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Scott Younger - Publications

Affiliations: 
2007-2012 Broad Institute, Cambridge, MA, United States 
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13/33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Malone CF, Dharia NV, Kugener G, Paolella B, Rothberg M, Abdusamad M, Gonzalez A, Dumont N, Younger S, Root D, Vazquez F, Stegmaier K. Abstract 2878: CRISPR-Cas9 screens identify the nuclear export factor NXT1 as a novel therapeutic target inMYCN-amplified neuroblastoma Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2878  0.331
2015 Shechner DM, Hacisuleyman E, Younger ST, Rinn JL. Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display. Nature Methods. 12: 664-70. PMID 26030444 DOI: 10.1038/nmeth.3433  0.579
2015 Younger ST, Kenzelmann-Broz D, Jung H, Attardi LD, Rinn JL. Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage. Nucleic Acids Research. 43: 4447-62. PMID 25883152 DOI: 10.1093/nar/gkv284  0.31
2015 Younger ST, Corey DR. Identification and validation of miRNA target sites within nontraditional miRNA targets. Methods in Molecular Biology (Clifton, N.J.). 1206: 53-67. PMID 25240886 DOI: 10.1007/978-1-4939-1369-5_5  0.63
2014 Younger ST, Rinn JL. 'Lnc'-ing enhancers to MYC regulation. Cell Research. 24: 643-4. PMID 24777251 DOI: 10.1038/cr.2014.54  0.442
2011 Younger ST, Corey DR. Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini. Molecular Biosystems. 7: 2383-8. PMID 21589992 DOI: 10.1039/C1Mb05090G  0.785
2011 Younger ST, Corey DR. Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters. Nucleic Acids Research. 39: 5682-91. PMID 21427083 DOI: 10.1093/Nar/Gkr155  0.717
2010 Chu Y, Yue X, Younger ST, Janowski BA, Corey DR. Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter. Nucleic Acids Research. 38: 7736-48. PMID 20675357 DOI: 10.1093/Nar/Gkq648  0.759
2010 Yue X, Schwartz JC, Chu Y, Younger ST, Gagnon KT, Elbashir S, Janowski BA, Corey DR. Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini. Nature Chemical Biology. 6: 621-9. PMID 20581822 DOI: 10.1038/Nchembio.400  0.652
2009 Younger ST, Pertsemlidis A, Corey DR. Predicting potential miRNA target sites within gene promoters. Bioorganic & Medicinal Chemistry Letters. 19: 3791-4. PMID 19423343 DOI: 10.1016/J.Bmcl.2009.04.032  0.729
2009 Younger ST, Corey DR. The puzzle of RNAs that target gene promoters. Chembiochem : a European Journal of Chemical Biology. 10: 1135-9. PMID 19301312 DOI: 10.1002/Cbic.200900015  0.716
2008 Schwartz JC, Younger ST, Nguyen NB, Hardy DB, Monia BP, Corey DR, Janowski BA. Antisense transcripts are targets for activating small RNAs. Nature Structural & Molecular Biology. 15: 842-8. PMID 18604220 DOI: 10.1038/Nsmb.1444  0.749
2007 Janowski BA, Younger ST, Hardy DB, Ram R, Huffman KE, Corey DR. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nature Chemical Biology. 3: 166-73. PMID 17259978 DOI: 10.1038/Nchembio860  0.747
Low-probability matches (unlikely to be authored by this person)
2017 Younger ST, Rinn JL. p53 regulates enhancer accessibility and activity in response to DNA damage. Nucleic Acids Research. 45: 9889-9900. PMID 28973438 DOI: 10.1093/nar/gkx577  0.275
2018 Piccioni F, Younger ST, Root DE. Pooled Lentiviral-Delivery Genetic Screens. Current Protocols in Molecular Biology. 121: 32.1.1-32.1.21. PMID 29337374 DOI: 10.1002/cpmb.52  0.269
2020 Borys SM, Younger ST. Identification of functional regulatory elements in the human genome using pooled CRISPR screens. Bmc Genomics. 21: 107. PMID 32005150 DOI: 10.1186/s12864-020-6497-0  0.251
2023 Cheung WA, Johnson AF, Rowell WJ, Farrow E, Hall R, Cohen ASA, Means JC, Zion TN, Portik DM, Saunders CT, Koseva B, Bi C, Truong TK, Schwendinger-Schreck C, Yoo B, ... ... Younger ST, et al. Direct haplotype-resolved 5-base HiFi sequencing for genome-wide profiling of hypermethylation outliers in a rare disease cohort. Nature Communications. 14: 3090. PMID 37248219 DOI: 10.1038/s41467-023-38782-1  0.248
2021 Xia S, Yu W, Menden H, Younger ST, Sampath V. Autoregulates Its Expression in the Pulmonary Endothelium After Endotoxin Stimulation in a Histone Acetylation-Dependent Manner. Frontiers in Cell and Developmental Biology. 9: 657662. PMID 34017833 DOI: 10.3389/fcell.2021.657662  0.234
