2008 Watts J. Chen Zhu: from barefoot doctor to China's Minister of Health. Lancet (London, England). 372: 1455. PMID 18930519 DOI: 10.1016/S0140-6736(08)61561-5  0.01
2008 Watts J. China's health challenges after the earthquake. Lancet (London, England). 371: 1825-6. PMID 18536073  0.01
2008 Watts J. China's health reforms tilt away from the market Lancet. 371: 292. PMID 18300378  0.01
2008 Watts J. Sex, drugs, and HIV/AIDS in China Lancet. 371: 103-104. PMID 18196617 DOI: 10.1016/S0140-6736(08)60087-2  0.01
2007 Watts J. North Korea shows signs of openness after flood Lancet. 370: 1021-1022. PMID 17893954 DOI: 10.1016/S0140-6736(07)61459-7  0.01
2007 Watts J. China introduces new rules to deter human organ trade Lancet. 369: 1917-1918. PMID 17566160 DOI: 10.1016/S0140-6736(07)60897-6  0.01
2007 Watts J. Protests in China over suspicions of a pay-or-die policy Lancet. 369: 93-94. PMID 17228420 DOI: 10.1016/S0140-6736(07)60050-6  0.01
2006 Watts J. Doctors blame air pollution for China's asthma increases Lancet. 368: 719-720. PMID 16938905 DOI: 10.1016/S0140-6736(06)69267-2  0.01
2006 Watts J. China's rural health reforms tackle entrenched inequalities. Lancet (London, England). 367: 1564-5. PMID 16703674 DOI: 10.1016/S0140-6736(06)68675-3  0.01
2006 Watts J. AIDS in China: new legislation, old doubts. Lancet (London, England). 367: 803-4. PMID 16535770 DOI: 10.1016/S0140-6736(06)68318-9  0.01
2005 Watts J. Feature: Olympian pins and needles. Lancet (London, England). 366: S62-3. PMID 16360761 DOI: 10.1016/S0140-6736(05)67857-9  0.01
2005 Watts J. Last orders in Pyongyang Lancet. 366: 1345-1347. PMID 16231412 DOI: 10.1016/S0140-6736(05)67548-4  0.01
2005 Watts J. Chinese officials accused of forcing abortions in Shandong. Lancet (London, England). 366: 1253. PMID 16220581 DOI: 10.1016/S0140-6736(05)67510-1  0.01
2005 Watts J. Vietnam needs cash to stave off future outbreaks of bird flu. Lancet (London, England). 365: 1759-60. PMID 15915564 DOI: 10.1016/S0140-6736(05)66565-8  0.01
2005 Watts J. Thailand shows the world it can cope alone. Lancet (London, England). 365: 284. PMID 15672483 DOI: 10.1016/S0140-6736(05)17807-6  0.01
2005 Watts J. Controversy in China. Lancet (London, England). 365: 109-10. PMID 15643702 DOI: 10.1016/S0140-6736(05)17721-6  0.01
2004 Watts J. Wheeling and healing. Lancet (London, England). 364: 1205-6. PMID 15470806 DOI: 10.1016/S0140-6736(04)17161-4  0.01
2004 Watts J. Profile: Masood Hyder, UN humanitarian coordinator in North Korea Lancet. 364: 1031. PMID 15455485  0.01
2004 Watts J. Wan Yanhai, Director of the Aizhixing Institute of Health Education. Lancet (London, England). 364: 21. PMID 15237533  0.01
2004 Watts J. Chinese province leads the way in facing up to HIV/AIDS. Yunnan Province's radical approach marks a new openness to HIV/AIDS in China Lancet. 363: 1964. PMID 15195670  0.01
2004 Watts J. SARS under control, but lab-safety questions remain Lancet. 363: 1780. PMID 15174476  0.01
2004 Watts J. Manufacturers face jail after baby milk kills 50 in China Lancet. 363: 1448. PMID 15132150  0.01
2004 Watts J. Shanghai to allow divorcees a second child Lancet. 363: 1374. PMID 15114992  0.01
2004 Watts J. China's shift in HIV/AIDS policy marks turnaround on health. Pledge to provide free HIV tests shows China is starting to take action on combating the disease. Lancet (London, England). 363: 1370-1. PMID 15112701  0.01
2004 Watts J. China and USA row over human rights. USA again files resolution at UN conference condemning China's human rights record. Lancet (London, England). 363: 1287. PMID 15101375  0.01
2004 Watts J. China sex education lags behind sexual activity. Phasing out of pre-marriage health checks leaves authorities with no sexual-education tools Lancet. 363: 1208. PMID 15083825  0.01
2004 Watts J. Asian nations step up action to curb spread of avian influenza. Outbreak is spreading at an unprecendented speed, WHO says, and nowhere can be considered safe. Lancet (London, England). 363: 373. PMID 15074299  0.01
2004 Watts J. China's cosmetic surgery craze. Leg-lengthening operations to fight height predjudice can leave patients crippled Lancet. 363: 958. PMID 15046120  0.01
2004 Watts J. China culls wild animals to prevent new SARS threat. Lancet (London, England). 363: 134. PMID 14733188 DOI: 10.1016/S0140-6736(03)15313-5  0.01
2004 Watts J. China promises to dash hopes of tobacco industry giants. By signing up to WHO's tobacco treaty, China pledges to tighten controls on cigarette industry. Lancet (London, England). 363: 50. PMID 14727619  0.01
2003 Watts J. Health-care divide widens in North Korea: Rising prices and falling wages have left many urban workers reliant on international aid Lancet. 362: 2072-2073. PMID 14700065 DOI: 10.1016/S0140-6736(03)15151-3  0.01
2003 Watts J. China faces up to HIV/AIDS epidemic. World AIDS day is marked by launch of huge public-awareness campaign. Lancet (London, England). 362: 1983. PMID 14686357  0.01
