Year |
Citation |
Score |
2016 |
Lee SH, Le Pichon CE, Adolfsson O, Gafner V, Pihlgren M, Lin H, Solanoy H, Brendza R, Ngu H, Foreman O, Chan R, Ernst JA, DiCara D, Hotzel I, Srinivasan K, ... ... Bumbaca D, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Reports. PMID 27475227 DOI: 10.1016/J.Celrep.2016.06.099 |
0.389 |
|
2016 |
Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, et al. Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain. Cpt: Pharmacometrics & Systems Pharmacology. 5: 283-291. PMID 27299941 DOI: 10.1002/psp4.12081 |
0.423 |
|
2016 |
Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S. Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. Mabs. 1-11. PMID 26918260 DOI: 10.1080/19420862.2015.1136043 |
0.408 |
|
2015 |
Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, et al. Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies. Neuron. PMID 26687840 DOI: 10.1016/J.Neuron.2015.11.024 |
0.43 |
|
2015 |
Kinnunen HM, Sharma V, Contreras-Rojas LR, Yu Y, Alleman C, Sreedhara A, Fischer S, Khawli L, Yohe ST, Bumbaca D, Patapoff TW, Daugherty AL, Mrsny RJ. A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components. Journal of Controlled Release : Official Journal of the Controlled Release Society. 214: 94-102. PMID 26210441 DOI: 10.1016/J.Jconrel.2015.07.016 |
0.344 |
|
2015 |
Shen BQ, Bumbaca D, Yue Q, Saad O, Tibbitts J, Khojasteh SC, Girish S. Non-clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats. Drug Metabolism Letters. PMID 26031461 DOI: 10.2174/1872312809666150602151922 |
0.394 |
|
2015 |
Uppal H, Doudement E, Mahapatra K, Darbonne WC, Bumbaca D, Shen BQ, Du X, Saad O, Bowles K, Olsen S, Lewis Phillips GD, Hartley D, Sliwkowski MX, Girish S, Dambach D, et al. Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1). Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 123-33. PMID 25370470 DOI: 10.1158/1078-0432.Ccr-14-2093 |
0.34 |
|
2014 |
Kamath AV, Yip V, Gupta P, Boswell CA, Bumbaca D, Haughney P, Castro J, Tsai SP, Pacheco G, Ross S, Yan M, Damico-Beyer LA, Khawli L, Shen BQ. Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice. Mabs. 6: 1631-7. PMID 25484068 DOI: 10.4161/Mabs.36107 |
0.492 |
|
2014 |
Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Science Translational Medicine. 6: 261ra154. PMID 25378646 DOI: 10.1126/Scitranslmed.3009835 |
0.463 |
|
2014 |
Boswell CA, Mundo EE, Ulufatu S, Bumbaca D, Cahaya HS, Majidy N, Van Hoy M, Schweiger MG, Fielder PJ, Prabhu S, Khawli LA. Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues. Molecular Pharmaceutics. 11: 1591-8. PMID 24702191 DOI: 10.1021/Mp400748T |
0.389 |
|
2014 |
Yip V, Palma E, Tesar DB, Mundo EE, Bumbaca D, Torres EK, Reyes NA, Shen BQ, Fielder PJ, Prabhu S, Khawli LA, Boswell CA. Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor. Mabs. 6: 689-96. PMID 24572100 DOI: 10.4161/Mabs.28254 |
0.501 |
|
2014 |
Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. The Journal of Experimental Medicine. 211: 233-44. PMID 24470444 DOI: 10.1084/Jem.20131660 |
0.444 |
|
2013 |