2021 Dai C, Rennhack JP, Arnoff TE, Thaker M, Younger ST, Doench JG, Huang AY, Yang A, Aguirre AJ, Wang B, Mun E, O'Connell JT, Huang Y, Labella K, Talamas JA, et al. SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Cell Reports. 36: 109443. PMID 34320363 DOI: 10.1016/j.celrep.2021.109443  0.227
2021 Malone CF, Dharia NV, Kugener G, Forman AB, Rothberg MV, Abdusamad M, Gonzalez A, Kuljanin M, Robichaud AL, Saur Conway A, Dempster JM, Paolella BR, Dumont N, Hovestadt V, Mancias JD, ... Younger ST, et al. Selective modulation of a pan-essential protein as a therapeutic strategy in cancer. Cancer Discovery. PMID 33883167 DOI: 10.1158/2159-8290.CD-20-1213  0.226
2021 Lin S, Larrue C, Scheidegger NK, Seong BKA, Dharia NV, Kuljanin M, Wechsler CS, Kugener G, Robichaud AL, Saur Conway A, Mashaka T, Mouche S, Adane B, Ryan JA, Mancias JD, ... Younger ST, et al. An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML. Cancer Discovery. PMID 34531254 DOI: 10.1158/2159-8290.CD-20-1851  0.191
2018 Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, et al. Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival. Cancer Discovery. PMID 30373918 DOI: 10.1158/2159-8290.Cd-18-0389  0.185
2019 Dempster JM, Pacini C, Pantel S, Behan FM, Green T, Krill-Burger J, Beaver CM, Younger ST, Zhivich V, Najgebauer H, Allen F, Gonçalves E, Shepherd R, Doench JG, Yusa K, et al. Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nature Communications. 10: 5817. PMID 31862961 DOI: 10.1038/S41467-019-13805-Y  0.185
2021 Marinaccio C, Suraneni P, Celik H, Volk A, Wen QJ, Ling T, Bulic M, Lasho T, Koche RP, Famulare CA, Farnoud N, Stein B, Schieber M, Gurbuxani S, Root DE, ... Younger ST, et al. LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms. Cancer Discovery. PMID 33579786 DOI: 10.1158/2159-8290.CD-20-1353  0.137
2022 McQuerry JA, Mclaird M, Hartin SN, Means JC, Johnston J, Pastinen T, Younger ST. Massively parallel identification of functionally consequential noncoding genetic variants in undiagnosed rare disease patients. Scientific Reports. 12: 7576. PMID 35534523 DOI: 10.1038/s41598-022-11589-8  0.13
2023 Farrow E, Jay A, Means J, Younger S, Biswell R, Koseva B, Thiffault I, Pastinen T, Pappas K, Toriello H. Case of CLPB deficiency solved by HiFi long read genome sequencing and RNAseq. American Journal of Medical Genetics. Part A. PMID 37548286 DOI: 10.1002/ajmg.a.63365  0.111
2019 Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metabolism. PMID 30799286 DOI: 10.1016/J.Cmet.2019.01.020  0.096
2023 Arce FT, Younger S, Gaber AA, Mascarenhas JB, Rodriguez M, Dudek SM, Garcia JGN. Lamellipodia Dynamics and Microrheology in Endothelial Cell Paracellular Gap Closure. Biophysical Journal. PMID 37978804 DOI: 10.1016/j.bpj.2023.11.016  0.083
2015 Younger ST, Rinn JL. Silent pericentromeric repeats speak out. Proceedings of the National Academy of Sciences of the United States of America. PMID 26582791 DOI: 10.1073/pnas.1520341112  0.074
2020 Hartin SN, Means JC, Alaimo JT, Younger ST. Expediting rare disease diagnosis: a call to bridge the gap between clinical and functional genomics. Molecular Medicine (Cambridge, Mass.). 26: 117. PMID 33238891 DOI: 10.1186/s10020-020-00244-5  0.072
2022 Cohen ASA, Farrow EG, Abdelmoity AT, Alaimo JT, Amudhavalli SM, Anderson JT, Bansal L, Bartik L, Baybayan P, Belden B, Berrios CD, Biswell RL, Buczkowicz P, Buske O, Chakraborty S, ... ... Younger ST, et al. Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35305867 DOI: 10.1016/j.gim.2022.02.007  0.064
2020 Younger S, Jang H, Davies HA, Niemiec MJ, Garcia JGN, Nussinov R, Migrino RQ, Madine J, Arce FT. Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction. Biophysical Journal. PMID 32402244 DOI: 10.1016/J.Bpj.2020.04.026  0.052
2017 Najm FJ, Strand C, Donovan KF, Hegde M, Sanson KR, Vaimberg EW, Sullender ME, Hartenian E, Kalani Z, Fusi N, Listgarten J, Younger ST, Bernstein BE, Root DE, Doench JG. Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens. Nature Biotechnology. PMID 29251726 DOI: 10.1038/Nbt.4048  0.04
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