2003 Watts J. UN highlights North Korea in appeal for aid Lancet. 362: 1814. PMID 14661622  0.01
2003 Watts J. HIV could blunt progress in China, Clinton warns Lancet. 362: 1636. PMID 14631966  0.01
2003 Watts J. China makes preparations for possible new SARS outbreak. Measures include improved training, more hospital beds, and a better national reporting system Lancet. 362: 1294. PMID 14577442  0.01
2003 Watts J. Report details lessons from SARS outbreak Lancet. 362: 1207. PMID 14570038  0.01
2003 Watts J. More cash for health care in China Lancet. 362: 1050. PMID 14526780  0.01
2003 Watts J. Human rights organisation blasts China over HIV/AIDS cover-up. Human Rights Watch accuses Chinese government of being "in denial" over scale of HIV/AIDS epidemic Lancet. 362: 879. PMID 13679001  0.01
2003 Watts J. Tibetan health care takes back seat to infrastructure. Government emphasises railway and other engineering works rather than public health. Lancet (London, England). 362: 810. PMID 13678901  0.01
2003 Watts J. Government forced to put doctors under the spotlight. Calls for transparency prompt Japanese doctors to reexamine the way they practise medicine Lancet. 361: 2058. PMID 12814729  0.01
2003 Watts J. China takes drastic action over SARS threat: But has it done enough to avert a disaster, or is the SARS crisis set to deepen? Lancet. 361: 1708-1709. PMID 12767741 DOI: 10.1016/S0140-6736(03)13383-1  0.01
2003 Watts J. Panel advises against egg and sperm donations from siblings Lancet. 361: 1532. PMID 12737877  0.01
2003 Watts J. Water water everywhere, but not a drop to report. Lancet (London, England). 361: 1274-5. PMID 12699960 DOI: 10.1016/S0140-6736(03)13035-8  0.01
2003 Watts J. Forum debates private sector role in global water supply: Despite many arguments, the World Water Forum agrees on need for better worldwide sanitation Lancet. 361: 1022-1023. PMID 12660069 DOI: 10.1016/S0140-6736(03)12849-8  0.01
2003 Watts J. North Korea's stance unravels years of work by relief agencies. Lancet (London, England). 361: 760-1. PMID 12620749 DOI: 10.1016/S0140-6736(03)12675-X  0.01
2002 Watts J. Japan opens dating agency to improve birth rate. Lancet (London, England). 360: 1755. PMID 12480435  0.01
2002 Watts J. Bali bombing offers lessons for disaster relief Lancet. 360: 1401. PMID 12423998  0.01
2002 Watts J. In a climate of overwork, Japan tries to chill out Lancet. 360: 932. PMID 12354484  0.01
2002 Watts J. Balancing the "axis of evil" in northeast Asia Lancet. 360: 735. PMID 12296305 DOI: 10.1016/S0140-6736(02)09940-3  0.01
2002 Watts J. Court forces Japan to admit to dark past of bioweapons programme. Lancet (London, England). 360: 857. PMID 12243926 DOI: 10.1016/S0140-6736(02)11015-4  0.01
2002 Watts J. Victims of Japan's notorious Unit 731 sue. Lancet (London, England). 360: 628. PMID 12241948  0.01
2002 Watts J. Japan's largest mining companies back down in black lung disease case Lancet. 360: 471. PMID 12241733  0.01
2002 Watts J. Japan's fatal obsession with bodyweight Lancet. 360: 318. PMID 12147387  0.01
2002 Watts J. Japan tries again to contain health costs Lancet. 359: 2260. PMID 12103303  0.01
2002 Watts J. North Korea's healthy facade hides dying nation. Lancet (London, England). 359: 1840. PMID 12044391  0.01
2002 Watts J. Shortfall in food aid for North Korea. Lancet (London, England). 359: 1679. PMID 12020542 DOI: 10.1016/S0140-6736(02)08610-5  0.01
2002 Watts J. Public health experts concerned about "hikikomori". Lancet (London, England). 359: 1131. PMID 11943272  0.01
2002 Watts J. Domestic dispute mars Japan's Afghanistan summit. Lancet (London, England). 359: 413. PMID 11844525  0.01
1999 Watts J. Patients not to be tied up in Japanese sanatoriums The Lancet. 354: 316. PMID 11660634  0.01
1999 Watts J. Experiment sparks cloning debate in Japan The Lancet. 354: 1801. PMID 11657648  0.01
1999 Watts J. Japan set to make first legal prohibition on life-sciences research. Lancet (London, England). 354: 1885. PMID 11657575  0.01
1999 Watts J. Japanese medical records to stay under wraps. Lancet (London, England). 354: 54. PMID 11657546 DOI: 10.1016/S0140-6736(05)75324-1  0.01
1999 Watts J. Brain-death guidelines revised in Japan The Lancet. 354: 1011. PMID 11657502  0.01
1999 Watts J. Japan does its first official heart and liver transplantations. Lancet (London, England). 353: 821. PMID 11657078 DOI: 10.1016/S0140-6736(05)76493-X  0.01
1998 Watts J. Japan dashes Seed's plans for clone clinic. Lancet (London, England). 352: 1917. PMID 11657092 DOI: 10.1016/S0140-6736(05)60417-5  0.01
1998 Watts J. Concept of brain death to be accepted in South Korea. Lancet (London, England). 352: 1996. PMID 11656957 DOI: 10.1016/S0140-6736(05)61349-9  0.01
1998 Watts J. Japan proposes ban on human cloning. Lancet (London, England). 352: 465. PMID 11656950 DOI: 10.1016/S0140-6736(05)79210-2  0.01
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