Boswell CA, Marik J, Elowson MJ, Reyes NA, Ulufatu S, Bumbaca D, Yip V, Mundo EE, Majidy N, Van Hoy M, Goriparthi SN, Trias A, Gill HS, Williams SP, Junutula JR, et al. Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies. Journal of Medicinal Chemistry. 56: 9418-26. PMID 24131491 DOI: 10.1021/Jm401365H |
0.385 |
|
2013 |
Boswell CA, Mundo EE, Johnstone B, Ulufatu S, Schweiger MG, Bumbaca D, Fielder PJ, Prabhu S, Khawli LA. Vascular physiology and protein disposition in a preclinical model of neurodegeneration. Molecular Pharmaceutics. 10: 1514-21. PMID 23383983 DOI: 10.1021/Mp3004786 |
0.392 |
|
2012 |
Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF. A strategy for risk mitigation of antibodies with fast clearance. Mabs. 4: 753-60. PMID 23778268 DOI: 10.4161/Mabs.22189 |
0.493 |
|
2012 |
Boswell CA, Bumbaca D, Fielder PJ, Khawli LA. Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations. The Aaps Journal. 14: 612-8. PMID 22648903 DOI: 10.1208/S12248-012-9374-1 |
0.49 |
|
2012 |
Bumbaca D, Boswell CA, Fielder PJ, Khawli LA. Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics. The Aaps Journal. 14: 554-8. PMID 22610647 DOI: 10.1208/S12248-012-9369-Y |
0.493 |
|
2012 |
Shen BQ, Bumbaca D, Saad O, Yue Q, Pastuskovas CV, Khojasteh SC, Tibbitts J, Kaur S, Wang B, Chu YW, LoRusso PM, Girish S. Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism. Current Drug Metabolism. 13: 901-10. PMID 22475269 DOI: 10.2174/138920012802138598 |
0.345 |
|
2012 |
Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, et al. Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration. Mabs. 4: 243-55. PMID 22453096 DOI: 10.4161/Mabs.4.2.19387 |
0.437 |
|
2012 |
Bumbaca D, Tong RK, Koch AW, Xiang H, DeForge LE, Shen BQ, Lu Y. A case study on Sema3E-Fc aggregation and assay-dependent differences in quantitation. Bioanalysis. 4: 703-11. PMID 22452261 DOI: 10.4155/Bio.12.30 |
0.354 |
|
2012 |
Pastuskovas CV, Mundo EE, Williams SP, Nayak TK, Ho J, Ulufatu S, Clark S, Ross S, Cheng E, Parsons-Reponte K, Cain G, Van Hoy M, Majidy N, Bheddah S, dela Cruz Chuh J, ... ... Bumbaca D, et al. Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Molecular Cancer Therapeutics. 11: 752-62. PMID 22222630 DOI: 10.1158/1535-7163.Mct-11-0742-T |
0.445 |
|
2012 |
Bumbaca D, Xiang H, Boswell CA, Port RE, Stainton SL, Mundo EE, Ulufatu S, Bagri A, Theil FP, Fielder PJ, Khawli LA, Shen BQ. Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice. British Journal of Pharmacology. 166: 368-77. PMID 22074316 DOI: 10.1111/J.1476-5381.2011.01777.X |
0.463 |
|
2011 |
Boswell CA, Mundo EE, Zhang C, Bumbaca D, Valle NR, Kozak KR, Fourie A, Chuh J, Koppada N, Saad O, Gill H, Shen BQ, Rubinfeld B, Tibbitts J, Kaur S, et al. Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats. Bioconjugate Chemistry. 22: 1994-2004. PMID 21913715 DOI: 10.1021/Bc200212A |
0.521 |
|
2011 |
Bumbaca D, Wong A, Drake E, Reyes AE, Lin BC, Stephan JP, Desnoyers L, Shen BQ, Dennis MS. Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4. Mabs. 3: 376-86. PMID 21540647 DOI: 10.4161/Mabs.3.4.15786 |
0.475 |
|
2011 |
Boswell CA, Ferl GZ, Mundo EE, Bumbaca D, Schweiger MG, Theil FP, Fielder PJ, Khawli LA. Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow. Plos One. 6: e17874. PMID 21436893 DOI: 10.1371/Journal.Pone.0017874 |
0.429 |
|
2011 |
Bumbaca D, Boswell CA, Mundo EE, Xin Y, Xiang H, Port RE, Schweiger MG, Stainton SL, Bagri A, Theil FP, Fielder PJ, Khawli LA, Shen BQ. Abstract 4588: Tumor distribution of anti-neuropilin-1 is affected by antibody dose level in a tumor xenograft mouse model Cancer Research. 71: 4588-4588. DOI: 10.1158/1538-7445.Am2011-4588 |
0.434 |
|
2011 |
Wong S, Bumbaca D, Yue Q, Halladay J, Kenny JR, Salphati L, Saad O, Tibbitts J, Khojasteh C, Girish S, Shen B. Abstract A136: Nonclinical disposition, metabolism, and in vitro drug-drug interaction assessment of DM1, a component of trastuzumab emtansine (T-DM1). Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A136 |
0.389 |
|
2011 |
Mahapatra K, Darbonne W, Bumbaca D, Shen B, Du X, Tibbitts J, Olsen S, Sliwkowski M, Girish S, Hartley D, Dambach D, Ramakrishnan V, Uppal H. Abstract A135: T-DM1-induced thrombocytopenia results from impaired platelet production in a HER2-independent manner. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A135 |
0.36 |
|
2010 |
Bumbaca D, Boswell CA, Xiang H, Port R, Schweiger M, Stainton S, Bagri A, Theil F, Fielder PJ, Khawli LA, Shen B. Abstract 696: Anti-NRP1 tumor uptake is impacted by normal tissue sinks in a tumor bearing mouse model Cancer Research. 70: 696-696. DOI: 10.1158/1538-7445.Am10-696 |
0.429 |
|
Low-probability matches (unlikely to be authored by this person) |
2014 |
Bumbaca D, Bumbaca D, Wildsmith K, Fuji R, Scearce-Levie K, Maloney J, Meilandt W, Solanoy H, Lu Y, Peng K, Wilson B, Chan P, Kosky A, Goo M, Daugherty A, et al. P1-359: WIDESPREAD BRAIN DISTRIBUTION AND ROBUST BACE1 INHIBITION FOLLOWING INTRACEREBROVENTRICULAR INFUSION OF ANTI-BACE1 IN NON-HUMAN PRIMATES Alzheimer's & Dementia. 10: P445-P445. DOI: 10.1016/J.Jalz.2014.05.601 |
0.257 |
|
2004 |
Bumbaca D, Littlejohn JE, Nayakanti H, Rigden DJ, Galperin MY, Jedrzejas MJ. Sequence analysis and characterization of a novel fibronectin-binding repeat domain from the surface of Streptococcus pneumoniae. Omics : a Journal of Integrative Biology. 8: 341-56. PMID 15703481 DOI: 10.1089/omi.2004.8.341 |
0.128 |
|
2007 |
Bumbaca D, Littlejohn JE, Nayakanti H, Lucas AH, Rigden DJ, Galperin MY, Jedrzejas MJ. Genome-based identification and characterization of a putative mucin-binding protein from the surface of Streptococcus pneumoniae. Proteins. 66: 547-58. PMID 17115425 DOI: 10.1002/prot.21205 |
0.093 |
|
2007 |
Bumbaca D, Kosman J, Setlow P, Henderson RK, Jedrzejas MJ. Crystallization and preliminary X-ray analysis of the complex between a Bacillus subtilis α/β-type small acid-soluble spore protein and DNA Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63: 503-506. PMID 17554173 DOI: 10.1107/S1744309107022750 |
0.053 |
|
2008 |
Lee KS, Bumbaca D, Kosman J, Setlow P, Jedrzejas MJ. Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species. Proceedings of the National Academy of Sciences of the United States of America. 105: 2806-11. PMID 18287075 DOI: 10.1073/Pnas.0708244105 |
0.044 |
|
Hide low-probability matches. |